Richard A. Flavell

Richard A. Flavell's AcademicInfluence.com Rankings

Richard A. Flavell

Biology

#745

World Rank

#1293

Historical Rank

Biochemistry

#49

World Rank

#64

Historical Rank

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Biology

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According to Wikipedia, Richard Anthony Flavell , PhD, FRS is an English molecular biologist, and Sterling Professor of Immunobiology, at Yale School of Medicine where he uses transgenic and gene-targeted mice to study Innate and Adaptive immunity, T cell tolerance and activation in immunity and autoimmunity, apoptosis, and regulation of T cell differentiation. He is an investigator at the Howard Hughes Medical Institute. In 2013, Flavell received the Vilcek Prize in Biomedical Science. In July 2016, Flavell received an honorary doctorate degree from the University of Hull. He is an honorary member of the British Society for Immunology.

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Richard A. Flavell's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3 (2001) (6169)
The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells (1997) (2508)
Help for cytotoxic-T-cell responses is mediated by CD40 signalling (1998) (2441)
Transforming growth factor-beta regulation of immune responses. (2006) (2092)
Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway (2000) (2032)
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity (2012) (2001)
Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice (1996) (1969)
Recognition of single-stranded RNA viruses by Toll-like receptor 7. (2004) (1876)
Inflammasomes in health and disease (2012) (1873)
Nod2-Dependent Regulation of Innate and Adaptive Immunity in the Intestinal Tract (2005) (1850)
Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway. (2000) (1798)
Reduced Apoptosis and Cytochrome c–Mediated Caspase Activation in Mice Lacking Caspase 9 (1998) (1710)
BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis. (2001) (1707)
Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme. (1995) (1702)
MAP kinases in the immune response. (2002) (1702)
NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis (2011) (1702)
CD40 and CD154 in cell-mediated immunity. (1998) (1688)
Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants (2008) (1489)
Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms (2013) (1448)
Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene (1997) (1282)
IRAK-M Is a Negative Regulator of Toll-like Receptor Signaling (2002) (1191)
Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus. (2006) (1175)
Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis (2004) (1131)
Caspases 3 and 7: Key Mediators of Mitochondrial Events of Apoptosis (2006) (1070)
Natural regulatory T cells control the development of atherosclerosis in mice (2006) (1033)
TLR11 Activation of Dendritic Cells by a Protozoan Profilin-Like Protein (2005) (1033)
Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus. (2006) (1022)
Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection. (2004) (1021)
ICOS co-stimulatory receptor is essential for T-cell activation and function (2001) (979)
Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1. (2006) (962)
Instruction of Distinct CD4 T Helper Cell Fates by Different Notch Ligands on Antigen-Presenting Cells (2004) (943)
Activation of Interferon-γ Inducing Factor Mediated by Interleukin-1β Converting Enzyme (1997) (942)
Abrogation of TGFβ Signaling in T Cells Leads to Spontaneous T Cell Differentiation and Autoimmune Disease (2000) (936)
The Jnk1 and Jnk2 Protein Kinases Are Required for Regional Specific Apoptosis during Early Brain Development (1999) (929)
Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease. (2008) (922)
Toll-like receptor 3 promotes cross-priming to virus-infected cells (2005) (920)
RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems (2002) (914)
A Toll-like Receptor That Prevents Infection by Uropathogenic Bacteria (2004) (886)
Interleukin (IL)-6 Directs the Differentiation of IL-4–producing CD4+ T Cells (1997) (886)
The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors (2002) (885)
Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression (2007) (884)
Neuronal Activity–Induced Gadd45b Promotes Epigenetic DNA Demethylation and Adult Neurogenesis (2009) (876)
The Nalp3 inflammasome is essential for the development of silicosis (2008) (844)
RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement (2005) (826)
Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome (2015) (815)
A dominant function for interleukin 27 in generating interleukin 10–producing anti-inflammatory T cells (2007) (809)
Mice deficient for the CD40 ligand. (1994) (809)
The polarization of immune cells in the tumour environment by TGFβ (2010) (808)
The NLR gene family: a standard nomenclature. (2008) (805)
Essential Role of Phosphoinositide Metabolism in Synaptic Vesicle Recycling (1999) (790)
Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease. (2008) (784)
A protective function for interleukin 17A in T cell–mediated intestinal inflammation (2009) (777)
Interchromosomal associations between alternatively expressed loci (2005) (764)
T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation. (2007) (762)
TGF-β: A Master of All T Cell Trades (2008) (744)
Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-β signals in vivo (2005) (715)
Transforming Growth Factor-β Controls Development, Homeostasis, and Tolerance of T Cells by Regulatory T Cell-Dependent and -Independent Mechanisms (2006) (715)
Inflammasome recognition of influenza virus is essential for adaptive immune responses (2009) (695)
Defective T cell differentiation in the absence of Jnk1. (1998) (665)
Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome (2009) (650)
Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells (2013) (648)
Viral infection switches non-plasmacytoid dendritic cells into high interferon producers (2003) (642)
Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling (2015) (636)
Conventional T-bet+Foxp3− Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection (2007) (635)
Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation. (2007) (632)
Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation (2015) (628)
Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter. (2005) (627)
IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine (2012) (623)
Control of TH17 cells occurs in the Small Intestine (2011) (600)
Neural tube, skeletal and body wall defects in mice lacking transcription factor AP-2 (1996) (593)
T cells that cannot respond to TGF-β escape control by CD4+CD25+ regulatory T cells (2005) (591)
Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses (2006) (589)
Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome. (2009) (576)
Immunoglobulin A Coating Identifies Colitogenic Bacteria in Inflammatory Bowel Disease (2014) (576)
TH2, allergy and group 2 innate lymphoid cells (2013) (574)
Development and function of human innate immune cells in a humanized mouse model (2014) (572)
JNK Expression by Macrophages Promotes Obesity-Induced Insulin Resistance and Inflammation (2013) (567)
Distinct Roles in Lymphoid Organogenesis for Lymphotoxins α and β Revealed in Lymphotoxin β–Deficient Mice (1997) (564)
Activation of the STAT signaling pathway can cause expression of caspase 1 and apoptosis (1997) (563)
Th17 cells express interleukin-10 receptor and are controlled by Foxp3⁻ and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner. (2011) (560)
Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis (1995) (557)
The fate and lifespan of human monocyte subsets in steady state and systemic inflammation (2017) (555)
Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA (2014) (552)
Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus (2005) (549)
Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand (1995) (546)
The Role of Fas in Autoimmune Diabetes (1997) (546)
Mechanism of Transforming Growth Factor β–induced Inhibition of T Helper Type 1 Differentiation (2002) (544)
NLRP6 Inflammasome Orchestrates the Colonic Host-Microbial Interface by Regulating Goblet Cell Mucus Secretion (2014) (539)
Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasome (2007) (528)
Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8, and 9 to stimulate polyvalent immunity (2006) (527)
Detrimental Contribution of the Toll-Like Receptor (TLR)3 to Influenza A Virus–Induced Acute Pneumonia (2006) (525)
Immune-mediated eradication of tumors through the blockade of transforming growth factor-β signaling in T cells (2001) (523)
The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection (2006) (517)
Conditional Vascular Cell Adhesion Molecule 1 Deletion in Mice (2001) (517)
Transforming growth factor-β in T-cell biology (2002) (516)
Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways (2003) (514)
The Bax Subfamily of Bcl2-Related Proteins Is Essential for Apoptotic Signal Transduction by c-Jun NH2-Terminal Kinase (2002) (514)
Mechanism of p38 MAP kinase activation in vivo. (2003) (512)
Differentiation of CD4+ T cells to Th1 cells requires MAP kinase JNK2. (1998) (507)
Anti-inflammatory and pro-inflammatory roles of TGF-beta, IL-10, and IL-22 in immunity and autoimmunity. (2009) (502)
TGF-beta regulates in vivo expansion of Foxp3-expressing CD4+CD25+ regulatory T cells responsible for protection against diabetes. (2004) (494)
Topological organization of multichromosomal regions by the long intergenic noncoding RNA Firre (2014) (491)
Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation. (2007) (490)
β-Amyloid Induces Neuronal Apoptosis Via a Mechanism that Involves the c-Jun N-Terminal Kinase Pathway and the Induction of Fas Ligand (2001) (486)
The Inflammasome: First Line of the Immune Response to Cell Stress (2006) (481)
DNA methylation in the human γδβ-globin locus in erythroid and nonerythroid tissues (1980) (480)
A physical map of the DNA regions flanking the rabbit β-globin gene (1977) (479)
A Selective Activity-Dependent Requirement for Dynamin 1 in Synaptic Vesicle Endocytosis (2007) (473)
Interferon‐γ expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway (1998) (473)
Long-range intrachromosomal interactions in the T helper type 2 cytokine locus (2004) (471)
Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice (2002) (471)
Requirement for CD154 in the progression of atherosclerosis (1999) (470)
m6A mRNA methylation controls T cell homeostasis by targeting IL-7/STAT5/SOCS pathway (2017) (468)
Requirement for CD40 Ligand in Costimulation Induction, T Cell Activation, and Experimental Allergic Encephalomyelitis (1996) (467)
Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations (2015) (464)
Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease. (2000) (464)
The Role of CD40 Ligand in Costimulation and T‐Cell Activation (1996) (461)
Contextual regulation of inflammation: a duet by transforming growth factor-beta and interleukin-10. (2008) (458)
Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense. (2012) (451)
Mechanisms of programmed cell death in the developing brain (2000) (449)
Expression of Interleukin 9 in the Lungs of Transgenic Mice Causes Airway Inflammation, Mast Cell Hyperplasia, and Bronchial Hyperresponsiveness (1998) (448)
Signals mediated by transforming growth factor-β initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease (2006) (446)
Expansion or Elimination of B Cells In Vivo: Dual Roles for CD40- and Fas (CD95)-Ligands Modulated by the B Cell Antigen Receptor (1996) (441)
Defective IL‐12 production in mitogen‐activated protein (MAP) kinase kinase 3 (Mkk3)‐deficient mice (1999) (440)
Transforming Growth Factor-β and the Immune Response: Implications for Anticancer Therapy (2007) (438)
Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch. (2007) (432)
Combination delivery of TGF-β inhibitor and IL-2 by nanoscale liposomal polymeric gels enhances tumour immunotherapy. (2012) (425)
Transforming growth factor-beta in T-cell biology. (2002) (424)
CD4+CD25+ T regulatory cells control anti-islet CD8+ T cells through TGF-β–TGF-β receptor interactions in type 1 diabetes (2003) (423)
STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: A critical role of STAT3 in innate immunity (2003) (421)
Mice Lacking Endogenous IL-10–Producing Regulatory B Cells Develop Exacerbated Disease and Present with an Increased Frequency of Th1/Th17 but a Decrease in Regulatory T Cells (2011) (420)
HIV infection is blocked in vitro by recombinant soluble CD4 (1988) (420)
Cutting Edge: Caspase-1 Independent IL-1β Production Is Critical for Host Resistance to Mycobacterium tuberculosis and Does Not Require TLR Signaling In Vivo (2010) (415)
Blocking TGF-β–Smad2/3 innate immune signaling mitigates Alzheimer-like pathology (2008) (412)
Shigella-induced Apoptosis Is Dependent on Caspase-1 Which Binds to IpaB* (1998) (412)
Disruption of TGF-β signaling in T cells accelerates atherosclerosis (2003) (411)
Phosphatidylserine Receptor Is Required for Clearance of Apoptotic Cells (2003) (407)
Activation of interferon-gamma inducing factor mediated by interleukin-1beta converting enzyme. (1997) (406)
Cutting Edge: TGF-β Inhibits Th Type 2 Development Through Inhibition of GATA-3 Expression (2000) (405)
JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease. (2004) (405)
Transgenic mice demonstrate AP-1 (activator protein-1) transactivation is required for tumor promotion. (1999) (404)
Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-beta signals in vivo. (2005) (401)
A critical role of neural-specific JNK3 for ischemic apoptosis (2003) (398)
ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity (2008) (398)
Regulation of IL‐4 expression by the transcription factor JunB during T helper cell differentiation (1999) (397)
CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells (1996) (390)
Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knockin tiger mouse. (2006) (389)
Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis. (2005) (389)
Does Toll-like receptor 3 play a biological role in virus infections? (2004) (388)
Phenotypic and physiologic characterization of transgenic mice expressing interleukin 4 in the lung: lymphocytic and eosinophilic inflammation without airway hyperreactivity. (1996) (387)
Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4 (2010) (384)
Mice lacking the MHC class II transactivator (CIITA) show tissue-specific impairment of MHC class II expression. (1996) (384)
Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13–induced tissue responses and apoptosis (2009) (384)
MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines. (2001) (383)
Microglial activation resulting from CD40-CD40L interaction after beta-amyloid stimulation. (1999) (377)
Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms. (2006) (375)
Suppression of Inflammatory Cytokine Production by Carbon Monoxide Involves the JNK Pathway and AP-1* (2003) (370)
Activation of mast cells by double-stranded RNA: evidence for activation through Toll-like receptor 3. (2004) (368)
STAT3 is required for Flt3L-dependent dendritic cell differentiation. (2003) (363)
Impaired PtdIns(4,5)P2 synthesis in nerve terminals produces defects in synaptic vesicle trafficking (2004) (363)
OspC facilitates Borrelia burgdorferi invasion of Ixodes scapularis salivary glands. (2004) (360)
Molecular Mechanism of NLRP3 Inflammasome Activation (2010) (360)
Disruption of CD40-CD40 ligand interactions results in an enhanced susceptibility to Leishmania amazonensis infection. (1996) (359)
Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis (2006) (359)
Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis (2015) (358)
Cutting Edge: Changes in Histone Acetylation at the IL-4 and IFN-γ Loci Accompany Th1/Th2 Differentiation (2002) (358)
Immune-Mediated Eradication of Tumors through the Blockade of Transforming Growth Factor-beta Signaling in T Cells (2002) (357)
Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor (2005) (357)
JNK is required for effector T-cell function but not for T-cell activation (2000) (357)
Wnk4 controls blood pressure and potassium homeostasis via regulation of mass and activity of the distal convoluted tubule (2006) (351)
Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells (2017) (351)
A central role of CD40 ligand in the regulation of CD4+ T-cell responses. (1996) (346)
CD40L-deficient mice show deficits in antiviral immunity and have an impaired memory CD8+ CTL response (1996) (337)
Diabetes and tolerance in transgenic mice expressing class II MHC molecules in pancreatic beta cells (1988) (337)
Class II transactivator (CIITA) is sufficient for the inducible expression of major histocompatibility complex class II genes (1994) (337)
The rabbit β-globin gene contains a large insert in the coding sequence (1977) (336)
Early Growth Response Gene 1–mediated Apoptosis Is Essential for Transforming Growth Factor β1–induced Pulmonary Fibrosis (2004) (334)
Pancreatic lymph node-derived CD4(+)CD25(+) Treg cells: highly potent regulators of diabetes that require TRANCE-RANK signals. (2002) (332)
Regulation of the antimicrobial response by NLR proteins. (2011) (330)
DNA methylation and the regulation of globin gene expression (1983) (329)
Malarial Hemozoin Activates the NLRP3 Inflammasome through Lyn and Syk Kinases (2009) (329)
‘Yin–Yang’ functions of transforming growth factor‐β and T regulatory cells in immune regulation (2007) (327)
Chemical genetic analysis of the time course of signal transduction by JNK. (2006) (326)
T helper cell differentiation: regulation by cis elements and epigenetics. (2006) (326)
Deficiency in caspase-9 or caspase-3 induces compensatory caspase activation (2000) (321)
AP‐1 transcriptional activity requires both T‐cell receptor‐mediated and co‐stimulatory signals in primary T lymphocytes. (1994) (320)
Involvement of Toll-like receptor 5 in the recognition of flagellated bacteria (2006) (314)
Caspase activation and neuroprotection in caspase-3- deficient mice after in vivo cerebral ischemia and in vitro oxygen glucose deprivation (2002) (311)
Recent advances in IL-22 biology. (2011) (309)
Microbial pathogen-induced necrotic cell death mediated by the inflammasome components CIAS1/cryopyrin/NLRP3 and ASC. (2007) (308)
JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species. (2004) (305)
Inflammasome-derived IL-1β production induces nitric oxide–mediated resistance to Leishmania (2013) (303)
MspI, an isoschizomer of hpaII which cleaves both unmethylated and methylated hpaII sites. (1978) (302)
NF-kappa B activation by the pre-T cell receptor serves as a selective survival signal in T lymphocyte development. (2000) (300)
Human hemato-lymphoid system mice: current use and future potential for medicine. (2013) (299)
Targeted disruption of the MKK4 gene causes embryonic death, inhibition of c-Jun NH2-terminal kinase activation, and defects in AP-1 transcriptional activity. (1997) (299)
Evidence that the multidrug resistance protein (MRP) functions as a co-transporter of glutathione and natural product toxins. (1997) (297)
Interleukin‐10 targets p38 MAPK to modulate ARE‐dependent TNF mRNA translation and limit intestinal pathology (2001) (296)
Primary cilia regulate hippocampal neurogenesis by mediating sonic hedgehog signaling (2008) (295)
The relationship of IL-4- and IFNγ-producing T cells studied by lineage ablation of IL-4-producing cells (1993) (294)
An essential role of the Forkhead-box transcription factor Foxo1 in control of T cell homeostasis and tolerance. (2009) (293)
Transforming growth factor-β controls T helper type 1 cell development through regulation of natural killer cell interferon-γ (2005) (290)
Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis (2005) (289)
Hypoxia-Ischemia Induces DNA Synthesis without Cell Proliferation in Dying Neurons in Adult Rodent Brain (2004) (289)
Apoptosis: All's well that ends dead (1999) (287)
Inflammasome-activating nanoparticles as modular systems for optimizing vaccine efficacy. (2009) (282)
Organization and evolution of the class I gene family in the major histocompatibility complex of the C57BL/10 mouse (1984) (281)
Class II transactivator regulates the expression of multiple genes involved in antigen presentation (1995) (280)
Stat3 controls lysosomal-mediated cell death in vivo (2011) (278)
Carbon Monoxide Inhibition of Apoptosis during Ischemia-Reperfusion Lung Injury Is Dependent on the p38 Mitogen-activated Protein Kinase Pathway and Involves Caspase 3* (2003) (277)
Disruption of TGF-beta signaling in T cells accelerates atherosclerosis. (2003) (276)
A novel role for murine IL-4 in vivo: induction of MUC5AC gene expression and mucin hypersecretion. (1997) (275)
A Yersinia effector protein promotes virulence by preventing inflammasome recognition of the type III secretion system. (2010) (274)
Caspase activity mediates the differentiation of embryonic stem cells. (2008) (274)
The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function (2006) (273)
IL-10 from CD4+CD25−Foxp3−CD127− Adaptive Regulatory T Cells Modulates Parasite Clearance and Pathology during Malaria Infection (2008) (269)
Microbiota-induced activation of epithelial IL-6 signaling links inflammasome-driven inflammation with transmissible cancer (2013) (269)
Impaired T cell-mediated macrophage activation in CD40 ligand-deficient mice. (1996) (267)
Platelet CD40L mediates thrombotic and inflammatory processes in atherosclerosis. (2010) (267)
Regulation of IL-4 gene expression by distal regulatory elements and GATA-3 at the chromatin level. (2001) (266)
Genetic Dissection of the Cellular Pathways and Signaling Mechanisms in Modeled Tumor Necrosis Factor–induced Crohn's-like Inflammatory Bowel Disease (2002) (266)
JunD mediates survival signaling by the JNK signal transduction pathway. (2003) (262)
Pulmonary overexpression of IL-9 induces Th2 cytokine expression, leading to immune pathology. (2002) (259)
Defective Antigen Processing in GILT-Free Mice (2001) (259)
Regulation of innate and adaptive immune responses by MAP kinase phosphatase 5 (2004) (255)
The JNK Pathway Regulates the In Vivo Deletion of Immature CD4+CD8+ Thymocytes (1998) (254)
Tolerance rather than immunity protects from Helicobacter pylori-induced gastric preneoplasia. (2011) (253)
Distinct roles in lymphoid organogenesis for lymphotoxins alpha and beta revealed in lymphotoxin beta-deficient mice. (1997) (252)
Disruption of the murine MRP (multidrug resistance protein) gene leads to increased sensitivity to etoposide (VP-16) and increased levels of glutathione. (1997) (248)
Caspase-11 stimulates rapid flagellin-independent pyroptosis in response to Legionella pneumophila (2013) (247)
Response to local inflammation of IL-1 beta-converting enzyme- deficient mice. (1997) (247)
T-cell tolerance by clonal anergy in transgenic mice with nonlymphoid expression of MHC class II I–E (1989) (246)
Suppression of skin tumorigenesis in c-Jun NH(2)-terminal kinase-2-deficient mice. (2001) (245)
Requirement of the JIP1 scaffold protein for stress-induced JNK activation. (2001) (244)
The microRNA miR-181 is a critical cellular metabolic rheostat essential for NKT cell ontogenesis and lymphocyte development and homeostasis. (2013) (242)
The construction of cosmid libraries which can be used to transform eukaryotic cells. (1982) (240)
Anti-Mitochondrial Antibodies and Primary Biliary Cirrhosis in TGF-β Receptor II Dominant-Negative Mice1 (2006) (240)
Cutting Edge: Critical Role of Inducible Costimulator in Germinal Center Reactions1 (2001) (239)
Elimination of Borrelia burgdorferi from vector ticks feeding on OspA-immunized mice. (1992) (238)
Sepsis-induced suppression of lung innate immunity is mediated by IRAK-M. (2006) (236)
CD4 T-cell differentiation and inflammatory bowel disease. (2009) (235)
Decreased Synaptic Vesicle Recycling Efficiency and Cognitive Deficits in Amphiphysin 1 Knockout Mice (2002) (234)
Multisite phosphorylation regulates Bim stability and apoptotic activity. (2008) (234)
Apoptotic hepatocyte DNA inhibits hepatic stellate cell chemotaxis via toll‐like receptor 9 (2007) (234)
Dynamic signaling by T follicular helper cells during germinal center B cell selection (2014) (233)
KLRG1+ Effector CD8+ T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity (2018) (233)
The structure of a mutant H–2 gene suggests that the generation of polymorphism in H–2 genes may occur by gene conversion-like events (1983) (231)
Recent advances in dynamic m6A RNA modification (2016) (229)
Autocrine transforming growth factor-β1 promotes in vivo Th17 cell differentiation. (2011) (229)
Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells (2017) (228)
Specific pathophysiological functions of JNK isoforms in the brain (2005) (228)
Sequential MyD88-independent and -dependent activation of innate immune responses to intracellular bacterial infection. (2003) (227)
Programmed Cell Death of Developing Mammalian Neurons after Genetic Deletion of Caspases (2001) (227)
Bcl6 expression specifies the T follicular helper cell program in vivo (2012) (226)
Blocking activator protein-1 activity, but not activating retinoic acid response element, is required for the antitumor promotion effect of retinoic acid. (1997) (225)
A Salmonella protein causes macrophage cell death by inducing autophagy (2003) (224)
The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury (2016) (224)
Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity (2019) (222)
A crucial role of caspase-3 in osteogenic differentiation of bone marrow stromal stem cells. (2004) (222)
Humanized mice for modeling human infectious disease: challenges, progress, and outlook. (2009) (221)
The invariant chain is required for intracellular transport and function of major histocompatibility complex class II molecules (1994) (221)
Targeted expression of IL-11 in the murine airway causes lymphocytic inflammation, bronchial remodeling, and airways obstruction. (1996) (220)
Airway epithelial cell expression of interleukin-6 in transgenic mice. Uncoupling of airway inflammation and bronchial hyperreactivity. (1994) (220)
Local expression of TNFalpha in neonatal NOD mice promotes diabetes by enhancing presentation of islet antigens. (1998) (219)
Regulation of the Th2 cytokine locus by a locus control region. (2003) (219)
TLR9 and the NLRP3 inflammasome link acinar cell death with inflammation in acute pancreatitis. (2011) (219)
Serum Amyloid A Activates the NLRP3 Inflammasome and Promotes Th17 Allergic Asthma in Mice (2011) (219)
Role of CD40 ligand in amyloidosis in transgenic Alzheimer's mice (2002) (216)
Blockade of CD40 ligand-CD40 interaction impairs CD4+ T cell-mediated alloreactivity by inhibiting mature donor T cell expansion and function after bone marrow transplantation. (1997) (215)
Bacterial flagellin stimulates Toll-like receptor 5-dependent defense against vancomycin-resistant Enterococcus infection. (2010) (215)
Immune-microbiota interactions in health and disease. (2015) (214)
IL-22 Deficiency Alters Colonic Microbiota To Be Transmissible and Colitogenic (2013) (214)
Transgenic expression of human signal regulatory protein alpha in Rag2−/−γc−/− mice improves engraftment of human hematopoietic cells in humanized mice (2011) (214)
The different faces of Notch in T-helper-cell differentiation (2009) (213)
Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung (2011) (211)
NLRP3 inflammasome plays a critical role in the pathogenesis of hydroxyapatite-associated arthropathy (2011) (211)
DNA methylation at a CCGG sequence in the large intron of the rabbit beta-globin gene: tissue-specific variations. (1978) (210)
Polarization of IL-4- and IFN-gamma-producing CD4+ T cells following activation of naive CD4+ T cells. (1997) (210)
Costimulator B7-1 confers antigen-presenting-cell function to parenchymal tissue and in conjunction with tumor necrosis factor alpha leads to autoimmunity in transgenic mice. (1994) (208)
TL1A–DR3 interaction regulates Th17 cell function and Th17-mediated autoimmune disease (2008) (208)
Caspase-1 regulates the inflammatory process leading to autoimmune demyelination. (1999) (206)
Transforming growth factor-beta controls T helper type 1 cell development through regulation of natural killer cell interferon-gamma. (2005) (206)
DNA sequences necessary for transcription of the rabbit β-globin gene in vivo (1982) (205)
The long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan (2016) (205)
Toll-like receptor 7 mitigates lethal West Nile encephalitis via interleukin 23-dependent immune cell infiltration and homing. (2009) (204)
Interleukin-13 mediates a fundamental pathway for airway epithelial mucus induced by CD4 T cells and interleukin-9. (2002) (204)
Circuit Design Features of a Stable Two-Cell System (2018) (203)
Deletion of TLR3 Alters the Pulmonary Immune Environment and Mucus Production during Respiratory Syncytial Virus Infection (2006) (202)
Autocrine/paracrine TGFβ1 is required for the development of epidermal Langerhans cells (2007) (202)
How diverse--CD4 effector T cells and their functions. (2009) (202)
NOD2-Deficient Mice Have Impaired Resistance to Mycobacterium tuberculosis Infection through Defective Innate and Adaptive Immunity1 (2008) (201)
Toll-Like Receptor 3 Is a Potent Negative Regulator of Axonal Growth in Mammals (2007) (201)
TWEAK, via its receptor Fn14, is a novel regulator of mesenchymal progenitor cells and skeletal muscle regeneration (2006) (201)
CD4+CD25+ T regulatory cells control anti-islet CD8+ T cells through TGF-beta-TGF-beta receptor interactions in type 1 diabetes. (2003) (200)
Impaired membrane resealing and autoimmune myositis in synaptotagmin VII–deficient mice (2003) (200)
Inflammasome-mediated regulation of hepatic stellate cells. (2009) (200)
Virus binding to a plasma membrane receptor triggers interleukin-1 alpha-mediated proinflammatory macrophage response in vivo. (2009) (198)
Analysis of the β-δ-globin gene loci in normal and hb lepore DNA: Direct determination of gene linkage and intergene distance (1978) (197)
Transient subversion of CD40 ligand function diminishes immune responses to adenovirus vectors in mouse liver and lung tissues (1996) (195)
Beta 2-microglobulin is not required for cell surface expression of the murine class I histocompatibility antigen H-2Db or of a truncated H-2Db. (1986) (195)
Reactive oxygen species and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase mediate hyperoxia-induced cell death in lung epithelium. (2003) (195)
Domain interactions of H–2 class I antigens alter cytotoxic T-cell recognition sites (1984) (195)
Isolation of β-globin related genes from a human cosmid library. (1981) (194)
Role of CD4+ T cells in pathogenesis associated with Leishmania amazonensis infection. (1997) (193)
Th9 Cells Drive Host Immunity against Gastrointestinal Worm Infection. (2013) (192)
A method for the recovery of DNA from agarose gels. (1978) (192)
The dual nature of TH17 cells: shifting the focus to function (2010) (190)
β + Thalassemia: Aberrant splicing results from a single point mutation in an intron (1981) (189)
Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo (2010) (189)
Th2-specific chromatin remodeling and enhancer activity in the Th2 cytokine locus control region. (2004) (189)
Outer surface proteins E and F of Borrelia burgdorferi, the agent of Lyme disease (1994) (188)
CD40 ligand-deficient mice generate a normal primary cytotoxic T-lymphocyte response but a defective humoral response to a viral infection (1996) (188)
A novel MHC class II epitope expressed in thymic medulla but not cortex (1989) (188)
β-Globin gene inactivation by DNA translocation in γβ-thalassaemi (1983) (188)
m6A mRNA methylation sustains Treg suppressive functions (2018) (188)
Roles of OspA, OspB, and flagellin in protective immunity to Lyme borreliosis in laboratory mice (1992) (187)
Innate sensors of pathogen and stress: linking inflammation to obesity. (2013) (187)
Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease (2016) (187)
Salmonella Typhimurium Type III Secretion Effectors Stimulate Innate Immune Responses in Cultured Epithelial Cells (2009) (186)
The role of the T cell costimulator B7-1 in autoimmunity and the induction and maintenance of tolerance to peripheral antigen. (1994) (186)
Borrelia burgdorferi genes selectively expressed in the infected host. (1995) (186)
Follicular helper T cells progressively differentiate to regulate the germinal center response (2016) (185)
Anti-SIRPα antibody immunotherapy enhances neutrophil and macrophage antitumor activity (2017) (185)
Coexpression of B7-1 and viral ("self") transgenes in pancreatic beta cells can break peripheral ignorance and lead to spontaneous autoimmune diabetes. (1995) (185)
Critical role of c-jun (NH2) terminal kinase in paracetamol- induced acute liver failure (2006) (184)
Potential intestinal infection and faecal–oral transmission of SARS-CoV-2 (2021) (183)
Microglia Recognize Double-Stranded RNA via TLR31 (2006) (183)
Opposing effects of TGF-beta and IL-15 cytokines control the number of short-lived effector CD8+ T cells. (2009) (183)
Helicobacter pylori-Induced Th17 Responses Modulate Th1 Cell Responses, Benefit Bacterial Growth, and Contribute to Pathology in Mice (2010) (183)
Transgenic tumor necrosis factor (TNF)-alpha production in pancreatic islets leads to insulitis, not diabetes. Distinct patterns of inflammation in TNF-alpha and TNF-beta transgenic mice. (1993) (183)
Role of dendritic cells in the priming of CD4+ T lymphocytes to peptide antigen in vivo. (1993) (182)
MKK3 mitogen-activated protein kinase pathway mediates carbon monoxide-induced protection against oxidant-induced lung injury. (2003) (181)
GADD45gamma mediates the activation of the p38 and JNK MAP kinase pathways and cytokine production in effector TH1 cells. (2001) (180)
T-cells in alzheimer’s disease (2007) (180)
Thymic self-reactivity selects natural interleukin 17-producing T cells that can regulate peripheral inflammation (2009) (180)
Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expression. (1999) (179)
STAT Activation by Epidermal Growth Factor (EGF) and Amphiregulin (1996) (178)
Defective T cell activation and autoimmune disorder in Stra13-deficient mice (2001) (178)
Survival signaling mediated by c-Jun NH2-terminal kinase in transformed B lymphoblasts (2002) (177)
Role of the guanosine triphosphatase Rac2 in T helper 1 cell differentiation. (2000) (175)
Inflammasomes: far beyond inflammation (2012) (175)
Hematopoietic Stem Cell Niches Produce Lineage-Instructive Signals to Control Multipotent Progenitor Differentiation. (2016) (174)
Th1 and Th2 cells. (2001) (174)
In vivo properties of monocyte chemoattractant protein‐1 (1997) (174)
Deficiency of c-Jun-NH(2)-terminal kinase-1 in mice enhances skin tumor development by 12-O-tetradecanoylphorbol-13-acetate. (2002) (174)
The JNK and P38 MAP kinase signaling pathways in T cell-mediated immune responses. (2000) (173)
Nlrp6 regulates intestinal antiviral innate immunity (2015) (173)
CD40-CD40 ligand costimulation is required for generating antiviral CD4 T cell responses but is dispensable for CD8 T cell responses. (1999) (172)
S1P1 receptor overrides regulatory T cell-mediated immune suppression through Akt-mTOR (2009) (171)
Toll-like receptor 3 is an essential component of the innate stress response in virus-induced cardiac injury. (2007) (171)
Carbon Monoxide Modulates Fas/Fas Ligand, Caspases, and Bcl-2 Family Proteins via the p38α Mitogen-activated Protein Kinase Pathway during Ischemia-Reperfusion Lung Injury* (2003) (170)
Kv1.3 Channel Gene-Targeted Deletion Produces “Super-Smeller Mice” with Altered Glomeruli, Interacting Scaffolding Proteins, and Biophysics (2004) (170)
NALP3-mediated inflammation is a principal cause of progressive renal failure in oxalate nephropathy (2013) (169)
An essential role for gp39, the ligand for CD40, in thymic selection (1995) (169)
Unexpected protective role for Toll-like receptor 3 in the arterial wall (2011) (168)
Role of beta 2-microglobulin in the intracellular transport and surface expression of murine class I histocompatibility molecules. (1989) (168)
Cleavage of FLICE (caspase‐8) by granzyme B during cytotoxic T lymphocyte‐induced apoptosis (1997) (168)
Caspase-11 Activation in Response to Bacterial Secretion Systems that Access the Host Cytosol (2013) (167)
Local expression of transgene encoded TNF alpha in islets prevents autoimmune diabetes in nonobese diabetic (NOD) mice by preventing the development of auto-reactive islet-specific T cells (1996) (167)
In the absence of a CD40 signal, B cells are tolerogenic. (1995) (166)
Transcriptional regulation of th2 differentiation by inducible costimulator. (2003) (166)
DNA sequences required for regulated expression of β-globin genes in murine erythroleukemia cells (1984) (165)
Airway hyperresponsiveness and airway obstruction in transgenic mice. Morphologic correlates in mice overexpressing interleukin (IL)-11 and IL-6 in the lung. (2000) (165)
The roles for cytokines in the generation and maintenance of regulatory T cells (2006) (164)
How are T(H)1 and T(H)2 effector cells made? (2009) (163)
TLR8 deficiency leads to autoimmunity in mice. (2010) (163)
Dynamic signaling by T follicular helper cells during germinal center B cell selection (2014) (162)
Memory/effector (CD45RBlo) CD4 T cells are controlled directly by IL-10 and cause IL-22–dependent intestinal pathology (2011) (162)
A mouse model for the human pathogen Salmonella typhi. (2010) (162)
The Hematopoiesis-Specific GTP-Binding Protein RhoH Is GTPase Deficient and Modulates Activities of Other Rho GTPases by an Inhibitory Function (2002) (162)
c-Jun NH2-Terminal Kinase Is Essential for the Regulation of AP-1 by Tumor Necrosis Factor (2003) (162)
Polyethyleneimine is a potent mucosal adjuvant for viral glycoprotein antigens (2012) (162)
TGF-β and Regulatory T Cell in Immunity and Autoimmunity (2008) (162)
JNK2 is a positive regulator of the cJun transcription factor. (2006) (161)
A Dual Role for TNF-α in Type 1 Diabetes: Islet-Specific Expression Abrogates the Ongoing Autoimmune Process When Induced Late but Not Early During Pathogenesis1 (2001) (161)
Estrogen prevents bone loss through transforming growth factor beta signaling in T cells. (2004) (161)
Production of IL-10 by CD4+ regulatory T cells during the resolution of infection promotes the maturation of memory CD8+ T cells (2015) (160)
Caspase-1, Caspase-8, and Calpain Are Dispensable for IL-33 Release by Macrophages1 (2009) (160)
Hypersensitive site 7 of the TH2 locus control region is essential for expressing TH2 cytokine genes and for long-range intrachromosomal interactions (2005) (160)
Macrophage phenotype controls long-term AKI outcomes--kidney regeneration versus atrophy. (2014) (159)
Long-term activation of TLR3 by Poly(I:C) induces inflammation and impairs lung function in mice (2009) (159)
Transgenic monocyte chemoattractant protein-1 (MCP-1) in pancreatic islets produces monocyte-rich insulitis without diabetes: abrogation by a second transgene expressing systemic MCP-1. (1997) (158)
Canonical autophagy dependent on the class III phosphoinositide-3 kinase Vps34 is required for naive T-cell homeostasis (2012) (158)
Impaired primary T cell responses in L-selectin-deficient mice (1996) (158)
Alpha-4 integrins and VCAM-1, but not MAdCAM-1, are essential for recruitment of mast cell progenitors to the inflamed lung. (2006) (158)
The inflammasome in pathogen recognition and inflammation (2007) (157)
Borrelia burgdorferi P35 and P37 proteins, expressed in vivo, elicit protective immunity. (1997) (156)
Regulated overexpression of interleukin 11 in the lung. Use to dissociate development-dependent and -independent phenotypes. (1997) (156)
Tolerance in transgenic mice expressing class II major histocompatibility complex on pancreatic acinar cells (1989) (156)
Cutting Edge: Deficiency in the E3 Ubiquitin Ligase Cbl-b Results in a Multifunctional Defect in T Cell TGF-β Sensitivity In Vitro and In Vivo (2006) (156)
Endothelial Cells Require STAT3 for Protection against Endotoxin-induced Inf lammation (2003) (155)
Diverse Mechanisms of Myocardial p38 Mitogen-Activated Protein Kinase Activation: Evidence for MKK-Independent Activation by a TAB1-Associated Mechanism Contributing to Injury During Myocardial Ischemia (2003) (155)
Induction of oral tolerance to cellular immune responses in the absence of Peyer's patches (2001) (152)
Fibroblasts and myofibroblasts of the intestinal lamina propria in physiology and disease. (2016) (151)
MDP‐induced interleukin‐1β processing requires Nod2 and CIAS1/NALP3 (2007) (151)
Innate immune receptors: key regulators of metabolic disease progression. (2013) (150)
Induction of Hepatitis by JNK-Mediated Expression of TNF-α (2009) (150)
Suppression of p53-dependent senescence by the JNK signal transduction pathway (2007) (147)
TLR-Independent Induction of Dendritic Cell Maturation and Adaptive Immunity by Negative-Strand RNA Viruses1 (2004) (147)
Loss of Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4) Reveals a Requirement for MAPK Signalling in Mouse Sex Determination (2009) (146)
The Cd40 ligand (1997) (145)
The Immunoglobulin (IgG) Antibody Response to OspA and OspB Correlates with Severe and Prolonged Lyme Arthritis and the IgG Response to P35 Correlates with Mild and Brief Arthritis (1999) (145)
Reciprocal regulation of CD30 expression on CD4+ T cells by IL-4 and IFN-gamma. (1997) (144)
γ-β-Thalassaemia studies showing that deletion of the γ- and δ-genes influences β-globin gene expression in man (1980) (144)
Efficient differentiation and function of human macrophages in humanized CSF-1 mice. (2011) (143)
Humanized hemato-lymphoid system mice (2016) (143)
Transforming Growth Factor–β Signaling in T Cells Promotes Stabilization of Atherosclerotic Plaques Through an Interleukin-17–Dependent Pathway (2013) (142)
Regulating human Th17 cells via differential expression of IL-1 receptor. (2010) (142)
Peptide and protein antigens require distinct antigen-presenting cell subsets for the priming of CD4+ T cells. (1995) (142)
Requirement for Invariant Chain in B Cell Maturation and Function (1996) (141)
A lupus-like syndrome develops in mice lacking the Ro 60-kDa protein, a major lupus autoantigen (2003) (141)
TLR3 Deletion Limits Mortality and Disease Severity due to Phlebovirus Infection1 (2006) (140)
The voltage-gated potassium channel Kv1.3 regulates peripheral insulin sensitivity. (2004) (140)
Roles of IL-4 and IFN-gamma in stabilizing the T helper cell type 1 and 2 phenotype. (1997) (140)
Role of the intestinal microbiome in liver disease. (2013) (140)
RNA m6A modification and its function in diseases (2018) (140)
Strain‐Dependent Neurodevelopmental Abnormalities in Caspase‐3‐Deficient Mice (2002) (139)
Suppression of Ras-stimulated transformation by the JNK signal transduction pathway. (2003) (139)
Progress in upscaling Miscanthus biomass production for the European bio‐economy with seed‐based hybrids (2017) (139)
The voltage-gated potassium channel Kv1.3 regulates energy homeostasis and body weight. (2003) (138)
CD40 Ligand-Mediated Interactions Are Involved in the Generation of Memory CD8+ Cytotoxic T Lymphocytes (CTL) but Are Not Required for the Maintenance of CTL Memory following Virus Infection (1998) (138)
Inflammasome activation in infected macrophages drives COVID-19 pathology (2022) (137)
NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells (2012) (137)
c-Jun NH2-Terminal Kinase Inhibits Targeting of the Protein Phosphatase Calcineurin to NFATc1 (2000) (137)
Role of Cathepsin S-Dependent Epithelial Cell Apoptosis in IFN-γ-Induced Alveolar Remodeling and Pulmonary Emphysema1 (2005) (136)
Cell-specific heterogeneity in sensitivity of phosphatidylinositol-anchored membrane antigens to release by phospholipase C. (1988) (136)
c-Jun NH2-Terminal Kinase (JNK)1 and JNK2 Have Distinct Roles in CD8+ T Cell Activation (2002) (135)
Molecular biology of the H-2 histocompatibility complex. (1986) (135)
Structure of the murine immune response I-Aβ locus: Sequence of the I-Aβ gene and an adjacent β-chain second domain exon (1983) (135)
and Metabolic Disease (2014) (135)
Paracrine orchestration of intestinal tumorigenesis by a mesenchymal niche (2020) (134)
MyD88 signalling in colonic mononuclear phagocytes drives colitis in IL-10 deficient mice (2012) (132)
Cell fate decision: T-helper 1 and 2 subsets in immune responses (2000) (131)
Transgenic mice selectively lacking MHC class II (I-E) antigen expression on B cells: An in vivo approach to investigate la gene function (1987) (130)
Gadd45β is important for perpetuating cognate and inflammatory signals in T cells (2004) (130)
Transcription mediated by NFAT is highly inducible in effector CD4+ T helper 2 (Th2) cells but not in Th1 cells (1997) (130)
Signal transduction by MAP kinases in T lymphocytes (2001) (129)
CD40 signaling regulates innate and adaptive activation of microglia in response to amyloid β‐peptide (2005) (129)
CD40 is expressed and functional on neuronal cells (2002) (129)
Type IV Secretion-Dependent Activation of Host MAP Kinases Induces an Increased Proinflammatory Cytokine Response to Legionella pneumophila (2008) (129)
Macrophages sense and kill bacteria through carbon monoxide-dependent inflammasome activation. (2014) (129)
TLR-2–Activated B Cells Suppress Helicobacter-Induced Preneoplastic Gastric Immunopathology by Inducing T Regulatory-1 Cells (2011) (129)
Renalase deficiency aggravates ischemic myocardial damage. (2011) (129)
Unraveling the Genetics of Autoimmunity (2010) (128)
Comparison of cloned rabbit and mouse β-globin genes showing strong evolutionary divergence of two homologous pairs of introns (1978) (128)
Insulitis in transgenic mice expressing tumor necrosis factor beta (lymphotoxin) in the pancreas. (1992) (128)
Metabolic signaling in T cells (2020) (127)
Oxysterol Sensing through the Receptor GPR183 Promotes the Lymphoid-Tissue-Inducing Function of Innate Lymphoid Cells and Colonic Inflammation (2018) (127)
Reprogramming the signalling requirement for AP-1 (activator protein-1) activation during differentiation of precursor CD4+ T-cells into effector Th1 and Th2 cells. (1997) (127)
Tumor suppressor CYLD regulates acute lung injury in lethal Streptococcus pneumoniae infections. (2007) (127)
Ventilator-induced Lung Injury Is Mediated by the NLRP3 Inflammasome (2012) (126)
Physical mapping of the globin gene deletion in hereditary persistence of foetal haemoglobin (HPFH). (1980) (126)
Targeted Expression of Calcitonin Gene‐Related Peptide to Osteoblasts Increases Bone Density in Mice (1999) (124)
Role of STAT3 in liver regeneration: survival, DNA synthesis, inflammatory reaction and liver mass recovery (2007) (123)
Role of MLK3 in the Regulation of Mitogen-Activated Protein Kinase Signaling Cascades (2005) (123)
High Resolution Genetic Mapping by Genome Sequencing Reveals Genome Duplication and Tetraploid Genetic Structure of the Diploid Miscanthus sinensis (2012) (122)
The Translation of Non-Canonical Open Reading Frames Controls Mucosal Immunity (2018) (122)
Chitinase 3-like-1 promotes Streptococcus pneumoniae killing and augments host tolerance to lung antibacterial responses. (2012) (122)
p38 MAPK Autophosphorylation Drives Macrophage IL-12 Production during Intracellular Infection1 (2005) (122)
Carbon Monoxide Inhibits T Lymphocyte Proliferation via Caspase-Dependent Pathway1 (2004) (122)
TGF-β signaling in dendritic cells is a prerequisite for the control of autoimmune encephalomyelitis (2008) (122)
Gut microbiota translocation to the pancreatic lymph nodes triggers NOD2 activation and contributes to T1D onset (2016) (122)
A nonpolymorphic class I gene in the murine major histocompatibility complex (1984) (121)
IL-13Ralpha2 and IL-10 coordinately suppress airway inflammation, airway-hyperreactivity, and fibrosis in mice. (2007) (121)
Amyloid Beta‐Induced Neuronal Death is Bax‐Dependent but Caspase‐Independent (2000) (120)
Innate instruction of adaptive immunity revisited: the inflammasome (2009) (120)
Differential involvement of p38 mitogen‐activated protein kinase kinases MKK3 and MKK6 in T‐cell apoptosis (2002) (120)
Improving human hemato-lymphoid-system mice by cytokine knock-in gene replacement. (2011) (120)
The Stromal Intervention: Regulation of Immunity and Inflammation at the Epithelial-Mesenchymal Barrier (2017) (120)
TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway. (2011) (120)
Cutting edge: sustained expansion of CD8+ T cells requires CD154 expression by Th cells in acute graft versus host disease. (1999) (119)
An Antibiotic-Responsive Mouse Model of Fulminant Ulcerative Colitis (2008) (119)
Transcriptional Reprogramming during Effector‐to‐Memory Transition Renders CD4+ T Cells Permissive for Latent HIV‐1 Infection (2017) (119)
Arthropod- and Host-Specific Borrelia burgdorferi bbk32 Expression and the Inhibition of Spirochete Transmission1 (2000) (119)
IL-18BP is a secreted immune checkpoint and barrier to IL-18 immunotherapy (2020) (119)
Distal Enhancer Elements Transcribe Intergenic RNA in the IL-10 Family Gene Cluster1 (2005) (119)
Constitutive homing of mast cell progenitors to the intestine depends on autologous expression of the chemokine receptor CXCR2. (2005) (118)
Roles of caspase-1 in Listeria infection in mice. (2004) (118)
Physiological Regulation of the β-Amyloid Precursor Protein Signaling Domain by c-Jun N-Terminal Kinase JNK3 during Neuronal Differentiation (2005) (117)
SHIP Represses the Generation of IL-3-Induced M2 Macrophages by Inhibiting IL-4 Production from Basophils1 (2009) (117)
Transcription of H‐2 and Qa genes in embryonic and adult mice. (1987) (117)
In vitro site-directed mutagenesis: generation and properties of an infectious extracistronic mutant of bacteriophage Qbeta. (1976) (116)
CD40L is important for induction of, but not response to, costimulatory activity. ICAM-1 as the second costimulatory molecule rapidly up-regulated by CD40L. (1996) (116)
Microbiota-driven interleukin-17-producing cells and eosinophils synergize to accelerate multiple myeloma progression (2018) (116)
Distinct modes of mitochondrial metabolism uncouple T cell differentiation and function (2019) (116)
A potential donor gene for the bm1 gene conversion event in the C57BL mouse (1983) (116)
Cutting Edge: Nucleotide-Binding Oligomerization Domain 1-Dependent Responses Account for Murine Resistance against Trypanosoma cruzi Infection (2009) (115)
Role of the Executioner Caspases during Lens Development* (2004) (115)
Tolerance in transgenic mice expressing major histocompatibility molecules extrathymically on pancreatic cells. (1990) (115)
TLR3 Is Essential for the Induction of Protective Immunity against Punta Toro Virus Infection by the Double-Stranded RNA (dsRNA), Poly(I:C12U), but not Poly(I:C): Differential Recognition of Synthetic dsRNA Molecules1 (2007) (115)
Activation of the p38 Mitogen-Activated Protein Kinase Pathway Arrests Cell Cycle Progression and Differentiation of Immature Thymocytes in Vivo (2000) (114)
Deficiency of Small Gtpase Rac2 Affects T Cell Activation (2001) (114)
MEKK4 Signaling Regulates Filamin Expression and Neuronal Migration (2006) (114)
Guanylate Binding Proteins Enable Rapid Activation of Canonical and Noncanonical Inflammasomes in Chlamydia-Infected Macrophages (2015) (113)
Blocking immunoinhibitory receptor LILRB2 reprograms tumor-associated myeloid cells and promotes antitumor immunity (2018) (113)
Apoptosome-Independent Activation of the Lysosomal Cell Death Pathway byCaspase-9 (2006) (113)
Humanized mouse model supports development, function, and tissue residency of human natural killer cells (2017) (111)
Regulation of c-Jun NH2-terminal Kinase ( Jnk) Gene Expression during T Cell Activation (2000) (111)
The nucleotide sequence of the murine I‐E beta b immune response gene: evidence for gene conversion events in class II genes of the major histocompatibility complex. (1984) (111)
The E3 ubiquitin ligase c-Cbl restricts development and functions of hematopoietic stem cells. (2008) (110)
The Ro Autoantigen Binds Misfolded U2 Small Nuclear RNAs and Assists Mammalian Cell Survival after UV Irradiation (2003) (110)
IL‐22 and inflammation: Leukin' through a glass onion (2008) (109)
A pathogenic role for T cell–derived IL-22BP in inflammatory bowel disease (2016) (109)
The CD40-CD154 system in anti-infective host defense. (1997) (109)
Inflammasomes and metabolic disease. (2014) (109)
Subsets of ILC3−ILC1-like cells generate a diversity spectrum of innate lymphoid cells in human mucosal tissues (2019) (109)
The Fire Within: Microbes Inflame Tumors (2014) (109)
Microenvironment-dependent growth of pre-neoplastic and malignant plasma cells in humanized mice (2016) (109)
RIG-I-mediated Activation of p38 MAPK Is Essential for Viral Induction of Interferon and Activation of Dendritic Cells (2009) (108)
Apoptosis genes and autoimmunity. (2000) (108)
Regulatory Role of B Cells in a Murine Model of Allergic Airway Disease1 (2008) (108)
COP9 signalosome subunit 8 is essential for peripheral T cell homeostasis and antigen receptor–induced entry into the cell cycle from quiescence (2007) (107)
Mitogen-activated protein kinase kinase 3 is a pivotal pathway regulating p38 activation in inflammatory arthritis. (2006) (107)
In Vivo Evidence for the Contribution of Human Histocompatibility Leukocyte Antigen (Hla)-Dq Molecules to the Development of Diabetes (2000) (107)
Regulator of Calcineurin 1 (RCAN1) Facilitates Neuronal Apoptosis through Caspase-3 Activation* (2011) (107)
A Novel Role for GADD45β as a Mediator of MMP-13 Gene Expression during Chondrocyte Terminal Differentiation* (2005) (107)
Long-term protection of mice from Lyme disease by vaccination with OspA (1992) (107)
Chronic murine colitis is dependent on the CD154/CD40 pathway and can be attenuated by anti-CD154 administration. (2000) (106)
The temporal importance of TNFalpha expression in the development of diabetes. (2000) (105)
MiR-125a targets effector programs to stabilize Treg-mediated immune homeostasis (2015) (105)
Activin A Promotes the TGF-β-Induced Conversion of CD4+CD25− T Cells into Foxp3+ Induced Regulatory T Cells 1 (2009) (105)
A scaffold protein, AHNAK1, is required for calcium signaling during T cell activation. (2008) (105)
Differential transcription directed by discrete gamma interferon promoter elements in naive and memory (effector) CD4 T cells and CD8 T cells (1997) (104)
GADD45β/GADD45γ and MEKK4 comprise a genetic pathway mediating STAT4‐independent IFNγ production in T cells (2004) (103)
Infertility in male transgenic mice: disruption of sperm development by HSV-tk expression in postmeiotic germ cells. (1990) (103)
Autocrine Secretion of Interferon γ Negatively Regulates Homing of Immature B Cells (2000) (102)
Requirement for CD40-CD40 Ligand Interaction for Elimination of Cryptosporidium parvum from Mice (1998) (102)
Chloroquine‐Induced Neuronal Cell Death Is p53 and Bcl‐2 Family‐Dependent But Caspase‐Independent (2001) (101)
Loss of mitogen-activated protein kinase kinase kinase 4 (MEKK4) results in enhanced apoptosis and defective neural tube development. (2005) (101)
Caspase‐3 is required for apoptosis‐associated DNA fragmentation but not for cell death in neurons deprived of potassium (2000) (101)
Transforming growth factor-beta: recent advances on its role in immune tolerance. (2006) (101)
Critical role for the β regulatory subunits of Cav channels in T lymphocyte function (2006) (100)
Double knockout of the MRP gene leads to increased drug sensitivity in vitro. (1996) (100)
Role of MKK3–p38 MAPK signalling in the development of type 2 diabetes and renal injury in obese db/db mice (2009) (100)
Autoimmune lpr/lpr mice deficient in CD40 ligand: spontaneous Ig class switching with dichotomy of autoantibody responses. (1996) (100)
Interchromosomal association and gene regulation in trans. (2010) (99)
The pattern recognition receptors Nod1 and Nod2 account for neutrophil recruitment to the lungs of mice infected with Legionella pneumophila. (2010) (99)
Topological Organization of Multi-chromosomal Regions by Firre (2014) (99)
Arthritogenic Properties of Double-Stranded (Viral) RNA1 (2004) (99)
Modulation of Cell Adhesion and Motility in the Immune System by Myo1f (2006) (99)
Interleukin 18 Restores Defective Th1 Immunity to Candida albicans in Caspase 1-Deficient Mice (2000) (98)
Antiviral Peptides Targeting the West Nile Virus Envelope Protein (2006) (98)
An Intrinsic Mechanism Predisposes Foxp3-Expressing Regulatory T Cells to Th2 Conversion In Vivo (2010) (98)
Transforming growth factor (TGF-) and autoimmunity (2005) (98)
Detrimental Contribution of the Immuno-Inhibitor B7-H1 to Rabies Virus Encephalitis1 (2008) (97)
Requirement of Mitogen-activated Protein Kinase Kinase 3 (MKK3) for Activation of p38α and p38δ MAPK Isoforms by TGF-β1 in Murine Mesangial Cells* (2002) (97)
FAT10/Diubiquitin-Like Protein-Deficient Mice Exhibit Minimal Phenotypic Differences (2006) (97)
IL-10 Signaling Blockade Controls Murine West Nile Virus Infection (2009) (97)
Duplicated gene pairs and alleles of class I genes in the Qa2 region of the murine major histocompatibility complex: a comparison. (1985) (97)
Endoplasmic Reticulum Stress-induced Death of Mouse Embryonic Fibroblasts Requires the Intrinsic Pathway of Apoptosis* (2007) (97)
JNK initiates a cytokine cascade that causes Pax2 expression and closure of the optic fissure. (2003) (96)
Localization of DNA sequences necessary for transcription of the rabbit β-globin gene in vitro (1981) (96)
The DNA Methylcytosine Dioxygenase Tet2 Sustains Immunosuppressive Function of Tumor‐Infiltrating Myeloid Cells to Promote Melanoma Progression (2017) (96)
c-Jun NH2-Terminal Kinase (JNK)1 and JNK2 Signaling Pathways Have Divergent Roles in CD8+ T Cell–mediated Antiviral Immunity (2002) (95)
Free Cholesterol-loaded Macrophages Are an Abundant Source of Tumor Necrosis Factor-α and Interleukin-6 (2005) (95)
Breeding progress and preparedness for mass‐scale deployment of perennial lignocellulosic biomass crops switchgrass, miscanthus, willow and poplar (2018) (95)
Adenosine is required for sustained inflammasome activation via the A2A receptor and the HIF-1α pathway (2013) (95)
Disruption of Myosin 1e promotes podocyte injury. (2009) (95)
NLRP3 deficiency protects from type 1 diabetes through the regulation of chemotaxis into the pancreatic islets (2015) (94)
Autocrine/paracrine TGF-β1 inhibits Langerhans cell migration (2012) (94)
Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis. (2003) (94)
Inhibition of NF-κB Activity and Enhancement of Apoptosis by the Neuropeptide Calcitonin Gene-related Peptide* (2000) (94)
Adoptive transfer of CD8+ T cells from transforming growth factor beta receptor type II (dominant negative form) induces autoimmune cholangitis in mice (2008) (94)
mRNA destabilization by BTG1 and BTG2 maintains T cell quiescence (2020) (93)
Interleukin-22 promotes fibroblast- mediated wound repair in the skin (2012) (93)
Transforming growth factor-beta signaling in t cells promotes stabilization of atherosclerotic plaques through an interleukin-17 dependent pathway (2014) (93)
Integrated src kinase and costimulatory activity enhances signal transduction through single-chain chimeric receptors in T lymphocytes. (2001) (93)
Structure of the human fetal globin gene locus (1979) (93)
Integrative inflammasome activity in the regulation of intestinal mucosal immune responses (2012) (92)
Contribution of Fas to diabetes development (2003) (92)
Innate Immune Cells in Inflammation and Cancer (2013) (92)
Glucocorticoids suppress inflammation via the upregulation of negative regulator IRAK-M (2015) (92)
JNK Regulates Autocrine Expression of TGF-β1 (2004) (92)
JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate (2012) (92)
Distinct Microbial Communities Trigger Colitis Development upon Intestinal Barrier Damage via Innate or Adaptive Immune Cells (2017) (91)
c-Jun NH2-terminal kinase 1 plays a critical role in intestinal homeostasis and tumor suppression. (2007) (91)
Serologic Diagnosis of Lyme Borreliosis by Using Enzyme-Linked Immunosorbent Assays with Recombinant Antigens (2000) (91)
A novel role for the major histocompatibility complex class II transactivator CIITA in the repression of IL-4 production. (1999) (91)
Deletion of the c-Jun N-terminal Kinase 3 Gene Protects Neonatal Mice against Cerebral Hypoxic—Ischaemic Injury (2007) (91)
Natural killer T cells exacerbate liver injury in a transforming growth factor β receptor II dominant‐negative mouse model of primary biliary cirrhosis (2007) (91)
Myeloid leukemia development in c-Cbl RING finger mutant mice is dependent on FLT3 signaling. (2010) (91)
The glycosyl phosphatidylinositol anchor is critical for Ly-6A/E- mediated T cell activation (1991) (90)
Partial destruction of Borrelia burgdorferi within ticks that engorged on OspE- or OspF-immunized mice (1994) (90)
The stumpy gene is required for mammalian ciliogenesis (2008) (90)
Inflammasome components Asc and caspase-1 mediate biomaterial-induced inflammation and foreign body response (2011) (89)
Borrelia burgdorferi strain 25015: characterization of outer surface protein A and vaccination against infection. (1992) (89)
The AHNAKs are a class of giant propeller-like proteins that associate with calcium channel proteins of cardiomyocytes and other cells (2004) (88)
Clonal deletion of V beta 5+ T cells by transgenic I-E restricted to thymic medullary epithelium. (1993) (88)
Deletion of interleukin (IL)‐12p35 induces liver fibrosis in dominant‐negative TGFβ receptor type II mice (2013) (88)
NLRC4/IPAF: a CARD carrying member of the NLR family. (2009) (88)
Shielding the double‐edged sword: negative regulation of the innate immune system (2004) (88)
The light and the dark sides of Interleukin-10 in immune-mediated diseases and cancer. (2016) (88)
IL-22 Signaling Contributes to West Nile Encephalitis Pathogenesis (2012) (87)
Sera from patients with chronic Lyme disease protect mice from Lyme borreliosis. (1994) (87)
IL9 leads to airway inflammation by inducing IL13 expression in airway epithelial cells. (2006) (87)
HSP70 enhances macrophage phagocytosis by interaction with lipid raft-associated TLR-7 and upregulating p38 MAPK and PI3K pathways. (2006) (87)
Apoptosis is not required for mammalian neural tube closure (2009) (87)
Reconstitution of invariant chain function in transgenic mice in vivo by individual p31 and p41 isoforms. (1995) (87)
Caspase-3 Is a Pivotal Mediator of Apoptosis during Regression of the Ovarian Corpus Luteum. (2002) (87)
Morphogenesis of the telencephalic commissure requires scaffold protein JNK-interacting protein 3 (JIP3) (2003) (86)
Molecular mapping of Osp-A mediated immunity against Borrelia burgdorferi, the agent of Lyme disease. (1991) (86)
Alternative activation of macrophages by IL‐4 requires SHIP degradation (2011) (85)
Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes. (2005) (85)
ASC/PYCARD and Caspase-1 Regulate the IL-18/IFN-γ Axis during Anaplasma phagocytophilum Infection1 (2007) (84)
NALP3: a key player in caspase-1 activation (2006) (84)
Enteric Nervous System-Derived IL-18 Orchestrates Mucosal Barrier Immunity (2020) (84)
Lymph Node Germinal Centers Form in the Absence of Follicular Dendritic Cell Networks (1999) (84)
Role of T cell TGF‐β signaling in intestinal cytokine responses and helminthic immune modulation (2009) (84)
Compensatory Anion Currents in Kv1.3 Channel-deficient Thymocytes* (2003) (84)
Oxidative metabolism enables Salmonella evasion of the NLRP3 inflammasome (2014) (83)
IL-10 Suppression of NK/DC Crosstalk Leads to Poor Priming of MCMV-Specific CD4 T Cells and Prolonged MCMV Persistence (2012) (83)
The E3 ligase Itch is a negative regulator of the homeostasis and function of hematopoietic stem cells (2011) (83)
Mechanisms of immune tolerance induction through the thymic expression of a peripheral tissue-specific protein. (1995) (82)
JNK2 and JNK3 combined are essential for apoptosis in dopamine neurons of the substantia nigra, but are not required for axon degeneration (2008) (82)
Role of Caspase‐1 in experimental pneumococcal meningitis: Evidence from pharmacologic Caspase inhibition and Caspase‐1‐deficient mice (2002) (82)
The E3 ligase Itch and deubiquitinase Cyld co-operatively regulate Tak1 and inflammation (2011) (82)
JNK1 Is Required for T Cell-Mediated Immunity Against Leishmania major Infection1 (2000) (81)
Borrelia burgdorferi-infected, interleukin-6-deficient mice have decreased Th2 responses and increased lyme arthritis. (1998) (81)
Th2 LCR is essential for regulation of Th2 cytokine genes and for pathogenesis of allergic asthma (2010) (81)
The Role of Lymphocyte Subsets in Accelerated Diabetes in Nonobese Diabetic–Rat Insulin Promoter–B7-1 (NOD-RIP-B7-1) Mice (1998) (81)
Regulation of the activity of IFN-gamma promoter elements during Th cell differentiation. (1998) (80)
Plexin-B1 plays a redundant role during mouse development and in tumour angiogenesis (2007) (80)
Excessive Th1 responses due to the absence of TGF-β signaling cause autoimmune diabetes and dysregulated Treg cell homeostasis (2013) (80)
Effector TH17 Cells Give Rise to Long-Lived TRM Cells that Are Essential for an Immediate Response against Bacterial Infection (2019) (80)
Use of recombinant antigens of Borrelia burgdorferi in serologic tests for diagnosis of lyme borreliosis (1996) (79)
IL-9 Regulates Allergen-Specific Th1 Responses in Allergic Contact Dermatitis (2014) (79)
Regulated expression of the human β-globin gene family in murine erythroleukaemia cells (1983) (79)
Pancreatic infiltration but not diabetes occurs in the relative absence of MHC class II-restricted CD4 T cells: studies using NOD/CIITA-deficient mice. (1999) (79)
Bcl-XL–Caspase-9 Interactions in the Developing Nervous System: Evidence for Multiple Death Pathways (2001) (78)
The c-Jun NH2-terminal kinase is essential for epidermal growth factor expression during epidermal morphogenesis. (2004) (78)
Endophytic bacteria in Miscanthus seed: implications for germination, vertical inheritance of endophytes, plant evolution and breeding (2017) (78)
JNK3 contributes to c‐Jun activation and apoptosis but not oxidative stress in nerve growth factor‐deprived sympathetic neurons (2001) (78)
CIITA activates the expression of MHC class II genes in mouse T cells. (1995) (78)
Neonatal Tumor Necrosis Factor α Promotes Diabetes in Nonobese Diabetic Mice by Cd154-Independent Antigen Presentation to Cd8+ T Cells (2000) (78)
Acetylation of MKP-1 and the Control of Inflammation (2008) (78)
A novel humanized mouse model with significant improvement of class-switched, antigen-specific antibody production. (2017) (78)
Deleterious role of TLR3 during hyperoxia-induced acute lung injury. (2008) (77)
SEK1/MKK4 is required for maintenance of a normal peripheral lymphoid compartment but not for lymphocyte development. (1998) (77)
Protective antibodies in murine Lyme disease arise independently of CD40 ligand. (1996) (77)
Regulation of AP-1 and NFAT transcription factors during thymic selection of T cells (1996) (77)
B cells suppress the inflammatory response in a mouse model of primary biliary cirrhosis. (2009) (77)
Naturally Activated Vγ4 γδ T Cells Play a Protective Role in Tumor Immunity through Expression of Eomesodermin (2010) (77)
ZEB1, ZEB2, and the miR-200 family form a counterregulatory network to regulate CD8+ T cell fates (2018) (77)
E3 ubiquitin ligase GRAIL controls primary T cell activation and oral tolerance (2009) (77)
Apoptosis in response to microbial infection induces autoreactive TH17 cells (2016) (76)
The role of NOD-like Receptors in shaping adaptive immunity. (2010) (76)
Enhancement of IFNγ Production by Distinct Commensals Ameliorates Salmonella-Induced Disease. (2017) (76)
IL-10 Receptor Signaling Is Essential for TR1 Cell Function In Vivo (2017) (76)
Signaling by the JNK Group of MAP Kinases (2001) (75)
T-cell responsiveness to an oncogenic peripheral protein and spontaneous autoimmunity in transgenic mice. (1992) (75)
Plasmacytoid dendritic cells are productively infected and activated through TLR-7 early after arenavirus infection. (2012) (75)
Expression of the Co-stimulator Molecule B7–1 in Pancreatic β-Cells Accelerates Diabetes in the NOD Mouse (1995) (75)
B7 costimulation is necessary for the activation of the lytic function in cytotoxic T lymphocyte precursors. (1995) (74)
A Role for Tumor Necrosis Factor Receptor Type 1 in Gut-associated Lymphoid Tissue Development: Genetic Evidence of Synergism with Lymphotoxin β (1998) (74)
c-Jun NH 2-Terminal Kinase ( JNK ) 1 and JNK 2 Have Distinct Roles in CD 8 T Cell Activation (2002) (74)
DNA methylation in the human gamma delta beta-globin locus in erythroid and nonerythroid tissues. (1980) (73)
Demethylation of a specific hypersensitive site in the Th2 locus control region (2007) (73)
Regulatory T Cells, Transforming Growth Factor–β, and Immune Suppression (2007) (73)
The sympathetic nervous system modulates CD4+FoxP3+ regulatory T cells via a TGF‐β‐dependent mechanism (2009) (73)
ABC transporters and NR4A1 identify a quiescent subset of tissue-resident memory T cells. (2016) (73)
Emerging Roles of L-Type Voltage-Gated and Other Calcium Channels in T Lymphocytes (2013) (72)
alpha beta T cell regulation and CD40 ligand dependence in murine systemic autoimmunity. (1997) (72)
CD62L is required on effector cells for local interactions in the CNS to cause myelin damage in experimental allergic encephalomyelitis. (2001) (72)
IL-1 receptor–associated kinase M is a central regulator of osteoclast differentiation and activation (2005) (72)
Glioma-induced inhibition of caspase-3 in microglia promotes a tumor-supportive phenotype (2016) (72)
Teplizumab Induces Human Gut-Tropic Regulatory Cells in Humanized Mice and Patients (2012) (72)
Skin-resident innate lymphoid cells converge on a pathogenic effector state (2021) (72)
Toll-like receptor 7 is required for effective adaptive immune responses that prevent persistent virus infection. (2012) (72)
The Role of Toll‐Like Receptors 3 and 9 in the Development of Autoimmune Diabetes in NOD Mice (2008) (71)
Multiple MyD88‐dependent responses contribute to pulmonary clearance of Legionella pneumophila (2009) (71)
TRANCE–RANK, a New Signal Pathway Involved in Lymphocyte Development and T Cell Activation (1999) (71)
Adenosine metabolism and murine strain-specific IL-4-induced inflammation, emphysema, and fibrosis. (2006) (71)
Identification of the region on the class I histocompatibility molecule that interacts with the molecular chaperone, p88 (calnexin, IP90). (1993) (70)
Molecular and functional heterogeneity of IL-10-producing CD4+ T cells (2018) (70)
The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity (2016) (70)
T-cell tolerance and autoimmunity in transgenic models of central and peripheral tolerance. (1994) (70)
Lymphotoxin-β-deficient mice show defective antiviral immunity (1999) (70)
JNK3 Mediates Paraquat- and Rotenone-Induced Dopaminergic Neuron Death (2010) (69)
Vγ4 γδ T Cell-Derived IL-17A Negatively Regulates NKT Cell Function in Con A-Induced Fulminant Hepatitis (2011) (69)
Coincidental loss of DOCK8 function in NLRP10-deficient and C3H/HeJ mice results in defective dendritic cell migration (2015) (69)
Bax, caspase-2, and caspase-3 are required for ovarian follicle loss caused by 4-vinylcyclohexene diepoxide exposure of female mice in vivo. (2003) (69)
Death of a Monopoly? (2001) (69)
Site-directed mutagenesis: Generation of an extracistronic mutation in bacteriophage Qβ RNA (1974) (68)
ZPR1 Is Essential for Survival and Is Required for Localization of the Survival Motor Neurons (SMN) Protein to Cajal Bodies (2005) (68)
Abrogated transforming growth factor beta receptor II (TGFβRII) signalling in dendritic cells promotes immune reactivity of T cells resulting in enhanced atherosclerosis. (2013) (68)
Jak1 Expression Is Required for Mediating Interleukin-4-induced Tyrosine Phosphorylation of Insulin Receptor Substrate and Stat6 Signaling Molecules* (1997) (67)
Helper Requirements for Generation of Effector CTL to Islet β Cell Antigens1 (2004) (67)
m6A Modification Prevents Formation of Endogenous Double-Stranded RNAs and Deleterious Innate Immune Responses during Hematopoietic Development. (2020) (67)
Tumor necrosis factor‐a and the progression of diabetes in non‐obese diabetic mice (1999) (67)
Life, death, and miracles: Th17 cells in the intestine (2012) (67)
Amino‐termini isoforms of the Slack K+ channel, regulated by alternative promoters, differentially modulate rhythmic firing and adaptation (2008) (67)
The Presumptive Phosphatidylserine Receptor Is Dispensable for Innate Anti-inflammatory Recognition and Clearance of Apoptotic Cells* (2006) (67)
Kinetic analysis of genomewide gene expression reveals molecule circuitries that control T cell activation and Th1/2 differentiation. (2004) (67)
NLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease (2018) (66)
The complete nucleotide sequence of the I-E alpha d immune response gene. (1983) (66)
Immunity, microbiota and kidney disease (2019) (66)
IQGAP1 Is Important for Activation of Caspase-1 in Macrophages and Is Targeted by Yersinia pestis Type III Effector YopM (2014) (65)
Beta-globin gene inactivation by DNA translocation in gamma beta-thalassaemia. (1983) (65)
Essential Role of Lymph Nodes in Contact Hypersensitivity Revealed in Lymphotoxin-α–Deficient Mice (2001) (65)
Follicular Dendritic Cells and Dissemination of Creutzfeldt-Jakob Disease (2000) (65)
Divergent Effects of miR‐181 Family Members on Myocardial Function Through Protective Cytosolic and Detrimental Mitochondrial microRNA Targets (2017) (64)
Cutting Edge: Regulation of T Cell Trafficking and Primary Immune Responses by Sphingosine 1-Phosphate Receptor 1 (2005) (64)
Functional Cooperation of the Proapoptotic Bcl2 Family Proteins Bmf and Bim In Vivo (2009) (64)
Transcriptional activation of HLA-DR alpha by interferon gamma requires a trans-acting protein. (1988) (64)
A physical map of the DNA regions flanking the rabbit beta-globin gene. (1977) (64)
Induction of insulitis by glutamic acid decarboxylase peptide-specific and HLA-DQ8-restricted CD4(+) T cells from human DQ transgenic mice. (1998) (63)
Local production of human IL-6 promotes insulitis but retards the onset of insulin-dependent diabetes mellitus in non-obese diabetic mice. (1994) (63)
Evasion of protective immunity by Borrelia burgdorferi by truncation of outer surface protein B. (1993) (63)
Generation of Genetically Modified Mice Using the CRISPR-Cas9 Genome-Editing System. (2016) (63)
The sequence GGCmCGG is resistant to MspI cleavage. (1983) (63)
T-cell subsets: transcriptional control in the Th1/Th2 decision. (1997) (63)
Notch controls the magnitude of T helper cell responses by promoting cellular longevity (2012) (63)
Pancreatic islet expression of chemokine CCL2 suppresses autoimmune diabetes via tolerogenic CD11c+ CD11b+ dendritic cells (2012) (62)
Protective antibodies develop, and murine Lyme arthritis regresses, in the absence of MHC class II and CD4+ T cells. (1997) (62)
Transgenic mice which overproduce Th2 cytokines develop spontaneous atopic dermatitis and asthma. (2004) (62)
Improved regenerative myogenesis and muscular dystrophy in mice lacking Mkp5. (2013) (61)
Expression of transgene encoded TGF-beta in islets prevents autoimmune diabetes in NOD mice by a local mechanism. (2002) (61)
The activation of major histocompatibility complex class I genes by interferon regulatory factor-1 (IRF-1) (2004) (61)
Intestinal type 1 regulatory T cells migrate to periphery to suppress diabetogenic T cells and prevent diabetes development (2017) (61)
Transforming growth factor-β: Recent advances on its role in immune tolerance (2006) (61)
Widespread expression of an autoantigen-GAD65 transgene does not tolerize non-obese diabetic mice and can exacerbate disease. (1998) (60)
Characterization of Autoinducer-3 Structure and Biosynthesis in E. coli (2020) (59)
Rapid induction of a novel costimulatory activity on B cells by CD40 ligand (1995) (59)
Cutting Edge: Nlrp10 Is Essential for Protective Antifungal Adaptive Immunity against Candida albicans (2012) (59)
AIM2 Engages Active but Unprocessed Caspase-1 to Induce Noncanonical Activation of the NLRP3 Inflammasome. (2017) (59)
Selective degradation of PU.1 during autophagy represses the differentiation and antitumour activity of TH9 cells (2017) (59)
TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer (2020) (59)
Human Exposure to a Granulocytic Ehrlichia and Other Tick-Borne Agents in Connecticut (1998) (58)
Pooled CRISPR screening identifies m6A as a positive regulator of macrophage activation (2021) (58)
Conversion of a PI-anchored protein to an integral membrane protein by a single amino acid mutation. (1988) (58)
The role of CTCF in regulating nuclear organization (2008) (58)
Infiltration of CD 4 + lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease (2018) (58)
Activation of p38 mitogen-activated protein kinase contributes to the early cardiodepressant action of tumor necrosis factor. (2006) (58)
Tissue-resident memory T cell reactivation by diverse antigen-presenting cells imparts distinct functional responses (2020) (58)
Peripheral blood CD34+ cells efficiently engraft human cytokine knock-in mice. (2016) (58)
Shaping of Intestinal Microbiota in Nlrp6- and Rag2-Deficient Mice Depends on Community Structure. (2017) (58)
β‐Catenin mediates tumor‐induced immunosuppression by inhibiting cross‐priming of CD8+ T cells (2014) (57)
Borrelia burgdorferi erpT expression in the arthropod vector and murine host (1999) (57)
GADD45beta/GADD45gamma and MEKK4 comprise a genetic pathway mediating STAT4-independent IFNgamma production in T cells. (2004) (57)
Transforming growth factor beta (TGF-beta) and autoimmunity. (2005) (57)
Natural killer T cells exacerbate liver injury in a transforming growth factor beta receptor II dominant-negative mouse model of primary biliary cirrhosis. (2008) (56)
Tissue-specific expression of cell-surface Qa-2 antigen from a transfected Q7b gene of C57BL/10 mice (1987) (56)
Cooperation between Multiple Microbial Pattern Recognition Systems Is Important for Host Protection against the Intracellular Pathogen Legionella pneumophila (2010) (56)
Tissue‐specific, inducible and functional expression of the E alpha d MHC class II gene in transgenic mice. (1985) (56)
Drak2 Contributes to West Nile Virus Entry into the Brain and Lethal Encephalitis1 (2008) (55)
Physical mapping of the globin gene deletion in (δβ)° - thalassaemia (1979) (55)
Interleukin-17A Promotes CD8+ T Cell Cytotoxicity To Facilitate West Nile Virus Clearance (2016) (55)
Uncoupling of Airway Inflammation and Bronchial Hyperreactivity (1994) (54)
The intestinal microbiota in chronic liver disease. (2013) (54)
A non‐redundant role for MKP5 in limiting ROS production and preventing LPS‐induced vascular injury (2009) (54)
Gadd45β and Gadd45γ are critical for regulating autoimmunity (2005) (54)
Polyethyleneimine is a potent systemic adjuvant for glycoprotein antigens. (2014) (54)
Lymphotoxin-α- and Lymphotoxin-β-Deficient Mice Differ in Susceptibility to Scrapie: Evidence against Dendritic Cell Involvement in Neuroinvasion (2002) (54)
Group 1 Innate Lymphoid Cell Lineage Identity Is Determined by a cis-Regulatory Element Marked by a Long Non-coding RNA. (2017) (54)
The structure of the human -globin gene in -thalassaemia (1979) (53)
Caspase-3 is a pivotal mediator of apoptosis during regression of the ovarian corpus luteum. (2002) (53)
Murine autoimmune cholangitis requires two hits: cytotoxic KLRG1(+) CD8 effector cells and defective T regulatory cells. (2014) (53)
Up-Regulation of Hlx in Immature Th Cells Induces IFN-γ Expression1 (2004) (53)
Immunologic nonresponsiveness to tumors. (1998) (53)
Phase separation drives RNA virus-induced activation of the NLRP6 inflammasome (2021) (53)
The TCR zeta-chain immunoreceptor tyrosine-based activation motifs are sufficient for the activation and differentiation of primary T lymphocytes. (1999) (53)
Intestinal IFN‐&ggr;–producing type 1 regulatory T cells coexpress CCR5 and programmed cell death protein 1 and downregulate IL‐10 in the inflamed guts of patients with inflammatory bowel disease (2018) (53)
Transforming Growth Factor-β Suppresses the Activation of CD8+ T-Cells When Naïve but Promotes Their Survival and Function Once Antigen Experienced (2008) (52)
Nuclear Receptor CAR Represses TNFα-Induced Cell Death by Interacting with the Anti-Apoptotic GADD45B (2010) (52)
Disruption of TGF-β Signaling Improves Ocular Surface Epithelial Disease in Experimental Autoimmune Keratoconjunctivitis Sicca (2011) (52)
Correction: Malarial Hemozoin Activates the NLRP3 Inflammasome through Lyn and Syk Kinases (2009) (52)
miR-181b regulates vascular stiffness age dependently in part by regulating TGF-β signaling (2017) (52)
Extended lifespan and reduced adiposity in mice lacking the FAT10 gene (2014) (52)
Abstract 5395: The E3 ligase Itch and deubiquitinase Cyld act together to regulate Tak1 and inflammation (2012) (51)
Eukaryotic genes. Their structure, activity and regulation. (1983) (51)
Myosin I: From yeast to human (2008) (51)
MKK3-p38 signaling promotes apoptosis and the early inflammatory response in the obstructed mouse kidney. (2007) (51)
Requirement for AHNAK1-mediated calcium signaling during T lymphocyte cytolysis (2009) (51)
Epigenetic and Transcriptional Programs Lead to Default IFN-γ Production by γδ T Cells1 (2007) (51)
Molecular mapping of signals in the Qa-2 antigen required for attachment of the phosphatidylinositol membrane anchor. (1988) (51)
Deficiency of the zinc finger protein ZPR1 causes neurodegeneration. (2006) (51)
Toll-Like Receptors Induce Signal-Specific Reprogramming of the Macrophage Lipidome. (2020) (51)
Regulatory T cells, transforming growth factor-beta, and immune suppression. (2007) (51)
Targeting autoantigen-specific T cells and suppression of autoimmune encephalomyelitis with receptor-modified T lymphocytes (2002) (51)
CORRELATION OF FETAL KIDNEY AND TESTIS CONGENIC GRAFT SURVIVAL WITH REDUCED MAJOR HISTOCOMPATIBILITY COMPLEX BURDEN (1989) (50)
Chimeric receptor mRNA transfection as a tool to generate antineoplastic lymphocytes. (2008) (50)
ICOS Mediates the Development of Insulin-Dependent Diabetes Mellitus in Nonobese Diabetic Mice1 (2008) (50)
Vaccination against Lyme disease caused by diverse Borrelia burgdorferi (1995) (50)
m6A demethylase ALKBH5 controls CD4+ T cell pathogenicity and promotes autoimmunity (2021) (50)
Targeted expression of the neuropeptide calcitonin gene-related peptide to beta cells prevents diabetes in NOD mice. (1997) (50)
Tyrosine phosphorylation of SHIP promotes its proteasomal degradation. (2010) (49)
Microbiota Normalization Reveals that Canonical Caspase-1 Activation Exacerbates Chemically Induced Intestinal Inflammation. (2017) (49)
OspB Antibody Prevents Borrelia burgdorferi Colonization of Ixodes scapularis (2004) (49)
Interaction of the c-Jun/JNK Pathway and Cyclin-dependent Kinases in Death of Embryonic Cortical Neurons Evoked by DNA Damage* (2002) (49)
Nonspecific proliferative responses of murine lymphocytes to Borrelia burgdorferi antigens. (1992) (49)
miR‐181a/b downregulation exerts a protective action on mitochondrial disease models (2019) (49)
A highly efficient and faithful MDS patient-derived xenotransplantation model for pre-clinical studies (2018) (49)
The Firre locus produces a trans-acting RNA molecule that functions in hematopoiesis (2019) (49)
Immunological Tolerance to a Pancreatic Antigen as a Result of Local Expression of TNFα by Islet β Cells (1997) (49)
Serologic diagnosis of Lyme disease using recombinant outer surface proteins A and B and flagellin. (1992) (49)
Breaking immunologic ignorance to an antigenic peptide of simian virus 40 large T antigen. (1995) (49)
Map kinase phosphatase 5 protects against sepsis-induced acute lung injury. (2012) (49)
Sequence requirements for the transcription of the rabbit β-globin gene in vivo: -80 region (1982) (49)
Macrophage and T Cell Produced IL-10 Promotes Viral Chronicity (2013) (48)
IRAK-M Promotes Alternative Macrophage Activation and Fibroproliferation in Bleomycin-Induced Lung Injury (2015) (48)
Interleukin-1 receptor and caspase-1 are required for the Th17 response in nitrogen dioxide-promoted allergic airway disease. (2013) (48)
Nlrp3 Prevents Early Renal Interstitial Edema and Vascular Permeability in Unilateral Ureteral Obstruction (2014) (48)
Inflammasome-mediated suppression of inflammation-induced colorectal cancer progression is mediated by direct regulation of epithelial cell proliferation (2011) (48)
AMCase is a crucial regulator of type 2 immune responses to inhaled house dust mites (2015) (48)
DNA‐DNA Hybridization on Nitrocellulose Filters (1974) (48)
The DNA sequence of the 5' flanking region of the human beta-globin gene: evolutionary conservation and polymorphic differences. (1982) (48)
Glutamic acid decarboxylase T lymphocyte responses associated with susceptibility or resistance to type I diabetes: analysis in disease discordant human twins, non-obese diabetic mice and HLA-DQ transgenic mice. (1998) (48)
Harnessing the power of regulatory T‐cells to control autoimmune diabetes: overview and perspective (2018) (48)
Inflammasome activation mediates inflammation and outcome in humans and mice with pneumococcal meningitis (2013) (48)
ICOS Controls Effector Function but Not Trafficking Receptor Expression of Kidney-Infiltrating Effector T Cells in Murine Lupus1 (2009) (48)
Rotavirus VP3 targets MAVS for degradation to inhibit type III interferon expression in intestinal epithelial cells (2018) (47)
Differential expression of Borrelia burgdorferi genes during erythema migrans and Lyme arthritis. (1998) (47)
Protection of mice from Lyme borreliosis by oral vaccination with Escherichia coli expressing OspA. (1991) (47)
A Monoclonal Antibody to OspA Inhibits Association of Borrelia burgdorferi with Human Endothelial Cells (1993) (47)
Autocrine/paracrine TGFb1 is required for the development of epidermal Langerhans cells (2007) (47)
Role of cathepsin S-dependent epithelial cell apoptosis in IFN-γ-induced alveolar remodeling and pulmonary emphysema (2005) (47)
Expression of murine H-2Kb histocompatibility antigen in cells transformed with cloned H-2 genes. (1982) (47)
Dissection of the interferon gamma‐MHC class II signal transduction pathway reveals that type I and type II interferon systems share common signalling component(s). (1992) (46)
Local IL-4 expression in the lung reduces pulmonary influenza-virus-specific secondary cytotoxic T cell responses. (2000) (46)
Acidic Mammalian Chitinase Regulates Epithelial Cell Apoptosis via a Chitinolytic-Independent Mechanism (2009) (46)
A Role for IL-1 Receptor-Associated Kinase-M in Prostaglandin E2-Induced Immunosuppression Post-Bone Marrow Transplantation (2010) (46)
Control of T Helper Cell Differentiation--in Search of Master Genes (2000) (46)
The emerging role of Janus kinase inhibitors in the treatment of autoimmune and inflammatory diseases. (2020) (45)
The selective ablation of interleukin 2-producing cells isolated from transgenic mice (1993) (45)
Detection of differentially abundant cell subpopulations in scRNA-seq data (2021) (45)
Oct-1 regulates IL-17 expression by directing interchromosomal associations in conjunction with CTCF in T cells. (2014) (45)
CD154 Is Essential for Protective Immunity in Experimental Salmonella Infection: Evidence for a Dual Role in Innate and Adaptive Immune Responses1 (2006) (45)
TGF-β signaling is required for the function of insulin-reactive T regulatory cells (2006) (45)
OspA vaccination of mice with established Borrelia burgdorferi infection alters disease but not infection (1993) (45)
Multiple mechanisms regulate the expression of murine immune response genes (1985) (45)
Regulatory T cell-derived IL-10 ameliorates crescentic GN. (2013) (45)
Deubiquitination of NLRP6 inflammasome by Cyld critically regulates intestinal inflammation (2020) (45)
Membrane-cytoskeletal crosstalk mediated by myosin-I regulates adhesion turnover during phagocytosis (2019) (45)
NF-κB-Inducing Kinase Regulates Selected Gene Expression in the Nod2 Signaling Pathway (2006) (45)
YY1 inhibits differentiation and function of regulatory T cells by blocking Foxp3 expression and activity (2016) (44)
Gatekeeper role of brain antigen‐presenting CD11c+ cells in neuroinflammation (2016) (44)
METTL3-mediated m6A RNA methylation promotes the anti-tumour immunity of natural killer cells (2021) (44)
Dynamin 2-dependent endocytosis sustains T-cell receptor signaling and drives metabolic reprogramming in T lymphocytes (2015) (44)
The molecular basis of T cell differentiation (1999) (44)
A crucial role of caspase-3 in osteogenic differentiation of bone marrow stromal stem cells (2004) (44)
Invariant Chain Controls H2-M Proteolysis in Mouse Splenocytes and Dendritic Cells (2000) (44)
Preferential Th1 Immune Response in Invariant Chain-Deficient Mice1 (2002) (44)
Regulated expression of an introduced MHC H–2Kbm1 gene in murine embryonal carcinoma cells (1984) (44)
c-Jun N-terminal Kinase 3 Deficiency Protects Neurons from Axotomy-induced Death in Vivo through Mechanisms Independent of c-Jun Phosphorylation* (2005) (44)
Interaction between Kb and Q4 gene sequences generates the Kbm6 mutation (1986) (44)
Dendritic cell-mediated activation-induced cytidine deaminase (AID)-dependent induction of genomic instability in human myeloma. (2012) (43)
Mechanism of Transforming Growth Factor (cid:2) –induced Inhibition of T Helper Type 1 Differentiation (2002) (43)
Requirement of JIP scaffold proteins for NMDA-mediated signal transduction. (2007) (43)
Epigenetic and transcriptional programs lead to default IFN-gamma production by gammadelta T cells. (2007) (43)
The initiation of autoimmune diabetes. (1999) (43)
JNK regulates autocrine expression of TGF-beta1. (2004) (43)
Protection against antigenically variable Borrelia burgdorferi conferred by recombinant vaccines (1993) (43)
Abnormal cellular localization of thyroglobulin mRNA associated with hereditary congenital goiter and thyroglobulin deficiency. (1978) (43)
Positive Signaling Through CD72 Induces Mitogen-Activated Protein Kinase Activation and Synergizes with B Cell Receptor Signals to Induce X-Linked Immunodeficiency B Cell Proliferation1 (2001) (43)
Epithelial endoplasmic reticulum stress orchestrates a protective IgA response (2019) (42)
Rabies Virus Is Recognized by the NLRP3 Inflammasome and Activates Interleukin-1β Release in Murine Dendritic Cells (2013) (42)
The transcription cofactor Hopx is required for regulatory T cell function in dendritic cell–mediated peripheral T cell unresponsiveness (2010) (42)
Novel Borrelia burgdorferi isolates from Ixodes scapularis and Ixodes dentatus ticks feeding on humans (1996) (42)
ICOS is essential for the development of experimental autoimmune myasthenia gravis (2004) (42)
Activation of NF-kappaB promotes the transition of large, CD43+ pre-B cells to small, CD43- pre-B cells. (2005) (42)
Caspase 6 Regulates B Cell Activation and Differentiation into Plasma Cells1 (2008) (41)
Helper requirements for generation of effector CTL to islet beta cell antigens. (2004) (41)
Isolation of transforming DNA by cosmid rescue. (1982) (41)
Serologic diagnosis of canine and equine borreliosis: use of recombinant antigens in enzyme-linked immunosorbent assays (1997) (41)
Apoptosis. Death of a monopoly? (2001) (41)
Transplant Tolerance to Pancreatic Islets Is Initiated in the Graft and Sustained in the Spleen (2013) (41)
Molecular analysis of antigen recognition by insulin-specific T-cell hybridomas from B6 wild-type and bm12 mutant mice (1987) (41)
NOD2, the gene responsible for familial granulomatous uveitis, in a mouse model of uveitis. (2008) (41)
Carrier‐mediated enhancement of cognate T cell help: the basis for enhanced immunogenicity of meningococcal outer membrane protein polysaccharide conjugate vaccine (2001) (41)
The unusual properties of mtDNA from a "low-density" petite mutant of yeast. (1972) (41)
Yeast mitochondrial RNA does not contain poly(A) (1974) (41)
Loss of Mcl-1 Protein and Inhibition of Electron Transport Chain Together Induce Anoxic Cell Death (2006) (41)
Serologic response to the Borrelia burgdorferi flagellin demonstrates an epitope common to a neuroblastoma cell line. (1993) (40)
RIP2 contributes to Nod signaling but is not essential for T cell proliferation, T helper differentiation or TLR responses (2008) (40)
Inflammasomes and intestinal homeostasis: regulating and connecting infection, inflammation and the microbiota. (2014) (40)
DNA methylation and the regulation of globin gene expression. (1983) (40)
The relationship of inflammation and initiation of autoimmune disease: role of TNF super family members. (2002) (40)
Oral vaccination with an attenuated Salmonella typhimurium strain expressing Borrelia burgdorferi OspA prevents murine Lyme borreliosis (1995) (40)
Role of MAPK Kinase 6 in Arthritis: Distinct Mechanism of Action in Inflammation and Cytokine Expression1 (2009) (40)
Defective Survival of Naive CD8+ T Lymphocytes in the absence of β3 regulatory subunit of Cav channels (2009) (40)
Antivirulence properties of an antifreeze protein. (2014) (40)
inv(16) and NPM1mut AMLs engraft human cytokine knock-in mice. (2016) (39)
Direct physical interaction involving CD40 ligand on T cells and CD40 on B cells is required to propagate MMTV. (1995) (39)
Murine Lyme Arthritis Development Mediated by p38 Mitogen-Activated Protein Kinase Activity1 (2002) (39)
Executioner Caspase-3 and 7 Deficiency Reduces Myocyte Number in the Developing Mouse Heart (2015) (39)
Conservation and diversity in the class I genes of the major histocompatibility complex: sequence analysis of a Tlab gene and comparison with a Tlac gene. (1986) (39)
Truncated Form of TGF-βRII, But Not Its Absence, Induces Memory CD8+ T Cell Expansion and Lymphoproliferative Disorder in Mice (2013) (39)
Roles of Cav channels and AHNAK1 in T cells: the beauty and the beast (2009) (39)
Mitochondrial deoxyribonucleic acid from Tetrahymena pyriformis and its kinetic complexity. (1970) (39)
Innate Immunity and Apoptosis in IBD (2004) (39)
Inhibition of NF-kappaB activity and enhancement of apoptosis by the neuropeptide calcitonin gene-related peptide. (2000) (39)
Structure of the human G gamma-A gamma-delta-beta-globin gene locus. (1979) (39)
Overexpression of IL-7Rα provides a competitive advantage during early T-cell development (2004) (39)
JNK1 Is Essential for CD8+ T Cell-Mediated Tumor Immune Surveillance1 (2005) (39)
T-cell TGF-β signaling abrogation restricts medulloblastoma progression (2014) (38)
IRF8-dependent molecular complexes control the Th9 transcriptional program (2017) (38)
Prostaglandin F2alpha- and FAS-activating antibody-induced regression of the corpus luteum involves caspase-8 and is defective in caspase-3 deficient mice (2003) (38)
Structure and expression of a cloned beta o thalassaemic globin gene. (1981) (38)
Do T cells care about the mitogen‐activated protein kinase signalling pathways? (2000) (38)
Dynamin 2–dependent endocytosis is required for sustained S1PR1 signaling (2014) (38)
Secretion of a soluble class I molecule encoded by the Q10 gene of the C57BL/10 mouse. (1985) (37)
Inability of truncated recombinant Osp A proteins to elicit protective immunity to Borrelia burgdorferi in mice. (1993) (37)
miR-181 and metabolic regulation in the immune system. (2013) (37)
Zero-preserving imputation of single-cell RNA-seq data (2022) (37)
Specific molecular interaction between the insulin receptor and a D product of MHC class I. (1989) (37)
Prenatal acetaminophen affects maternal immune and endocrine adaptation to pregnancy, induces placental damage, and impairs fetal development in mice. (2015) (37)
Antigen presentation on artificial acellular substrates: modular systems for flexible, adaptable immunotherapy. (2009) (37)
A humanized mouse model of chronic COVID-19 (2021) (37)
IL-10-producing forkhead box protein 3-negative regulatory T cells inhibit B-cell responses and are involved in systemic lupus erythematosus. (2016) (37)
Interleukin-1 receptor-associated kinase-M suppresses systemic lupus erythematosus (2011) (37)
A novel type of secondary modification of two CCGG residues in the human γδβ-globin gene locus (1980) (37)
Proteolytic Regulation of Nuclear Factor of Activated T (NFAT) c2 Cells and NFAT Activity by Caspase-3* (2006) (36)
Activation of NOD2 in vivo induces IL‐1β production in the eye via caspase‐1 but results in ocular inflammation independently of IL‐1 signaling (2008) (36)
TGF- β suppresses the activation of CD8 + T cells when naïve but promotes their survival and function once antigen-experienced: a two-faced impact on autoimmunity (2008) (36)
The I region of the C57BL/10 mouse: characterization and physical linkage to H-2K of an SB beta-like class II pseudogene, psi A beta 3. (1985) (36)
MAP3K2-regulated intestinal stromal cells define a distinct stem cell niche (2021) (35)
Deficiency in the c-Jun NH2-terminal kinase signaling pathway confers susceptibility to hyperoxic lung injury in mice. (2003) (35)
Antigen-mediated regulation in monoclonal gammopathies and myeloma. (2018) (35)
Human CD4 restores normal T cell development and function in mice deficient in murine CD4 (1994) (35)
Contrasting geographic patterns of genetic variation for molecular markers vs. phenotypic traits in the energy grass Miscanthus sinensis (2013) (35)
Inflammatory Regulation by TLR3 in Acute Hepatitis1 (2009) (35)
Inactivation of JNK1 enhances innate IL-10 production and dampens autoimmune inflammation in the brain (2006) (35)
NOD2 Signaling Contributes to Host Defense in the Lungs against Escherichia coli Infection (2012) (35)
Isolation and characterization of a human collagen α 1(I)-like gene from a cosmid library (1982) (35)
Nature of the base sequence conserved in the mitochondrial DNA of a low-density petite. (1973) (35)
Deletion of interleukin‐6 in mice with the dominant negative form of transforming growth factor β receptor II improves colitis but exacerbates autoimmune cholangitis (2010) (34)
IL-10 Receptor Signaling Empowers Regulatory T Cells to Control Th17 Responses and Protect from GN. (2018) (34)
A guanosine to adenosine transition in the 3' terminal extracistronic region of bacteriophage Q beta RNA leading to loss of infectivity. (1977) (34)
Defective Th Function Induced by a Dominant-Negative cAMP Response Element Binding Protein Mutation Is Reversed by Bcl-21 (2000) (34)
A Protective Function of IL-22BP in Ischemia Reperfusion and Acetaminophen-Induced Liver Injury (2017) (34)
Efficacy of human Lyme disease vaccine formulations in a mouse model. (1995) (34)
BRG1‐mediated immune tolerance: facilitation of Treg activation and partial independence of chromatin remodelling (2013) (34)
Neurogenesis Epigenetic DNA Demethylation and Adult Neuronal Activity Induced Gadd 45 b Promotes (2009) (34)
Twisting the Th1/Th2 immune response via the retinoid X receptor: Lessons from a genetic approach (2005) (34)
Peripherally Induced Tolerance Depends on Peripheral Regulatory T Cells That Require Hopx To Inhibit Intrinsic IL-2 Expression (2015) (34)
A Pool of Central Memory-Like CD4 T Cells Contains Effector Memory Precursors (2003) (34)
-Terminal Kinase (JNK)1 and JNK2 Have Distinct Roles in CD8 T Cell Activation (2002) (33)
Innate immune recognition of flagellin limits systemic persistence of Brucella (2013) (33)
A transcription map for the rabbit β-globin gene (1981) (33)
PTPN22 inhibition resets defective human central B cell tolerance (2016) (33)
Antigen presentation on artificial acellular substrates: modular systems for flexible, adaptable immunotherapy (2009) (33)
Differential requirement for the stress-activated protein kinase/c-Jun NH(2)-terminal kinase in RNAdamage-induced apoptosis in primary and in immortalized fibroblasts. (2000) (33)
Lymphotoxin-alpha- and lymphotoxin-beta-deficient mice differ in susceptibility to scrapie: evidence against dendritic cell involvement in neuroinvasion. (2002) (33)
Immunoglobulin A Targets a Unique Subset of the Microbiota in Inflammatory Bowel Disease. (2020) (33)
A predicted structure for the mitochondrial genome from the fertile cytoplasm of maize (1983) (33)
Expression of activated CDC42 induces T cell apoptosis in thymus and peripheral lymph organs via different pathways (1999) (32)
Loss of toll-like receptor 3 function improves glucose tolerance and reduces liver steatosis in obese mice. (2012) (32)
A chromosomal Borrelia burgdorferi gene encodes a 22-kilodalton lipoprotein, P22, that is serologically recognized in Lyme disease (1994) (32)
Caspase regulation of genotoxin‐induced neural precursor cell death (2003) (32)
Polyethyleneimine is a potent mucosal adjuvant for glycoproteins with innate and adaptive immune activating properties (2012) (31)
Murine leukemia virus sequences are encoded in the murine major histocompatibility complex. (1984) (31)
The Role of RIP2 in p38 MAPK Activation in the Stressed Heart* (2008) (31)
Interactions between Nod-Like Receptors and Intestinal Bacteria (2013) (31)
Prominent T lymphocyte response to Borrelia burgdorferi from peripheral blood of unexposed donors (1994) (31)
Mouse mammary tumor virus in anti-mitochondrial antibody producing mouse models. (2011) (31)
Lymphotoxin-beta-deficient mice show defective antiviral immunity. (1999) (31)
IL-10 producing regulatory and helper T-cells in systemic lupus erythematosus. (2019) (31)
DUSP10 regulates intestinal epithelial cell growth and colorectal tumorigenesis (2016) (31)
MAPK Phosphatase 5 Expression Induced by Influenza and Other RNA Virus Infection Negatively Regulates IRF3 Activation and Type I Interferon Response. (2015) (31)
Analysis of microbiota alterations in inflammasome-deficient mice. (2013) (30)
B7-1 expression by a non-antigen presenting cell-derived tumor. (1995) (30)
The rabbit beta-globin gene contains a large large insert in the coding sequence. (1977) (30)
NF-kappa B binds within a region required for B-cell-specific expression of major histocompatibility complex class II gene E alpha d (1989) (30)
Sequence homology of nuclear and mitochondrial DNAs of different yeasts. (1975) (30)
Deprivation of MKK7 in cardiomyocytes provokes heart failure in mice when exposed to pressure overload. (2011) (30)
Role of TLR3 in the immunogenicity of replicon plasmid-based vaccines (2008) (30)
Innate recognition of non-self nucleic acids (2008) (30)
IL-10 Mediated Regulation of Liver Inflammation during Acute Murine Cytomegalovirus Infection (2012) (30)
Costimulation in tolerance and autoimmunity. (1995) (30)
IL‐1 receptor‐associated kinase M downregulates DSS‐induced colitis† (2010) (30)
Nlrp 9 b inflammasome restricts rotavirus infection in intestinal epithelial cells (2018) (30)
Death by numbers (2000) (30)
Configuration-dependent Presentation of Multivalent IL-15:IL-15Rα Enhances the Antigen-specific T Cell Response and Anti-tumor Immunity* (2015) (30)
Evidence for a pathogenic role of extrafollicular, IL-10–producing CCR6+B helper T cells in systemic lupus erythematosus (2020) (29)
NOD2 Regulates CXCR3-Dependent CD8+ T Cell Accumulation in Intestinal Tissues with Acute Injury (2014) (29)
Hypersensitive site 6 of the Th2 locus control region is essential for Th2 cytokine expression (2013) (29)
DNA synthesis by isolated mitochondria. 3. Characterization of D-loop DNA, a novel intermediate in mtDNA synthesis. (1971) (29)
Regulation of Immune Response and Inflammatory Reactions against Viral Infection by VCAM-1 (2008) (29)
The E3 ligase Itch and deubiquitinase Cyld act together to regulate Tak1 and inflammation (P2107) (2013) (29)
Mice Deficient in Interleukin-1β Converting Enzyme (1998) (29)
Up-regulation of Hlx in immature Th cells induces IFN-gamma expression. (2004) (29)
Producing GM-CSF: a unique T helper subset? (2014) (29)
Inducible costimulator is essential for collagen-induced arthritis. (2003) (29)
Tumor necrosis factor-alpha and the progression of diabetes in non-obese diabetic mice. (1999) (29)
Molar tooth development in caspase-3 deficient mice. (2006) (29)
Interleukin 1 receptor-associated kinase m impairs host defense during pneumococcal pneumonia. (2012) (29)
Comparison of whole-cell antibodies and an antigenic flagellar epitope of Borrelia burgdorferi in serologic tests for diagnosis of Lyme borreliosis (1992) (28)
Revised nomenclature of mouse H-2 genes. (1990) (28)
Maturation modulates caspase‐1‐independent responses of dendritic cells to Anthrax Lethal Toxin (2008) (28)
Inflammasome Activation by Campylobacter jejuni (2014) (28)
Receptor-Interacting Protein 2 Controls Pulmonary Host Defense to Escherichia coli Infection via the Regulation of Interleukin-17A (2011) (27)
Inflammasome activation and metabolic disease progression. (2014) (27)
Molecular characterization of the humoral response to the 41-kilodalton flagellar antigen of Borrelia burgdorferi, the Lyme disease agent (1991) (27)
IL-27 signalling promotes adipocyte thermogenesis and energy expenditure (2021) (27)
CD4+ICOS+ T lymphocytes inhibit T cell activation 'in vitro' and attenuate autoimmune encephalitis 'in vivo'. (2008) (27)
The missing link: how the inflammasome senses oxidative stress (2010) (26)
Allospecific cytolytic T lymphocytes recognize conformational determinants on hybrid mouse transplantation antigens (1985) (26)
Plasticity of Th17 Cells in Autoimmune Kidney Diseases (2016) (26)
Excitatory transmission onto AgRP neurons is regulated by cJun NH2-terminal kinase 3 in response to metabolic stress (2016) (26)
TGF-beta signaling is required for the function of insulin-reactive T regulatory cells. (2006) (26)
Interleukin-1 Receptor-Associated Kinase M-Deficient Mice Demonstrate an Improved Host Defense during Gram-negative Pneumonia (2012) (26)
Sequence requirements for the transcription of the rabbit beta-globin gene in vivo: the -80 region. (1982) (26)
Thymus-leukemia antigen interacts with T cells and self-peptides. (1996) (26)
Site-directed mutagenesis: effect of an extracistronic mutation on the in vitro propagation of bacteriophage Qbeta RNA. (1975) (26)
Defective p53 engagement after the induction of DNA damage in cells deficient in topoisomerase 3β (2008) (26)
IL-12/23p40-dependent clearance of Anaplasma phagocytophilum in the murine model of human anaplasmosis. (2007) (25)
Human CD4-major histocompatibility complex class II (DQw6) transgenic mice in an endogenous CD4/CD8-deficient background: reconstitution of phenotype and human-restricted function (1994) (25)
Autoimmunity without diabetes in transgenic mice expressing beta cell-specific CD86, but not CD80: parameters that trigger progression to diabetes. (1998) (24)
Effector CD4+ T Cell Expression Signatures and Immune-Mediated Disease Associated Genes (2012) (24)
Spatial proximity of homologous alleles and long noncoding RNAs regulate a switch in allelic gene expression (2015) (24)
Tissue immunogenicity: the role of MHC antigen and the lymphocyte costimulator B7-1. (1996) (24)
CD28 and ICOS play complementary non-overlapping roles in the development of Th2 immunity in vivo. (2009) (24)
Distinct Effects of Jak3 Signaling on αβ and γδ Thymocyte Development (1999) (24)
Myosin VI regulates gene pairing and transcriptional pause release in T cells (2015) (24)
Differential expression of transcription directed by a discrete NF-AT binding element from the IL-4 promoter in naive and effector CD4 T cells. (1997) (24)
Costimulatory strength influences the differential effects of transforming growth factor beta1 for the generation of CD8+ regulatory T cells. (2008) (24)
Characterization of the Role of Major Histocompatibility Complex in Type 1 Diabetes Recurrence after Islet Transplantation (2004) (23)
CD45 ligation expands Tregs by promoting interactions with DCs. (2014) (23)
DNA sequences required for regulated expression of beta-globin genes in murine erythroleukaemia cells. (1984) (23)
JNK2 negatively regulates CD8+ T cell effector function and anti‐tumor immune response (2007) (23)
Characterization of a 30-kDa Borrelia burgdorferi substrate-binding protein homologue. (1996) (23)
How to Define Biomarkers of Human T Cell Aging and Immunocompetence? (2013) (23)
Selection of variant Borrelia burgdorferi isolates from mice immunized with outer surface protein A or B (1995) (23)
Development of autoreactive diabetogenic T cells in the thymus of NOD mice. (2005) (23)
Requirement of Voltage-Gated Calcium Channel ß4 Subunit for T Lymphocyte Functions (2005) (23)
Treatment of granuloma annulare and suppression of proinflammatory cytokine activity with tofacitinib. (2020) (23)
Role of IRAK-M in Alcohol Induced Liver Injury (2013) (23)
Reactivation of a major histocompatibility complex class II gene in mouse plasmacytoma cells and mouse T cells (1992) (23)
BID-D59A is a potent inducer of apoptosis in primary embryonic fibroblasts. (2013) (22)
A 55-kilodalton antigen encoded by a gene on a Borrelia burgdorferi 49-kilobase plasmid is recognized by antibodies in sera from patients with Lyme disease (1995) (22)
Adaptive and Innate Transforming Growth Factor β Signaling Impact Herpes Simplex Virus 1 Latency and Reactivation (2011) (22)
A Protein Scaffold Coordinates SRC-Mediated JNK Activation in Response to Metabolic Stress. (2017) (22)
Genetic engineering: Prospects for transforming monocot crop plants (1984) (22)
The use of the polymerase chain reaction to map CD4+ T cell epitopes (1991) (22)
Receptor interacting protein-2 contributes to host defense against Anaplasma phagocytophilum infection. (2012) (22)
Role of L-selectin in the development of autoimmune diabetes in non-obese diabetic mice. (2004) (22)
Novel antagonist antibody to TLR3 blocks poly(I:C)-induced inflammation in vivo and in vitro. (2011) (21)
Activation of CD4 T cells by Raf-independent effectors of Ras (2003) (21)
Genetic complexity of mitochondrial DNA from Euglena gracilis. (1974) (21)
Transforming Growth Factor-b Controls Development, Homeostasis, and Tolerance of T Cells by Regulatory T Cell-Dependent and -Independent Mechanisms (21)
Selective expression of class II E alpha d gene in transgenic mice. (1989) (21)
Mutant cell lines unresponsive to alpha/beta and gamma interferon are defective in tyrosine phosphorylation of ISGF-3 alpha components (1994) (21)
Praziquantel Facilitates IFN-γ-Producing CD8+ T Cells (Tc1) and IL-17-Producing CD8+ T Cells (Tc17) Responses to DNA Vaccination in Mice (2011) (21)
Requirement of JIP1-Mediated c-Jun N-Terminal Kinase Activation for Obesity-Induced Insulin Resistance (2010) (21)
T cells from epicutaneously immunized mice are prone to T cell receptor revision. (2005) (21)
Transgenic mice expressing constitutive levels of IL-2 in islet beta cells develop diabetes. (1994) (21)
IL-10 signaling in CD4+ T cells is critical for the pathogenesis of collagen-induced arthritis (2011) (21)
Skin inflammation driven by differentiation of quiescent tissue-resident ILCs into a spectrum of pathogenic effectors (2018) (21)
T-Cell Activation: Two for T (1995) (21)
Signal Transduction Cross Talk Mediated by Jun N-Terminal Kinase-Interacting Protein and Insulin Receptor Substrate Scaffold Protein Complexes (2009) (20)
A Molecular Chipper technology for CRISPR sgRNA library generation and functional mapping of noncoding regions (2016) (20)
Kinetic complexity of Tetrahymena pyriformis nuclear deoxyribonucleic acid. (1970) (20)
Antimycin A induced cardioprotection is dependent on pre-ischemic p38-MAPK activation but independent of MKK3. (2005) (20)
Structure and expression of the human globin genes and murine histocompatibility antigen genes. (1983) (20)
The hook protein of Borrelia burgdorferi, encoded by the flgE gene, is serologically recognized in Lyme disease (1995) (20)
Recognition of interspecies hybrid class I histocompatibility antigens by antigen-specific cytolytic T lymphocytes. (1985) (20)
Caspases and T lymphocytes: a flip of the coin? (2003) (20)
Breeding Strategies to Improve Miscanthus as a Sustainable Source of Biomass for Bioenergy and Biorenewable Products (2019) (19)
Tissue-specific expression of alpha-amylase. (1981) (19)
NK cell receptor NKG2D enforces proinflammatory features and pathogenicity of Th1 and Th17 cells (2020) (19)
Overcoming the hurdles in using mouse genetic models that block TGF-beta signaling. (2010) (19)
IL22BP Mediates the Antitumor Effects of Lymphotoxin Against Colorectal Tumors in Mice and Humans (2020) (19)
Lack of Sprouty 1 and 2 enhances survival of effector CD8+ T cells and yields more protective memory cells (2018) (19)
Thymic development in human CD4 transgenic mice. Positive selection occurs after commitment to the CD8 lineage. (1994) (19)
CD8 Locus Nuclear Dynamics during Thymocyte Development (2010) (19)
Editing the Mouse Genome Using the CRISPR-Cas9 System. (2016) (19)
The induction and function of the anti-inflammatory fate of TH17 cells (2020) (19)
Treatment of allergic inflammation and hyperresponsiveness by a simple compound, Bavachinin, isolated from Chinese herbs (2013) (19)
A pathway involving HDAC5, cFLIP and caspases regulates expression of the splicing regulator polypyrimidine tract binding protein in the heart (2013) (19)
Dendritic Cell Differentiation Induced by a Self-Peptide Derived from Apolipoprotein E1 (2008) (19)
T cells are responsive to the simian virus 40 large tumor antigen transgenically expressed in pancreatic islets. (1993) (18)
Activation of nucleotide oligomerization domain 2 exacerbates a murine model of proteoglycan‐induced arthritis (2009) (18)
Protective Function of Mitogen‐Activated Protein Kinase Phosphatase 5 in Aging‐ and Diet‐Induced Hepatic Steatosis and Steatohepatitis (2019) (18)
TLR Signaling Prevents Hyperoxia-Induced Lung Injury by Protecting the Alveolar Epithelium from Oxidant-Mediated Death (2012) (18)
CD86 Has Sustained Costimulatory Effects on CD8 T Cells1 (2007) (18)
A crucial role of CD4 T cells as a functional source of CD154 in the initiation of insulin-dependent diabetes mellitus in the non-obese diabetic mouse. (2003) (18)
An IL-9–pulmonary macrophage axis defines the allergic lung inflammatory environment (2022) (18)
IL‐4 induces a suppressive IL‐10‐producing CD8+ T cell population via a Cdkn2a‐dependent mechanism (2013) (18)
Paramecium mitochondrial DNA. Renaturation and hybridisation studies. (1971) (18)
Legionella pneumophila Strain 130b Evades Macrophage Cell Death Independent of the Effector SidF in the Absence of Flagellin (2017) (18)
Qa-2 antigen encoded by Q7b is biochemically indistinguishable from Qa-2 expressed on the surface of C57BL/10 mouse spleen cells. (1988) (18)
Sulfamethoxazole drug stress upregulates antioxidant immunomodulatory metabolites in Escherichia coli (2020) (18)
Beneficial innate signaling interference for antibacterial responses by a Toll-like receptor–mediated enhancement of the MKP-IRF3 axis (2013) (18)
PTPN22 inhibition resets defective human central B cell tolerance. (2016) (18)
Differential requirements for NF-kappaB and AP-1 trans-activation in response to minimal TCR engagement by a partial agonist in naive CD8 T cells. (1999) (17)
Long-term consumption of caffeine-free high sucrose cola beverages aggravates the pathogenesis of EAE in mice (2017) (17)
Pharmacological postconditioning effect of muramyl dipeptide is mediated through RIP2 and TAK1. (2009) (17)
T cell unresponsiveness correlates with quantitative TCR levels in a transgenic model. (1993) (17)
TGF-beta signaling regulates CD8+ T cell responses to high- and low-affinity TCR interactions. (2005) (17)
Homeobox protein Hhex negatively regulates Treg cells by inhibiting Foxp3 expression and function (2019) (17)
Managing Associations Between Different Chromosomes (2006) (17)
Impaired Basophil Induction Leads to an Age-Dependent Innate Defect in Type 2 Immunity during Helminth Infection in Mice (2011) (17)
Induction of experimental autoimmune encephalomyelitis in the absence of c-Jun N-terminal kinase 2. (2002) (17)
NLRP6 inflammasome is a regulator of colonic microbial ecology and risk for colitis (2013) (17)
Disruption of cytokine signaling in lymphoid development: unique contributions of the common cytokine gamma chain and the Jak3 kinase. (1996) (17)
Developing Miscanthus for Bioenergy (2011) (17)
Macrophage IL-12p70 signaling prevents HSV-1-induced CNS autoimmunity triggered by autoaggressive CD4+ Tregs. (2011) (17)
Regulation of Adipose Tissue Inflammation and Insulin Resistance by MAPK Phosphatase 5* (2015) (17)
c-Jun NH2-Terminal Kinase 2 Inhibits Gamma Interferon Production during Anaplasma phagocytophilum Infection (2007) (17)
m6A mRNA methylation-directed myeloid cell activation controls progression of NAFLD and obesity (2021) (17)
TLR8 Couples SOCS-1 and Restrains TLR7-Mediated Antiviral Immunity, Exacerbating West Nile Virus Infection in Mice (2016) (17)
Modulating HIV-1 envelope glycoprotein conformation to decrease the HIV-1 reservoir. (2021) (16)
NLRP6 and Dysbiosis: Avoiding the Luring Attraction of Over-Simplification. (2018) (16)
Overexpression of IL-7R alpha provides a competitive advantage during early T-cell development. (2004) (16)
Accelerated diabetes in rat insulin promoter-tumor necrosis factor-alpha transgenic nonobese diabetic mice lacking major histocompatibility class II molecules. (2003) (16)
MKK3 signalling plays an essential role in leukocyte-mediated pancreatic injury in the multiple low-dose streptozotocin model (2008) (16)
Expression of interleukin-6 by airway epithelial cells. Effects on airway inflammation and hyperreactivity in transgenic mice. (1995) (16)
gamma-beta-Thalassaemia studies showing that deletion of the gamma- and delta-genes influences beta-globin gene expression in man. (1980) (16)
Essential roles for Cavβ2 and Cav1 channels in thymocyte development and T cell homeostasis (2015) (16)
Amino acid polymorphisms altering the glycosylation of IL-2 do not protect from type 1 diabetes in the NOD mouse (2009) (16)
Microbiota Keep the Intestinal Clock Ticking (2013) (16)
Identification of a Borrelia burgdorferi OspA T cell epitope that promotes anti-OspA IgG in mice. (1996) (16)
NF-kappa B-inducing kinase regulates selected gene expression in the Nod2 signaling pathway. (2006) (16)
Effect of Bavachinin and its derivatives on T cell differentiation. (2014) (16)
Autoinflammatory syndromes and infections: pathogenetic and clinical implications. (2008) (16)
Walking through the forest of transgenic models of human disease (1999) (15)
LoxP-FRT Trap (LOFT): a simple and flexible system for conventional and reversible gene targeting (2012) (15)
MyD 88 signalling in colonic mononuclear phagocytes drives colitis in IL-10-deficient mice (2012) (15)
Pyrimidine tract analysis of mtDNA from a "low-density" petite mutant of yeast. (1972) (15)
The molecular basis of T cell differentiation. (1999) (15)
Role of OCT-1 and partner proteins in T cell differentiation. (2016) (15)
DNA-DNA hybridization on nitrocellulose filters. 2. Concatenation effects. (1974) (15)
Lyme borreliosis in transgenic mice tolerant to Borrelia burgdorferi OspA or B. (1995) (15)
T cell sensitivity to TGF-β is required for the effector function but not the generation of splenic CD8+ regulatory T cells induced via the injection of antigen into the anterior chamber (2009) (15)
Roles of mTORC1 and mTORC2 in controlling γδ T1 and γδ T17 differentiation and function (2020) (15)
In vivo diabetogenic action of CD4+ T lymphocytes requires Fas expression and is independent of IL‐1 and IL‐18 (2011) (14)
DNA from isolated pellicles of Tetrahymena. (1971) (14)
Size and configuration of Tetrahymena mitochondrial deoxyribonucleic acid. (1970) (14)
Analysis of the beta-delta-globin gene loci in normal and Hb Lepore DNA: direct determination of gene linkage and intergene distance. (1978) (14)
Preferential Presence of Decorin-Binding Protein B (BBA25) and BBA50 Antibodies in Cerebrospinal Fluid of Patients with Neurologic Lyme Disease (2004) (14)
T Cell Receptor Mediated Calcium Entry Requires Alternatively Spliced Cav1.1 Channels (2016) (14)
PolyI:C-induced reduction in uptake of soluble antigen is independent of dendritic cell activation. (2009) (14)
Enteric Nervous System-Derived IL-18 Orchestrates Mucosal Barrier Immunity (2020) (14)
Signaling and cell death in lymphocytes (2007) (14)
New insights into insulin dependent diabetes mellitus from studies with transgenic mouse models. (1997) (14)
Nonfunctional thyroglobulin messenger RNA in goats with hereditary congenital goiter. (1981) (14)
TNF‐α impairs peripheral tolerance towards β‐cells, and local costimulation by B7.1 enhances the effector function of diabetogenic T cells (2003) (14)
Epigenetic regulation of Ifng expression (2007) (13)
CD116+ fetal precursors migrate to the perinatal lung and give rise to human alveolar macrophages (2022) (13)
p 38 MAPK Autophosphorylation Drives Macrophage IL-12 Production during Intracellular Infection 1 (2005) (13)
Post-infarction remodeling is independent of mitogen-activated protein kinase kinase 3 (MKK3). (2007) (13)
IL-4-BATF signaling directly modulates IL-9 producing mucosal mast cell (MMC9) function in experimental food allergy. (2020) (13)
The lack of NF-κB transactivation and PKCε expression in CD4+CD8+ thymocytes correlates with negative selection (2000) (13)
Constitutively CD40–Activated B Cells Regulate CD8 T Cell Inflammatory Response by IL-10 Induction (2013) (13)
Allergic airway recall responses require IL-9 from resident memory CD4+ T cells (2022) (13)
Structure of the murine immune response I-A beta locus: sequence of the I-A beta gene and an adjacent beta-chain second domain exon. (1983) (13)
Reprogramming transcription during the differentiation of precursor CD4+ T cells into effector Th1 and Th2 cells. (1999) (13)
m6A mRNA modification maintains colonic epithelial cell homeostasis via NF-κB–mediated antiapoptotic pathway (2022) (13)
Presynaptic Kv3 channels are required for fast and slow endocytosis of synaptic vesicles (2021) (13)
Virally induced inflammation triggers fratricide of Fas-ligand-expressing beta-cells. (2004) (13)
Role of IL-10 Receptor Signaling in the Function of CD4+ T-Regulatory Type 1 cells: T-Cell Therapy in Patients with Inflammatory Bowel Disease. (2018) (13)
TGF-β, T-cell tolerance and immunotherapy of autoimmune diseases and cancer (2006) (13)
The detection and use of hemoglobin mutants in the direct analysis of human globin genes. (1980) (13)
Disulfide Isomerization After Membrane Release of Its SAR Domain Activates P 1 Lysozyme (2005) (13)
The transcription of eukaryotic genes (1980) (13)
p21 Ras/Impedes Mitogenic Signal Propagation Regulates Cytokine Production and Migration in CD4 T Cells* (2008) (13)
An ospA frame shift, identified from DNA in Lyme arthritis synovial fluid, results in an outer surface protein A that does not bind protective antibodies. (1995) (13)
[Multiple D-loops in Tetrahymena mitochondrial DNA]. (1972) (13)
Site-directed mutagenesis: generation of an extracistronic mutation in bacteriophage Q beta RNA. (1974) (12)
Protective immunity in lyme borreliosis. (1993) (12)
Development of Autoimmune Diabetes in the Absence of Detectable IL-17A in a CD8-Driven Virally Induced Model (2011) (12)
A humanized mouse model of chronic COVID-19 to evaluate disease mechanisms and treatment options (2021) (12)
Combined liver–cytokine humanization comes to the rescue of circulating human red blood cells (2021) (12)
Colitis Promotes a Pathological Condition of the Liver in the Absence of Foxp3+ Regulatory T Cells (2018) (12)
Targeted expression of the anti-apoptotic gene CrmA to NOD pancreatic islets protects from autoimmune diabetes. (2006) (12)
Immunological tolerance to a pancreatic antigen as a result of local expression of TNFalpha by islet beta cells. (1997) (12)
Polymorphisms of human γ-globin genes in Mediterranean populations (1979) (12)
Detecting “different”: Pyrin senses modified GTPases (2014) (11)
DNA synthesis by isolated mitochondria. IV. Isolation of an intermediate containing newly synthesized DNA in full-length light strands. (1972) (11)
Antigen Presentation in MHC Class II Transgenic Mice: Stimulation versus Tolerization (1990) (11)
Immunology: Sensing the enemy within (2007) (11)
CD4 T cell-intrinsic STING signaling controls the differentiation and effector functions of TH1 and TH9 cells (2022) (11)
The regulation of CD4 T cell differentiation. (1998) (11)
Differential outcome of infection with attenuated Salmonella in MyD88-deficient mice is dependent on the route of administration. (2013) (11)
Enhanced engraftment of human myelofibrosis stem and progenitor cells in MISTRG mice. (2020) (11)
Epigenetic and transcriptional programs lead to default IFN-γ production by γδ T cells (2007) (11)
Autoimmunity. What is the turning point? (1999) (11)
Isolation and characterization of the oligo(dA-dT) clusters and their flanking DNA segments in the rabbit genome. (1977) (11)
Molecular biology. Managing associations between different chromosomes. (2006) (11)
Required Roles of Bax and JNKs in Central and Peripheral Nervous System Death of Retinoblastoma-deficient Mice* (2008) (11)
Inhibition of type 1 immunity with tofacitinib is associated with marked improvement in longstanding sarcoidosis (2022) (11)
DNA-DNA hybridization on nitrocellulose filters. 1. General considerations and non-ideal kinetics. (1974) (11)
IL-10 from CD 4 + CD 25 2 Foxp 3 2 CD 127 2 Adaptive Regulatory T Cells Modulates Parasite Clearance and Pathology during Malaria Infection (2008) (11)
The RNA helicase Dhx15 mediates Wnt-induced antimicrobial protein expression in Paneth cells (2021) (11)
c-Cbl deficiency leads to diminished lymphocyte development and functions in an age-dependent manner (2010) (11)
A Novel Molecule Designed to Keep Bacteria out of the Urinary Tract: A Toll-Like Receptor that Prevents Infection by Uropathogenic Bacteria. Science 303: 1522–1526, 2004 (2004) (11)
Localization of repetitive and unique DNA sequences neighbouring the rabbit beta-globin gene. (1980) (10)
Bacterial Autoimmune Drug Metabolism Transforms an Immunomodulator into Structurally and Functionally Divergent Antibiotics. (2020) (10)
Pillars Article: The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells. Cell. 1997. 89: 587-596. (2016) (10)
The tiny conductor: immune regulation via commensal organisms. (2008) (10)
Erratum: Borrelia burgdorferi P35 and P37 proteins, expressed in vivo, elicit protective immunity (Immunity 6 (531-539)) (1998) (10)
Homeodomain only protein is required for the function of induced regulatory T cells in dendritic cell-mediated peripheral T cell unresponsiveness (2010) (10)
Transcriptional control in the Th1/Th2 decision T-cell subsets: (1997) (10)
Does CD40 Ligation Induce B Cell Negative Selection?1 (2002) (10)
miR-181a Modulation of ERK-MAPK Signaling Sustains DC-SIGN Expression and Limits Activation of Monocyte-Derived Dendritic Cells. (2020) (10)
TLR 3 Deletion Limits Mortality and Disease Severity due to Phlebovirus Infection 1 (2006) (9)
BID-D59A is a potent inducer of apoptosis in primary embryonic fibroblasts. (2012) (9)
Glycosylphosphatidylinositol‐anchored H‐2Db molecules are defective in antigen processing and presentation to cytotoxic T lymphocytes (1996) (9)
T H 2, allergy and group 2 innate lymphoid (2013) (9)
m6A modifications regulate intestinal immunity and rotavirus infection (2021) (9)
MHC class II expression through a hitherto unknown pathway supports T helper cell-dependent immune responses: implications for MHC class II deficiency. (2006) (9)
No Oxygen? No Glucose? No Problem: Fatty Acid Catabolism Enhances Effector CD8+ TILs. (2017) (9)
Consequences of intrathymic TCR engagement by partial agonist on selection events and peripheral T cell activation program. (1998) (9)
hnRNPA2B1: a nuclear DNA sensor in antiviral immunity (2019) (9)
Interleukin-10 improves stroke outcome by controlling the detrimental Interleukin-17A response (2021) (9)
The presence of (dA.dT)20-25 tracts in the DNA of primitive eukaryotes. (1976) (9)
Expression of epidermal-growth-factor receptor in the K562 cell line by transfection. Altered receptor biochemistry. (1990) (9)
Serologic analysis of dogs, horses, and cottontail rabbits for antibodies to an antigenic flagellar epitope of Borrelia burgdorferi (1993) (9)
Inflammasome-mediated dysbiosis regulatesprogressionofNAFLDandobesity (2012) (9)
Human neutrophil development and functionality are enabled in a humanized mouse model (2022) (8)
Metabolic Stress Boosts Humoral Responses In Vivo Independently of Inflammasome and Inflammatory Reaction (2011) (8)
JNK1 signaling in the proximal tubule causes cell death and acute renal failure in rat and mouse models of renal ischaemia/reperfusion injury. (2021) (8)
Mex3B: a coreceptor to present dsRNA to TLR3 (2016) (8)
Enhanced Anti-Serpin Antibody Activity Inhibits Autoimmune Inflammation in Type 1 Diabetes (2012) (8)
Placenta-Specific Expression of the Rat Growth Hormone-Releasing Hormone Gene Promoter in Transgenic Mice. (1997) (8)
Enoxacin Up‐Regulates MicroRNA Biogenesis and Down‐Regulates Cytotoxic CD8 T‐Cell Function in Autoimmune Cholangitis (2021) (8)
CD8αα and T Cell Memory (2004) (8)
Modulating Vaccine Responses with Innate Immunity (2016) (8)
173 Interleukin-22 Provides Protection to Tissues during Inflammation (2007) (8)
Helper T cell differentiation: a role for SAP? (2001) (8)
DNA sequences necessary for transcription of the rabbit beta-globin gene in vivo. (1982) (8)
IL-17 Receptor C Signaling Controls CD4+ TH17 Immune Responses and Tissue Injury in Immune-Mediated Kidney Diseases (2021) (8)
The isolation of duplex DNA containing (dA·dT) clusters by affinity chromatography on poly(U) sephadex (1975) (8)
Mouse pulmonary interstitial macrophages mediate the pro-tumorigenic effects of IL-9 (2022) (7)
Linkage mapping evidence for a syntenic QTL associated with flowering time in perennial C4 rhizomatous grasses Miscanthus and switchgrass (2020) (7)
128 : Truncated form of transforming growth factor-β receptor II, but not its absence, induces memory CD8+ T cell expansion and lymphoproliferative disorder in mice (2013) (7)
tRNA-m1A modification promotes T cell expansion via efficient MYC protein synthesis (2022) (7)
The lack of NF-kappa B transactivation and PKC epsilon expression in CD4(+)CD8(+) thymocytes correlates with negative selection. (2000) (7)
Macrophage scavenger receptor 1 controls Chikungunya virus infection through autophagy in mice (2020) (7)
Distinct effects of Jak3 signaling on alphabeta and gammadelta thymocyte development. (1999) (7)
REACTIVITY OF WHITE-FOOTED MOUSE AND RACCOON SERA TO WHOLE CELL AND RECOMBINANT ANTIGENS OF BORRELIA BURGDORFERI (1995) (7)
Inflammatory Regulation by TLR3 in Acute Hepatitis (2009) (7)
Regulation of the activity of the transcription factors AP-1 and NFAT during differentiation of precursor CD4+ T-cells into effector cells. (1997) (7)
The hematopoiesis paradigm: clarity or ambiguity? (2008) (7)
Autoimmunity. How to know thy self. (1996) (7)
Isolation of beta-globin-related genes from a human cosmid library. (1981) (7)
c-Jun NH 2 -Terminal Kinase Is Essential for the Regulation of AP-1 by Tumor Necrosis Factor (2003) (7)
The contribution of insulitis to diabetes development in tumor necrosis factor transgenic mice. (1996) (7)
Family‐based study reveals decreased abundance of sputum Granulicatella in asthmatics (2018) (7)
Viral replication in human macrophages enhances an inflammatory cascade and interferon driven chronic COVID-19 in humanized mice. (2021) (7)
Interspecies commensal interactions have nonlinear impacts on host immunity. (2022) (7)
Sugar-Coated Regulation of T Cells (2005) (7)
Detecting regions of differential abundance between scRNA-seq datasets (2019) (7)
Interferon-γ expression by Th 1 effector T cells mediated by the p 38 MAP kinase signaling pathway (2013) (7)
6 – SITE-DIRECTED MUTAGENESIS AS A TOOL IN GENETICS (1978) (7)
Toll-like receptors 1 and 2 heterodimers alter Borrelia burgdorferi gene expression in mice and ticks. (2009) (7)
Intracellular debugging (2003) (7)
Tissue-specific, inducible andfunctional expression oftheEad MHC class II geneintransgenic mice (1985) (6)
A novel type of secondary modification of two CCGG residues in the human gamma delta beta-globin gene locus. (1980) (6)
BID-D59A Is a Potent Inducer of Apoptosis in Primary Embryonic Fibroblasts* (2003) (6)
Corrigendum: TH2, allergy and group 2 innate lymphoid cells (2013) (6)
Transcriptional profiling of macrophages in situ in metastatic melanoma reveals localization-dependent phenotypes and function (2021) (6)
Tissue-specific expression of α-amylase (1981) (6)
Revised nomenclature of mouseH-2 genes (2005) (6)
Detection of differentially abundant cell subpopulations discriminates biological states in scRNA-seq data (2019) (6)
Cerebellar Kv3.3 potassium channels activate TANK-binding kinase 1 to regulate trafficking of the cell survival protein Hax-1 (2021) (6)
Immunology: Cascade into clarity (2008) (6)
Physical mapping of repetitive DNA sequences neighboring the rabbit beta-globin gene. (1978) (6)
Placenta-specific expression of the rat growth hormone-releasing hormone gene promoter in transgenic mice. (1997) (6)
I-E transgenic mice: A model system to dissect the regulation and function of MHC class II genes in vivo (1990) (6)
RNA m6A demethylase ALKBH5 regulates the development of γδ T cells (2020) (6)
The Intestine: where amazing things happen (2011) (6)
DNA synthesis by isolated mitochondria. V. Electron microscopy of replicative intermediates. (1973) (6)
Evidence for the requirement for CD40—CD154 interactions in resistance to infections with attenuated Salmonella (2005) (6)
Corrigendum: Development and function of human innate immune cells in a humanized mouse model (2017) (6)
Transgenic modeling of cytokines in the investigation of pulmonary disease. (1996) (6)
Author Correction: Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity (2019) (5)
GSK3β mediates the spatiotemporal dynamics of NLRP3 inflammasome activation (2022) (5)
Inhibition of NF- k B Activity and Enhancement of Apoptosis by the Neuropeptide Calcitonin Gene-related Peptide* (2000) (5)
Cell-surface expression of H-2Db requires N-linked glycans (2004) (5)
The role of RIP2 in p38 MAPK activation in the stressed heart (2008) (5)
Corrigendum: NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells (2015) (5)
Probing the mechanism of TNF-α(cachectin)- and TNF-β(lymphotoxin)-induced pancreatic inflammation with transgenic mice* (1993) (5)
TGFbeta-mediated immunoregulation. (2006) (5)
HER2 joins AKT to inhibit STING immunity (2019) (5)
A new determinant, Qa-m208, detected on T lymphocytes and transfected L cells by a Kb-specific monoclonal antibody (2004) (5)
CD4 T cell- intrinsic STING signaling controls the differentiation and effector functions of T H 1 and T H 9 cells (2022) (5)
CD4+ T-cell-derived IL-10 promotes CNS inflammation in mice by sustaining effector T cell survival. (2022) (5)
Genomics, genetics, and genes of the immune system. (2001) (5)
Deletion of IL-12p35 induces liver fibrosis in dominant negative transforming growth factor β receptor type II mice (5)
LACC1 bridges NOS2 and polyamine metabolism in inflammatory macrophages (2022) (4)
Infl ammasome recognition of infl uenza virus is essential for adaptive immune responses (2009) (4)
Regulation of transgenic class II major histocompatibility genes in murine Langerhans cells. (1995) (4)
Erratum: Inducible costimulator is essential for collagen-induced arthritis (Journal of Clinical Investigation (2003) 111 (701-706)) (2003) (4)
Development of Humanized Mouse Models for Studying Human NK Cells in Health and Disease. (2022) (4)
Studies on MAP Kinase signaling in the immune system. (2010) (4)
IL18 signaling causes islet β cell development and insulin secretion via different receptors on acinar and β cells. (2022) (4)
Reply to: Rectally shed SARS-CoV-2 lacks infectivity: time to rethink faecal–oral transmission? (2021) (4)
Clonal anergy of I-E-tolerant T cells in transgenic mice with pancreatic expression of MHC class II I-E. (1989) (4)
Further molecular and functional evidence for the expression of H-2 allodeterminants on the AKR leukemia, K36. (1983) (4)
CD154-CD40-independent up-regulation of B7-2 on splenic antigen-presenting cells and efficient T cell priming by staphylococcal enterotoxin A. (2003) (4)
TNF-alpha impairs peripheral tolerance towards beta-cells, and local costimulation by B7.1 enhances the effector function of diabetogenic T cells. (2003) (4)
Tolerance to class II MHC in transgenic mice. (1989) (4)
The structure and expression of normal and abnormal globin genes (1979) (4)
THE STRUCTURE AND EXPRESSION OF GLOBIN GENES IN RABBIT AND MAN (1979) (4)
Chapter 15:Developing Miscanthus for Bioenergy (2010) (4)
ESCaping rejection: A step forward for embryonic-stem-cell-based regenerative medicine. (2014) (4)
Immunology at Yale (1999) (4)
The absence of an integrated copy of mitochondrial DNA in the nuclear genome of Tetrahymena pyriformis. (1973) (4)
Microbiome: Ecology of eczema (2016) (4)
Resemble and Inhibit: when RLR meets TGF-β. (2014) (4)
Antigenic characterization of products of cloned H-2b genes. (1983) (4)
Molecular cloning and analysis of H-2 class I genes of H-2b haplotype mice. (1983) (3)
Cycloheximide, an inhibitor of protein synthesis, prevents γ-interferon-induced expression of class II mRNA in a macrophage cell line (2004) (3)
ΜΙSΤRG Mice Support Good-Risk AML Engraftment (2014) (3)
The structure and expression of the haemoglobin genes. (1982) (3)
The lock-washer: a reconciliation of the RIG-I activation models (2014) (3)
Blocking TGF-b – Smad 2 / 3 innate immune signaling mitigates Alzheimer ’ s-like pathology (2008) (3)
Probing the mechanism of TNF-alpha(cachectin)- and TNF-beta(lymphotoxin)-induced pancreatic inflammation with transgenic mice. (1993) (3)
Checks and balances: IL-23 in the intestine. (2010) (3)
Evolution and expression of the transplantation antigen gene family. (1985) (3)
Regulatory T cells that become autoaggressive (2009) (3)
A self-augmenting gene expression cassette for enhanced and sustained transgene expression in the presence of proinflammatory cytokines. (2006) (3)
Despite high levels of expression in thymic epithelial cells, miR-181a1 and miR-181b1 are not required for thymic development (2018) (3)
TGF-Beta and Regulatory T Cells (2008) (3)
Immunology. CD8alphaalpha and T cell memory. (2004) (3)
Post-infarction remodeling is independent of mitogen-activated protein kinase kinase 3 (MKK3) (2007) (3)
Mitogen-activated protein kinase phosphatase-1 (MKP-1): a critical regulator of innate immune responses (2007) (3)
T cell-derived interleukin-22 drives the expression of CD155 by cancer cells to suppress NK cell function and promote metastasis (2023) (3)
PTPN 22 inhibition resets defective human central B cell tolerance (2016) (3)
Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity (2019) (3)
Vibrational Optical Coherence Tomography Detects Unique Skin Fibrotic States: Preliminary Results of Animal and Human Studies. (2020) (3)
PARP Inhibitors Are Effective in IDH1/2 Mutant MDS and AML Resistant to Targeted IDH Inhibitors (2019) (3)
The isolation of duplex DNA fragments containing (dG.dC) clusters by chromatography on poly(rC)-Sephadex. (1978) (3)
The structure and expression of mammalian gene clusters. (1982) (3)
Differential Requirements for NFk B and AP-1 transActivation in Response to Minimal TCR Engagement by a Partial Agonist in Naive CD 8 T Cells 1 (1999) (3)
Erratum: Bacterial flagellin stimulates Toll-like receptor 5-dependent defense against vancomycin-resistant Enterococcus infection (Journal of Infectious Diseases (2010) 201 (534-543)) (2010) (3)
A hierarchical GBP network promotes cytosolic LPS recognition and sepsis (2021) (3)
CFTR is a negative regulator of γδ T cell IFN-γ production and antitumor immunity (2020) (3)
The expression of cloned class I H-2b genes in L cells. (1983) (3)
Th17 cell plasticity towards a T-bet-dependent Th1 phenotype is required for bacterial control in Staphylococcus aureus infection (2022) (3)
Macrophage IL-12 p 70 Signaling Prevents HSV-1 – Induced CNS Autoimmunity Triggered by Autoaggressive CD 4 (2011) (3)
Humanized mouse models of infectious diseases (2012) (3)
Autocrine/paracrine TGF (cid:2) 1 is required for the development of epidermal Langerhans cells (2007) (2)
212: MAP kinase phosphatase 5 expression induced by influenza virus infection negatively regulates IRF3 activation and type I interferon response (2014) (2)
Commentary : Twisting the Th 1 / Th 2 immune response via the retinoid X receptor : Lessons from a genetic approach (2005) (2)
Transmissible inflammation-induced colorectal cancer in inflammasome-deficient mice (2019) (2)
Microbiota-driven interleukin-17-producing cells and eosinophils synergize to accelerate multiple myeloma progression (2018) (2)
Physical mapping of the globin gene deletion in (delta beta (0)) -thalassaemia. (1979) (2)
In Vivo Anti-Tumor Effect of PARP Inhibition in IDH1/2 Mutant MDS/AML Resistant to Targeted Inhibitors of Mutant IDH1/2 (2022) (2)
Expression Efficiency of Multiple Il9 Reporter Alleles Is Determined by Cell Lineage (2020) (2)
Requirement of JIP 1-Mediated c-Jun N-Terminal Kinase Activation for Obesity-Induced Insulin Resistance § (2017) (2)
Antiviral immunity: a link to bile acids (2019) (2)
Macrophage scavenger receptor 1 controls Chikungunya virus infection through autophagy in mice (2020) (2)
Autoinfl ammatory syndromes and infections : pathogenetic and clinical implications (2006) (2)
RNA methylation in immune cells. (2022) (2)
cGAS activation in phased droplets (2018) (2)
CD 8-Driven Virally Induced Model Absence of Detectable IL-17 A in a Development of Autoimmune Diabetes in the Juntti (2011) (2)
HIV-1 Vpu restricts Fc-mediated effector functions in vivo (2022) (2)
Intestinal Regulatory CD4+ T Cells (2015) (2)
TGFβ-Mediated Immunoregulation (2005) (2)
Erratum: Role of cathepsin S-dependent epithelial cell apoptosis in IFN-γ-induced alveolar remodeling and pulmonary emphysema (Journal of Immunology (2005) 174 (8106-8115)) (2005) (2)
Summary of Talk in Orlando Protection Against Insulin-Dependent Diabetes Mellitus (1993) (2)
The Structure of the Rabbit β-Globin Gene (1978) (2)
Mettl3 Mediated m6A Modification Is Essential in Fetal Hematopoiesis (2018) (2)
Gene Trajectory Inference for Single-cell Data by Optimal Transport Metrics (2023) (2)
Microglia Recognize Double-Stranded RNA (2013) (2)
Subsets of ILC3−ILC1-like cells generate a diversity spectrum of innate lymphoid cells in human mucosal tissues (2019) (2)
Publisher Correction: TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer (2020) (2)
Inhibition of Spirochete Transmission Expression and the burgdorferi bbk 32 Borrelia Arthropod-and Host-Specific Telford (2000) (2)
The analysis of gene expression in higher organisms (1980) (2)
Virus Infection by the Double-Stranded RNA Protective Immunity against Punta Toro TLR 3 Is Essential for the Induction of (2007) (2)
Corrigendum: Thymic self-reactivity selects natural interleukin 17–producing T cells that can regulate peripheral inflammation (2010) (1)
467 Aspirin Blocks Acetaminophen Induced Hepatotoxicity and Mortality in Mice - Dependent On the ASC/Caspase-1 Inflammasome (2008) (1)
Effector Memory Precursors A Pool of Central Memory-Like CD 4 T Cells (2003) (1)
Transcriptional activation ofHLA-DRa by interferon (1)
Evasion ofprotective immunity byBorrelia burgdorferi by truncation ofoutersurface protein B (1993) (1)
Membrane-cytoskeleton mechanical feedback mediated by myosin-I controls phagocytic efficiency (2018) (1)
Inflammasomes and Mucosal Immune Response (2013) (1)
Autoimmune ipr/lpr mice deficient in cd40 ligand: spontaneous immunoglobulin class switching with dichotomy of autoantibody responses (1996) (1)
Correction for Gyrd-Hansen et al., “Apoptosome-Independent Activation of the Lysosomal Cell Death Pathway by Caspase-9” (2017) (1)
Epiregulin is a dendritic cell-derived EGFR ligand that maintains skin and lung fibrosis. (2022) (1)
Regulation of the Activity of IFN-γ Promoter Elements During Th Cell Differentiation (1998) (1)
Natural sunscreen revealed (2001) (1)
Humanized Mouse Model of Myeloma Reveals Clinically Occult Genomic Changes in Primary Tumor Cells (2015) (1)
A transcription map for the rabbit beta-globin gene. (1981) (1)
Notice of redundant publicationDNA sequences required for regulated expression of β-globin genes in murine erythroleukaemia cells (2012) (1)
Lyme borreliosis in transgenic mice tolerant to OspA from Borrelia burgdorferi 25015. (1997) (1)
OR.28. Aluminum Hydroxide Adjuvants Activate the Immune System Through the Nalp3 Inflammasome (2009) (1)
Cytokine Regulation of Immune Tolerance to Tumors (2007) (1)
Distinct modes of mitochondrial metabolism uncouple T cell differentiation and function (2019) (1)
Niche-Dependent Growth of Malignant and Pre-Neoplastic Plasma Cells in Humanized Mice (2015) (1)
Cytokines in Health and Disease (2009) (1)
Molecular Cell Previews Resemble and Inhibit : When RLR Meets TGF-b (2014) (1)
Overcoming the hurdles in using mouse genetic models that block TGF- β signaling (2010) (1)
Map3k2-Regulated Intestinal Stromal Cells (MRISC) Define a Distinct Sub-cryptic Stem Cell Niche for Damage Induced Wnt Agonist R-spondin1 Production (2019) (1)
Mitochondrial Deoxyribonucleic AcidfromTetrahymena pyriformis and itsKinetic Complexity (1970) (1)
Cell Responses But Is Dispensable for CD 8 T Required for Generating Antiviral CD 4 T CD 40-CD 40 Ligand Costimulation Is (1999) (1)
Understanding the molecular bases of tissue inflammation (2010) (1)
Isolation and characterization of a human collagen alpha 1(I)-like gene from a cosmid library. (1982) (1)
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Peripheral T Cell Activation Program by Partial Agonist on Selection Events and Consequences of Intrathymic TCR Engagement (1998) (0)
Recent advances in Miscanthus science and breeding (2014) (0)
A special collection of reviews on frontiers in immunology (2020) (0)
Continuity and Change (2000) (0)
Conservation anddiversity intheclass Igenesofthemajor histocompatibili ty complex: Sequence analysis ofa Tiab geneandcomparison withaTlac gene (multigene family/thymus leukemia antigen/DNA sequence) (1986) (0)
Congress update (2007) (0)
MacrophagesDispensable for IL-33 Release by Caspase-1, Caspase-8, and Calpain Are (2009) (0)
Biophysical characterization of the conformational changes taking place on peroxin 14 implicated in the glycosomal translocation mechanism of the parasite Leishmania donovani (2009) (0)
Site-Directed Mutagenesis: Effect of an Ex In Vitro Propagation of Bacteriophage Q, (2016) (0)
Dominant-Negative Mice Receptor II b Biliary Cirrhosis in TGF-Anti-Mitochondrial Antibodies and Primary (2006) (0)
11 THE EXPRESSION OF TLR3 IS INCREASED IN ATHEROSCLEROSIS AND MEDIATES PROTECTION AGAINST LESION DEVELOPMENT AND WEIGHT GAIN IN APOE−/− MICE (2011) (0)
IL-18BP is a secreted immune checkpoint and barrier to IL-18 immunotherapy (2020) (0)
via TLR3 Microglia Recognize Double-Stranded RNA (2006) (0)
Cell to Induce X-Linked Immunodeficiency B and Synergizes with B Cell Receptor Signals Mitogen-Activated Protein Kinase Activation Positive Signaling Through CD72 Induces (2001) (0)
Requirement of voltage-gated calcium (Cav) channels in T cell receptor-mediated calcium response and effector functions of T lymphocytes (99.13) (2010) (0)
CD8 T cells Play a Critical Role in Primary Biliary Cirrhosis of dnTGFbetaRII Mice (2007) (0)
Abstract B088: Can the pro-tumorigenic activity of Th17 cells be a therapeutic opportunity? (2016) (0)
Deletion of IL-6 in a murine model of primary biliary cirrhosis leads to exacerbated autoimmune cholangitis and lymphomas (101.6) (2011) (0)
HepatitisInflammatory Regulation by TLR3 in Acute (0)
Infection Leishmania major Immunity Against JNK 1 Is Required for T Cell-Mediated (2000) (0)
JNK3 modulators and methods of use for (1998) (0)
This information is current as Candida albicans against Protective Antifungal Adaptive Immunity Cutting Edge : Nlrp 10 Is Essential for (2012) (0)
PART OF A SPECIAL ISSUE ON BIOBASED VALUE CHAINS FOR A GROWING BIOECONOMY (2018) (0)
Abstract 19446: Role of miR-181 Family in the Heart: A Tale of Two Intracellular Compartments (2015) (0)
Conservation and diversity in the class I genes of the major histocompatibility complex : Sequence analysis of a Tiab gene and comparison with a Tlac gene ( multigene family / thymus leukemia antigen / DNA sequence ) (2003) (0)
The eighteenth Colworth Medal Lecture. The globin genes of rabbit and man. (1983) (0)
Efficient Engraftment and Disease Replication of Myelodysplastic Syndromes Using a Novel Humanized Mice Model (2015) (0)
Abstract 309: Induction of activation-induced cytidine deaminase (AID) by dendritic cells leads to genomic instability in human myeloma (2012) (0)
Humanized mouse (PP-100) (2010) (0)
Charles A. Janeway, Jr. (1943-2003) (2003) (0)
Developing a Model of Human Pluripotent to Hematopoietic Stem Cell Development in Mistrg Mice (2015) (0)
Costimulator in Germinal Center Reactions Cutting Edge: Critical Role of Inducible (2001) (0)
IL-4 Production from Basophils IL-3-Induced M 2 Macrophages by Inhibiting SHIP Represses the Generation of Antov (2009) (0)
Require TLR Signaling In Vivo and Does Not Mycobacterium tuberculosis Production Is Critical for Host Resistance to β Cutting Edge : Caspase-1 Independent IL-1 Sutterwala and (2010) (0)
A protective role for toll-like receptor 3 but not toll-like receptor 7 in intimal hyperplasia (2011) (0)
Faculty Opinions recommendation of Doubling genome size without polyploidization: dynamics of retrotransposition-driven genomic expansions in Oryza australiensis, a wild relative of rice. (2006) (0)
TGF-beta and TH17 Cells (2011) (0)
Contains Effector Memory Precursors A Pool of Central Memory-Like CD4 T Cells (2013) (0)
A highly efficient and faithful MDS patient-derived xenotransplantation model for pre-clinical studies (2019) (0)
P-225 Modeling of myelodysplasia in a humanized immunodeficient mouse model (2013) (0)
Caspase-9 deficiency enhances type I interferon production and confers resistance to viral infection (105.1) (2011) (0)
Interleukin-17A is not produced by T cells during anti-viral immunity and autoimmunity in a model of virus-induced autoimmune diabetes (2010) (0)
Paracrine orchestration of intestinal tumorigenesis by a mesenchymal niche (2020) (0)
HOW AUTOREACTIVE B CELLS ARE ACTIVATED (2010) (0)
Essential role of Cavβ2 in T Cell development and homeostasis. (LYM7P.715) (2014) (0)
THE STRUCTURE OF CLONED RABBIT AND MOUSE β-GLOBIN GENES (1979) (0)
Molecular Mechanisms of RNA Sensing in NLRP6 Inflammasome Signaling (2020) (0)
Adaptive Immunity Infection through Defective Innate and Mycobacterium tuberculosis Resistance to NOD 2-Deficient Mice Have Impaired (2008) (0)
Immunity to virus infection (excluding retroviruses) 1 (WS-025a) Chairpersons: Yusuke Yanagi, Nicholas King (2010) (0)

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