Reinhart Heinrich | Academic Influence

Reinhart Heinrich's AcademicInfluence.com Rankings

Reinhart Heinrich

Physics

#4398

World Rank

#6051

Historical Rank

Biophysics

#196

World Rank

#206

Historical Rank

physics Degrees

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Physics

Reinhart Heinrich's Degrees

PhD Physics University of Göttingen

Why Is Reinhart Heinrich Influential?

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According to Wikipedia, Reinhart Heinrich was a German biophysicist. He was professor at the Humboldt University of Berlin, and best known as one of the founders, with Tom Rapoport, of metabolic control theory in parallel with similar ideas developed at about the same time by Henrik Kacser and Jim Burns. His far-reaching theoretical work on metabolism, signal transduction, and other cellular processes has made him one of the most influential forerunners of present-day systems biology. Reinhart's many talents made him appear as a modern Renaissance man. He played the violin, and published an autobiographic novel and several works of lyric poetry for which he received the Brigitte Reimann Prize. Among his services to the scientific community, Reinhart was associate editor of PLoS Computational Biology.

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Reinhart Heinrich's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

The Regulation of Cellular Systems (1996) (1285)
A linear steady-state treatment of enzymatic chains. General properties, control and effector strength. (1974) (1281)
The Roles of APC and Axin Derived from Experimental and Theoretical Analysis of the Wnt Pathway (2003) (698)
Mathematical models of protein kinase signal transduction. (2002) (515)
Metabolic regulation and mathematical models. (1977) (489)
Metabolic Pathway Analysis: Basic Concepts and Scientific Applications in the Post‐genomic Era (1999) (407)
Biological Control through Regulated Transcriptional Coactivators (2004) (373)
Control of MAPK signalling: from complexity to what really matters (2005) (207)
A linear steady-state treatment of enzymatic chains. A mathematical model of glycolysis of human erythrocytes. (1974) (188)
Expanding Metabolic Networks: Scopes of Compounds, Robustness, and Evolution (2005) (181)
Principles behind the multifarious control of signal transduction (2004) (177)
The regulatory principles of glycolysis in erythrocytes in vivo and in vitro. A minimal comprehensive model describing steady states, quasi-steady states and time-dependent processes. (1976) (175)
A Linear Steady-State Treatment of Enzymatic Chains Critique of the Crossover Theorem and a General Procedure to Identify Interaction Sites with an Effector (1974) (172)
Control analysis of metabolic systems (1985) (169)
Complex calcium oscillations and the role of mitochondria and cytosolic proteins. (2000) (155)
Mathematical analysis of enzymic reaction systems using optimization principles. (1991) (150)
Primary mouse hepatocytes for systems biology approaches: a standardized in vitro system for modelling of signal transduction pathways. (2006) (139)
Mathematical analysis of multienzyme systems. II. Steady state and transient control. (1975) (131)
Protein phosphatase 1 regulates assembly and function of the β‐catenin degradation complex (2007) (128)
The kinetic basis of threshold effects observed in mitochondrial diseases: a systemic approach. (1994) (126)
Intercellular Ca2+ wave propagation through gap-junctional Ca2+ diffusion: a theoretical study. (2001) (123)
Transduction of intracellular and intercellular dynamics in yeast glycolytic oscillations. (2000) (121)
Prediction of temporal gene expression. Metabolic opimization by re-distribution of enzyme activities. (2002) (119)
Structural analysis of expanding metabolic networks. (2004) (107)
Hexokinase of human erythrocytes. Purification, kinetic model and its application to the conditions in the cell. (1974) (104)
Mathematical modelling of the within-host dynamics of Plasmodium falciparum (2000) (101)
Mathematical modelling of translation of mRNA in eucaryotes; steady state, time-dependent processes and application to reticulocytes. (1980) (98)
Quasi-steady-state approximation in the mathematical modeling of biochemical reaction networks (1983) (96)
The modelling of metabolic systems. Structure, control and optimality. (1998) (96)
GATA-3 transcriptional imprinting in Th2 lymphocytes: A mathematical model (2002) (94)
Evolutionary optimization of metabolic pathways. Theoretical reconstruction of the stoichiometry of ATP and NADH producing systems (2001) (91)
Theoretical approaches to the evolutionary optimization of glycolysis--chemical analysis. (1997) (85)
Theoretical approaches to the evolutionary optimization of glycolysis: thermodynamic and kinetic constraints. (1997) (80)
Dynamics of two-component biochemical systems in interacting cells; synchronization and desynchronization of oscillations and multiple steady states. (1997) (75)
Mathematical modeling of nucleotide excision repair reveals efficiency of sequential assembly strategies. (2005) (75)
Smallest chemical reaction system with Hopf bifurcation (1995) (74)
A linear steady-state treatment of enzymatic chains. Critique of the crossover theorem and a general procedure to identify interaction sites with an effector. (1974) (73)
Linear theory of enzymatic chains; its application for the analysis of the crossover theorem and of the glycolysis of human erythrocytes. (1973) (73)
Generation of nonidentical compartments in vesicular transport systems (2005) (69)
Effect of cellular interaction on glycolytic oscillations in yeast: a theoretical investigation. (2000) (66)
Birhythmicity, trirhythmicity and chaos in bursting calcium oscillations. (2001) (62)
The definitions of metabolic control analysis revisited. (1992) (61)
Ratcheting in post-translational protein translocation: a mathematical model. (2001) (60)
Effect of cellular interaction on glycolytic oscillations in yeast: a theoretical investigation (2000) (58)
Minimization of intermediate concentrations as a suggested optimality principle for biochemical networks (1991) (58)
Analysis of the quasi-steady-state approximation for an enzymatic one-substrate reaction. (1979) (57)
Competition for enzymes in metabolic pathways: implications for optimal distributions of enzyme concentrations and for the distribution of flux control. (1999) (57)
Temperature dependency and temperature compensation in a model of yeast glycolytic oscillations. (2003) (56)
Model reduction and analysis of robustness for the Wnt/beta-catenin signal transduction pathway. (2004) (56)
Formation of large clusters during sputtering of silver (2000) (56)
Time hierarchy in enzymatic reaction chains resulting from optimality principles. (1987) (54)
Metabolic control analysis of relaxation processes (1991) (53)
The electric potential profile across the erythrocyte membrane. (1982) (49)
Building functional modules from molecular interactions. (2006) (49)
Minimization of intermediate concentrations as a suggested optimality principle for biochemical networks (1991) (49)
Mathematical analysis of a mechanism for autonomous metabolic oscillations in continuous culture of Saccharomyces cerevisiae (2001) (49)
A mathematical model for the influence of fructose 6-phosphate, ATP, potassium, ammonium and magnesium on the phosphofructokinase from rat erythrocytes;. (1974) (48)
A theoretical approach to the evolution and structural design of enzymatic networks: linear enzymatic chains, branched pathways and glycolysis of erythrocytes. (1987) (48)
Experiment and simulation of cluster emission from 5 keV Ar → Cu (1998) (47)
A metabolic osmotic model of human erythrocytes. (1984) (47)
Modeling the interrelations between the calcium oscillations and ER membrane potential oscillations. (1997) (46)
Histone deacetylase inhibitor Helminthosporium carbonum (HC)‐toxin suppresses the malignant phenotype of neuroblastoma cells (2007) (46)
Optimal stoichiometric designs of ATP-producing systems as determined by an evolutionary algorithm. (1999) (44)
Analysing the robustness of cellular rhythms. (2005) (43)
Stoichiometric design of metabolic networks: Multifunctionality, clusters, optimization, weak and strong robustness (2003) (43)
Acoustic transmission characteristics of the tympanal tracheae of bushcrickets (Tettigoniidae). II: Comparative studies of the tracheae of seven species (1993) (42)
Mathematical analysis of multienzyme systems. I. Modelling of the glycolysis of human erythrocytes. (1975) (42)
Identified descending brain neurons control different stridulatory motor patterns in an acridid grasshopper (1997) (42)
Agonistic behavior in naïve juvenile lobsters depleted of serotonin by 5,7-dihydroxytryptamine (2001) (42)
A cross species comparison of metabolic network functions. (2005) (41)
Mathematical modeling of the effects of the signal recognition particle on translation and translocation of proteins across the endoplasmic reticulum membrane. (1987) (41)
Kinetic parameters of enzymatic reactions in states of maximal activity; an evolutionary approach. (1991) (41)
A role for muscarinic excitation: Control of specific singing behavior by activation of the adenylate cyclase pathway in the brain of grasshoppers (2001) (39)
Control analysis of unbranched enzymatic chains in states of maximal activity. (1996) (39)
Impact of descending brain neurons on the control of stridulation, walking, and flight in orthoptera (2002) (38)
Evolutionary optimization of enzyme kinetic parameters; effect of constraints. (1994) (38)
Defining control coefficients in non-ideal metabolic pathways. (1995) (37)
Pharmacological brain stimulation releases elaborate stridulatory behaviour in gomphocerine grasshoppers – conclusions for the organization of the central nervous control (2001) (37)
A second-order approach to metabolic control analysis. (1993) (36)
Nitric oxide/cyclic guanosine monophosphate signaling in the central complex of the grasshopper brain inhibits singing behavior (2005) (36)
Erythropoietin promotes survival and regeneration of insect neurons in vivo and in vitro (2011) (36)
Optimization of Glycolysis: A New Look at the Efficiency of Energy Coupling (1997) (35)
An evolutionary approach to enzyme kinetics: Optimization of ordered mechanisms (1994) (35)
A kinetic model for the interaction of energy metabolism and osmotic states of human erythrocytes. Analysis of the stationary "in vivo" state and of time dependent variations under blood preservation conditions. (1985) (35)
Common Variants of the Genes Encoding Erythropoietin and Its Receptor Modulate Cognitive Performance in Schizophrenia (2012) (34)
Circadian Regulation of Agonistic Behavior in Groups of Parthenogenetic Marbled Crayfish, Procambarus sp. (2009) (34)
Sound production during agonistic behavior of male Drosophila melanogaster (2011) (33)
Metabolic optimization by re-distribution of enzyme activities (2002) (32)
Optimization of glycolysis: new discussions (1999) (32)
A theory of optimal differential gene expression. (2004) (32)
Autoinhibition of serotonin cells: an intrinsic regulatory mechanism sensitive to the pattern of usage of the cells. (1999) (31)
Erythropoietin-mediated protection of insect brain neurons involves JAK and STAT but not PI3K transduction pathways (2014) (31)
Monogenic heritable autism gene neuroligin impacts Drosophila social behaviour (2013) (30)
Kinetic and thermodynamic principles determining the structural design of ATP-producing systems (1998) (30)
Mathematical analysis of the smallest chemical reaction system with Hopf bifurcation (1996) (28)
A Three Dimensional Dual-Time-Stepping Method for the Solution of the Unsteady Navier-Stokes Equations (1996) (27)
Interrelations between dynamical properties and structural characteristics of signal transduction networks. (2004) (25)
Self-sputtering of silver by mono- and polyatomic projectiles: A molecular dynamics investigation (2001) (25)
mAChRs in the grasshopper brain mediate excitation by activation of the AC/PKA and the PLC second-messenger pathways. (2002) (25)
Reproductive behaviour of female Chorthippus biguttulus grasshoppers. (2010) (24)
Neurochemical Architecture of the Central Complex Related to Its Function in the Control of Grasshopper Acoustic Communication (2011) (24)
The utility of mathematical models for the understanding of metabolic systems. (1983) (24)
Muscarinic Excitation in Grasshopper Song Control Circuits Is Limited by Acetylcholinesterase Activity (2007) (24)
Dynamics of non-linear biochemical systems and the evolutionary significance of time hierarchy. (1982) (24)
Suppression of grasshopper sound production by nitric oxide-releasing neurons of the central complex (2008) (24)
Modelling oscillations of calcium and endoplasmic reticulum transmembrane potential: Role of the signalling and buffering proteins and of the size of the Ca2+ sequestering ER subcompartments (1998) (24)
Recognition, presence, and survival of locust central nervous glia in situ and in vitro (2009) (22)
Neuropharmacological evidence for inhibitory cephalic control mechanisms of stridulatory behaviour in grasshoppers (1998) (21)
The atomic configuration of screw dislocations in the b.c.c. lattice (1971) (19)
Nonequilibrium configurations and peierls potential of screw dislocations in the b.c.c. lattice (1971) (19)
Modelling of phospholipid translocation in the erythrocyte membrane: a combined kinetic and thermodynamic approach. (1997) (18)
The structural design of glycolysis: an evolutionary approach. (1999) (18)
Aminergic neuron systems of lobsters: morphology and electrophysiology of octopamine-containing neurosecretory cells (2000) (18)
Analysis of the selection equations for a multivariable population model. Deterministic and stochastic solutions and discussion of the approach for populations of self-reproducing biochemical networks (1981) (18)
Is metabolic channelling the complicated solution to the easy problem of reducing transient times? (1991) (18)
Efficiency and design of simple metabolic systems. (1985) (17)
Erythropoietin dampens injury-induced microglial motility (2015) (17)
[Mathematical modelling of glycolysis and adenine nucleotide metabolism of human erythrocytes. I. Reaction-kinetic statements, analysis of in vivo state and determination of starting conditions for in vitro experiments]. (1981) (16)
Central nervous control of hindleg coordination in stridulating grasshoppers (1997) (16)
Nearly spherical vesicle shapes calculated by use of spherical harmonics : axisymmetric and nonaxisymmetric shapes and their stability (1992) (16)
Mathematical models of metabolic systems: general principles and control of glycolysis and membrane transport in erythrocytes. (1985) (15)
Reproduction-Related Sound Production of Grasshoppers Regulated by Internal State and Actual Sensory Environment (2012) (14)
Tracing of a neuronal network in the locust by pressure injection of markers into a synaptic neuropil (1998) (14)
Hierarchy of metabolic compounds based on their synthesising capacity. (2006) (14)
Projectile size effects on cluster formation in sputtering (2003) (14)
The circadian biology of the marbled crayfish. (2010) (14)
Homology of insect corpora allata and vertebrate adenohypophysis? (2012) (13)
Calculation of kinetic parameters of a reversible enzymatic reaction in states of maximal activity. (1990) (13)
Free energy of the electrostatic interaction of cells with adjacent charged glycoprotein layer: a theoretical approach. (1982) (13)
A mathematical model for the influence of anionic effectors on the phosphofructokinase from rat erythrocytes. (1977) (13)
On the temperature dependence of sputtered cluster yields (2000) (12)
An extended model of the glycolysis in erythrocytes. (1977) (12)
Metabolic Control Analysis (1996) (11)
Bestimmung von Cadmium in Harn durch ETAAS nach Extraktion (1983) (11)
Kinetic and thermodynamic aspects of lipid translocation in biological membranes. (1999) (10)
In vivo labeling and in vitro characterisation of central complex neurons involved in the control of sound production (2009) (10)
Bestimmung von Cobalt in Blut mit Hilfe der elektrothermalen Atomabsorptionsspektrometrie (1984) (10)
Notfallbehandlung von Blutungskomplikationen bei Hemmkörper-Hämophilie mit aktivierten Prothrombinkomplex-Konzentraten (1977) (10)
Cluster formation under bombardment with polyatomic projectiles (2000) (9)
Soil erosion on a sub-tropical coastal dune complex, Transkei, Southern Africa (1991) (9)
Dynamic Stability of Signal Transduction Networks Depending on Downstream and Upstream Specificity of Protein Kinases (2004) (9)
Regulation of anaerobic glycolysis in Ehrlich ascites tumour cells. (1977) (7)
Postactivation inhibition of spontaneously active neurosecretory neurons in the medicinal leech (2007) (7)
Optimization of kinetic parameters of enzymes (2002) (7)
Intracellular signal propagation in a two-dimensional autocatalytic reaction model. (2002) (7)
The electric potential across the erythrocyte membrane: a mathematical model. (1981) (6)
Metabolic Control Analysis: Principles and Application to the Erythrocyte (1990) (6)
Multielectrode recordings from auditory neurons in the brain of a small grasshopper (2015) (6)
Identification of Auditory Interneurons In Situ and In Vitro by Tracer Injection into an Afferent Neuropil of Locusta migratoria (1998) (6)
Mini review: Multielectrode recordings in insect brains (2015) (6)
Nitric oxide/cGMP signaling in the corpora allata of female grasshoppers. (2011) (5)
LuFo Verbundvorhaben AeroStruct: Enable and Learn how to Integrate Flexibility in Design (2015) (5)
Numerical Prediction of Dynamic Derivatives for Lifting Bodies with a Navier-Stokes Solver (1999) (5)
Dynamics of biochemical oscillators in a large number of interacting cells (1997) (5)
Nitric oxide/cyclic GMP signaling and insect behavior (2007) (5)
Application of GTEM cells for IC EMC testing (2008) (5)
Carrier-mediated residual K++ and Na++ transport of human red blood cells (1993) (4)
Influence of calcium binding to proteins on calcium oscillations and ER membrane potential oscillations: a mathematical model (1998) (4)
Structural and dynamical analyses of the kinase network derived from the transpath database. (2005) (4)
Compensating lipid fluxes generated by the aminophospholipid translocase. (1998) (4)
Mathematical modelling of lipid transbilayer movement in the human erythrocyte plasma membrane (2004) (4)
Influence of Internal Stress on Thermally Activated Dislocation Motion in the Peierls Potential (1970) (4)
Principles behind the multifarious control of signal (2005) (4)
[Mathematical modelling of glycolysis and of adenine nucleotide metabolism of human erythrocytes. II. Simulation of adenine nucleotide breakdown following glucose depletion]. (1981) (3)
Pharmacological Activation of Stridulation in the Grasshopper Chorthippus albomarginatus (Orthoptera: Gomphocerinae) (2001) (3)
Expansion of signal transduction networks. (2006) (3)
Long-Term Culture of Lobster Central Ganglia: Expression of Foreign Genes in Identified Neurons. (1999) (3)
Can biochemical properties serve as selective pressure for gene selection during inter-species and endosymbiotic lateral gene transfer? (2006) (3)
Control of Threonine Biosynthesis in E. Coli (1993) (2)
[Pharmacological activation of stridulation in Chorthippus albomarginatus (Orthoptera, Gomphocerinae)]. (2001) (2)
Mathematical Models of Protein Kinase (2002) (2)
Kinetic models and phenomenological analysis of passive lipid translocation in single-file. (1999) (2)
Kinetic and thermodynamic constraints for the structural design of glycolysis (1997) (2)
A theoretical approach to cluster formation in biological membranes. (1984) (2)
Chemicals by Biomass Pyrolysis in a Fluidized Bed (1993) (2)
Radiated immunity testing of integrated circuits in reverberation chambers (2012) (1)
Henrik Kacser, 1918-1995. (1995) (1)
Diffusion layer caused by local ionic transmembrane fluxes (2006) (1)
CAN WE AGREE ON METABOLIC CONTROL (1985) (1)
The effect of pyruvate on glycolysis and the maintenance of adenine nucleotides in red cells. (1981) (1)
Time Hierarchy in Metabolism (1996) (1)
Theoretical analysis of red cell metabolism and its interaction with membrane transport. (1989) (1)
Screw dislocation kinks in the B.C.C. lattice (1970) (1)
Fundamentals of Biochemical Modeling (1996) (1)
Control and structural design of glycolysis: An evolutionary approach (1999) (1)
Synaptic Connectivity of Amine-Containing Neurosecretory Cells of Lobsters: Inputs to 5HT- and OCT- Containing Neurons (2002) (1)
Norbert Elsner (1940 – 2011) (2011) (1)
Intrinsic Properties of Amine-Containing Neurosecretory Cells of Lobsters: Spontaneous Activity and Autoinhibition (2002) (1)
The Insects: Mechanical communication: producing sound and substrate vibrations (2012) (1)
Patterns of interactions of reaction pairs in metabolic networks. (2006) (1)
The structure of metabolic systems: a theoretical approach. (1990) (0)
Application of Optimization Methods and the Interrelation with Evolution (1996) (0)
A CHEMICAL SYSTEM WITH HOPF BIFURCATION CONSISTING OF THREE INTERMEDIATES AND MONO- AND BIMOLECULAR REACTIONS (1995) (0)
Optimization and Control of Metabolic Systems (1998) (0)
Haiti 3D ladar flights (2011) (0)
Introduction to Session Metabolic Regulatory Systems (1996) (0)
Second-Messenger Pathways by Activation of the AC/PKA and the PLC mAChRs in the Grasshopper Brain Mediate Excitation (2015) (0)
Glycolytic oscillations in spatially ordered interacting cells (2004) (0)
Predicting the Structural Design of Metabolic Pathways: An Evolutionary Approach (2000) (0)
Metabolic Control Theory (1996) (0)
[Early hemodynamic reactions of an ionic low osmolar and a nonionic contrast medium]. (1984) (0)
Investigation of "leak" cation transport of human erythrocytes in dependence on intra- and extracellular ionic conditions (1990) (0)
PRINCIPLES OF METABOLIC CONTROL THEORY (1995) (0)
Mathematical modelling of enzymic systems; simulation, control analysis and optimization (1995) (0)
Integrating business process simulation and information system simulation for performance prediction (2015) (0)
Vibration damping element (1986) (0)
An Extension of Metabolic Control Analysis to Larger Parameter Perturbations by Inclusion of Second-Order Effects (1993) (0)
Zur Namensentstehung bei Cleophana yvanii Dup. (eine Berichtigung), Larentia oxybiata Mill. und Symmoca oxybiella Mill (0)
Influence of calcium binding to proteins on calcium oscillation. A mathematical model (1998) (0)
8.3. Brain NOS activity regulates reproductive state-related behaviors in grasshoppers (2007) (0)
Grafikfähige Taschencomputer in zentralen Prüfungen (2007) (0)
A process for the production of highly elastic filaments (1964) (0)
On the influence of fructose-6-phosphate, ammonium, ATP and AMP on the conformation of the phosphofructokinase from rabbit muscle. (1975) (0)
Mathematical modelling of dynamic lipid asymmetry in the human erythrocyte membrane (1993) (0)
Corrigendum to ‘Monogenic heritable autism gene neuroligin impacts Drosophila social behaviour’ [BBR 252C (2013) 450–457] (2013) (0)
A KINETIC MODEL OF PHOSPHOLIPID TRANSLOCATION IN THE ERYTHROCYTE MEMBRANE (1995) (0)
Topological analysis of metabolic and regulatory networks by decomposition methods (2003) (0)
Erfassung der Notwendigkeit von stationären Behandlungen in der Inneren Medizin - Reproduzierbarkeit eines für Deutschland adaptierten Verfahrens - (2000) (0)
Corrections: The Roles of APC and Axin Derived from Experimental and Theoretical Analysis of the Wnt Pathway (2004) (0)
Optimization of glycolysis: new discussions S0307441298002660 (1999) (0)
Lecture Room: 11 Field: Cell Signalling and Cellular Organization (2002) (0)
Expanding Large Scale Signal Transduction Networks (2005) (0)
Residual Sodium and Potassium Fluxes Through Red Blood Cell Membranes (1996) (0)
Evolutionary Optimization of Enzymes and Metabolic Systems (1997) (0)
Modellierung der freien Solvatisierungsenthalpie und Anwendung als Scoringfunktion (2004) (0)
Structural and Functional Analysis of Transiently Expressed Metabolic Networks (2005) (0)

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