Robert a. Kastelein
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Robert a. Kasteleinbiology Degrees
Biology
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#15340
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Immunology
#781
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#804
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Neuroscience
#1966
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#2022
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Biology
Robert a. Kastelein's Degrees
- PhD Immunology Stanford University
- Doctorate Medicine Stanford University
Why Is Robert a. Kastelein Influential?
(Suggest an Edit or Addition)Robert a. Kastelein's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- IL-23 drives a pathogenic T cell population that induces autoimmune inflammation (2005) (4179)
- IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. (2005) (3338)
- Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain (2003) (3016)
- Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. (2000) (2852)
- Subsets of Human Dendritic Cell Precursors Express Different Toll-like Receptors and Respond to Different Microbial Antigens (2001) (2212)
- Development, cytokine profile and function of human interleukin 17–producing helper T cells (2007) (2100)
- Human epithelial cells trigger dendritic cell–mediated allergic inflammation by producing TSLP (2002) (2014)
- A family of human receptors structurally related to Drosophila Toll. (1998) (1949)
- Divergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune Inflammation (2003) (1810)
- IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. (2006) (1574)
- IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells. (2002) (1445)
- Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes. (1992) (1315)
- A Receptor for the Heterodimeric Cytokine IL-23 Is Composed of IL-12Rβ1 and a Novel Cytokine Receptor Subunit, IL-23R1 (2002) (1291)
- The IL-12 family of heterodimeric cytokines: new players in the regulation of T cell responses. (2003) (963)
- Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria. (2004) (947)
- IL-23 promotes tumour incidence and growth (2006) (947)
- IL-23 induces spondyloarthropathy by acting on ROR-γt+ CD3+CD4−CD8− entheseal resident T cells (2012) (910)
- Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation. (2007) (786)
- Understanding the IL-23-IL-17 immune pathway. (2006) (783)
- IL‐12 and IL‐23: master regulators of innate and adaptive immunity (2004) (779)
- IGIF Does Not Drive Th1 Development but Synergizes with IL-12 for Interferon-γ Production and Activates IRAK and NFκB (1997) (756)
- Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI. (1991) (735)
- WSX-1 and Glycoprotein 130 Constitute a Signal-Transducing Receptor for IL-27 (2004) (706)
- IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2–dependent mechanisms with implications for psoriasis pathogenesis (2006) (638)
- Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis. (2006) (613)
- IL‐23 and the Th17 pathway promote inflammation and impair antifungal immune resistance (2007) (579)
- Interleukin 10, a novel B cell stimulatory factor: unresponsiveness of X chromosome-linked immunodeficiency B cells (1990) (529)
- The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection. (2003) (521)
- IL-1 Receptor Accessory Protein and ST2 Comprise the IL-33 Receptor Complex (2007) (493)
- Monoclonal anti-interleukin 23 reverses active colitis in a T cell-mediated model in mice. (2007) (483)
- Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs (1994) (476)
- Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling (2009) (458)
- Human Thymic Stromal Lymphopoietin Preferentially Stimulates Myeloid Cells1 (2001) (410)
- IL-25 regulates Th17 function in autoimmune inflammation (2007) (405)
- Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation (2009) (381)
- Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract (2006) (380)
- IL-27 Blocks RORc Expression to Inhibit Lineage Commitment of Th17 Cells (2009) (332)
- IL-27 and IFN-α Signal via Stat1 and Stat3 and Induce T-Bet and IL-12Rβ2 in Naive T Cells (2003) (317)
- Ubiquitous Transgenic Expression of the IL-23 Subunit p19 Induces Multiorgan Inflammation, Runting, Infertility, and Premature Death (2001) (308)
