Rita Bernhardt
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Rita Bernhardt's Degrees
- Masters Artificial Intelligence Stanford University
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(Suggest an Edit or Addition)Rita Bernhardt's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Cytochrome P450 (1993) (1119)
- Cytochromes P450 as versatile biocatalysts. (2006) (763)
- Cytochrome P450 systems--biological variations of electron transport chains. (2007) (667)
- Cytochromes P450 as promising catalysts for biotechnological application: chances and limitations (2014) (266)
- Humans possess two mitochondrial ferredoxins, Fdx1 and Fdx2, with distinct roles in steroidogenesis, heme, and Fe/S cluster biosynthesis (2010) (246)
- Cytochrome P450: structure, function, and generation of reactive oxygen species. (1996) (198)
- Influence of grain germination on functional properties of sorghum flour (2010) (180)
- Selected Physicochemical Properties of Starch Isolated from Fermented Sorghum Flour (2004) (177)
- Adrenodoxin: Structure, stability, and electron transfer properties (2000) (172)
- Effect of fermentation on the functional properties of sorghum flour (2005) (161)
- New aspects of electron transfer revealed by the crystal structure of a truncated bovine adrenodoxin, Adx(4-108). (1998) (119)
- Functional expression of human mitochondrial CYP11B2 in fission yeast and identification of a new internal electron transfer protein, etp1. (2002) (97)
- Dynamics in a pure encounter complex of two proteins studied by solution scattering and paramagnetic NMR spectroscopy. (2008) (97)
- Modulation of aldosterone and cortisol synthesis on the molecular level (2004) (96)
- C-terminal region of adrenodoxin affects its structural integrity and determines differences in its electron transfer function to cytochrome P-450. (1994) (95)
- Expression of bovine adrenodoxin in E. coli and site-directed mutagenesis of /2 Fe-2S/ cluster ligands. (1992) (94)
- Characterization of the versatile monooxygenase CYP109B1 from Bacillus subtilis (2010) (94)
- CYP17- and CYP11B-dependent steroid hydroxylases as drug development targets. (2006) (90)
- The Human Steroid Hydroxylases CYP11B1 and CYP11B2 (2002) (86)
- Vitamin D3 Metabolism in Human Glioblastoma Multiforme: Functionality of CYP27B1 Splice Variants, Metabolism of Calcidiol, and Effect of Calcitriol (2005) (83)
- Differential regulation of 11β-hydroxylase and aldosterone synthase in human adrenocortical H295R cells (1996) (83)
- Towards Preparative Scale Steroid Hydroxylation with Cytochrome P450 Monooxygenase CYP106A2 (2010) (82)
- Cellular surface display of dimeric Adx and whole cell P450-mediated steroid synthesis on E. coli. (2002) (79)
- Adrenodoxin: the archetype of vertebrate-type [2Fe-2S] cluster ferredoxins. (2011) (77)
- Development of a test system for inhibitors of human aldosterone synthase (CYP11B2): screening in fission yeast and evaluation of selectivity in V79 cells (2002) (77)
- Transient protein interactions studied by NMR spectroscopy: the case of cytochrome C and adrenodoxin. (2003) (76)
- Cloning of CYP11B1 and CYP11B2 from normal human adrenal and their functional expression in COS-7 and V79 Chinese hamster cells. (1995) (69)
- Selective chemical modification of a functionally linked lysine in cytochrome P-450 LM2. (1984) (67)
- The role of sulfated steroid hormones in reproductive processes (2017) (64)
- Structural and Functional Analysis of Novel Human Cytochrome c Targets in Apoptosis* (2014) (64)
- Functional Display of Active Bovine Adrenodoxin on the Surface of E. coli by Chemical Incorporation of the [2Fe–2S] Cluster (2001) (64)
- A solution model of the complex formed by adrenodoxin and adrenodoxin reductase determined by paramagnetic NMR spectroscopy. (2010) (62)
- Unequal crossing-over between aldosterone synthase and 11beta-hydroxylase genes causes congenital adrenal hyperplasia. (2001) (61)
- Design of an Escherichia coli system for whole cell mediated steroid synthesis and molecular evolution of steroid hydroxylases. (2006) (61)
- Efficient conversion of 11-deoxycortisol to cortisol (hydrocortisone) by recombinant fission yeast Schizosaccharomyces pombe. (2005) (60)
- Conferring aldosterone synthesis to human CYP11B1 by replacing key amino acid residues with CYP11B2-specific ones. (1998) (60)
- Modelling of three-dimensional structures of cytochromes P450 11B1 and 11B2. (2001) (59)
- Synthesis and evaluation of imidazolylmethylenetetrahydronaphthalenes and imidazolylmethyleneindanes: potent inhibitors of aldosterone synthase. (2005) (58)
- A new Bacillus megaterium whole-cell catalyst for the hydroxylation of the pentacyclic triterpene 11-keto-β-boswellic acid (KBA) based on a recombinant cytochrome P450 system (2012) (57)
- Identification of CYP106A2 as a Regioselective Allylic Bacterial Diterpene Hydroxylase (2011) (57)
- Substrate binding to 15beta-hydroxylase (CYP106A2) probed by FT infrared spectroscopic studies of the iron ligand CO stretch vibration. (2000) (57)
- Modification of cytochrome P-450 with fluorescein isothiocyanate. (1983) (56)
- Regioselective hydroxylation of norisoprenoids by CYP109D1 from Sorangium cellulosum So ce56 (2010) (56)
