René a. w. Van Lier

René a. w. Van Lier's AcademicInfluence.com Rankings

René a. w. Van Lier

Biology

#11506

World Rank

#14906

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Immunology

#736

World Rank

#758

Historical Rank

biology Degrees

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Biology

René a. w. Van Lier's Degrees

PhD Immunology University of Amsterdam
Masters Biomedical Sciences University of Amsterdam
Bachelors Biomedical Sciences University of Amsterdam

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René a. w. Van Lier's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Phenotypic and Functional Separation of Memory and Effector Human CD8+ T Cells (1997) (1513)
Phenotype and function of human T lymphocyte subsets: Consensus and issues (2008) (747)
Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes (2016) (642)
Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition) (2019) (627)
Primary immune responses to human CMV: a critical role for IFN-gamma-producing CD4+ T cells in protection against CMV disease. (2003) (462)
The seven-span transmembrane receptor CD97 has a cellular ligand (CD55, DAF) (1996) (372)
Emergence of a CD4+CD28− Granzyme B+, Cytomegalovirus-Specific T Cell Subset after Recovery of Primary Cytomegalovirus Infection (2004) (359)
CD20 deficiency in humans results in impaired T cell-independent antibody responses. (2010) (351)
Programs for the persistence, vigilance and control of human CD8+ lung-resident memory T cells (2016) (316)
Constitutive CD27/CD70 interaction induces expansion of effector-type T cells and results in IFNgamma-mediated B cell depletion. (2001) (305)
Timing and tuning of CD27–CD70 interactions: the impact of signal strength in setting the balance between adaptive responses and immunopathology (2009) (291)
Human atopen-specific types 1 and 2 T helper cell clones. (1991) (286)
Regulation of CD27 expression on subsets of mature T-lymphocytes. (1993) (282)
Differentiation of cytomegalovirus-specific CD8(+) T cells in healthy and immunosuppressed virus carriers. (2001) (258)
Engagement of CD27 with its ligand CD70 provides a second signal for T cell activation. (1995) (247)
Tissue distribution and biochemical and functional properties of Tp55 (CD27), a novel T cell differentiation antigen. (1987) (243)
Expression of the Murine CD27 Ligand CD70 In Vitro and In Vivo4 (2003) (238)
Control of lymphocyte function through CD27-CD70 interactions. (1998) (236)
Reconstitution of the T-cell compartment after bone marrow transplantation: restoration of the repertoire by thymic emigrants. (1998) (228)
Leukocyte adhesion deficiency type 1 (LAD-1)/variant. A novel immunodeficiency syndrome characterized by dysfunctional beta2 integrins. (1997) (224)
Evidence that human CD8+CD45RA+CD27- cells are induced by antigen and evolve through extensive rounds of division. (1999) (218)
Faces and phases of human CD8 T-cell development. (1999) (207)
Functional and phenotypic evidence for a selective loss of memory T cells in asymptomatic human immunodeficiency virus-infected men. (1990) (204)
Selective accumulation of differentiated CD8+ T cells specific for respiratory viruses in the human lung (2005) (204)
Development of virus-specific CD4(+) T cells during primary cytomegalovirus infection. (2000) (203)
Tissue-resident memory T cells populate the human brain (2018) (198)
The Noxa/Mcl-1 axis regulates susceptibility to apoptosis under glucose limitation in dividing T cells. (2006) (198)
Neutrophils Kill Antibody-Opsonized Cancer Cells by Trogoptosis. (2018) (189)
Characterization of the human CD27 ligand, a novel member of the TNF gene family. (1994) (188)
IL-7 receptor alpha chain expression distinguishes functional subsets of virus-specific human CD8+ T cells. (2005) (188)
Tumor Rejection Induced by CD70-mediated Quantitative and Qualitative Effects on Effector CD8+ T Cell Formation (2004) (185)
The CD27− subset of peripheral blood memory CD4+ lymphocytes contains functionally differentiated T lymphocytes that develop by persistent antigenic stimulation in vivo (1992) (184)
Clinical and Immunologic Aspects of Cytomegalovirus Infection in Solid Organ Transplant Recipients (2005) (181)
Cure of xenografted human tumors by bispecific monoclonal antibodies and human T cells. (1994) (180)
Frequencies of Circulating Cytolytic, CD45RA+CD27−, CD8+ T Lymphocytes Depend on Infection with CMV1 (2003) (180)
Expression cloning and chromosomal mapping of the leukocyte activation antigen CD97, a new seven-span transmembrane molecule of the secretion receptor superfamily with an unusual extracellular domain. (1995) (179)
Molecular profiling of cytomegalovirus-induced human CD8+ T cell differentiation. (2010) (177)
Tissue-resident memory T cells at the center of immunity to solid tumors (2018) (176)
CD27 Defines Phenotypically and Functionally Different Human NK Cell Subsets (2008) (175)
Proliferation Requirements of Cytomegalovirus-Specific, Effector-Type Human CD8+ T Cells1 (2002) (175)
IL-15 induces antigen-independent expansion and differentiation of human naive CD8+ T cells in vitro. (2003) (172)
CD27: marker and mediator of T-cell activation? (1994) (169)
CD103 Is a Marker for Alloantigen-Induced Regulatory CD8+ T Cells (2006) (168)
Defective TCR-mediated signaling in synovial T cells in rheumatoid arthritis. (1997) (164)
Human cytomegalovirus induces systemic immune activation characterized by a type 1 cytokine signature. (2010) (155)
CD8⁺ T cells with an intraepithelial phenotype upregulate cytotoxic function upon influenza infection in human lung. (2011) (155)
Selective loss of T cell functions in different stages of HIV infection Early loss ofanti‐CD3‐induced T cell proliferation followed by decreased anti‐CD3‐induced cytotoxic T lymphocyte generation in AIDS‐related complex and AIDS (1990) (155)
Cytomegalovirus Infection Reduces Telomere Length of the Circulating T Cell Pool (2010) (153)
Expression of the activation antigen CD97 and its ligand CD55 in rheumatoid synovial tissue. (1999) (151)
CMV and Immunosenescence: from basics to clinics (2012) (147)
Aberrant expression and reverse signalling of CD70 on malignant B cells (1999) (146)
The Size and Phenotype of Virus-Specific T Cell Populations Is Determined by Repetitive Antigenic Stimulation and Environmental Cytokines 1 (2004) (139)
Expression and release of CD27 in human B-cell malignancies. (1993) (139)
CD27-CD70 interactions sensitise naive CD4+ T cells for IL-12-induced Th1 cell development. (2007) (136)
Heterogeneity of the circulating human CD4+ T cell population. Further evidence that the CD4+CD45RA-CD27- T cell subset contains specialized primed T cells. (1995) (135)
The costimulatory molecule CD27 maintains clonally diverse CD8(+) T cell responses of low antigen affinity to protect against viral variants. (2011) (134)
AIDS pathogenesis: a dynamic interaction between HIV and the immune system. (1990) (133)
Changes in the composition of circulating CD8+ T cell subsets during acute epstein-barr and human immunodeficiency virus infections in humans. (2000) (131)
GITR Triggering Induces Expansion of Both Effector and Regulatory CD4+ T Cells In Vivo1 (2009) (130)
CD30 expression does not discriminate between human Th1- and Th2-type T cells. (1996) (129)
A soluble form of the human T cell differentiation antigen CD27 is released after triggering of the TCR/CD3 complex. (1991) (128)
Human CD8+ T lymphocytes can be divided into CD45RA+ and CD45RO+ cells with different requirements for activation and differentiation. (1991) (127)
Signaling through CD70 Regulates B Cell Activation and IgG Production (2004) (127)
B Cells Are Crucial for Both Development and Maintenance of the Splenic Marginal Zone1 (2004) (125)
Characterization of the CD55 (DAF)‐binding site on the seven‐span transmembrane receptor CD97 (1998) (121)
IL-21 and CD40L signals from autologous T cells can induce antigen-independent proliferation of CLL cells. (2013) (118)
Regulation of expression of CD27, a T cell-specific member of a novel family of membrane receptors. (1991) (116)
CD70 represents the human ligand for CD27. (1994) (114)
Enhanced formation and survival of CD4+ CD25hi Foxp3+ T-cells in chronic lymphocytic leukemia (2009) (113)
CD5 is associated with the human B cell antigen receptor complex (1994) (112)
Strong selection of virus-specific cytotoxic CD4+ T-cell clones during primary human cytomegalovirus infection. (2006) (110)
Respiratory syncytial virus-specific CD8+ memory T cell responses in elderly persons. (2005) (105)
Deep Sequencing of Antiviral T-Cell Responses to HCMV and EBV in Humans Reveals a Stable Repertoire That Is Maintained for Many Years (2012) (105)
Properties of CD4(+) T cells in human cytomegalovirus infection. (2004) (104)
IL-21 Sustains CD28 Expression on IL-15-Activated Human Naive CD8+ T Cells (2005) (104)
Idiopathic CD4+ T lymphopenia without autoimmunity or granulomatous disease in the slipstream of RAG mutations. (2011) (102)
Tissue distribution of the human CD97 EGF-TM7 receptor. (2001) (101)
The CD27 membrane receptor, a lymphocyte‐specific member of the nerve growth factor receptor family, gives rise to a soluble form by protein processing that does not involve receptor endocytosis (1992) (99)
CD28 induces cell cycle progression by IL‐2‐independent down‐regulation of p27kip1 expression in human peripheral T lymphocytes (1999) (98)
Human T-cell memory consists mainly of unexpanded clones. (2010) (98)
Treatment with depleting CD4 monoclonal antibody results in a preferential loss of circulating naive T cells but does not affect IFN-gamma secreting TH1 cells in humans. (1997) (98)
Expression of the largest CD97 and EMR2 isoforms on leukocytes facilitates a specific interaction with chondroitin sulfate on B cells (2005) (97)
Characterization of murine CD70, the ligand of the TNF receptor family member CD27. (1997) (97)
Clonal analysis of functionally distinct human CD4+ T cell subsets (1988) (97)
The Epidermal Growth Factor-Seven Transmembrane (EGF-TM7) Receptor CD97 Is Required for Neutrophil Migration and Host Defense1 (2004) (93)
Increased expression of CD80, CD86 and CD70 on T cells from HIV‐infected individuals upon activation in vitro: regulation by CD4+ T cells (1996) (93)
Apoptosis threshold set by Noxa and Mcl-1 after T cell activation regulates competitive selection of high-affinity clones. (2010) (92)
The CR2/CD19 complex on human B cells contains the src-family kinase Lyn. (1993) (91)
TRM maintenance is regulated by tissue damage via P2RX7 (2018) (91)
Activated T cells can induce high levels of CTLA-4 expression on B cells. (1995) (89)
A dual role for both CD40-ligand and TNF-alpha in controlling human B cell death. (1996) (89)
Treatment with monoclonal anti-tumor necrosis factor alpha antibody results in an accumulation of Th1 CD4+ T cells in the peripheral blood of patients with rheumatoid arthritis. (1999) (89)
Cytomegalovirus-Induced Effector T Cells Cause Endothelial Cell Damage (2012) (88)
Induction of T cell proliferation with anti‐CD3 switch‐variant monoclonal antibodies: effects of heavy chain isotype in monocyte‐dependent systems (1987) (88)
Divergent SARS‐CoV‐2‐specific T‐ and B‐cell responses in severe but not mild COVID‐19 patients (2020) (88)
Immunological and virological markers in individuals progressing from seroconversion to AIDS. (1991) (85)
Antigen receptor nonresponsiveness in chronic lymphocytic leukemia B cells. (1995) (84)
Development of virus-specific CD4+ T cells on reexposure to Varicella-Zoster virus. (2004) (84)
Differential Regulation of Human IL-7 Receptor α Expression by IL-7 and TCR Signaling1 (2008) (82)
Proteomic Analyses of Human Regulatory T Cells Reveal Adaptations in Signaling Pathways that Protect Cellular Identity (2018) (82)
Functional studies with anti-CD3 heavy chain isotype switch-variant monoclonal antibodies. Accessory cell-independent induction of interleukin 2 responsiveness in T cells by epsilon-anti-CD3. (1987) (80)
Phenotype and function of human B cells expressing CD70 (CD27 ligand) (1996) (79)
Tissue-resident memory CD8+ T cells shape local and systemic secondary T cell responses (2020) (79)
Decreased accessory cell function by human monocytic cells after infection with HIV. (1988) (79)
Changes in cytokine secretion patterns of CD4+ T-cell clones in human immunodeficiency virus infection. (1994) (79)
Dual antigen recognition by B cells. (1993) (78)
Molecular cloning and characterization of mouse CD97. (2000) (78)
The human EGF‐TM7 family member EMR2 is a heterodimeric receptor expressed on myeloid cells (2002) (77)
Functional maturation of human naive T helper cells in the absence of accessory cells. Generation of IL-4-producing T helper cells does not require exogenous IL-4. (1995) (77)
Human virus-specific effector-type T cells accumulate in blood but not in lymph nodes. (2012) (76)
Antigen‐presenting cell‐derived signals determine expression levels of CD70 on‘qc primed T cells (1997) (74)
Hematopoietic Cell Phosphatase Is Recruited to CD22 following B Cell Antigen Receptor Ligation (*) (1995) (73)
Analysis of CD97 Expression and Manipulation: Antibody Treatment but Not Gene Targeting Curtails Granulocyte Migration1 (2008) (72)
Functional Heterogeneity of CD4+ Tumor-Infiltrating Lymphocytes With a Resident Memory Phenotype in NSCLC (2018) (72)
Properties of murine CD8+CD27– T cells (2005) (72)
Immobilized anti-CD3 monoclonal antibodies induce accessory cell-independent lymphokine production, proliferation and helper activity in human T lymphocytes. (1989) (71)
Immune responsiveness in renal transplant recipients: mycophenolic acid severely depresses humoral immunity in vivo. (2002) (70)
The Adhesion G Protein-Coupled Receptor GPR56/ADGRG1 Is an Inhibitory Receptor on Human NK Cells. (2016) (68)
CD27-CD70 Costimulation Controls T Cell Immunity during Acute and Persistent Cytomegalovirus Infection (2013) (68)
Memory CD4(+)CCR5(+) T cells are abundantly present in the gut of newborn infants to facilitate mother-to-child transmission of HIV-1. (2012) (68)
Expression of the activation antigen CD27 in rheumatoid arthritis. (1996) (68)
Elevation of cerebrospinal fluid soluble CD27 levels in patients with meningeal localization of lymphoid malignancies. (1996) (66)
Low SARS-CoV-2 seroprevalence in blood donors in the early COVID-19 epidemic in the Netherlands (2020) (66)
Quantitation of interferon gamma- and interleukin-4-producing T cells in synovial fluid and peripheral blood of arthritis patients. (1999) (66)
B and T Lymphocyte Attenuator Is Highly Expressed on CMV-Specific T Cells during Infection and Regulates Their Function (2010) (64)
Soluble and cellular markers of T cell activation in patients with pulmonary sarcoidosis. (1993) (63)
Absence of circulating natural killer and primed CD8+ cells in life-threatening varicella. (2005) (63)
Shear Stress–Dependent Downregulation of the Adhesion-G Protein–Coupled Receptor CD97 on Circulating Leukocytes upon Contact with Its Ligand CD55 (2013) (61)
The membrane IgM-associated heterodimer on human B cells is a newly defined B cell antigen that contains the protein product of the mb-1 gene. (1991) (61)
Interferon (IFN)-beta treatment enhances CD95 and interleukin 10 expression but reduces interferon-gamma producing T cells in MS patients. (1999) (61)
AICL: a new activation-induced antigen encoded by the human NK gene complex (1997) (60)
Regulatory role of CD19 molecules in B-cell activation and differentiation. (1989) (60)
Differential Usage of Cellular Niches by Cytomegalovirus versus EBV- and Influenza Virus-Specific CD8+ T Cells (2006) (60)
Blimp-1 Rather Than Hobit Drives the Formation of Tissue-Resident Memory CD8+ T Cells in the Lungs (2019) (59)
Functional B cell abnormalities in HIV type 1 infection: role of CD40L and CD70. (1997) (59)
Elevated levels of T cell activation antigen CD27 and increased interleukin‐4 production in human lymphatic filariasis (1993) (59)
Soluble interleukin-2 receptor (sIL-2R) is a marker of disease activity in psoriasis: a comparison of sIL-2R, sCD27, sCD4, sCD8 and sICAM-1. (1996) (59)
The B29 and mb‐1 polypeptides are differentially expressed during human B cell differentiation (1992) (59)
CROSS-REACTIVITY OF CYTOMEGALOVIRUS-SPECIFIC CD8+ T CELLS TO ALLO-MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I MOLECULES (2004) (58)
The role of lymphocyte subsets and adhesion molecules in T cell‐dependent cytotoxicity mediated by CD3 and CD28 bispecific monoclonal antibodies (1995) (57)
The structure of the μ/pseudo light chain complex on human pre‐B cells is consistent with a function in signal transduction (1993) (57)
Increased numbers of in vivo activated T cells in patients with recent onset insulin-dependent diabetes mellitus. (1996) (55)
Dissection of pathways leading to antigen receptor-induced and Fas/CD95-induced apoptosis in human B cells. (1998) (55)
Inactivation of the EGF‐TM7 receptor EMR4 after the Pan‐Homo divergence (2003) (54)
CMV-specific CD8+ T-cell function is not impaired in chronic lymphocytic leukemia. (2014) (54)
Protective CD8 T Cell Memory Is Impaired during Chronic CD70-Driven Costimulation1 (2009) (54)
Intracellular cytokine profile in T-cell subsets of multiple sclerosis patients: different features in primary progressive disease (2001) (54)
Everolimus-Treated Renal Transplant Recipients Have a More Robust CMV-Specific CD8+ T-Cell Response Compared With Cyclosporine- or Mycophenolate-Treated Patients (2013) (54)
CD97 neutralisation increases resistance to collagen-induced arthritis in mice (2006) (53)
Differential effect of transforming growth factor-beta 1 on the activation of human naive and memory CD4+ T lymphocytes. (1994) (52)
Cutting Edge: Virus Selectively Primes Human Langerhans Cells for CD70 Expression Promoting CD8+ T Cell Responses (2011) (51)
Comparison of human B cell antigen receptor complexes: membrane- expressed forms of immunoglobulin (Ig)M, IgD, and IgG are associated with structurally related heterodimers (1992) (51)
Rapamycin Does Not Induce Anergy but Inhibits Expansion and Differentiation of Alloreactive Human T Cells (2006) (50)
Blimp‐1 induces and Hobit maintains the cytotoxic mediator granzyme B in CD8 T cells (2018) (50)
The Transcription Factor Hobit Identifies Human Cytotoxic CD4+ T Cells (2017) (49)
Infection History Determines the Differentiation State of Human CD8+ T Cells (2015) (49)
Common gamma chain cytokines: dissidence in the details. (2007) (48)
Alloantigen-induced regulatory CD8+CD103+ T cells. (2008) (48)
Non‐mitogenic T cell activation signals are sufficient for induction of human immunodeficiency virus transcription (1991) (48)
Human Cytomegalovirus Infection Induces a Rapid and Sustained Change in the Expression of NK Cell Receptors on CD8+ T Cells1 (2008) (47)
Kawasaki disease: a maturational defect in immune responsiveness. (1999) (47)
Structure of the human CD97 gene: exon shuffling has generated a new type of seven-span transmembrane molecule related to the secretin receptor superfamily. (1996) (46)
The Contribution of Cytomegalovirus Infection to Immune Senescence Is Set by the Infectious Dose (2018) (46)
Recombinant interferon-beta blocks proliferation but enhances interleukin-10 secretion by activated human T-cells. (1996) (46)
Characterization of CD4+ memory T cell responses directed against common respiratory pathogens in peripheral blood and lung. (2007) (45)
Cellular immune responses during high-dose interferon-alpha induction therapy for hepatitis C virus infection. (2009) (45)
Report from the second cytomegalovirus and immunosenescence workshop (2011) (45)
Identification of a novel subpopulation of germinal center B cells characterized by expression of IgD and CD70 (1996) (44)
Bispecific antibody-mediated target cell-specific costimulation of resting T cells via CD5 and CD28. (1995) (44)
Seasonal variation in immune measurements and MRI markers of disease activity in MS (2002) (42)
Graft-versus-host-like disease complicating thymoma: lack of AIRE expression as a cause of non-hereditary autoimmunity? (2007) (41)
Cytomegalovirus (CMV) research in immune senescence comes of age: overview of the 6th International Workshop on CMV and Immunosenescence (2017) (40)
A fingerprint left by cytomegalovirus infection in the human T cell compartment. (2008) (40)
Restoration of T cell function in chronic hepatitis B patients upon treatment with interferon based combination therapy. (2016) (40)
Cure of disseminated xenografted human Hodgkin's tumors by bispecific monoclonal antibodies and human T cells: the role of human T-cell subsets in a preclinical model. (1996) (39)
Effects of IL-4, IL-5, and IL-6 on growth and immunoglobulin production of Epstein-Barr virus-infected human B cells. (1992) (39)
Functional re-expression of CCR7 on CMV-specific CD8+ T cells upon antigenic stimulation. (2005) (39)
Children with chronic renal failure have reduced numbers of memory B cells (2004) (37)
Circulating lymphocyte subsets in different clinical situations after renal transplantation (2012) (37)
CD70 expression on T-cell subpopulations: study of normal individuals and patients with chronic immune activation. (1997) (36)
Cutting Edge: CD95 Maintains Effector T Cell Homeostasis in Chronic Immune Activation (2005) (36)
Alternative molecular form of human T cell‐specific antigen CD27 expressed upon T cell activation (1989) (35)
Analysis of stem-cell-like properties of human CD161++IL-18Rα+ memory CD8+ T cells. (2012) (34)
Regulatory properties of LFA-1 alpha and beta chains in human T-lymphocyte activation. (1988) (34)
Human virus‐specific CD8+ T cells: diversity specialists (2006) (33)
CD30‐antigen‐specific targeting and activation of T cells via murine bispecific monoclonal antibodies against CD3 and CD28: Potential use for the treatment of hodgkin's lymphoma (1993) (33)
BH3-only protein Noxa regulates apoptosis in activated B cells and controls high-affinity antibody formation. (2012) (33)
Type I IFNs differentially modulate IL-12p70 production by human dendritic cells depending on the maturation status of the cells and counteract IFN-gamma-mediated signaling. (2003) (33)
Rapamycin Enhances the Number of Alloantigen-Induced Human CD103+CD8+ Regulatory T Cells In Vitro (2007) (33)
A reversion of an IL2RG mutation in combined immunodeficiency providing competitive advantage to the majority of CD8+ T cells (2013) (33)
Mechanism of inhibition and induction of cytolytic activity in cytotoxic T lymphocytes by CD3 monoclonal antibodies. (1987) (33)
Expansion of effector T cells associated with decreased PD-1 expression in patients with indolent B cell lymphomas and chronic lymphocytic leukemia (2012) (32)
Phenotypic and Functional Characterization of Circulating Polyomavirus BK VP1-Specific CD8+ T Cells in Healthy Adults (2013) (31)
Hobit identifies tissue-resident memory T cell precursors that are regulated by Eomes (2021) (30)
Influence of CD28 co-stimulation on cytokine production is mainly regulated via interleukin-2. (1994) (29)
Differential sensitivity of human naive and memory CD4+ T cells for dexamethasone. (1995) (29)
Continuous CD27 triggering in vivo strongly reduces NK cell numbers (2010) (29)
Anti-CD3 murine monoclonal isotype switch variants tested for toxicity and immunologic monitoring in four chimpanzees. (1990) (29)
Clonal Evolution of CD8+ T Cell Responses against Latent Viruses: Relationship among Phenotype, Localization, and Function (2014) (28)
Pro-Apoptotic Protein Noxa Regulates Memory T Cell Population Size and Protects against Lethal Immunopathology (2013) (28)
T cell subpopulation phenotypes in filarial infections: CD27 negativity defines a population greatly enriched for Th2 cells. (1994) (27)
Regulation of T-cell differentiation by CD2 and CD28 accessory molecules. (1991) (27)
Monitoring the T-Cell Receptor Repertoire at Single-Clone Resolution (2006) (27)
Tolerance to factor VIII in a transgenic mouse expressing human factor VIII cDNA carrying an Arg593 to Cys substitution (2006) (27)
Maturation- and differentiation-dependent responsiveness of human CD4+ T helper subsets. (1992) (27)
Label-free Analysis of CD8+ T Cell Subset Proteomes Supports a Progressive Differentiation Model of Human-Virus-Specific T Cells. (2017) (26)
A New Subset of Human Naive CD8+ T Cells Defined by Low Expression of IL-7Rα1 (2007) (25)
TNFα production by CD4+ T cells predicts long-term increase in lesion load on MRI in MS (2001) (24)
Generation of alloreactive cytolytic T lymphocytes by immobilized anti-CD3 monoclonal antibodies. Analysis of requirements for human cytolytic T-lymphocyte differentiation. (1990) (24)
Divergent SARS-CoV-2-specific T and B cell responses in severe but not mild COVID-19 (2020) (24)
Withdrawal symptoms on display: Bcl-2 members under investigation. (2007) (24)
Chronic CD70-Driven Costimulation Impairs IgG Responses by Instructing T Cells to Inhibit Germinal Center B Cell Formation through FasL-Fas Interactions1 (2009) (24)
CD70-Driven Chronic Immune Activation Is Protective against Atherosclerosis (2010) (24)
Differentiation of Human Alloreactive CD4+ and CD8+ T Cells In Vitro (2004) (23)
Enhanced CD8 T Cell Responses through GITR-Mediated Costimulation Resolve Chronic Viral Infection (2015) (23)
Expression of IL‐7Rα and KLRG1 defines functionally distinct CD8+ T‐cell populations in humans (2019) (22)
CXCR5+CD4+ follicular helper T cells accumulate in resting human lymph nodes and have superior B cell helper activity. (2014) (22)
Simultaneous regulation of CD2 adhesion and signaling functions by a novel CD2 monoclonal antibody. (1994) (22)
CD27-CD70 interaction: unravelling its implication in normal and neoplastic B-cell growth. (1995) (22)
CD70-Driven Costimulation Induces Survival or Fas-Mediated Apoptosis of T Cells Depending on Antigenic Load (2012) (22)
Rapid T cell repopulation after rabbit anti‐thymocyte globulin (rATG) treatment is driven mainly by cytomegalovirus (2012) (22)
Architecture of the human B-cell antigen receptors. (1993) (20)
A Novel Role for CD55 in Granulocyte Homeostasis and Anti-Bacterial Host Defense (2011) (20)
Cutting Edge: Distinct NK Receptor Profiles Are Imprinted on CD8 T Cells in the Mucosa and Periphery during the Same Antigen Challenge: Role of Tissue-Specific Factors1 (2007) (20)
Viral double-stranded RNA sensors induce antiviral, pro-inflammatory, and pro-apoptotic responses in human renal tubular epithelial cells. (2012) (20)
Analysis of the role of leukocyte function-associated antigen-1 in activation of human influenza virus-specific T cell clones. (1990) (18)
Cutting Edge: Distinct NK receptor profiles are imprinted on CD8 T cells in the mucosa and periphery during the same antigen challenge: role of tissue-specific factors. (2007) (17)
Induction and maintenance of CD8+ T cells specific for persistent viruses. (2007) (16)
Serum levels of soluble CD27 in renal transplant recipients. (1992) (16)
Aberrant humoral immune reactivity in DOCK8 deficiency with follicular hyperplasia and nodal plasmacytosis. (2013) (16)
Two monoclonal anti‐CD3 antibodies can induce different events in human T lymphocyte activation (1987) (16)
Alteration of B-cell Antigen Receptor Signaling by CD19 Co-ligation. (1996) (16)
Function of CD27 in helper T cell differentiation. (2011) (15)
Heterogeneity in both cytokine production and responsiveness of a panel of monoclonal human Epstein-Barr virus-transformed B-cell lines. (1991) (14)
Antigen receptor function in chronic lymphocytic leukemia B cells. (1996) (14)
Clinically Relevant Reactivation of Polyomavirus BK (BKPyV) in HLA-A02-Positive Renal Transplant Recipients Is Associated with Impaired Effector-Memory Differentiation of BKPyV-Specific CD8+ T Cells (2016) (14)
Comparison of the response to T-cell activation by integrated HIV-1 and HTLV-1 LTR-lacZ vectors. (1995) (14)
Studies on the monocyte dependence of T-cell proliferation induced by monoclonal antibodies directed against regions I and II of the CD2 antigen. (1989) (13)
Sevenspan transmembrane molecules: novel receptors involved in leukocyte adhesion. (1996) (13)
Persistent Detection of Varicella-Zoster Virus DNA in a Previously Healthy Child after Severe Chickenpox (2005) (13)
Evidence for a direct physical interaction of membrane IgM, IgD, and IgG with the B29 gene product. (1994) (12)
CD4(+) T-cell dynamics in primary cytomegalovirus infection. (2001) (11)
A novel mutation in CD132 causes X-CID with defective T-cell activation and impaired humoral reactivity. (2011) (10)
Characterization of a human plasmacytoma line (1991) (10)
The price of the CD27–CD70 costimulatory axis: you can't have it all (2006) (9)
CD8 and CD4 T Cell Populations in Human Kidneys (2021) (9)
Cytotoxic human CD4(+) T cells. (2008) (9)
Erratum: Programs for the persistence, vigilance and control of human CD8+ lung-resident memory T cells (2017) (8)
Characteristics of alloreactive T cells measured before renal transplantation (2012) (8)
Assessing the replicative history of human T cells. (1999) (8)
CD28 and T-cell activation. (1995) (7)
Common variable immunodeficiency and hemophagocytic features associated with a FAS gene mutation. (2011) (7)
A combined immunodeficiency with oligoclonal CD8+, V beta 3-expressing, cytotoxic T lymphocytes in the peripheral blood. (1992) (7)
Single-Cell Transcriptomics Reveals Discrete Steps in Regulatory T Cell Development in the Human Thymus. (2021) (6)
Interferon‐gamma administration after abdominal surgery rescues antigen‐specific helper T cell immune reactivity (2001) (6)
CD27 contributes to the early systemic immune response to Mycobacterium tuberculosis infection but does not affect outcome. (2006) (6)
The effects of prednisolone and cyclosporin A on monocyte-dependent and -independent human T-cell proliferation in vitro. (1989) (5)
Defect of interleukin-2 production and T cell proliferation in atopic patients: restoring ability of the CD28-mediated activation pathway. (1993) (5)
Mitogenic activity of anti-CD28 MoAb CLB-CD28/1 on peripheral blood mononuclear cells and its cooperation with other anti-T cells MoAb in the activation of purified T lymphocytes. (1990) (5)
GITR shapes humoral immunity by controlling the balance between follicular T helper cells and regulatory T follicular cells. (2020) (5)
Tumor immunity requires border patrol to fight the enemy within (2017) (5)
Upregulation of CXCR3 expression on CD8+ T cells due to the pervasive influence of chronic hepatitis B and C virus infection. (2013) (5)
PGE2 and the immune response. A central role for prostaglandin E2 in downregulating the inflammatory immune response. (1995) (4)
The interaction between cytomegalovirus and the human immune system. (2014) (4)
CMV-specific CD8(pos) T lymphocyte differentiation in latent CMV infection. (2001) (4)
CD8(POS) lymphocyte dynamics in primary CMV infection. (2001) (4)
Hobit and Blimp‐1 regulate TRM abundance after LCMV infection by suppressing tissue exit pathways of TRMprecursors (2022) (4)
Adequate synapse formation between leukemic B cells and effector T cells following stimulation with artificial TCR ligands (2008) (3)
Non FcR‐binding murine antihuman CD3 monoclonal antibody is capable of productive TCR signalling and induces proliferation in the presence of costimulation (2001) (3)
Compartmentalization of B-cell antigen receptor functions. (1996) (3)
Differentiation of CMV-specific CD8(POS) T lymphocytes in primary CMV infection after renal transplantation. (2001) (3)
Conformational changes in CD45 upon monoclonal antibody crosslinking. (1996) (3)
Detection of allospecific T cells by intracellular cytokine staining and flowcytometry. (2001) (3)
Constitutive co-stimulation by B cells is sufficient to trigger T cell-driven autoimmune disease (2010) (2)
The cellular immune system comes of age. (2017) (2)
Lymphocyte costimulation: multiple pathways, multiple functions? (1995) (2)
Polyfunctional pathogen-specific CD4+ T cells reside in the lungs and tumors of NSCLC patients (2022) (1)
Clinical consequences of primary CMV infection after renal transplantation: a case–control study (2020) (1)
Surface expression of immunoglobulin isotypes on primary human B cells: no evidence for glycosyl-phosphatidylinositol linkage. (1993) (1)
Protein kinase C regulates secretion of lymphotoxin (LT/TNF beta) and TNF alpha by human EBV-transformed B cells. (1992) (1)
How to Reliably Define Human CD8+ T-Cell Subsets: Markers Playing Tricks. (2021) (1)
The bug in MyD88 dependency. (2006) (1)
Regulation of NF-kappa B nuclear activity in peripheral blood mononuclear cells: role of CD28 antigen. (1994) (1)
Hobit and Blimp‐1 instruct the differentiation of iNKT cells into resident‐phenotype lymphocytes after lineage commitment (2021) (1)
Immune checkpoint blockade: Which switches to hit and how much? (2016) (1)
Expression of the IL-6 gene induces differentiation of a human monoclonal EBV-transformed B cell line. (1993) (0)
Allo-reactive tissue-resident T cells causing damage: An inside job (2022) (0)
The pyrimidin analogue cyclopentenyl cytosine induces alloantigen‐specific non‐responsiveness of human T lymphocytes (2008) (0)
CMV and Immunosenescence: from basics to clinics (2012) (0)
Response to Comment on “Differential Usage of Cellular Niches by Cytomegalovirus versus EBV- and Influenza Virus-Specific CD8+ T Cells” (2007) (0)
Tissue-resident memory T cells populate the human brain (2018) (0)
EFIS - Building an European Immunology Community. (2017) (0)
[Signals for cellular selection for life and death by a new family of cytokines]. (1996) (0)
Tissue-resident memory T cells at the center of immunity to solid tumors (2018) (0)
[Soluble T-cell-membrane molecules; a measure for in-vivo T-cell activation]. (1992) (0)
Dutch immunology: vibrant throughout the years. (2012) (0)
Cytomegalovirus (CMV) research in immune senescence comes of age: overview of the 6th International Workshop on CMV and Immunosenescence (2017) (0)
News and EFIS (2012) (0)
Effect of IL-6 on proliferation and IG production of human EBV-transformed cell lines in serum free culture media. (1990) (0)

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What Schools Are Affiliated With René a. w. Van Lier?

René a. w. Van Lier is affiliated with the following schools:

University of Amsterdam