- A newly defined interleukin-1? (1996) (299)
- Commensal-dependent expression of IL-25 regulates the IL-23–IL-17 axis in the intestine (2008) (295)
- Novel IL-12 family members shed light on the orchestration of Th1 responses (2003) (291)
- IL-25 elicits a multi-potent progenitor cell population that promotes Th2 cytokine responses (2010) (288)
- Differential regulation of interleukin 12 and interleukin 23 production in human dendritic cells (2008) (282)
- Modulation of murine macrophage function by IL-13. (1993) (266)
- IGIF does not drive Th1 development but synergizes with IL-12 for interferon-gamma production and activates IRAK and NFkappaB. (1997) (265)
- Identification of a novel selD homolog from eukaryotes, bacteria, and archaea: is there an autoregulatory mechanism in selenocysteine metabolism? (1996) (235)
- IL-27 Limits IL-2 Production during Th1 Differentiation1 (2006) (232)
- Two Novel IL-1 Family Members, IL-1δ and IL-1ε, Function as an Antagonist and Agonist of NF-κB Activation Through the Orphan IL-1 Receptor-Related Protein 21 (2001) (229)
- Cutting Edge: A Critical Functional Role for IL-23 in Psoriasis (2010) (220)
- IL-23 Enhances the Inflammatory Cell Response in Cryptococcus neoformans Infection and Induces a Cytokine Pattern Distinct from IL-121 (2006) (219)
- Interleukin-27: balancing protective and pathological immunity. (2012) (217)
- IL-33 Induces IL-13–Dependent Cutaneous Fibrosis (2009) (207)
- IL‐10 enhances NK cell proliferation, cytotoxicity and production of IFN‐γ when combined with IL‐18 (1999) (204)
- Codon replacement in the PGK1 gene of Saccharomyces cerevisiae: experimental approach to study the role of biased codon usage in gene expression (1987) (201)
- A new nomenclature for IL-1-family genes. (2001) (177)
- IL-27 Mediates Complete Regression of Orthotopic Primary and Metastatic Murine Neuroblastoma Tumors: Role for CD8+ T Cells1 (2004) (173)
- IL-23 Provides a Limited Mechanism of Resistance to Acute Toxoplasmosis in the Absence of IL-121 (2004) (172)
- Neutralization of IL‐17 by active vaccination inhibits IL‐23‐dependent autoimmune myocarditis (2006) (170)
- The Essential Role of Single Ig IL-1 Receptor-Related Molecule/Toll IL-1R8 in Regulation of Th2 Immune Response1 (2009) (163)
- IL-27 and IFN-alpha signal via Stat1 and Stat3 and induce T-Bet and IL-12Rbeta2 in naive T cells. (2003) (158)
- Expression of IL‐27 in human Th1‐associated granulomatous diseases (2004) (144)
- IL-23 Production by Cosecretion of Endogenous p19 and Transgenic p40 in Keratin 14/p40 Transgenic Mice: Evidence for Enhanced Cutaneous Immunity (2003) (143)
- A Critical Role for Interleukin 18 in Primary and Memory Effector Responses to Listeria monocytogenes That Extends Beyond Its Effects on Interferon γ Production (2001) (142)
- Comparison of the effects of interleukin‐1α, interleukin‐lβ and interferon‐γ‐inducing factor on the production of interferon‐γ by natural killer (1997) (141)
- Mouse T Cell Membrane Proteins Rt61 and Rt62 Are Arginine/Protein Mono(ADPribosyl)transferases and Share Secondary Structure Motifs with ADP-ribosylating Bacterial Toxins (*) (1996) (141)
- OB-BP1/Siglec-6 (1999) (140)
- Swords into plowshares: IL-23 repurposes tumor immune surveillance. (2007) (135)
- Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2. (2001) (135)
- Mouse IL-17: A Cytokine Preferentially Expressed by αβTCR+CD4—CD8— T Cells (1996) (135)
- Protective Immunity to Systemic Infection with Attenuated Salmonella enterica serovar Enteritidis in the Absence of IL-12 Is Associated with IL-23-Dependent IL-22, but Not IL-171 (2008) (132)
- Interleukin-23 is sufficient to induce rapid de novo gut tumorigenesis, independent of carcinogens, through activation of innate lymphoid cells (2013) (126)
- Molecular cloning of a cDNA encoding the human interleukin 4 receptor. (1990) (118)
- FLK-2/FLT-3 ligand regulates the growth of early myeloid progenitors isolated from human fetal liver. (1995) (111)
- Molecular characterization and modular analysis of human MyD88. (1996) (110)
- IL-18 and CD28 use distinct molecular mechanisms to enhance NK cell production of IL-12-induced IFN-gamma. (1999) (99)
- CHAPTER 8 – Biased Codon Usage: An Exploration of Its Role in Optimization of Translation (1986) (96)
- Lysis gene expression of RNA phage MS2 depends on a frameshift during translation of the overlapping coat protein gene (1982) (94)
- Immunologic and Therapeutic Synergy of IL-27 and IL-2: Enhancement of T Cell Sensitization, Tumor-Specific CTL Reactivity and Complete Regression of Disseminated Neuroblastoma Metastases in the Liver and Bone Marrow1 (2009) (89)
- Immunological and Antitumor Effects of IL-23 as a Cancer Vaccine Adjuvant1 (2006) (87)
- #2202: Mucosal Autoimmunity Saturday, June 13 10:45 am–11:00 amCirculating and Gut-resident Human Th17 Cells Express CD161 and Promote Intestinal Inflammation (2009) (83)
- IL-18 Receptors, Their Role in Ligand Binding and Function: Anti-IL-1RAcPL Antibody, a Potent Antagonist of IL-181 (2000) (80)
- The amino‐terminal helix of GM‐CSF and IL‐5 governs high affinity binding to their receptors. (1991) (75)
- Neutralization or Absence of the Interleukin-23 Pathway Does Not Compromise Immunity to Mycobacterial Infection (2006) (71)
- Analysis of interleukin-27 (EBI3/p28) expression in Epstein-Barr virus- and human T-cell leukemia virus type 1-associated lymphomas: heterogeneous expression of EBI3 subunit by tumoral cells. (2005) (66)
- Differential Effects of IL-27 on Human B Cell Subsets1 (2006) (63)
- TGF-β, a 'double agent' in the immune pathology war (2006) (62)
- Expression, renaturation and purification of recombinant human interleukin 4 from Escherichia coli. (1988) (60)
- The leptin haemopoietic cytokine fold is stabilized by an intrachain disulfide bond. (1996) (57)
- Identification of critical amino acid residues in human and mouse granulocyte-macrophage colony-stimulating factor and their involvement in species specificity. (1991) (56)
- Langowski JL, Zhang XQ, Wu LL et al.IL-23 promotes tumour incidence and growth. Nature 442:461-465 (2006) (55)
- Investigating the role of the interleukin-23/-17A axis in rheumatoid arthritis (2009) (55)
- Effect of the sequences upstream from the ribosome-binding site on the yield of protein from the cloned gene for phage MS2 coat protein. (1983) (52)
- Mouse IL-17: a cytokine preferentially expressed by alpha beta TCR + CD4-CD8-T cells. (1996) (51)
- Biomarkers of Therapeutic Response in the IL-23 Pathway in Inflammatory Bowel Disease (2012) (51)
- Differential effects of IL-27 on human B cell subsets (2006) (46)
- Prostaglandin E 2 regulates Th 17 cell diff erentiation and function through cyclic AMP and EP 2 / EP 4 receptor signaling (2009) (46)
- Identification of critical regions in mouse granulocyte-macrophage colony-stimulating factor by scanning-deletion analysis. (1989) (44)
- Expression of interleukin-27 by human trophoblast cells. (2007) (44)
- Comparison of the effects of interleukin-1 alpha, interleukin-1 beta and interferon-gamma-inducing factor on the production of interferon-gamma by natural killer. (1997) (43)
- Genetic structure and chromosomal mapping of MyD88. (1997) (42)
- TGF-beta, a 'double agent' in the immune pathology war. (2006) (39)
- High affinity ligand binding is not essential for granulocyte-macrophage colony-stimulating factor receptor activation. (1992) (38)
- Signaling Events Involved in Interleukin 27 (IL-27)-induced Proliferation of Human Naive CD4+ T Cells and B Cells* (2011) (36)
- Uncovered: the family relationship of a T-cell-membrane protein and bacterial toxins. (1996) (36)
- Computational identification, cloning, and characterization of IL-1R9, a novel interleukin-1 receptor-like gene encoded over an unusually large interval of human chromosome Xq22.2-q22.3. (2000) (35)
- Borrelia burgdorferi potently activates bone marrow-derived conventional dendritic cells for production of IL-23 required for IL-17 release by T cells. (2007) (35)
- Opening the closed ribosome-binding site of the lysis cistron of bacteriophage MS2 (1983) (35)
- Administration of IL-23 engages innate and adaptive immune mechanisms during fungal infection. (2010) (33)
- Isolation, characterization and chromosomal localization of human WNT10B. (1997) (28)
- Functional Replacement of Cytokine Receptor Extracellular Domains by Leucine Zippers* (1996) (26)
- Translational interference at overlapping reading frames in prokaryotic messenger RNA. (1985) (25)
- Requirement of hydrophilic amino-terminal residues for granulocyte-macrophage colony-stimulating factor bioactivity and receptor binding. (1992) (25)
- tuf gene dosage effects on the intracellular concentration of EF-TuB. (1983) (24)
- Cytokine Receptor Subunit , IL-23 R 1 and a Novel β IL-23 Is Composed of IL-12 R A Receptor for the Heterodimeric Cytokine (2002) (23)
- Binding of leptin to the soluble ectodomain of recombinant leptin receptor: a kinetic analysis by surface plasmon resonance. (1996) (22)
- The IL-12 Family of Cytokines (2003) (19)
- Rational Design of a Mouse Granulocyte Macrophage- Colony-stimulating Factor Receptor Antagonist (*) (1995) (17)
- GM-CSF receptor: interactions and activation. (1993) (16)
- Expression and purification of a synthetic human obese gene product. (1995) (15)
- An orthogonal IL-2 and IL-2Rβ system drives persistence and activation of CAR T cells and clearance of bulky lymphoma (2021) (13)
- Expression of biologically active, mature human granulocyte-macrophage colony stimulating factor with anE. coli secretory expression system (1988) (8)
- Secretion of murine and human interleukin-2 by Escherichia coli (1989) (8)
- Non-ribosomal nucleotide sequences in 7-S RNA, the immediate precursor of 5.8-S ribosomal RNA in yeast. (1978) (7)
- Evaluation of murine interleukin 4 (IL-4) receptor expression using anti-receptor monoclonal antibodies and S1 nuclease protection analyses. (1991) (5)
- Cytoplasmic and periplasmic expression of a highly basic protein, human interleukin 4, inEscherichia coli (1990) (5)
- Biophysical and Immunological Characterization and In Vivo Pharmacokinetics and Toxicology in Nonhuman Primates of the Anti-PD-1 Antibody Pembrolizumab (2020) (5)
- Exploiting the cell membrane for the production of heterologous proteins in Escherichia coli (1990) (3)
- Cloning and overexpression of the colicin E1 immunity gene. (1987) (2)
- Subject Index, Vol. 77, 1997 (1997) (2)
- Interleukin 23 is critical in the pathogenesis of spondyloarthropathy and acts on a novel population of interleukin 23R+ entheseal resident cells (2013) (2)
- RIBOSOMAL FRAMESHIFT ERRORS CONTROL THE EXPRESSION OF AN OVERLAPPING GENE IN RNA PHAGE (1982) (2)
- Abstract 1744: STK-012, an alpha/beta selective IL-2 mutein for the activation of the antigen-activated T cells in solid tumor (2021) (2)
- Preferentially Stimulates Myeloid Cells Human Thymic Stromal Lymphopoietin (2012) (1)
- An IL-6 receptor antagonist for IL-6 activity on human myeloma cells (1994) (1)
- IL-23 drives the expansion of pathogenic ThIL-17 cells required for autoimmune inflammation (2005) (1)
- New paradigms in inflammation: where to next? (2008) (1)
- The IL-23/IL-17 pathway impairs antifungal immune resistance (2007) (1)
- Development of the anti-IL-10 mAb MK-1966 in combination with in situ vaccination of a TLR9 agonist SD-101 for cancer immunotherapy (2016) (1)
- Toxoplasma gondii Independent Mechanisms of Resistance to Identification of STAT 4-Dependent and Kastelein and (2000) (1)
- Not IL-17 Associated with IL-23-Dependent IL-22, but Enteritidis in the Absence of IL-12 Is serovar Salmonella enterica with Attenuated Protective Immunity to Systemic Infection (2008) (1)
- Functional dissection of interleukin-17 in the pathogenesis of psoriasis (2007) (1)
- Bone Marrow Neuroblastoma Metastases in the Liver and and Complete Regression of Disseminated Sensitization , Tumor-Specific CTL Reactivity IL-27 and IL-2 : Enhancement of T Cell Immunologic and Therapeutic Synergy of and (2009) (1)
- Immunologic and Therapeutic Synergy of IL-27 and IL-2: Complete Regression of Neuroblastoma Metastases in the Liver and Bone Marrow (2005) (1)
- Involvement of the fourth alpha-helix of mouse granulocyte-macrophage colony-stimulating factor in binding to the alpha-subunit of the receptor complex. (1995) (1)
- for Enhanced Cutaneous Immunity Keratin 14/p40 Transgenic Mice: Evidence Endogenous p19 and Transgenic p40 in IL-23 Production by Cosecretion of (2003) (0)
- Combinaison d'un anticorps anti-il-10 et d'un oligonucléotide de type cpg-c pour le traitement du cancer (2016) (0)
- receiving mammalian protein; reagents and related methods. (2000) (0)
- New paradigms in inflammation (2008) (0)
- Determination of the functional biology of IL‐25 (2008) (0)
- Abstract 1512: OrthoCARs: Engineered human IL-2/IL-2Rb orthogonal pairs selectively enhance CAR T cell antitumor efficacy by driving T cell expansion and fitness (2021) (0)
- Cytokines related to mammalian interleukin 17. polynucleotides that encode them. applications. (2000) (0)
- Commensal‐dependent regulation of the IL‐17 cytokine family governs susceptibility to intestinal inflammation (2008) (0)
- isolated from human fetal liver FLK-2/FLT-3 ligand regulates the growth of early myeloid progenitors (2011) (0)
- Genetic and functional evidence for a role of the interleukin 23 pathway in the pathogenesis of psoriasis (2007) (0)
- Comprise the IL-33 Receptor Complex IL-1 Receptor Accessory Protein and ST 2 (2007) (0)
- human receptor proteins similar to toll, reagents and related methods. (1998) (0)
- David Aspergillus fumigatus Inhaled Immunocompetent Mice in Response to Cytokine Networking in Lungs of (2000) (0)
- A novel cytokine belonging to the IL-10 gene family affects human monocytes and T cells (1997) (0)
- Mammalian cytokines: reagents and associated procedures. (2000) (0)
- DifferentiationLimits IL-2 Production during Th1 (2013) (0)
- IL-23 as a Cancer Vaccine Adjuvant Immunological and Antitumor Effects of (2013) (0)
- Distinct from IL-12 Infection and Induces a Cytokine Pattern Cryptococcus neoformans Response in IL-23 Enhances the Inflammatory Cell (2005) (0)
- Evidence for a Role of the Interleukin-23 Pathway in the Pathogenesis of Psoriasis (2007) (0)
- Cytokine mammal; related reagents. (2000) (0)
- human receptor proteins toll-like, reagents and related methods. (1998) (0)
- Abstract 2824: Engineered human IL-2/IL-2Rb orthogonal pairs selectively enhance anti-GPC3 CAR T cells to drive complete responses in solid epithelial tumor models (2022) (0)
- Abstract 1801: STK-012, an a/b-selective IL-2 activates tumor antigen specific CD25+ CD8 T cells to reject tumors without acute vascular toxicity (2023) (0)
- Cytokinreceptorunderenhedproteiner mammalian merchandise belonging to reagents and methods (2001) (0)
- Codon Replacement in the PGKI Gene of Saccharomyces (2003) (0)
- Functional evidence for a role of interleukin-23 in the pathogenesis of psoriasis. (2007) (0)
- Interleukin-12 p40 and interleukin-b30. combinations thereof. antibody. uses in pharmaceutical compositions (2000) (0)
- Use of antagonists of IL-23 and IL-17 to treat autoimmune ocular inflammatory disease. (2006) (0)
- mammals from Zytokinrezeptoruntereinheit-proteins, related reagents and methods (2001) (0)
- Abstract 1833: Novel IL-12 Partial Agonist For Cancer Immunotherapy Avoids NK-cell Mediated Toxicity (2023) (0)
- 32 IL-27P28 Protects Mice From EAE (2007) (0)
- for polynucleotides encoding. uses (2000) (0)
- Abstract 3252:OrthoCARs: Engineered human IL-2/IL-2Rb orthogonal pairs selectively enhance CAR T cell anti-tumor efficacy and durability of response (2020) (0)
- Psoriasis and skin diseases (WS-055) Chairpersons: Masayuki Amagai, Akira Takashima (2010) (0)
- Premature Death Inflammation , Runting , Infertility , and IL-23 Subunit p 19 Induces Multiorgan Ubiquitous Transgenic Expression of the Satwant Narula (2001) (0)
- IL-25 the IL-23-IL-17 axis in the (2008) (0)
- Cytokines mammals from and associated reagents (2000) (0)
- Association d'un antagoniste du pd-1 et d'un oligonucléotide cpg du type c pour le traitement du cancer (2016) (0)
- Lineage Commitment of Th 17 Cells IL-27 Blocks RORc Expression to Inhibit (2009) (0)
- a cytokine antagonist antibodies or mammalian receptor for allergy treatment (2001) (0)
- This information is current as Signal-Transducing Receptor for IL-27 WSX-1 and Glycoprotein 130 Constitute a (2004) (0)
- subunits Proteins cotocinas receptors of mammals, reagents and related methods. (2001) (0)
- Interleukin-27 Enhances Tumor Cell MHC Class I Expression and Specific T Cell Reactivity and Mediates CD8+ T-Cell Dependent Regression of Primary and/or Metastatic Murine Neuroblastoma Tumors (2004) (0)
- Use of IL-23 and IL-17 antagonists for the treatment of autoimmune inflammatory eye disease (2006) (0)
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