Rik Derynck
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Belgian-American biologist
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Rik Derynck's Degrees
- PhD Molecular Biology Ghent University
- Bachelors Biology Ghent University
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(Suggest an Edit or Addition)Rik Derynck's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Molecular mechanisms of epithelial–mesenchymal transition (2014) (5897)
- Smad-dependent and Smad-independent pathways in TGF-β family signalling (2003) (3766)
- Smad-dependent and Smad-independent pathways in TGF-beta family signalling. (2003) (2882)
- TGF-β-induced epithelial to mesenchymal transition (2009) (2027)
- Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin (1984) (1701)
- Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth (1986) (1681)
- Human transforming growth factor-β complementary DNA sequence and expression in normal and transformed cells (1985) (1667)
- SPECIFICITY AND VERSATILITY IN TGF-β SIGNALING THROUGH SMADS (2005) (1624)
- Transforming growth factor α (1988) (1389)
- TGF-β signaling in tumor suppression and cancer progression (2001) (1336)
- Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor (1995) (1068)
- Evidence that transforming growth factor-β is a hormonally regulated negative growth factor in human breast cancer cells (1987) (1049)
- TGF-beta signaling in tumor suppression and cancer progression. (2001) (1004)
- TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors (1994) (987)
- Specificity and versatility in tgf-beta signaling through Smads. (2005) (939)
- Transcriptional Activators of TGF-β Responses: Smads (1998) (922)
- Synthesis of Messenger RNAs for Transforming Growth Factors α and β and the Epidermal Growth Factor Receptor by Human Tumors (1987) (916)
- Receptor-associated Mad homologues synergize as effectors of the TGF-β response (1996) (844)
- Production and auto-induction of transforming growth factor-α in human keratinocytes (1987) (815)
- Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription (1998) (808)
- Transforming growth factor-alpha: a more potent angiogenic mediator than epidermal growth factor. (1986) (789)
- Guidelines and definitions for research on epithelial–mesenchymal transition (2020) (778)
- Human transforming growth factor-α: Precursor structure and expression in E. coli (1984) (763)
- TGF-&bgr; signaling and epithelial–mesenchymal transition in cancer progression (2013) (710)
- Toward a molecular understanding of skeletal development (1995) (707)
- TGF-β and the TGF-β Family: Context-Dependent Roles in Cell and Tissue Physiology. (2016) (686)
- TGF-β signaling in cancer – a double-edged sword (2001) (651)
- Expression of human immune interferon cDNA in E. coli and monkey cells (1982) (616)
- Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells (2011) (579)
- Smads: transcriptional activators of TGF-beta responses. (1998) (562)
- The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activation. (1998) (551)
- Cell size and invasion in TGF-β–induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway (2007) (542)
- TGF‐β‐induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation (2001) (533)
- Overexpression of transforming growth factor alpha in psoriatic epidermis. (1989) (532)
- Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase. (2001) (518)
- Expression of a Truncated, Kinase-Defective TGF-β Type II Receptor in Mouse Skeletal Tissue Promotes Terminal Chondrocyte Differentiation and Osteoarthritis (1997) (492)
- TGF-beta signaling in cancer--a double-edged sword. (2001) (481)
- The murine transforming growth factor-beta precursor. (1986) (467)
- TGF‐β activates Erk MAP kinase signalling through direct phosphorylation of ShcA (2007) (462)
- Transforming growth factor-beta activation in irradiated murine mammary gland. (1994) (419)
- Inactivation of the type II receptor reveals two receptor pathways for the diverse TGF-beta activities. (1993) (418)
- Macrophage deactivating factor and transforming growth factors-beta 1 -beta 2 and -beta 3 inhibit induction of macrophage nitrogen oxide synthesis by IFN-gamma. (1990) (418)
- Direct transfer of transforming growth factor beta 1 gene into arteries stimulates fibrocellular hyperplasia. (1993) (401)
- Transmembrane TGF-α precursors activate EGF/TGF-α receptors (1989) (388)
- TGF-beta inhibits muscle differentiation through functional repression of myogenic transcription factors by Smad3. (2001) (377)
- Alpha and beta human transforming growth factors stimulate prostaglandin production and bone resorption in cultured mouse calvaria. (1985) (374)
- Cloning of a type I TGF-beta receptor and its effect on TGF-beta binding to the type II receptor. (1993) (370)
- Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15Ink4B transcription in response to TGF‐β (2000) (367)
- Increased expression of TGF-beta 2 in osteoblasts results in an osteoporosis-like phenotype (1996) (365)
- Specificity, versatility, and control of TGF-β family signaling (2019) (359)
- A new type of transforming growth factor‐beta, TGF‐beta 3. (1988) (341)
- Expression in rat fibroblasts of a human transforming growth factor-α cDNA results in transformation (1986) (340)
- The tumor suppressor Smad4/DPC 4 as a central mediator of Smad function (1997) (335)
- Differentiation plasticity regulated by TGF-β family proteins in development and disease (2007) (332)
- Structural analysis of the sequence coding for an inducible 26-kDa protein in human fibroblasts. (1986) (328)
- Transforming Growth Factor-β Inhibits Adipocyte Differentiation by Smad3 Interacting with CCAAT/Enhancer-binding Protein (C/EBP) and Repressing C/EBP Transactivation Function* (2003) (325)
- Repression of Runx2 function by TGF‐β through recruitment of class II histone deacetylases by Smad3 (2005) (324)
- Signaling pathway cooperation in TGF-β-induced epithelial-mesenchymal transition. (2014) (314)
- Roles of Autocrine TGF-β Receptor and Smad Signaling in Adipocyte Differentiation (2000) (305)
- Molecular characterization and chromosomal mapping of melanoma growth stimulatory activity, a growth factor structurally related to beta‐thromboglobulin. (1988) (304)
- New regulatory mechanisms of TGF-beta receptor function. (2009) (301)
- TGF- receptor signaling (1997) (298)
- TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcA. (2007) (292)
- Developmental expression of transforming growth factors alpha and beta in mouse fetus (1988) (281)
- TGFβ biology in cancer progression and immunotherapy (2020) (275)
- Epidermal growth factor receptor function is necessary for normal craniofacial development and palate closure (1999) (269)
- Ectodomain shedding of TGF‐α and other transmembrane proteins is induced by receptor tyrosine kinase activation and MAP kinase signaling cascades (1999) (266)
- Human Transforming Growth Factor- β3: Recombinant Expression, Purification, and Biological Activities in Comparison with Transforming Growth Factors-β 1 and -β2 (1989) (266)
- Receptor-associated Mad homologues synergize as effectors of the TGF-beta response. (1996) (266)
- Cellular interpretation of multiple TGF-beta signals: intracellular antagonism between activin/BVg1 and BMP-2/4 signaling mediated by Smads. (1997) (265)
- The Physiology Of Transforming Growth Factor-α (1992) (261)
- Extracellular matrix regulates expression of the TGF-beta 1 gene (1993) (260)
- Regulation of Smad signalling by protein associations and signalling crosstalk. (1999) (252)
- Isolation and structure of a human fibroblast interferon gene (1980) (250)
- TGF-β-receptor-mediated signaling (1994) (249)
- Direct activation of TACE-mediated ectodomain shedding by p38 MAP kinase regulates EGF receptor-dependent cell proliferation. (2010) (247)
- Regulation of epithelial-mesenchymal and mesenchymal-epithelial transitions by microRNAs. (2013) (247)
- Different transforming growth factor-α species are derived from a glycosylated and palmitoylated transmembrane precursor (1987) (246)
- Differentiation plasticity regulated by TGF-|[beta]| family proteins in development and disease (2007) (240)
- Production of transforming growth factor alpha in human pancreatic cancer cells: evidence for a superagonist autocrine cycle. (1987) (237)
- Murine transforming growth factor-beta 2 cDNA sequence and expression in adult tissues and embryos. (1989) (235)
- Determination of type I receptor specificity by the type II receptors for TGF-beta or activin. (1993) (233)
- The platelet-derived growth factor-inducible KC gene encodes a secretory protein related to platelet alpha-granule proteins. (1989) (231)
- Heteromeric and homomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4 (1997) (225)
- Bone morphogenetic protein and retinoic acid signaling cooperate to induce osteoblast differentiation of preadipocytes (2002) (223)
- Transforming growth factor‐α: Structure and biological activities (1986) (222)
- Osteoblastic Responses to TGF-β during Bone Remodeling (1998) (221)
- Epidermal growth factor and transforming growth factor-alpha: differential intracellular routing and processing of ligand-receptor complexes. (1991) (221)
- TGF-β-induced activation of mTOR complex 2 drives epithelial–mesenchymal transition and cell invasion (2012) (219)
- Transforming growth factor β gene maps to human chromosome 19 long arm and to mouse chromosome 7 (1986) (218)
- Inhibition of TGF-beta receptor signaling in osteoblasts leads to decreased bone remodeling and increased trabecular bone mass. (1999) (217)
- Crystal structure of IRF-3 reveals mechanism of autoinhibition and virus-induced phosphoactivation (2003) (216)
- TGF-beta receptor signaling. (1997) (216)
- Complex regulation of transforming growth factor beta 1, beta 2, and beta 3 mRNA expression in mouse fibroblasts and keratinocytes by transforming growth factors beta 1 and beta 2 (1989) (205)
- Transforming Growth Factor-β Receptors and Smads: Regulatory Complexity and Functional Versatility. (2017) (204)
- A kinase subdomain of transforming growth factor‐β (TGF‐β) type I receptor determines the TGF‐β intracellular signaling specificity (1997) (197)
- Localization of cells synthesizing transforming growth factor-alpha mRNA in the mouse brain (1988) (194)
- TGF-β signaling in tumor suppression and cancer progression (2001) (194)
- Impaired lung branching morphogenesis in the absence of functional EGF receptor. (1997) (194)
- A WD-domain protein that is associated with and phosphorylated by the type II TGF-β receptor (1995) (194)
- Differential regulation of expression of three transforming growth factor beta species in human breast cancer cell lines by estradiol. (1990) (191)
- EMT and Cancer: More Than Meets the Eye. (2019) (190)
- Nomenclature: Vertebrate Mediators of TGFβ Family Signals (1996) (189)
- TGF-beta regulates the mechanical properties and composition of bone matrix. (2005) (185)
- Transforming Growth Factor-ß Signaling in Stem Cells and Cancer (2005) (182)
- Human recombinant transforming growth factor alpha stimulates bone resorption and inhibits formation in vitro. (1986) (179)
- Sumoylation of Smad4, the Common Smad Mediator of Transforming Growth Factor-β Family Signaling* (2003) (177)
- Production and auto-induction of transforming growth factor-alpha in human keratinocytes. (1987) (177)
- Intracellular signalling: The Mad way to do it (1996) (176)
- Expression of human fibroblast interferon gene in Escherichia coli (1980) (175)
- Human transforming growth factor-alpha: precursor structure and expression in E. coli. (1984) (173)
- Synthesis of messenger RNAs for transforming growth factors alpha and beta and the epidermal growth factor receptor by human tumors. (1987) (172)
- Post‐translational regulation of TGF‐β receptor and Smad signaling (2012) (170)
- Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-beta. (2000) (170)
- TGFβ‐stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro‐migratory TGFβ switch (2009) (165)
- Altered metabolic and adhesive properties and increased tumorigenesis associated with increased expression of transforming growth factor beta 1 (1992) (164)
- Vgr-1, a mammalian gene related to Xenopus Vg-1, is a member of the transforming growth factor beta gene superfamily. (1989) (163)
- Human transforming growth factor-alpha stimulates bone resorption in vitro. (1985) (161)
- The Tetraspanin Cd9 Associates with Transmembrane TGF-α and Regulates TGF-α–Induced Egf Receptor Activation and Cell Proliferation (2000) (159)
- Pharmacologic Inhibition of the TGF-β Type I Receptor Kinase Has Anabolic and Anti-Catabolic Effects on Bone (2009) (159)
- Recombinant Vgr-1/BMP-6-expressing tumors induce fibrosis and endochondral bone formation in vivo (1994) (158)
- Transforming Growth Factor-β (TGF-β)-induced Down-regulation of Cyclin A Expression Requires a Functional TGF-β Receptor Complex (1995) (155)
- The primary structure of the Saccharomyces cerevisiae gene for 3-phosphoglycerate kinase. (1982) (153)
- Activation and function of the epidermal growth factor receptor and erbB-2 during mammary gland morphogenesis. (1998) (153)
- Expression of a dominant-negative type II transforming growth factor β (TGF-β) receptor in the epidermis of transgenic mice blocks TGF-β-mediated growth inhibition (1997) (148)
- Abnormal astrocyte development and neuronal death in mice lacking the epidermal growth factor receptor (1998) (147)
- Complementary DNA Cloning of the Murine Transforming Growth Factor-β3 (TGFβ3) Precursor and the Comparative Expression of TGFβ3 and TGFβ1 Messenger RNA in Murine Embryos and Adult Tissues (1989) (146)
- Intron-exon structure of the human transforming growth factor-β precursor gene (1987) (145)
- TGF‐β‐activated Smad3 represses MEF2‐dependent transcription in myogenic differentiation (2004) (143)
- Essential role of TGF-beta signaling in glucose-induced cell hypertrophy. (2009) (143)
- The type I TGF-β receptor is covalently modified and regulated by sumoylation (2008) (139)
- The Type II Transforming Growth Factor-β Receptor Autophosphorylates Not Only on Serine and Threonine but Also on Tyrosine Residues* (1997) (138)
- Expression and secretion of gro/MGSA by stimulated human endothelial cells. (1989) (138)
- TACE Activation by MAPK-Mediated Regulation of Cell Surface Dimerization and TIMP3 Association (2012) (137)
- TGF-β family signaling in stem cells. (2013) (135)
- Homomeric interactions between type II transforming growth factor-beta receptors. (1994) (134)
- The Type II Transforming Growth Factor (TGF)-β Receptor-interacting Protein TRIP-1 Acts as a Modulator of the TGF-β Response* (1998) (133)
- Dominant-negative interference of the transforming growth factor beta type II receptor in mammary gland epithelium results in alveolar hyperplasia and differentiation in virgin mice. (1998) (133)
- Characterization of Growth Factor-induced Serine Phosphorylation of Tumor Necrosis Factor-α Converting Enzyme and of an Alternatively Translated Polypeptide* (2003) (131)
- Modulation of expression and cell surface binding of members of the transforming growth factor-beta superfamily during retinoic acid-induced osteoblastic differentiation of multipotential mesenchymal cells. (1993) (131)
- Increased transforming growth factor beta expression inhibits cell proliferation in vitro, yet increases tumorigenicity and tumor growth of Meth A sarcoma cells. (1993) (130)
- Chronic TGF-β exposure drives stabilized EMT, tumor stemness, and cancer drug resistance with vulnerability to bitopic mTOR inhibition (2019) (129)
- Induction of transforming growth factor-alpha expression in human keratinocytes by phorbol esters. (1989) (128)
- The Discovery and Early Days of TGF-β: A Historical Perspective. (2016) (127)
- Transcriptional Regulation of the Transforming Growth Factor-β-inducible Mouse Germ Line Ig α Constant Region Gene by Functional Cooperation of Smad, CREB, and AML Family Members* (2000) (125)
- Physical and Functional Interactions between Type I Transforming Growth Factor β Receptors and Bα, a WD-40 Repeat Subunit of Phosphatase 2A (1998) (125)
- Inhibition of translation of transforming growth factor-beta 3 mRNA by its 5' untranslated region (1991) (122)
- Ligand-independent Activation of Transforming Growth Factor (TGF) β Signaling Pathways by Heteromeric Cytoplasmic Domains of TGF-β Receptors* (1996) (121)
- Recombinant human transforming growth factor-alpha stimulates the formation of osteoclast-like cells in long-term human marrow cultures. (1986) (121)
- Crystal structure of IRF-3 in complex with CBP. (2005) (119)
- The TGF-β Family (2008) (117)
- Loss of growth responsiveness to epidermal growth factor and enhanced production of alpha‐transforming growth factors in ras‐transformed mouse mammary epithelial cells (1987) (115)
- Expression of transforming growth factor alpha (TGF alpha) in differentiated rat mammary tumors: estrogen induction of TGF alpha production. (1987) (115)
- Fibroblast-specific inhibition of TGF-β1 signaling attenuates lung and tumor fibrosis. (2017) (115)
- TACE-mediated ectodomain shedding of the type I TGF-beta receptor downregulates TGF-beta signaling. (2009) (114)
- Effects of MGSA/GRO alpha on melanocyte transformation. (1991) (111)
- Secretory proteins induced in human fibroblasts under conditions used for the production of interferon beta. (1982) (110)
- TGFβ family signaling: novel insights in development and disease (2009) (110)
- Transmembrane transforming growth factor‐α tethers to the PDZ domain‐containing, Golgi membrane‐associated protein p59/GRASP55 (2000) (107)
- Structural and Functional Characterization of the Transforming Growth Factor-β-induced Smad3/c-Jun Transcriptional Cooperativity* (2000) (107)
- Multiple trophic actions of heparin‐binding epidermal growth factor (HB‐EGF) in the central nervous system (1999) (103)
- Arginine Methylation Initiates BMP-Induced Smad Signaling. (2013) (95)
- Repression of Bone Morphogenetic Protein and Activin-inducible Transcription by Evi-1* (2005) (95)
- Smad7 Is Induced by CD40 and Protects WEHI 231 B-lymphocytes from Transforming Growth Factor-β-induced Growth Inhibition and Apoptosis* (2000) (92)
- The murine type II TGF-beta receptor has a coincident embryonic expression and binding preference for TGF-beta 1. (1994) (91)
- Autonomous growth of human keratinocytes requires epidermal growth factor receptor occupancy. (1993) (91)
- Emergence of the Phosphoinositide 3-Kinase-Akt- Mammalian Target of Rapamycin Axis in Transforming Growth Factor-β-Induced Epithelial-Mesenchymal Transition (2010) (91)
- Medicine: Interfering with bone remodelling (2002) (90)
- Smad2 Is Essential for Maintenance of the Human and Mouse Primed Pluripotent Stem Cell State* (2013) (88)
- Vgr-1/BMP-6 induces osteoblastic differentiation of pluripotential mesenchymal cells. (1995) (87)
- Actions of growth factors on plasma calcium. Epidermal growth factor and human transforming growth factor-alpha cause elevation of plasma calcium in mice. (1986) (86)
- TGF-β-induced activation of mTOR complex 2 drives epithelial–mesenchymal transition and cell invasion (2012) (86)
- Inhibition of myogenic differentiation in myoblasts expressing a truncated type II TGF-beta receptor. (1994) (86)
- Chromosomal mapping of genes for transforming growth factors beta 2 and beta 3 in man and mouse: dispersion of TGF-beta gene family. (1988) (86)
- Transforming Growth Factor‐β: A Family of Growth Regulatory Peptides (1990) (85)
- Human transforming growth factor-α causes precocious eyelid opening in newborn mice (1985) (84)
- Phosphorylation-dependent Interaction of the Cytoplasmic Domains of the Type I and Type II Transforming Growth Factor- Receptors (*) (1995) (83)
- Osteoblastic responses to TGF-beta during bone remodeling. (1998) (81)
- Distinct vascular actions of epidermal growth factor-urogastrone and transforming growth factor-alpha. (1987) (81)
- 2 TGF-β and the TGF-β Family (2008) (81)
- Association of the transmembrane TGF-alpha precursor with a protein kinase complex (1994) (81)
- Transformation of an established mouse mammary epithelial cell line following transfection with a human transforming growth factor alpha cDNA (1989) (80)
- TGF-beta-receptor-mediated signaling. (1994) (80)
- Differential utilization and localization of ErbB receptor tyrosine kinases in skin compared to normal and malignant keratinocytes. (2001) (80)
- Human transforming growth factor-beta 3: recombinant expression, purification, and biological activities in comparison with transforming growth factors-beta 1 and -beta 2. (1989) (77)
- The human transforming growth factor alpha promoter directs transcription initiation from a single site in the absence of a TATA sequence (1988) (75)
- TGFα stimulates growth of skin papillomas by autocrine and paracrine mechanisms but does not cause neoplastic progression (1988) (74)
- Transmembrane TGF-alpha precursors activate EGF/TGF-alpha receptors. (1989) (74)
- Transforming Growth Factor-β Inhibits Pulmonary Surfactant Protein B Gene Transcription through SMAD3 Interactions with NKX2.1 and HNF-3 Transcription Factors* (2002) (74)
- Nomenclature: vertebrate mediators of TGFbeta family signals. (1996) (73)
- Bone remodelling: A signalling system for osteoclast regulation (1998) (70)
- The human transforming growth factor type alpha coding sequence is not a direct-acting oncogene when overexpressed in NIH 3T3 cells. (1987) (69)
- Evidence for a unique human fibroblast interferon (IFN-beta 1) chromosomal gene, devoid of intervening sequences. (1981) (69)
- Cysteines 153 and 154 of Transmembrane Transforming Growth Factor-α Are Palmitoylated and Mediate Cytoplasmic Protein Association* (1996) (69)
- Sequence of the porcine transforming growth factor-beta precursor. (1987) (67)
- Stem cell antigen-1 enhances tumorigenicity by disruption of growth differentiation factor-10 (GDF10)–dependent TGF-β signaling (2011) (66)
- A kinase subdomain of transforming growth factor-beta (TGF-beta) type I receptor determines the TGF-beta intracellular signaling specificity. (1997) (64)
- Transforming Growth Factor β/Smad3 Signaling Regulates IRF-7 Function and Transcriptional Activation of the Beta Interferon Promoter (2004) (64)
- Dominant negative mutants of transforming growth factor-beta 1 inhibit the secretion of different transforming growth factor-beta isoforms (1992) (64)
- Innate antiviral host defense attenuates TGF-β function through IRF3-mediated suppression of Smad signaling. (2014) (62)
- The physiology of transforming growth factor-alpha. (1992) (61)
- Identification of partners of TIF34, a component of the yeast eIF3 complex, required for cell proliferation and translation initiation (1997) (58)
- Inhibition of parathyroid hormone-responsive adenylate cyclase in clonal osteoblast-like cells by transforming growth factor alpha and epidermal growth factor. (1987) (56)
- Expression of the human interferon–γ cDNA in yeast (1983) (55)
- Transcriptional regulation of the transforming growth factor-beta -inducible mouse germ line Ig alpha constant region gene by functional cooperation of Smad, CREB, and AML family members. (2000) (54)
- Cornichon regulates transport and secretion of TGFα-related proteins in metazoan cells (2007) (52)
- Arginine methylation of SMAD7 by PRMT1 in TGF-β–induced epithelial–mesenchymal transition and epithelial stem-cell generation (2018) (52)
- Repression of Runx 2 function by TGF-b through recruitment of class II histone deacetylases by Smad 3 (2005) (51)
- Uterine and vaginal organ growth requires epidermal growth factor receptor signaling from stroma. (1998) (51)
- The insulin response integrates increased TGF-β signaling through Akt-induced enhancement of cell surface delivery of TGF-β receptors (2015) (51)
- Molecular mechanisms of nucleotide-sequence rearrangements in cDNA clones of human fibroblast interferon mRNA. (1981) (51)
- Uterine and Vaginal Organ Growth Requires Epidermal Growth Factor Receptor Signaling from Stroma. (1998) (50)
- TGF-beta family signaling in mesenchymal differentiation (2007) (50)
- Nucleotide sequence of the chromosomal gene for human fibroblast (beta 1) interferon and of the flanking regions. (1981) (50)
- Mapping of transforming growth factor alpha gene on human chromosome 2 close to the breakpoint of the Burkitt's lymphoma t(2;8) variant translocation. (1985) (48)
- Expression of a dominant-negative type II transforming growth factor beta (TGF-beta) receptor in the epidermis of transgenic mice blocks TGF-beta-mediated growth inhibition. (1997) (47)
- Transforming growth factor-beta (TGF-beta)-induced down-regulation of cyclin A expression requires a functional TGF-beta receptor complex. Characterization of chimeric and truncated type I and type II receptors. (1995) (47)
- Epithelial plasticity, epithelial-mesenchymal transition, and the TGF-β family. (2021) (46)
- Characterization of a human Rhomboid homolog, p100hRho/RHBDF1, which interacts with TGF‐α family ligands (2005) (46)
- Identification of the GATA Factor TRPS1 as a Repressor of the Osteocalcin Promoter* (2009) (45)
- TGF-regulates the mechanical properties and composition of bone matrix (2005) (41)
- Intron-exon structure of the human transforming growth factor-beta precursor gene. (1987) (41)
- Meeting Report: Signaling Schemes for TGF-β (2001) (41)
- Smad3‐mediated recruitment of the methyltransferase SETDB1/ESET controls Snail1 expression and epithelial–mesenchymal transition (2018) (41)
- Association of tetraspanin CD9 with transmembrane TGFα confers alterations in cell-surface presentation of TGFα and cytoskeletal organization (2008) (40)
- Physical and functional interactions between type I transforming growth factor beta receptors and Balpha, a WD-40 repeat subunit of phosphatase 2A. (1998) (40)
- TGF‐β as a driver of fibrosis: physiological roles and therapeutic opportunities (2021) (39)
- ShcA Protects against Epithelial–Mesenchymal Transition through Compartmentalized Inhibition of TGF-β-Induced Smad Activation (2015) (39)
- TACE-Mediated Ectodomain Shedding of the Type I TGF-b Receptor Downregulates TGF-b Signaling (2009) (37)
- Tissue‐specific calibration of extracellular matrix material properties by transforming growth factor‐β and Runx2 in bone is required for hearing (2010) (36)
- Transforming growth factor-alpha: structure and biological activities. (1986) (36)
- Autotaxin-mediated lipid signaling intersects with LIF and BMP signaling to promote the naive pluripotency transcription factor program (2016) (35)
- TGF- and the TGF- Family (2008) (34)
- Differential Binding of Transforming Growth Factor-β1, -β2, and -β3 by Fibroblasts and Epithelial Cells Measured by Affinity Cross-Linking of Cell Surface Receptors (1991) (33)
- Developmental biology: SMAD proteins and mammalian anatomy (1998) (32)
- Transforming growth factor–β (TGF-β)–induced up-regulation of TGF-β receptors at the cell surface amplifies the TGF-β response (2019) (32)
- Human Interferon γ is encoded by a single class of mRNA (1982) (32)
- Complementary DNA cloning of the murine transforming growth factor-beta 3 (TGF beta 3) precursor and the comparative expression of TGF beta 3 and TGF beta 1 messenger RNA in murine embryos and adult tissues. (1989) (30)
- Oncogene and tumour suppressor: the two faces of SnoN (2009) (23)
- Differential Gene Expression between Juvenile and Adult Dura Mater: A Window into What Genes Play a Role in the Regeneration of Membranous Bone (2006) (23)
- E7 proteins from high- and low-risk human papillomaviruses bind to TGF-β-regulated Smad proteins and inhibit their transcriptional activity (2006) (22)
- 22 TGF-β Family Signaling in Skeletal Development, Maintenance, and Disease (2007) (22)
- Human transforming growth factor-alpha causes precocious eyelid opening in newborn mice. (1985) (21)
- Meeting report: signaling schemes for TGF-beta. (2001) (20)
- TGF b-stimulated Smad 1 / 5 phosphorylation requires the ALK 5 L 45 loop and mediates the pro-migratory TGF b switch (2009) (19)
- Enhanced TGF-β Signaling Contributes to the Insulin-Induced Angiogenic Responses of Endothelial Cells (2019) (18)
- Regulation of TGF-β Receptors. (2016) (16)
- Transforming growth factor-beta. A family of growth regulatory peptides. (1990) (15)
- Integration of TGF-β-induced Smad signaling in the insulin-induced transcriptional response in endothelial cells (2019) (14)
- Induction of myogenesis in mesenchymal cells by MyoD depends on their degree of differentiation. (1996) (14)
- Generation of antibodies and assays for transforming growth factor alpha. (1991) (13)
- Expression of the human interferon-gamma cDNA in yeast. (1983) (13)
- Human interferon gamma is encoded by a single class of mRNA. (1982) (12)
- BMP-9 balances endothelial cell fate (2013) (11)
- JNK Regulates Expression and Autocrine Signaling of TGF-β1 (2004) (11)
- TGF-Bèta family signaling in skeletal development, maintenance, and disease. (2007) (11)
- Differential binding of transforming growth factor-beta 1, -beta 2, and -beta 3 by fibroblasts and epithelial cells measured by affinity cross-linking of cell surface receptors. (1991) (11)
- A two-dimensional electrophoretic procedure for the separation of DNA restriction fragments. (1977) (11)
- Complex Regulation of Transforming Growth Factor 13, 12, and 13 mRNA Expression in Mouse Fibroblasts and Keratinocytes by Transforming Growth Factors 13 and 12 (2003) (10)
- Virtual screening for small molecule pathway regulators by image profile matching (2021) (9)
- Association of the Transmembrane TGF-tx Precursor with a Protein Kinase Complex (1994) (8)
- An emerging complexity of receptors for transforming growth factor-beta. (1994) (8)
- Author Correction: Guidelines and definitions for research on epithelial–mesenchymal transition (2021) (7)
- Mammalian Two-Hybrid Assays (2001) (7)
- Pillars Article: production of transforming growth factor β by human T lymphocytes and its potential role in the regulation of T cell growth. J Exp Med. 1986. 163: 1037-1050. (2014) (6)
- PLASMID-DIRECTED SYNTHESIS OF HUMAN IMMUNE INTERFERON IN E. COLI AND MONKEY CELLS (1982) (6)
- Does Smad6 methylation control BMP signaling in cancer? (2014) (6)
- JNK regulates expression and autocrine signaling of TGF-beta1. (2004) (6)
- Erratum: Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TFG-β-induced transcription (1998) (5)
- Endogenous and heterologous expression of transforming growth factor-alpha in mammalian cells. (1986) (5)
- In vitro cotranslational processing of human pre-interferon beta 1 enhances its biological activity. (1982) (4)
- Growth regulation by transforming growth factor-β (1993) (4)
- Transforming growth factors-α and -β and their potential roles in neoplastic transformation (1989) (4)
- Purification and characterization of recombinant melanoma growth stimulating activity. (1991) (4)
- Mammalian two-hybrid assays. Analyzing protein-protein interactions in transforming growth factor-beta signaling pathway. (2001) (3)
- Structure and sequence of the mouse bmp6 gene (1997) (3)
- Isolation and characterization of a human fibroblast interferon gene and its expression in Escherichia coli. (1981) (3)
- Two dimensional electrophoretic separation of restriction fragments. (1977) (3)
- Webinar | Key signaling pathways in cancer: Links to developmental biology (2016) (2)
- Transforming growth factor-alpha. (1990) (2)
- Smads In Mesenchymal Differentiation (2006) (1)
- Transforming growth factors-alpha and -beta and their potential roles in neoplastic transformation. (1989) (1)
- 4742003 Human transforming growth factor (1989) (1)
- Expression of Human Interferon-γ in Heterologous Systems Genentech, Inc. Contribution no. 134. (1983) (1)
- The human fibroblast interferon gene(s) and their expression in heterologous cells. (1982) (1)
- Direct transfer of transforming growth factor j81 gene into arteries stimulates fibrocellular hyperplasia (gene transfer/gene expression/extraceliular matrix/ceilular proliferation) (2005) (1)
- SYNTHESIS OF HUMAN INTERFERONS AND ANALOGS IN HETEROLOGOUS CELLS (1982) (1)
- Growth regulation by transforming growth factor-beta. (1992) (1)
- Guidelines and definitions for research on epithelial–mesenchymal transition (2020) (1)
- Integration of TGF-β-induced Smad signaling in the insulin-induced transcriptional response in endothelial cells (2019) (0)
- Encouraging education and outreach initiatives (1998) (0)
- Abstract 323: Arginine Methylation Regulates Epicardial Cell Plasticity (2013) (0)
- Transforming growth factor-β (TGF-β) is a group of multi- functional regulatory polypeptides that are secreted by a large variety of cells and play a crucial role in cell proliferation, differentiation, migration and extracellular matrix production (1993) (0)
- S-1: Complexity of cytokines in Treg function and stability (2013) (0)
- 578 High Content Analysis of the Epithelial-Mesenchymal Transition to Identify Novel Targets in Cancer Progression (2012) (0)
- Analysis of recombinant gene expression and function in arteries following direct gene transfer (1994) (0)
- Cell differentiation. (1997) (0)
- VGR-1/BMP-6 INDUCES OSTEOGENIC DIFFERENTIATION IN MESEN-CHYMAL CELLS (1993) (0)
- A process for the production of TGF-beta, DNA and mRNA coding for TGF-beta, as well as replicable vectors comprising the DNA and host cells containing the vectors (1986) (0)
- Human transforming growth factor and precursor or fragment thereof, cells, DNA, vectors and methods for their preparation, compositions and products containing them, and antibodies derived therefrom and diagnostic methods. (1985) (0)
- a and f 3 human transforming growth factors stimulate prostaglandin production and bone resorption in cultured mouse calvaria ( bone resorption / prostaglandin E 2 ) (0)
- Preface/Front Matter (2008) (0)
- Human Tumors and the Epidermal Growth Factor Receptor by β and α Factors Synthesis of Messenger RNAs for Transforming Growth (2006) (0)
- Signalling by TGF-β (2005) (0)
- The TGB-β family in endothelial cell differentiation and cardiovascular development and function (2008) (0)
- Expression of Concern: Association of tetraspanin CD9 with transmembrane TGFα confers alterations in cell-surface presentation of TGFα and cytoskeletal organization. (2022) (0)
- Reviewer list for 1995 (1995) (0)
- テトラスパンニンCD9は膜貫通型TGF‐αと結合し,TGF‐α誘導性のEGF受容体活性化と細胞増殖を調節する (2000) (0)
- Results Expression of FuU-Length and Truncated TGFc ~ Precursors in CHO Cells (2002) (0)
- EXPRESSION OF HUMAN FIBROBLAST AND HUMAN IMMUNE INTERFERON GENES IN HOMOLOGOUS AND HETEROLOGOUS CELLS (1982) (0)
- DENTISTRY FACULTY COUNCIL Deborah Greenspan, DSc, BDS, Chair (2002) (0)
- Biochemical reagents on tap (1998) (0)
- Skeletal development in the zebrafish (1999) (0)
- Recombinant HumanTransforming GrowthFactor-Alpha Stimulates the Formation ofOsteoclast-like Cells inLong-term HumanMarrowCultures (1986) (0)
- BONE TURNOVER AND MECHANICAL PROPERTIES FOLLOWING ONE YEAR TREATMENT WITH ANTI- REMODELING AGENTS IN SKELETALLY-MATURE BEAGLES (2006) (0)
- Abstract IA31: Control of TGF-β responsiveness and epithelial plasticity (2016) (0)
- Poster abstracts from the 36 th Meeting of the International Sun Valley Workshop on Skeletal Tissue Biology (2006) (0)
- Cells and Cancer Transforming Growth Factor-ß Signaling in Stem (2010) (0)
- TGF- β as a driver of fi brosis: physiological roles and therapeutic opportunities (2021) (0)
- Stem cell antigen‐1 (Sca‐1) disrupts GDF10/TGF‐β signal transduction at the plasma membrane to regulate Smad2/3 nuclear signaling (2011) (0)
- THE ROLE OF TGF-β FAMILY MEMBERS IN MESENCHYMAL DIFFERENTIATION (1993) (0)
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