Regis J. O'keefe†
#148,448
Most Influential Person Now
Regis J. O'keefe†'s AcademicInfluence.com Rankings
Regis J. O'keefe†philosophy Degrees
Philosophy
#8092
World Rank
#11410
Historical Rank
Logic
#5123
World Rank
#6491
Historical Rank
Download Badge
Philosophy
Why Is Regis J. O'keefe† Influential?
(Suggest an Edit or Addition)Regis J. O'keefe†'s Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Atypical Subtrochanteric and Diaphyseal Femoral Fractures: Second Report of a Task Force of the American Society for Bone and Mineral Research (2011) (1417)
- Atypical subtrochanteric and diaphyseal femoral fractures: Report of a task force of the american society for bone and mineral Research (2010) (1063)
- Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair. (2002) (697)
- Activation of β‐Catenin Signaling in Articular Chondrocytes Leads to Osteoarthritis‐Like Phenotype in Adult β‐Catenin Conditional Activation Mice (2009) (415)
- Runx2-mediated regulation of the zinc finger Osterix/Sp7 gene. (2006) (333)
- Periosteal Progenitor Cell Fate in Segmental Cortical Bone Graft Transplantations: Implications for Functional Tissue Engineering (2005) (305)
- The biology of the growth plate. (2003) (271)
- Remodeling of cortical bone allografts mediated by adherent rAAV-RANKL and VEGF gene therapy (2005) (271)
- Inhibition of beta-catenin signaling in articular chondrocytes results in articular cartilage destruction. (2008) (246)
- Regulation of chondrogenesis and chondrocyte differentiation by stress. (2008) (243)
- Articular Cartilage Biology (2003) (241)
- RANK Signaling Is Not Required for TNFα‐Mediated Increase in CD11bhi Osteoclast Precursors but Is Essential for Mature Osteoclast Formation in TNFα‐Mediated Inflammatory Arthritis (2003) (231)
- Wnt induction of chondrocyte hypertrophy through the Runx2 transcription factor (2006) (223)
- Bone tissue engineering and regeneration: from discovery to the clinic--an overview. (2011) (223)
- BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development (2011) (222)
- Atypical subtrochanteric and diaphyseal femoral fractures: Report of a task force of the American Society for Bone and Mineral Research (2011) (215)
- A Perspective: Engineering Periosteum for Structural Bone Graft Healing (2008) (206)
- BMP‐6 Is an Autocrine Stimulator of Chondrocyte Differentiation (1999) (195)
- Tumor necrosis factor‐α/nuclear transcription factor‐κB signaling in periprosthetic osteolysis (2000) (194)
- TNFα and pathologic bone resorption (2005) (184)
- Systemic tumor necrosis factor α mediates an increase in peripheral CD11bhigh osteoclast precursors in tumor necrosis factor α–transgenic mice (2004) (168)
- Efficacy of Etanercept for Wear Debris‐Induced Osteolysis (2001) (166)
- In Vivo RANK Signaling Blockade Using the Receptor Activator of NF‐κB:Fc Effectively Prevents and Ameliorates Wear Debris‐Induced Osteolysis via Osteoclast Depletion Without Inhibiting Osteogenesis (2002) (165)
- Tumor metastasis and the reciprocal regulation of prometastatic and antimetastatic factors by nuclear factor kappaB. (2000) (161)
- Deletion of the transforming growth factor β receptor type II gene in articular chondrocytes leads to a progressive osteoarthritis-like phenotype in mice. (2013) (159)
- Reduced COX-2 Expression in Aged Mice Is Associated With Impaired Fracture Healing (2008) (157)
- Physiology and pathophysiology of the growth plate. (2003) (156)
- Recombinant Adeno-Associated Virus-Mediated Osteoprotegerin Gene Therapy Inhibits Wear Debris-Induced Osteolysis (2002) (154)
- The molecular pathophysiology of subacromial bursitis in rotator cuff disease. (2005) (154)
- RBPjκ-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development (2010) (153)
- Smad6 Interacts with Runx2 and Mediates Smad Ubiquitin Regulatory Factor 1-induced Runx2 Degradation* (2006) (150)
- Proinflammatory cytokines and metalloproteases are expressed in the subacromial bursa in patients with rotator cuff disease. (2005) (149)
- Inflammation and epigenetic regulation in osteoarthritis (2017) (147)
- The potential role of transforming growth factor beta in fracture healing. (1998) (143)
- Smad2 and 3 mediate transforming growth factor-beta1-induced inhibition of chondrocyte maturation. (2000) (139)
- Smad3‐Deficient Chondrocytes Have Enhanced BMP Signaling and Accelerated Differentiation (2005) (138)
- Inhibition of β-catenin signaling causes defects in postnatal cartilage development (2008) (138)
- Generation of a transgenic mouse model with chondrocyte‐specific and tamoxifen‐inducible expression of Cre recombinase (2007) (138)
- Quantitative mouse model of implant‐associated osteomyelitis and the kinetics of microbial growth, osteolysis, and humoral immunity (2008) (136)
- COX‐1 and COX‐2 expression in osteoid osteomas (2002) (135)
- Teriparatide as a Chondroregenerative Therapy for Injury-Induced Osteoarthritis (2011) (135)
- Increased Levels of Tumor Necrosis Factor-&agr; and Interleukin-6 Protein and Messenger RNA in Human Peripheral Blood Monocytes due to Titanium Particles* (1996) (128)
- Effects of transforming growth factor-β on matrix synthesis by chick growth plate chondrocytes (1988) (128)
- Transforming growth factor beta: an autocrine regulator of chondrocytes. (1989) (125)
- Runx1/AML1/Cbfa2 Mediates Onset of Mesenchymal Cell Differentiation Toward Chondrogenesis (2005) (124)
- ALK2 Functions as a BMP Type I Receptor and Induces Indian Hedgehog in Chondrocytes During Skeletal Development (2003) (121)
- Transcriptional regulation of chondrocyte maturation: potential involvement of transcription factors in OA pathogenesis. (2005) (120)
- Cyclin D1-Cdk4 Induce Runx2 Ubiquitination and Degradation* (2006) (118)
