René a. w. Van Lier
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Biology
René a. w. Van Lier's Degrees
- PhD Immunology University of Amsterdam
- Masters Biomedical Sciences University of Amsterdam
- Bachelors Biomedical Sciences University of Amsterdam
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(Suggest an Edit or Addition)René a. w. Van Lier's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Phenotypic and Functional Separation of Memory and Effector Human CD8+ T Cells (1997) (1513)
- Phenotype and function of human T lymphocyte subsets: Consensus and issues (2008) (747)
- Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes (2016) (642)
- Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition) (2019) (627)
- Primary immune responses to human CMV: a critical role for IFN-gamma-producing CD4+ T cells in protection against CMV disease. (2003) (462)
- The seven-span transmembrane receptor CD97 has a cellular ligand (CD55, DAF) (1996) (372)
- Emergence of a CD4+CD28− Granzyme B+, Cytomegalovirus-Specific T Cell Subset after Recovery of Primary Cytomegalovirus Infection (2004) (359)
- CD20 deficiency in humans results in impaired T cell-independent antibody responses. (2010) (351)
- Programs for the persistence, vigilance and control of human CD8+ lung-resident memory T cells (2016) (316)
- Constitutive CD27/CD70 interaction induces expansion of effector-type T cells and results in IFNgamma-mediated B cell depletion. (2001) (305)
- Timing and tuning of CD27–CD70 interactions: the impact of signal strength in setting the balance between adaptive responses and immunopathology (2009) (291)
- Human atopen-specific types 1 and 2 T helper cell clones. (1991) (286)
- Regulation of CD27 expression on subsets of mature T-lymphocytes. (1993) (282)
- Differentiation of cytomegalovirus-specific CD8(+) T cells in healthy and immunosuppressed virus carriers. (2001) (258)
- Engagement of CD27 with its ligand CD70 provides a second signal for T cell activation. (1995) (247)
- Tissue distribution and biochemical and functional properties of Tp55 (CD27), a novel T cell differentiation antigen. (1987) (243)
- Expression of the Murine CD27 Ligand CD70 In Vitro and In Vivo4 (2003) (238)
- Control of lymphocyte function through CD27-CD70 interactions. (1998) (236)
- Reconstitution of the T-cell compartment after bone marrow transplantation: restoration of the repertoire by thymic emigrants. (1998) (228)
- Leukocyte adhesion deficiency type 1 (LAD-1)/variant. A novel immunodeficiency syndrome characterized by dysfunctional beta2 integrins. (1997) (224)
- Evidence that human CD8+CD45RA+CD27- cells are induced by antigen and evolve through extensive rounds of division. (1999) (218)
- Faces and phases of human CD8 T-cell development. (1999) (207)
- Functional and phenotypic evidence for a selective loss of memory T cells in asymptomatic human immunodeficiency virus-infected men. (1990) (204)
- Selective accumulation of differentiated CD8+ T cells specific for respiratory viruses in the human lung (2005) (204)
- Development of virus-specific CD4(+) T cells during primary cytomegalovirus infection. (2000) (203)
- Tissue-resident memory T cells populate the human brain (2018) (198)
- The Noxa/Mcl-1 axis regulates susceptibility to apoptosis under glucose limitation in dividing T cells. (2006) (198)
- Neutrophils Kill Antibody-Opsonized Cancer Cells by Trogoptosis. (2018) (189)
- Characterization of the human CD27 ligand, a novel member of the TNF gene family. (1994) (188)
- IL-7 receptor alpha chain expression distinguishes functional subsets of virus-specific human CD8+ T cells. (2005) (188)
- Tumor Rejection Induced by CD70-mediated Quantitative and Qualitative Effects on Effector CD8+ T Cell Formation (2004) (185)
- The CD27− subset of peripheral blood memory CD4+ lymphocytes contains functionally differentiated T lymphocytes that develop by persistent antigenic stimulation in vivo (1992) (184)
- Clinical and Immunologic Aspects of Cytomegalovirus Infection in Solid Organ Transplant Recipients (2005) (181)
- Cure of xenografted human tumors by bispecific monoclonal antibodies and human T cells. (1994) (180)
- Frequencies of Circulating Cytolytic, CD45RA+CD27−, CD8+ T Lymphocytes Depend on Infection with CMV1 (2003) (180)
- Expression cloning and chromosomal mapping of the leukocyte activation antigen CD97, a new seven-span transmembrane molecule of the secretion receptor superfamily with an unusual extracellular domain. (1995) (179)
- Molecular profiling of cytomegalovirus-induced human CD8+ T cell differentiation. (2010) (177)
- Tissue-resident memory T cells at the center of immunity to solid tumors (2018) (176)
- CD27 Defines Phenotypically and Functionally Different Human NK Cell Subsets (2008) (175)
- Proliferation Requirements of Cytomegalovirus-Specific, Effector-Type Human CD8+ T Cells1 (2002) (175)
- IL-15 induces antigen-independent expansion and differentiation of human naive CD8+ T cells in vitro. (2003) (172)
- CD27: marker and mediator of T-cell activation? (1994) (169)
- CD103 Is a Marker for Alloantigen-Induced Regulatory CD8+ T Cells (2006) (168)
- Defective TCR-mediated signaling in synovial T cells in rheumatoid arthritis. (1997) (164)
- Human cytomegalovirus induces systemic immune activation characterized by a type 1 cytokine signature. (2010) (155)
- CD8⁺ T cells with an intraepithelial phenotype upregulate cytotoxic function upon influenza infection in human lung. (2011) (155)
- Selective loss of T cell functions in different stages of HIV infection Early loss ofanti‐CD3‐induced T cell proliferation followed by decreased anti‐CD3‐induced cytotoxic T lymphocyte generation in AIDS‐related complex and AIDS (1990) (155)
- Cytomegalovirus Infection Reduces Telomere Length of the Circulating T Cell Pool (2010) (153)
- Expression of the activation antigen CD97 and its ligand CD55 in rheumatoid synovial tissue. (1999) (151)
- CMV and Immunosenescence: from basics to clinics (2012) (147)
- Aberrant expression and reverse signalling of CD70 on malignant B cells (1999) (146)
- The Size and Phenotype of Virus-Specific T Cell Populations Is Determined by Repetitive Antigenic Stimulation and Environmental Cytokines 1 (2004) (139)
- Expression and release of CD27 in human B-cell malignancies. (1993) (139)
- CD27-CD70 interactions sensitise naive CD4+ T cells for IL-12-induced Th1 cell development. (2007) (136)
- Heterogeneity of the circulating human CD4+ T cell population. Further evidence that the CD4+CD45RA-CD27- T cell subset contains specialized primed T cells. (1995) (135)
- The costimulatory molecule CD27 maintains clonally diverse CD8(+) T cell responses of low antigen affinity to protect against viral variants. (2011) (134)
- AIDS pathogenesis: a dynamic interaction between HIV and the immune system. (1990) (133)
- Changes in the composition of circulating CD8+ T cell subsets during acute epstein-barr and human immunodeficiency virus infections in humans. (2000) (131)
- GITR Triggering Induces Expansion of Both Effector and Regulatory CD4+ T Cells In Vivo1 (2009) (130)
- CD30 expression does not discriminate between human Th1- and Th2-type T cells. (1996) (129)
- A soluble form of the human T cell differentiation antigen CD27 is released after triggering of the TCR/CD3 complex. (1991) (128)
- Human CD8+ T lymphocytes can be divided into CD45RA+ and CD45RO+ cells with different requirements for activation and differentiation. (1991) (127)
- Signaling through CD70 Regulates B Cell Activation and IgG Production (2004) (127)
- B Cells Are Crucial for Both Development and Maintenance of the Splenic Marginal Zone1 (2004) (125)
- Characterization of the CD55 (DAF)‐binding site on the seven‐span transmembrane receptor CD97 (1998) (121)
- IL-21 and CD40L signals from autologous T cells can induce antigen-independent proliferation of CLL cells. (2013) (118)
- Regulation of expression of CD27, a T cell-specific member of a novel family of membrane receptors. (1991) (116)
- CD70 represents the human ligand for CD27. (1994) (114)
- Enhanced formation and survival of CD4+ CD25hi Foxp3+ T-cells in chronic lymphocytic leukemia (2009) (113)
- CD5 is associated with the human B cell antigen receptor complex (1994) (112)
- Strong selection of virus-specific cytotoxic CD4+ T-cell clones during primary human cytomegalovirus infection. (2006) (110)
- Respiratory syncytial virus-specific CD8+ memory T cell responses in elderly persons. (2005) (105)
- Deep Sequencing of Antiviral T-Cell Responses to HCMV and EBV in Humans Reveals a Stable Repertoire That Is Maintained for Many Years (2012) (105)
- Properties of CD4(+) T cells in human cytomegalovirus infection. (2004) (104)
- IL-21 Sustains CD28 Expression on IL-15-Activated Human Naive CD8+ T Cells (2005) (104)
- Idiopathic CD4+ T lymphopenia without autoimmunity or granulomatous disease in the slipstream of RAG mutations. (2011) (102)
- Tissue distribution of the human CD97 EGF-TM7 receptor. (2001) (101)
- The CD27 membrane receptor, a lymphocyte‐specific member of the nerve growth factor receptor family, gives rise to a soluble form by protein processing that does not involve receptor endocytosis (1992) (99)
- CD28 induces cell cycle progression by IL‐2‐independent down‐regulation of p27kip1 expression in human peripheral T lymphocytes (1999) (98)
- Human T-cell memory consists mainly of unexpanded clones. (2010) (98)
- Treatment with depleting CD4 monoclonal antibody results in a preferential loss of circulating naive T cells but does not affect IFN-gamma secreting TH1 cells in humans. (1997) (98)
- Expression of the largest CD97 and EMR2 isoforms on leukocytes facilitates a specific interaction with chondroitin sulfate on B cells (2005) (97)
- Characterization of murine CD70, the ligand of the TNF receptor family member CD27. (1997) (97)
- Clonal analysis of functionally distinct human CD4+ T cell subsets (1988) (97)
- The Epidermal Growth Factor-Seven Transmembrane (EGF-TM7) Receptor CD97 Is Required for Neutrophil Migration and Host Defense1 (2004) (93)
- Increased expression of CD80, CD86 and CD70 on T cells from HIV‐infected individuals upon activation in vitro: regulation by CD4+ T cells (1996) (93)
- Apoptosis threshold set by Noxa and Mcl-1 after T cell activation regulates competitive selection of high-affinity clones. (2010) (92)
- The CR2/CD19 complex on human B cells contains the src-family kinase Lyn. (1993) (91)
- TRM maintenance is regulated by tissue damage via P2RX7 (2018) (91)
- Activated T cells can induce high levels of CTLA-4 expression on B cells. (1995) (89)
- A dual role for both CD40-ligand and TNF-alpha in controlling human B cell death. (1996) (89)
- Treatment with monoclonal anti-tumor necrosis factor alpha antibody results in an accumulation of Th1 CD4+ T cells in the peripheral blood of patients with rheumatoid arthritis. (1999) (89)
- Cytomegalovirus-Induced Effector T Cells Cause Endothelial Cell Damage (2012) (88)
- Induction of T cell proliferation with anti‐CD3 switch‐variant monoclonal antibodies: effects of heavy chain isotype in monocyte‐dependent systems (1987) (88)
- Divergent SARS‐CoV‐2‐specific T‐ and B‐cell responses in severe but not mild COVID‐19 patients (2020) (88)
- Immunological and virological markers in individuals progressing from seroconversion to AIDS. (1991) (85)
- Antigen receptor nonresponsiveness in chronic lymphocytic leukemia B cells. (1995) (84)
- Development of virus-specific CD4+ T cells on reexposure to Varicella-Zoster virus. (2004) (84)
- Differential Regulation of Human IL-7 Receptor α Expression by IL-7 and TCR Signaling1 (2008) (82)
- Proteomic Analyses of Human Regulatory T Cells Reveal Adaptations in Signaling Pathways that Protect Cellular Identity (2018) (82)
- Functional studies with anti-CD3 heavy chain isotype switch-variant monoclonal antibodies. Accessory cell-independent induction of interleukin 2 responsiveness in T cells by epsilon-anti-CD3. (1987) (80)
- Phenotype and function of human B cells expressing CD70 (CD27 ligand) (1996) (79)
- Tissue-resident memory CD8+ T cells shape local and systemic secondary T cell responses (2020) (79)
- Decreased accessory cell function by human monocytic cells after infection with HIV. (1988) (79)
- Changes in cytokine secretion patterns of CD4+ T-cell clones in human immunodeficiency virus infection. (1994) (79)
- Dual antigen recognition by B cells. (1993) (78)
- Molecular cloning and characterization of mouse CD97. (2000) (78)
- The human EGF‐TM7 family member EMR2 is a heterodimeric receptor expressed on myeloid cells (2002) (77)
- Functional maturation of human naive T helper cells in the absence of accessory cells. Generation of IL-4-producing T helper cells does not require exogenous IL-4. (1995) (77)
- Human virus-specific effector-type T cells accumulate in blood but not in lymph nodes. (2012) (76)
- Antigen‐presenting cell‐derived signals determine expression levels of CD70 on‘qc primed T cells (1997) (74)
- Hematopoietic Cell Phosphatase Is Recruited to CD22 following B Cell Antigen Receptor Ligation (*) (1995) (73)
- Analysis of CD97 Expression and Manipulation: Antibody Treatment but Not Gene Targeting Curtails Granulocyte Migration1 (2008) (72)
- Functional Heterogeneity of CD4+ Tumor-Infiltrating Lymphocytes With a Resident Memory Phenotype in NSCLC (2018) (72)
- Properties of murine CD8+CD27– T cells (2005) (72)
- Immobilized anti-CD3 monoclonal antibodies induce accessory cell-independent lymphokine production, proliferation and helper activity in human T lymphocytes. (1989) (71)
- Immune responsiveness in renal transplant recipients: mycophenolic acid severely depresses humoral immunity in vivo. (2002) (70)
- The Adhesion G Protein-Coupled Receptor GPR56/ADGRG1 Is an Inhibitory Receptor on Human NK Cells. (2016) (68)
- CD27-CD70 Costimulation Controls T Cell Immunity during Acute and Persistent Cytomegalovirus Infection (2013) (68)
- Memory CD4(+)CCR5(+) T cells are abundantly present in the gut of newborn infants to facilitate mother-to-child transmission of HIV-1. (2012) (68)
- Expression of the activation antigen CD27 in rheumatoid arthritis. (1996) (68)
- Elevation of cerebrospinal fluid soluble CD27 levels in patients with meningeal localization of lymphoid malignancies. (1996) (66)
- Low SARS-CoV-2 seroprevalence in blood donors in the early COVID-19 epidemic in the Netherlands (2020) (66)
- Quantitation of interferon gamma- and interleukin-4-producing T cells in synovial fluid and peripheral blood of arthritis patients. (1999) (66)
- B and T Lymphocyte Attenuator Is Highly Expressed on CMV-Specific T Cells during Infection and Regulates Their Function (2010) (64)
- Soluble and cellular markers of T cell activation in patients with pulmonary sarcoidosis. (1993) (63)
- Absence of circulating natural killer and primed CD8+ cells in life-threatening varicella. (2005) (63)
- Shear Stress–Dependent Downregulation of the Adhesion-G Protein–Coupled Receptor CD97 on Circulating Leukocytes upon Contact with Its Ligand CD55 (2013) (61)
- The membrane IgM-associated heterodimer on human B cells is a newly defined B cell antigen that contains the protein product of the mb-1 gene. (1991) (61)
- Interferon (IFN)-beta treatment enhances CD95 and interleukin 10 expression but reduces interferon-gamma producing T cells in MS patients. (1999) (61)
- AICL: a new activation-induced antigen encoded by the human NK gene complex (1997) (60)
- Regulatory role of CD19 molecules in B-cell activation and differentiation. (1989) (60)
- Differential Usage of Cellular Niches by Cytomegalovirus versus EBV- and Influenza Virus-Specific CD8+ T Cells (2006) (60)
- Blimp-1 Rather Than Hobit Drives the Formation of Tissue-Resident Memory CD8+ T Cells in the Lungs (2019) (59)
- Functional B cell abnormalities in HIV type 1 infection: role of CD40L and CD70. (1997) (59)
- Elevated levels of T cell activation antigen CD27 and increased interleukin‐4 production in human lymphatic filariasis (1993) (59)
- Soluble interleukin-2 receptor (sIL-2R) is a marker of disease activity in psoriasis: a comparison of sIL-2R, sCD27, sCD4, sCD8 and sICAM-1. (1996) (59)
- The B29 and mb‐1 polypeptides are differentially expressed during human B cell differentiation (1992) (59)
- CROSS-REACTIVITY OF CYTOMEGALOVIRUS-SPECIFIC CD8+ T CELLS TO ALLO-MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I MOLECULES (2004) (58)
- The role of lymphocyte subsets and adhesion molecules in T cell‐dependent cytotoxicity mediated by CD3 and CD28 bispecific monoclonal antibodies (1995) (57)
- The structure of the μ/pseudo light chain complex on human pre‐B cells is consistent with a function in signal transduction (1993) (57)
- Increased numbers of in vivo activated T cells in patients with recent onset insulin-dependent diabetes mellitus. (1996) (55)
- Dissection of pathways leading to antigen receptor-induced and Fas/CD95-induced apoptosis in human B cells. (1998) (55)
- Inactivation of the EGF‐TM7 receptor EMR4 after the Pan‐Homo divergence (2003) (54)
- CMV-specific CD8+ T-cell function is not impaired in chronic lymphocytic leukemia. (2014) (54)
- Protective CD8 T Cell Memory Is Impaired during Chronic CD70-Driven Costimulation1 (2009) (54)
- Intracellular cytokine profile in T-cell subsets of multiple sclerosis patients: different features in primary progressive disease (2001) (54)
- Everolimus-Treated Renal Transplant Recipients Have a More Robust CMV-Specific CD8+ T-Cell Response Compared With Cyclosporine- or Mycophenolate-Treated Patients (2013) (54)
- CD97 neutralisation increases resistance to collagen-induced arthritis in mice (2006) (53)
- Differential effect of transforming growth factor-beta 1 on the activation of human naive and memory CD4+ T lymphocytes. (1994) (52)
- Cutting Edge: Virus Selectively Primes Human Langerhans Cells for CD70 Expression Promoting CD8+ T Cell Responses (2011) (51)
- Comparison of human B cell antigen receptor complexes: membrane- expressed forms of immunoglobulin (Ig)M, IgD, and IgG are associated with structurally related heterodimers (1992) (51)
- Rapamycin Does Not Induce Anergy but Inhibits Expansion and Differentiation of Alloreactive Human T Cells (2006) (50)
- Blimp‐1 induces and Hobit maintains the cytotoxic mediator granzyme B in CD8 T cells (2018) (50)
- The Transcription Factor Hobit Identifies Human Cytotoxic CD4+ T Cells (2017) (49)
- Infection History Determines the Differentiation State of Human CD8+ T Cells (2015) (49)
- Common gamma chain cytokines: dissidence in the details. (2007) (48)
- Alloantigen-induced regulatory CD8+CD103+ T cells. (2008) (48)
- Non‐mitogenic T cell activation signals are sufficient for induction of human immunodeficiency virus transcription (1991) (48)
- Human Cytomegalovirus Infection Induces a Rapid and Sustained Change in the Expression of NK Cell Receptors on CD8+ T Cells1 (2008) (47)
- Kawasaki disease: a maturational defect in immune responsiveness. (1999) (47)
- Structure of the human CD97 gene: exon shuffling has generated a new type of seven-span transmembrane molecule related to the secretin receptor superfamily. (1996) (46)
- The Contribution of Cytomegalovirus Infection to Immune Senescence Is Set by the Infectious Dose (2018) (46)
- Recombinant interferon-beta blocks proliferation but enhances interleukin-10 secretion by activated human T-cells. (1996) (46)
- Characterization of CD4+ memory T cell responses directed against common respiratory pathogens in peripheral blood and lung. (2007) (45)
- Cellular immune responses during high-dose interferon-alpha induction therapy for hepatitis C virus infection. (2009) (45)
- Report from the second cytomegalovirus and immunosenescence workshop (2011) (45)
- Identification of a novel subpopulation of germinal center B cells characterized by expression of IgD and CD70 (1996) (44)
- Bispecific antibody-mediated target cell-specific costimulation of resting T cells via CD5 and CD28. (1995) (44)
- Seasonal variation in immune measurements and MRI markers of disease activity in MS (2002) (42)
- Graft-versus-host-like disease complicating thymoma: lack of AIRE expression as a cause of non-hereditary autoimmunity? (2007) (41)
- Cytomegalovirus (CMV) research in immune senescence comes of age: overview of the 6th International Workshop on CMV and Immunosenescence (2017) (40)
- A fingerprint left by cytomegalovirus infection in the human T cell compartment. (2008) (40)
- Restoration of T cell function in chronic hepatitis B patients upon treatment with interferon based combination therapy. (2016) (40)
- Cure of disseminated xenografted human Hodgkin's tumors by bispecific monoclonal antibodies and human T cells: the role of human T-cell subsets in a preclinical model. (1996) (39)
- Effects of IL-4, IL-5, and IL-6 on growth and immunoglobulin production of Epstein-Barr virus-infected human B cells. (1992) (39)
- Functional re-expression of CCR7 on CMV-specific CD8+ T cells upon antigenic stimulation. (2005) (39)
- Children with chronic renal failure have reduced numbers of memory B cells (2004) (37)
- Circulating lymphocyte subsets in different clinical situations after renal transplantation (2012) (37)
- CD70 expression on T-cell subpopulations: study of normal individuals and patients with chronic immune activation. (1997) (36)
- Cutting Edge: CD95 Maintains Effector T Cell Homeostasis in Chronic Immune Activation (2005) (36)
- Alternative molecular form of human T cell‐specific antigen CD27 expressed upon T cell activation (1989) (35)
- Analysis of stem-cell-like properties of human CD161++IL-18Rα+ memory CD8+ T cells. (2012) (34)
- Regulatory properties of LFA-1 alpha and beta chains in human T-lymphocyte activation. (1988) (34)
- Human virus‐specific CD8+ T cells: diversity specialists (2006) (33)
- CD30‐antigen‐specific targeting and activation of T cells via murine bispecific monoclonal antibodies against CD3 and CD28: Potential use for the treatment of hodgkin's lymphoma (1993) (33)
- BH3-only protein Noxa regulates apoptosis in activated B cells and controls high-affinity antibody formation. (2012) (33)
- Type I IFNs differentially modulate IL-12p70 production by human dendritic cells depending on the maturation status of the cells and counteract IFN-gamma-mediated signaling. (2003) (33)
- Rapamycin Enhances the Number of Alloantigen-Induced Human CD103+CD8+ Regulatory T Cells In Vitro (2007) (33)
- A reversion of an IL2RG mutation in combined immunodeficiency providing competitive advantage to the majority of CD8+ T cells (2013) (33)
- Mechanism of inhibition and induction of cytolytic activity in cytotoxic T lymphocytes by CD3 monoclonal antibodies. (1987) (33)
- Expansion of effector T cells associated with decreased PD-1 expression in patients with indolent B cell lymphomas and chronic lymphocytic leukemia (2012) (32)
- Phenotypic and Functional Characterization of Circulating Polyomavirus BK VP1-Specific CD8+ T Cells in Healthy Adults (2013) (31)
- Hobit identifies tissue-resident memory T cell precursors that are regulated by Eomes (2021) (30)
- Influence of CD28 co-stimulation on cytokine production is mainly regulated via interleukin-2. (1994) (29)
- Differential sensitivity of human naive and memory CD4+ T cells for dexamethasone. (1995) (29)
- Continuous CD27 triggering in vivo strongly reduces NK cell numbers (2010) (29)
- Anti-CD3 murine monoclonal isotype switch variants tested for toxicity and immunologic monitoring in four chimpanzees. (1990) (29)
- Clonal Evolution of CD8+ T Cell Responses against Latent Viruses: Relationship among Phenotype, Localization, and Function (2014) (28)
- Pro-Apoptotic Protein Noxa Regulates Memory T Cell Population Size and Protects against Lethal Immunopathology (2013) (28)
- T cell subpopulation phenotypes in filarial infections: CD27 negativity defines a population greatly enriched for Th2 cells. (1994) (27)
- Regulation of T-cell differentiation by CD2 and CD28 accessory molecules. (1991) (27)
- Monitoring the T-Cell Receptor Repertoire at Single-Clone Resolution (2006) (27)
- Tolerance to factor VIII in a transgenic mouse expressing human factor VIII cDNA carrying an Arg593 to Cys substitution (2006) (27)
- Maturation- and differentiation-dependent responsiveness of human CD4+ T helper subsets. (1992) (27)
- Label-free Analysis of CD8+ T Cell Subset Proteomes Supports a Progressive Differentiation Model of Human-Virus-Specific T Cells. (2017) (26)
- A New Subset of Human Naive CD8+ T Cells Defined by Low Expression of IL-7Rα1 (2007) (25)
- TNFα production by CD4+ T cells predicts long-term increase in lesion load on MRI in MS (2001) (24)
- Generation of alloreactive cytolytic T lymphocytes by immobilized anti-CD3 monoclonal antibodies. Analysis of requirements for human cytolytic T-lymphocyte differentiation. (1990) (24)
- Divergent SARS-CoV-2-specific T and B cell responses in severe but not mild COVID-19 (2020) (24)
- Withdrawal symptoms on display: Bcl-2 members under investigation. (2007) (24)
- Chronic CD70-Driven Costimulation Impairs IgG Responses by Instructing T Cells to Inhibit Germinal Center B Cell Formation through FasL-Fas Interactions1 (2009) (24)
- CD70-Driven Chronic Immune Activation Is Protective against Atherosclerosis (2010) (24)
- Differentiation of Human Alloreactive CD4+ and CD8+ T Cells In Vitro (2004) (23)
- Enhanced CD8 T Cell Responses through GITR-Mediated Costimulation Resolve Chronic Viral Infection (2015) (23)
- Expression of IL‐7Rα and KLRG1 defines functionally distinct CD8+ T‐cell populations in humans (2019) (22)
- CXCR5+CD4+ follicular helper T cells accumulate in resting human lymph nodes and have superior B cell helper activity. (2014) (22)
- Simultaneous regulation of CD2 adhesion and signaling functions by a novel CD2 monoclonal antibody. (1994) (22)
- CD27-CD70 interaction: unravelling its implication in normal and neoplastic B-cell growth. (1995) (22)
- CD70-Driven Costimulation Induces Survival or Fas-Mediated Apoptosis of T Cells Depending on Antigenic Load (2012) (22)
- Rapid T cell repopulation after rabbit anti‐thymocyte globulin (rATG) treatment is driven mainly by cytomegalovirus (2012) (22)
- Architecture of the human B-cell antigen receptors. (1993) (20)
- A Novel Role for CD55 in Granulocyte Homeostasis and Anti-Bacterial Host Defense (2011) (20)
- Cutting Edge: Distinct NK Receptor Profiles Are Imprinted on CD8 T Cells in the Mucosa and Periphery during the Same Antigen Challenge: Role of Tissue-Specific Factors1 (2007) (20)
- Viral double-stranded RNA sensors induce antiviral, pro-inflammatory, and pro-apoptotic responses in human renal tubular epithelial cells. (2012) (20)
- Analysis of the role of leukocyte function-associated antigen-1 in activation of human influenza virus-specific T cell clones. (1990) (18)
- Cutting Edge: Distinct NK receptor profiles are imprinted on CD8 T cells in the mucosa and periphery during the same antigen challenge: role of tissue-specific factors. (2007) (17)
- Induction and maintenance of CD8+ T cells specific for persistent viruses. (2007) (16)
- Serum levels of soluble CD27 in renal transplant recipients. (1992) (16)
- Aberrant humoral immune reactivity in DOCK8 deficiency with follicular hyperplasia and nodal plasmacytosis. (2013) (16)
- Two monoclonal anti‐CD3 antibodies can induce different events in human T lymphocyte activation (1987) (16)
- Alteration of B-cell Antigen Receptor Signaling by CD19 Co-ligation. (1996) (16)
- Function of CD27 in helper T cell differentiation. (2011) (15)
- Heterogeneity in both cytokine production and responsiveness of a panel of monoclonal human Epstein-Barr virus-transformed B-cell lines. (1991) (14)
- Antigen receptor function in chronic lymphocytic leukemia B cells. (1996) (14)
- Clinically Relevant Reactivation of Polyomavirus BK (BKPyV) in HLA-A02-Positive Renal Transplant Recipients Is Associated with Impaired Effector-Memory Differentiation of BKPyV-Specific CD8+ T Cells (2016) (14)
- Comparison of the response to T-cell activation by integrated HIV-1 and HTLV-1 LTR-lacZ vectors. (1995) (14)
- Studies on the monocyte dependence of T-cell proliferation induced by monoclonal antibodies directed against regions I and II of the CD2 antigen. (1989) (13)
- Sevenspan transmembrane molecules: novel receptors involved in leukocyte adhesion. (1996) (13)
- Persistent Detection of Varicella-Zoster Virus DNA in a Previously Healthy Child after Severe Chickenpox (2005) (13)
- Evidence for a direct physical interaction of membrane IgM, IgD, and IgG with the B29 gene product. (1994) (12)
- CD4(+) T-cell dynamics in primary cytomegalovirus infection. (2001) (11)
- A novel mutation in CD132 causes X-CID with defective T-cell activation and impaired humoral reactivity. (2011) (10)
- Characterization of a human plasmacytoma line (1991) (10)
- The price of the CD27–CD70 costimulatory axis: you can't have it all (2006) (9)
- CD8 and CD4 T Cell Populations in Human Kidneys (2021) (9)
- Cytotoxic human CD4(+) T cells. (2008) (9)
- Erratum: Programs for the persistence, vigilance and control of human CD8+ lung-resident memory T cells (2017) (8)
- Characteristics of alloreactive T cells measured before renal transplantation (2012) (8)
- Assessing the replicative history of human T cells. (1999) (8)
- CD28 and T-cell activation. (1995) (7)
- Common variable immunodeficiency and hemophagocytic features associated with a FAS gene mutation. (2011) (7)
- A combined immunodeficiency with oligoclonal CD8+, V beta 3-expressing, cytotoxic T lymphocytes in the peripheral blood. (1992) (7)
- Single-Cell Transcriptomics Reveals Discrete Steps in Regulatory T Cell Development in the Human Thymus. (2021) (6)
- Interferon‐gamma administration after abdominal surgery rescues antigen‐specific helper T cell immune reactivity (2001) (6)
- CD27 contributes to the early systemic immune response to Mycobacterium tuberculosis infection but does not affect outcome. (2006) (6)
- The effects of prednisolone and cyclosporin A on monocyte-dependent and -independent human T-cell proliferation in vitro. (1989) (5)
- Defect of interleukin-2 production and T cell proliferation in atopic patients: restoring ability of the CD28-mediated activation pathway. (1993) (5)
- Mitogenic activity of anti-CD28 MoAb CLB-CD28/1 on peripheral blood mononuclear cells and its cooperation with other anti-T cells MoAb in the activation of purified T lymphocytes. (1990) (5)
- GITR shapes humoral immunity by controlling the balance between follicular T helper cells and regulatory T follicular cells. (2020) (5)
- Tumor immunity requires border patrol to fight the enemy within (2017) (5)
- Upregulation of CXCR3 expression on CD8+ T cells due to the pervasive influence of chronic hepatitis B and C virus infection. (2013) (5)
- PGE2 and the immune response. A central role for prostaglandin E2 in downregulating the inflammatory immune response. (1995) (4)
- The interaction between cytomegalovirus and the human immune system. (2014) (4)
- CMV-specific CD8(pos) T lymphocyte differentiation in latent CMV infection. (2001) (4)
- CD8(POS) lymphocyte dynamics in primary CMV infection. (2001) (4)
- Hobit and Blimp‐1 regulate TRM abundance after LCMV infection by suppressing tissue exit pathways of TRMprecursors (2022) (4)
- Adequate synapse formation between leukemic B cells and effector T cells following stimulation with artificial TCR ligands (2008) (3)
- Non FcR‐binding murine antihuman CD3 monoclonal antibody is capable of productive TCR signalling and induces proliferation in the presence of costimulation (2001) (3)
- Compartmentalization of B-cell antigen receptor functions. (1996) (3)
- Differentiation of CMV-specific CD8(POS) T lymphocytes in primary CMV infection after renal transplantation. (2001) (3)
- Conformational changes in CD45 upon monoclonal antibody crosslinking. (1996) (3)
- Detection of allospecific T cells by intracellular cytokine staining and flowcytometry. (2001) (3)
- Constitutive co-stimulation by B cells is sufficient to trigger T cell-driven autoimmune disease (2010) (2)
- The cellular immune system comes of age. (2017) (2)
- Lymphocyte costimulation: multiple pathways, multiple functions? (1995) (2)
- Polyfunctional pathogen-specific CD4+ T cells reside in the lungs and tumors of NSCLC patients (2022) (1)
- Clinical consequences of primary CMV infection after renal transplantation: a case–control study (2020) (1)
- Surface expression of immunoglobulin isotypes on primary human B cells: no evidence for glycosyl-phosphatidylinositol linkage. (1993) (1)
- Protein kinase C regulates secretion of lymphotoxin (LT/TNF beta) and TNF alpha by human EBV-transformed B cells. (1992) (1)
- How to Reliably Define Human CD8+ T-Cell Subsets: Markers Playing Tricks. (2021) (1)
- The bug in MyD88 dependency. (2006) (1)
- Regulation of NF-kappa B nuclear activity in peripheral blood mononuclear cells: role of CD28 antigen. (1994) (1)
- Hobit and Blimp‐1 instruct the differentiation of iNKT cells into resident‐phenotype lymphocytes after lineage commitment (2021) (1)
- Immune checkpoint blockade: Which switches to hit and how much? (2016) (1)
- Expression of the IL-6 gene induces differentiation of a human monoclonal EBV-transformed B cell line. (1993) (0)
- Allo-reactive tissue-resident T cells causing damage: An inside job (2022) (0)
- The pyrimidin analogue cyclopentenyl cytosine induces alloantigen‐specific non‐responsiveness of human T lymphocytes (2008) (0)
- CMV and Immunosenescence: from basics to clinics (2012) (0)
- Response to Comment on “Differential Usage of Cellular Niches by Cytomegalovirus versus EBV- and Influenza Virus-Specific CD8+ T Cells” (2007) (0)
- Tissue-resident memory T cells populate the human brain (2018) (0)
- EFIS - Building an European Immunology Community. (2017) (0)
- [Signals for cellular selection for life and death by a new family of cytokines]. (1996) (0)
- Tissue-resident memory T cells at the center of immunity to solid tumors (2018) (0)
- [Soluble T-cell-membrane molecules; a measure for in-vivo T-cell activation]. (1992) (0)
- Dutch immunology: vibrant throughout the years. (2012) (0)
- Cytomegalovirus (CMV) research in immune senescence comes of age: overview of the 6th International Workshop on CMV and Immunosenescence (2017) (0)
- News and EFIS (2012) (0)
- Effect of IL-6 on proliferation and IG production of human EBV-transformed cell lines in serum free culture media. (1990) (0)
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