Richard A. Young | Academic Influence

Richard A. Young's AcademicInfluence.com Rankings

Richard A. Young

Biology

#1081

World Rank

#1860

Historical Rank

#566

USA Rank

Molecular Biology

#145

World Rank

#149

Historical Rank

#77

USA Rank

Genetics

#146

World Rank

#185

Historical Rank

#88

USA Rank

biology Degrees

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Biology

Richard A. Young's Degrees

PhD Biochemistry Stanford University

Why Is Richard A. Young Influential?

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According to Wikipedia, Richard Allen Young is an American geneticist, a Member of Whitehead Institute, and a professor of biology at the Massachusetts Institute of Technology. He is a pioneer in the systems biology of gene control who has developed genomics technologies and concepts key to understanding gene control in human health and disease. He has served as an advisor to the World Health Organization and the National Institutes of Health. He is a member of the National Academy of Sciences and the National Academy of Medicine. Scientific American has recognized him as one of the top 50 leaders in science, technology and business. Young is among the most Highly Cited Researchers in his field.

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Richard A. Young's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Core Transcriptional Regulatory Circuitry in Human Embryonic Stem Cells (2005) (4503)
Histone H3K27ac separates active from poised enhancers and predicts developmental state (2010) (3345)
Transcriptional Regulatory Networks in Saccharomyces cerevisiae (2002) (3179)
Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes (2013) (2926)
Super-Enhancers in the Control of Cell Identity and Disease (2013) (2671)
Polycomb complexes repress developmental regulators in murine embryonic stem cells (2006) (2592)
BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc (2011) (2474)
Control of Developmental Regulators by Polycomb in Human Embryonic Stem Cells (2006) (2393)
Transcriptional regulatory code of a eukaryotic genome (2004) (2362)
Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers (2013) (2213)
A Chromatin Landmark and Transcription Initiation at Most Promoters in Human Cells (2007) (1979)
Mediator and Cohesin Connect Gene Expression and Chromatin Architecture (2010) (1714)
Dissecting the Regulatory Circuitry of a Eukaryotic Genome (1998) (1585)
Genome-wide Map of Nucleosome Acetylation and Methylation in Yeast (2005) (1546)
Genome-wide location and function of DNA binding proteins. (2000) (1534)
Efficient isolation of genes by using antibody probes. (1983) (1524)
Connecting microRNA Genes to the Core Transcriptional Regulatory Circuitry of Embryonic Stem Cells (2008) (1428)
Stem Cells, the Molecular Circuitry of Pluripotency and Nuclear Reprogramming (2008) (1417)
Remodeling of yeast genome expression in response to environmental changes. (2001) (1412)
Control of Pancreas and Liver Gene Expression by HNF Transcription Factors (2004) (1346)
Coactivator condensation at super-enhancers links phase separation and gene control (2018) (1303)
Transcriptional Amplification in Tumor Cells with Elevated c-Myc (2012) (1299)
c-Myc Regulates Transcriptional Pause Release (2010) (1219)
E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints. (2002) (1170)
Targeted recruitment of Set1 histone methylase by elongating Pol II provides a localized mark and memory of recent transcriptional activity. (2003) (1163)
Transcriptional Regulation and Its Misregulation in Disease (2013) (1124)
Control of the Embryonic Stem Cell State (2011) (1122)
A Phase Separation Model for Transcriptional Control (2017) (1072)
Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues. (2005) (979)
Transcription of eukaryotic protein-coding genes. (2000) (938)
Densely Interconnected Transcriptional Circuits Control Cell States in Human Hematopoiesis (2011) (887)
Divergent Transcription from Active Promoters (2008) (879)
Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains (2018) (864)
Editing DNA Methylation in the Mammalian Genome (2016) (853)
NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth (2006) (840)
Yeast RNA polymerase II genes: isolation with antibody probes. (1983) (804)
Control of Cell Identity Genes Occurs in Insulated Neighborhoods in Mammalian Chromosomes (2014) (782)
RNA polymerase stalling at developmental control genes in the Drosophila melanogaster embryo (2007) (770)
Activation of proto-oncogenes by disruption of chromosome neighborhoods (2015) (769)
Chromatin immunoprecipitation and microarray-based analysis of protein location (2006) (762)
Foxp3 occupancy and regulation of key target genes during T-cell stimulation (2007) (753)
Human macrophage activation programs induced by bacterial pathogens (2002) (749)
Poised Chromatin at the ZEB1 Promoter Enables Breast Cancer Cell Plasticity and Enhances Tumorigenicity (2013) (729)
Serial Regulation of Transcriptional Regulators in the Yeast Cell Cycle (2001) (710)
Transcriptional Addiction in Cancer (2017) (681)
Computational discovery of gene modules and regulatory networks (2003) (660)
Targeting transcription regulation in cancer with a covalent CDK7 inhibitor (2014) (646)
Systematic Identification of Culture Conditions for Induction and Maintenance of Naive Human Pluripotency (2014) (629)
An RNA polymerase II holoenzyme responsive to activators (1994) (620)
Discovery and characterization of super-enhancer-associated dependencies in diffuse large B cell lymphoma. (2013) (617)
YY1 Is a Structural Regulator of Enhancer-Promoter Loops (2017) (588)
An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element (2014) (570)
Insights into host responses against pathogens from transcriptional profiling (2005) (559)
Master Transcription Factors Determine Cell-Type-Specific Responses to TGF-β Signaling (2011) (558)
Enhancer decommissioning by LSD1 during embryonic stem cell differentiation (2012) (543)
Revisiting Global Gene Expression Analysis (2012) (537)
Mutations of RNA and protein sequences involved in human immunodeficiency virus type 1 packaging result in production of noninfectious virus (1990) (528)
Tcf3 is an integral component of the core regulatory circuitry of embryonic stem cells. (2008) (516)
Evidence for an instructive mechanism of de novo methylation in cancer cells (2006) (501)
Epitope tagging and protein surveillance. (1991) (491)
Stress proteins, infection, and immune surveillance (1989) (482)
A multisubunit complex associated with the RNA polymerase II CTD and TATA-binding protein in yeast (1993) (482)
BRCA1 is a component of the RNA polymerase II holoenzyme. (1997) (480)
CDK7 Inhibition Suppresses Super-Enhancer-Linked Oncogenic Transcription in MYCN-Driven Cancer (2014) (475)
The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset (2011) (471)
Using Graphical Models and Genomic Expression Data to Statistically Validate Models of Genetic Regulatory Networks (2000) (451)
Stress proteins are immune targets in leprosy and tuberculosis. (1988) (443)
Genome-Wide Distribution of ORC and MCM Proteins in S. cerevisiae: High-Resolution Mapping of Replication Origins (2001) (441)
Temporal regulation of RNA polymerase II by Srb10 and Kin28 cyclin-dependent kinases. (1998) (439)
Response and resistance to BET bromodomain inhibitors in triple negative breast cancer (2015) (437)
Chromatin structure and gene expression programs of human embryonic and induced pluripotent stem cells. (2010) (436)
Wnt signaling promotes reprogramming of somatic cells to pluripotency. (2008) (435)
A kinase–cyclin pair in the RNA polymerase II holoenzyme (1995) (433)
Chromosomal landscape of nucleosome-dependent gene expression and silencing in yeast (1999) (414)
Divergent transcription of long noncoding RNA/mRNA gene pairs in embryonic stem cells (2013) (412)
DHODH modulates transcriptional elongation in the neural crest and melanoma (2011) (410)
Rapid analysis of the DNA-binding specificities of transcription factors with DNA microarrays (2004) (398)
Parkinson-associated risk variant in distal enhancer of α-synuclein modulates target gene expression (2016) (395)
Derivation of Pre-X Inactivation Human Embryonic Stem Cells under Physiological Oxygen Concentrations (2010) (394)
Short RNAs are transcribed from repressed polycomb target genes and interact with polycomb repressive complex-2. (2010) (388)
Association of Cdk-activating kinase subunits with transcription factor TFIIH (1995) (382)
RNA Polymerase II Holoenzyme Contains SWI/SNF Regulators Involved in Chromatin Remodeling (1996) (382)
Redundant roles for the TFIID and SAGA complexes in global transcription (2000) (379)
Eucaryotic RNA polymerase conditional mutant that rapidly ceases mRNA synthesis (1987) (376)
Global and Hox-specific roles for the MLL1 methyltransferase. (2005) (373)
Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation (2013) (373)
Targeting transcriptional addictions in small cell lung cancer with a covalent CDK7 inhibitor. (2014) (367)
Convergence of developmental and oncogenic signaling pathways at transcriptional super-enhancers. (2015) (355)
Transcription factor trapping by RNA in gene regulatory elements (2015) (348)
3D Chromosome Regulatory Landscape of Human Pluripotent Cells. (2016) (347)
Exchange of RNA polymerase II initiation and elongation factors during gene expression in vivo. (2002) (346)
Mir-214-dependent regulation of the polycomb protein Ezh2 in skeletal muscle and embryonic stem cells. (2009) (341)
H2AZ Is Enriched at Polycomb Complex Target Genes in ES Cells and Is Necessary for Lineage Commitment (2008) (337)
Negative regulation of Gcn4 and Msn2 transcription factors by Srb10 cyclin-dependent kinase. (2001) (335)
SetDB1 contributes to repression of genes encoding developmental regulators and maintenance of ES cell state. (2009) (332)
Pol II phosphorylation regulates a switch between transcriptional and splicing condensates (2019) (329)
A common set of gene regulatory networks links metabolism and growth inhibition. (2004) (329)
Insulated Neighborhoods: Structural and Functional Units of Mammalian Gene Control (2016) (328)
Combining Location and Expression Data for Principled Discovery of Genetic Regulatory Network Models (2001) (326)
Dissection of Mycobacterium tuberculosis antigens using recombinant DNA. (1985) (320)
Whole-genome ChIP-chip analysis of Dorsal, Twist, and Snail suggests integration of diverse patterning processes in the Drosophila embryo. (2007) (317)
CDK7-Dependent Transcriptional Addiction in Triple-Negative Breast Cancer (2015) (311)
Humoral and cell-mediated immune responses to live recombinant BCG–HIV vaccines (1991) (309)
Genes for the major protein antigens of the leprosy parasite Mycobacterium leprae (1985) (300)
The RNA polymerase II holoenzyme and its implications for gene regulation. (1995) (300)
A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation (2016) (297)
Prokaryotic and eukaryotic RNA polymerases have homologous core subunits. (1987) (295)
Genome-wide location and regulated recruitment of the RSC nucleosome-remodeling complex. (2002) (294)
Lineage Regulators Direct BMP and Wnt Pathways to Cell-Specific Programs during Differentiation and Regeneration (2011) (292)
Rescue of Fragile X Syndrome Neurons by DNA Methylation Editing of the FMR1 Gene (2018) (288)
Efficient mapping of protein antigenic determinants. (1986) (282)
Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation. (2017) (282)
Global transcriptional and translational repression in human-embryonic-stem-cell-derived Rett syndrome neurons. (2013) (280)
Functional redundancy and structural polymorphism in the large subunit of RNA polymerase II (1987) (277)
Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia. (2012) (276)
Heat shock fusion proteins as vehicles for antigen delivery into the major histocompatibility complex class I presentation pathway. (1997) (272)
Transcriptional role of cyclin D1 in development revealed by a genetic–proteomic screen (2010) (269)
Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia. (2008) (269)
Stress proteins may provide a link between the immune response to infection and autoimmunity. (1989) (268)
A single mouse α-amylase gene specifies two different tissue-specific mRNAs (1981) (267)
Global position and recruitment of HATs and HDACs in the yeast genome. (2004) (261)
Intragenic and extragenic suppressors of mutations in the heptapeptide repeat domain of Saccharomyces cerevisiae RNA polymerase II. (1989) (261)
Activated Signal Transduction Kinases Frequently Occupy Target Genes (2006) (260)
T cell-derived IL-10 antagonizes macrophage function in mycobacterial infection. (1997) (259)
Global and gene‐specific analyses show distinct roles for Myod and Myog at a common set of promoters (2006) (255)
Naturally processed viral peptides recognized by cytotoxic T lymphocytes on cells chronically infected by human immunodeficiency virus type 1 (1994) (255)
General requirement for RNA polymerase II holoenzymes in vivo. (1995) (254)
Two dissociable subunits of yeast RNA polymerase II stimulate the initiation of transcription at a promoter in vitro. (1991) (252)
Long-term culture and fine specificity of human cytotoxic T-lymphocyte clones reactive with human immunodeficiency virus type 1. (1989) (250)
Small-molecule RORγt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms. (2014) (249)
HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages (2003) (243)
Program-Specific Distribution of a Transcription Factor Dependent on Partner Transcription Factor and MAPK Signaling (2003) (242)
Genetic predisposition to neuroblastoma mediated by a LMO1 super-enhancer polymorphism (2015) (241)
Recurrent somatic mutations in POLR2A define a distinct subset of meningiomas (2016) (236)
T lymphocytes from healthy individuals with specificity to self-epitopes shared by the mycobacterial and human 65-kilodalton heat shock protein. (1989) (235)
Binding of pRB to the PHD protein RBP2 promotes cellular differentiation. (2005) (232)
The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes (2009) (226)
Enhancer features that drive formation of transcriptional condensates (2018) (222)
Adjuvant-free hsp70 fusion protein system elicits humoral and cellular immune responses to HIV-1 p24. (1996) (221)
Core transcriptional regulatory circuitry in human hepatocytes (2006) (219)
Increased Antimycobacterial Immunity in Interleukin-10-Deficient Mice (1999) (217)
The long noncoding RNA Wisper controls cardiac fibrosis and remodeling (2017) (217)
RNA Polymerase II Holoenzymes and Subcomplexes* (1998) (216)
Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors. (2016) (213)
An activator target in the RNA polymerase II holoenzyme. (1998) (211)
Super-Enhancer-Mediated RNA Processing Revealed by Integrative MicroRNA Network Analysis (2017) (207)
An unusual eukaryotic protein phosphatase required for transcription by RNA polymerase II and CTD dephosphorylation in S. cerevisiae. (1999) (207)
Manipulation and potentiation of antimycobacterial immunity using recombinant bacille Calmette-Guérin strains that secrete cytokines. (1996) (205)
Complementary sequences 1700 nucleotides apart form a ribonuclease III cleavage site in Escherichia coli ribosomal precursor RNA. (1978) (203)
Models of human core transcriptional regulatory circuitries (2016) (198)
Coordinated binding of NF-kappaB family members in the response of human cells to lipopolysaccharide. (2006) (194)
RNA-Mediated Feedback Control of Transcriptional Condensates (2020) (192)
The yeast A kinases differentially regulate iron uptake and respiratory function. (2000) (191)
Genome-wide maps of histone modifications unwind in vivo chromatin states of the hair follicle lineage. (2011) (191)
Deciphering gene expression regulatory networks. (2002) (189)
Partitioning of cancer therapeutics in nuclear condensates (2020) (187)
Author Correction: Integrated genomic analyses of de novo pathways underlying atypical meningiomas (2018) (185)
Regulation of gene expression by TBP-associated proteins. (1998) (182)
Biomolecular Condensates in the Nucleus. (2020) (181)
A chemoattractant cytokine associated with granulomas in tuberculosis and silicosis. (1997) (180)
Tissue-specific expression of mouse α-amylase genes: Nucleotide sequence of isoenzyme mRNAs from pancreas and salivary gland (1980) (179)
Epigenomic analysis detects aberrant super-enhancer DNA methylation in human cancer (2016) (177)
Gene replacement and expression of foreign DNA in mycobacteria (1990) (172)
RNA polymerase II subunit RPB4 is essential for high- and low-temperature yeast cell growth (1989) (170)
Identification of the gal4 suppressor Sug1 as a subunit of the yeast 26S proteasome (1996) (166)
A novel transcription factor reveals a functional link between the RNA polymerase II CTD and TFIID (1992) (166)
A mammalian SRB protein associated with an RNA polymerase II holoenzyme (1996) (163)
Tumor necrosis factor α is a determinant of pathogenesis and disease progression in mycobacterial infection in the central nervous system (1999) (162)
A proposed mechanism for the induction of cytotoxic T lymphocyte production by heat shock fusion proteins. (2000) (162)
X-linked H3K27me3 demethylase Utx is required for embryonic development in a sex-specific manner (2012) (157)
Attenuated Host Resistance againstMycobacterium bovis BCG Infection in Mice Lacking Osteopontin (1999) (155)
Subunits shared by eukaryotic nuclear RNA polymerases. (1990) (155)
The genome-wide localization of Rsc9, a component of the RSC chromatin-remodeling complex, changes in response to stress. (2002) (155)
The ribonuclease III site flanking 23S sequences in the 30S ribosomal precursor RNA of E. coli (1980) (153)
Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry (2018) (148)
RNA polymerase II C-terminal repeat influences response to transcriptional enhancer signals (1990) (146)
Global Control of Motor Neuron Topography Mediated by the Repressive Actions of a Single Hox Gene (2010) (145)
Genome-wide analysis of the H3K4 histone demethylase RBP2 reveals a transcriptional program controlling differentiation. (2008) (143)
Integrated genomic analyses of de novo pathways underlying atypical meningiomas (2017) (143)
Mapping of T cell epitopes using recombinant antigens and synthetic peptides. (1987) (141)
A portion of RNA polymerase II molecules has a component essential for stress responses and stress survival (1993) (140)
Genome-wide localization of small molecules (2013) (140)
Human T-cell clones recognize a major M. leprae protein antigen expressed in E. coli (1986) (140)
The developmental potential of iPSCs is greatly influenced by reprogramming factor selection. (2014) (139)
Pocket Protein Complexes Are Recruited to Distinct Targets in Quiescent and Proliferating Cells (2005) (139)
Aire unleashes stalled RNA polymerase to induce ectopic gene expression in thymic epithelial cells (2011) (138)
Ligand-dependent dynamics of retinoic acid receptor binding during early neurogenesis (2011) (136)
In Vivo Cytotoxic T Lymphocyte Elicitation by Mycobacterial Heat Shock Protein 70 Fusion Proteins Maps to a Discrete Domain and Is Cd4+ T Cell Independent (2000) (135)
Engineering pathways for malate degradation in Saccharomyces cerevisiae (1997) (134)
MYC Drives a Subset of High-Risk Pediatric Neuroblastomas and Is Activated through Mechanisms Including Enhancer Hijacking and Focal Enhancer Amplification. (2018) (134)
A CD47-associated super-enhancer links pro-inflammatory signalling to CD47 upregulation in breast cancer (2017) (133)
A Systematic Approach to Identify Candidate Transcription Factors that Control Cell Identity (2015) (132)
Parkinson-associated risk variant in enhancer element produces subtle effect on target gene expression (2016) (132)
Saltatory remodeling of Hox chromatin in response to rostro-caudal patterning signals (2013) (132)
[51] Gene isolation by screening λgt11 libraries with antibodies (1987) (131)
Reverse-transcribed SARS-CoV-2 RNA can integrate into the genome of cultured human cells and can be expressed in patient-derived tissues (2021) (130)
A set of genes critical to development is epigenetically poised in mouse germ cells from fetal stages through completion of meiosis (2013) (129)
CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation (2018) (127)
Functional association of Gdown1 with RNA polymerase II poised on human genes (2011) (126)
Mediator Condensates Localize Signaling Factors to Key Cell Identity Genes. (2019) (126)
RNA polymerase II subunit composition, stoichiometry, and phosphorylation (1990) (124)
Maximum-likelihood estimation of optimal scaling factors for expression array normalization (2001) (124)
Recombinant Mycobacterium bovis BCG secreting functional interleukin-2 enhances gamma interferon production by splenocytes (1994) (121)
Chromatin proteomic profiling reveals novel proteins associated with histone-marked genomic regions (2015) (120)
Interplay of Positive and Negative Regulators in Transcription Initiation by RNA Polymerase II Holoenzyme (1998) (117)
Mouse liver and salivary gland α-amylase mRNAs differ only in 5′ non-translated sequences (1981) (114)
Identification of a cancer stem cell-specific function for the histone deacetylases, HDAC1 and HDAC7, in breast and ovarian cancer (2016) (113)
Transcriptional Dysregulation of MYC Reveals Common Enhancer-Docking Mechanism (2018) (113)
Multiple polyadenylation sites in a mouse α-amylase gene (1981) (113)
Gene induction and repression during terminal erythropoiesis are mediated by distinct epigenetic changes. (2011) (112)
The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development. (2012) (112)
Ronin/Hcf-1 binds to a hyperconserved enhancer element and regulates genes involved in the growth of embryonic stem cells. (2010) (112)
The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia (2013) (111)
CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription (1997) (108)
The core centromere and Sgo1 establish a 50-kb cohesin-protected domain around centromeres during meiosis I. (2005) (107)
Systematic analysis of essential yeast TAFs in genome‐wide transcription and preinitiation complex assembly (2003) (105)
Cumulative Toll-Like Receptor Activation in Human Macrophages Treated with Whole Bacteria1 (2003) (104)
Zebrafish promoter microarrays identify actively transcribed embryonic genes (2006) (103)
Multiple Structural Maintenance of Chromosome Complexes at Transcriptional Regulatory Elements (2013) (103)
ZFHX4 interacts with the NuRD core member CHD4 and regulates the glioblastoma tumor-initiating cell state. (2014) (102)
Systematic Identification of Culture Conditions for Induction and Maintenance of Naive Human Pluripotency (2014) (102)
Vaccinia virus infection induces a stress response that leads to association of Hsp70 with viral proteins (1992) (100)
Broad, but not universal, transcriptional requirement for yTAFII17, a histone H3-like TAFII present in TFIID and SAGA. (1998) (99)
Sequence of the 16 S-23 s spacer region in two ribosomal RNA operons of Escherichia coli. (1979) (99)
High-resolution computational models of genome binding events (2006) (98)
MYC and transcription elongation. (2014) (97)
EWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing Sarcoma. (2018) (94)
Cross-Cohort Analysis Identifies a TEAD4-MYCN Positive Feedback Loop as the Core Regulatory Element of High-Risk Neuroblastoma. (2018) (92)
Biomolecular condensates and cancer. (2020) (91)
The Msx1 Homeoprotein Recruits Polycomb to the Nuclear Periphery during Development. (2011) (90)
Nanog-like regulates endoderm formation through the Mxtx2-Nodal pathway. (2012) (89)
The uraA locus and homologous recombination in Mycobacterium bovis BCG (1993) (89)
A hypothesis-based approach for identifying the binding specificity of regulatory proteins from chromatin immunoprecipitation data (2006) (88)
Tandem promoters direct E. coli ribosomal RNA synthesis (1979) (88)
Yeast NC2 Associates with the RNA Polymerase II Preinitiation Complex and Selectively Affects Transcription In Vivo (2001) (87)
Lambda gt 11: gene isolation with antibody probes and other applications. (1987) (86)
lncRNA DIGIT and BRD3 protein form phase-separated condensates to regulate endoderm differentiation (2019) (86)
The etiologic agents of leprosy and tuberculosis share an immunoreactive protein antigen with the vaccine strain Mycobacterium bovis BCG (1987) (86)
Yeast RNA polymerase II subunit RPB9 is essential for growth at temperature extremes. (1991) (86)
Hematopoietic Remodeling in Interferon-γ–Deficient Mice Infected With Mycobacteria (1998) (85)
Bayesian Methods for Elucidating Genetic Regulatory Networks (2002) (84)
Ten years of genetics and genomics: what have we achieved and where are we heading? (2010) (82)
RPB7, one of two dissociable subunits of yeast RNA polymerase II, is essential for cell viability (1993) (81)
RNA polymerase II carboxy-terminal domain contributes to the response to multiple acidic activators in vitro. (1991) (80)
Human T cell clones recognize two abundant Mycobacterium tuberculosis protein antigens expressed in Escherichia coli. (1987) (80)
MeCP2 links heterochromatin condensates and neurodevelopmental disease (2020) (80)
Immune responses induced by BCG recombinant for human papillomavirus L1 and E7 proteins. (2000) (80)
Conditional mutations occur predominantly in highly conserved residues of RNA polymerase II subunits (1990) (79)
Suppression of Adaptive Responses to Targeted Cancer Therapy by Transcriptional Repression. (2017) (79)
Analysis of the mouse embryonic stem cell regulatory networks obtained by ChIP-chip and ChIP-PET (2008) (77)
Osteopontin expression correlates with clinical outcome in patients with mycobacterial infection. (2000) (77)
BORIS promotes chromatin regulatory interactions in treatment-resistant cancer cells (2019) (75)
The SETDB1 histone methyltransferase is recurrently amplified in and accelerates melanoma (2011) (75)
Transcriptional regulatory networks downstream of TAL1/SCL in T-cell acute lymphoblastic leukemia. (2005) (74)
Functional antagonism between RNA polymerase II holoenzyme and global negative regulator NC2 in vivo. (1997) (74)
Ubiquitous expression and embryonic requirement for RNA polymerase II coactivator subunit Srb7 in mice. (1999) (74)
RNA polymerase II: subunit structure and function. (1990) (70)
A protein antigen of Mycobacterium leprae is related to a family of small heat shock proteins (1988) (68)
Characterization of antibody-reactive epitopes on the 65-kilodalton protein of Mycobacterium leprae (1987) (68)
RNA polymerase II subunit RPB3 is an essential component of the mRNA transcription apparatus (1989) (67)
The mouse alpha-amylase multigene family. Sequence organization of members expressed in the pancreas, salivary gland and liver. (1982) (67)
Mutations in the three largest subunits of yeast RNA polymerase II that affect enzyme assembly (1991) (66)
The rate of protein synthesis in hematopoietic stem cells is limited partly by 4E-BPs (2016) (66)
Tumor necrosis factor alpha is a determinant of pathogenesis and disease progression in mycobacterial infection in the central nervous system. (1999) (65)
Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma. (2016) (65)
Studies of cloned simian immunodeficiency virus-specific T lymphocytes. gag-specific cytotoxic T lymphocytes exhibit a restricted epitope specificity. (1990) (63)
Cell Cycle Genes Are the Evolutionarily Conserved Targets of the E2F4 Transcription Factor (2007) (63)
Stress and immunological recognition in host-pathogen interactions (1992) (62)
Gene isolation with human T lymphocyte probes. Isolation of a gene that expresses an epitope recognized by T cells specific for Mycobacterium bovis BCG and pathogenic mycobacteria. (1988) (61)
Regulatory targets in the RNA polymerase II holoenzyme. (1998) (61)
Small genomic insertions form enhancers that misregulate oncogenes (2017) (61)
RNA polymerase II mutants defective in transcription of a subset of genes (1990) (60)
Induction of human hsp60 expression in monocytic cell lines. (1992) (59)
Genes for the major protein antigens of Mycobacterium tuberculosis: the etiologic agents of tuberculosis and leprosy share an immunodominant antigen. (1987) (59)
Transcriptional activating regions target a cyclin-dependent kinase (2002) (58)
Systematic Identification of Culture Conditions for Induction and Maintenance of Naive Human Pluripotency (2014) (57)
Activation of the p53 Transcriptional Program Sensitizes Cancer Cells to Cdk7 Inhibitors. (2017) (57)
A genome-scale in vivo loss-of-function screen identifies Phf6 as a lineage-specific regulator of leukemia cell growth (2015) (56)
Transposition of the Escherichia coli insertion element gamma generates a five-base-pair repeat. (1979) (54)
BET bromodomain proteins regulate enhancer function during adipogenesis (2018) (54)
Dynamic Enhancer DNA Methylation as Basis for Transcriptional and Cellular Heterogeneity of ESCs. (2019) (53)
Mutations in a conserved region of RNA polymerase II influence the accuracy of mRNA start site selection. (1991) (52)
Direct Lineage Conversion of Adult Mouse Liver Cells and B Lymphocytes to Neural Stem Cells (2014) (51)
Transcription termination in the Escherichia coli ribosomal RNA operon rrnC. (1979) (51)
Activating Phosphorylation of the Kin28p Subunit of Yeast TFIIH by Cak1p (1999) (50)
Let-7 represses Nr6a1 and a mid-gestation developmental program in adult fibroblasts. (2013) (50)
A 28-kDa protein from Mycobacterium leprae is a target of the human antibody response in lepromatous leprosy. (1988) (49)
Cdk1 Controls Global Epigenetic Landscape in Embryonic Stem Cells. (2020) (48)
A gene from Mycobacterium tuberculosis which is homologous to the DnaJ heat shock protein of E. coli. (1988) (48)
Embryonic stem cell-based mapping of developmental transcriptional programs (2011) (47)
Constructing and screening complementary dna libraries in lambda gt 10 and lambda gt 11 (1985) (47)
APOBEC signature mutation generates an oncogenic enhancer that drives LMO1 expression in T-ALL (2017) (47)
Activation of the LMO2 oncogene through a somatically acquired neomorphic promoter in T-cell acute lymphoblastic leukemia. (2016) (45)
Hematopoietic remodeling in interferon-gamma-deficient mice infected with mycobacteria. (1998) (45)
The kinetics of specific immune responses in rhesus monkeys inoculated with live recombinant BCG expressing SIV Gag, Pol, Env, and Nef proteins. (2000) (45)
In vivo and in vitro characterization of murine T-cell clones reactive to Mycobacterium tuberculosis (1987) (44)
Heat shock proteins as immunological carriers and vaccines. (1996) (43)
Yeast RNA polymerase II subunit RPB11 is related to a subunit shared by RNA polymerase I and III. (1993) (43)
ASCL1 is a MYCN- and LMO1-dependent member of the adrenergic neuroblastoma core regulatory circuitry (2019) (43)
Screening of a recombinant mycobacterial DNA library with polyclonal antiserum and molecular weight analysis of expressed antigens (1987) (43)
A Role for Toll-Like Receptor 4 in Dendritic Cell Activation and Cytolytic CD8+ T Cell Differentiation in Response to a Recombinant Heat Shock Fusion Protein1 (2004) (42)
High MITF Expression Is Associated with Super-Enhancers and Suppressed by CDK7 Inhibition in Melanoma. (2018) (41)
TOX Regulates Growth, DNA Repair, and Genomic Instability in T-cell Acute Lymphoblastic Leukemia. (2017) (39)
Embryonic stem cell-based system for mapping developmental transcriptional programs (2011) (38)
Mapping key features of transcriptional regulatory circuitry in embryonic stem cells. (2008) (38)
Repressive Transcription (2010) (37)
PHF6 regulates phenotypic plasticity through chromatin organization within lineage-specific genes (2017) (37)
Genome-wide determination of drug localization (2013) (37)
SARS-CoV-2 RNA reverse-transcribed and integrated into the human genome (2020) (36)
CpG island structure and trithorax/polycomb chromatin domains in human cells. (2012) (35)
Transcriptional regulation: contending with complexity. (1999) (35)
RNA polymerase II subunit RPB10 is essential for yeast cell viability. (1990) (35)
Testing the super-enhancer concept (2021) (33)
RNA in formation and regulation of transcriptional condensates (2021) (32)
Erratum: NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth (Proceedings of the National Academy of Sciences of the United States of America (2006) 103, 48, (18261-18266) DOI: 10.1073/pnas.0606108103) (2007) (32)
Regulation and Dysregulation of Chromosome Structure in Cancer (2018) (30)
Pharmacological perturbation of CDK 9 using selective CDK 9 inhibition or degradation (2018) (30)
Systems biology. Accurate information transmission through dynamic biochemical signaling networks. (2014) (30)
A highly potent artificial transcription factor. (2002) (29)
D-cyclins repress apoptosis in hematopoietic cells by controlling death receptor Fas and its ligand FasL. (2014) (29)
Immunoscreening λgtll Recombinant DNA Expression Libraries (1985) (29)
KEX2 mutations suppress RNA polymerase II mutants and alter the temperature range of yeast cell growth (1989) (27)
STAG2 loss rewires oncogenic and developmental programs to promote metastasis in Ewing sarcoma. (2021) (26)
Predicting master transcription factors from pan-cancer expression data (2019) (26)
Transcriptional super-enhancers connected to cell identity and disease (2013) (26)
Genetic exploration of interactive domains in RNA polymerase II subunits (1990) (26)
Gene isolation by screening lambda gt11 libraries with antibodies. (1987) (25)
[40] Cloning cDNA into λgt10 and λgt11 (1987) (25)
Genes encoding transcription factor IIIA and the RNA polymerase common subunit RPB6 are divergently transcribed in Saccharomyces cerevisiae. (1992) (25)
Bayesian Estimation of Transcript Levels Using a General Model of Array Measurement Noise (2003) (24)
A Role for Toll-Like Receptor 4 in Dendritic Cell Activation and Cytolytic CD8 T Cell Differentiation in Response to a Recombinant Heat Shock Fusion Protein (2004) (22)
LIN28B regulates transcription and potentiates MYCN-induced neuroblastoma through binding to ZNF143 at target gene promotors (2020) (21)
Function and structure in phage Qbeta RNA replicase. Association of EF-Tu-Ts with the other enzyme subunits. (1976) (21)
A single mouse alpha-amylase gene specifies two different tissue-specific mRNAs. (1981) (21)
Cloning of the RNA2 gene of Saccharomyces cerevisiae. (1984) (20)
A bayesian approach to transcript estimation from gene array data: the BEAM technique (2002) (19)
SMC complexes link gene expression and genome architecture. (2014) (18)
Identification of mycobacterial antigens recognized by T lymphocytes. (1989) (18)
Cell-specific transcriptional control of mitochondrial metabolism by TIF1γ drives erythropoiesis (2021) (18)
Exploring RNA polymerase II structure and function (1994) (18)
Mediator and cohesin connect gene expression and chromatin architecture (2011) (17)
The TAL 1 complex targets the FBXW 7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia (2013) (17)
Epitope tagging of the human endoplasmic reticulum HSP70 protein, BiP, to facilitate analysis of BiP--substrate interactions. (1995) (17)
JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia (2018) (17)
Genetic variation associated with condensate dysregulation in disease. (2022) (16)
Development of a BCG recombinant vehicle for candidate AIDS vaccines. (1990) (16)
Baculoviral transfer vectors for expression of FLAG fusion proteins in insect cells. (1997) (15)
Connecting transcriptional control to chromosome structure and human disease. (2010) (15)
TRIB2 reinforces the oncogenic transcriptional program controlled by the TAL1 complex in T-cell acute lymphoblastic leukemia (2015) (15)
Common variants in signaling transcription-factor-binding sites drive phenotypic variability in red blood cell traits (2020) (15)
The identification of T cell epitopes in Mycobacterium tuberculosis using human T lymphocyte clones. (1986) (14)
Evidence That Gene Activation and Silencing during Stem Cell Differentiation Requires a Transcriptionally Paused Intermediate State (2011) (14)
Non-overlapping Control of Transcriptome by Promoter- and Super-Enhancer-Associated Dependencies in Multiple Myeloma (2018) (13)
Activation without a vital ingredient (1996) (13)
Human Hsp60: bacterial expression, purification, development of monoclonal antibodies and a sandwich ELISA for quantitation. (1994) (13)
Transcriptional Regulation of the Schizosaccharomyces pombe Malic Enzyme Gene, mae2 * (1999) (13)
Purification of yeast RNA polymerase II holoenzymes. (1996) (13)
Retinoic acid rewires the adrenergic core regulatory circuitry of childhood neuroblastoma (2021) (13)
Promoter-specific activation defects by a novel yeast TBP mutant compromised for TFIIB interaction (2001) (12)
Binding Proteins Genome-Wide Location and Function of DNA (2008) (11)
Cloning and identification of the gene coding for the 140‐kd subunit of Drosophila RNA polymerase II (1986) (11)
CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation (2020) (11)
Human Stress Protein hsp70: Overexpression in E. coli, Purification and Characterization (1995) (10)
Multiple polyadenylation sites in a mouse alpha-amylase gene. (1981) (10)
Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity (2021) (10)
Host factor for coliphage Qβ RNA replication: Presence in procaryotes and association with the 30S ribosomal subunit inEscherichia coli (1977) (9)
Phage Q-beta ribonucleic acid replicase. Subunit relationships determined by intramolecular cross-linking. (1975) (9)
New Insights into Genome Structure: Genes of a Feather Stick Together. (2017) (9)
Mouse liver and salivary gland alpha-amylase mRNAs differ only in 5' non-translated sequences. (1981) (9)
RNA polymerase II subunit RPB10 is essential for yeast cell viability. (1993) (8)
Response to Parry et al.: Strong evidence for genomic integration of SARS-CoV-2 sequences and expression in patient tissues (2021) (7)
Tissue specific expression of mouse alpha-amylase genes. (1982) (7)
Tailored tails and transcription initiation: the carboxyl terminal domain of RNA polymerase II. (1991) (7)
Yeast artificial chromosome targeting technology: an approach for the deletion of genes in the C57BL/6 mouse. (2001) (7)
Cloning cDNA into lambda gt10 and lambda gt11. (1987) (7)
1 RNA Polymerase Stalling at Developmental Control Genes in the Drosophila Embryo (2007) (7)
Fifty years after Jacob and Monod: what are the unanswered questions in molecular biology? (2011) (6)
A phase separation model predicts key features of transcriptional control (2017) (6)
Secretion of mammalian proteins from mycobacteria. (1998) (6)
Supplemental Data Core Transcriptional Regulatory Circuitry in Human Embryonic Stem Cells (2005) (6)
Classification of COVID-19 and Other Pathogenic Sequences: A Dinucleotide Frequency and Machine Learning Approach (2020) (6)
Genes for the protein antigens of the tuberculosis and leprosy bacilli (1985) (5)
Characterization of mycobacterial species specificity of 14 separate epitopes which reacted with monoclonal antibodies to the 65,000 molecular weight protein molecule of Mycobacterium leprae. (1986) (5)
Poised chromatin at the ZEB1 promoter enables cell plasticity and enhances tumorigenicity (2014) (5)
17 – λgt 11: Gene Isolation with Antibody Probes and Other Applications (1989) (5)
RNA Polymerase Stalling at Developmental Control Genes in the Drosophila Embryo – Supplementary Information (2007) (5)
The new vaccines. (1992) (5)
HLA class II restricted helper and suppressor clones reactive with Mycobacterium leprae. (1986) (5)
Immune Recognition of Stress Proteins in Infection and in Surveillance of Stressed Cells (1991) (5)
[15] Gene isolation with λgt11 system (1991) (5)
Erratum: High-resolution computational models of genome binding events (2006) (4)
New AIDS vaccine candidates: antigen delivery and design. (1991) (4)
Liao, S. M. et al. A kinase-cyclin pair in the RNA polymerase II holoenzyme. Nature 374, 193-196 (1995) (4)
Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry (2018) (4)
The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes. (2022) (4)
RECOMBINANT BCG VACCINES (2001) (3)
Author Correction: Enhancer decommissioning by LSD1 during embryonic stem cell differentiation (2018) (3)
Dissecting transcriptional circuitry and mechanisms in yeast (1999) (3)
Mutations in a conserved region of RNA polymerase II influence the accuracy of mRNA start site selection (1991) (3)
The identification of T cell epitopes inMycobacterium tuberculosisusing human T lymphocyte clones (1986) (3)
Bat pluripotent stem cells reveal unusual entanglement between host and viruses (2022) (2)
CDK13 Mutations Drive Melanoma via Accumulation of Prematurely Terminated Transcripts (2019) (2)
Abstract B16: Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer (2016) (2)
Abstract 5490: Non-overlapping promoter and super-enhancer-associated dependencies in multiple myeloma (2017) (2)
Reply to Briggs et al.: Genomic integration and expression of SARS-CoV-2 sequences can explain prolonged or recurrent viral RNA detection (2021) (2)
A MIR17HG-derived Long Noncoding RNA Provides an Essential Chromatin Scaffold for Protein Interaction and Myeloma Growth. (2022) (2)
Biomedical Discovery Review with Dna Arrays Are Obtained for a Variety of Different Tissues. a Direct Figure 2. Computational Approaches to Classifying and Displaying Patterns in Expression Profile Data (2000) (2)
Mapping of the Multiple Myeloma Transcriptional Core Regulatory Circuitry Reveals TCF3 As a Novel Dependency and an Oncogenic Collaborator of MYC (2017) (2)
11 – Stress Proteins as Immune Targets in Bacterial and Parasitic Infections (1990) (2)
Erratum: Targeting Transcriptional Addictions in Small Cell Lung Cancer with a Covalent CDK7 Inhibitor (Cancer Cell (2014) 26(6) (909–922) (S1535610814004231) (10.1016/j.ccell.2014.10.019)) (2015) (2)
Targeting Transcriptional Addictions in Small Cell Lung Cancer with a Covalent CDK 7 Inhibitor Citation (2014) (2)
Core Transcriptional Regulatory Circuit Controlled by the TAL1 Complex in T-Cell Acute Lymphoblastic Leukemia, (2011) (2)
Gene isolation with lambda gt11 system. (1991) (2)
Grounded: transcriptional pausing in naive mESCs. (2012) (2)
Abstract 4135:c-MYCdrives a subset of high-risk pediatric neuroblastoma and is activated through mechanisms including enhancer hijacking and focal enhancer amplification (2018) (1)
embryo Drosophilaintegration of diverse patterning processes in the Whole-genome ChIP-chip analysis of Dorsal, Twist, and Snail (2007) (1)
rRNA and tRNA Processing Signals in the rRNA Operons of Escherichia coli (1980) (1)
Corrigendum: Small genomic insertions form enhancers that misregulate oncogenes (2017) (1)
Solid phase peptide synthesis of epitopes that react with monoclonal antibodies to the 65,000 dalton protein of Mycobacterium leprae. (1986) (1)
Abstract 2007: Transcriptional regulatory program controlled by the oncogenic transcription factor LMO1 in neuroblastoma (2016) (1)
Abstract 2352: Defining a pediatric cancer dependency map (2018) (1)
CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation (2019) (1)
Chromatin Structure and Gene Expression Programs of Human Embryonic and Induced Pluripotent Stem Cells Citation (2010) (1)
Retinoic acid rewires the adrenergic core regulatory circuitry of neuroblastoma but can be subverted by enhancer hijacking of MYC or MYCN (2020) (1)
Chromatin Accessibility Profiling Reveals Cis-Regulatory Heterogeneity and Novel Transcription Factor Dependencies in Multiple Myeloma (2018) (1)
Abstract 2441: CDK12/13 inhibition cooperates with the Ewing sarcoma oncoprotein EWS/FLI to attenuate homologous recombination repair in Ewing sarcoma cells (2016) (1)
Leading Edge Perspective A Phase Separation Model for Transcriptional Control (2017) (1)
Abstract B10: Rhabdomyosarcoma requires MYC family genomic events to pathogenically subvert core-regulatory circuitry (2020) (1)
InVivoandInVitro Characterization ofMurineT-Cell Clones Reactive toMycobacterium tuberculosis (1987) (1)
STAG2 Mutations Alter Cohesin Ring Function and Provide Therapeutic Vulnerabilities in Acute Myeloid Leukemia (2018) (1)
The dynamic clustering of insulin receptor underlies its signaling and is disrupted in insulin resistance (2022) (1)
Disruption Of Super Enhancer-Driven Cancer Dependencies In Diffuse Large B-Cell Lymphoma (2013) (1)
The rate of protein synthesis in hematopoietic stem cells is limited partly by 4 E-BPs Citation Signer (2016) (1)
embryoDrosophila suggests integration of diverse patterning processes in the Whole-genome ChIP – chip analysis of Dorsal , Twist , and Snail data (2007) (1)
MINIREVIEW Stress andImmunological Recognition in Host-Pathogen Interactions (1992) (1)
Genome-Wide Transcriptional Regulatory Networks Downstream of TAL1/SCL in T-Cell Acute Lymphoblastic Leukemia. (2004) (1)
Transcriptional Signaling Centers Govern Human Erythropoiesis and Harbor Genetic Variations of Red Blood Cell Traits (2018) (0)
Leading Edge Primer Revisiting Global Gene Expression Analysis (2012) (0)
COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY VOLUME LXXIII (2009) (0)
Epigenomic analysis detects aberrant super-enhancer DNA methylation in human cancer (2016) (0)
Correction for Hsu et al., CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation (2021) (0)
New Insights into Genome Structure : Genes of a Feather Stick Together Citation Hnisz (2017) (0)
The Function and Structure of the Protein-Synthesis Elongation Factors Tu and Ts in Phage-Qβ Replicase (1978) (0)
Abstract A38: The role of MGA loss-of-function mutations in lung adenocarcinomas (2015) (0)
Cellular Maturation of Oligodendrocytes is Governed by Transient Gene Melting (2022) (0)
STAT3 cooperates with the core transcriptional regulatory circuitry to drive MYC expression and oncogenesis in anaplastic large cell lymphoma (2022) (0)
Association of Hsp7O with Viral Proteins (2003) (0)
The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes. (2022) (0)
Developmental Cell Nanog-like-Mxtx 2-Nodal Pathway in Endoderm Forming (2012) (0)
7.60 Cell Biology: Structure and Functions of the Nucleus, Spring 2006 (2006) (0)
Abstract 4189: Excess c-Myc loads tissue-specific enhancers in tumor cells (2012) (0)
2021 – TRANSCRIPTIONAL REGULATION OF MITOCHONDRIAL METABOLISM BY TIF1GAMMA DRIVES ERYTHROID PROGENITOR DIFFERENTIATION (2020) (0)
Efficient isolation of genes by using (2016) (0)
Identifying Long Noncoding RNA Dependencies Using CRISPR Interference (CRISPRi)-Based Platform in Multiple Myeloma (2021) (0)
Euplotid: A Linux-based platform to physically edit the genome (2017) (0)
1 Activation of the LMO 2 oncogene through a somatically acquired 1 neomorphic promoter in T-Cell Acute Lymphoblastic Leukemia 2 3 (2017) (0)
Abstract A44: The role of PHF6 in maintaining pre-B cell commitment in B-cell acute lymphoblastic leukemia (2016) (0)
Induction of cytotoxic lymphocytes by heat shock protein-fusion proteins depends on and is cd4 + regardless of the ATP-binding domain in hsp (2000) (0)
Abstract 15: Suppression of adaptive responses to targeted therapies by transcriptional inhibition (2017) (0)
Abstract PR14: Nucleation of transcriptional super-enhancers at tumor oncogenes (2015) (0)
Targeting MM at the Nexus between Cell Cycle and Transcriptional Regulation Via CDK7 Inhibition (2020) (0)
Skin cells Neurons Muscle cells Red blood cells Lung cells Pancreatic cells Pluripotent Multipotent Unipotent Blastocyst Ectoderm Mesoderm (0)
Author Correction: Enhancer decommissioning by LSD1 during embryonic stem cell differentiation (2018) (0)
Abstract 2062: Selective gene dependencies inMYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry (2018) (0)
Aberrant CDK7 Activity Drives the Cell Cycle and Transcriptional Dysregulation to Support Multiple Myeloma Growth: An Attractive Molecular Vulnerability (2021) (0)
regulation Myc enhancer-mediated Role of SWI / SNF in acute leukemia maintenance and Material Supplemental (2013) (0)
Oncogenic CDK13 mutations impede nuclear RNA surveillance (2023) (0)
Shock Fusion Protein Recombinant Differentiation in Response to a T Cell + Cell Activation and Cytolytic CD8 A Role for Toll-Like Receptor 4 in Dendritic (2004) (0)
Control of the Stem Cell Gene Expression Program (2013) (0)
Abstract 1118: Synthetic lethality of CDK12 inhibition in tumors with EWS/FLI rearrangements (2017) (0)
Abstract PR06: Nucleation of transcriptional super-enhancers at tumor oncogenes (2015) (0)
Genome-wide determination of drug localization this available. Please share how this access benefits you. Your story matters (2014) (0)
RNA POL YMERASE II (1991) (0)
Abstract IA19: MYC activation through enhancer hijacking or focal enhancer amplification drives a subset of high-risk pediatric neuroblastoma (2018) (0)
Abstract B22: Cell state and lineage specification are controlled by epigenetic landscapes regulating the core transcriptional regulatory circuitry in pediatric neuroblastoma (2020) (0)
Functional redundancy of two transcriptional coactivator complexes (1999) (0)
Title: c-MYC drives a subset of high-risk pediatric neuroblastomas and is activated through mechanisms including enhancer hijacking and focal enhancer amplification Authors: (2017) (0)
Targeting transcription in heart failure via CDK7/12/13 inhibition (2022) (0)
Abstract PR05: Targeting of CDK7 inhibits super-enhancer-associated oncogenic programs in MYCN-amplified tumor cells (2015) (0)
Understanding how transcriptional enhancers control over 20 , 000 protein-coding genes tomaintain cell-type-specific gene expression programs in all human cells is a fundamental challenge in regu (2016) (0)
Vaccins bcg recombines (1994) (0)
Efficient mapping of protein antigenic determinants ( monoclonal antibodies / kgtll expression vector / leprosy / Mycobacterium leprae ) (0)
Bayesian Methods for Transcript Level Estimation from Noisy Array Measurements (2001) (0)
adult fibroblasts and a mid-gestation developmental program in Nr 6 a 1 Let-7 represses Material Supplemental (2013) (0)
Oct4 Directs TGF-Beta Signaling in Embryonic Stem Cells (2011) (0)
Abstract 2004: Nucleation of transcriptional super-enhancers at tumor oncogenes by small insertions (2016) (0)
Abstract PR06: The reemergence of neural crest progenitor identity is a key event in the initiation of melanoma from a field of cancer-prone melanocytes (2016) (0)
786 TGF-β Signaling is Directed to the Targets of Master Transcription Factors (2010) (0)
The low rate of protein synthesis in hematopoietic stem cells is determined partly by hypophosphorylation of 4E-BPS (2016) (0)
Abstract PR11: EP300 controls the oncogenic enhancer landscape of high-risk neuroblastoma (2020) (0)
Inhibition of c-Myc Expression and Function in Hematologic Malignancies (2011) (0)
Abstract 971: Three-dimensional gene regulatory landscapes in normal and cancer cells (2018) (0)
A nuclear receptor facilitates differentiation of human PSCs into more mature hepatocytes (2022) (0)
Genetic Predisposition to Neuroblastoma Results from a Regulatory Polymorphism that Promotes the Adrenergic Cell State (2023) (0)
LYMPHOID NEOPLASIA Activation of the LMO2 oncogene through a somatically acquired neomorphic promoter in T-cell acute lymphoblastic leukemia (2017) (0)
Efficient Computation of BEAM Estimates (0)
Dissection of Mycobacterium tuberc recombinant DNA (Xgtll expression vector/monoclonal antibodies/human pathogens) (2016) (0)
P-099: Perturbation of CDK7 and super-enhancer driven transcriptional programs synergistically halts multiple myeloma cell proliferation (2021) (0)
Abstract PR04: Transcriptional regulation of mitochondrial metabolism by TIF1γ drives erythroid progenitor differentiation (2020) (0)
1305-P: Insulin Receptor Condensates in Insulin Sensitivity and Resistance (2022) (0)
Transcriptional Regulation of Coenzyme Q Biosynthesis By TIF1γ Drives Erythropoiesis (2019) (0)
Getting to the Heart of the Matter: Direct Reprogramming to Cardiomyocytes (2010) (0)
Abstract 3583: Thymocyte selection-associated HMG box protein (TOX) induces genomic instability in T-cell acute lymphoblastic leukemia (2016) (0)
RNA Regulator of Lipogenesis (RROL) Is a Novel Lncrna Mediating Protein-Protein Interaction at Gene Regulatory Loci Driving Lipogenic Programs in Multiple Myeloma (2020) (0)
A yeast genome expression monitoring database (1999) (0)
Abstract IA01: Transcriptional and epigenetic control of oncogenes (2013) (0)
Abstract PR01: 3D enhancer clusters in the response to Wnt-driven colorectal cancer (2016) (0)
Abstract PR04: Targeting super-enhancer driven oncogene transcription through cyclin-dependent kinase inhibitors (2016) (0)
Erratum: RNA polymerase II subunit RPB10 is essential for yeast cell viability (Journal of Biological Chemistry (1990) 265 (17816-17819)) (1993) (0)
Genome wide chromatin accessibility profiling identifies chromatin signatures and novel transcription factor dependencies in multiple myeloma (2019) (0)
BMP and WNT-Directed Transcription Factors TCF7L2/TCF4 and SMAD1 Bind to Distinct Hematopoietic-Specific Target Genes Depending on Cell Lineage (2010) (0)
Pol II phosphorylation regulates a switch between transcriptional and splicing condensates (2019) (0)
Supplemental Methods PCR analysis on genomic translocations Genomic (2017) (0)
MeCP2 links heterochromatin condensates and neurodevelopmental disease (2020) (0)
Abstract GS3-10: Partitioning of cancer therapeutics in nuclear condensates (2021) (0)
Activation of the LMO2 Oncogene in T-ALL through a Somatically Acquired Neomorphic Promoter (2016) (0)
A gene from mycobacterium tuberculosis which is homologous to the dna j heat shock protein of escherichia coli (1988) (0)
MLX-Centered Transcription Networks Coordination of Nutrient Availability and Utilization by MAX- and (2014) (0)
Stimulation of the Wnt pathway in reprogramming somatic cells (2008) (0)
Simplified ELISA for Detecting Antibodies to Recombinant Fusion Proteins (1999) (0)
Abstract 3230: Genome-wide localization of anti-cancer drugs (2014) (0)
Supporting Online Material for Divergent Transcription from Active Promoters (2008) (0)
Targeting Distinct Promoter- and Enhancer-Driven Dependencies in Multiple Myeloma (2018) (0)
Combinatorial negative regulation of glucose-responsive genes in yeast (1999) (0)
Bioprocessing of MIR17HG Results in Long and Short Noncoding RNAs with Targetable Tumor-Promoting Activity in Multiple Myeloma (2022) (0)
Multivalent gene regulatory elements localize condensation of transcription machinery (2019) (0)
Abstract B121: Oncogenic MYC contributes to tumor super-enhancers via eRNA amplification (2016) (0)
Abstract P5-07-13: Identification of a cancer stem sell-specific function for the histone deacetylases, HDAC1 and HDAC7, in breast and ovarian cancer (2017) (0)
Abstract A166: Biogenesis and regulatory functions of super-enhancer RNAs in cancer cells of the immune system (2016) (0)
Structure and Tissue-Specific Expression of Members of the Mouse α-Amylase Multigene Family (1982) (0)
Nanoformulation and Cancer Therapy: Study of DNA Damage and repair Pathway by Expression and Genome Wide Location Analysis (GWLA) (2007) (0)
The TAL1 Complex Represses the FBXW7 Tumor Suppressor Through Mir-223 in Human T-Cell Acute Lymphoblastic Leukemia (2012) (0)
Lineage regulators and signaling transcription factors during erythropoiesis (2014) (0)
Cloud-Based Real-Time Molecular Screening Platform with MolFormer (2022) (0)
Abstract LB-125: Selective inhibition of CDK7 targets MYCN-driven transcriptional amplification in neuroblastoma (2014) (0)
Abstract 2615: Systematic approaches to predict oncogenic transcriptional regulatory circuitries identify important nodes in high-grade serous ovarian cancer (2019) (0)
BORIS promotes chromatin regulatory interactions in treatment-resistant cancer cells (2019) (0)
Non-overlapping Promoter and Super-enhancer Driven Processes Support Myeloma Cell Growth and Survival via Distinct Regulatory Axes (2017) (0)
Partitioning of cancer therapeutics in nuclear condensates. (2021) (0)
P-119: CDK7 is a proximal regulator of cellular functions impacting MYC-driven pathways and eliciting unique metabolic vulnerabilities in multiple myeloma (2022) (0)
CDK7 Inhibition Targets Proliferative and Metabolic Oncogenic Vulnerabilities in Multiple Myeloma (2022) (0)
Long Noncoding RNA RROL Provides Chromatin Scaffold for MYC-WDR82 Interaction to Impact Lipid Metabolism and Tumor Cell Growth in Multiple Myeloma (2021) (0)
OAB-009: Genome-wide CRISPR interference screen identifies RNA Regulator of Lipogenesis (RROL) as a leading LncRNA dependency in Multiple Myeloma (2021) (0)
Abstract LB216: Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity (2021) (0)
CDK7 controls E2F- and MYC-driven proliferative and metabolic vulnerabilities in multiple myeloma. (2023) (0)
lncRNA DIGIT and BRD3 protein form phase-separated condensates to regulate endoderm differentiation (2020) (0)
The function and structure of the protein-synthesis elongation factors Tu and Ts in phage-Qbeta replicase. (1978) (0)

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