- New Arabidopsis thaliana Cytochrome c Partners: A Look Into the Elusive Role of Cytochrome c in Programmed Cell Death in Plants* (2013) (56)
- A new electron transport mechanism in mitochondrial steroid hydroxylase systems based on structural changes upon the reduction of adrenodoxin. (2002) (54)
- Discovery of a steroid 11α-hydroxylase from Rhizopus oryzae and its biotechnological application. (2010) (54)
- Redox Partners: Function Modulators of Bacterial P450 Enzymes. (2020) (53)
- The CYP11B subfamily (2015) (50)
- Application of a new versatile electron transfer system for cytochrome P450-based Escherichia coli whole-cell bioconversions (2013) (50)
- The CYPome of Sorangium cellulosum So ce56 and identification of CYP109D1 as a new fatty acid hydroxylase. (2010) (50)
- Two forms of omega-hydroxylase toward prostaglandin A and laurate. cDNA cloning and their expression. (1989) (50)
- Fermentation modifies protein/protein and protein/starch interactions in sorghum dough (2006) (49)
- Purification and functional characterization of human 11β hydroxylase expressed in Escherichia coli (2008) (49)
- Intermolecular dynamics studied by paramagnetic tagging (2009) (48)
- Inhibition of Cytochromes P450: Existing and New Promising Therapeutic Targets (2007) (48)
- Mutations of tyrosine 82 in bovine adrenodoxin that affect binding to cytochromes P45011A1 and P45011B1 but not electron transfer. (1994) (48)
- Bacterial steroid hydroxylases: enzyme classes, their functions and comparison of their catalytic mechanisms (2018) (48)
- Terpene hydroxylation with microbial cytochrome P450 monooxygenases. (2015) (48)
- Engineering a Mineralocorticoid- to a Glucocorticoid-synthesizing Cytochrome P450 (*) (1996) (47)
- Adrenodoxin—A versatile ferredoxin (2012) (47)
- Steroid Hydroxylation: Microbial Steroid Biotransformations Using Cytochrome P450 Enzymes (2007) (47)
- Identification of monohydroxy progesterones produced by CYP106A2 using comparative HPLC and electrospray ionisation collision-induced dissociation mass spectrometry. (2004) (46)
- Changing the Regioselectivity of a P450 from C15 to C11 Hydroxylation of Progesterone (2012) (45)
- Structural basis of steroid binding and oxidation by the cytochrome P450 CYP109E1 from Bacillus megaterium (2016) (45)
- Amino acid substitution R384P in aldosterone synthase causes corticosterone methyloxidase type I deficiency. (1995) (43)
- Genome Mining in Sorangium cellulosum So ce56 (2009) (43)
- Molecular Evolution of a Steroid Hydroxylating Cytochrome P450 Using a Versatile Steroid Detection System for Screening (2008) (43)
- The Interaction of Bovine Adrenodoxin with CYP11A1 (Cytochrome P450scc) and CYP11B1 (Cytochrome P45011β) (2001) (43)
- The Role of Threonine 54 in Adrenodoxin for the Properties of Its Iron-Sulfur Cluster and Its Electron Transfer Function (*) (1995) (43)
- Analyses of the CYP11B gene family in the guinea pig suggest the existence of a primordial CYP11B gene with aldosterone synthase activity. (2002) (43)
- Human aldosterone synthase: Recombinant expression in E. coli and purification enables a detailed biochemical analysis of the protein on the molecular level (2012) (43)
- Coexpression of redox partners increases the hydrocortisone (cortisol) production efficiency in CYP11B1 expressing fission yeast Schizosaccharomyces pombe. (2008) (42)
- Cytochrome P450 and Steroid Hormone Biosynthesis (2007) (42)
- Cloning and stable expression of the human mitochondrial cytochrome P45011B1 cDNA in V79 Chinese hamster cells and their application for testing of potential inhibitors. (1995) (42)
- The adrenodoxin-like ferredoxin of Schizosaccharomyces pombe mitochondria. (2004) (41)
- A steroidogenic pathway for sulfonated steroids: The metabolism of pregnenolone sulfate (2014) (40)
- Steroid conversion with CYP106A2 – production of pharmaceutically interesting DHEA metabolites (2014) (40)
- Transforming growth factor beta1 inhibits aldosterone and cortisol production in the human adrenocortical cell line NCI-H295R through inhibition of CYP11B1 and CYP11B2 expression. (2003) (40)
- Electrostatic interactions between cytochrome P-450 LM2 and NADPH-cytochrome P-450 reductase. (1988) (38)
- Hemin rescues adrenodoxin, heme a and cytochrome oxidase activity in frataxin-deficient oligodendroglioma cells. (2007) (38)
- Specific Aspects of Electron Transfer from Adrenodoxin to Cytochromes P450scc and P45011β* (1997) (38)
- Role of steroid sulfatase in steroid homeostasis and characterization of the sulfated steroid pathway: Evidence from steroid sulfatase deficiency (2016) (38)
- Characterization of the Gene Cluster CYP264B1‐geoA from Sorangium cellulosum So ce56: Biosynthesis of (+)‐Eremophilene and Its Hydroxylation (2015) (38)
- Design and characterization of an efficient CYP105A1-based whole-cell biocatalyst for the conversion of resin acid diterpenoids in permeabilized Escherichia coli (2013) (37)
- A new cytochrome P450 system from Bacillus megaterium DSM319 for the hydroxylation of 11-keto-β-boswellic acid (KBA) (2014) (37)
- Development of test systems for the discovery of selective human aldosterone synthase (CYP11B2) and 11β-hydroxylase (CYP11B1) inhibitors. Discovery of a new lead compound for the therapy of congestive heart failure, myocardial fibrosis and hypertension (2004) (37)
- Theoretical and Experimental Evaluation of a CYP106A2 Low Homology Model and Production of Mutants with Changed Activity and Selectivity of Hydroxylation (2008) (37)
- Function and engineering of the 15β-hydroxylase CYP106A2 (2006) (36)
- Autodisplay of functional CYP106A2 in Escherichia coli. (2012) (36)
- Stripping Down the Mitochondrial Cholesterol Hydroxylase System, a Kinetics Study* (2004) (35)
- The Loop Region Covering the Iron-Sulfur Cluster in Bovine Adrenodoxin Comprises a New Interaction Site for Redox Partners* (2001) (35)
- Vertebrate-type and plant-type ferredoxins: crystal structure comparison and electron transfer pathway modelling. (1999) (34)
- Hydroxylation of the triterpenoid dipterocarpol with CYP106A2 from Bacillus megaterium (2012) (33)
- Dehydroepiandrosterone Sulfate (DHEAS) Stimulates the First Step in the Biosynthesis of Steroid Hormones (2014) (33)
- Deletions in the loop surrounding the iron-sulfur cluster of adrenodoxin severely affect the interactions with its native redox partners adrenodoxin reductase and cytochrome P450(scc) (CYP11A1). (2002) (31)
- Human adrenal CYP11B1: localization by in situ-hybridization and functional expression in cell cultures. (1995) (31)
- The endogenous adrenodoxin reductase-like flavoprotein arh1 supports heterologous cytochrome P450-dependent substrate conversions in Schizosaccharomyces pombe. (2008) (31)
- A recombinant CYP11B1 dependent Escherichia coli biocatalyst for selective cortisol production and optimization towards a preparative scale (2015) (31)
- Comparison of CYP106A1 and CYP106A2 from Bacillus megaterium – identification of a novel 11-oxidase activity (2015) (31)
- Effects of 18-hydroxylated steroids on corticosteroid production by human aldosterone synthase and 11beta-hydroxylase. (2001) (30)
- CYP264B1 from Sorangium cellulosum So ce56: a fascinating norisoprenoid and sesquiterpene hydroxylase (2012) (30)
- Atomic Force Microscopy Study of Protein–Protein Interactions in the Cytochrome CYP11A1 (P450scc)-Containing Steroid Hydroxylase System (2010) (30)
- CYP17A1 inhibitor abiraterone, an anti-prostate cancer drug, also inhibits the 21-hydroxylase activity of CYP21A2 (2017) (30)
- Resin Acid Conversion with CYP105A1: An Enzyme with Potential for the Production of Pharmaceutically Relevant Diterpenoids (2013) (29)
- Unfolding and conformational studies on bovine adrenodoxin probed by engineered intrinsic tryptophan fluorescence. (2002) (29)
- Process development for the production of 15β-hydroxycyproterone acetate using Bacillus megaterium expressing CYP106A2 as whole-cell biocatalyst (2015) (28)
- Novel family members of CYP109 from Sorangium cellulosum So ce56 exhibit characteristic biochemical and biophysical properties (2013) (28)
- Engineering of versatile redox partner fusions that support monooxygenase activity of functionally diverse cytochrome P450s (2017) (28)
- Carboetomidate: An Analog of Etomidate That Interacts Weakly with 11&bgr;-Hydroxylase (2013) (28)
- The effect of amino-acid substitutions I112P, D147E and K152N in CYP11B2 on the catalytic activities of the enzyme. (2002) (27)
- Modulation of aldosterone biosynthesis by adrenodoxin mutants with different electron transport efficiencies. (1999) (27)
- Drug Interaction Potential of 2-((3,4-Dichlorophenethyl)(propyl)amino)-1-(pyridin-3-yl)ethanol (LK-935), the Novel Nonstatin-Type Cholesterol-Lowering Agent (2009) (27)
- Molecular cloning and functional expression of the cytochrome P450 11B-hydroxylase of the guinea pig. (1996) (26)
- Bacterial (CYP101) and mitochondrial P450 systems-how comparable are they? (2003) (26)
- Structure-Activity Profiles of Ab-Derived TNF Fusion Proteins1 (2006) (26)
- Construction and characterization of a catalytic fusion protein system: P-450(11beta)-adrenodoxin reductase-adrenodoxin. (2000) (26)
- Mutational effects on the spectroscopic properties and biological activities of oxidized bovine adrenodoxin, and their structural implications. (1995) (26)
- Binding modes of CYP106A2 redox partners determine differences in progesterone hydroxylation product patterns (2018) (26)
- Interaction of CYP11B1 (cytochrome P-45011 beta) with CYP11A1 (cytochrome P-450scc) in COS-1 cells. (1999) (25)
- Selective oxidation of carotenoid-derived aroma compounds by CYP260B1 and CYP267B1 from Sorangium cellulosum So ce56 (2016) (25)
- Substrate Hunting for the Myxobacterial CYP260A1 Revealed New 1α‐Hydroxylated Products from C‐19 Steroids (2016) (25)
- Some physicochemical properties of flour from germinated sorghum grain (2013) (25)
- CYP106A2-A versatile biocatalyst with high potential for biotechnological production of selectively hydroxylated steroid and terpenoid compounds. (2018) (24)
- Metabolism of Oral Turinabol by Human Steroid Hormone–Synthesizing Cytochrome P450 Enzymes (2016) (24)
- Protein phosphorylation and intermolecular electron transfer: a joint experimental and computational study of a hormone biosynthesis pathway. (2007) (23)
- Conversions of Tricyclic Antidepressants and Antipsychotics with Selected P450s from Sorangium cellulosum So ce56 (2015) (23)
- Conformational stability of bovine holo and apo adrenodoxin — A scanning calorimetric study (1995) (23)
- Functionalized PHB granules provide the basis for the efficient side-chain cleavage of cholesterol and analogs in recombinant Bacillus megaterium (2015) (22)
- Structure-Based Engineering of Steroidogenic CYP260A1 for Stereo- and Regioselective Hydroxylation of Progesterone. (2018) (22)
- Pro108 is important for folding and stabilization of adrenal ferredoxin, but does not influence the functional properties of the protein. (1997) (22)
- A single terpene synthase is responsible for a wide variety of sesquiterpenes in Sorangium cellulosum Soce56. (2016) (22)
- Phosphorylation of bovine adrenodoxin by protein kinase CK2 affects the interaction with its redox partner cytochrome P450scc (CYP11A1). (2005) (22)
- ThnY Is a Ferredoxin Reductase-like Iron-Sulfur Flavoprotein That Has Evolved to Function as a Regulator of Tetralin Biodegradation Gene Expression* (2010) (22)
- 2β- and 16β-hydroxylase activity of CYP11A1 and direct stimulatory effect of estrogens on pregnenolone formation (2015) (22)
- The potential of targeting CYP11B (2016) (21)
- A natural heme‐signature variant of CYP267A1 from Sorangium cellulosum So ce56 executes diverse ω‐hydroxylation (2015) (21)
- Highly Efficient CYP167A1 (EpoK) dependent Epothilone B Formation and Production of 7-Ketone Epothilone D as a New Epothilone Derivative (2015) (21)
- The steroid metabolite 16(β)-OH-androstenedione generated by CYP21A2 serves as a substrate for CYP19A1 (2017) (21)
- The role of adrenodoxin in adrenal steroidogenesis (2000) (21)
- Investigating the effect of available redox protein ratios for the conversion of a steroid by a myxobacterial CYP260A1 (2017) (20)
- Polyamines: naturally occurring small molecule modulators of electrostatic protein-protein interactions. (2010) (20)
- Reconstitution of cytochrome P4502B4 (LM2) activity with camphor and linalool monooxygenase electron donors. (1992) (20)
- Cyanobacterial electron carrier proteins as electron donors to CYP106A2 from Bacillus megaterium ATCC 13368. (2009) (20)
- Proteome analysis of Schizosaccharomyces pombe by two‐dimensional gel electrophoresis and mass spectrometry (2006) (20)
- Changed ratios of glucocorticoids/mineralocorticoids caused by point mutations in the putative I-helix regions of CYP11B1 and CYP11B2. (1996) (19)
- Function and engineering of the 15beta-hydroxylase CYP106A2. (2006) (19)
- Optimized chimeragenesis; creating diverse p450 functions. (2004) (19)
- Identification of new substrates for the CYP106A1‐mediated 11‐oxidation and investigation of the reaction mechanism (2015) (19)
- Five novel mutations in CYP11B2 gene detected in patients with aldosterone synthase deficiency type I: Functional characterization and structural analyses. (2010) (19)
- A CYP21A2 based whole-cell system in Escherichia coli for the biotechnological production of premedrol (2015) (19)
- Interactions of natural polyamines with mammalian proteins (2011) (19)
- Conformational stability of adrenodoxin mutant proteins (1996) (18)
- A novel CYP11B2 gene mutation in an Asian family with aldosterone synthase deficiency. (2006) (18)
- Chemical modification of cytochrome P-450 LM2. Characterization of tyrosine as axial heme iron ligand trans to thiolate. (1984) (18)
- Probing electronic and structural properties of the reduced [2Fe−2S] cluster by orientation-selective1H ENDOR spectroscopy: Adrenodoxin versus rieske iron-sulfur protein (2006) (18)
- Substitution of lysine with glutamic acid at position 193 in bovine CYP11A1 significantly affects protein oligomerization and solubility but not enzymatic activity. (2011) (18)
- Fluorescent energy transfer measurements on fluorescein isothiocyanate modified cytochrome P-450 LM2. (1983) (18)
- Modification of carboxyl groups on NADPH-cytochrome P-450 reductase involved in binding of cytochromes c and P-450 LM2. (1987) (18)
- CYP109E1 is a novel versatile statin and terpene oxidase from Bacillus megaterium (2017) (17)
- Functional characterization of Fdx1: evidence for an evolutionary relationship between P450-type and ISC-type ferredoxins. (2011) (17)
- Plasma membrane localization of CYP4Z1 and CYP19A1 and the detection of anti-CYP19A1 autoantibodies in humans. (2019) (17)
- Biotransformation of prednisone and dexamethasone by cytochrome P450 based systems - Identification of new potential drug candidates. (2017) (17)
- Engineering of CYP106A2 for steroid 9α- and 6β-hydroxylation (2017) (17)
- Crystal Structure of CYP106A2 in Substrate‐Free and Substrate‐Bound Form (2016) (16)
- A new application of the yeast two-hybrid system in protein engineering. (2007) (16)
- Insights into the design of a hybrid system between Anabaena ferredoxin-NADP+ reductase and bovine adrenodoxin. (2003) (16)
- The interaction domain of the redox protein adrenodoxin is mandatory for binding of the electron acceptor CYP11A1, but is not required for binding of the electron donor adrenodoxin reductase. (2005) (16)
- Aldosterone synthase deficiency caused by a homozygous L451F mutation in the CYP11B2 gene. (2008) (16)
- Direct and mediated electrochemical response of the cytochrome P450 106A2 from Bacillus megaterium ATCC 13368. (2012) (15)
- Phenotypic, metabolic, and molecular genetic characterization of six patients with congenital adrenal hyperplasia caused by novel mutations in the CYP11B1 gene (2016) (15)
- Inhibition Studies of Steroid Conversions Mediated by Human CYP11B1 and CYP11B2 Expressed in Cell Cultures (1998) (15)
- Characterization of cytochrome P450 CYP109E1 from Bacillus megaterium as a novel vitamin D3 hydroxylase. (2017) (15)
- Zone-specific localization of cytochrome P45011B1 in human adrenal tissue by PCR-derived riboprobes (1995) (15)
- Investigation of cytochromes P450 in myxobacteria: Excavation of cytochromes P450 from the genome of Sorangium cellulosum So ce56 (2011) (15)
- GroEL-assisted refolding of adrenodoxin during chemical cluster insertion. (2001) (15)
- Reversible, non-denaturing metal substitution in bovine adrenodoxin and spinach ferredoxin and the different reactivities of [2Fe-2S]-cluster-containing proteins. (1996) (14)
- Biochemical and structural characterization of CYP109A2, a vitamin D3 25‐hydroxylase from Bacillus megaterium (2017) (14)
- A Homozygous L299P Mutation in the CYP11B1 Gene Leads to Complete Virilization in 46,XX Individuals with 11-Beta-Hydroxylase Deficiency (2008) (14)
- Some properties of mitochondrial adrenodoxin associated with its nonconventional electron donor function toward rabbit liver microsomal cytochrome P450 2B4. (1999) (14)
- Use of high-performance liquid chromatography/electrospray ionization collision-induced dissociation mass spectrometry for structural identification of monohydroxylated progesterones. (2004) (14)
- The dipole moment of the electron carrier adrenodoxin is not critical for redox partner interaction and electron transfer. (2009) (14)
- The development of a whole-cell based medium throughput screening system for the discovery of human aldosterone synthase (CYP11B2) inhibitors: Old drugs disclose new applications for the therapy of congestive heart failure, myocardial fibrosis and hypertension (2011) (14)
- Expression of human CYP27A1 in B. megaterium for the efficient hydroxylation of cholesterol, vitamin D3 and 7-dehydrocholesterol. (2016) (14)
- Rabbit liver cytochrome P-450 2B5: high-level expression of the full-length protein in Escherichia coli, purification, and catalytic activity. (1995) (14)
- Identification of a new plasmid-encoded cytochrome P450 CYP107DY1 from Bacillus megaterium with a catalytic activity towards mevastatin. (2016) (14)
- CYP105A1 mediated 3-hydroxylation of glimepiride and glibenclamide using a recombinant Bacillus megaterium whole-cell catalyst. (2012) (14)
- The human mineralocorticoid receptor only partially differentiates between different ligands after expression in fission yeast. (2005) (13)
- Analysis of aldosterone-induced differential receptor-independent protein patterns using 2D-electrophoresis and mass spectrometry (2006) (13)
- Self-association of adrenodoxin studied by using analytical ultracentrifugation. (2007) (13)
- A Novel NADPH-dependent flavoprotein reductase from Bacillus megaterium acts as an efficient cytochrome P450 reductase. (2016) (13)
- Nongenomic Effect of Aldosterone on Ion Transport Pathways of Red Blood Cells (2008) (13)
- Characterization and engineering of a carotenoid biosynthesis operon from Bacillus megaterium. (2018) (13)
- Regioselective Acetylation of C21 Hydroxysteroids by the Bacterial Chloramphenicol Acetyltransferase I (2015) (13)
- New Sesquiterpene Oxidations with CYP260A1 and CYP264B1 from Sorangium cellulosum So ce56 (2015) (13)
- CYP267A1 and CYP267B1 from Sorangium cellulosum So ce56 are Highly Versatile Drug Metabolizers (2016) (13)
- Effect of replacing a conserved proline residue on the function and stability of bovine adrenodoxin. (1998) (13)
- Biotransformation of the mineralocorticoid receptor antagonists spironolactone and canrenone by human CYP11B1 and CYP11B2: Characterization of the products and their influence on mineralocorticoid receptor transactivation (2016) (12)
- Structure–function analysis for the hydroxylation of Δ4 C21‐steroids by the myxobacterial CYP260B1 (2016) (12)
- Structural and functional consequences of substitutions at the Pro108-Arg14 hydrogen bond in bovine adrenodoxin. (1998) (12)
- Analysis of the interaction of a hybrid system consisting of bovine adrenodoxin reductase and flavodoxin from the cyanobacterium Anabaena PCC 7119. (2004) (12)
- High-yield C11-oxidation of hydrocortisone by establishment of an efficient whole-cell system in Bacillus megaterium. (2019) (12)
- Development and application of a highly efficient CRISPR-Cas9 system for genome engineering in Bacillus megaterium. (2021) (11)
- A novel short chain dehydrogenase from Bacillus megaterium for the conversion of the sesquiterpene nootkatol to (+)-nootkatone. (2019) (11)
- Genetic engineering of Bacillus megaterium for high-yield production of the major teleost progestogens 17α,20β-di- and 17α,20β,21α-trihydroxy-4-pregnen-3-one. (2016) (11)
- Taurine modulates catalytic activity of cytochrome P450 3A4 (2015) (11)
- Structural and thermodynamic characterization of the adrenodoxin-like domain of the electron-transfer protein Etp1 from Schizosaccharomyces pombe. (2011) (11)
- Physicochemical properties of sorghum flour are selectively modified by combined germination-fermentation (2017) (11)
- Products of gut-microbial tryptophan metabolism inhibit the steroid hormone-synthesizing cytochrome P450 11A1 (2016) (10)
- Aldosterone: From biosynthesis to non-genomic action onto the proteome (2008) (10)
- Impact of the presequence of a mitochondrium-targeted precursor, preadrenodoxin, on folding, catalytic activity, and stability of the protein in vitro. (1998) (10)
- Scrutiny of electrochemically-driven electrocatalysis of C-19 steroid 1α-hydroxylase (CYP260A1) from Sorangium cellulosum So ce56. (2016) (10)
- Contribution of a salt bridge to the thermostability of adrenodoxin determined by site-directed mutagenesis. (2001) (10)
- Molecular Recognition between Azotobacter vinelandii Rhodanese and a Sulfur Acceptor Protein (2003) (10)
- CYP260B1 acts as 9α-hydroxylase for 11-deoxycorticosterone (2017) (10)
- Distance between lysine 384 and heme of cytochrome P-450 LM2 (P-450 IIB4) studied by fluorescence energy transfer measurements. (1989) (10)
- An indole‐deficient Escherichia coli strain improves screening of cytochromes P450 for biotechnological applications (2017) (10)
- A simple determination of the sideness of the NH2-terminus in the membrane bound cytochrome P-450 LM2. (1988) (9)
- A step toward understanding the folding mechanism of bovine adrenodoxin. (1999) (9)
- Mutations in aldosterone synthase gene of Milan hypertensive rats: phenotypic consequences. (2002) (9)
- Fission yeast Schizosaccharomyces pombe as a new system for the investigation of corticosterone methyloxidase deficiency-causing mutations (2011) (9)
- Cytochromes P450 as promising catalysts for biotechnological application: chances and limitations (2014) (8)
- Improvement of a P450-Based Recombinant Escherichia coli Whole-Cell System for the Production of Oxygenated Sesquiterpene Derivatives. (2017) (8)
- Six Uridine-Diphosphate Glycosyltransferases Catalyze the Glycosylation of Bioactive C13-Apocarotenols1 (2020) (8)
- CYP109E1 from Bacillus megaterium Acts as a 24‐ and 25‐Hydroxylase for Cholesterol (2019) (8)
- Structural characterization of CYP260A1 from Sorangium cellulosum to investigate the 1α‐hydroxylation of a mineralocorticoid (2016) (8)
- MODULATION OF STEROID HYDROXYLASE ACTIVITY IN STABLY TRANSFECTED V79MZH11B1 AND V79MZH11B2 CELLS BY PKC AND PKD INHIBITORS (2002) (8)
- Light-induced reduction of bovine adrenodoxin via the covalently bound ruthenium(II) bipyridyl complex: intramolecular electron transfer and crystal structure. (2006) (8)
- Novel approach to improve progesterone hydroxylation selectivity by CYP106A2 via rational design of adrenodoxin binding (2019) (8)
- Cluster-iron substitution is related to structural and functional features of adrenodoxin mutants and to their redox states. (1998) (8)
- Direct electron transfer of adrenodoxin—a [2Fe–2S] protein—and its mutants at modified gold electrode (1998) (8)
- Shotgun proteomic analysis of the microsomal fraction of eukaryotic cells using a two-dimensional reversed-phase x ion-pair reversed-phase HPLC setup. (2009) (8)
- Efficiency of the sulfate pathway in comparison to the Δ4- and Δ5-pathway of steroidogenesis in the porcine testis (2017) (7)
- Highly regio- and stereoselective hydroxylation of vitamin D2 by CYP109E1. (2020) (7)
- Sesquiterpenoids Produced by Combining Two Sesquiterpene Cyclases with Promiscuous Myxobacterial CYP260B1 (2019) (7)
- GroEL-assisted and -unassisted refolding of mature and precursor adrenodoxin: the role of the precursor sequence. (1999) (7)
- Immunocytochemical localization of heterologously expressed adrenodoxin and its electron acceptor cytochrome P45011B1 in Escherichia coli. (1994) (7)
- A new cytochrome P450 system from Bacillus megaterium DSM319 for the hydroxylation of 11-keto-β-boswellic acid (KBA) (2013) (6)
- Synthesis, Optimization, Antifungal Activity, Selectivity, and CYP51 Binding of New 2-Aryl-3-azolyl-1-indolyl-propan-2-ols (2020) (6)
- A conserved histidine in vertebrate-type ferredoxins is critical for redox-dependent dynamics. (2003) (6)
- Correction to: Bacterial steroid hydroxylases: enzyme classes, their functions and comparison of their catalytic mechanisms (2018) (6)
- A Novel Thermostable Cytochrome P450 from Sequence-Based Metagenomics of Binh Chau Hot Spring as a Promising Catalyst for Testosterone Conversion (2020) (5)
- Transforming growth factor 1 inhibits aldosterone and cortisol production in the human adrenocortical cell line NCI-H 295 R through inhibition of CYP 11 B 1 and CYP 11 B 2 expression (2003) (5)
- Expanding the promoter toolbox of Bacillus megaterium. (2019) (5)
- Investigating the roles of T224 and T232 in the oxidation of cinnamaldehyde catalyzed by myxobacterial CYP260B1 (2017) (5)
- Kinetic and optical biosensor study of adrenodoxin mutant AdxS112W displaying an enhanced interaction towards the cholesterol side chain cleavage enzyme (CYP11A1) (2011) (5)
- Effect of sulfonated steroids on steroidogenic cytochrome P450-dependent steroid hydroxylases (2017) (5)
- HIV Drug Efavirenz Inhibits CYP21A2 Activity with Possible Clinical Implications (2019) (5)
- Alu Sx repeat-induced homozygous deletion of the StAR gene causes lipoid congenital adrenal hyperplasia (2012) (5)
- Identification and circumvention of bottlenecks in CYP21A2‐mediated premedrol production using recombinant Escherichia coli (2019) (5)
- Resurrection and characterization of ancestral CYP11A1 enzymes (2021) (5)
- Characterization of the Stereoselective P450 Enzyme BotCYP Enables the In Vitro Biosynthesis of the Bottromycin Core Scaffold. (2020) (5)
- Bovine adrenodoxin--a mitochondrial iron-sulphur protein--binds to chaperonin GroEL. (1995) (5)
- New Molecular Genetic Defects Causing 11β-Hydroxylase Deficiency (CAH) (2000) (4)
- Structural characterization of CYP260A1 from Sorangium cellulosum to investigate the 1 alpha-hydroxylation of a mineralocorticoid. (2016) (4)
- Amino acid residues in I- and K-helices of rat CYP11B1 and CYP11B2 are important in expression of 18-hydroxylation activity. (1998) (4)
- Combination Effect of Germination and Fermentation on Functional Properties of Sorghum Flour (2018) (4)
- Purification and functional characterization of human 11b hydroxylase expressed in Escherichia coli (2008) (4)
- Inhibition of aldosterone biosynthesis by staurosporine (2005) (4)
- Human CYP27A1 catalyzes hydroxylation of β-sitosterol and ergosterol (2016) (4)
- Functionalized poly(3-hydroxybutyric acid) bodies as new in vitro biocatalysts. (2018) (4)
- A novel NADPH-dependent flavoprotein reductase from Bacillus megaterium acts as an efficient cytochrome P450 reductase (2016) (4)
- Chemical modification of cytochrome P-450 LM2 with N-acetylimidazole. Evidence for the functional involvement of tyrosyl residues. (1985) (4)
- Underestimated reactions and regulation patterns of adrenal cytochromes P450 (2021) (4)
- The “bringer” strategy (2004) (3)
- The Effects of Rosuvastatin and the CYP51A1 Inhibitor LEK-935 on the Proteome of Primary Human Hepatocytes (2012) (3)
- The impact of the clinical CYP11B2 mutation V386A strongly depends on the enzyme's genetic background. (2017) (3)
- Chemical Probes of Cytochrome P450 Structure (1993) (3)
- An Isotopic Labelling Strategy to Study Cytochrome P450 Oxidations of Terpenes (2018) (3)
- Improvement of the 25-hydroxyvitamin D3 production in a CYP109A2-expressing Bacillus megaterium system. (2020) (3)
- Structure of adrenodoxin and function in mitochondrial steroid hydroxylation. (1998) (3)
- The human adrenal gland as a drug metabolizer: First in-vivo evidence for the conversion of steroidal drugs (2019) (3)
- Structure-function studies on mutants of adrenal ferredoxin. (1995) (3)
- Biocatalytic synthesis of 4-pregnen-20,21-diol-3-one, a selective inhibitor of human 5α-reductase type II (2007) (3)
- [The effect of cholesterol on the structure and function of the endoplasmic reticulum]. (1981) (3)
- Investigation of Protein-Protein Interactions in Mitochondrial Steroid Hydroxylase Systems Using Site-Directed Mutagenesis (1995) (3)
- Identification of lysine (384) in cytochrome P-450 LM2 as functionally linked residue. (1984) (3)
- Characterization of a thermophilic cytochrome P450 of the CYP203A subfamily from Binh Chau hot spring in Vietnam (2020) (2)
- Electron Transfer in Mitochondrial Steroid Hydroxylating Cytochrome P450 Systems: Role of Adrenodoxin (1998) (2)
- Functional expression of the guinea pig 11b-hydroxylase in COS-1 cells. (1996) (2)
- Mixed-culture fermentation for enhanced C21-hydroxylation of glucocorticoids. (2020) (2)
- Structural insights into oxidation of medium-chain fatty acids and flavanone by myxobacterial cytochrome P450 CYP267B1. (2018) (2)
- Mammalian and Bacterial Cytochromes P450 Involved in Steroid Hydroxylation: Regulation of Catalysis and Selectivity, and Potential Applications (2014) (2)
- CYP109E1 is a novel versatile statin and terpene oxidase from Bacillus megaterium (2017) (2)
- Inside Cover: New Sesquiterpene Oxidations with CYP260A1 and CYP264B1 from Sorangium cellulosum So ce56 (ChemBioChem 18/2015) (2015) (1)
- Bioenergetics Theory and Components | Cytochrome P450 (2021) (1)
- Investigation of cytochromes P 450 in myxobacteria : Excavation of cytochromes P 450 from the genome of Sorangium cellulosum So ce 56 (2011) (1)
- Raman and infrared spectroscopic evidence for the structural changes of the 2Fe2S cluster and its environment during the interaction of adrenodoxin and adrenodoxin reductase. (2017) (1)
- Direct electrochemistry of CYP109C1, CYP109C2 and CYP109D1 from Sorangium cellulosum So ce56 (2016) (1)
- CHANGED RATIOS OF GLUCOCORTICOIDSO CORTICOIDS CAUSED BY POINT MUTATONS IN THE PUTATIVE I-HELM REGIONS OF CYPllBl AND CYPllB2 (1996) (1)
- Activity of 5'-deletion mutants of the human CYP11B1 promoter in H295R cells. (1996) (1)
- Bacterial steroid hydroxylases: enzyme classes, their functions and comparison of their catalytic mechanisms (2018) (1)
- STRUCTURAL AND THERMODYNAMIC CHARACTERIZATION OF THE ADRENODOXIN-LIKE DOMAIN OF THE ELECTRON-TRANSFER PROTEIN ETP 1 FROM SCHIZOSACCHAROMYCES POMBE * (2011) (1)
- Changing Substrate Specificity and Product Pattern in Adrenal Cytochrome P-450-Dependent Steroid Hydroxylases (1998) (0)
- Mutations of adrenal ferredoxin that affect the formation of the iron-sulfur cluster and its biochemical and biophysical properties (1995) (0)
- Engineering of versatile redox partner fusions that support monooxygenase activity of functionally diverse cytochrome P450s (2017) (0)
- Metabolism of oral turinabol by the human brain cholesterol 24-hydroxylase CYP46A1 (2021) (0)
- Application of a new versatile electron transfer system for cytochrome P450-based Escherichia coli whole-cell bioconversions (2012) (0)
- Structural insights into oxidation of medium-chain fatty acids and flavanone by myxobacterial cytochrome P 450 CYP 267 B 1 (2018) (0)
- Molecolar recognition between Azotobacter vinelandii rhodanese and putative sulfur acceptor proteins (2003) (0)
- STRUCTURE OF REDUCED BOVINE ADRENODOXIN (2002) (0)
- Taurine modulates catalytic activity of cytochrome P450 3A4 (2015) (0)
- Structure of human ferredoxin 2 (Fdx2)in complex with 2Fe2S cluster (2012) (0)
- Development and evaluation of a whole-cell system for the directed evolution of human cytochromes P450 in recombinant fission yeast Schizosaccharomyces pombe (2014) (0)
- Production of steroid hormones by fission yeast cells expressing human mitochondrial cytochromes P450 (2002) (0)
- Protein cross-talk and redox events relevant to the biogenesis of FeS structures in mitochondria from Schizosaccaromyces pombe (2010) (0)
- CYP106A2 WITH SUBSTRATE ABIETIC ACID (2016) (0)
- Obituary: IN MEMORIAM PROF. DR. KLAUS RUCKPAUL (2018) (0)
- Author response for "Resurrection and characterization of ancestral CYP11A1 enzymes" (2021) (0)
- Ru(bpy)2(mbpy)-Modified Bovine Adrenodoxin (2006) (0)
- Heterologous production of a sesquiterpene in Escherichia coli (2015) (0)
- Preface — In honor of Klaus Ruckpaul (2011) (0)
- Correction to: Bacterial steroid hydroxylases: enzyme classes, their functions and comparison of their catalytic mechanisms (2018) (0)
- Structural comparison of the cytochrome P450 enzymes CYP106A1 and CYP106A2 provides insight into their differences in steroid conversion (2022) (0)
- Purification and functional characterization of human 11 hydroxylase expressed in Escherichiacoli (2008) (0)
- Cloning and heterologous expression in Escherichia coli of the fission yeast vip1 gene, showing differential expression after aldosterone treatment (2009) (0)
- REVIEWERS ACKNOWLEDGEMENT (2009) (0)
- Cytochrome P450 dependent steroid hydroxylases and their application in biotechnology and medicine (2002) (0)
- Optimization of redox partner interactions with cytochromes P450 (CYP) (2016) (0)
- Session Summary (2000) (0)
- Adrenodoxin-like ferredoxin Etp1fd(516-618) of Schizosaccharomyces pombe mitochondria (2010) (0)
- ThnY is a ferredoxin reductase-like iron-sulfur flavoprotein that has evolved to function as a regulator of tetralin biodegradation gene expression. (2012) (0)
- NMR STRUCTURE OF OXIDIZED ADRENODOXIN (2002) (0)
- Selective oxidation of carotenoid-derived aroma compounds by CYP260B1 and CYP267B1 from Sorangium cellulosum So ce56 (2016) (0)
- CCDC 1009047: Experimental Crystal Structure Determination (2017) (0)
- Adrenodoxin and cytochromes P450 (2006) (0)
- Design and characterization of an efficient CYP105A1-based whole-cell biocatalyst for the conversion of resin acid diterpenoids in permeabilized Escherichia coli (2013) (0)
- Evaluation of CYP11Bs expression in HCT116 cells (2012) (0)
- Structural and Functional Analysis of Novel Human Cytochrome c Targets in Apoptosis*□S (2014) (0)
- Autodisplay funktioneller P450-Enzyme in Escherichia coli (2010) (0)
- Chapter 4 Crystal structure of the vitamin D 3 hydroxylating enzyme CYP 109 A 2 (2018) (0)
- Cytochrome P-450 (2013) (0)
- Using the yeast two-hybrid system as in vivo screening-system for interactions between adrenodoxin and its redoxpartners (2002) (0)
- Sorangium cellulosum So Ce56 cytochrome P450 260B1 (2016) (0)
- Glycosylation of bioactive C13-apocarotenols in Nicotiana benthamiana and Mentha × piperita (2020) (0)
- Binding modes of CYP106A2 redox partners determine differences in progesterone hydroxylation product patterns (2018) (0)
- In honor of Klaus Ruckpaul. Preface. (2011) (0)
- Production and purification of tailor made, stable PHB bodies with complex human heme protein (2016) (0)
- Protein recognition in cofactor synthesis: the case of RhdA and Fe-S proteins (2002) (0)
- Old drugs for new targets - CYP11B2 inhibitors for hypertension (2012) (0)
- CYP264B1 from Sorangium cellulosum So ce56: a fascinating norisoprenoid and sesquiterpene hydroxylase (2012) (0)
- IN VITRO AND IN VIVO CHARACTERIZATION OF CYP 11 A 1 , CYP 17 A 1 AND CHLORAMPHENICOL ACETYLTRANSFERASE-DEPENDENT STEROID CONVERSION (2015) (0)
- Identification of a novel CYP11B1 isoform in human adrenocortical cells (2013) (0)
- A new Bacillus megaterium whole-cell catalyst for the hydroxylation of the pentacyclic triterpene 11-keto-β-boswellic acid (KBA) based on a recombinant cytochrome P450 system (2011) (0)
- Molecular Mechanisms of Component Interactions of the Liver Microsomal Cytochrome P-450 System (1981) (0)
- Comparison of CYP106A1 and CYP106A2 from Bacillus megaterium – identification of a novel 11-oxidase activity (2015) (0)
- Preface (2007) (0)
- A CYPome-wide study reveals new potential players in the pathogenesis of Parkinson’s disease (2023) (0)
- [Molecular biology methods for the study of the cytochrome P-450 system and its potential applications]. (1985) (0)
- Structural and Functional Analysis of Novel Human Cytochrome c Targets in Apoptosis Running Title : Novel Human Cytochrome c Targets (2014) (0)
- Solution model of crosslinked complex of cytochrome c and adrenodoxin (2008) (0)
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What Schools Are Affiliated With Rita Bernhardt?
Rita Bernhardt is affiliated with the following schools:
