Richard L. Jove

Q: What Schools Are Affiliated With Richard L. Jove

Richard L. Jove is affiliated with the following schools: Nova Southeastern University, University of Michigan, University of Southern California, University of South Florida, University of Puerto Rico, Lund University

Richard L. Jove's AcademicInfluence.com Rankings

Richard L. Jove

Philosophy

#4790

World Rank

#7436

Historical Rank

Logic

#2174

World Rank

#3109

Historical Rank

philosophy Degrees

Richard L. Jove

Biology

#6345

World Rank

#9037

Historical Rank

Immunology

#327

World Rank

#340

Historical Rank

Molecular Biology

#643

World Rank

#658

Historical Rank

biology Degrees

Download Badge

Philosophy
Biology

Why Is Richard L. Jove Influential?

(Suggest an Edit or Addition)

(See a Problem?)

Richard L. Jove's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

STATs in cancer inflammation and immunity: a leading role for STAT3 (2009) (3668)
The STATs of cancer — new molecular targets come of age (2004) (2266)
STATs in oncogenesis (2000) (1831)
Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells. (1999) (1730)
Revisiting STAT3 signalling in cancer: new and unexpected biological functions (2014) (1590)
Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis (2002) (1186)
Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells (2004) (1141)
Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention. (2002) (1097)
Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity (2005) (1019)
Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein. (1995) (982)
Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells (2001) (775)
Stat3 Activation by Src Induces Specific Gene Regulation and Is Required for Cell Transformation (1998) (720)
Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity (2007) (711)
STAT proteins: novel molecular targets for cancer drug discovery (2000) (654)
Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression. (2001) (632)
Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors. (2009) (611)
Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice. (2003) (605)
Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways (2005) (555)
Constitutive activation of Stat3 in human prostate tumors and cell lines: direct inhibition of Stat3 signaling induces apoptosis of prostate cancer cells. (2002) (537)
The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors. (2009) (534)
Persistent Activation of Stat3 Signaling Induces Survivin Gene Expression and Confers Resistance to Apoptosis in Human Breast Cancer Cells (2006) (516)
Activating SRC mutation in a subset of advanced human colon cancers (1999) (490)
Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis (2001) (488)
AKT1/PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells. (2001) (487)
Hyperactivation of STAT3 Is Involved in Abnormal Differentiation of Dendritic Cells in Cancer (2004) (475)
Phosphotyrosyl Peptides Block Stat3-mediated DNA Binding Activity, Gene Regulation, and Cell Transformation* (2001) (443)
Mechanisms of Disease: insights into the emerging role of signal transducers and activators of transcription in cancer (2005) (436)
Roles of activated Src and Stat3 signaling in melanoma tumor cell growth (2002) (426)
Constitutive activation of Stat3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells. (1997) (408)
A critical role for Stat3 signaling in immune tolerance. (2003) (404)
Stat3 regulates genes common to both wound healing and cancer (2005) (394)
Action of the Src family kinase inhibitor, dasatinib (BMS-354825), on human prostate cancer cells. (2005) (375)
Stat3-induced S1PR1 expression is critical for persistent Stat3 activation in tumors (2010) (370)
Activation of Stat3 by receptor tyrosine kinases and cytokines regulates survival in human non-small cell carcinoma cells (2003) (360)
Cell transformation by the viral src oncogene. (1987) (350)
Role of Stat3 in Regulating p53 Expression and Function (2005) (348)
In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses (2009) (347)
Gene therapy with dominant-negative Stat3 suppresses growth of the murine melanoma B16 tumor in vivo. (1999) (327)
JAK/STAT3-Regulated Fatty Acid β-Oxidation Is Critical for Breast Cancer Stem Cell Self-Renewal and Chemoresistance. (2018) (320)
Induction of p21WAF1/CIP1 and cyclin D1 expression by the Src oncoprotein in mouse fibroblasts: role of activated STAT3 signaling (2000) (309)
Histone deacetylase inhibitor LAQ824 both lowers expression and promotes proteasomal degradation of Bcr-Abl and induces apoptosis of imatinib mesylate-sensitive or -refractory chronic myelogenous leukemia-blast crisis cells. (2003) (308)
Raf exists in a native heterocomplex with hsp90 and p50 that can be reconstituted in a cell-free system. (1993) (307)
Indirubin derivatives inhibit Stat3 signaling and induce apoptosis in human cancer cells (2005) (295)
Targeting STAT3 affects melanoma on multiple fronts (2005) (281)
Requirement for Ras/Rac1-Mediated p38 and c-Jun N-Terminal Kinase Signaling in Stat3 Transcriptional Activity Induced by the Src Oncoprotein (1999) (276)
Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein (2006) (269)
Activation of Stat3 in Primary Tumors from High-Risk Breast Cancer Patients Is Associated with Elevated Levels of Activated Src and Survivin Expression (2006) (261)
JAK/STAT3-Regulated Fatty Acid β-Oxidation Is Critical for Breast Cancer Stem Cell Self-Renewal and Chemoresistance. (2018) (261)
Inhibition of pp60c-Src reduces Bcl-XL expression and reverses the transformed phenotype of cells overexpressing EGF and HER-2 receptors (1999) (253)
Novel peptidomimetic inhibitors of signal transducer and activator of transcription 3 dimerization and biological activity. (2004) (242)
S1PR1-STAT3 signaling is crucial for myeloid cell colonization at future metastatic sites. (2012) (239)
Dasatinib inhibits migration and invasion in diverse human sarcoma cell lines and induces apoptosis in bone sarcoma cells dependent on SRC kinase for survival. (2007) (236)
Activation of STAT transcription factors in oncogenic tyrosine kinase signaling. (1998) (235)
Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival. (2006) (209)
Acetylated STAT3 is crucial for methylation of tumor-suppressor gene promoters and inhibition by resveratrol results in demethylation (2012) (209)
The hsp90-binding Antibiotic Geldanamycin Decreases Raf Levels and Epidermal Growth Factor Signaling without Disrupting Formation of Signaling Complexes or Reducing the Specific Enzymatic Activity of Raf Kinase* (1997) (208)
Activation of c-Src by receptor tyrosine kinases in human colon cancer cells with high metastatic potential (1997) (206)
Role of epidermal growth factor receptor and STAT-3 activation in autonomous proliferation of SUM-102PT human breast cancer cells. (1997) (205)
Prediction of radiation sensitivity using a gene expression classifier. (2005) (204)
Inhibition of constitutive signal transducer and activator of transcription 3 activation by novel platinum complexes with potent antitumor activity. (2004) (199)
STAT5 activation by BCR-Abl contributes to transformation of K562 leukemia cells. (1999) (198)
Cooperative Regulation of Mcl-1 by Janus Kinase/STAT and Phosphatidylinositol 3-Kinase Contribute to Granulocyte-Macrophage Colony-Stimulating Factor-Delayed Apoptosis in Human Neutrophils1 (2001) (197)
miR‐194 is a marker of hepatic epithelial cells and suppresses metastasis of liver cancer cells in mice (2010) (196)
Requirement of Stat3 signaling for HGF/SF-Met mediated tumorigenesis (2002) (195)
Beta1 integrin adhesion enhances IL-6-mediated STAT3 signaling in myeloma cells: implications for microenvironment influence on tumor survival and proliferation. (2009) (180)
STAT proteins as novel targets for cancer therapy. Signal transducer an activator of transcription. (1999) (180)
Roles of Gab1 and SHP2 in Paxillin Tyrosine Dephosphorylation and Src Activation in Response to Epidermal Growth Factor* (2004) (175)
Loss of androgen receptor expression promotes a stem-like cell phenotype in prostate cancer through STAT3 signaling. (2014) (175)
Activation of Stat3 in v-Src-transformed Fibroblasts Requires Cooperation of Jak1 Kinase Activity* (2000) (175)
An oxazole-based small-molecule Stat3 inhibitor modulates Stat3 stability and processing and induces antitumor cell effects. (2007) (173)
MicroRNA-26a regulates insulin sensitivity and metabolism of glucose and lipids. (2015) (170)
Signal Transducer and Activator of Transcription 3 Is Required for Hypoxia-Inducible Factor-1α RNA Expression in Both Tumor Cells and Tumor-Associated Myeloid Cells (2008) (167)
The pyrido[2,3-d]pyrimidine derivative PD180970 inhibits p210Bcr-Abl tyrosine kinase and induces apoptosis of K562 leukemic cells. (2000) (166)
Activation of Phosphatidylinositol 3-Kinase/Akt Pathway by Androgen through Interaction of p85α, Androgen Receptor, and Src* (2003) (161)
Cytoplasmic transport of Stat3 by receptor‐mediated endocytosis (2002) (159)
SKI-606 (bosutinib), a novel Src kinase inhibitor, suppresses migration and invasion of human breast cancer cells (2008) (154)
Inhibition of Bcr–Abl kinase activity by PD180970 blocks constitutive activation of Stat5 and growth of CML cells (2002) (152)
Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity (2008) (152)
Role of Tyrosine Kinase Activity of Epidermal Growth Factor Receptor in the Lysophosphatidic Acid-stimulated Mitogen-activated Protein Kinase Pathway* (1998) (150)
Novel angiogenesis inhibitory activity in cinnamon extract blocks VEGFR2 kinase and downstream signaling. (2010) (149)
Overexpression of a dominant-negative signal transducer and activator of transcription 3 variant in tumor cells leads to production of soluble factors that induce apoptosis and cell cycle arrest. (2001) (138)
Neurofibromatosis type 1 gene product (neurofibromin) associates with microtubules (1993) (137)
Expression and role of Foxa proteins in prostate cancer (2006) (134)
AKT2, a member of the protein kinase B family, is activated by growth factors, v-Ha-ras, and v-src through phosphatidylinositol 3-kinase in human ovarian epithelial cancer cells. (1998) (134)
The novel histone deacetylase inhibitor, LBH589, induces expression of DNA damage response genes and apoptosis in Ph- acute lymphoblastic leukemia cells. (2007) (132)
A Novel Platinum Compound Inhibits Constitutive Stat3 Signaling and Induces Cell Cycle Arrest and Apoptosis of Malignant Cells* (2005) (131)
Sorafenib Induces Growth Arrest and Apoptosis of Human Glioblastoma Cells through the Dephosphorylation of Signal Transducers and Activators of Transcription 3 (2010) (124)
The novel JAK inhibitor AZD1480 blocks STAT3 and FGFR3 signaling, resulting in suppression of human myeloma cell growth and survival (2011) (119)
Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity (2005) (119)
Molecular characterization and sensitivity of STI-571 (imatinib mesylate, Gleevec)-resistant, Bcr-Abl-positive, human acute leukemia cells to SRC kinase inhibitor PD180970 and 17-allylamino-17-demethoxygeldanamycin. (2002) (118)
Critical role of STAT3 in IL-6-mediated drug resistance in human neuroblastoma. (2013) (118)
Activation of Stat3 preassembled with platelet-derived growth factor β receptors requires Src kinase activity (2000) (117)
Inhibition of Src Family Kinases with Dasatinib Blocks Migration and Invasion of Human Melanoma Cells (2008) (116)
Cell-to-cell adhesion modulates Stat3 activity in normal and breast carcinoma cells (2004) (116)
Antiangiogenic and antimetastatic activity of JAK inhibitor AZD1480. (2011) (113)
CD5 Binds to Interleukin-6 and Induces a Feed-Forward Loop with the Transcription Factor STAT3 in B Cells to Promote Cancer. (2016) (113)
Constitutive activation of the Janus kinase-STAT pathway in T lymphoma overexpressing the Lck protein tyrosine kinase. (1997) (111)
Flavopiridol down-regulates antiapoptotic proteins and sensitizes human breast cancer cells to epothilone B-induced apoptosis. (2003) (109)
Regulation of adipose tissue T cell subsets by Stat3 is crucial for diet-induced obesity and insulin resistance (2013) (106)
Effects of dasatinib on SRC kinase activity and downstream intracellular signaling in primitive chronic myelogenous leukemia hematopoietic cells. (2008) (105)
Activation of STAT transcription factors by herpesvirus Saimiri Tip-484 requires p56lck (1997) (105)
Dasatinib (BMS-354825) inhibits Stat5 signaling associated with apoptosis in chronic myelogenous leukemia cells (2007) (104)
STAT3 inhibition is a therapeutic strategy for ABC-like diffuse large B-cell lymphoma. (2011) (102)
miR-26a enhances miRNA biogenesis by targeting Lin28B and Zcchc11 to suppress tumor growth and metastasis (2014) (101)
6-Bromoindirubin-3'-oxime inhibits JAK/STAT3 signaling and induces apoptosis of human melanoma cells. (2011) (98)
Combining histone deacetylase inhibitor vorinostat with aurora kinase inhibitors enhances lymphoma cell killing with repression of c-Myc, hTERT, and microRNA levels. (2011) (97)
COHCAP: an integrative genomic pipeline for single-nucleotide resolution DNA methylation analysis (2013) (95)
Sorafenib inhibits signal transducer and activator of transcription 3 signaling associated with growth arrest and apoptosis of medulloblastomas (2008) (94)
The high-mobility group A1a/signal transducer and activator of transcription-3 axis: an achilles heel for hematopoietic malignancies? (2008) (93)
Role of altered growth factor receptor-mediated JAK2 signaling in growth and maintenance of human acute myeloid leukemia stem cells. (2014) (92)
Identification of Src transformation fingerprint in human colon cancer (2002) (92)
Constitutive Activation of Stat 3 in Human Prostate Tumors and Cell Lines : Direct Inhibition of Stat 3 Signaling Induces Apoptosis of Prostate Cancer Cells 1 (2002) (91)
A Direct Interaction between G-Protein βγ Subunits and the Raf-1 Protein Kinase (*) (1995) (88)
Activation of STAT3 by the c-Fes Protein-tyrosine Kinase* (1998) (86)
Enzymatically inactive p60c-src mutant with altered ATP-binding site is fully phosphorylated in its carboxy-terminal regulatory region (1987) (85)
Reconstitution of the multiprotein complex of pp60src, hsp90, and p50 in a cell-free system. (1992) (82)
Role of the cytoplasmic tyrosines of β1A integrins in transformation by v-src (2001) (80)
Dual inhibition of Janus and Src family kinases by novel indirubin derivative blocks constitutively‐activated Stat3 signaling associated with apoptosis of human pancreatic cancer cells (2013) (75)
Novel synthetic derivatives of the natural product berbamine inhibit Jak2/Stat3 signaling and induce apoptosis of human melanoma cells (2012) (75)
Erratum: JAK/STAT3-Regulated Fatty Acid β-Oxidation Is Critical for Breast Cancer Stem Cell Self-Renewal and Chemoresistance (Cell Metabolism (2018) 27(1) (136–150.e5)(S1550413117306691)(10.1016/j.cmet.2017.11.001)) (2018) (74)
The Ras GTPase-activating Protein (GAP) Is an SH3 Domain-binding Protein and Substrate for the Src-related Tyrosine Kinase, Hck (*) (1995) (73)
Constitutive activation of the JAK2/STAT5 signal transduction pathway correlates with growth factor independence of megakaryocytic leukemic cell lines. (1999) (72)
Indirubin derivatives induce apoptosis of chronic myelogenous leukemia cells involving inhibition of Stat5 signaling (2012) (71)
General approach for preparing epidithiodioxopiperazines from trioxopiperazine precursors: enantioselective total syntheses of (+)- and (-)-gliocladine C, (+)-leptosin D, (+)-T988C, (+)-bionectin A, and (+)-gliocladin A. (2013) (70)
Splicing pathways of SV40 mRNAs in X. laevis oocytes differ in their requirements for snRNPs (1984) (69)
Synergistic anti-tumor effect of combined inhibition of EGFR and JAK/STAT3 pathways in human ovarian cancer (2015) (69)
Characterization of avian and viral p60src proteins expressed in yeast. (1987) (68)
Modification of insulin-like growth factor 1 receptor, c-Src, and Bcl-XL protein expression during the progression of Barrett's neoplasia. (2003) (66)
Targeting JAK1/STAT3 Signaling Suppresses Tumor Progression and Metastasis in a Peritoneal Model of Human Ovarian Cancer (2014) (63)
Two SH2 Domains of p120 Ras GTPase-activating Protein Bind Synergistically to Tyrosine Phosphorylated p190 Rho GTPase-activating Protein (*) (1995) (62)
A Novel Berbamine Derivative Inhibits Cell Viability and Induces Apoptosis in Cancer Stem-Like Cells of Human Glioblastoma, via Up-Regulation of miRNA-4284 and JNK/AP-1 Signaling (2014) (61)
In vitro transcription from the adenovirus 2 major late promoter utilizing templates truncated at promoter-proximal sites. (1984) (61)
Activated stat-3 in melanoma. (2008) (61)
Stat3 is required for full neoplastic transformation by the Simian Virus 40 large tumor antigen. (2005) (59)
Multiple Myeloma: New Insights and Therapeutic Approaches. (2000) (59)
Antitumor Activity of Targeting Src Kinases in Endothelial and Myeloid Cell Compartments of the Tumor Microenvironment (2010) (58)
Preface: STAT signaling (2000) (58)
miR-302b maintains "stemness" of human embryonal carcinoma cells by post-transcriptional regulation of Cyclin D2 expression. (2008) (58)
Elevated c-Src protein expression is an early event in colonic neoplasia. (1998) (58)
Src activation in melanoma and Src inhibitors as therapeutic agents in melanoma (2009) (57)
Isoform selective inhibition of STAT1 or STAT3 homo-dimerization via peptidomimetic probes: structural recognition of STAT SH2 domains. (2007) (56)
Combination therapy with AG-490 and interleukin 12 achieves greater antitumor effects than either agent alone. (2002) (56)
TLR9 is critical for glioma stem cell maintenance and targeting. (2014) (56)
Interleukin-3 protects Bcr-Abl-transformed hematopoietic progenitor cells from apoptosis induced by Bcr-Abl tyrosine kinase inhibitors (2002) (55)
Spontaneous activation and signaling by overexpressed epidermal growth factor receptors in glioblastoma cells (2003) (55)
Src family kinases promote AML cell survival through activation of signal transducers and activators of transcription (STAT). (2008) (53)
GTPase-activating protein interactions with the viral and cellular Src kinases. (1991) (53)
Alkylation of cysteine 468 in Stat3 defines a novel site for therapeutic development. (2011) (53)
Dissociation of Mitogen-activated Protein Kinase Activation from the Oxidative Burst in Differentiated HL-60 Cells and Human Neutrophils (*) (1995) (53)
Raf-1 N-terminal sequences necessary for Ras-Raf interaction and signal transduction (1995) (52)
SIRT1 activation enhances HDAC inhibition-mediated upregulation of GADD45G by repressing the binding of NF-κB/STAT3 complex to its promoter in malignant lymphoid cells (2013) (51)
Regulation of the Cyclin D3 Promoter by E2F1* (2003) (50)
Role of the cytoplasmic tyrosines of beta 1A integrins in transformation by v-src. (2001) (50)
Inhibition of JAK kinase activity enhances Fas-mediated apoptosis but reduces cytotoxic activity of topoisomerase II inhibitors in U266 myeloma cells. (2001) (49)
Roscovitine inhibits STAT5 activity and induces apoptosis in the human leukemia virus type 1-transformed cell line MT-2. (2003) (49)
Drug resistance in multiple myeloma: approaches to circumvention. (1999) (48)
Genetic lesions involved in temperature sensitivity of the src gene products of four Rous sarcoma virus mutants (1986) (47)
Molecular Cloning and Characterization of the Human AKT1 Promoter Uncovers Its Up-regulation by the Src/Stat3 Pathway* (2005) (47)
Genetic analysis of p60v-src domains involved in the induction of different cell transformation parameters (1986) (47)
The native v-Raf.hsp90.p50 heterocomplex contains a novel immunophilin of the FK506 binding class. (1994) (46)
Activated Signal Transducers and Activators of Transcription 3 Signaling Induces CD46 Expression and Protects Human Cancer Cells from Complement-Dependent Cytotoxicity (2007) (46)
G-protein-coupled Receptor Agonist BV8/Prokineticin-2 and STAT3 Protein Form a Feed-forward Loop in Both Normal and Malignant Myeloid Cells* (2013) (46)
Overexpression of normal c-Src in poorly metastatic human colon cancer cells enhances primary tumor growth but not metastatic potential. (1997) (46)
Biochemical properties of p60v-src mutants that induce different cell transformation parameters (1986) (45)
The protein-protein complex between pp60v-src and hsp90 is stabilized by molybdate, vanadate, tungstate, and an endogenous cytosolic metal. (1992) (44)
The membrane-binding domain and myristylation of p60v-src are not essential for stimulation of cell proliferation (1987) (44)
Human topoisomerase IIα nuclear export is mediated by two CRM-1-dependent nuclear export signals (2004) (42)
Bioactive Cycloperoxides Isolated from the Puerto Rican Sponge Plakortis halichondrioides. (2010) (40)
Attenuation of serum inducibility of immediate early genes by oncoproteins in tyrosine kinase signaling pathways (1993) (39)
Molecular features of the viral and cellular Src kinases involved in interactions with the GTPase-activating protein (1991) (37)
Regulation of the junB gene by v-src (1992) (35)
The Src-family kinase Lck can induce STAT3 phosphorylation and DNA binding activity. (1999) (34)
Transcription initiation by RNA polymerase II is inhibited by S-adenosylhomocysteine. (1982) (34)
Cytotoxic prenylated acetophenone dimers from Acronychia pedunculata. (2012) (33)
Humanized Lewis-Y specific antibody based delivery of STAT3 siRNA. (2011) (33)
STAT3 Activation by Type I Interferons Is Dependent on Specific Tyrosines Located in the Cytoplasmic Domain of Interferon Receptor Chain 2c (2002) (33)
Activated STAT3 as a correlate of distant metastasis in prostate cancer: a secondary analysis of Radiation Therapy Oncology Group 86-10. (2007) (33)
Differences and similarities between cancer and somatic stem cells: therapeutic implications (2020) (33)
Differential effects of Stat3 inhibition in sparse vs confluent normal and breast cancer cells. (2006) (32)
A novel 7-bromoindirubin with potent anticancer activity suppresses survival of human melanoma cells associated with inhibition of STAT3 and Akt signaling (2012) (30)
Expression, purification and characterization of recombinant mitogen-activated protein kinase kinases. (1994) (29)
Activation of extracellular signal-regulated kinase (ERK) by mitogenic stimuli is repressed in v-Src-transformed cells. (1997) (29)
MLS-2384, a new 6-bromoindirubin derivative with dual JAK/Src kinase inhibitory activity, suppresses growth of diverse cancer cells (2014) (29)
Molecular dynamics simulations of the conformational changes in signal transducers and activators of transcription, Stat1 and Stat3. (2009) (29)
Bortezomib induces apoptosis and growth suppression in human medulloblastoma cells, associated with inhibition of AKT and NF-ĸB signaling, and synergizes with an ERK inhibitor. (2012) (28)
Activation of phosphatidylinositol 3-kinase/Akt pathway by androgen through interaction of p85α, androgen receptor, and Src. (2016) (28)
A simple method to improve probe set estimates from oligonucleotide arrays. (2002) (28)
TLR agonist–Stat3 siRNA conjugates: cell-specific gene silencing and enhanced antitumor immune responses (2009) (27)
Spirooxindole Derivative SOID-8 Induces Apoptosis Associated with Inhibition of JAK2/STAT3 Signaling in Melanoma Cells (2012) (27)
A novel synthetic derivative of the natural product berbamine inhibits cell viability and induces apoptosis of human osteosarcoma cells, associated with activation of JNK/AP-1 signaling (2013) (26)
Lack of induction of neuroretinal cell proliferation by Rous sarcoma virus variants that carry the c-src gene (1985) (25)
Activated Src tyrosine kinase phosphorylates Tyr-457 of bovine GTPase-activating protein (GAP) in vitro and the corresponding residue of rat GAP in vivo. (1992) (25)
Sorafenib inhibits endogenous and IL-6/S1P induced JAK2-STAT3 signaling in human neuroblastoma, associated with growth suppression and apoptosis (2012) (25)
STAT 5 Activation by BCR-Abl Contributes to Transformation of K 562 Leukemia Cells (1999) (24)
Immunotherapy as part of a multidisciplinary approach to melanoma treatment. (2006) (24)
Upregulation of Fanconi Anemia DNA Repair Genes in Melanoma Compared to Non-Melanoma Skin Cancer (2011) (24)
Transcription of methylated eukaryotic viral genes in a soluble in vitro system. (1984) (22)
Inhibition of STAT3 activity with STAT3 antisense oligonucleotide (STAT3-ASO) enhances radiation-induced apoptosis in DU145 prostate cancer cells (2003) (20)
Synthesis and anticancer activities of ageladine A and structural analogs. (2010) (20)
Reconstitution of interactions between the Src tyrosine kinases and Ras GTPase-activating protein using a baculovirus expression system. (1992) (20)
Tyrosine phosphorylation of Ras GTPase-activating protein stabilizes its association with p62 at membranes of v-Src transformed cells. (1993) (20)
MEKK1-induced apoptosis requires TRAIL death receptor activation and is inhibited by AKT/PKB through inhibition of MEKK1 cleavage (2002) (19)
Ruxolitinib synergistically enhances the anti-tumor activity of paclitaxel in human ovarian cancer (2018) (19)
Amphidinolide B: total synthesis, structural investigation, and biological evaluation. (2013) (18)
Localization of the viral and cellular Src kinases to perinuclear vesicles in fibroblasts. (1992) (18)
Necdin, a Negative Growth Regulator, Is a Novel STAT3 Target Gene Down-Regulated in Human Cancer (2011) (18)
In vivo phosphorylation states and kinase activities of transforming p60c-src mutants. (1989) (16)
1,3-Bis(3,5-dichlorophenyl) urea compound 'COH-SR4' inhibits proliferation and activates apoptosis in melanoma. (2012) (15)
RbAp48 regulates cytoskeletal organization and morphology by increasing K-Ras activity and signaling through mitogen-activated protein kinase. (2007) (15)
Stat3 activity is required for gap junctional permeability in normal rat liver epithelial cells. (2009) (15)
Analysis of p60v-src mutants carrying lesions involved in temperature sensitivity (1987) (13)
Activated Stat3 in Melanoma (2008) (13)
miR-302 b maintains “ stemness ” of human embryonal carcinoma cells by post-transcriptional regulation of Cyclin D 2 expression (2008) (13)
Carboxy-terminal truncated STAT5 is induced by interleukin-2 and GM-CSF in human neutrophils. (2002) (12)
Differential regulation of neurofibromin and p120 GTPase-activating protein by nutritionally relevant fatty acids. (1998) (12)
N-terminal Sequences Contained in the Src Homology 2 and 3 Domains of p120 GTPase-activating Protein Are Required for Full Catalytic Activity Toward Ras (*) (1996) (12)
AG490 inhibits G1-S traverse in BALB/c-3T3 cells following either mitogenic stimulation or exogenous expression of E2F-1. (2004) (11)
Prognostic Significance of Neutrophilic Infiltration in Benign Lymph Nodes in Patients with Muscle-invasive Bladder Cancer. (2017) (10)
Prostate adenocarcinoma: cellular and molecular abnormalities. (2001) (10)
Natural-Based Indirubins Display Potent Cytotoxicity toward Wild-Type and T315I-Resistant Leukemia Cell Lines. (2016) (10)
3-O-methylthespesilactam, a new small-molecule anticancer pan-JAK inhibitor against A2058 human melanoma cells. (2013) (9)
Abstract 981: SRT1 activation enhances HDAC inhibition-mediated upregulation of GADD45G by repressing the binding of NF-kB/STAT3 complex to its promoter in malignant lymphoid cells (2012) (9)
In situ electroporation of large numbers of cells using minimal volumes of material. (2003) (9)
Constitutive Activation of the JAK 2 / STAT 5 Signal Transduction Pathway Correlates With Growth Factor Independence of Megakaryocytic Leukemic Cell Lines (1999) (9)
The discovery of new cytotoxic pyrazolopyridine derivatives. (2016) (9)
RNA polymerase II terminates transcription in vitro in the SV40 origin region. (1987) (9)
Increasing Antitumor Activity of JAK Inhibitor by Simultaneous Blocking Multiple Survival Signaling Pathways in Human Ovarian Cancer (2019) (7)
STAT 3 Inhibition Is a Therapeutic Strategy for ABC-like Diffuse Large B-Cell Lymphoma (2011) (7)
Synergistic Anti-Tumor Activity by Targeting Multiple Signaling Pathways in Ovarian Cancer (2020) (7)
Signal Transduction Proteins in Tumors From Puerto Rican and Caucasian Gastric Adenocarcinoma Patients: Expression Differences With Potential for Specific Targeted Therapies (2008) (6)
Synthesis and antiproliferative activity of new pyrazolo[3,4-c]pyridines. (2017) (6)
STAT Proteins as Molecular Targets for Cancer Therapy (2003) (6)
Advances in Brief Gene Therapy with Dominant-negative Stat 3 Suppresses Growth of the Murine Melanoma B 16 Tumor in Vivo 1 (1999) (5)
Proximal promoter region of the junB gene mediates attenuation of serum inducibility in Src-transformed cells. (1995) (5)
Molecular cloning and characterization of the human AKT1 promoter uncovers its up-regulation by the Src/Stat3 pathway. (2016) (5)
Corrigendum: Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells (2004) (5)
Synthesis and in vitro biological evaluation of novel pyrazole derivatives as potential antitumor agents. (2012) (5)
Targeting JAK 1 / STAT 3 signaling suppresses tumor progression and metastasis in a peritoneal model of human ovarian cancer (2014) (5)
Preliminary pharmacokinetic study of the anticancer 6BIO in mice using an UHPLC‐MS/MS approach (2019) (4)
Activation of STAT Transcription Factors in Oncogenic Tyrosine Kinase Signaling (1998) (4)
COHCAP: an integrative genomic pipeline for single-nucleotide resolution DNA methylation analysis (2019) (4)
Molecular Features oftheViral andCellular SrcKinases Involved inInteractions withtheGTPase-Activating Protein (1991) (4)
Expression of STAT proteins and interferon receptors in benign and malignant melanocytic lesions: Correlation with recurrence. (2004) (4)
Convection-enhanced delivery of sorafenib and suppression of tumor progression in a murine model of brain melanoma through the inhibition of signal transducer and activator of transcription 3. (2016) (4)
The effect of the PI3K/AKT pathway inhibition on leiomyosarcoma cells. (2004) (4)
Expression of STAT proteins and interferon receptors in benign and malignant melanocytic lesions: Correlation with recurrence (2004) (3)
STAT3 nuclear egress requires exportin 7 via engaging lysine acetylation (2014) (3)
Targeting Src/Stat3 pathway in malignant melanoma. (2006) (3)
Dasatinib (BMS-354825), a novel multi-targeted kinase inhibitor that blocks tumor cell migration and invasion, is a promising therapeutic agent for metastatic prostate cancer (2006) (3)
The HMGA1a-STAT3 axis: an “Achilles Heel” for Hematopoietic Malignancies Overexpressing HMGA1a? (2008) (3)
Discovery of a novel abl tyrosine kinase inhibitor that selectively induces apoptosis of bcr-abl-positive leukemic cells (2000) (3)
1 Loss of Androgen Receptor Expression Promotes a Stem-Like Cell Phenotype in Prostate Cancer through STAT 3 Signaling (2013) (2)
A randomized phase II neoadjuvant trial in patients with stages II-III and inflammatory breast cancer. (2007) (2)
cells sensitive and resistant to STI-571 in association with down-regulation of Bcr- Abl, abrogation of STAT5 activity, and Bax conformational change. (2004) (2)
Combination Therapy with the Histone Deacetylase Inhibitor Vorinostat Plus the Novel Aurora Kinase A Inhibitor MK-5108 Leads to Enhanced Lymphoma Cell Death Due to Acetylation of p53 and Repression of c-Myc, hTERT, and miRNA Levels. (2009) (2)
The Src family kinase inhibitor, dasatinib, inhibits angiogenesis in vitro and in vivo (2008) (2)
Roscovitine Inhibits STAT 5 Activity and Induces Apoptosis in the Human Leukemia Virus Type 1-Transformed Cell Line MT2 (2003) (2)
Prediction of Radiation Sensitivity Using a Gene (2005) (2)
Induction of apoptosis in large granular lymphocyte (Lgl) Leukemia by jak tyrosine kinase inhibitor AG-490: Role of STAT3-regulated MCL-1 (2000) (2)
An oxazole-based small-molecule stat3 inhibitor modulates stat3 stability and processing and induces antitumor cell effects (ACS Chemical Biology (2007) 2, (787-798)) (2009) (2)
Effect of dasatinib, a SRC kinase inhibitor, on lung cancer cells with defined epidermal growth factor receptor status. (2006) (1)
Combination of the Histone Deacetylase Inhibitor Vorinostat and Dasatinib Increases Apoptosis in Bcr-abl+ Cells and Reverses Changes Associated with CML Progression. (2006) (1)
The effect of the proteosome inhibitor, PS 341 on leiomyosarcoma cells (2005) (1)
Leukemia-Blast Crisis Cells Mesylate-sensitive or-refractory Chronic Myelogenous Bcr-Abl and Induces Apoptosis of Imatinib Expression and Promotes Proteasomal Degradation of Histone Deacetylase Inhibitor LAQ 824 Both Lowers (2003) (1)
Defining a molecular fingerprint of STAT3-regulated genes associated with oncogenesis using microarray technology and novel statistical methods (2001) (1)
Historical Development of STAT3 Inhibitors and Early Results in Clinical Trials (2016) (1)
Novel Stat3-regulated genes in prostate cancer identified by microarray analysis. (2004) (1)
Disruption of STAT3 Signaling in Antigen Presenting Cells Represents a Novel Strategy To Overcome Tumor-Induced Antigen-Specific CD4+ T-Cell Tolerance. (2004) (1)
AG 490 inhibits G 1S traverse in BALB / c-3 T 3 cells following either mitogenic stimulation or exogenous expression of E 2 F-1 (2004) (1)
Indirubin derivatives inhibit SFKs/Stat signaling associated with apoptosis in human cancer cells (2008) (1)
Versatile selective kinase inhibitors: Chemistry and biology of indirubins (2012) (1)
"US-JAPAN CONFERENCE: INFLAMMATION, DIABETES AND CANCER" held at the Beckman Research Institute of City of Hope, Duarte, CA, USA. (2011) (1)
Oxidative Stress Induces Binding of FANCD2 to STAT5 and Facilitates STAT5-Dependent Survival Signals. (2004) (1)
STAT3: A Direct HMGA1 Gene Target Important in Lymphoid Malignancy. (2006) (1)
CPA7, a Novel Stat3 Inhibitor Radiosensitizes Prostate Cancer Cells (2005) (1)
INTERLEUKIN-12 Enhances the antitumor effect of the tyrosine kinase inhibitor AG-490 in a murine myeloma model (2000) (1)
An oxazole-based small-molecule Stat3 inhibitor induces Stat3 aggresome formation and antitumor cell effects (2008) (1)
Abstract 2069: A novel berbamine derivative induces apoptosis of chemotherapy-resistant human osteosarcoma cells through activation of ROS/JNK signaling (2012) (1)
Sorafenib inhibits endogenous and IL-6/S1P induced JAK2-STAT3 signaling in human neuroblastoma, associated with growth suppression and apoptosis (2012) (1)
The Src family kinase inhibitor dasatinib (BMS-354825) blocks migration and invasion of human melanoma cells (2007) (1)
Use of the Rat Gene Index to examine gene expression patterns from Src-transformed rat fibroblasts that exhibit broad differences in metastatic potential (1999) (1)
SKI-606, a novel Src kinase inhibitor, blocks migration and invasion of human breast cancer cells (2007) (1)
A novel lipase belonging to the hormone-sensitive lipase family induced under starvation to utilize stored triacylglycerol in Mycobacterium tuberculosis (2020) (1)
Apoptosis in Human Neutrophils Colony-Stimulating Factor-Delayed Granulocyte-Macrophage 3-Kinase Contribute to Kinase/STAT and Phosphatidylinositol Cooperative Regulation of Mcl-1 by Janus (2001) (1)
Therapeutic potential of ruxolitinib in human ovarian cancer (2016) (1)
JAK/STAT Signaling in Myeloid Cells (2013) (0)
Combination Therapy with Histone Deacetylase Inhibitor Vorinostat Plus Aurora Kinase Inhibitor MK-0457 Leads to Enhanced Lymphoma Cell Killing with Stabilization of p53 and Repression of C-Myc, hTERT, and Myc-Responsive miRNAs (2008) (0)
Abstract 4340: Sorafenib induces growth arrest and apoptosis in neuroblastoma cells via inhibition of JAK2/STAT3 and MEK1/2/MAPK (p44/42) signaling pathways (2011) (0)
Abstract SY06-02: Revisiting the STATs of cancer: Emergence of stem-like cancer cells (2014) (0)
Protein expression of MMP2, TIMP2 in hepatocellular carcinoma: relationships with tumor grade, clinicopathologic parameters, and patient survival. (2006) (0)
Extent of neutrophil (NTP) infiltration in benign lymph nodes (LNs) to predict survival in patients with muscle-invasive bladder cancer (MIBC). (2013) (0)
leukemia cells DNA damage response genes and apoptosis in Ph- acute lymphoblastic The novel histone deacetylase inhibitor, LBH589, induces expression of (2013) (0)
Abstract 2576: Mechanism of action of a novel Stat3 inhibitor for cancer therapy (2011) (0)
Novel pathway of Rac1 and Stat3 interaction (2006) (0)
Chapter 26 – JAK/STAT Signaling in Myeloid Cells: Targets for Cancer Immunotherapy (2013) (0)
Advances in Brief Overexpression of a Dominant-Negative Signal Transducer and Activator of Transcription 3 Variant in Tumor Cells Leads to Production of Soluble Factors That Induce Apoptosis and Cell Cycle Arrest 1 (2001) (0)
Abstract 1636: NMR discovery and molecular-basis of small molecule inhibitors of STAT3 (2014) (0)
Prediction of survival in patients with muscle-invasive bladder cancer (MIBC) by neutrophil (NTP) infiltration in benign lymph nodes (LNs). (2013) (0)
Signal Transducers and Activators of Transcription in Oncogenesis (2015) (0)
STAT3 inhibitor having anti-cancer activity and methods (US) (2020) (0)
Abstract 5518: A novel 1,3-bis(3,5-dichlorophenyl) urea compound ‘COH-SR4’ for targeting melanoma. (2013) (0)
STAT3 Silencing as a Novel Therapeutic Strategy for Activated B Cell-Type Diffuse Large B-Cell Lymphoma. (2009) (0)
O-134 Patterns of STAT expression in non-small cell lung cancer (2003) (0)
547 POSTER Novei small-molecule inhibitors of STAT3 that selectively induce antitumor cell activity (2006) (0)
Inhibition of neurofibromin and p120 GTPase activating protein (GAP) by dietary fatty acids. (1999) (0)
Microenvironment and Immunology Antiangiogenic and Antimetastatic Activity of JAK Inhibitor AZD 1480 (2011) (0)
A novel pathway of Stat3 interaction with the Rho GTPases (2007) (0)
Author and Subject Index (1998) (0)
in Cancer Abnormal Differentiation of Dendritic Cells Hyperactivation of STAT3 Is Involved in (2003) (0)
PL-11 Diverse roles of STAT3 signaling in cancer (2008) (0)
Abstract 5432: Spirooxindole derivative (SOID-8) inhibits proliferation and induces apoptosis by blocking JAK2/STAT3 signaling in melanoma cells (2011) (0)
Novel berbamine derivatives block Jak2/Stat3 signaling, associated with induction of apoptosis on human melanoma cells (2012) (0)
Differences and similarities between cancer and somatic stem cells: therapeutic implications (2020) (0)
Abstract 4845: Reeducate the tumor microenvironment to improve the anticancer efficacy of adoptive T-cell therapy (2012) (0)
Regenerative Medicine in the State of Florida: Letter Outlining the Florida Organization for Regenerative Medicine (2018) (0)
Abstract 4231: A 3′-substituted 7-bromoindirubin induces apoptosis of human melanoma cells via inhibition of STAT3 and AKT signaling (2011) (0)
Effect of dasatinib on BCR-ABL and Src mediated growth signaling in primary CML hematopoietic progenitors (2007) (0)
Regulates Cytoskeletal Organization and Morphology by Increasing KRas Activity and Signaling through Mitogen-Activated Protein Kinase (2007) (0)
Novel HDAC inhibitor, LBH589, potently blocks growth of Ph-negative acute lymphoblastic leukemia (ALL) cells and induces expression of DNA damage response genes (2007) (0)
The international translational regenerative medicine center. (2012) (0)
Tumor and Stem Cell Biology LossofAndrogenReceptorExpressionPromotesaStem-like Cell Phenotype in Prostate Cancer through STAT 3 Signaling (2014) (0)
Abstract 538: Targeting the tumor premetastatic microenvironment to prevent and inhibit cancer metastasis (2011) (0)
β1 Integrin Activation Via FN Adhesion Enhances IL-6 Response in Myeloma Cells. (2004) (0)
Abstract 2525: Modulation of src and STAT3 pathways with dasatinib in patients with metastatic pancreatic cancer (2010) (0)
B 1 Integrin Adhesion Enhances IL-6–Mediated STAT3 Signaling in Myeloma Cells: Implications for Microenvironment Influence on Tumor Survival and Proliferation (2009) (0)
Therapeutics , Targets , and Chemical Biology 6-Bromoindirubin-3 0-Oxime Inhibits JAK / STAT 3 Signaling and Induces Apoptosis of Human Melanoma Cells (2011) (0)
Cancer Biology and Signal Transduction Targeting JAK 1 / STAT 3 Signaling Suppresses Tumor Progression and Metastasis in a Peritoneal Model of Human Ovarian Cancer (2014) (0)
Synthesis and Anticancer Activities of Ageladine A and Structural Analogues. (2010) (0)
Abstract 1637: STAT3 as a new molecular target for treating ABC-like DLBCL (2011) (0)
72 Targeting JAK-STAT Signaling for Cancer Therapy (2012) (0)
Abstract 864: Novel synthetic berbamine derivatives inhibit Jak2/Stat3 signaling and induce apoptosis of human melanoma cells (2012) (0)
Corrigendum to “Isoform selective inhibition of STAT1 or STAT3 homo-dimerization via peptidomimetic probes: Structural recognition of STAT SH2 domains” [Bioorg. Med. Chem. Lett. 17 (2007) 1875–1878] (2007) (0)
Stat3 as a correlate of distant metastasis in RTOG 86–10 (2005) (0)
STAT3: An HMGA1 gene target involved in HMGA1-mediated leukemogenesis and possible therapeutic target (2007) (0)
Molecular Oncology: STAT signaling as a molecular target for cancer therapy (2013) (0)
growth and maintenance of human acute myeloid leukemia stem cells Role of altered growth factor receptor-mediated JAK2 signaling in (2014) (0)
Synergistic anti-tumor effect of combined inhibition of EGFR and JAK/STAT3 pathways in human ovarian cancer (2015) (0)
Role of aberrant stat signaling in blood malignancies (2000) (0)
Abstract 764: 6-Bromoindirubin-3′-oxime induces apoptosis of human melanoma cells associated with inhibition of JAK/STAT3 signaling (2010) (0)
Therapeutics , Targets , and Chemical Biology TLR 9 Is Critical for Glioma Stem Cell Maintenance and Targeting (2014) (0)
A method for inhibiting the proliferation of tumor cells, be used in the platinum complex (2004) (0)
Tumor and Stem Cell Biology LossofAndrogenReceptorExpressionPromotesaStem-like Cell Phenotype in Prostate Cancer through STAT3 Signaling (2014) (0)
NF2 protein expressions (1997) (0)
Abstract 508: Signal transduction and activator of transcription (STAT) 3 is necessary for environment-mediated drug resistance (2011) (0)
Novel SIRT1 Agonists, SRT501 and SRT2183, Induce Expression of DNA Repair Genes and Apoptosis of Ph− Acute Lymphoblastic Leukemia Cells Alone and in Combination with the HDAC Inhibitor LBH589.. (2009) (0)
Quantitative study of two indirubin derivatives: 6-Bromoindirubin-3′-oxime (6BIO) and 6-Bromoindirubin-3′-[O-(2-piperazine-1-ylethyl) oxime] (6BIO-pip) in mice plasma by LC-MS/MS. Application in a pharmacokinetic study (2014) (0)
Overview of the NSU Cell Therapy Institute (2016) (0)
Abstract 4345: Proteasome inhibitor, bortezomib, inhibits cell proliferation and induces apoptosis of medulloblastoma cells (2010) (0)
Constitutive activation of stat signaling in myeloid leukemia cells is associated with resistance to apoptosis (2000) (0)
In Vivo Visualization of Stat3 Activation in Myeloid Cells during Inflammation and Tumor Growth. (2004) (0)
Regulation of Signal Transducers and Activators of Transcription by Src Family Kinase in AML. (2005) (0)
1129: The Expression and Role of Foxatranscription Factor Proteins in Prostate Cancer Progression (2007) (0)
Inhibition of the IL-6/STAT3 signaling pathway for therapeutic intervention in prostate carcinogenesis and cancer cell differentiation (2013) (0)
PROCEDE DE PREDICTION DE LA REACTIVITE A UNE CHIMIOTHERAPIE ET DE SELECTION DE TRAITEMENTS (2007) (0)

This paper list is powered by the following services:

What Schools Are Affiliated With Richard L. Jove?

Richard L. Jove is affiliated with the following schools:

Richard L. Jove's Academic­Influence.com Rankings

Why Is Richard L. Jove Influential?

Richard L. Jove's Published Works

Published Works

What Schools Are Affiliated With Richard L. Jove?

Richard L. Jove's AcademicInfluence.com Rankings