Richard J. Youle
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Richard J. Youle's Degrees
- PhD Biochemistry University of California, Berkeley
- Bachelors Chemistry University of California, Berkeley
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(Suggest an Edit or Addition)Richard J. Youle's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The BCL-2 protein family: opposing activities that mediate cell death (2008) (4302)
- Parkin is recruited selectively to impaired mitochondria and promotes their autophagy (2008) (3424)
- Mechanisms of mitophagy (2010) (2621)
- Mitochondrial Fission, Fusion, and Stress (2012) (2481)
- PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin (2010) (2399)
- Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes (2009) (2078)
- Movement of Bax from the Cytosol to Mitochondria during Apoptosis (1997) (1925)
- The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy (2015) (1750)
- The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis. (2001) (1661)
- The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease (2015) (1483)
- Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics. (2011) (1241)
- Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin (2010) (1200)
- Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis. (1997) (1200)
- Mitochondrial dynamics and apoptosis. (2008) (1160)
- Structure of Bax Coregulation of Dimer Formation and Intracellular Localization (2000) (1113)
- Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL (2010) (1054)
- The role of mitochondria in apoptosis*. (2009) (1026)
- Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis. (2004) (1014)
- Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance (2018) (980)
- PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity (2014) (952)
- Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells (2010) (924)
- The Mitochondrial Basis of Aging. (2016) (840)
- Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis (2002) (803)
- Conformation of the Bax C‐terminus regulates subcellular location and cell death (1999) (746)
- Mitochondrial fission in apoptosis (2005) (735)
- Dynamics of mitochondrial morphology in healthy cells and during apoptosis (2003) (725)
- p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both (2010) (717)
- Parkin and PINK1 mitigate STING-induced inflammation (2018) (708)
- SLP‐2 is required for stress‐induced mitochondrial hyperfusion (2009) (649)
- Nitric oxide‐induced mitochondrial fission is regulated by dynamin‐related GTPases in neurons (2006) (644)
- Role of Bax and Bak in mitochondrial morphogenesis (2006) (615)
- Nonionic Detergents Induce Dimerization among Members of the Bcl-2 Family* (1997) (610)
- JNK-Mediated BIM Phosphorylation Potentiates BAX-Dependent Apoptosis (2003) (574)
- Bax in Murine Thymus Is a Soluble Monomeric Protein That Displays Differential Detergent-induced Conformations* (1998) (542)
- Tumor regression with regional distribution of the targeted toxin TF-CRM107 in patients with malignant brain tumors (1997) (529)
- Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase Parkin. (2012) (527)
- Bcl-xL Retrotranslocates Bax from the Mitochondria into the Cytosol (2011) (511)
- Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria (2016) (501)
- Bax and Bak Coalesce into Novel Mitochondria-Associated Clusters during Apoptosis (2001) (492)
- Drp-1-dependent division of the mitochondrial network blocks intraorganellar Ca2+ waves and protects against Ca2+-mediated apoptosis. (2004) (480)
- PINK1 is degraded through the N-end rule pathway (2013) (471)
- PINK1- and Parkin-mediated mitophagy at a glance (2012) (469)
- Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosis (2004) (435)
- The mitochondrial E3 ubiquitin ligase MARCH5 is required for Drp1 dependent mitochondrial division (2007) (430)
- Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak‐mediated permeabilization (2003) (419)
- p38 Map Kinase Mediates Bax Translocation in Nitric Oxide–Induced Apoptosis in Neurons (2000) (400)
- Control of mitochondrial permeability by Bcl-2 family members. (2004) (395)
- Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells (2003) (386)
- Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration (2012) (353)
- In situ labeling of granule cells for apoptosis-associated DNA fragmentation reveals different mechanisms of cell loss in developing cerebellum (1993) (346)
- Targeting mitochondrial dysfunction: role for PINK1 and Parkin in mitochondrial quality control. (2011) (332)
- OPA1 mutations associated with dominant optic atrophy impair oxidative phosphorylation and mitochondrial fusion. (2008) (324)
- The accumulation of misfolded proteins in the mitochondrial matrix is sensed by PINK1 to induce PARK2/Parkin-mediated mitophagy of polarized mitochondria (2013) (322)
- High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy (2013) (300)
- Mitochondrial fission facilitates the selective mitophagy of protein aggregates (2017) (294)
- Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells (2010) (293)
- How do Bax and Bak lead to permeabilization of the outer mitochondrial membrane? (2006) (286)
- Bax, but not Bcl-xL, decreases the lifetime of planar phospholipid bilayer membranes at subnanomolar concentrations. (1999) (281)
- Mitochondrial quality control mediated by PINK1 and Parkin: links to parkinsonism. (2012) (280)
- The permeability transition pore signals apoptosis by directing Bax translocation and multimerization (2002) (268)
- Mitochondrial Function, Biology, and Role in Disease: A Scientific Statement From the American Heart Association. (2016) (266)
- Endophilin B1 is required for the maintenance of mitochondrial morphology (2004) (260)
- Endogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic Stress (2015) (257)
- Mitochondrial Fission and Fusion Mediators, hFis1 and OPA1, Modulate Cellular Senescence* (2007) (257)
- Spatiotemporal Control of ULK1 Activation by NDP52 and TBK1 during Selective Autophagy (2019) (255)
- A Study of the Interferon Antiviral Mechanism: Apoptosis Activation by the 2–5A System (1997) (254)
- Self and nonself: how autophagy targets mitochondria and bacteria. (2014) (250)
- PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding (2013) (229)
- Mitochondrial Rab GAPs govern autophagosome biogenesis during mitophagy (2014) (224)
- Parkin-induced mitophagy in the pathogenesis of Parkinson disease (2009) (221)
- Apoptosis and DNA degradation induced by 1-methyl-4-phenylpyridinium in neurons. (1991) (218)
- Regulating mitochondrial outer membrane proteins by ubiquitination and proteasomal degradation. (2011) (217)
- MiT/TFE transcription factors are activated during mitophagy downstream of Parkin and Atg5 (2015) (215)
- A chemical inhibitor of DRP1 uncouples mitochondrial fission and apoptosis. (2008) (212)
- A cytotoxic ribonuclease. Study of the mechanism of onconase cytotoxicity. (1993) (212)
- The soluble form of Bax regulates mitochondrial fusion via MFN2 homotypic complexes. (2011) (211)
- Hsp90-Cdc37 chaperone complex regulates Ulk1- and Atg13-mediated mitophagy. (2011) (208)
- Loss of MARCH5 mitochondrial E3 ubiquitin ligase induces cellular senescence through dynamin-related protein 1 and mitofusin 1 (2010) (201)
- Bid, but Not Bax, Regulates VDAC Channels* (2004) (201)
- Cytomegalovirus cell death suppressor vMIA blocks Bax- but not Bak-mediated apoptosis by binding and sequestering Bax at mitochondria. (2004) (200)
- PINK1 import regulation; a fine system to convey mitochondrial stress to the cytosol (2018) (195)
- Loss of Bif-1 Suppresses Bax/Bak Conformational Change and Mitochondrial Apoptosis (2005) (192)
- OCCURRENCE OF LOW MOLECULAR WEIGHT AND HIGH CYSTEINE CONTAINING ALBUMIN STORAGE PROTEINS IN OILSEEDS OF DIVERSE SPECIES (1981) (191)
- Bax translocation to mitochondria subsequent to a rapid loss of mitochondrial membrane potential (2001) (184)
- The role of 2′-5′ oligoadenylate-activated ribonuclease L in apoptosis (1998) (183)
- Mutations in Fis1 disrupt orderly disposal of defective mitochondria (2014) (177)
- Anti-Thy 1.2 monoclonal antibody linked to ricin is a potent cell-type-specific toxin. (1980) (176)
- Parkin is a lipid-responsive regulator of fat uptake in mice and mutant human cells. (2011) (176)
- Mitochondria in Ca2+ Signaling and Apoptosis (2000) (172)
- EX-VIVO TREATMENT OF DONOR BONE MARROW WITH ANTI-T-CELL IMMUNOTOXINS FOR PREVENTION OF GRAFT-VERSUS-HOST DISEASE (1984) (169)
- Kinetics of protein synthesis inactivation by ricin-anti-Thy 1.1 monoclonal antibody hybrids. Role of the ricin B subunit demonstrated by reconstitution. (1982) (164)
- The solution structure of human mitochondria fission protein Fis1 reveals a novel TPR-like helix bundle. (2003) (164)
- Mutations in diphtheria toxin separate binding from entry and amplify immunotoxin selectivity. (1987) (163)
- Role of the N terminus in RNase A homologues: differences in catalytic activity, ribonuclease inhibitor interaction and cytotoxicity. (1996) (162)
- Bcl‐xL sequesters its C‐terminal membrane anchor in soluble, cytosolic homodimers (2004) (159)
- Mitochondrial fission and fusion. (2010) (153)
- Anti-T-cell reagents for human bone marrow transplantation: ricin linked to three monoclonal antibodies. (1983) (142)
- Angiogenin is a cytotoxic, tRNA-specific ribonuclease in the RNase A superfamily. (1992) (142)
- Which came first, the cytochrome c release or the mitochondrial fission? (2006) (134)
- Mitochondria, calcium and pro-apoptotic proteins as mediators in cell death signaling. (2003) (129)
- Role of Mitochondrial Remodeling in Programmed Cell Death in Drosophila melanogaster (2007) (126)
- Protein Bodies from the Endosperm of Castor Bean: Subfractionation, Protein Components, Lectins, and Changes during Germination. (1976) (122)
- Efficacy of direct intratumoral therapy with targeted protein toxins for solid human gliomas in nude mice. (1994) (117)
- Apoptosis and Free Radicals (1994) (115)
- The 2-5A system in viral infection and apoptosis. (1998) (115)
- Polyubiquitin-sensor proteins reveal localization and linkage-type dependence of cellular ubiquitin signaling (2012) (109)
- Improved tumor-specific immunotoxins in the treatment of CNS and leptomeningeal neoplasia. (1989) (107)
- Molecular Cloning of ILP-2, a Novel Member of the Inhibitor of Apoptosis Protein Family (2001) (106)
- Atypical mitochondrial fission upon bacterial infection (2013) (105)
- Bcl-2 family interaction with the mitochondrial morphogenesis machinery (2011) (102)
- Monoclonal Antibody‐Ricin or Ricin A Chain Hybrids: Kinetic Analysis of Cell Killing for Tumor Therapy (1982) (101)
- Mitochondria—Striking a balance between host and endosymbiont (2019) (100)
- Entry into Cells and Selective Degradation of tRNAs by a Cytotoxic Member of the RNase A Family* (2002) (100)
- Predominant requirement of Bax for apoptosis in HCT116 cells is determined by Mcl-1’s inhibitory effect on Bak (2011) (100)
- Vps13D Encodes a Ubiquitin-Binding Protein that Is Required for the Regulation of Mitochondrial Size and Clearance (2018) (97)
- A Study of the Intracellular Routing of Cytotoxic Ribonucleases (*) (1995) (97)
- Involvement of mitochondrial dynamics in the segregation of mitochondrial matrix proteins during stationary phase mitophagy (2013) (96)
- Endosomal Rab cycles regulate Parkin-mediated mitophagy (2018) (94)
- Reciprocal Roles of Tom7 and OMA1 during Mitochondrial Import and Activation of PINK1. (2019) (92)
- Inhibition of HIV-1 Production and Selective Degradation of Viral RNA by an Amphibian Ribonuclease* (1996) (91)
- Role of Membrane Association and Atg14-Dependent Phosphorylation in Beclin-1-Mediated Autophagy (2013) (91)
- Instability of the Mitofusin Fzo1 Regulates Mitochondrial Morphology during the Mating Response of the Yeast Saccharomyces cerevisiae* (2005) (89)
- Hybridoma cells containing intracellular anti-ricin antibodies show ricin meets secretory antibody before entering the cytosol. (1987) (85)
- Potent and specific killing of human malignant brain tumor cells by an anti-transferrin receptor antibody-ricin immunotoxin. (1987) (82)
- Use of multiple T cell-directed intact ricin immunotoxins for autologous bone marrow transplantation. (1985) (82)
- Studies on the galactose-binding site of ricin and the hybrid toxin man6P-ricin (1981) (80)
- Cytotoxic potential of ribonuclease and ribonuclease hybrid proteins. (1991) (80)
- The role of the diphtheria toxin receptor in cytosol translocation. (1988) (79)
- Comparison of RNases and toxins upon injection into Xenopus oocytes. (1991) (77)
- Role of the Ubiquitin Conjugation System in the Maintenance of Mitochondrial Homeostasis (2008) (76)
- Mitochondrial damage-associated inflammation highlights biomarkers in PRKN/PINK1 parkinsonism (2020) (76)
- Graft-versus-host disease prevention in allogeneic bone marrow transplantation from histocompatible siblings. A pilot study using immunotoxins for T cell depletion of donor bone marrow. (1987) (76)
- Intraventricular immunotoxin therapy for leptomeningeal neoplasia. (1997) (75)
- Ricin subunit association. Thermodynamics and the role of the disulfide bond in toxicity. (1986) (75)
- Cell surface and intracellular functions for ricin galactose binding. (1992) (75)
- Combined ex vivo treatment with immunotoxins and mafosfamid: a novel immunochemotherapeutic approach for elimination of neoplastic T cells from autologous marrow grafts. (1985) (74)
- Pseudomonas Exotoxin A-Mediated Apoptosis Is Bak Dependent and Preceded by the Degradation of Mcl-1 (2010) (74)
- Bone marrow transplantation across major histocompatibility barriers. V. Protection of mice from lethal graft-vs.-host disease by pretreatment of donor cells with monoclonal anti-Thy-1.2 coupled to the toxin ricin (1982) (72)
- Cytomegalovirus Proteins vMIA and m38.5 Link Mitochondrial Morphogenesis to Bcl-2 Family Proteins (2008) (71)
- Novel Structure of the N Terminus in Yeast Fis1 Correlates with a Specialized Function in Mitochondrial Fission* (2005) (69)
- Pharmacokinetic analysis of immunotoxin uptake in solid tumors: role of plasma kinetics, capillary permeability, and binding. (1990) (69)
- Expression and characterization of recombinant human eosinophil-derived neurotoxin and eosinophil-derived neurotoxin-anti-transferrin receptor sFv. (1994) (68)
- Engineering receptor-mediated cytotoxicity into human ribonucleases by steric blockade of inhibitor interaction (1999) (67)
- SnapShot: BCL-2 Proteins (2009) (67)
- X-ray crystallographic structure of recombinant eosinophil-derived neurotoxin at 1.83 A resolution. (1996) (66)
- Molecular and topological reorganizations in mitochondrial architecture interplay during Bax-mediated steps of apoptosis (2018) (66)
- RNase inhibition of human immunodeficiency virus infection of H9 cells. (1994) (65)
- IBRDC2, an IBR‐type E3 ubiquitin ligase, is a regulatory factor for Bax and apoptosis activation (2010) (64)
- Humanization of immunotoxins. (1992) (62)
- Ubiquitin ligase RNF167 regulates AMPA receptor-mediated synaptic transmission (2012) (61)
- Albumin storage proteins in the protein bodies of castor bean. (1978) (61)
- Vascular protection by chloroquine during brain tumor therapy with Tf-CRM107. (2000) (60)
- A Systematic Search for Endoplasmic Reticulum (ER) Membrane-associated RING Finger Proteins Identifies Nixin/ZNRF4 as a Regulator of Calnexin Stability and ER Homeostasis* (2011) (59)
- Cellular Demolition and the Rules of Engagement (2007) (59)
- Outer mitochondrial membrane protein degradation by the proteasome. (2010) (59)
- Cytotoxic ribonuclease chimeras. Targeted tumoricidal activity in vitro and in vivo. (1992) (56)
- The mannose 6-phosphate receptor of Chinese Hamster ovary cells. Isolation of mutants with altered receptors. (1981) (56)
- Conformation of BCL-XL upon Membrane Integration. (2015) (56)
- Molecular determinants in the plasma clearance and tissue distribution of ribonucleases of the ribonuclease A superfamily. (1996) (56)
- Cytotoxic ribonucleases and chimeras in cancer therapy. (1993) (53)
- Cloned fragment of diphtheria toxin linked to T cell-specific antibody identifies regions of B chain active in cell entry. (1986) (52)
- Structural mechanism of Bax inhibition by cytomegalovirus protein vMIA (2012) (51)
- ULK complex organization in autophagy by a C-shaped FIP200 N-terminal domain dimer (2019) (51)
- Efficacy of intrathecal immunotoxin therapy in an animal model of leptomeningeal neoplasia. (1988) (51)
- PINK1/Parkin Influences Cell Cycle by Sequestering TBK1 at Damaged Mitochondria, Inhibiting Mitosis (2019) (50)
- Jak3-Independent Trafficking of the Common γ Chain Receptor Subunit: Chaperone Function of Jaks Revisited (2004) (49)
- PINK 1 Is Selectively Stabilized on Impaired Mitochondria to Activate (2010) (49)
- STING induces LC3B lipidation onto single-membrane vesicles via the V-ATPase and ATG16L1-WD40 domain (2020) (48)
- Identification and characterization of a monoclonal antibody recognizing a galactose-binding domain of the toxin ricin. (1987) (48)
- Albumin storage protein and allergens in cottonseeds. (1979) (48)
- Retinoic acid disrupts the Golgi apparatus and increases the cytosolic routing of specific protein toxins (1994) (48)
- Ricin linked to monophosphopentamannose binds to fibroblast lysosomal hydrolase receptors, resulting in a cell-type-specific toxin. (1979) (48)
- Chemogenomic profiling of endogenous PARK2 expression using a genome-edited coincidence reporter. (2015) (47)
- Inhibition of Axotomy-induced Neuronal Apoptosis by Extracellular Delivery of a Bcl-XL Fusion Protein* (2001) (47)
- Organelle-specific Isozymes of Aspartate-α-Ketoglutarate Transaminase in Spinach Leaves (1976) (46)
- Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain. (2020) (46)
- Mitochondrial fission and fusion and their roles in the heart (2010) (45)
- Mitochondrial Quality Control and Restraining Innate Immunity. (2020) (45)
- Epidermal growth factor receptors on ependymomas and other brain tumors. (1990) (44)
- The spatial distribution of immunotoxins in solid tumors: assessment by quantitative autoradiography. (1993) (43)
- Coupling mitochondrial and cell division (2011) (42)
- Characterization of the mechanism of cellular and cell free protein synthesis inhibition by an anti-tumor ribonuclease. (1994) (41)
- 15 – Antitumor RNases (1997) (40)
- Characterization of single-chain antibody (sFv)-toxin fusion proteins produced in vitro in rabbit reticulocyte lysate. (1993) (40)
- Purification of beta-glucocerebrosidase by preparative-scale high-performance liquid chromatography: the use of ethylene glycol-containing buffers for chromatography of hydrophobic glycoprotein enzymes. (1985) (40)
- Whole ricin and recombinant ricin A chain idiotype-specific immunotoxins for therapy of the guinea pig L2C B cell leukemia. (1987) (40)
- Immunotoxins show rapid entry of diphtheria toxin but not ricin via the T3 antigen. (1986) (39)
- Fluorescence‐based ATG8 sensors monitor localization and function of LC3/GABARAP proteins (2017) (39)
- Bax Activates Endophilin B1 Oligomerization and Lipid Membrane Vesiculation* (2009) (38)
- Caspase inhibition prevents the mitochondrial release of apoptosis-inducing factor (2003) (38)
- Mapping the Ribonucleolytic Active Site of Eosinophil-derived Neurotoxin (EDN) (2001) (37)
- PINK1 and Parkin Flag Miro to Direct Mitochondrial Traffic (2011) (37)
- Elimination of clonogenic T-leukemic cells from human bone marrow using anti-Mr 65,000 protein immunotoxins. (1984) (37)
- The role of proline 345 in diphtheria toxin translocation. (1993) (35)
- A clinically complex form of dominant optic atrophy (OPA8) maps on chromosome 16. (2011) (35)
- Evidence that the castor bean allergens are the albumin storage proteins in the protein bodies of castor bean. (1978) (34)
- Pharmacokinetics and toxicology of immunotoxins administered into the subarachnoid space in nonhuman primates and rodents. (1993) (34)
- Immunotoxins for central nervous system malignancy. (1996) (33)
- Programmed cell death in heterokaryons. A study of the transfer of apoptosis between nuclei. (1992) (32)
- Image-based pooled whole-genome CRISPRi screening for subcellular phenotypes (2021) (31)
- VPS13D promotes peroxisome biogenesis (2021) (30)
- Morphology of mitochondria during apoptosis: worms-to-beetles in worms. (2005) (29)
- Anti-T cell monoclonal antibodies conjugated to ricin as potential reagents for human GVHD prophylaxis: effect on the generation of cytotoxic T cells in both peripheral blood and bone marrow. (1984) (29)
- Receptor-mediated transport of the hybrid protein ricin-diphtheria toxin fragment A with subsequent ADP-ribosylation of intracellular elongation factor II. (1979) (29)
- Cell biology: Form follows function for mitochondria (2016) (27)
- Skeletal muscle‐specific immunotoxin for the treatment of focal muscle spasm (1998) (27)
- Ex vivo T cell depletion with immunotoxins in allogeneic bone marrow transplantation: The pilot clinical study for prevention of graft-versus-host disease (1985) (27)
- Deleterious mitochondrial DNA point mutations are overrepresented in Drosophila expressing a proofreading-defective DNA polymerase γ (2018) (27)
- Suppression of the immune response to immunotoxins with anti-CD4 monoclonal antibodies. (1991) (26)
- Cell biology. Cellular demolition and the rules of engagement. (2007) (26)
- Ubiquitin signaling in neurodegenerative diseases: an autophagy and proteasome perspective (2020) (25)
- Diphtheria toxin effects on brain-tumor xenografts. Implications for protein-based brain-tumor chemotherapy. (1990) (25)
- Monoclonal antibody toxin conjugates for experimental graft-versus-host disease prophylaxis. Reagents selectively reactive with T cells and not murine stem cells. (1983) (25)
- Diphtheria toxin mutant selectively kills cerebellar Purkinje neurons. (1990) (24)
- Outer Mitochondrial Membrane Protein Degradation by the Proteasome (2007) (24)
- Clinical use of immunotoxins : monoclonal antibodies conjugated to protein toxins (1991) (24)
- PINK1 rendered temperature sensitive by disease-associated and engineered mutations. (2013) (23)
- Neurodegeneration: Trouble in the cell's powerhouse (2012) (22)
- The mechanisms and roles of selective autophagy in mammals (2022) (22)
- Comparison of protein synthesis inhibition kinetics and cell killing induced by immunotoxins. (1991) (21)
- Hsp 90-Cdc 37 Chaperone Complex Regulates Ulk 1-and Atg 13-Mediated Mitophagy (2012) (21)
- Scission, spores, and apoptosis: a proposal for the evolutionary origin of mitochondria in cell death induction. (2003) (21)
- Long-term effects of ricin-mAb 35 on extraocular muscles of rabbits: potential treatment for strabismus. (2002) (21)
- Characterization of the membrane-inserted C-terminus of cytoprotective BCL-XL. (2016) (20)
- Acute effects of the skeletal muscle-specific immunotoxin ricin-mAb 35 on extraocular muscles of rabbits. (2000) (20)
- Immunotoxins for brain tumor therapy. (1998) (20)
- Extracellular Bad fused to toxin transport domains induces apoptosis. (2002) (19)
- Cytotoxic Onconase and Ribonuclease A Chimeras: Comparison and in Vitro Characterization (1993) (18)
- Development and properties of fructose 1,6-bisphosphatase in the endosperm of castor-bean seedlings. (1976) (18)
- A point mutation of proline 308 in diphtheria toxin B chain inhibits membrane translocation of toxin conjugates. (1989) (17)
- Two different axes CALCOCO2-RB1CC1 and OPTN-ATG9A initiate PRKN-mediated mitophagy (2020) (16)
- Parkin and PINK1 mitigate STING-induced inflammation (2018) (16)
- Endosome fusion induced by diphtheria toxin translocation domain (2008) (15)
- Neurolastin, a Dynamin Family GTPase, Regulates Excitatory Synapses and Spine Density. (2015) (14)
- Receptor-mediated uptake of an extracellular Bcl-x(L) fusion protein inhibits apoptosis. (1999) (13)
- Organelle-specific Isozymes of Aspartate-alpha-Ketoglutarate Transaminase in Spinach Leaves. (1976) (12)
- A chimeric protein induces tumor cell apoptosis by delivering the human Bcl-2 family BH3-only protein Bad. (2005) (12)
- Parkin mediates mitophagy during beige-to-white fat conversion (2018) (12)
- Mitochondrial Disease: mtDNA and Protein Segregation Mysteries in iPSCs (2013) (12)
- The Cytokine, Granulocyte-Macrophage Colony-stimulating Factor (GM-CSF), Can Deliver Bcl-XL as an Extracellular Fusion Protein to Protect Cells from Apoptosis and Retain Differentiation Induction* (2007) (12)
- Interferon enhances the activity of the anticancer ribonuclease, onconase. (1999) (12)
- Mitochondrial fi ssion and fusion (2010) (8)
- Selective autophagic clearance of protein aggregates is mediated by the autophagy receptor, TAX1BP1 (2019) (8)
- Genetic engineering of immunotoxins. (1988) (8)
- Fluorescence-based ATG 8 sensors monitor localization and function of LC 3 / GABARAP proteins (2016) (8)
- Bcl-xL and caspase inhibition increase the survival of rat oxytocin and vasopressin magnocellular neurons in organotypic culture (2006) (7)
- Balancing cell growth and death. (2012) (6)
- Monoclonal antibodies and immunotoxins in bone marrow transplantation: purging marrow of ALL or GVHD cells with preservation of stem cells. (1985) (6)
- Monoclonal Antibodies for Purging Bone Marrow of Acute Lymphoblastic Leukemia or Graft Versus Host Producing Cells:Antibody Plus Complement or Immunotoxins (1984) (6)
- Sequestration and autophagy of mitochondria do not cut proteins across the board (2013) (5)
- Humanized immunotoxins. (1994) (5)
- The structure of Pseudomonas exotoxin A as a guide to rational design. (1992) (4)
- The structure of diphtheria toxin as a guide to rational design. (1992) (4)
- Image-based pooled whole genome CRISPR screening for Parkin and TFEB subcellular localization (2020) (4)
- Neurotoxicity of immunotoxins (1994) (4)
- Make or break for mitochondria (2013) (4)
- Rational immunotherapy with ribonuclease chimeras (1992) (4)
- Receptor-mediated uptake of an extracellular Bcl-xL fusion protein inhibits apoptosis (diphtheria toxinyBaxyBcl-2yimmunotoxinyendocytosis) (1999) (3)
- Fatal attraction in vitro and in vivo. (1988) (3)
- Generation and Characterization of Species-Specific Anti-Bcl-XL Monoclonal Antibodies (2003) (3)
- Mutations in diphtheria toxin to improve immunotoxin selectivity and understand toxin entry into cells. (1991) (3)
- Rational immunotherapy with ribonuclease chimeras. An approach toward humanizing immunotoxins. (1992) (3)
- P/14 The Bcl-2 family and mitochondria: In sickness and in health (2008) (2)
- Mitochondrial Metabolism , Sirtuins , and Aging Subject Collection Mitochondria Mitochondrial Metabolism , Sirtuins , and Aging (2012) (2)
- Generation and characterization of species-specific anti-Bcl-X(L) monoclonal antibodies. (2003) (2)
- Active state of Parkin (2018) (2)
- Neurolastin, a dynamin family GTPase, translocates to mitochondria upon neuronal stress and alters mitochondrial morphology in vivo (2019) (2)
- Therapy for mitochondrial diseases: An investigation into the potential to stimulate Parkin-mediated mitophagy (2013) (1)
- Ribosome inactivating enzymes in castor bean and man. (1996) (1)
- Supplemental Data Drp-1-Dependent Division of the Mitochondrial Network Blocks Intraorganellar Ca (2009) (1)
- Faculty Opinions recommendation of A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis. (2002) (1)
- MITCHELL MEDAL LECTURE (2006) (1)
- IgE-immunotoxins. II. IgE-ricin A-chain. (1987) (1)
- Eosinophil-derived Neurotoxin (EDN) - Sulphate Complex (2001) (1)
- Autophagy Functions Of Genes Mutated In ALS And Parkinson’s Disease (2017) (1)
- Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain. (2022) (1)
- Solution structure of human mitochondria fission protein Fis1 (2003) (1)
- Sequence-specific 1H, 13C and 15N resonance assignments of recombinant onconase/P-30 protein. (1999) (1)
- TNIP1 inhibits Mitophagy via interaction with FIP200 and TAX1BP1 (2022) (1)
- S9.4 Altered mitochondrial dynamics caused by loss of PTEN-induced kinase 1 function, associated with recessive parkinsonism, are reversed by downregulation of Dynamin-related protein 1 (2008) (1)
- Preparation and use of anti-idiotypic antibodies armed with holotoxins or hemitoxins in treatment of B-cell neoplasms. (1989) (1)
- Letter to the Editor: Sequence-specific 1H, 13C and 15N resonance assignments of recombinant onconase/P-30 protein (1999) (1)
- The molecular interrelationships between mitochondrial morphogenesis and apoptosis (2007) (1)
- Faculty Opinions recommendation of Correlated three-dimensional light and electron microscopy reveals transformation of mitochondria during apoptosis. (2007) (1)
- Toxin selection and modification--overview. (1988) (1)
- Author response: Mitochondrial Rab GAPs govern autophagosome biogenesis during mitophagy (2014) (1)
- Long-Term Kinetics of Antibody-Toxin Conjugates Show Resistant Cells (1984) (1)
- Bax, a Death Effector Molecule (1999) (0)
- Fluorescence based studies of endophilin B proteins and their interactions with lipid membranes (2007) (0)
- TNIP 1 inhibits Mitophagy via interaction with FIP 200 and 1 TAX 1 BP 1 2 3 (2022) (0)
- Acute Manipulation of Outer Membrane Phospholipid Composition Directly Alters Mitochondrial Dynamics and Ultrastructure (2022) (0)
- 103The role of Parkin in the clearance of defective mitochondria with deleted mtDNA in the CNS (2013) (0)
- Active state of Parkin (2018) (0)
- the endoplasmic reticulum and a variety of enzymes. (2013) (0)
- Faculty Opinions recommendation of JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins. (2004) (0)
- Autophagy machinery genes are differentially required for autophagy and Parkin-mediated mitophagy (2016) (0)
- State of GTPase cycle dictates mobility and localization of large mitochondrial GTPases, Mfn1 and 2 (2007) (0)
- Abstract 2350: Loss of Sting in parkin mutant flies suppresses muscle defects and underlying mitochondria damage through induction of pro-survival genes (2023) (0)
- Mitochondrial Dynamics in the Photoreceptors of Hibernating Ground Squirrels (2012) (0)
- Clinical Use of Immunotoxins (1991) (0)
- Jak3-Independent Trafficking of the Common (cid:2) Chain Receptor Subunit: Chaperone Function of Jaks Revisited (2004) (0)
- Expression and Characterization of Recombinant Human Eosinophil-derived Neurotoxin and Eosinophil-derived (1994) (0)
- Faculty Opinions recommendation of Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion. (2004) (0)
- PINK1 selectively accumulates on depolarized mitochondria. (2010) (0)
- Faculty Opinions recommendation of Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes. (2005) (0)
- Chapter 3 – IMMUNOLOGICAL APPROACHES TO THE IDENTIFICATION OF CELL-SURFACE-SPECIFIC ANTIGENS IN BRAIN (1988) (0)
- Damage control — How the PINK1/Parkin pathway can regulate removal of impaired mitochondria by autophagy (2012) (0)
- Towards and understanding of the role of Bax on bile acid-mediated cytoprotection (2019) (0)
- Mitophagy as a quality control mechanism in Saccharomyces cerevisiae (2013) (0)
- Faculty Opinions recommendation of Processing of Mgm1 by the rhomboid-type protease Pcp1 is required for maintenance of mitochondrial morphology and of mitochondrial DNA. (2003) (0)
- Prevention of gvhd across major h-2 barriers by pretreatment of donor lymphophematopoietic grafts with monoclonal anti- -thy-1.2 Linked ricin. Abstr. (1982) (0)
- Calnexin levels are regulated by the ER localized ubiquitin ligase Nixin (2011) (0)
- Mitochondria in Parkinson’s disease (2019) (0)
- Fis 1 governs normal mitophagy in slow muscle during the low-intensity and long-period exercise (2018) (0)
- Binding of Pro-Apoptotic Protein Bax to Cytoprotective UDCA and TUDCA (2015) (0)
- P25 Clearing cells of mutant mitochondrial DNA by restricting glycolysis (2014) (0)
- TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1. (2023) (0)
- Patents and literature (1985) (0)
- PINK1 import regulation; a fine system to convey mitochondrial stress to the cytosol (2018) (0)
- Use of Monoclonal Antibody-Intact Ricin Conjugates in Experimental Allogeneic Bone Marrow Transplantation (1984) (0)
- Chimeric Toxins: Mechanisms of Action and Therapeutic Applications (Cell and Molecular Mechanisms of Toxin Action) (2003) (0)
- The Discovery of 2S Albumins as Abundant Storage Proteins in Seeds (2000) (0)
- Monoclonal antibodies and immobilized antibodies (1987) (0)
- Directed entry of hybrid proteins into cells via alternative receptors. (1980) (0)
- Disease -Related Mitochondrial POLG Clinical and Molecular Features of (2013) (0)
- Role of the mitochondrial kinase Pink1 in Parkin recruitment and mitophagy (2010) (0)
- Advances in Brief Vascular Protection by Chloroquine during Brain Tumor Therapy with Tf-CRM 107 (2000) (0)
- Mitochondria : a subject collection from Cold Spring Harbor perspectives in biology (2014) (0)
- Eosinophil-derived Neurotoxin (EDN) - Adenosien-3'-5'-Diphosphate Complex (2001) (0)
- Mitochondrial morphology is regulated by RING domain proteins. (2007) (0)
- PO-125 Fis1 governs normal mitophagy in slow muscle during the low-intensity and long-period exercise (2018) (0)
- Structural Insights into Cytomegalovirus Resistance to Apoptosis (2011) (0)
- A role for mitochondrial dynamics in the segregation of mitochondrial matrix proteins during stationary phase mitophagy (557.1) (2014) (0)
- A novel mitochondrial ubiquitin ligase involved in the regulation of mitochondrial fusion (2012) (0)
- Faculty Opinions recommendation of Reducing mitochondrial fission results in increased life span and fitness of two fungal ageing models. (2007) (0)
- In Vitro and In Vivo Efficacy of a New Immunotoxin, 5E9-RNAse, in the Treatment of Human Gliomas (1992) (0)
- S9.8 Mitofusin foci: Endogenous localization and apoptotic behavior (2008) (0)
- SOLUTION STRUCTURE OF A PRO-APOPTOTIC PROTEIN BAX (2000) (0)
- Impairment of mitochondrial fusion in dominant optic atrophy, a model for selective neurodegeneration (2006) (0)
- Mitochondria and peroxisomes are NIXed for clearance (2022) (0)
- Roles of endogenous PINK1 and Parkin in vivo – a different type of mitochondrial QC (2018) (0)
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What Schools Are Affiliated With Richard J. Youle?
Richard J. Youle is affiliated with the following schools:
