Robert Benezra
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Cell Biology
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Biology
Robert Benezra's Degrees
- Masters Biochemistry Stanford University
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(Suggest an Edit or Addition)Robert Benezra's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The protein Id: A negative regulator of helix-loop-helix DNA binding proteins (1990) (2190)
- Impaired recruitment of bone-marrow–derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth (2001) (1988)
- The myoD gene family: nodal point during specification of the muscle cell lineage. (1991) (1498)
- Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts (1999) (963)
- MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells (2001) (789)
- Vascular and haematopoietic stem cells: novel targets for anti-angiogenesis therapy? (2002) (717)
- Identification of a Human Mitotic Checkpoint Gene: hsMAD2 (1996) (672)
- Mad2 overexpression promotes aneuploidy and tumorigenesis in mice. (2007) (627)
- Tumor entrained neutrophils inhibit seeding in the premetastatic lung. (2011) (616)
- Id proteins in development, cell cycle and cancer. (2003) (604)
- Therapy-Induced Acute Recruitment of Circulating Endothelial Progenitor Cells to Tumors (2006) (595)
- Chromosome Missegregation and Apoptosis in Mice Lacking the Mitotic Checkpoint Protein Mad2 (2000) (566)
- Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control (2004) (564)
- Overexpression of Id protein inhibits the muscle differentiation program: in vivo association of Id with E2A proteins. (1992) (464)
- Rapid chemotherapy-induced acute endothelial progenitor cell mobilization: implications for antiangiogenic drugs as chemosensitizing agents. (2008) (445)
- Mitotic chromosomal instability and cancer: mouse modelling of the human disease (2010) (421)
- Bone marrow-derived endothelial progenitor cells are a major determinant of nascent tumor neovascularization. (2007) (416)
- The ID proteins: master regulators of cancer stem cells and tumour aggressiveness (2014) (301)
- Id family of helix-loop-helix proteins in cancer (2005) (291)
- Expansion and maintenance of human embryonic stem cell–derived endothelial cells by TGFβ inhibition is Id1 dependent (2010) (287)
- Id family of helix-loop-helix proteins in cancer (2005) (281)
- Mad2-induced chromosome instability leads to lung tumor relapse after oncogene withdrawal (2010) (275)
- High incidence of T-cell tumors in E2A-null mice and E2A/Id1 double-knockout mice (1997) (272)
- Effect of angiogenesis inhibition by Id loss and the contribution of bone-marrow-derived endothelial cells in spontaneous murine tumors. (2003) (266)
- ID genes mediate tumor reinitiation during breast cancer lung metastasis (2007) (264)
- Inhibition of myeloid differentiation by the helix-loop-helix protein Id. (1992) (256)
- High levels of Id1 expression define B1 type adult neural stem cells. (2009) (250)
- MAD2 associates with the cyclosome/anaphase-promoting complex and inhibits its activity. (1997) (245)
- The Id proteins and angiogenesis (2001) (232)
- Each member of the Id gene family exhibits a unique expression pattern in mouse gastrulation and neurogenesis (1997) (228)
- Rescue of Cardiac Defects in Id Knockout Embryos by Injection of Embryonic Stem Cells (2004) (215)
- Mitotic checkpoints: from yeast to cancer. (2001) (210)
- TGF-β-Id1 signaling opposes Twist1 and promotes metastatic colonization via a mesenchymal-to-epithelial transition. (2013) (202)
- Complete loss of the tumor suppressor MAD2 causes premature cyclin B degradation and mitotic failure in human somatic cells. (2004) (201)
- Id sustains Hes1 expression to inhibit precocious neurogenesis by releasing negative autoregulation of Hes1. (2007) (201)
- Expression patterns of Id1, Id2, and Id3 are highly related but distinct from that of Id4 during mouse embryogenesis (1996) (195)
- Heterozygous deletion of mitotic arrest-deficient protein 1 (MAD1) increases the incidence of tumors in mice. (2007) (189)
- Mad2 is a critical mediator of the chromosome instability observed upon Rb and p53 pathway inhibition. (2011) (182)
- Bone marrow-derived endothelial progenitor cells contribute to the angiogenic switch in tumor growth and metastatic progression. (2009) (174)
- Bone morphogenetic protein 2 transiently enhances expression of a gene, Id (inhibitor of differentiation), encoding a helix-loop-helix molecule in osteoblast-like cells. (1993) (170)
- Hec1 overexpression hyperactivates the mitotic checkpoint and induces tumor formation in vivo (2008) (151)
- Id1 restrains myeloid commitment, maintaining the self-renewal capacity of hematopoietic stem cells (2007) (147)
- Repression of immunoglobulin enhancers by the helix-loop-helix protein Id: implications for B-lymphoid-cell development (1991) (147)
- Self-renewal does not predict tumor growth potential in mouse models of high-grade glioma. (2012) (138)
- Cancer cells preferentially lose small chromosomes (2013) (134)
- Transcription of the dominant-negative helix-loop-helix protein Id1 is regulated by a protein complex containing the immediate-early response gene Egr-1 (1996) (133)
- Mad2 transiently associates with an APC/p55Cdc complex during mitosis. (1998) (132)
- Id: A Negative Regulator of Helix‐Loop‐Helix DNA Binding Proteins (1990) (129)
- Id proteins synchronize stemness and anchorage to the niche of neural stem cells (2012) (123)
- Mad2 phosphorylation regulates its association with Mad1 and the APC/C (2003) (120)
- Changing Mad2 Levels Affects Chromosome Segregation and Spindle Assembly Checkpoint Control in Female Mouse Meiosis I (2007) (120)
- Peptide-conjugated antisense oligonucleotides for targeted inhibition of a transcriptional regulator in vivo (2008) (114)
- The gene for the helix-loop-helix protein, Id, is specifically expressed in neural precursors. (1992) (112)
- The cancer biology of whole-chromosome instability (2013) (110)
- An intermolecular disulfide bond stabilizes E2A homodimers and is required for DNA binding at physiological temperatures (1994) (108)
- The loop region of the helix-loop-helix protein Id1 is critical for its dominant negative activity (1993) (101)
- Slow-dividing satellite cells retain long-term self-renewal ability in adult muscle (2012) (101)
- Angiogenesis impairment in Id-deficient mice cooperates with an Hsp90 inhibitor to completely suppress HER2/neu-dependent breast tumors (2003) (98)
- Molecular analyses of the mitotic checkpoint components hsMAD2, hBUB1 and hBUB3 in human cancer (2001) (98)
- Nucleosomes are phased along the mouse β-major globin gene in erythroid and nonerythroid cells (1986) (89)
- Reassessment of id1 protein expression in human mammary, prostate, and bladder cancers using a monospecific rabbit monoclonal anti-id1 antibody. (2006) (85)
- Utilization of Bone Marrow-Derived Endothelial Cell Precursors in Spontaneous Prostate Tumors Varies with Tumor Grade (2004) (84)
- Id1 Restrains p21 Expression to Control Endothelial Progenitor Cell Formation (2007) (80)
- Id expression during mouse development: A role in morphogenesis (1992) (71)
- Selective killing of tumor neovasculature paradoxically improves chemotherapy delivery to tumors. (2010) (69)
- Oncogenes and Angiogenesis: down-regulation of thrombospondin-1 in normal fibroblasts exposed to factors from cancer cells harboring mutant ras. (2005) (69)
- Using the transcription factor inhibitor of DNA binding 1 to selectively target endothelial progenitor cells offers novel strategies to inhibit tumor angiogenesis and growth. (2010) (67)
- Id1 maintains embryonic stem cell self-renewal by up-regulation of Nanog and repression of Brachyury expression. (2012) (62)
- Inhibition of neovascularization to simultaneously ameliorate graft-vs-host disease and decrease tumor growth. (2010) (62)
- Mesenchymal high-grade glioma is maintained by the ID-RAP1 axis. (2013) (62)
- Cox-2-derived PGE2 induces Id1-dependent radiation resistance and self-renewal in experimental glioblastoma. (2016) (58)
- Endothelial progenitor cells are cellular hubs essential for neoangiogenesis of certain aggressive adenocarcinomas and metastatic transition but not adenomas (2008) (58)
- Role of Id proteins in embryonic and tumor angiogenesis. (2001) (56)
- Somatic chromosomal engineering identifies BCAN-NTRK1 as a potent glioma driver and therapeutic target (2017) (52)
- Two Isoforms of Protein Disulfide Isomerase Alter the Dimerization Status of E2A Proteins by a Redox Mechanism* (1999) (48)
- Id4 messenger RNA and estrogen receptor expression: inverse correlation in human normal breast epithelium and carcinoma. (2006) (46)
- Cysteine sulfinate aminotransferase and aspartate aminotransferase isoenzymes of rat brain. Purification, characterization, and further evidence for identity. (1980) (39)
- ID1 Is a Functional Marker for Intestinal Stem and Progenitor Cells Required for Normal Response to Injury (2014) (39)
- Enhancer-specific Modulation of E Protein Activity* (2002) (38)
- Id4 protein is highly expressed in triple-negative breast carcinomas: possible implications for BRCA1 downregulation (2012) (38)
- Selective Alpha-Particle Mediated Depletion of Tumor Vasculature with Vascular Normalization (2007) (36)
- Mad2 Overexpression Uncovers a Critical Role for TRIP13 in Mitotic Exit. (2017) (35)
- A Double Edged Sword: MAD2 Dependent Mitotic Checkpoint Defects in Tumorigenesis and Tumor Cell Death (2004) (34)
- MAD2 dependent mitotic checkpoint defects in tumorigenesis and tumor cell death: a double edged sword. (2004) (30)
- Endostatin's endpoints-Deciphering the endostatin antiangiogenic pathway. (2004) (29)
- Celecoxib Alters the Intestinal Microbiota and Metabolome in Association with Reducing Polyp Burden (2016) (28)
- Cyclooxygenase-2-derived Prostaglandin E2 Stimulates Id-1 Transcription* (2008) (27)
- A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization (2019) (27)
- Chromosomal assignment of human ID1 and ID2 genes. (1995) (26)
- Switching-On Survival and Repair Response Programs in Islet Transplants by Bone Marrow–Derived Vasculogenic Cells (2008) (26)
- Regulation of AKT signaling by Id1 controls t(8;21) leukemia initiation and progression. (2015) (26)
- Early Growth Response 1 and NF-ATc1 Act in Concert to Promote Thymocyte Development beyond the β-Selection Checkpoint1 (2007) (24)
- Whole chromosome loss and associated breakage–fusion–bridge cycles transform mouse tetraploid cells (2018) (24)
- The Id proteins: targets for inhibiting tumor cells and their blood supply. (2001) (24)
- Somatic mutations in leukocytes infiltrating primary breast cancers (2015) (23)
- Embryonic stem cells prevent developmental cardiac defects in mice (2006) (22)
- Id-1 is not expressed in the luminal epithelial cells of mammary glands (2003) (19)
- TNF is a key cytokine mediating neutrophil cytotoxic activity in breast cancer patients (2016) (19)
- Differential role of Id1 in MLL-AF9-driven leukemia based on cell of origin. (2016) (18)
- Early growth response 1 and NF-ATc1 act in concert to promote thymocyte development beyond the beta-selection checkpoint. (2007) (18)
- Reassessment of Id 1 Protein Expression in Human Mammary , Prostate , and Bladder Cancers Using a Monospecific Rabbit Monoclonal Anti-Id 1 Antibody (2006) (14)
- Targeting ubiquitin protein ligase E3 component N-recognin 5 in cancer cells induces a CD8+ T cell mediated immune response (2020) (12)
- Expression Patterns of I&, Id2, and Id3 Are Highly Related But Distinct From That of I d 4 During Mouse Embryogenesis (2004) (12)
- Chapter Fifteen – Targeting Protein–Protein Interactions to Treat Cancer—Recent Progress and Future Directions (2013) (11)
- Very CIN-ful: whole chromosome instability promotes tumor suppressor loss of heterozygosity. (2009) (11)
- Id1 Deficiency Protects against Tumor Formation in ApcMin/+ Mice but Not in a Mouse Model of Colitis-Associated Colon Cancer (2015) (11)
- Immunological and organizational heterogeneity of histone H2a variants within chromatin of cells at different stages of Friend leukemia. (1981) (10)
- Polycystins: inhibiting the inhibitors (2005) (10)
- Induction of complete regressions of oncogene-induced breast tumors in mice. (2005) (9)
- Preface: Regulation by Id (2001) (7)
- Id1 expression in endothelial cells of the colon is required for normal response to injury. (2015) (7)
- MAD 2 associates with the cyclosome y anaphase-promoting complex and inhibits its activity ( mitotic checkpoint y spindle assembly checkpoint y cell cycle y mitosis (1997) (6)
- Human B‐like lymphoblastoid cell lines obtained by long‐term culture of normal spleen leukocytes (1984) (5)
- Anti-tumor effects of an ID antagonist with no observed acquired resistance (2021) (5)
- Anti-tumor effects of an Id antagonist with no acquired resistance (2020) (4)
- Grant applications: Undo NIH policy to ease effect of cuts (2013) (3)
- Author Correction: Somatic chromosomal engineering identifies BCAN-NTRK1 as a potent glioma driver and therapeutic target (2018) (3)
- Regional distributions of γ-aminobutyric acid (GABA), glutamate decarboxylase (GAD), and γ-aminobutyrate transaminase (GABA-T) in the central nervous brains of C57/BR, C3H/He, and F1 hybrid mice (1980) (3)
- A genetic approach to understanding tumor angiogenesis. (2002) (3)
- Molecular biology (pre-clinical) (2012) (3)
- Erratum: Mesenchymal high-grade glioma is maintained by the ID-RAP1 axis (The Journal of Clinical Investigation (2013) 123:1 (405-417) (DOI: 10.1172/JCI63811) (2014) (2)
- Id Proteins Contribute to Tumor Development and Metastatic Colonization in a Model of Bladder Carcinogenesis (2015) (2)
- An alternate CSA pathway regulating taurine metabolism? (1981) (2)
- Id1 Regulates the Choice of Hematopoietic Stem Cells to Self-Renew or Commit to Differentiation. (2005) (2)
- Slow-dividing satellite cells retain long-term self-renewal ability in adult muscle (2012) (2)
- Torsional properties of DNA in chromatin. (1985) (2)
- Impact of circulating endothelial progenitor cells on the growth of viable tumor rim after treatment with a vascular disrupting agent. (2006) (1)
- Regional distributions of gamma-aminobutyric acid (GABA), glutamate decarboxylase (GAD), and gamma-aminobutyrate transaminase (GABA-T) in the central nervous brains of C57/BR, C3H/He, and F1 hybrid mice. (1980) (1)
- Depletion of Vascular Endothelial Progenitor Cells Simultaneously Ameliorates GVHD and Inhibits Tumor Growth (2009) (1)
- Id proteins sustain Hes1 expression to maintain neural stem cells (2008) (1)
- Endothelial Biomedicine: Id Proteins and Angiogenesis (2007) (1)
- Stimulates 2 Cyclooxygenase-2-derived Prostaglandin E Mechanisms of Signal Transduction : (2008) (0)
- Mapping the structure of macromolecular assemblies by combining chemical modification and separation methods (1985) (0)
- Correction (2013) (0)
- Depletion of Vascular Endothelial Progenitor Cells Inhibits Inflammation (2008) (0)
- The novel cytotoxicity of neutrophils in the peripheral blood of breast cancer patients versus women without breast cancer. (2011) (0)
- The novel cytotoxicity of neutrophils in the peripheral blood of patients with breast cancer versus healthy women. (2011) (0)
- Vascular Endothelial-Cadherin Targeted Alpha-Particle Mediated Vascular Killing and Remodeling Augments Subsequent Chemotherapeutic Efficacy. (2009) (0)
- Gene-expression profiling to demonstrate select neutrophils from breast cancer patients versus healthy women as cytotoxic against breast cancer cells via novel chemokine-mediated mechanisms. (2014) (0)
- An Appreciation (1949) (0)
- Abstract 1415: Anti-metastatic properties of tumor-entrained neutrophils (2012) (0)
- Targeting ID to Inhibit the Vascularization of Breast Tumors (2001) (0)
- BTC Retreat - Tuesday, May 15 th , 2012 - MSKCC RRL-Auditorium (2012) (0)
- Abstract P5-01-07: Select neutrophils inhibit breast cancer metastases in patients via chemokine-mediated mechanisms (2013) (0)
- 1: Chemokine networks regulate the balance of pro-and anti-tumor granulocytes that determine metastatic progression in breast cancer models (2013) (0)
- Modeling Blood Vessel Formation in the Mouse (2004) (0)
- The use of a plasma protein fraction in culture of human spleen leukocytes during induction of interferon (1984) (0)
- Dr R Benezra (2001) (0)
- Using Transcription Factor Id1 to Selectively Target Endothelial Progenitor Cells Offers Novel Strategies to Inhibit Tumor Angiogenesis and Growth (2010) (0)
- TMOD-11. MODELING AND TARGETING KIAA1549-BRAF DRIVEN CNS TUMORS (2019) (0)
- The effect of mitotic checkpoint defects on chromosome stability in mammals (2005) (0)
- Identifying somatic oncogenic mutations in leukocytes that infiltrate primary breast cancers. (2015) (0)
- 100%FiO2 Supplemental Oxygen for Traumatic Pneumocephalus Without Evidence of Fracture on Serial CT Scan of the Head (2019) (0)
- The cytotoxicity of select neutrophils in breast cancer patients and the role of chemokines in neutrophil cytotoxicity. (2013) (0)
- CYSTEINE SULFINATE TRANSAMINASES AND ASPARTATE AMINOTRANSFERASES OF RAT BRAIN. PURIFICATION, PROPERTIES AND ROLE (1980) (0)
- P1-01-03: The Cytotoxicity of Select Neutrophils in Cancer Patients and the Role of Chemokines in Inducing Neutrophil Cytotoxicity. (2011) (0)
- Gene encoding the human homolog of MAD2 (1997) (0)
- Mad2 (Mitotic Arrest Deficiency 2) Is Essential for the Synergistic Proliferation Induced by Stem Cell Factor Combined with GM-CSF in Hematopoietic Progenitor Cells, Effects Reflecting the Association of c-kit with Mad2. (2005) (0)
- Cancer esearch apeutics , Targets , and Chemical Biology ctive Killing of Tumor Neovasculature Paradoxically R roves Chemotherapy Delivery to Tumors (2010) (0)
- Whole chromosome loss in tetraploid cells confers tumorigenic potential in a mouse allograft model (2017) (0)
- Immunohistochemical analyses for Id-1 in mouse mammary glands during various phases of development (2011) (0)
- determinant of nascent tumor neovascularization Bone marrow-derived endothelial progenitor cells are a major Material Supplemental (2007) (0)
- Helix-Loop-helix motif of mouse DNA-binding protein inhibitor ID-1 (2019) (0)
- tegies to Inhibit Tumor Angiogenesis and Growth (2010) (0)
- Role of Id proteins in tumor angiogenesis (2002) (0)
- Abstract 2367A: Understanding the role of stem-like tumor cells in mouse models of high-grade gliomas (2012) (0)
- Anti-tumor effects of an ID antagonist with no observed acquired resistance (2021) (0)
- mouse Id1 (51-104) - human hE47 (348-399) complex (2019) (0)
- MYELOID NEOPLASIA Regulation of AKT signaling by Id1 controls t(8;21) leukemia initiation and progression (2016) (0)
- Mitosis: Chromosome Segregation and Stability (2006) (0)
- 97P The Role of Id Proteins in the Induction of Tumor-Initiating Cells During Pulmonary Colonization of Metastatic Breast Cancer (2012) (0)
- Checkpoint-Selection β Development beyond the in Concert to Promote Thymocyte Early Growth Response 1 and NF-ATc 1 Act (2007) (0)
- TheLoopRegion oftheHelix-Loop-Helix Protein IdlIs Critical forItsDominant Negative Activity (1993) (0)
- Monospecific Rabbit Monoclonal Anti-Id 1 Antibody Mammary , Prostate , and Bladder Cancers Using a Reassessment of Id 1 Protein Expression in Human (2006) (0)
- LAB-STEM CELLS (2012) (0)
- Expression of Id 1 Protein in Developing Retinal Vasculature (2005) (0)
- Identification of Key Cellular Regulators That Interact with Id1 To Control Hematopoietic Stem Cell Behavior. (2006) (0)
- Withdrawal: Cyclooxygenase-2-derived prostaglandin E2 stimulates Id-1 transcription. (2020) (0)
- AGX51, a potential anti-tumour therapy targeting ID proteins (2021) (0)
- Withdrawal: Cyclooxygenase-2-derived prostaglandin E2 stimulates Id-1 transcription. (2020) (0)
- Abstract PD1-4: Somatic leukemogenic mutations associated with infiltrating white blood cells in breast cancer patients (2015) (0)
- Abstract CN07-01: Understanding the role of stem-like tumor cells in proneural glioma (2012) (0)
- #662 Taxol induces wide-spread necrosis in rhabdomyosarcoma (1997) (0)
- Retraction: Id1 Deficiency Protects Against Tumor Formation in ApcMin/+ Mice but not in a Mouse Model of Colitis-associated Colon Cancer. (2022) (0)
- Abstract 4975: A small molecule pan Id protein antagonist shows strong antitumor activity (2017) (0)
- MS1-2: Tumor Entrained Neutrophils Inhibit Seeding in the Pre-Metastatic Lung. (2011) (0)
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