- TNF-alpha and pathologic bone resorption. (2005) (118)
- PTHrP Modulates Chondrocyte Differentiation through AP-1 and CREB Signaling* (2001) (118)
- Induction of an osteoarthritis-like phenotype and degradation of phosphorylated Smad3 by Smurf2 in transgenic mice. (2008) (117)
- Murine and Chicken Chondrocytes Regulate Osteoclastogenesis by Producing RANKL in Response to BMP2 (2007) (116)
- Cartilage‐specific β‐catenin signaling regulates chondrocyte maturation, generation of ossification centers, and perichondrial bone formation during skeletal development (2012) (116)
- BMP signaling stimulates chondrocyte maturation and the expression of Indian hedgehog (2001) (116)
- Quantitative small‐animal surrogate to evaluate drug efficacy in preventing wear debris‐induced osteolysis (2000) (116)
- Structural bone allograft combined with genetically engineered mesenchymal stem cells as a novel platform for bone tissue engineering. (2006) (116)
- Lead Exposure Inhibits Fracture Healing and Is Associated with Increased Chondrogenesis, Delay in Cartilage Mineralization, and a Decrease in Osteoprogenitor Frequency (2005) (115)
- Primary murine limb bud mesenchymal cells in long-term culture complete chondrocyte differentiation: TGF-beta delays hypertrophy and PGE2 inhibits terminal differentiation. (2004) (114)
- Efficacy of ex vivo OPG gene therapy in preventing wear debris induced osteolysis (2002) (112)
- Evidence for a Direct Role of Cyclo‐Oxygenase 2 in Implant Wear Debris‐Induced Osteolysis (2001) (110)
- Overlapping expression of Runx1(Cbfa2) and Runx2(Cbfa1) transcription factors supports cooperative induction of skeletal development (2005) (109)
- TGF-beta signaling in chondrocytes. (2005) (108)
- Inhibition of the Wnt-β-catenin and Notch signaling pathways sensitizes osteosarcoma cells to chemotherapy. (2013) (108)
- Osterix/Sp7 regulates mesenchymal stem cell mediated endochondral ossification (2008) (108)
- Systemic tumor necrosis factor alpha mediates an increase in peripheral CD11bhigh osteoclast precursors in tumor necrosis factor alpha-transgenic mice. (2004) (106)
- Forum on bone and skeletal muscle interactions: Summary of the proceedings of an ASBMR workshop (2013) (106)
- Biological effects of rAAV-caAlk2 coating on structural allograft healing. (2005) (104)
- The Convergence of Fracture Repair and Stem Cells: Interplay of Genes, Aging, Environmental Factors and Disease (2014) (103)
- LDHA-mediated ROS generation in chondrocytes is a potential therapeutic target for osteoarthritis (2020) (103)
- Effect of Anti‐Tumor Necrosis Factor-&agr; Gene Therapy on Wear Debris‐Induced Osteolysis (2001) (98)
- Axin2 controls bone remodeling through the β-catenin–BMP signaling pathway in adult mice (2009) (98)
- A Role for the BMP Antagonist Chordin in Endochondral Ossification (2002) (97)
- Fibroblasts Express RANKL and Support Osteoclastogenesis in a COX‐2‐Dependent Manner After Stimulation With Titanium Particles (2005) (97)
- Rescue of impaired fracture healing in COX-2-/- mice via activation of prostaglandin E2 receptor subtype 4. (2009) (97)
- Volumetric computerized tomography as a measurement of periprosthetic acetabular osteolysis and its correlation with wear (2001) (96)
- Runx2/Cbfa1 stimulation by retinoic acid is potentiated by BMP2 signaling through interaction with Smad1 on the collagen X promoter in chondrocytes (2003) (96)
- Granular Histiocytosis of Pelvic Lymph Nodes following Total Hip Arthroplasty. The Presence of Wear Debris, Cytokine Production, and Immunologically Activated Macrophages* (1996) (95)
- Conditional activation of β-catenin signaling in mice leads to severe defects in intervertebral disc tissue. (2012) (94)
- Parathyroid hormone-related peptide (PTHrP) inhibits Runx2 expression through the PKA signaling pathway. (2004) (94)
- Cartilage-specific RBPjκ-dependent and -independent Notch signals regulate cartilage and bone development (2012) (92)
- Impact of Smad3 loss of function on scarring and adhesion formation during tendon healing (2011) (91)
- Remodeling of murine intrasynovial tendon adhesions following injury: MMP and neotendon gene expression (2009) (91)
- A Phage Display Technique Identifies a Novel Regulator of Cell Differentiation* (2003) (88)
- Orthopaedic basic science : foundations of clinical practice (2007) (88)
- Teriparatide (1‐34 human PTH) regulation of osterix during fracture repair (2008) (87)
- Use of volumetric computerized tomography as a primary outcome measure to evaluate drug efficacy in the prevention of peri‐prosthetic osteolysis: A 1‐year clinical pilot of etanercept vs. placebo (2003) (87)
- In vivo prostaglandin E2 treatment alters the bone marrow microenvironment and preferentially expands short-term hematopoietic stem cells. (2009) (86)
- Influence of prostaglandins on DNA and matrix synthesis in growth plate chondrocytes (1992) (84)
- PGE2 inhibits chondrocyte differentiation through PKA and PKC signaling. (2004) (84)
- A novel murine segmental femoral graft model (2004) (83)
- Modulation of the Production of Cytokines in Titanium-Stimulated Human Peripheral Blood Monocytes by Pharmacological Agents. The Role of cAMP-Mediated Signaling Mechanisms*† (1997) (82)
- Role of surgical resection in pelvic Ewing's sarcoma. (1995) (82)
- Anti-TNF-α therapy as a clinical intervention for periprosthetic osteolysis (2000) (81)
- Viral interleukin-10 gene inhibition of inflammation, osteoclastogenesis, and bone resorption in response to titanium particles. (2002) (79)
- Effects of receptor activator of NFκB (RANK) signaling blockade on fracture healing (2003) (79)
- NFκB: A Pivotal Transcription Factor in Prostate Cancer Metastasis to Bone (2003) (79)
- Freeze-dried tendon allografts as tissue-engineering scaffolds for Gdf5 gene delivery. (2008) (79)
- TAK1 Regulates Cartilage and Joint Development via the MAPK and BMP Signaling Pathways (2010) (78)
- Delayed Fracture Healing and Increased Callus Adiposity in a C57BL/6J Murine Model of Obesity-Associated Type 2 Diabetes Mellitus (2014) (77)
- Cellular and Molecular Factors in Flexor Tendon Repair and Adhesions: A Histological and Gene Expression Analysis (2013) (76)
- The Surgical Treatment of Patients With Osteosarcoma Who Sustain a Pathologic Fracture (1996) (76)
- NOTCH signaling in skeletal progenitors is critical for fracture repair. (2016) (76)
- Gene Expression Analysis of the Pleiotropic Effects of TGF-β1 in an In Vitro Model of Flexor Tendon Healing (2012) (76)
- A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis (2015) (75)
- Runx2-mediated activation of the Bax gene increases osteosarcoma cell sensitivity to apoptosis (2008) (74)
- Thrombospondin-2 Influences the Proportion of Cartilage and Bone During Fracture Healing (2009) (74)
- Adhesions in a murine flexor tendon graft model: Autograft versus allograft reconstruction (2008) (73)
- Wnt‐mediated regulation of chondrocyte maturation: Modulation by TGF‐β (2005) (73)
- Erratum: Atypical subtrochanteric and diaphyseal femoral fractures: Report of a task force of the American Society for Bone and Mineral Research (Journal of Bone and Mineral Research (2010) 25 (2267-2294)) (2011) (72)
- Effects of transforming growth factor‐β1 and fibroblast growth factor on DNA synthesis in growth plate chondrocytes are enhanced by insulin‐like growth factor‐I (1994) (71)
- Aging periosteal progenitor cells have reduced regenerative responsiveness to bone injury and to the anabolic actions of PTH 1-34 treatment. (2014) (71)
- Transforming Growth Factor-β Stimulates Cyclin D1 Expression through Activation of β-Catenin Signaling in Chondrocytes* (2006) (70)
- Synergistic effect of transforming growth factor β and fibroblast growth factor on DNA synthesis in chick growth plate chondrocytes (1990) (69)
- Primary lymphoma of bone. Correlation of magnetic resonance imaging features with cytokine production by tumor cells (1995) (69)
- Smurf2 induces degradation of GSK-3beta and upregulates beta-catenin in chondrocytes: a potential mechanism for Smurf2-induced degeneration of articular cartilage. (2009) (68)
- COX-2 from the injury milieu is critical for the initiation of periosteal progenitor cell mediated bone healing. (2008) (67)
- Late recurrence of giant-cell tumor of bone. A report of four cases. (1994) (66)
- Smad7 mediates inhibition of Saos2 osteosarcoma cell differentiation by NFκB (2006) (65)
- Axin1 and Axin2 Are Regulated by TGF‐β and Mediate Cross‐talk between TGF‐β and Wnt Signaling Pathways (2007) (65)
- Bone Morphogenetic Protein 2 Activates Smad6 Gene Transcription through Bone-specific Transcription Factor Runx2* (2007) (65)
- Functional Outcome after Soft‐Tissue Reconstruction for Limb Salvage after Sarcoma Surgery (1998) (65)
- Shared phenotypic expression of osteoblasts and chondrocytes in fracture callus (1995) (65)
- Targeted Deletion of Minpp1 Provides New Insight into the Activity of Multiple Inositol Polyphosphate Phosphatase In Vivo (2000) (64)
- Periprosthetic osteolysis: an immunologist's update (2006) (64)
- Retinoic acid stimulates chondrocyte differentiation and enhances bone morphogenetic protein effects through induction of Smad1 and Smad5. (2003) (64)
- Multiple inositol polyphosphate phosphatase: evolution as a distinct group within the histidine phosphatase family and chromosomal localization of the human and mouse genes to chromosomes 10q23 and 19. (1999) (62)
- Exposure to receptor-activator of NFκB ligand renders pre-osteoclasts resistant to IFN-γ by inducing terminal differentiation (2002) (62)
- Pelvic reconstruction for severe periacetabular metastatic disease. (1999) (62)
- Micro-computed tomography prediction of biomechanical strength in murine structural bone grafts. (2007) (62)
- Oral Pentoxifylline Inhibits Release of Tumor Necrosis Factor-Alpha from Human Peripheral Blood Monocytes: A Potential Treatment for Aseptic Loosening of Total Joint Components (2001) (61)
- Effects of lead on growth plate chondrocyte phenotype. (1996) (60)
- PTHrP expression in chondrocytes, regulation by TGF-beta, and interactions between epiphyseal and growth plate chondrocytes. (2000) (60)
- PGE2 Signaling Through the EP4 Receptor on Fibroblasts Upregulates RANKL and Stimulates Osteolysis (2009) (60)
- Self-complementary AAV2.5-BMP2-coated femoral allografts mediated superior bone healing versus live autografts in mice with equivalent biomechanics to unfractured femur. (2011) (58)
- PGE2 and IL‐6 production by fibroblasts in response to titanium wear debris particles is mediated through a Cox‐2 dependent pathway (2004) (58)
- Transforming growth factor-beta and Wnt signals regulate chondrocyte differentiation through Twist1 in a stage-specific manner. (2007) (57)
- Teriparatide therapy enhances devitalized femoral allograft osseointegration and biomechanics in a murine model. (2011) (57)
- Runx3/AML2/Cbfa3 Regulates Early and Late Chondrocyte Differentiation (2007) (57)
- PTH‐enhanced structural allograft healing is associated with decreased angiopoietin‐2–mediated arteriogenesis, mast cell accumulation, and fibrosis (2013) (55)
- CREB Cooperates with BMP‐stimulated Smad signaling to enhance transcription of the Smad6 promoter (2004) (54)
- Differential regulation of type‐II and type‐X collagen synthesis by parathyroid hormone‐related protein in chick growth‐plate chondrocytes (1997) (54)
- Aberrant hypertrophy in Smad3-deficient murine chondrocytes is rescued by restoring transforming growth factor beta-activated kinase 1/activating transcription factor 2 signaling: a potential clinical implication for osteoarthritis. (2010) (54)
- Targeting Radioresistant Osteosarcoma Cells With Parthenolide (2012) (53)
- Osteoclasts constitutively express regulators of bone resorption: an immunohistochemical and in situ hybridization study. (1997) (53)
- 5‐azacytidine alters TGF‐β and BMP signaling and induces maturation in articular chondrocytes (2004) (52)
- β‐catenin, cartilage, and osteoarthritis (2010) (51)
- Calcific myonecrosis. A late sequela to compartment syndrome of the leg. (1995) (51)
- Differential effects of biologic versus bisphosphonate inhibition of wear debris‐induced osteolysis assessed by longitudinal micro‐CT (2008) (51)
- Evaluation of dense polylactic acid/beta-tricalcium phosphate scaffolds for bone tissue engineering. (2010) (51)
- Recent advances in gene delivery for structural bone allografts. (2007) (50)
- Establishment of an index with increased sensitivity for assessing murine arthritis (2011) (49)
- Smad6 is induced by BMP‐2 and modulates chondrocyte differentiation (2003) (49)
- Tamoxifen-inducible Cre-recombination in articular chondrocytes of adult Col2a1-CreER(T2) transgenic mice. (2008) (49)
- COX‐2 has a Critical Role During Incorporation of Structural Bone Allografts (2006) (48)
- Giant Cell Tumor of Bone in the Foot and Ankle (1995) (47)
- The Impact of Smad3 Loss of Function on TGF-&bgr; Signaling and Radiation-Induced Capsular Contracture (2011) (47)
- Isolation and culture of neonatal mouse calvarial osteoblasts. (2014) (47)
- TAK1 regulates SOX9 expression in chondrocytes and is essential for postnatal development of the growth plate and articular cartilages (2013) (47)
- RBP-Jκ-dependent Notch signaling is required for murine articular cartilage and joint maintenance. (2013) (45)
- Use of a Phage Display Technique to Identify Potential Osteoblast Binding Sites Within Osteoclast Lacunae (2002) (45)
- Endogenous tissue engineering: PTH therapy for skeletal repair (2012) (45)
- Cytokine and matrix metalloproteinase expression in pigmented villonodular synovitis may mediate bone and cartilage destruction. (1998) (45)
- Aryl hydrocarbon receptor‐mediated impairment of chondrogenesis and fracture healing by cigarette smoke and benzo(α)pyrene (2012) (45)
- Extraosseous primary and recurrent giant cell tumors: transforming growth factor-beta1 and -beta2 expression may explain metaplastic bone formation. (1996) (45)
- Runx2 plays a central role in Osteoarthritis development (2019) (44)
- Transforming growth factor-beta stimulates cyclin D1 expression through activation of beta-catenin signaling in chondrocytes. (2006) (44)
- RANK, RANKL and OPG in inflammatory arthritis and periprosthetic osteolysis. (2004) (44)
- Malignant reversion of a human osteosarcoma cell line, Saos-2, by inhibition of NFkappaB. (2002) (43)
- DNA methyltransferase 3b regulates articular cartilage homeostasis by altering metabolism. (2017) (43)
- Mitochondrial Dysfunction and Permeability Transition in Osteosarcoma Cells Showing the Warburg Effect* (2013) (43)
- The Role of Muscle in Bone Repair: The Cells, Signals, and Tissue Responses to Injury (2013) (43)
- The orally bioavailable met inhibitor PF‐2341066 inhibits osteosarcoma growth and osteolysis/matrix production in a xenograft model (2011) (42)
- NF-κB Regulates VCAM-1 Expression on Fibroblast-Like Synoviocytes1 (2000) (42)
- Axin2 regulates chondrocyte maturation and axial skeletal development (2009) (41)
- μCT‐Based Measurement of Cortical Bone Graft‐to‐Host Union (2009) (39)
- EP1−/− Mice Have Enhanced Osteoblast Differentiation and Accelerated Fracture Repair (2010) (39)
- Efficacy of colistin‐impregnated beads to prevent multidrug‐resistant A. baumannii implant‐associated osteomyelitis (2009) (39)
- Smad7 mediates inhibition of Saos2 osteosarcoma cell differentiation by NFkappaB. (2006) (39)
- Smad2 and 3 Mediate Transforming Growth Factor-β1-Induced Inhibition of Chondrocyte Maturation* *The work was supported by National Health Services Grant AR-38945 (to R.J.O.) and an Orthopaedic Research Education Foundation Award (to C.M.F.). (2000) (38)
- Distinct metabolic programs induced by TGF-β1 and BMP2 in human articular chondrocytes with osteoarthritis (2018) (38)
- ATF-2 cooperates with Smad3 to mediate TGF-β effects on chondrocyte maturation (2003) (37)
- Primary murine growth plate and articular chondrocyte isolation and cell culture. (2015) (37)
- Light-activated gene transduction enhances adeno-associated virus vector-mediated gene expression in human articular chondrocytes. (2002) (37)
- Mastocytosis presenting as a skeletal disorder. (1996) (37)
- Lead alters parathyroid hormone‐related peptide and transforming growth factor‐β1 effects and AP‐1 and NF‐κKB signaling in chondrocytes (2002) (36)
- Development of antisense oligonucleotide (ASO) technology against Tgf‐β signaling to prevent scarring during flexor tendon repair (2015) (36)
- Hyaluronic acid therapy. (2000) (36)
- Periosteal stem cells are essential for bone revitalization and repair. (2005) (36)
- Delayed short‐course treatment with teriparatide (PTH1–34) improves femoral allograft healing by enhancing intramembranous bone formation at the graft–host junction (2012) (36)
- Bone Marrow-Derived Matrix Metalloproteinase-9 Is Associated with Fibrous Adhesion Formation after Murine Flexor Tendon Injury (2012) (35)
- Autoimmunity and Bone (2006) (35)
- Assessment and management of the orthopedic and other complications of Proteus syndrome (2011) (35)
- Cloning of the chick BMP1/Tolloid cDNA and expression in skeletal tissues. (2000) (35)
- Transforming growth factor‐β1 induced alteration of skeletal morphogenesis in vivo (2004) (34)
- Notch signaling controls chondrocyte hypertrophy via indirect regulation of Sox9 (2015) (34)
- Bone morphogenetic protein‐7 in growth‐plate chondrocytes: Regulation by retinoic acid is dependent on the stage of chondrocyte maturation (1998) (34)
- Countercurrent centrifugal elutriation. High-resolution method for the separation of growth-plate chondrocytes. (1989) (34)
- Interleukin‐10 inhibits cytokine synthesis in monocytes stimulated by titanium particles: Evidence of an anti‐inflammatory regulatory pathway (1998) (34)
- Mycobacterium bovis osteomyelitis involving a hip arthroplasty after intravesicular bacille Calmette-Guérin for bladder cancer. (1998) (34)
- Ski inhibits TGF‐β/phospho‐Smad3 signaling and accelerates hypertrophic differentiation in chondrocytes (2012) (34)
- FoxO1 is a crucial mediator of TGF-β/TAK1 signaling and protects against osteoarthritis by maintaining articular cartilage homeostasis (2020) (33)
- BMP-2 induces ATF4 phosphorylation in chondrocytes through a COX-2/PGE2 dependent signaling pathway. (2014) (33)
- Fibrinolysis as a Target to Enhance Fracture Healing. (2015) (33)
- NOTCH‐Mediated Maintenance and Expansion of Human Bone Marrow Stromal/Stem Cells: A Technology Designed for Orthopedic Regenerative Medicine (2014) (32)
- Molecular mechanisms of bone metastasis and therapeutic implications. (2003) (32)
- Alteration of femoral bone morphology and density in COX-2-/- mice. (2006) (32)
- HiPER1, a phosphatase of the endoplasmic reticulum with a role in chondrocyte maturation. (1998) (32)
- PTHrP expression in chick sternal chondrocytes is regulated by TGF‐β through Smad‐mediated signaling (2001) (32)
- Analysis of type II and type X collagen synthesis in cultured growth plate chondrocytes by in situ hybridization: Rapid induction of type X collagen in culture (1994) (32)
- Immunohistochemical study of receptor activator of nuclear factor kappa‐B ligand (RANK‐L) in human osteolytic bone tumors (2002) (31)
- Overexpression of Smurf2 Stimulates Endochondral Ossification Through Upregulation of β‐Catenin (2007) (31)
- P‐glycoprotein expression in cartilaginous tumors (1997) (31)
- Effects of antiresorptive agents on osteomyelitis (2010) (30)
- Teriparatide therapy and beta-tricalcium phosphate enhance scaffold reconstruction of mouse femoral defects. (2011) (30)
- Nuclear factor-kappaB-dependent mechanisms in breast cancer cells regulate tumor burden and osteolysis in bone. (2005) (30)
- Reduction of particle-induced osteolysis by interleukin-6 involves anti-inflammatory effect and inhibition of early osteoclast precursor differentiation. (2009) (30)
- Differential regulation of EP receptor isoforms during chondrogenesis and chondrocyte maturation. (2005) (29)
- A Novel Animal Model for Studying Silicone Gel–Related Capsular Contracture (2010) (29)
- Clinical Outcome of 38 Patients With Juxtacortical Osteosarcoma (2000) (29)
- Molecular biology and therapeutics in musculoskeletal oncology. (2009) (28)
- Factors Associated With Early Improvement in Low Back Pain After Total Hip Arthroplasty: A Multi-Center Prospective Cohort Analyses. (2016) (28)
- Deletion of EP4 in S100a4-lineage cells reduces scar tissue formation during early but not later stages of tendon healing (2017) (27)
- Bone density changes after radiation for extremity sarcomas: exploring the etiology of pathologic fractures. (2011) (27)
- Effects of transforming growth factor-beta 1 and fibroblast growth factor on DNA synthesis in growth plate chondrocytes are enhanced by insulin-like growth factor-I. (1994) (27)
- Atypical femur fractures. (2014) (27)
- The histone deacetylase inhibitor vorinostat selectively sensitizes fibrosarcoma cells to chemotherapy (2011) (27)
- Increased radiation‐induced apoptosis of Saos2 cells via inhibition of NFκB: A role for c‐Jun N‐terminal kinase (2005) (26)
- Lead Induces Chondrogenesis and Alters Transforming Growth Factor-β and Bone Morphogenetic Protein Signaling in Mesenchymal Cell Populations (2007) (26)
- The Role of Autocrine Growth Factors in Radiation Damage to the Epiphyseal Growth Plate (2001) (26)
- The Mevalonate Synthesis Pathway as a Therapeutic Target in Cancer (2003) (26)
- Clinical presentation of alveolar soft-part sarcoma. (1994) (26)
- The role of p105 protein in NFκB activation in ANA‐1 murine macrophages following stimulation with titanium particles (2002) (26)
- CCN1 Regulates Chondrocyte Maturation and Cartilage Development (2016) (25)
- The Spatiotemporal Role of COX-2 in Osteogenic and Chondrogenic Differentiation of Periosteum-Derived Mesenchymal Progenitors in Fracture Repair (2014) (25)
- Prostaglandin E2 inhibits BMP signaling and delays chondrocyte maturation (2009) (25)
- Inhibition of beta‐catenin signaling by Pb leads to incomplete fracture healing (2014) (25)
- Synergism of Aminobisphosphonates and Farnesyl Transferase Inhibitors on Tumor Metastasis (2002) (23)
- Breakthrough in bone: the molecular mechanism of osteoclast/osteoblast coupling revealed (2000) (23)
- Titanium particles stimulate COX-2 expression in synovial fibroblasts through an oxidative stress-induced, calpain-dependent, NF-kappaB pathway. (2009) (23)
- Parathyroid Hormone-Related Peptide Expression in Cartilaginous Tumors (2002) (23)
- Loss of Dnmt3b in Chondrocytes Leads to Delayed Endochondral Ossification and Fracture Repair (2018) (23)
- Effects of transforming growth factor-beta on matrix synthesis by chick growth plate chondrocytes. (1988) (22)
- Differential effects of parathyroid hormone on chick growth plate and articular chondrocytes (2004) (22)
- PGE2 Receptor Subtype 1 (EP1) Regulates Mesenchymal Stromal Cell Osteogenic Differentiation by Modulating Cellular Energy Metabolism (2017) (22)
- NF-kappa B regulates VCAM-1 expression on fibroblast-like synoviocytes. (2000) (22)
- Inhibition of 4-aminobutyrate aminotransferase protects against injury-induced osteoarthritis in mice. (2019) (22)
- Notch signaling in postnatal joint chondrocytes, but not subchondral osteoblasts, is required for articular cartilage and joint maintenance. (2016) (22)
- ATF-2 cooperates with Smad3 to mediate TGF-beta effects on chondrocyte maturation. (2003) (21)
- TGF‐β1 Suppresses Plasmin and MMP Activity in Flexor Tendon Cells via PAI‐1: Implications for Scarless Flexor Tendon Repair (2015) (21)
- Growth plate chondrocyte maturation is regulated by basal intracellular calcium. (2002) (21)
- A Rapid Multiparameter Approach to Study Factors that Regulate Osteoclastogenesis: Demonstration of the Combinatorial Dominant Effects of TNF-α and TGF-ß in RANKL-Mediated Osteoclastogenesis (2003) (21)
- Short-term and Long-term Orthopaedic Issues in Patients With Fragility Fractures (2011) (20)
- Sphingomyelinase mediates macrophage activation by titanium particles independent of phagocytosis: A role for free radicals, NFkB, and TNFα (2005) (19)
- Transient gamma-secretase inhibition accelerates and enhances fracture repair likely via Notch signaling modulation. (2015) (19)
- Parathyroid hormone 1–34 enhances extracellular matrix deposition and organization during flexor tendon repair (2015) (18)
- Ablation of Dnmt3b in chondrocytes suppresses cell maturation during embryonic development (2018) (18)
- Identification and characterization of a unique chondrocyte gene involved in transition to hypertrophy. (1996) (17)
- Tamoxifen-inducible CreER-mediated gene targeting in periosteum via bone-graft transplantation. (2008) (17)
- Bone Tissue Engineering: Clinical Challenges and Emergent Advances in Orthopedic and Craniofacial Surgery (2014) (17)
- Role of Pentoxifylline in Preventing Radiation Damage to Epiphyseal Growth Plate Chondrocytes (2002) (17)
- Unique angiogenic and vasculogenic properties of renal cell carcinoma in a xenograft model of bone metastasis are associated with high levels of vegf‐a and decreased ang‐1 expression (2012) (16)
- Case report 830: Aneurysmal bone cyst. (1994) (16)
- American Society for Bone and Mineral Research‐Orthopaedic Research Society Joint Task Force Report on Cell‐Based Therapies (2019) (16)
- Systemic EP4 Inhibition Increases Adhesion Formation in a Murine Model of Flexor Tendon Repair (2015) (16)
- What experimental approaches (eg, in vivo, in vitro, tissue retrieval) are effective in investigating the biologic effects of particles? (2008) (16)
- How do you know it is true? Integrity in research and publications: AOA critical issues. (2015) (15)
- The orthopaedic genome: what does the future hold and are we ready? (2002) (15)
- Differential expression of biological effects in maturationally distinct subpopulations of growth plate chondrocytes. (1990) (15)
- Functional integration of tissue-engineered bone constructs. (2004) (15)
- Loss of the PGE2 receptor EP1 enhances bone acquisition, which protects against age and ovariectomy-induced impairments in bone strength. (2015) (14)
- Epigenetic and therapeutic implications of dnmt3b in temporomandibular joint osteoarthritis. (2019) (14)
- BMP‐TAK1 (MAP3K7) Induces Adipocyte Differentiation Through PPARγ Signaling (2017) (14)
- Case report 830 (1994) (14)
- Autocrine regulation of articular cartilage. (1998) (13)
- Low-Dose and Short-Duration Matrix Metalloproteinase 9 Inhibition Does Not Affect Adhesion Formation during Murine Flexor Tendon Healing (2016) (13)
- Local and neurally mediated effects of sufentanil on canine skeletal muscle vascular resistance. (1987) (12)
- Inflammatory Response of Articular Cartilage to Femoroacetabular Impingement in the Hip (2020) (12)
- Pharmacologic modulators of fracture healing: the role of cyclooxygenase inhibition. (2003) (12)
- Demonstrating the value of orthopaedic surgery through multicenter trials: AOA critical issues. (2015) (12)
- Regulation of embryonic endochondral ossification by Smurf2 (2008) (12)
- Regulation of Chondrocyte Differentiation (2004) (11)
- Safety of Overlapping Inpatient Orthopaedic Surgery: A Multicenter Study (2018) (11)
- High Incidence of Hemiarthroplasty for Shoulder Osteoarthritis Among Recently Graduated Orthopaedic Surgeons (2014) (11)
- Effect of transforming growth factor-β on DNA synthesis by growth plate chondrocytes: Modulation by factors present in serum (1988) (11)
- Teriparatide (human PTH1-34) compensates for impaired fracture healing in COX-2 deficient mice. (2018) (11)
- Increased insulin mRNA binding protein-3 expression correlates with vascular enhancement of renal cell carcinoma by intravenous contrast-CT and is associated with bone metastasis (2015) (11)
- Clinical relevance of increased retinoid and cAMP transcriptional programs in tumor cells rendered non-malignant by dominant negative inhibition of NFkappaB. (2003) (10)
- Peripheral Blood Stem Cell Therapy Does Not Improve Outcomes of Femoral Head Osteonecrosis With Cap‐Shaped Separated Cartilage Defect (2020) (10)
- Factors impacting musculoskeletal knowledge and clinical confidence in graduating medical students. (2014) (10)
- Lead Toxicity in the Skeleton and Its Role in Osteoporosis (2004) (9)
- Regulation of osteoclastic activity in infection. (1994) (9)
- Safety and efficacy of ultraviolet-a light-activated gene transduction for gene therapy of articular cartilage defects. (2006) (9)
- Dnmt3b ablation impairs fracture repair through upregulation of Notch pathway. (2020) (9)
- Parathyroid hormone‐related peptide regulation of chick tibial growth plate chondrocyte maturation requires protein kinase A (2002) (9)
- Deletion of Glut1 in early postnatal cartilage reprograms chondrocytes toward enhanced glutamine oxidation (2021) (9)
- Current concepts review: The biology of the growth plate (2003) (9)
- American Society for Bone and Mineral Research‐Orthopaedic Research Society Joint Task Force Report on Cell‐Based Therapies – Secondary Publication (2020) (8)
- Bone implant interface, osteolysis and potential therapies. (2004) (7)
- IN SITU HYBRIDIZATION IN SKELETAL TISSUES UTILIZING NON-RADIOACTIVE PROBES (1997) (7)
- Distinct Pattern of Inflammation of Articular Cartilage and the Synovium in Early and Late Hip Femoroacetabular Impingement (2020) (7)
- TGF- β SIGNALING IN CHONDROCYTES (2004) (7)
- Osteoporosis in Men. The Effects of Gender on Skeletal Health. (2001) (7)
- Scholarly Success of Orthopaedic Surgeons Participating in the Clinician Scholar Career Development Program (2018) (7)
- Sphingomyelinase mediates macrophage activation by titanium particles independent of phagocytosis: a role for free radicals, NFkappaB, and TNFalpha. (2005) (7)
- Patient-Reported Outcomes Measurement Information System physical function correlates with Toronto Extremity Salvage Score in an orthopaedic oncology population☆☆☆ (2019) (7)
- NFκB: a pivotal transcription factor in prostate cancer metastasis to bone1 (2004) (7)
- Cyclooxygenase-2 deficiency causes delayed ossification of lumbar vertebral endplates. (2018) (6)
- Murine Model of Oligotrophic Tibial Nonunion (2011) (6)
- In vivo prostaglandin E 2 treatment alters the bone marrow microenvironment and preferentially expands short-term hematopoietic stem cells (2009) (6)
- Variation in the Delivery of Inpatient Orthopaedic Care to Medicaid Beneficiaries within a Single Metropolitan Region. (2019) (6)
- RNA-Seq analysis of chondrocyte transcriptome reveals genetic heterogeneity in LG/J and SM/J murine strains. (2020) (6)
- Chapter 11. Skeletal Healing (2009) (6)
- Multiple drug resistance in osteosarcoma. (1995) (5)
- Embracing Differences to Improve Success: American Orthopaedic Association Presidential Address, Boston, Massachusetts, June 23, 2017: AOA Critical Issues. (2019) (5)
- Digital Commons@Becker How do you know it is true? Integrity in research and publications (2014) (5)
- Bilateral sacroiliac joint fracture-dislocation requiring late coccygectomy: a case report. (1992) (5)
- 70 RBPJK-DEPENDENT NOTCH SIGNALING IS REQUIRED FOR ARTICULAR CARTILAGE AND JOINT MAINTENANCE (2011) (5)
- Functional Assessment of Engineered Tissues and Elements of Tissue Design (2002) (5)
- A mouse model of flexor tendon repair. (2014) (5)
- Inhibition of the Prostaglandin EP-1 Receptor in Periosteum Progenitor Cells Enhances Osteoblast Differentiation and Fracture Repair (2019) (5)
- Prostaglandin E2 (PGE2) Treatment Rapidly Increases the Fraction of Non-Dividing Hematopoietic Stem Cells (HSCs) (2008) (4)
- Treatment of multifocal lymphoma of bone with intensified Promace‐Cytabom chemotherapy and involved field radiotherapy (1998) (4)
- Treatment of intra-articular hip malignancy with extra-articular resection, preservation of the acetabular columns, and total hip arthroplasty (2018) (4)
- Clinical translation and application in orthopaedics (2017) (4)
- Malic Enzyme 1 Absence in Synovial Sarcoma Shifts Antioxidant System Dependence and Increases Sensitivity to Ferroptosis Induction with ACXT-3102 (2022) (3)
- Patient Report Improves Posthospital Discharge Event Capture in Total Joint Replacement: A Novel Approach to Capturing All Posthospital Event Data (2014) (3)
- A genome‐wide expression profile and system‐level integration of nuclear factor kappa B regulated genes reveals fundamental metabolic adaptations during cell growth and survival (2005) (3)
- Cyclooxygenases and bone repair (2001) (3)
- LDHA-mediated ROS generation in chondrocytes is a potential therapeutic target for osteoarthritis (2020) (2)
- Conditional Activation of β -Catenin Signaling Leads to Severe Defects in Intervertebral Disc Tissue (2013) (2)
- Bone metastasis: an update on mechanisms of bone resorption and therapeutic strategies (2000) (2)
- Otto Aufranc Award: Identification of Key Molecular Players in the Progression of Hip Osteoarthritis through Transcriptomes and Epigenetics. (2022) (2)
- Summary--Cell therapies for orthopedic applications. (2005) (2)
- PL6Cellular and molecular targets to enhance fracture healing and bone formation in aging (2010) (2)
- Orthopaedic basic science: Foundations of clinical practice, fourth edition (2018) (2)
- Alternative Splicing of a Chondrocyte‐Specific Gene (1996) (1)
- Clinician-directed treatment guidelines (2019) (1)
- COMPARISON OF AUTO , ISO , AND ALLOGRAFTS AND THE EFFECT (2002) (1)
- Measurement of pelvic osteolytic lesions in follow-up studies after total hip arthroplasty (2006) (1)
- The impact of translational orthopaedic research: Journal of Orthopaedic Translation indexed in Science Citation Index Expanded (2018) (1)
- Did the Physical and Mental Health of Orthopaedic Patients Change After the Onset of the COVID-19 Pandemic? (2023) (1)
- Endogenous tissue engineering: PTH therapy for skeletal repair (2011) (1)
- Determination of Responsiveness in Biological Systems Is Dependent on Highly Sensitive Quantitative Measures (2002) (1)
- Methylation of 4-aminobutyrate aminotransferase (ABAT) by dnmy3b regulates chondrocytes metabolism and the development of osteoarthritis (OA) (2018) (1)
- Differential Effects of Parathyroid Hormone on Chick and Articular Chondrocytes (1992) (1)
- A Novel Animal Model To Study Capsular Contracture Utilizing Livescan MicroCT Technology (2009) (1)
- Semi-automated CT-based analysis of regional bone-density in contra lateral total hip replacement (2004) (1)
- Biology Summary (2008) (1)
- Location of All-cause 30-day Readmission Following Total Joint Replacement: Surgical Hospital Versus Outside Hospital (2015) (1)
- Prostaglandin E2 (PGE2) Regulates Osteoblastic Jagged1 and Expands Primitive Hematopoietic Cells In Vivo. (2006) (1)
- Postnatal β-catenin conditional activation mice display severe defects in intervertebral disc tissue with significant loss of growth plate cartilage and extensive osteophyte formation (2011) (1)
- Aberrant hypertrophy in Smad3-deficient chondrocytes is rescued by restoring TAK1-ATF-2 signaling: a potential clinical implication for osteoarthritis (2011) (1)
- GSK-3 Inhibitor BIO Stimulates Osteoblast Differentiation and Bone Formation (2002) (0)
- Letter to the Editor: Not the Last Word: Prizes for Cures. (2019) (0)
- Reduced Anabolic Response To Parathyroid Hormone In Periosteal Mesenchymal Stem Cells From Aged Mice (2015) (0)
- Differential Mmp response to PGE2 during flexor tendon healing (2008) (0)
- Inhibition of the Prostaglandin EP-1 Receptor in Periosteum Progenitor Cells Enhances Osteoblast Differentiation and Fracture Repair (2019) (0)
- TGFB IN CHONDROCYTE BIOLOGY AND CARTILAGE PATHOLOGY (2005) (0)
- Intraarticular Inflammation and Catabolic Markers in Femoroacetabular Impingement during Progression of Disease -comparison between early and late stage disease- (2020) (0)
- In Vivo Treatment with Prostaglandin E2 (PGE2) Selectively Expands Short-Term Hematopoietic Stem Cells. (2007) (0)
- The Validity of Patient-Reported Short-Term Complications following Total Hip and Knee Arthroplasty (2014) (0)
- Cells Regulate Tumor Burden and Osteolysis in Bone Dependent Mechanisms in Breast Cancer − B κ Nuclear Factor-Updated (2005) (0)
- Fibroblast-Like Synoviocytes B Regulates VCAM-1 Expression on κ NF - (2000) (0)
- 4-Aminobutyrate aminotransferase regulates chondrocyte homeostasis and can be targeted using peptide-sirna nanoparticles to attenuate osteoarthritis in a murine injury model (2021) (0)
- Basic science of immunology in orthopaedics (2018) (0)
- Poster 196: Articular Chondrocytes in Hip Femoroacetabular Impingement Present a Less Catabolic Phenotype than Late Stage of Disease (2022) (0)
- Role Of Mitochondria In Mesenchymal Stem Cells (2014) (0)
- Epigenetic Dysregulation of Articular Cartilage during Progression of Hip Femoroacetabular Impingement Disease. (2023) (0)
- Primary Soft-tissue Sarcomas: Predictors of Local Disease Recurrence, Distant Metastasis, and Overall Survival After Limb-sparing Surgery and Radiation Therapy (2012) (0)
- Conditional activation of the β-catenin gene in articular chondrocytes in adult mice leads to osteoarthritis-like phenotype (2008) (0)
- The Role of Prostanoid Receptor EP 4 on Adhesion Formation in Flexor Tendon Healing-Differential Effects of Tendon-Specific Deletion Versus Systemic Antagonism (2015) (0)
- Bone tissue engineering (2020) (0)
- TGF-β 1 Decreases Plasmin-Mediated MMP Activity in Flexor Tendon Cells : Implications for Scarless Tendon Repair (2013) (0)
- Novel Hip Osteoarthritis Model Secondary To Femoroacetabular Impingement In Immature Rabbits (2023) (0)
- TGFβ signaling maintains articular chondrocyte homeostasis by reprogramming glucose metabolism (2019) (0)
- Isolation and Culture of Periosteum-Derived Progenitor Cells from Mice. (2021) (0)
- Pparγ Promoter Demethylation Rescues Articular Chondrocytes From Catabolic State In Hip Fai (2023) (0)
- On the Horizon From the ORS (2006) (0)
- PTH Promotes Angiogenic Differentiation of Intravenous Delivery Mesenchymal Stem Cell During Bone Repair May via VEGF Induction (2014) (0)
- DNA methyltransferase 3B regulates articular cartilage homeostasis by altering chondrocyte metabolism (2016) (0)
- In Memory of Prof. Harry Genant, MD/PhD (2021) (0)
- Deletion of EP4 in S100a4-lineage cells reduces scar tissue formation during early but not later stages of tendon healing (2017) (0)
- Fibroblast-Specific Deletion Of Tak 1 Reduces Adhesion Formation During Flexor Tendon Healing Via Inhibition Of Myofibroblast Activation (2014) (0)
- Radiation injury to growth plate/epiphyseal chondrocytes: molecular mechanisms (2000) (0)
- Basic principles of orthopaedic surgery (2018) (0)
- Gene polymorphisms and musculoskeletal disease (2001) (0)
- SYMPOSIUM: NEW APPROACHES TO ALLOGRAFT TRANSPLANTATION (2008) (0)
- Epigenetic Dysregulation During The Oa Progression In Hip Fai (2023) (0)
- Poster 197: Understanding the Biological Pathway of Progression of Hip OA Disease through Transcriptome Analysis (2022) (0)
- through an oxidative stress-induced, calpain-dependent, NF-kappa B pathway (2009) (0)
- Letter to the Editor: Not the Last Word: Prizes for Cures. (2019) (0)
- The Effects of PGE2-Receptor Deletion on Fracture Healing (2011) (0)
- An AAOS-ORS Symposium: Molecular Biology and Therapeutics in Musculoskeletal Oncology (2009) (0)
- Development of siRNA Technology to Prevent Scar Formation in Tendon Repair (2012) (0)
- Assessment of the performance of engineered tissues in humans requires the development of highly sensitive and quantitative noninvasive outcome measures (2003) (0)
- P38-ATF2 Signaling Regulates Chondrocyte Maturation: the potential novel therapeutics for osteoarthritis (2006) (0)
- Characterization of band 17, a growth plate-specific gene in chick; and mapping of its human homolog, GPTP1 (1996) (0)
- 19 Radiation effects on growth factor expression and chondrocyte regulation in the epiphyseal growth plate (1996) (0)
- A Novel Model of Hip Femoroacetabular Impingement in Immature Rabbits Reproduces the Distinctive Head-Neck Cam Deformity (2022) (0)
- Teriparatide (human PTH 1–34 ) Compensates for Impaired Fracture Healing in COX-2 Deficient Mice (2018) (0)
- Bone density changes following radiation for extremity sarcomas (2002) (0)
This paper list is powered by the following services:
