Richard Bruce Silverman
#7,101
Most Influential Person Now
American chemist
Richard Bruce Silverman's AcademicInfluence.com Rankings
Download Badge
Chemistry
Richard Bruce Silverman's Degrees
- Bachelors Chemistry Pennsylvania State University
Why Is Richard Bruce Silverman Influential?
(Suggest an Edit or Addition)According to Wikipedia, Richard Bruce Silverman is the Patrick G. Ryan/Aon Professor of Chemistry at Northwestern University. His group's main focus is basic and translational research into central nervous system disorders and cancer. He is known for the discovery of pregabalin, which is marketed by Pfizer under the brand name Lyrica.
Richard Bruce Silverman's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The Organic Chemistry of Drug Design and Drug Action (1992) (623)
- Celastrols as Inducers of the Heat Shock Response and Cytoprotection*[boxs] (2004) (413)
- Mechanism-based enzyme inactivation : chemistry and enzymology (1988) (273)
- Inducible nitric oxide synthase: Regulation, structure, and inhibition (2020) (252)
- Activation of heat shock and antioxidant responses by the natural product celastrol: transcriptional signatures of a thiol-targeted molecule. (2007) (228)
- Mechanism-based enzyme inactivators. (1995) (222)
- Radical Ideas about Monoamine Oxidase (1995) (206)
- The Organic Chemistry of Enzyme Catalyzed Reactions (2012) (184)
- Potent and selective inhibition of neuronal nitric oxide synthase by N(ω)-propyl-L-arginine (1997) (184)
- The sirtuin 2 inhibitor AK-7 is neuroprotective in Huntington's disease mouse models. (2012) (174)
- CaV1.3-selective L-type calcium channel antagonists as potential new therapeutics for Parkinson's disease (2012) (141)
- Structures of γ-Aminobutyric Acid (GABA) Aminotransferase, a Pyridoxal 5′-Phosphate, and [2Fe-2S] Cluster-containing Enzyme, Complexed with γ-Ethynyl-GABA and with the Antiepilepsy Drug Vigabatrin* (2003) (132)
- Target- and mechanism-based therapeutics for neurodegenerative diseases: strength in numbers. (2013) (115)
- Revisiting heme mechanisms. A perspective on the mechanisms of nitric oxide synthase (NOS), Heme oxygenase (HO), and cytochrome P450s (CYP450s). (2008) (110)
- Design, synthesis, and biological activity of a difluoro-substituted, conformationally rigid vigabatrin analogue as a potent gamma-aminobutyric acid aminotransferase inhibitor. (2003) (110)
- From basic science to blockbuster drug: the discovery of Lyrica. (2008) (110)
- A mechanism for mitochondrial monoamine oxidase catalyzed amine oxidation (1980) (108)
- Syntheses of (S)-5-substituted 4-aminopentanoic acids: a new class of .gamma.-aminobutyric acid transaminase inactivators (1980) (105)
- The Sirtuin-2 Inhibitor AK7 Is Neuroprotective in Models of Parkinson’s Disease but Not Amyotrophic Lateral Sclerosis and Cerebral Ischemia (2015) (103)
- Design of selective neuronal nitric oxide synthase inhibitors for the prevention and treatment of neurodegenerative diseases. (2009) (95)
- 3-Alkyl GABA and 3-alkylglutamic acid analogues: two new classes of anticonvulsant agents (1992) (90)
- A new class of conformationally rigid analogues of 4-amino-5-halopentanoic acids, potent inactivators of gamma-aminobutyric acid aminotransferase. (2000) (87)
- Chemical Model Studies for the Mechanism of Vitamin K Epoxide Reductase (1981) (85)
- Minimal pharmacophoric elements and fragment hopping, an approach directed at molecular diversity and isozyme selectivity. Design of selective neuronal nitric oxide synthase inhibitors. (2008) (84)
- 3-Alkyl-4-aminobutyric acids: the first class of anticonvulsant agents that activates L-glutamic acid decarboxylase. (1991) (81)
- Discovery of highly potent and selective inhibitors of neuronal nitric oxide synthase by fragment hopping. (2009) (77)
- Mechanisms of inactivation of γ-aminobutyric acid aminotransferase by the antiepilepsy drug γ-vinyl GABA (vigabatrin) (1991) (72)
- Mechanism of inactivation of monoamine oxidase by trans-2-phenylcyclopropylamine and the structure of the enzyme-inactivator adduct. (1983) (72)
- Selective neuronal nitric oxide synthase inhibitors and the prevention of cerebral palsy (2009) (70)
- Reduced thioredoxin: a possible physiological cofactor for vitamin K epoxide reductase. Further support for an active site disulfide. (1988) (70)
- Computer modeling of selective regions in the active site of nitric oxide synthases: implication for the design of isoform-selective inhibitors. (2003) (69)
- Structural basis for dipeptide amide isoform-selective inhibition of neuronal nitric oxide synthase (2004) (68)
- Development of nitric oxide synthase inhibitors for neurodegeneration and neuropathic pain. (2014) (67)
- N-methylsansalvamide a peptide analogues. Potent new antitumor agents. (2005) (66)
- Inactivation of pyridoxal phosphate dependent enzymes by mono- and polyhaloalanines. (1976) (64)
- Serotonergic signalling suppresses ataxin 3 aggregation and neurotoxicity in animal models of Machado-Joseph disease. (2015) (64)
- Microsporins A and B: new histone deacetylase inhibitors from the marine-derived fungus Microsporum cf. gypseum and the solid-phase synthesis of microsporin A (2007) (61)
- 3-pyrrolines are mechanism-based inactivators of the quinone-dependent amine oxidases but only substrates of the flavin-dependent amine oxidases. (2002) (60)
- Celastrol analogues as inducers of the heat shock response. Design and synthesis of affinity probes for the identification of protein targets. (2012) (60)
- Development of Nitric Oxide Synthase Inhibitors for Neurodegeneration and Neuropathic Pain (2014) (59)
- A modulator of wild-type glucocerebrosidase improves pathogenic phenotypes in dopaminergic neuronal models of Parkinson’s disease (2019) (59)
- Design of potential anticonvulsant agents: mechanistic classification of GABA aminotransferase inactivators. (1989) (59)
- Nω-Nitroarginine-Containing Dipeptide Amides. Potent and Highly Selective Inhibitors of Neuronal Nitric Oxide Synthase (1999) (59)
- Model chemistry for a covalent mechanism of action of orotidine 5'-phosphate decarboxylase (1982) (58)
- Mechanism of inactivation of monoamine oxidase by 1-phenylcyclopropylamine. (1985) (57)
- Reduced amide bond peptidomimetics. (4S)-N-(4-amino-5-[aminoakyl]aminopentyl)-N'-nitroguanidines, potent and highly selective inhibitors of neuronal nitric oxide synthase. (2001) (55)
- Mechanism of inactivation of gamma-aminobutyric acid-alpha-ketoglutaric acid aminotransferase by 4-amino-5-halopentanoic acids. (1981) (53)
- Short, highly efficient syntheses of protected 3-azido- and 4-azidoproline and their precursors. (2001) (51)
- Model studies for a molecular mechanism of action of oral anticoagulants (1981) (50)
- Targeting nitric oxide signaling with nNOS inhibitors as a novel strategy for the therapy and prevention of human melanoma. (2013) (50)
- Unexpected binding modes of nitric oxide synthase inhibitors effective in the prevention of a cerebral palsy phenotype in an animal model. (2010) (49)
- Mechanism of inactivation of inducible nitric oxide synthase by amidines. Irreversible enzyme inactivation without inactivator modification. (2005) (48)
- Mechanism-based inactivation of mitochondrial monoamine oxidase by N-(1-methylcyclopropyl)benzylamine. (1984) (48)
- Exploration of the active site of neuronal nitric oxide synthase by the design and synthesis of pyrrolidinomethyl 2-aminopyridine derivatives. (2010) (48)
- Solid-phase, Pd-catalyzed silicon-aryl carbon bond formation. Synthesis of sansalvamide A peptide. (2002) (47)
- Potent, highly selective, and orally bioavailable gem-difluorinated monocationic inhibitors of neuronal nitric oxide synthase. (2010) (47)
- Model studies for coenzyme B12 dependent enzyme-catalyzed rearrangements. Evidence for cobalt(III)-olefin pi complexes. (1976) (47)
- Remarkable stereospecific conjugate additions to the Hsp90 inhibitor celastrol. (2011) (46)
- Enzyme Inhibition and Inactivation (2004) (45)
- Structural and biological studies on bacterial nitric oxide synthase inhibitors (2013) (44)
- Fluorinated Conformationally-Restricted γ-Aminobutyric Acid Aminotransferase Inhibitors (2006) (44)
- Mutation of surface cysteine 374 to alanine in monoamine oxidase A alters substrate turnover and inactivation by cyclopropylamines. (2005) (43)
- Pyrimidine-2,4,6-trione derivatives and their inhibition of mutant SOD1-dependent protein aggregation. Toward a treatment for amyotrophic lateral sclerosis. (2011) (42)
- Mechanism of nitric oxide synthase. Evidence that direct hydrogen atom abstraction from the O-H bond of NG-hydroxyarginine is not relevant to the mechanism. (2001) (41)
- Carbonyl- and sulfur-containing analogs of suberoylanilide hydroxamic acid: Potent inhibition of histone deacetylases. (2006) (40)
- ADME-guided design and synthesis of aryloxanyl pyrazolone derivatives to block mutant superoxide dismutase 1 (SOD1) cytotoxicity and protein aggregation: potential application for the treatment of amyotrophic lateral sclerosis. (2012) (40)
- Aromatic reduced amide bond peptidomimetics as selective inhibitors of neuronal nitric oxide synthase. (2003) (40)
- Mechanism of inactivation of ?-cystathionase by ,,-trifluoroalanine (1977) (40)
- A novel peptide sansalvamide analogue inhibits pancreatic cancer cell growth through G0/G1 cell-cycle arrest. (2006) (39)
- Mechanism of inactivation of mitochondrial monoamine oxidase by N-cyclopropyl-N-arylalkyl amines (1980) (39)
- Selective neuronal nitric oxide synthase inhibitors. (2005) (39)
- (1S, 3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a potent γ-aminobutyric acid aminotransferase inactivator for the treatment of cocaine addiction. (2012) (38)
- Proteasome Activation is a Mechanism for Pyrazolone Small Molecules Displaying Therapeutic Potential in Amyotrophic Lateral Sclerosis (2014) (38)
- A Model for a Molecular Mechanism of Anticoagulant Activity of 3-Substituted 4-Hydroxycoumarins (1980) (38)
- Selective inhibition of gamma-aminobutyric acid aminotransferase by (3R,4R),(3S,4S)- and (3R,4S),(3S,4R)-4-amino-5-fluoro-3-phenylpentanoic acids. (1990) (37)
- Intramolecular hydrogen bonding: a potential strategy for more bioavailable inhibitors of neuronal nitric oxide synthase. (2012) (37)
- Analogues of 2-aminopyridine-based selective inhibitors of neuronal nitric oxide synthase with increased bioavailability. (2009) (37)
- Potent and Selective Double-Headed Thiophene-2-carboximidamide Inhibitors of Neuronal Nitric Oxide Synthase for the Treatment of Melanoma (2014) (37)
- Antagonism of 4-substituted 1,4-dihydropyridine-3,5-dicarboxylates toward voltage-dependent L-type Ca2+ channels Ca V 1.3 and Ca V 1.2. (2010) (37)
- Mechanism of inactivation of gamma-aminobutyrate aminotransferase by 4-amino-5-fluoropentanoic acid. First example of an enamine mechanism for a gamma-amino acid with a partition ratio of 0. (1986) (37)
- Selective inhibition of neuronal nitric oxide synthase by N omega-nitroarginine-and phenylalanine-containing dipeptides and dipeptide esters. (1997) (37)
- Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase . (2010) (37)
- Identification of compounds protective against G93A-SOD1 toxicity for the treatment of amyotrophic lateral sclerosis (2011) (36)
- 2,6-Difluorophenol as a bioisostere of a carboxylic acid: bioisosteric analogues of gamma-aminobutyric acid. (1999) (36)
- Electrostatic Control of Isoform Selective Inhibitor Binding in Nitric Oxide Synthase. (2016) (36)
- Symmetric double-headed aminopyridines, a novel strategy for potent and membrane-permeable inhibitors of neuronal nitric oxide synthase. (2011) (36)
- Potent and selective inhibition of neuronal nitric oxide synthase by N omega-propyl-L-arginine. (1997) (36)
- A Convenient Synthesis of 3-Alkyl-4-aminobutanoic Acids (1989) (35)
- Design and Mechanism of GABA Aminotransferase Inactivators. Treatments for Epilepsies and Addictions. (2018) (35)
- The organic chemistry of mechanism‐based enzyme inhibition: A chemical approach to drug design (1984) (35)
- The potential use of mechanism-based enzyme inactivators in medicine. (1988) (35)
- Inactivation and inhibition of gamma-aminobutyric acid aminotransferase by conformationally restricted vigabatrin analogues. (2002) (35)
- Design and Mechanism of (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic Acid, a Highly Potent γ-Aminobutyric Acid Aminotransferase Inactivator for the Treatment of Addiction. (2018) (34)
- A direct method for cobalt-carbon bond formation in cobalt(3)-containing cobalamins and cobaloximes. Further support for cobalt(3). Complexes in coenzyme B 12 dependent rearrangements. (1973) (34)
- Suppression of Hepatocellular Carcinoma by Inhibition of Overexpressed Ornithine Aminotransferase. (2015) (34)
- Simplified 2-Aminoquinoline-Based Scaffold for Potent and Selective Neuronal Nitric Oxide Synthase Inhibition (2014) (34)
- Mild and selective sodium azide mediated cleavage of p-nitrobenzoic esters. (2001) (34)
- 5-(Aminomethyl)-3-aryl-2-oxazolidinones. A novel class of mechanism-based inactivators of monoamine oxidase B (1990) (33)
- Structures of human constitutive nitric oxide synthases. (2014) (33)
- Identification of the amino acid bound to the labile adduct formed during inactivation of monoamine oxidase by 1-phenylcyclopropylamine. (1986) (33)
- Identification of the Active Site Cysteine in Bovine Liver Monoamine Oxidase B (1997) (32)
- Direct continuous fluorometric assay for monoamine oxidase B. (1996) (32)
- Structure-based design and synthesis of N(omega)-nitro-L-arginine-containing peptidomimetics as selective inhibitors of neuronal nitric oxide synthase. Displacement of the heme structural water. (2007) (32)
- Rapid, high-yield, solid-phase synthesis of the antitumor antibiotic sansalvamide A using a side-chain-tethered phenylalanine building block. (2000) (32)
- New substrates and inhibitors of gamma-aminobutyric acid aminotransferase containing bioisosteres of the carboxylic acid group: design, synthesis, and biological activity. (2006) (32)
- Enantiomers of 4-amino-3-fluorobutanoic acid as substrates for gamma-aminobutyric acid aminotransferase. Conformational probes for GABA binding. (2007) (32)
- An Aromatization Mechanism of Inactivation of γ-Aminobutyric Acid Aminotransferase for the Antibiotic l-Cycloserine (1998) (31)
- Hypoxia–ischemia causes persistent movement deficits in a perinatal rabbit model of cerebral palsy: assessed by a new swim test (2009) (31)
- Design of a conformationally restricted analogue of the antiepilepsy drug Vigabatrin that directs its mechanism of inactivation of gamma-aminobutyric acid aminotransferase. (2002) (31)
- Syntheses and evaluation of fluorinated conformationally restricted analogues of GABA as potential inhibitors of GABA aminotransferase. (2006) (31)
- 1-Phenylcyclobutylamine, the first in a new class of monoamine oxidase inactivators. Further evidence for a radical intermediate. (1986) (30)
- Regulation of aldosterone secretion by Cav1.3 (2016) (30)
- ENDOR spectroscopic evidence for the position and structure of NG-hydroxy-L-arginine bound to holo-neuronal nitric oxide synthase. (1999) (30)
- Neuronal Nitric Oxide Synthase Inhibition Prevents Cerebral Palsy following Hypoxia-Ischemia in Fetal Rabbits: Comparison between JI-8 and 7-Nitroindazole (2011) (30)
- Invasive renal cell carcinoma with inferior vena cava tumor thrombus: cardiac anesthesia in liver transplant settings. (2014) (30)
- Effect of alpha-methylation on inactivation of monoamine oxidase by N-cyclopropylbenzylamine. (1984) (30)
- Irreversible inactivation of pig brain γ-aminobutyric acid-α-ketoglutarate transaminase by 4-amino-5-halopentanoic acids (1980) (29)
- The 2011 E. B. Hershberg award for important discoveries in medicinally active substances: (1S,3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a GABA aminotransferase inactivator and new treatment for drug addiction and infantile spasms. (2012) (29)
- Synthesis and evaluation of peptidomimetics as selective inhibitors and active site probes of nitric oxide synthases. (2000) (28)
- Inactivation of monoamine oxidase by (aminomethyl)cubane. First evidence for an .alpha.-amino radical during enzyme catalysis (1993) (28)
- Inhibition and substrate activity of conformationally rigid vigabatrin analogues with gamma-aminobutyric acid aminotransferase. (1999) (28)
- Solid-phase total synthesis of scytalidamide A. (2003) (28)
- Structures of the neuronal and endothelial nitric oxide synthase heme domain with D-nitroarginine-containing dipeptide inhibitors bound. (2004) (27)
- Observation of a flavin semiquinone in the resting state of monoamine oxidase B by electron paramagnetic resonance and electron nuclear double resonance spectroscopy. (1996) (27)
- Ornithine Aminotransferase versus GABA Aminotransferase: Implications for the Design of New Anticancer Drugs (2015) (27)
- Mechanistic crystallography. Mechanism of inactivation of gamma-aminobutyric acid aminotransferase by (1R,3S,4S)-3-amino-4-fluorocyclopentane-1-carboxylic acid as elucidated by crystallography. (2004) (27)
- Development and characterization of 3-(benzylsulfonamido)benzamides as potent and selective SIRT2 inhibitors. (2014) (27)
- Revised mechanism for inactivation of mitochondrial monoamine oxidase by N-cyclopropylbenzylamine. (1985) (26)
- Aminoalkyl)trimethylsilanes. A new class of monoamine oxidase inactivators (1987) (26)
- Synthesis and evaluation of novel aromatic substrates and competitive inhibitors of GABA aminotransferase. (2008) (26)
- Slow-Binding Inhibition of γ-Aminobutyric Acid Aminotransferase by Hydrazine Analogues†,‡ (1996) (25)
- Antagonism of L-type Ca2+ channels CaV1.3 and CaV1.2 by 1,4-dihydropyrimidines and 4H-pyrans as dihydropyridine mimics. (2013) (25)
- Mechanism of inactivation of .gamma.-aminobutyric acid aminotransferase by 4-amino-5-hexynoic acid (.gamma.-ethynyl GABA) (1991) (25)
- A model for the mechanism of action of coenzyme B 12 dependent enzymes. Evidence for sigma leads to pi rearrangements in cobaloximes. (1972) (25)
- Isolation and characterization of the product of inactivation of gamma-aminobutyric acid aminotransferase by gabaculine. (1999) (25)
- Imidazole-containing amino acids as selective inhibitors of nitric oxide synthases. (1999) (25)
- Stereospecific total syntheses of proteasome inhibitors omuralide and lactacystin. (2011) (25)
- Design of Selective Neuronal Nitric Oxide Synthase Inhibitors for the Prevention and Treatment of Neurodegenerative Diseases (2009) (24)
- Evidence for a hydrogen atom transfer mechanism or a proton/fast electron transfer mechanism for monoamine oxidase (1992) (24)
- Unusual Mechanistic Difference in the Inactivation of γ-Aminobutyric Acid Aminotransferase by (E)- and (Z)-4-Amino-6-fluoro-5-hexenoic Acid (1996) (24)
- Novel 2,4-Disubstituted Pyrimidines as Potent, Selective, and Cell-Permeable Inhibitors of Neuronal Nitric Oxide Synthase (2014) (24)
- N-(1-Methyl)cyclopropylbenzylamine: a novel inactivator of mitochondrial monoamine oxidase. (1981) (24)
- Silver(I)/peroxydisulfate-induced oxidative decarboxylation of amino acids. A chemical model for a possible intermediate in the monoamine oxidase-catalyzed oxidation of amines (1992) (23)
- The use of mechanism-based inactivators to probe the mechanism of monoamine oxidase. (1991) (23)
- Mechanistic Studies of the Inactivation of Inducible Nitric Oxide Synthase by N5-(1-Iminoethyl)-l-ornithine (l-NIO) (1999) (23)
- 4-Amino-3-alkylbutanoic acids as substrates for gamma-aminobutyric acid aminotransferase. (1990) (23)
- Structure-activity relationship of N,N'-disubstituted pyrimidinetriones as Ca(V)1.3 calcium channel-selective antagonists for Parkinson's disease. (2013) (23)
- Involvement of Neuronal Nitric Oxide Synthase in Ongoing Fetal Brain Injury following Near-Term Rabbit Hypoxia-Ischemia (2011) (23)
- Structure-guided design of selective inhibitors of neuronal nitric oxide synthase. (2013) (23)
- Potent and selective conformationally restricted neuronal nitric oxide synthase inhibitors. (2004) (23)
- Inactivation of monoamine oxidase A by the monoamine oxidase B inactivators 1-phenylcyclopropylamine, 1-benzylcyclopropylamine, and N-cyclopropyl-alpha-methylbenzylamine. (1988) (22)
- Efficient solid-phase synthesis of compounds containing phenylalanine and its derivatives via side-chain attachment to the polymer support (1999) (22)
- Partial neuroprotection by nNOS inhibition during profound asphyxia in preterm fetal sheep (2013) (22)
- Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2-Aminoquinoline Inhibitors. (2017) (22)
- Arylsulfanyl pyrazolones block mutant SOD1-G93A aggregation. Potential application for the treatment of amyotrophic lateral sclerosis. (2011) (22)
- Enantiomers of cis-constrained and flexible 2-substituted GABA analogues exert opposite effects at recombinant GABA(C) receptors. (2006) (22)
- Theoretical Studies on NG-Hydroxy-l-arginine and Derived Radicals: Implications for the Mechanism of Nitric Oxide Synthase (2000) (22)
- Selective L-nitroargininylaminopyrrolidine and L-nitroargininylaminopiperidine neuronal nitric oxide synthase inhibitors. (2007) (22)
- Mechanism of inactivation of monoamine oxidase B by (aminomethyl)trimethylsilane (1990) (21)
- Selective monocationic inhibitors of neuronal nitric oxide synthase. Binding mode insights from molecular dynamics simulations. (2012) (21)
- Phenyl Ether- and Aniline-Containing 2-Aminoquinolines as Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase. (2015) (21)
- Mechanism of inactivation of neuronal nitric oxide synthase by N(ω)-allyl-L-arginine (1997) (21)
- Substituted 4-aminobutanoic acids. Substrates for gamma-aminobutyric acid alpha-ketoglutaric acid aminotransferase. (1981) (21)
- nNOS inhibition during profound asphyxia reduces seizure burden and improves survival of striatal phenotypic neurons in preterm fetal sheep (2014) (21)
- Mechanism of Inactivation of γ-Aminobutyric Acid Aminotransferase by (1S,3S)-3-Amino-4-difluoromethylene-1-cyclopentanoic Acid (CPP-115) (2015) (21)
- A cellular model for screening neuronal nitric oxide synthase inhibitors. (2009) (21)
- Traceless Solid-Phase Synthesis of Chiral 3-Aryl β-Amino Acid Containing Peptides Using a Side-Chain-Tethered β-Amino Acid Building Block (2000) (21)
- Cyclohexane 1,3-diones and their inhibition of mutant SOD1-dependent protein aggregation and toxicity in PC12 cells. (2012) (21)
- Optimization of Blood-Brain Barrier Permeability with Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibitors Having a 2-Aminopyridine Scaffold. (2019) (20)
- 4-Amino-2-(substituted methyl)-2-butenoic acids: substrates and potent inhibitors of gamma-aminobutyric acid aminotransferase. (1986) (20)
- Peripheral but crucial: a hydrophobic pocket (Tyr(706), Leu(337), and Met(336)) for potent and selective inhibition of neuronal nitric oxide synthase. (2010) (20)
- PLP and GABA trigger GabR-mediated transcription regulation in Bacillus subtilis via external aldimine formation (2017) (20)
- Model studies for coenzyme B12 dependent enzyme-catalyzed rearrangements. Kinetics and mechanism of decomposition of formylmethylcobalamin and its acetals. (1976) (20)
- Model studies for the mechanism of inactivation of monoamine oxidase by 5-(aminomethyl)-3-aryl-2-oxazolidinones (1989) (20)
- STEREOSPECIFIC TOTAL SYNTHESES OF THE NATURAL ANTITUMOR AGENT, (αS, 5S)-α-AMINO-3-CHLORO-4,5-DIHYDRO-5-ISOXAZOLEACETIC ACID, AND ITS UNNATURAL C-5 EPIMER (1982) (20)
- Purification of a vitamin K epoxide reductase that catalyzes conversion of vitamin K 2,3-epoxide to 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone. (1985) (20)
- Conformationally restricted dipeptide amides as potent and selective neuronal nitric oxide synthase inhibitors. (2006) (20)
- Mechanisms of Inactivation of γ-Aminobutyric Acid Aminotransferase by 4-Amino-5-fluoro-5-hexenoic Acid (1996) (20)
- Electronic effects of peripheral substituents at porphyrin meso positions. (2007) (20)
- Inactivation of monoamine oxidase by allylamine does not result in flavin attachment. (1985) (20)
- Structural modifications of (1S,3S)-3-amino-4-difluoromethylenecyclopentanecarboxylic acid, a potent irreversible inhibitor of GABA aminotransferase. (2007) (19)
- β-Glucocerebrosidase Modulators Promote Dimerization of β-Glucocerebrosidase and Reveal an Allosteric Binding Site. (2018) (19)
- The Mobility of a Conserved Tyrosine Residue Controls Isoform-Dependent Enzyme–Inhibitor Interactions in Nitric Oxide Synthases (2014) (19)
- Conformationally-restricted arginine analogues as alternative substrates and inhibitors of nitric oxide synthases. (1999) (19)
- New stable backbone linker resins for solid-phase peptide synthesis. (2003) (19)
- Spectrometric evidence for the flavin-1-phenylcyclopropylamine inactivator adduct with monoamine oxidase N. (2001) (19)
- Crystal structures of constitutive nitric oxide synthases in complex with de novo designed inhibitors. (2009) (19)
- Total Synthesis of Tambromycin Enabled by Indole C-H Functionalization. (2018) (18)
- Nitric Oxide Synthase Inhibitors That Interact with Both Heme Propionate and Tetrahydrobiopterin Show High Isoform Selectivity (2014) (18)
- 2-Aminopyridines with a Truncated Side Chain To Improve Human Neuronal Nitric Oxide Synthase Inhibitory Potency and Selectivity. (2015) (18)
- Syntheses of (Z)-and (E)-4-amino-2-(trifluoromethyl)-2-butenoic acid and their inactivation of gamma-aminobutyric acid aminotransferase. (1999) (18)
- Structure-Based Design of Bacterial Nitric Oxide Synthase Inhibitors (2014) (18)
- Electron spin resonance studies of monoamine oxidase B. First direct evidence for a substrate radical intermediate (1989) (18)
- Inactivation of gamma-aminobutyric acid aminotransferase by (S,E)-4-amino-5-fluoropent-2-enoic acid and effect on the enzyme of (E)-3-(1-aminocyclopropyl)-2-propenoic acid. (1986) (18)
- 1H-pyrazole-1-carboxamidines: new inhibitors of nitric oxide synthase. (2000) (18)
- Microwave-assisted protection of primary amines as 2,5-dimethylpyrroles and their orthogonal deprotection. (2013) (17)
- Nitric Oxide Synthase as a Target for Methicillin-Resistant Staphylococcus aureus. (2015) (17)
- Sansalvamide induces pancreatic cancer growth arrest through changes in the cell cycle. (2010) (17)
- Silicon-based aromatic transferring linkers for traceless solid-phase synthesis of aryl-, polyaryl-, and heteroaryl-containing compounds (2001) (16)
- Letter: Reactions of vinyl ethers with cobalamins and cobaloximes. (1974) (16)
- Antenatal insults modify newborn olfactory function by nitric oxide produced from neuronal nitric oxide synthase (2012) (16)
- Heme-coordinating inhibitors of neuronal nitric oxide synthase. Iron-thioether coordination is stabilized by hydrophobic contacts without increased inhibitor potency. (2010) (16)
- Design, synthesis, and biological testing of potential heme-coordinating nitric oxide synthase inhibitors. (2006) (16)
- Substituted pyrazolones require N2 hydrogen bond donating ability to protect against cytotoxicity from protein aggregation of mutant superoxide dismutase 1. (2012) (16)
- Structure-based design, synthesis, and biological evaluation of lipophilic-tailed monocationic inhibitors of neuronal nitric oxide synthase. (2010) (16)
- Exploring the binding conformations of bulkier dipeptide amide inhibitors in constitutive nitric oxide synthases. (2005) (16)
- Transformation of monoamine oxidase-B primary amine substrates into time-dependent inhibitors. Tertiary amine homologues of primary amine substrates. (1993) (16)
- Inactivation of gamma-aminobutyric acid aminotransferase by (Z)-4-amino-2-fluorobut-2-enoic acid. (1988) (16)
- Evidence against a Nucleophilic Mechanism for Monoamine Oxidase-Catalyzed Amine Oxidation (1994) (16)
- (+/-)-(1S,2R,5S)-5-Amino-2-fluorocyclohex-3-enecarboxylic acid. A potent GABA aminotransferase inactivator that irreversibly inhibits via an elimination-aromatization pathway. (2006) (15)
- Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker. (2016) (15)
- Chemoenzymatic Synthesis of (R)- and (S)-4-Amino-3-methylbutanoic Acids (1990) (15)
- A mild method of hydrolysis of 2,4-dialkoxy-6-substituted pyrimidines to 6-substituted uracils (1980) (15)
- Methylated N(ω)-hydroxy-L-arginine analogues as mechanistic probes for the second step of the nitric oxide synthase-catalyzed reaction. (2013) (15)
- Inactivation of Escherichia coli L-aspartate aminotransferase by (S)-4-amino-4,5-dihydro-2-thiophenecarboxylic acid reveals "a tale of two mechanisms". (2007) (15)
- ENDOR studies of L-arginine and N(G)-hydroxy-L-arginine bound to all three holo-nitric oxide synthase isozymes [10] (2000) (15)
- Inactivation of mitochondrial monoamine oxidase B by methylthio-substituted benzylamines. (2003) (15)
- Mevalonate analogues as substrates of enzymes in the isoprenoid biosynthetic pathway of Streptococcus pneumoniae. (2010) (15)
- Formylsilanes. Chemoenzymatic and Chemical Syntheses of the 2,4-Dinitrophenylhydrazones of These Apparently Air- and Water-Stable Compounds (1992) (15)
- Synthesis and evaluation of novel heteroaromatic substrates of GABA aminotransferase. (2012) (15)
- Targeting Bacterial Nitric Oxide Synthase with Aminoquinoline-Based Inhibitors. (2016) (15)
- MONOAMINE OXIDASE B CATALYSIS IN LOW AQUEOUS MEDIUM. DIRECT EVIDENCE FOR AN IMINE PRODUCT (1995) (14)
- Novel Combination of Impella and Extra Corporeal Membrane Oxygenation as a Bridge to Full Recovery in Fulminant Myocarditis (2012) (14)
- Probing Ligand-binding Pockets of the Mevalonate Pathway Enzymes from Streptococcus pneumoniae* (2010) (14)
- Arylazanylpyrazolone derivatives as inhibitors of mutant superoxide dismutase 1 dependent protein aggregation for the treatment of amyotrophic lateral sclerosis. (2013) (14)
- Design and mechanism of tetrahydrothiophene-based γ-aminobutyric acid aminotransferase inactivators. (2015) (14)
- Temperature-dependent spin crossover in neuronal nitric oxide synthase bound with the heme-coordinating thioether inhibitors. (2011) (14)
- Mechanism of inactivation of monoamine oxidase-B by the anticonvulsant agent milacemide (2-(n-pentylamino)acetamide) (1993) (14)
- Mechanism for the Reaction of Tributyltin Radicals with Aldehydes (1992) (14)
- Improved Procedure for the Synthesis of Substituted .beta.-Hydroxy Nitriles (1995) (14)
- Enzymatic and Cryoreduction EPR Studies of the Hydroxylation of Methylated Nω-Hydroxy-l-arginine Analogues by Nitric Oxide Synthase from Geobacillus stearothermophilus (2014) (14)
- 4-substituted cubylcarbinylamines: a new class of mechanism-based monoamine oxidase B inactivators. (1997) (14)
- Monoamine Oxidase B-Catalyzed Oxidation of Cinnamylamine 2,3-Oxide. Further Evidence against a Nucleophilic Mechanism (1994) (14)
- Potent and selective neuronal nitric oxide synthase inhibitors with improved cellular permeability. (2010) (14)
- Chiral cyclohexane 1,3-diones as inhibitors of mutant SOD1-dependent protein aggregation for the treatment of ALS. (2012) (14)
- 5-(Aminomethyl)-3-aryldihydrofuran-2(3H)-ones, a new class of monoamine oxidase-B inactivators. (1992) (14)
- Synthesis and enzymatic evaluation of 2- and 4-aminothiazole-based inhibitors of neuronal nitric oxide synthase (2009) (13)
- Stereoselective ring opening of 1-phenylcyclopropylamine catalyzed by monoamine oxidase-B (1993) (13)
- Transformation of heterocyclic reversible monoamine oxidase-B inactivators into irreversible inactivators by N-methylation. (1993) (13)
- Chemical Model for a Mechanism of Inactivation of Monoamine Oxidase by Heterocyclic Compounds. Electronic Effects on Acetal Hydrolysis (1993) (13)
- Mechanism of Inactivation of γ-Aminobutyric Acid Aminotransferase by (S)-4-Amino-4,5-dihydro-2-thiophenecarboxylic Acid (1999) (13)
- Conformationally-restricted vigabatrin analogs as irreversible and reversible inhibitors of gamma-aminobutyric acid aminotransferase. (2004) (13)
- Improving mitochondria and ER stability helps eliminate upper motor neuron degeneration that occurs due to mSOD1 toxicity and TDP‐43 pathology (2021) (13)
- Cyclopropyl- and methyl-containing inhibitors of neuronal nitric oxide synthase. (2013) (13)
- L337H mutant of rat neuronal nitric oxide synthase resembles human neuronal nitric oxide synthase toward inhibitors. (2009) (13)
- Hydrophilic, Potent, and Selective 7-Substituted 2-Aminoquinolines as Improved Human Neuronal Nitric Oxide Synthase Inhibitors. (2017) (13)
- 3-(N-arylsulfamoyl)benzamides, inhibitors of human sirtuin type 2 (SIRT2). (2012) (13)
- Inactivation of gamma-aminobutyric acid aminotransferase by (S)-4-amino-4,5-dihydro-2-furancarboxylic acid does not proceed by the expected aromatization mechanism. (2004) (13)
- SAR studies of fluorine-substituted benzylamines and substituted 2-phenylethylamines as substrates and inactivators of monoamine oxidase B. (1995) (13)
- Observation of two different chromophores in the resting state of monoamine oxidase B by fluorescence spectroscopy. (1994) (13)
- Remote protection prevents unwanted cyclizations with 2-aminopyridines (2006) (12)
- Radical thoughts about the life of MAO. (1995) (12)
- A New Class of Conformationally Rigid Analogues of 4-Amino-5-halopentanoic Acids, Potent Inactivators of γ-Aminobutyric Acid Aminotransferase. (2000) (12)
- Mechanism of inactivation of gamma-aminobutyric acid aminotransferase by (S,E)-4-amino-5-fluoropent-2-enoic acid. (1988) (12)
- Design and Synthesis of Potent Quinazolines as Selective β-Glucocerebrosidase Modulators. (2016) (12)
- Mechanism of isomerization of a .beta.-keto sulfide (1981) (12)
- Improved synthesis of chiral pyrrolidine inhibitors and their binding properties to neuronal nitric oxide synthase. (2011) (12)
- Selective Targeting by a Mechanism-Based Inactivator against Pyridoxal 5'-Phosphate-Dependent Enzymes: Mechanisms of Inactivation and Alternative Turnover. (2017) (12)
- Mechanism of Inactivation of GABA Aminotransferase by (E)- and (Z)-(1S,3S)-3-Amino-4-fluoromethylenyl-1-cyclopentanoic Acid. (2015) (12)
- Effect of potential amine prodrugs of selective neuronal nitric oxide synthase inhibitors on blood-brain barrier penetration. (2009) (12)
- Probing the steric requirements of the γ-aminobutyric acid aminotransferase active site with fluorinated analogues of vigabatrin. (2013) (12)
- New analogues of N-(2-aminoethyl)-4-chlorobenzamide (Ro 16-6491). Some of the most potent monoamine oxidase-B inactivators. (1993) (12)
- Conversion of Quinazoline Modulators from Inhibitors to Activators of β-Glucocerebrosidase. (2019) (12)
- Chiral discrimination among aminotransferases: inactivation by 4-amino-4,5-dihydrothiophenecarboxylic acid. (2010) (12)
- Mechanism for reactivation of N-cyclopropylbenzylamine-inactivated monoamine oxidase by amines. (1985) (11)
- An Accessible Chiral Linker to Enhance Potency and Selectivity of Neuronal Nitric Oxide Synthase Inhibitors. (2014) (11)
- 4-(Aminomethyl)-1-aryl-2-pyrrolidinones, a new class of monoamine oxidase B inactivators. (1992) (11)
- Mechanism-Based Enzyme Inactivation via a Diactivated Cyclopropane Intermediate (1993) (11)
- Two continuous coupled assays for ornithine-δ-aminotransferase. (2013) (11)
- Inhibitor Bound Crystal Structures of Bacterial Nitric Oxide Synthase. (2015) (11)
- A Remarkable Difference That One Fluorine Atom Confers on the Mechanisms of Inactivation of Human Ornithine Aminotransferase by Two Cyclohexene Analogues of γ-Aminobutyric Acid. (2020) (11)
- An Improved Procedure for the Synthesis of Substituted -Hydroxynitriles (1998) (11)
- Acid-Facilitated Debenzylation of N-Boc, N-Benzyl Double Protected 2-Aminopyridinomethylpyrrolidine Derivatives. (2012) (11)
- 2-(Fluoromethyl)-3-phytyl-1,4-naphthoquinone and its 2,3-epoxide. Inhibition of vitamin K epoxide reductase. (1989) (10)
- The multiple active enzyme species of γ-aminobutyric acid aminotransferase are not isozymes (2000) (10)
- Purification and inactivation of 3-hydroxyanthranilic acid 3,4-dioxygenase from beef liver. (2003) (10)
- 1-Benzylcyclopropylamine and 1-(phenylcyclopropyl)methylamine: an inactivator and a substrate of monoamine oxidase. (1985) (10)
- Invivo inactivation of γ-aminobutyric acid-α-ketoglutarate transaminase by 4-amino-5-fluoropentanoic acid (1981) (10)
- Lead Discovery and Lead Modification (2015) (10)
- Inactivation of monoamine oxidase B by 1-phenylcyclopropylamine: mass spectral evidence for the flavin adduct. (2001) (10)
- N(omega)-Nitroarginine-containing dipeptide amides. Potent and highly selective inhibitors of neuronal nitric oxide synthase. (1999) (10)
- Chiral linkers to improve selectivity of double-headed neuronal nitric oxide synthase inhibitors. (2013) (10)
- Mechanism of Inactivation of Ornithine Aminotransferase by (1 S,3 S)-3-Amino-4-(hexafluoropropan-2-ylidenyl)cyclopentane-1-carboxylic Acid. (2019) (10)
- Synthesis of ( S)-3-Amino-4-(difluoromethylenyl)-cyclopent-1-ene-1-carboxylic Acid (OV329), a Potent Inactivator of γ-Aminobutyric Acid Aminotransferase. (2018) (10)
- Synthesis of arginine-containing hydroxamate dipeptidomimetics (2006) (9)
- Anomalous Schmidt reaction products of phenylacetic acid and derivatives (2000) (9)
- Inactivation of monoamine oxidase B by benzyl 1-(aminomethyl) cyclopropane-1-carboxylate. (1997) (9)
- Chapter 8 – Drug Metabolism (2014) (9)
- Mechanistic studies of inactivation of inducible nitric oxide synthase by amidines. (2015) (9)
- First Contact: 7-Phenyl-2-Aminoquinolines, Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors That Target an Isoform-Specific Aspartate. (2020) (9)
- A mechanism for substrate-Induced formation of 6-hydroxyflavin mononucleotide catalyzed by C30A trimethylamine dehydrogenase. (2003) (9)
- Synthesis of mevalonate- and fluorinated mevalonate prodrugs and their in vitro human plasma stability. (2015) (9)
- A Single Amino Acid Determines the Selectivity and Efficacy of Selective Negative Allosteric Modulators of CaV1.3 L-Type Calcium Channels. (2020) (9)
- β-Lactams: A New Class of Conformationally-Rigid Inhibitors of γ-Aminobutyric Acid Aminotransferase (1992) (9)
- Electron Transfer Chemistry of Monoamine Oxidase: Volume 2 (1992) (9)
- Concise route to the chiral pyrrolidine core of selective inhibitors of neuronal nitric oxide. (2009) (9)
- Inactivation of monoamine oxidase B by analogues of the anticonvulsant agent milacemide (2-(n-pentylamino)acetamide). (1993) (9)
- Drug Discovery, Design, and Development (2004) (9)
- Tertiary Amine Pyrazolones and Their Salts as Inhibitors of Mutant Superoxide Dismutase 1-Dependent Protein Aggregation for the Treatment of Amyotrophic Lateral Sclerosis. (2015) (9)
- Does the systolic pressure variation change in the prone position? (2009) (9)
- Deuteration and fluorination of 1,3-bis(2-phenylethyl)pyrimidine-2,4,6(1H,3H,5H)-trione to improve its pharmacokinetic properties. (2014) (9)
- Prodrugs and Drug Delivery Systems (2004) (8)
- N(ω)-Propargyl-L-arginine and N(ω)-hydroxy-N(ω)-propargyl-L-arginine are inhibitors, but not activators, of neuronal and macrophage nitric oxide synthases (1997) (8)
- Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with a Fluorobenzene Linker. (2017) (8)
- 2-(Iodoethenyl)benzylamines as Potential Probes for Radical Intermediates Formed during Monoamine Oxidase Catalyzed Oxidations. (1998) (8)
- (Aminoalkyl)trimethylgermanes, the first organogermanium mechanism-based enzyme inactivators: A new class of monoamine oxidase inactivators (1987) (8)
- Monoamine oxidase-catalyzed oxidative decarboxylation of cis- and trans-5-aminomethyl-3-(4-methoxyphenyl)dihydrofuran-2(3H)-one. Evidence for the intermediacy of an .alpha.-radical (1995) (7)
- In search of potent and selective inhibitors of neuronal nitric oxide synthase with more simple structures. (2013) (7)
- Chapter 6 – DNA-Interactive Agents (2014) (7)
- An Alkoxide Anion Triggered tert-Butyloxycarbonyl Group Migration. Mechanism and Application. (2010) (7)
- Monoamine oxidase-catalyzed amine oxidation in organic solvents (1995) (7)
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine analogues. Inactivation of monoamine oxidase by conformationally rigid analogues of N,N-dimethylcinnamylamine. (1988) (7)
- ENDOR spectroscopic evidence for the geometry of binding of retro-inverso-N(ω)-nitroarginine-containing dipeptide amides to neuronal nitric oxide synthase (2000) (7)
- 2,6‐Difluorophenol as a Bioisostere of a Carboxylic Acid: Bioisosteric Analogues of γ‐Aminobutyric Acid. (1999) (7)
- Solid-Phase Syntheses of Nω-Propylarginine-Containing Dipeptides, Dipeptide Esters, and Dipeptide Amides (1999) (7)
- Recent advances toward improving the bioavailability of neuronal nitric oxide synthase inhibitors. (2013) (7)
- Design and Evaluation of 3-(Benzylthio)benzamide Derivatives as Potent and Selective SIRT2 Inhibitors. (2015) (7)
- Combination of chiral linkers with thiophenecarboximidamide heads to improve the selectivity of inhibitors of neuronal nitric oxide synthase. (2014) (7)
- Mechanisms of Inactivation of γ-Aminobutyric Acid Aminotransferase by the Antiepilepsy Drug γ-Vinyl GABA ( Vigabatrin). (1992) (7)
- Synthesis of N-Carbobenzoxy-N,N-acetals (1993) (6)
- Poly(ethylene glycol)-supported enzyme inactivators. Efficient identification of the site of covalent attachment to alpha-chymotrypsin by PEG-TPCK. (2004) (6)
- Treatment of amyotrophic lateral sclerosis: lessons learned from many failures. (2014) (6)
- Hydroxyl-terminated peptidomimetic inhibitors of neuronal nitric oxide synthase. (2006) (6)
- Synthesis of (S)-2-Boc-Amino-8-(R)-(tert-butyldimethylsilanyloxy) decanoic acid, a Precursor to the Unusual Amino Acid Residue of the Anticancer Agent Microsporin B. (2011) (6)
- Physiological involvement of presynaptic L‐type voltage‐dependent calcium channels in GABA release of cerebellar molecular layer interneurons (2020) (6)
- Hydroxyethylene isosteres of selective neuronal nitric oxide synthase inhibitors. (2007) (6)
- CHAPTER 7: – Drug Metabolism (1992) (6)
- Synthesis of a series of 3,4-methanoarginines as side-chain conformationally restricted analogues of arginine. (2011) (6)
- A novel synthesis of 1-aryl-3-piperidone derivatives. (2013) (6)
- An Efficient Synthesis of 3-Amino-4-Fluorobutanoic Acid, an Inactivator of GABA Transaminase (1985) (6)
- Substrate stereospecificity and active site topography of gamma-aminobutyric acid aminotransferase for beta-aryl-gamma-aminobutyric acid analogues. (1987) (6)
- In vitro and in vivo effects on brain GABA metabolism of (S)-4-amino-5-fluoropentanoic acid, a mechanism-based inactivator of gamma-aminobutyric acid transaminase. (1983) (6)
- CHAPTER 5: – Enzyme Inhibition and Inactivation (1992) (6)
- Solubilization, Partial Purification, Mechanism, and Inactivation of Vitamin K Epoxide Reductase (1988) (5)
- Mechanism of inactivation of Escherichia coli aspartate aminotransferase by (S)-4-amino-4,5-dihydro-2-furancarboxylic acid . (2010) (5)
- Inactivation of γ-aminobutyric acid aminotransferase by l-3-chloroalanine hydroxamate (1995) (5)
- Direct amination of γ-halo-β-ketoesters with anilines. (2012) (5)
- Mechanism of inactivation of gamma-cystathionase by beta,beta,beta-trifluoroalanine. (1977) (5)
- Monoamine oxidase-catalyzed oxidation of endo,endo-2-amino-6-[(Z)-2'-phenyl]ethenylbicyclo[2.2.1]heptane, a potential probe for a radical cation intermediate. (2000) (5)
- Selective inactivation of monoamine oxidase B by aminoethyl 3-chlorobenzyl ether (1993) (5)
- Inactivation of γ-Aminobutyric Acid Aminotransferase by Various Amine Buffers (1992) (5)
- Deuterium isotope effects and product studies for the oxidation of N(ω)-allyl-L-arginine and N(ω)-allyl-N(ω)-hydroxy-L-arginine by neuronal nitric oxide synthase (2000) (5)
- Substituted vitamin K epoxide analogues. New competitive inhibitors and substrates of vitamin K1 epoxide reductase. (1990) (5)
- Syntheses of N‐[1‐2H]‐ and N‐[1‐3H]‐cyclopropylbenzylamine and [phenyl‐14C]‐N‐cyclopropylbenzylamine (1981) (5)
- Synthesis of Cyclopropane Isosteres of the Antiepilepsy Drug Vigabatrin and Evaluation of their Inhibition of GABA Aminotransferase (2004) (5)
- α-Amino acid analogues as mechanism-based inactivators of γ-aminobutyric acid aminotransferase (1992) (5)
- Structural Basis for Isoform Selective Nitric Oxide Synthase Inhibition by Thiophene-2-carboximidamides. (2018) (5)
- Mechanism-Based Design of 3-Amino-4-Halocyclopentenecarboxylic Acids as Inactivators of GABA Aminotransferase. (2020) (5)
- CHAPTER 2: – Drug Discovery, Design, and Development (1992) (5)
- 4-Amino-2-(substituted methyl)-2-butenoic Acids: Substrates and Potent Inhibitors of γ-Aminobutyric Acid Aminotransferase. (1986) (5)
- Time-dependent inhibition of neuronal nitric oxide synthase by N-propargylguanidine (1997) (5)
- The multiple active enzyme species of gamma-aminobutyric acid aminotransferase are not isozymes. (2000) (5)
- ALKYLATION OF THE DIMETHYLGLYOXIMATO LIGANDS IN REDUCED COBALOXIME (1976) (4)
- Theoretical and Mechanistic Validation of Global Kinetic Parameters of the Inactivation of GABA Aminotransferase by OV329 and CPP-115. (2021) (4)
- Turnover and Inactivation Mechanisms for (S)-3-Amino-4,4-difluorocyclopent-1-enecarboxylic Acid, a Selective Mechanism-Based Inactivator of Human Ornithine Aminotransferase. (2021) (4)
- SYNTHESES OF (S)-5-SUBSTITUTED 4-AMINOPENTANOIC ACIDS: A NEW CLASS OF Γ-AMINOBUTYRIC ACID TRANSAMINASE INACTIVATORS (1980) (4)
- Remarkable and Unexpected Mechanism for (S)-3-Amino-4-(difluoromethylenyl)cyclohex-1-ene-1-carboxylic Acid as a Selective Inactivator of Human Ornithine Aminotransferase. (2021) (4)
- Mechanism-Based Enzyme Inactivators for Medical Uses (1986) (4)
- OV329, a novel highly potent γ‐aminobutyric acid aminotransferase inactivator, induces pronounced anticonvulsant effects in the pentylenetetrazole seizure threshold test and in amygdala‐kindled rats (2021) (4)
- Mild and Selective Sodium Azide Mediated Cleavage of p‐Nitrobenzoic Esters. (2001) (4)
- Synthesis and Evaluation of Dipeptide Amides Containing Nω-Nitroarginine and D-2, 4-Diaminobutyric Acids as Inhibitors of Neuronal Nitric Oxide Synthase (2001) (4)
- Structural and Kinetic Analyses Reveal the Dual Inhibition Modes of Ornithine Aminotransferase by (1S,3S)-3-Amino-4-(hexafluoropropan-2-ylidenyl)-cyclopentane-1-carboxylic Acid (BCF3). (2020) (4)
- Slow-binding inhibition of gamma-aminobutyric acid aminotransferase by hydrazine analogues. (1996) (4)
- Synthesis of 2-Substituted-3-phytyl-1,4-naphthoquinone Epoxides (1990) (3)
- High yielding allylation of a chiral secondary alcohol containing base sensitive functional groups. (2012) (3)
- Synthesis and evaluation of dipeptide amides containing N omega-nitroarginine and D-2,4-diaminobutyric acids as inhibitors of neuronal nitric oxide synthase. (2001) (3)
- Mechanism-based inactivation of gamma-aminobutyric acid aminotransferase by 3-amino-4-fluorobutanoic acid. (1996) (3)
- Oxazolidinones, dihydrofuranones, and pyrrolidinones as inactivators and substrates of monoamine oxidase B: approaches to the design of antiparkinsonian agents. (1997) (3)
- Inactivation of C30A trimethylamine dehydrogenase by N-cyclopropyl-alpha-methylbenzylamine, 1-phenylcyclopropylamine, and phenylhydrazine. (2001) (3)
- Monoamine Oxidase B-Catalyzed Reactions of cis- and trans-5-Aminomethyl-3-(4-Methoxyphenyl)dihydrofuran-2(3H)-ones. Evidence for a Reversible Redox Reaction (1998) (3)
- Positioning for Neurosurgery (2013) (3)
- Erratum: Mechanism of inactivation of γ-aminobutyric acid-α-ketoglutaric acid aminotransferase by 4-amino-5-halopentanoic acids (Biochemistry (1981) 20:5 (1197-1203)) (1981) (3)
- Thin-Layer Chromatography of Acid-Labile Cobalamins (1980) (3)
- Mechanism of Inactivation of γ-Aminobutyric Acid Aminotransferase by 4-Amino-5-hexynoic Acid (γ-Ethynyl GABA). (1992) (3)
- Effect of N-ethylmaleimide on beef and rat liver vitamin K1 epoxide reductase. (1990) (3)
- NU-9 improves health of hSOD1G93A mouse upper motor neurons in vitro, especially in combination with riluzole or edaravone (2022) (3)
- Mechanism of Inactivation of Neuronal Nitric Oxide Synthase by (S)-2-Amino-5-(2-(methylthio)acetimidamido)pentanoic Acid. (2015) (3)
- Action of hydrogen sulfide on aminoalkanethiosulfuric acids (Bunte salts) to give di-, tri-, and tetrasulfides (1971) (3)
- The oxidation of tungsten carbonyl in carbon tetrachloride (1968) (3)
- Aminomethyl-2,6-difluorophenols as a novel class of increased lipophilicity GABA(C) receptor antagonists. (1999) (3)
- Inactivation of monoamine oxidase by 3,3-dimethyl analogues of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 1-methyl-4-phenyl-2,3-dihydropyridinium ion. Dramatic effect of beta-mercaptoethanol on substrate turnover and enzyme inactivation. (1989) (3)
- Beta-lactams: a new class of conformationally-rigid inhibitors of gamma-aminobutyric acid aminotransferase. (1992) (3)
- CHAPTER 3: – Receptors (1992) (3)
- CHAPTER 6: – DNA (1992) (3)
- Time-dependent inhibition of γ-aminobutyric acid aminotransferase, by 3-hydroxybenzylhydrazine (1995) (3)
- Effect of the locus of the oxygen atom in amino ethers on the inactivation of monoamine oxidase B. (1998) (3)
- Inhibition of interferon-gamma-stimulated melanoma progression by targeting neuronal nitric oxide synthase (nNOS) (2022) (3)
- Inactivators of Ornithine Aminotransferase for the Treatment of Hepatocellular Carcinoma. (2021) (3)
- Basic science to blockbuster drug: invention of pregabalin (Lyrica®) (2016) (3)
- Pregabalin Treatment does not Affect Amyloid Pathology in 5XFAD Mice (2021) (3)
- Reaction of Diethyl Acetonedicarboxylate with Nitrosyl Chloride (1978) (2)
- Tapentadol extended-release: a recent addition to our analgesic armamentarium. (2012) (2)
- Monoamine Oxidase-Catalyzed Oxidative Rearrangement of trans,trans-1-(Aminomethyl)-2-methoxy-3-phenylcyclopropane. (1996) (2)
- Mechanism for the reaction of trans 2 phenylcyclopropylamine with nitrous acid (1984) (2)
- Case study 3: Fragment hopping to design highly potent and selective neuronal nitric oxide synthase inhibitors (2013) (2)
- 4-(Oxoalkyl)-substituted GABA analogues as inactivators and substrates of GABA aminotransferase. (1991) (2)
- Correction - Mechanism of Inactivation of γ-Aminobutyric Acid -α-Ketoglutaric Acid Aminotransferase by 4-Amino-5-halopentanoic Acids (1981) (2)
- Syntheses of amino nitrones. Potential intramolecular traps for radical intermediates in monoamine oxidase-catalyzed reactions. (1998) (2)
- N omega-propargyl-L-arginine and N omega-hydroxy-N omega-propargyl-L-arginine are inhibitors, but not inactivators, of neuronal and macrophage nitric oxide synthases. (1997) (2)
- Rational Design, Synthesis, and Mechanism of (3S,4R)-3-Amino-4-(difluoromethyl)cyclopent-1-ene-1-carboxylic Acid: Employing a Second-Deprotonation Strategy for Selectivity of Human Ornithine Aminotransferase over GABA Aminotransferase. (2022) (2)
- Abstracts, Division of Biological Chemistry, 222nd National Meeting of the American Chemical Society, August 26−29, 2001 (2001) (2)
- CHAPTER 8: – Prodrugs and Drug Delivery Systems (1992) (2)
- Chapter 9 – Prodrugs and Drug Delivery Systems (2014) (2)
- Mechanism of Inactivation of Monoamine Oxidase by N-Cyclopropyl-N-Arylalkyl Amines (1979) (2)
- Inactivation of γ-aminobutyric acid aminotransferase by (Z)-4-amino-6-fluoro-5-hexenoic acid: Identification of an active site residue (1996) (2)
- Structure of the ornithine aminotransferase from Toxoplasma gondii crystallized in presence of oxidized glutathione reveals partial occupancy of PLP at the protein active site (2016) (2)
- SANSALVAMIDE ANALOG INDUCES G1 CELL-CYCLE ARREST THROUGH UP REGULATION OF P21 AND DOWN REGULATION OF CDK4 AND CYCLIN E IN PANCREATIC CANCER CELLS (2008) (2)
- Cobalamins and Cobinamides (2007) (2)
- Palladium-Catalyzed α-Arylation of Cyclic β-Dicarbonyl Compounds for the Synthesis of CaV1.3 Inhibitors (2022) (2)
- and are inhibitors, but not inactivators, of neuronal and macrophage nitric oxide synthases (1997) (1)
- Solid-Phase Synthesis of Peptides, Peptidomimetics, and Cyclic Peptides Using Traceless Aromatic Side-Chain Tethered Building Blocks (2000) (1)
- Unliganded structure of the ornithine aminotransferase from Toxoplasma gondii (2015) (1)
- Correction to A Single Amino Acid Determines the Selectivity and Efficacy of Selective Negative Allosteric Modulators of CaV1.3 L-Type Calcium Channels. (2021) (1)
- Deuterium isotope effects and product studies for the oxidation of N(omega)-allyl-L-arginine and N(omega)-allyl-N(omega)-hydroxy-L-arginine by neuronal nitric oxide synthase. (2000) (1)
- Correction to Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with a Fluorobenzene Linker. (2018) (1)
- Thiophene-2-carboximidamide Based Selective Neuronal Nitric Synthase Oxide Inhibitors (2014) (1)
- PANCREATIC CANCER CELL CYCLE ARREST AND APOPTOSIS ARE INDUCED BY A NOVEL DEPSIPEPTIDE SANSALVAMIDE ANALOGUE (2005) (1)
- Chapter 4 – Enzymes (2004) (1)
- Erratum: Unexpected binding modes of nitric oxide synthase inhibitors effective in the prevention of a cerebral palsy phenotype in an animal model (Journal of the American Chemical Society (2010) 132 (5437-5442)) (2010) (1)
- Inactivation of γ-Aminobutyric Acid Aminotransferase by (S,E)-4-Amino- 5-fluoropent-2-enoic Acid and Effect on the Enzyme of (E)-3-(1-Aminocy- clopropyl)-2-propenoic Acid. (1987) (1)
- Do Anesthesia Residents perceive a Benefit from participating in Bedside Tracheostomies? (2014) (1)
- Successful ICU Care of a 14-Year-Old With Total Artificial Circulation Using Two Ventricular Assist Devices for 118 Days (2012) (1)
- Chapter 5 – Enzyme Inhibition and Inactivation (2014) (1)
- Monoamine Oxidase-Catalyzed Amine Oxidation in Organic Solvents. (2010) (1)
- Drug Resistance and Drug Synergism (2015) (1)
- Correction to Phenyl Ether- and Aniline-Containing 2-Aminoquinolines as Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase. (2016) (1)
- Irreversible inactivation of pig brain gamma-aminobutyric acid-alpha-ketoglutarate transaminase by 4-amino-5-halopentanoic acids. (1980) (1)
- Erratum: Substituted pyrazolones require N2 hydrogen bond donating ability to protect against cytotoxicity from protein aggregation of mutant superoxide dismutase 1 (Bioorganic and Medicinal Chemistry Letters (2012) 22 (6647-6650)) (2014) (1)
- MECHANISM OF ISOMERIZATION OF A β-KETO SULFIDE (1982) (1)
- Model studies for heme oxygenase-catalyzed porphyrin meso hydroxylation. (2007) (1)
- Continuation of Extracorporeal Membrane Oxygenation Support After Multiple Failed Lung Transplantations (2012) (1)
- 1 1 2 Regulation of aldosterone secretion by Cav 1 . 3 3 (2016) (1)
- Crystal structure of the ornithine aminotransferase from Toxoplasma gondii ME49 in a complex with (S)-4-amino-5-fluoropentanoic acid (2016) (1)
- ESR Studies of Monoamine Oxidase B. First Direct Evidence for a Substrate Radical Intermediate. (1989) (1)
- Inactivation of gamma-aminobutyric acid aminotransferase by L-3-chloroalanine hydroxamate. (1995) (1)
- GABA-aminotransferase inactivated by conformationally-restricted inactivator (2016) (1)
- Design and of Monoamine Oxidase Inactivators from a Chemical Perspective (1993) (1)
- In vivo inactivation of gamma-aminobutyric acid-alpha-ketoglutarate transaminase by 4-amino-5-fluoropentanoic acid. (1981) (1)
- The oxazolidinone antibacterial agent DuP 105 does not act on cell wall biosynthesis or on a beta-lactamase. (1993) (1)
- Correction to “Temperature-Dependent Spin Crossover in Neuronal Nitric Oxide Synthase Bound with the Heme-Coordinating Thioether Inhibitors” (2013) (1)
- Inactivation of gamma-aminobutyric acid aminotransferase by various amine buffers. (1992) (1)
- Paper chromatographic and electrophoretic separations of orotic acid, 5-fluoroorotic acid, 5-fluorouracil, and 5-fluorouridine 5'-monophosphate (1978) (1)
- Aminomethyl-2,6-difluorophenols as a Novel Class of Increased Lipophilicity GABAc Receptor Antagonists. (2000) (1)
- Synthesis of [carboxyl ‐14C] 5 ‐ fluoroorotic acid (1979) (1)
- Objection to terminology used in special report [1] (1983) (1)
- Structures of GABA Aminotransferase, a Pyridoxal 5'-Phosphate and [2Fe-2S] Cluster Containing Enzyme, Complexed with g -EthynylGABA and with the Antiepilepsy Drug Vigabatrin (2003) (1)
- Correction to Conversion of Quinazoline Modulators from Inhibitors to Activators of β-Glucocerebrosidase. (2019) (1)
- Anesthesia Preoperative Evaluation ClinicIV (1997) (1)
- CHAPTER 4: – Enzymes (Catalytic Receptors) (1992) (1)
- DNA-Interactive Agents (2004) (1)
- Fluorinated conformationally restricted gamma-aminobutyric acid aminotransferase inhibitors. (2006) (1)
- Enzyme Inhibition: Approaches to Drug Design: 4th SCI-RSC Medicinal Chemistry Symposium (1988) (0)
- Bovine eNOS N368D/V106M double mutant with L-N(omega)-Nitroarginine-(4R)-Amino-L-Proline Amide Bound (2005) (0)
- Selective inhibition of monoamine oxidase B by aminoethyl substituted benzyl ethers. (2000) (0)
- Bovine endothelial NOS heme domain with L-N(omega)-nitroarginine-(4R)-amino-L-proline amide bound (2004) (0)
- Rat neuronal NOS heme domain with L-N(omega)-nitroarginine-(4R)-amino-L-proline amide bound (2004) (0)
- ENDOR Studies of l-Arginine and NG-Hydroxy-l-Arginine Bound to All Three Holo-Nitric Oxide Synthase Isozymes [J. Am. Chem. Soc. 2000, 122, 5405−5406]. (2000) (0)
- Rat neuronal NOS D597N mutant heme domain with L-N(omega)-nitroarginine-2,4-L-diaminobutyric amide bound (2004) (0)
- Anesthesia preoperative evaluation clinic. (1997) (0)
- Mechanism of hydrolysis of .beta.-acetal cobalamins (1975) (0)
- O69. Prevention of cerebral palsy with de novo designed neuronal nitric oxide synthase selective inhibitors (2008) (0)
- Ornithine aminotransferase inactivated by (1R,3S,4S)-3-amino-4-fluorocyclopentane-1-carboxylic acid (FCP) (2017) (0)
- 5‐(Aminomethyl)‐3‐aryl‐2‐oxazolidinones. A Novel Class of Mechanism‐ Based Inactivators of Monoamine Oxidase B. (2010) (0)
- The Enantiomers of 4-Amino-3-fluorobutanoic Acid as Substrates for γ -Aminobutyric Acid Aminotransferase. Conformational Probes for GABA Binding (2008) (0)
- Crystal structure of the ornithine aminotransferase from Toxoplasma gondii ME49 in a complex with gabaculine (2016) (0)
- 2.3 A resolution crystal structure of the ornithine aminotransferase from Toxoplasma gondii ME49 (2015) (0)
- Correction to Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2-Aminoquinoline Inhibitors. (2019) (0)
- Identifi cation of compounds protective against G 93 A-SOD 1 toxicity for the treatment of amyotrophic lateral sclerosis (2010) (0)
- THE ORGANIC CHEMISTRY OF MECHANISM-BASED ENZYME INHIBITION: A CHEMICAL APPROACH TO DRUG DESIGN (1984) (0)
- Time-dependent inhibition of gamma-aminobutyric acid aminotransferase, by 3-hydroxybenzylhydrazine. (1995) (0)
- Rat nNOS D597N mutant with L-N(omega)-Nitroarginine-(4R)-amino-L-proline amide bound (2005) (0)
- Synthesis of 2-Substituted 3-Phytyl-1,4-naphthoquinone Epoxides. (1990) (0)
- Bovine endothelial NOS heme domain with (4S)-N-(4-amino-5-[aminoethyl]aminopentyl)-N'-nitroguanidine bound (2004) (0)
- Inhibition of interferon-gamma-stimulated melanoma progression by targeting neuronal nitric oxide synthase (nNOS) (2022) (0)
- Involvement of P21/WAF1 and cyclin E in induction of pancreatic cancer cell G0/G1 arrest and apoptosis by a novel peptide sansalvamide analogue (2005) (0)
- Structure of the ornithine aminotransferase from Toxoplasma gondii in complex with inactivator (2016) (0)
- Selective Neural Nitric Oxide Synthase Inhibitors (2004) (0)
- (S)‐4‐Amino‐5‐phenoxypentanoate designed as a potential selective agonist of the bacterial transcription factor GabR (2020) (0)
- Rat nNOS D597N/M336V double mutant with L-N(omega)-Nitroarginine-2,4-L-Diaminobutyric Amide Bound (2005) (0)
- ANESTHESIA PREOPERATIVE EVALUATION CLINIC : IV. AUTHORS' REPLY (1997) (0)
- The anti-ulcer drug ranitidine hydrochloride and its synthetic intermediates are inactivators of monoamine oxidase-B. (1993) (0)
- Erratum: Imidazole-containing amino acids as selective inhibitors of nitric oxide synthases (Bioorg. Med. Chem. (1999) 7 (1941-1951) PII: S0968089699001170) (2000) (0)
- Design of Potential Anticonvulsant Agents: Mechanistic Classification of y-Aminobutyric Acid Aminotransferase Inactivators (1989) (0)
- Neuronal Nitric Oxide Synthase (nNOS)/NO, An Accelerator of Melanoma Progression, is a Potential Target for Chemoprevention (2011) (0)
- (1S,3S)-3-amino-4-(perfluoropropan-2-ylidene)cyclopentane-1-carboxylic acid hydrochloride, a potent inhibitor of ornithine aminotransferase (2019) (0)
- Letter: Formylmethylcobalamin. (1974) (0)
- Correction to "Rational Design, Synthesis, and Mechanism of (3S,4R)-3-Amino-4-(difluoromethyl)cyclopent-1-ene-1-carboxylic Acid: Employing a Second-Deprotonation Strategy for Selectivity of Human Ornithine Aminotransferase over GABA Aminotransferase". (2023) (0)
- Traceless solid-phase synthesis of chiral 3-aryl beta-amino acid containing peptides using a side-chain-tethered beta-amino acid building block. (2000) (0)
- Bovine endothelial nitric oxide synthase N368D mutant heme domain dimer with L-N(omega)-nitroarginine-2,4-L-diaminobutyramide bound (2004) (0)
- GABA and L-glutamic attack against reading (1994) (0)
- Miscellaneous Selenium-Containing Heterocycles (1973) (0)
- MECHANISM OF INACTIVATION OF GAMMA -AMINOBUTYRIC ACID AMINOTRANSFERASE BY 3-HYDRAZINOPROPIONIC ACID (1995) (0)
- Supplementary Material for: Involvement of Neuronal Nitric Oxide Synthase in Ongoing Fetal Brain Injury following Near-Term Rabbit Hypoxia-Ischemia (2017) (0)
- Chemoenzymatic Synthesis of (R)- and (S)-4-Amino-3-methylbutanoic Acids. (1990) (0)
- Mechanism-based inactivation of monoamine oxidase by 1-phenylcyclopropylamine (1985) (0)
- 2-Aminopyridines with a shortened amino sidechain as potent, selective, and highly permeable human neuronal nitric oxide synthase inhibitors. (2022) (0)
- Structural and Mechanistic Basis for the Inactivation of Human Ornithine Aminotransferase by (3S,4S)-3-Amino-4-fluorocyclopentenecarboxylic Acid (2023) (0)
- Rat nNOS D597N/M336V double mutant with L-N(omega)-Nitroarginine-(4R)-amino-L-proline amide bound (2005) (0)
- Drug Discovery: Ingenuity and Serendipity...Or is It the Other Way Around? (2020) (0)
- Formylsilanes. Chemoenzymatic and Chemical Syntheses of the 2,4- Dinitrophenylhydrazones of These Apparently Air- and Water-Stable Compounds. (1993) (0)
- Corrigendum to “Imidazole-containing amino acids as selective inhibitors of nitric oxide synthases” (2000) (0)
- Synthesis of N‐Carbobenzoxy‐N,N‐acetals. (1994) (0)
- Rat neuronal NOS heme domain with L-N(omega)-nitroarginine-2,4-L-diaminobutyric amide bound (2004) (0)
- Hydrolysis of y-Acetal Cobaloximes (1975) (0)
- Inhibition studies of 3-hydroxyanthranilic acid oxygenase from beef liver (1997) (0)
- GABA and L-glutamic acid to anti-seizure treatment (1993) (0)
- MECHANISM FOR THE REACTION OF TRANS-2-PHENYLCYCLOPROPYLAMINE WITH NITROUS ACID (1985) (0)
- Complex Structure of D-Amino Acid Aminotransferase and 4-amino-4,5-dihydro-thiophenecarboxylic acid (ADTA) (2010) (0)
- Correction to "Chiral Cyclohexane 1,3-Diones as Inhibitors of Mutant SOD1-Dependent Protein Aggregation for the Treatment of ALS". (2017) (0)
- Selenium Analogs of Aldehydes and Ketones (1973) (0)
- Bovine eNOS N368D single mutant with L-N(omega)-Nitroarginine-(4R)-Amino-L-Proline Amide Bound (2005) (0)
- Faculty Opinions recommendation of Sugar-assisted ligation in glycoprotein synthesis. (2007) (0)
- Digital Imaging Technology in Trauma Education: A Quantum Leap Forward (1999) (0)
- Bovine endothelial NOS heme domain with D-phenylalanine-D-nitroarginine amide bound (2004) (0)
- Potent and Highly Selective Heteraromatic Inhibitors of Neuronal Nitric Oxide Synthase (2008) (0)
- Nitric Oxide Synthase as a Target for Methicillin-Resistant Staphylococcus aureus Graphical (2015) (0)
- Mechanism of Inactivation of Mitochondrial Monoamine Oxidase by Cyclopropylamines (1979) (0)
- Structure of endothelial nitric oxide synthase heme domain complexed with 6-{{(3'R,4'R)-3'-[2""-(3'''-fluorophenethylamino)ethoxy]pyrrolidin-4'-yl}methyl}-4-methylpyridin-2-amine (2010) (0)
- Structural and biological characterization of NOS inhibitors with antimicrobial properties (585.5) (2014) (0)
- REACTIONS OF VINYL ETHERS WITH COBALAMINS AND COBALOXIMS (1975) (0)
- Crystal structure of the ornithine aminotransferase from Toxoplasma gondii ME49 in a complex with the Schiff base between PLP and Lys286 (2015) (0)
- Erratum: Corrigendum to 'Inactivation of monoamine oxidase B by benzyl 1-(aminomethyl)cyclopropane-l-carboxylate' (Bioorganic and Medicinal Chemistry (1997) 5 (297)) (1998) (0)
- Microsporins A (Ia) and B (Ib): New Histone Deacetylase Inhibitors from the Marine-Derived Fungus Microsporum cf. gypseum and the Solid-Phase Synthesis of Microsporin A. (2007) (0)
- Crystal structure of glucocerebrosidase with an inhibitory quinazoline modulator (2017) (0)
- Rat neuronal NOS heme domain with D-lysine-D-nitroarginine amide bound (2004) (0)
- Faculty Opinions recommendation of Identification of oxadiazoles as new drug leads for the control of schistosomiasis. (2008) (0)
- Use of Ultrasound to Identify Pretracheal Vasculature Prior to Percutaneous Dilatational Tracheostomy (2010) (0)
- Correction to Selective Targeting by a Mechanism-Based Inactivator against Pyridoxal 5'-Phosphate-Dependent Enzymes: Mechanisms of Inactivation and Alternative Turnover. (2017) (0)
- Administration of Tissue Plasminogen Activator (tPA) during an Orthotopic Heart Transplant (2009) (0)
- GABA analogs and L-glutamic for the treatment of disorders of CNS acid. (1993) (0)
- 1P157 Exploring the Binding Conformations of Bulkier Dipeptide Amide Inhibitors in Constitutive Nitric Oxide Synthases(5. Heme protein,Poster Session,Abstract,Meeting Program of EABS & BSJ 2006) (2006) (0)
- Cardiac Concepts in Acute Care (2009) (0)
- Gaba and l-glutaminsaüre analogues in the treatment of epilepsy (1993) (0)
- A novel sansalvamide analogue inhibits pancreatic cancer cell proliferation via induction of macrophage inhibitory cytokine (MIC-1) (2006) (0)
- E.coli Aspartate aminotransferase-(1R,3S,4S)-3-amino-4-fluorocyclopentane-1-carboxylic acid (FCP)-alpha-ketoglutarate (2017) (0)
- Bovine endothelial NOS heme domain with L-N(omega)-nitroarginine-2,4-L-diaminobutyric amide bound (2004) (0)
- Structural and Kinetic Analyses Reveal the Dual Inhibition Modes of Ornithine Aminotransferase by (1 S ,3 S )-3-Amino-4 (Hexafluoropropan-2-Ylidenyl)-Cyclopentane-1-Carboxylic Acid (BCF 3 ) (2021) (0)
- Protein Aggregation Inhibitors for ALS Therapy (2013) (0)
- GABA and L-scene anti-reading glutamiinihappoanalogit (1994) (0)
- Structural Studies Reveal The Inactivation of E. coli L-aspartate aminotransferase by (S)-4,5-amino-dihydro-2-thiophenecarboxylic acid (SADTA) via Two Mechanisms (at pH 8.0) (2007) (0)
- Selective Neuronal Nitric Oxide Synthase Inhibitors: Volume 4 (2009) (0)
- Remote Protection Prevents Unwanted Cyclizations with 2-Aminopyridines. (2006) (0)
- Mechanism of inactivation of E. coli aspartate aminotransferase by (S)-4-amino-4,5-dihydro-2-furancarboxylic acid (S-ADFA) pH 8.0 (2010) (0)
- Bovine endothelial NOS heme domain with D-lysine-D-nitroarginine amide bound (2004) (0)
- A Convenient Synthesis of 3-Alkyl-4-aminobutanoic Acids. (1990) (0)
- Use (1s,3s)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid as a gaba aminotransferse inhibitor (2011) (0)
- Irreversible inhibition of ornithine aminotransferase mediates hepatocellular carcinoma suppression is a result of inhibition of glutamine and beta-catenin and suppression of regulatory T cells: a novel mechanism for treatment of primary liver cancer (2017) (0)
- Rat neuronal NOS heme domain with D-phenylalanine-D-nitroarginine amide bound (2004) (0)
- Searching for gamma-aminobutyric acid aminotransferase inhibitors A synthetic and computational approach (2001) (0)
- Rat neuronal NOS heme domain with (4S)-N-(4-amino-5-[aminoethyl]aminopentyl)-N'-nitroguanidine bound (2004) (0)
- Design, Synthesis, and Mechanism of Fluorine-substituted Cyclohexene Analogues of GAMA-Aminobutyric Acid (GABA) as Selective Ornithine Aminotransferase Inactivators (2020) (0)
- The crystal structure of human ornithine aminotransferase with an intermediate bound during inactivation by (1S,3S)-3-amino-4-(hexafluoropropan-2-ylidenyl)-cyclopentane-1-carboxylic acid. (2021) (0)
- The mechanism of action of coenzyme B12 (1979) (0)
- Inactivation of monoamine oxidase B by cis- and trans-5-aminomethyl-3-(4-methoxyphenyl)dihydrofuran-2(3H)-ones. (1998) (0)
- 1H‐Pyrazole‐1‐carboxamidines: New Inhibitors of Nitric Oxide Synthase. (2001) (0)
- Faculty Opinions recommendation of High-throughput log P determination by ultraperformance liquid chromatography: a convenient tool for medicinal chemists. (2008) (0)
- Separation and characterization of multiactivity peaks of 3-hydroxyanthranilic acid oxygenase from bovine liver (1998) (0)
- Crystal Structure of GABA Aminotransferase bound to (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid, an Potent Inactivatorfor the Treatment of Addiction (2018) (0)
- A Small Peptide Increases Drug Delivery in Human Melanoma Cells (2022) (0)
- Pig Brain GABA-AT inactivated by (E)-(1S,3S)-3-Amino-4-fluoromethylenyl-1-cyclopentanoic acid (2015) (0)
- 3-substituted alanines inactivate γ-aminobutyric acid aminotransferase by the same mechanism as do 4-amino-5-halopentanoic acid analogues (1996) (0)
This paper list is powered by the following services:
Other Resources About Richard Bruce Silverman
What Schools Are Affiliated With Richard Bruce Silverman?
Richard Bruce Silverman is affiliated with the following schools:
