Robert H. Silverman

Robert H. Silverman's AcademicInfluence.com Rankings

Robert H. Silverman

Biology

#8364

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#11429

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Molecular Biology

#1055

World Rank

#1079

Historical Rank

biology Degrees

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Biology

Robert H. Silverman's Degrees

PhD Molecular Biology University of California, Berkeley
Bachelors Biology Stanford University

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Robert H. Silverman's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

How cells respond to interferons. (1998) (4172)
Identification of genes differentially regulated by interferon α, β, or γ using oligonucleotide arrays (1998) (1679)
Activation of the interferon system by short-interfering RNAs (2003) (1494)
Interferons at age 50: past, current and future impact on biomedicine (2007) (1093)
Identification of genes differentially regulated by interferon alpha, beta, or gamma using oligonucleotide arrays. (1998) (941)
Functional classification of interferon‐stimulated genes identified using microarrays (2001) (899)
Apoptosis and interferons: Role of interferon-stimulated genes as mediators of apoptosis (2003) (811)
Small self-RNA generated by RNase L amplifies antiviral innate immunity (2007) (619)
Tat trans-activates the human immunodeficiency virus through a nascent RNA target (1989) (607)
Identification of a Novel Gammaretrovirus in Prostate Tumors of Patients Homozygous for R462Q RNASEL Variant (2006) (589)
Viral Encounters with 2′,5′-Oligoadenylate Synthetase and RNase L during the Interferon Antiviral Response (2007) (576)
Interferon action and apoptosis are defective in mice devoid of 2′,5′‐oligoadenylate‐dependent RNase L (1997) (547)
Expression cloning of 2-5A-dependent RNAase: A uniquely regulated mediator of interferon action (1993) (507)
The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule (2012) (462)
Alphavirus-based DNA vaccine breaks immunological tolerance by activating innate antiviral pathways (2003) (287)
New insights into the role of RNase L in innate immunity. (2011) (271)
Specific phenotypic restoration of an attenuated virus by knockout of a host resistance gene. (2000) (261)
2-5A-dependent RNase Molecules Dimerize during Activation by 2-5A (*) (1995) (259)
Antagonism of the Interferon-Induced OAS-RNase L Pathway by Murine Coronavirus ns2 Protein Is Required for Virus Replication and Liver Pathology (2012) (258)
Interferon action in triply deficient mice reveals the existence of alternative antiviral pathways. (1999) (257)
PKR and RNase L Contribute to Protection against Lethal West Nile Virus Infection by Controlling Early Viral Spread in the Periphery and Replication in Neurons (2006) (252)
Blockage of NF-kappa B signaling by selective ablation of an mRNA target by 2-5A antisense chimeras. (1994) (224)
An infectious retrovirus susceptible to an IFN antiviral pathway from human prostate tumors (2007) (220)
Ribosomal RNA cleavage, nuclease activation and 2-5A(ppp(A2'p)nA) in interferon-treated cells. (1981) (216)
Activation of p38 Mitogen-Activated Protein Kinase and c-Jun NH2-Terminal Kinase by Double-Stranded RNA and Encephalomyocarditis Virus: Involvement of RNase L, Protein Kinase R, and Alternative Pathways (2000) (210)
ISG20, a New Interferon-induced RNase Specific for Single-stranded RNA, Defines an Alternative Antiviral Pathway against RNA Genomic Viruses* (2003) (205)
Radioimmune, radiobinding and HPLC analysis of 2-5A and related oligonucleotides from intact cells (1980) (196)
RNASEL Arg462Gln variant is implicated in up to 13% of prostate cancer cases (2002) (189)
Blockade of Interferon Induction and Action by the E3L Double-Stranded RNA Binding Proteins of Vaccinia Virus (2002) (186)
Targeted therapy of human malignant glioma in a mouse model by 2-5A antisense directed against telomerase RNA (1998) (183)
Nucleoside modifications in RNA limit activation of 2′-5′-oligoadenylate synthetase and increase resistance to cleavage by RNase L (2011) (183)
The role of 2′-5′ oligoadenylate-activated ribonuclease L in apoptosis (1998) (183)
Effects of RNase L mutations associated with prostate cancer on apoptosis induced by 2',5'-oligoadenylates. (2003) (178)
Activation of RNase L is dependent on OAS3 expression during infection with diverse human viruses (2016) (176)
Implications for RNase L in prostate cancer biology. (2003) (175)
Early endonuclease-mediated evasion of RNA sensing ensures efficient coronavirus replication (2017) (171)
West Nile Virus Noncoding Subgenomic RNA Contributes to Viral Evasion of the Type I Interferon-Mediated Antiviral Response (2012) (169)
Intrinsic molecular activities of the interferon-induced 2-5A-dependent RNase. (1994) (156)
RNase L Plays a Role in the Antiviral Response to West Nile Virus (2006) (152)
Respiratory syncytial virus induces interleukin-10 by human alveolar macrophages. Suppression of early cytokine production and implications for incomplete immunity. (1995) (150)
HIV-1 TAR RNA has an intrinsic ability to activate interferon-inducible enzymes. (1994) (146)
RNase L releases a small RNA from HCV RNA that refolds into a potent PAMP. (2010) (144)
Herpes simplex virus infection is sensed by both Toll-like receptors and retinoic acid-inducible gene- like receptors, which synergize to induce type I interferon production. (2009) (134)
An Apoptotic Signaling Pathway in the Interferon Antiviral Response Mediated by RNase L and c-Jun NH2-terminal Kinase* (2004) (131)
Cytosolic Double-Stranded RNA Activates the NLRP3 Inflammasome via MAVS-Induced Membrane Permeabilization and K+ Efflux (2014) (126)
Activation of interferon-regulated, dsRNA-dependent enzymes by human immunodeficiency virus-1 leader RNA. (1989) (124)
rRNA cleavage as an index of ppp(A2'p)nA activity in interferon-treated encephalomyocarditis virus-infected cells (1983) (122)
Functional Replacement of the Carboxy-Terminal Two-Thirds of the Influenza A Virus NS1 Protein with Short Heterologous Dimerization Domains (2002) (121)
Integration Site Preference of Xenotropic Murine Leukemia Virus-Related Virus, a New Human Retrovirus Associated with Prostate Cancer (2008) (120)
Interferon-Regulated Pathways That Control Hepatitis B Virus Replication in Transgenic Mice (2002) (119)
Homologous 2′,5′-phosphodiesterases from disparate RNA viruses antagonize antiviral innate immunity (2013) (116)
Middle East Respiratory Syndrome Coronavirus NS4b Protein Inhibits Host RNase L Activation (2016) (116)
A scientific journey through the 2-5A/RNase L system. (2007) (115)
A Bipartite Model of 2-5A-dependent RNase L* (1997) (114)
RNase L activates the NLRP3 inflammasome during viral infections. (2015) (113)
RNA-Dependent Protein Kinase PKR Is Required for Activation of NF-κB by IFN-γ in a STAT1-Independent Pathway1 (2001) (113)
Dimeric Structure of Pseudokinase RNase L Bound to 2-5A Reveals a Basis for Interferon-Induced Antiviral Activity (2014) (111)
Phospholipid Scramblase 1 Potentiates the Antiviral Activity of Interferon (2004) (108)
Control of the ppp(a2'p)nA system in HeLa cells. Effects of interferon and virus infection. (1982) (105)
Targeting RNA for degradation with a (2'-5')oligoadenylate-antisense chimera. (1993) (105)
RNase L and Double-Stranded RNA-Dependent Protein Kinase Exert Complementary Roles in Islet Cell Defense during Coxsackievirus Infection1 (2005) (100)
Inflammation, infection, and prostate cancer (2008) (100)
Diverse functions of RNase L and implications in pathology. (2007) (99)
Fascination with 2-5A-dependent RNase: a unique enzyme that functions in interferon action. (1994) (98)
Direct evidence for translational regulation by leader RNA and Tat protein of human immunodeficiency virus type 1. (1990) (94)
Differential regulation of PTEN expression by androgen receptor in prostate and breast cancers (2011) (92)
Activation of IFN-β expression by a viral mRNA through RNase L and MDA5 (2011) (90)
Ribonuclease L mediates the cell-lethal phenotype of double-stranded RNA editing enzyme ADAR1 deficiency in a human cell line (2017) (90)
Resveratrol regulates the PTEN/AKT pathway through androgen receptor-dependent and -independent mechanisms in prostate cancer cell lines (2010) (90)
2-5A-Dependent RNase L: A Regulated Endoribonuclease in the Interferon System (1997) (89)
Small-molecule activators of RNase L with broad-spectrum antiviral activity (2007) (84)
Fibrils of Prostatic Acid Phosphatase Fragments Boost Infections with XMRV (Xenotropic Murine Leukemia Virus-Related Virus), a Human Retrovirus Associated with Prostate Cancer (2009) (81)
The human retrovirus XMRV in prostate cancer and chronic fatigue syndrome (2010) (79)
Impact of RNase L overexpression on viral and cellular growth and death. (1998) (79)
A Phylogenetically Conserved RNA Structure in the Poliovirus Open Reading Frame Inhibits the Antiviral Endoribonuclease RNase L (2007) (76)
SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial-derived cells and cardiomyocytes (2021) (75)
Effect of deficiency of the double-stranded RNA-dependent protein kinase, PKR, on antiviral resistance in the presence or absence of ribonuclease L: HSV-1 replication is particularly sensitive to deficiency of the major IFN-mediated enzymes. (2000) (74)
Inhibition of RNase L and RNA-dependent Protein Kinase (PKR) by Sunitinib Impairs Antiviral Innate Immunity* (2011) (74)
Purification and analysis of murine 2-5A-dependent RNase. (1988) (74)
Involvement of the Interferon-Regulated Antiviral Proteins PKR and RNase L in Reovirus-Induced Shutoff of Cellular Translation (2005) (73)
Differential Effect of Murine Alpha/Beta Interferon Transgenes on Antagonization of Herpes Simplex Virus Type 1 Replication (2002) (73)
A transcriptional signaling pathway in the IFN system mediated by 2'-5'-oligoadenylate activation of RNase L. (2006) (73)
2-5A antisense directed against telomerase RNA produces apoptosis in ovarian cancer cells. (2000) (73)
Affinity labelling and characterization of the ppp(A2'p)nA-dependent endoribonuclease from different mammalian sources. (2005) (71)
Type I interferon inhibits antibody responses induced by a chimpanzee adenovirus vector. (2007) (69)
HPC1/RNASEL Mediates Apoptosis of Prostate Cancer Cells Treated with 2′,5′-Oligoadenylates, Topoisomerase I Inhibitors, and Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (2004) (68)
Down-Regulation of p53 by Double-Stranded RNA Modulates the Antiviral Response (2005) (67)
SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial derived cells and cardiomyocytes (2020) (67)
Transcriptional control of the human plasma membranephospholipid scramblase 1 gene is mediated by interferon-α (2000) (66)
Viral phosphodiesterases that antagonize double-stranded RNA signaling to RNase L by degrading 2-5A. (2014) (65)
Regulation of Human Immunodeficiency Virus Replication by 2′,5′-Oligoadenylate-Dependent RNase L (1998) (65)
Regulation of ppp(A2'p)nA-dependent RNase levels during interferon treatment and cell differentiation. (1985) (65)
The ppp(A2'p)nA and protein kinase systems in wild-type and interferon-resistant Daudi cells. (2005) (65)
RNase L Triggers Autophagy in Response to Viral Infections (2012) (65)
Induction of ppp(A2'p)nA-dependent RNase in murine JLS-V9R cells during growth inhibition. (1983) (64)
Critical Role for the Oligoadenylate Synthetase/RNase L Pathway in Response to IFN-β during Acute Ocular Herpes Simplex Virus Type 1 Infection1 (2005) (63)
Targeting RNA decay with 2',5' oligoadenylate-antisense in respiratory syncytial virus-infected cells. (1997) (63)
Suppression of antiviral innate immunity by sunitinib enhances oncolytic virotherapy. (2013) (63)
Increased severity of HSV-1 keratitis and mortality in mice lacking the 2-5A-dependent RNase L gene. (2001) (63)
Evasion of Antiviral Innate Immunity by Theiler's Virus L* Protein through Direct Inhibition of RNase L (2013) (62)
Synthesis, characterization and properties of ppp(A2'p)nApCp and related high-specific-activity 32P-labelled derivatives of ppp(A2'p)nA. (2005) (61)
A mammalian 2-5A system functions as an antiviral pathway in transgenic plants. (1996) (61)
Sensitivity of hepatitis C virus RNA to the antiviral enzyme ribonuclease L is determined by a subset of efficient cleavage sites. (2004) (60)
Hepatitis C virus RNA: dinucleotide frequencies and cleavage by RNase L. (2007) (60)
Selection and cloning of poly(rC)-binding protein 2 and Raf kinase inhibitor protein RNA activators of 2′,5′-oligoadenylate synthetase from prostate cancer cells (2006) (59)
Suppression of ovarian carcinoma cell growth in vivo by the interferon-inducible plasma membrane protein, phospholipid scramblase 1. (2002) (59)
The murine double-stranded RNA-dependent protein kinase PKR and the murine 2',5'-oligoadenylate synthetase-dependent RNase L are required for IFN-beta-mediated resistance against herpes simplex virus type 1 in primary trigeminal ganglion culture. (2003) (59)
Material for Detection of an Infectious Retrovirus , XMRV , in Blood Cells of Patients with Chronic Fatigue Syndrome (2009) (57)
The antiviral enzymes PKR and RNase L suppress gene expression from viral and non-viral based vectors. (1999) (57)
RNase L Mediates Transient Control of the Interferon Response through Modulation of the Double-stranded RNA-dependent Protein Kinase PKR* (2003) (56)
A viral RNA competitively inhibits the antiviral endoribonuclease domain of RNase L. (2008) (55)
Regulation of interferon‐α‐inducible cellular genes in human immunodeficiency virus‐infected monocytes (1994) (53)
Determinants of protection among HIV‐exposed seronegative persons: an overview. (2010) (52)
Partial retraction. Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome. (2011) (52)
RNase L Mediated Protection from Virus Induced Demyelination (2009) (52)
Cell-Type-Specific Activation of the Oligoadenylate Synthetase–RNase L Pathway by a Murine Coronavirus (2013) (51)
Ribonuclease L and metal-ion–independent endoribonuclease cleavage sites in host and viral RNAs (2014) (50)
The Vaccinia Virus A18R DNA Helicase Is a Postreplicative Negative Transcription Elongation Factor (1998) (50)
RNase L restricts the mobility of engineered retrotransposons in cultured human cells (2013) (50)
Functional analysis of 2-5A-dependent RNase and 2-5a using 2',5'-oligoadenylate-cellulose. (1985) (49)
Interferon-β suppresses herpes simplex virus type 1 replication in trigeminal ganglion cells through an RNase L-dependent pathway (2003) (49)
A transcriptional signaling pathway in the IFN system mediated by 2′-5′-oligoadenylate activation of RNase L (2005) (49)
The Flvr-encoded murine oligoadenylate synthetase 1b (Oas1b) suppresses 2-5A synthesis in intact cells. (2011) (49)
Xenotropic murine leukemia virus-related virus is susceptible to AZT. (2010) (47)
Interferon-α-induced Expression of Phospholipid Scramblase 1 through STAT1 Requires the Sequential Activation of Protein Kinase Cδ and JNK* (2005) (47)
RNase L-Independent Specific 28S rRNA Cleavage in Murine Coronavirus-Infected Cells (2000) (47)
Interferon-induced synthesis of 2-5A-dependent RNase in mouse JLS-V9R cells. (1983) (46)
Mapping of the human RNASEL promoter and expression in cancer and normal cells. (2005) (46)
The search for guanosine tetraphosphate (ppGpp) and other unusual nucleotides in eucaryotes. (1979) (46)
Characterization of antibodies elicited by XMRV infection and development of immunoassays useful for epidemiologic studies (2010) (45)
In-Depth Investigation of Archival and Prospectively Collected Samples Reveals No Evidence for XMRV Infection in Prostate Cancer (2012) (44)
Cloning of murine gelsolin and its regulation during differentiation of embryonal carcinoma cells. (1989) (44)
Role of 2-5A-dependent RNase-L in senescence and longevity (2007) (43)
RNase L downmodulation of the RNA-binding protein, HuR, and cellular growth (2009) (43)
[28] Radioimmune and radiobinding assays for A2′p5′A2′p5′A, pppA2′p5′A2′p5′A, and related oligonucleotides (1981) (42)
Cell-Type-Specific Effects of RNase L on Viral Induction of Beta Interferon (2014) (42)
COVID-19: Coronavirus replication, pathogenesis, and therapeutic strategies. (2020) (42)
Photochemical crosslinking in oligonucleotide-protein complexes between a bromine-substituted 2-5A analog and 2-5A-dependent RNase by ultraviolet lamp or laser. (1990) (41)
Alphavirus Minus-Strand Synthesis and Persistence in Mouse Embryo Fibroblasts Derived from Mice Lacking RNase L and Protein Kinase R (2003) (41)
Infection, Viral Dissemination, and Antibody Responses of Rhesus Macaques Exposed to the Human Gammaretrovirus XMRV (2011) (40)
RNase L Targets Distinct Sites in Influenza A Virus RNAs (2014) (40)
Reverse Signaling through Membrane-bound Interleukin-15* (2004) (39)
OAS-RNase L innate immune pathway mediates the cytotoxicity of a DNA-demethylating drug (2019) (39)
Androgen Stimulates Transcription and Replication of Xenotropic Murine Leukemia Virus-Related Virus (2009) (37)
Genetic susceptibility and oxidative stress in prostate cancer: integrated model with implications for prevention. (2006) (37)
Protein Kinase R-dependent Regulation of Interleukin-10 in Response to Double-stranded RNA* (2008) (37)
Catalytic Cleavage of an RNA Target by 2–5A Antisense and RNase L (*) (1995) (36)
Murine AKAP7 Has a 2′,5′-Phosphodiesterase Domain That Can Complement an Inactive Murine Coronavirus ns2 Gene (2014) (36)
A convenient and sensitive fluorescence resonance energy transfer assay for RNase L and 2',5' oligoadenylates. (2005) (34)
Transcriptional control of the human plasma membrane phospholipid scramblase 1 gene is mediated by interferon-alpha. (2000) (34)
Activation of RNase L by Murine Coronavirus in Myeloid Cells Is Dependent on Basal Oas Gene Expression and Independent of Virus-Induced Interferon (2016) (33)
Targeted therapy of respiratory syncytial virus in African green monkeys by intranasally administered 2-5A antisense. (2002) (33)
Interferon-alpha-induced expression of phospholipid scramblase 1 through STAT1 requires the sequential activation of protein kinase Cdelta and JNK. (2005) (31)
RNase L is a negative regulator of cell migration (2015) (31)
Chemistry and biochemistry of 2',5'-oligoadenylate-based antisense strategy. (2001) (31)
Recruiting the 2-5A system for antisense therapeutics. (1997) (30)
Tumour suppressor function of RNase L in a mouse model. (2007) (27)
Formation of tubuloreticular inclusions in human lymphoma cells compared to the induction of 2'-5'-oligoadenylate synthetase by leucocyte interferon in dose-effect and kinetic studies. (1984) (27)
Distinctive Roles for 2′,5′-Oligoadenylate Synthetases and Double-Stranded RNA-Dependent Protein Kinase R in the In Vivo Antiviral Effect of an Adenoviral Vector Expressing Murine IFN-β1 (2004) (27)
A Decade of Deuteration in Medicinal Chemistry (2017) (26)
A novel mechanism of RNase L inhibition: Theiler's virus L* protein prevents 2-5A from binding to RNase L (2018) (26)
Interferon-induced 2'-5' oligoadenylate synthetase during interferon-alpha therapy in homosexual men with Kaposi's sarcoma: marked deficiency in biochemical response to interferon in patients with acquired immunodeficiency syndrome. (1985) (25)
IFNL4-ΔG Allele Is Associated with an Interferon Signature in Tumors and Survival of African-American Men with Prostate Cancer (2018) (25)
The antiviral action of interferon. (1982) (24)
Zika Virus Production Is Resistant to RNase L Antiviral Activity (2019) (24)
Structural Basis for 2′-5′-Oligoadenylate Binding and Enzyme Activity of a Viral RNase L Antagonist (2015) (23)
Localization of the interferon-induced, 2-5A-dependent RNase gene (RNS4) to human chromosome 1q25. (1994) (23)
Sexual Transmission of XMRV: A Potential Infection Route (2011) (23)
Inhibition of human parainfluenza virus type 3 infection by novel small molecules. (2008) (23)
Antisense cancer therapy: The state of the science (2000) (22)
Role of Ribonuclease L in Viral Pathogen-Associated Molecular Pattern/Influenza Virus and Cigarette Smoke–Induced Inflammation and Remodeling (2013) (22)
Reverse signaling through membrane-bound interleukin-15. (2011) (22)
Skin allograft rejection is suppressed in mice lacking the antiviral enzyme, 2',5'-oligoadenylate-dependent RNase L. (2002) (22)
Independent regulation of ppp(A2'p)nA-dependent RNase in NIH 3T3, clone 1 cells by growth arrest and interferon treatment. (1985) (22)
244 (2013) (22)
2',5'-Oligoadenylate-antisense chimeras cause RNase L to selectively degrade bcr/abl mRNA in chronic myelogenous leukemia cells. (1998) (21)
Lineage A Betacoronavirus NS2 Proteins and the Homologous Torovirus Berne pp1a Carboxy-Terminal Domain Are Phosphodiesterases That Antagonize Activation of RNase L (2016) (21)
Reverse Genetics Reveals a Role of Rotavirus VP3 Phosphodiesterase Activity in Inhibiting RNase L Signaling and Contributing to Intestinal Viral Replication In Vivo (2020) (21)
The xenotropic murine leukemia virus-related retrovirus debate continues at first international workshop (2010) (21)
RNase-L Deficiency Exacerbates Experimental Colitis and Colitis-associated Cancer (2013) (21)
Activation of 2-5A-dependent RNase by analogs of 2-5A (5'-O-triphosphoryladenylyl(2'----5')adenylyl(2'----5')adenosine ) using 2',5'-tetraadenylate (core)-cellulose. (1986) (21)
Xenotropic murine leukemia virus–related virus (XMRV) and blood transfusion: report of the AABB interorganizational XMRV task force (2011) (20)
A Natural Human Retrovirus Efficiently Complements Vectors Based on Murine Leukemia Virus (2008) (19)
Elevated levels of 2',5'-linked oligoadenylate-dependent ribonuclease L occur as an early event in colorectal tumorigenesis. (1995) (19)
RNA-Dependent Protein Kinase Is Required for Alpha-1 Interferon Transgene-Induced Resistance to Genital Herpes Simplex Virus Type 2 (2005) (18)
Synthesis of a 5′-thiophosphate analogue of 2-5A, a phosphatase resistant activator of the 2-5A-dependent ribonuclease (1994) (18)
Fidelity of Target Site Duplication and Sequence Preference during Integration of Xenotropic Murine Leukemia Virus-Related Virus (2010) (18)
Absence of PKR attenuates the anti-HSV-1 activity of an adenoviral vector expressing murine IFN-beta. (2002) (17)
Pathological aggressiveness of prostatic carcinomas related to RNASEL R462Q allelic variants. (2008) (17)
Absence of XMRV and Closely Related Viruses in Primary Prostate Cancer Tissues Used to Derive the XMRV-Infected Cell Line 22Rv1 (2012) (17)
Stress responses: Translational control perks up (1999) (17)
Analysis and origins of the human and mouse RNase L genes: mediators of interferon action (2000) (16)
Nuclease-resistant composite 2',5'-oligoadenylate-3', 5'-oligonucleotides for the targeted destruction of RNA: 2-5A-iso-antisense. (1998) (15)
Translational regulation by HIV leader RNA, TAT, and interferon-inducible enzymes. (1990) (15)
Suppressing PARylation by 2′,5′‐oligoadenylate synthetase 1 inhibits DNA damage‐induced cell death (2020) (14)
Detection of an Infectious Retrovirus, XMRV, in Blood Cells of Patients with Chronic Fatigue Syndrome (2009) (13)
Partial Retraction (2011) (13)
Analysis of Single-Nucleotide Polymorphisms in Patient-Derived Retrovirus Integration Sites Reveals Contamination from Cell Lines Acutely Infected by Xenotropic Murine Leukemia Virus-Related Virus (2011) (12)
Inborn errors of OAS–RNase L in SARS-CoV-2–related multisystem inflammatory syndrome in children (2022) (12)
RNase L activity does not contribute to host RNA degradation induced by herpes simplex virus infection. (2003) (12)
Assay of (2'-5')-oligo(A) synthesized in vitro and the analysis of naturally occurring (2'-5')-oligo(A) from intact cells. (1981) (12)
Ribonuclease L is not critical for innate restriction and adaptive immunity against Friend retrovirus infection. (2013) (12)
Correlation of selective modifications to a 2',5'-oligoadenylate-3',5'-deoxyribonucleotide antisense chimera with affinity for the target nucleic acid and with ability to activate RNase L. (1997) (11)
Activation of RNase L in Egyptian Rousette Bat-Derived RoNi/7 Cells Is Dependent Primarily on OAS3 and Independent of MAVS Signaling (2019) (11)
A phenolic small molecule inhibitor of RNase L prevents cell death from ADAR1 deficiency (2020) (11)
Proteasome-mediated degradation of RNase L in response to phorbol-12-myristate-13-acetate (PMA) treatment of mouse L929 cells. (2003) (11)
Dichotomy between survival and lytic gene expression in RNase L- and PKR-deficient mice transduced with an adenoviral vector expressing murine IFN-beta following ocular HSV-1 infection. (2005) (11)
Tunicamycin enhances the antiviral and anticellular activity of interferon. (1983) (10)
Synthesis, characterization, and biological properties of 8-azido- and 8-amino-substituted 2',5'-oligoadenylates. (2003) (10)
OAS and PKR are not required for the antiviral effect of Ad:IFN-gamma against acute HSV-1 in primary trigeminal ganglia cultures. (2006) (10)
Delivery of 2-5A cargo into living cells using the Tat cell penetrating peptide: 2-5A-tat. (2006) (9)
Unusual effects of 5a,6-anhydrotetracycline and other tetracyclines. Inhibition of guanosine 5'-diphosphate 3'-diphosphate metabolism, RNA accumulation and other growth-related processes in Escherichia coli. (1978) (9)
The 2-5A system. Molecular and clinical aspects of the interferon-regulated pathway. Proceedings of the Sixth International Symposium of the Research Institute, Hospital for Sick Children. Toronto, Ontario, Canada, June 305, 1985. (1985) (9)
Tissue-related and species-specific differences in the 2-5A oligomer size requirement for activation of 2-5A-dependent RNase. (1993) (8)
No Biological Evidence of XMRV in Blood or Prostatic Fluid from Prostate Cancer Patients (2012) (8)
The 2-5A (pppA2'p5'A2'p5'A) and protein kinase systems in interferon-treated and control cells. (1981) (8)
Murine AKAP 7 Has a 2 = , 5 =-Phosphodiesterase Domain That Can Complement an Inactive Murine Coronavirus ns 2 Gene (2014) (7)
In vivo hypermutation of xenotropic murine leukemia virus-related virus DNA in peripheral blood mononuclear cells of rhesus macaque by APOBEC3 proteins. (2011) (7)
Mouse embryos fail to synthesize detectable quantities of guanosine 5'-diphosphate 3'-diphosphate. (1977) (7)
Putting the brakes on the unfolded protein response (2011) (7)
The lack of RNA‐dependent protein kinase enhances susceptibility of mice to genital herpes simplex virus type 2 infection (2006) (7)
2-5A Ligands—A New Concept for the Treatment of Prostate Cancer (2007) (7)
2′,5′-Oligoadenylate Antisense Chimeras for Targeted Ablation of RNA (1994) (6)
An alternative spliced RNASEL variant in peripheral blood leukocytes. (2006) (6)
Suppressing PARylation by 2′,5′‐oligoadenylate synthetase 1 inhibits DNA damage‐induced cell death (2020) (6)
Human telomerase RNA degradation by 2'-5'-linked oligoadenylate antisense chimeras in a cell-free system, cultured tumor cells, and murine xenograft models. (2006) (6)
3-Deazaadenosine analogues of p5'A2'p5'A2'p5'A: synthesis, stereochemistry, and the roles of adenine ring nitrogen-3 in the interaction with RNase L. (2004) (6)
A RADIOIMMUNOASSAY FOR ppGpp (1979) (5)
The 2-5A system in control and interferon-treated K/BALB cells infected with encephalomyocarditis virus. (1985) (5)
Interferon and 2-5A synthetase in patients with immune diseases. (1985) (5)
Origins of Programming: Discourses on Methodology (1990) (5)
H3K9 methylation drives resistance to androgen receptor–antagonist therapy in prostate cancer (2022) (5)
Endowing RNase H-inactive antisense with catalytic activity: 2-5A-morphants. (2005) (5)
Specificity and Mechanism of Coronavirus, Rotavirus and Mammalian Two-Histidine-Phosphoesterases That Antagonize Antiviral Innate Immunity (2021) (5)
On the role of the divalent metal ion in the methylaspartate ammonia-lyase reaction (1964) (4)
2-Bromoadenosine-substituted 2',5'-oligoadenylates modulate binding and activation abilities of human recombinant rnase L (1998) (4)
Radioimmune and radiobinding assays for A2'p5'A2'p5'A, pppA2'p5'A, and related oligonucleotides. (1981) (4)
Zika virus employs the host antiviral RNase L protein to support replication factory assembly (2021) (4)
Caps off to poxviruses. (2015) (4)
Involvement of the 2'-5' A pathway in the augmentation of natural killer activity. (1987) (4)
Crystal structure of the mouse hepatitis virus ns2 phosphodiesterase domain that antagonizes RNase L activation. (2016) (4)
XMRV Discovery and Prostate Cancer-Related Research (2011) (4)
Retraction: Identification of a Novel Gammaretrovirus in Prostate Tumors of Patients Homozygous for R462Q RNASEL Variant (2012) (3)
Role of Oligoadenylate Synthetases in Myeloid Neoplasia (2020) (3)
239: Identification of a Novel Retrovirus in Prostate Tumors of Patients Homozygous for the R462Q Mutation in the HPC1 Gene (2006) (3)
Identification of Small Molecule Inhibitors of RNase L by Fragment-Based Drug Discovery. (2021) (3)
244 Homologous 2′,5′-phosphodiesterases from disparate RNA viruses antagonize antiviral innate immunity (2013) (3)
The Use of Triisopropylsilyl-oxymethyl (TOM) in the Synthesis of Anti-telomerase 2-5A Antisense Compound RBI 011 (2003) (3)
IFNL4 - D G Allele Is Associated with an Interferon Signature in Tumors and Survival of African-American Men with Prostate Cancer (2018) (2)
THE 2-5A (pppA2′p5′A2′p5′A) SYSTEM IN INTERFERON-TREATED AND CONTROL CELLS (1981) (2)
2-5A(pppA2'p5'A2'p5'A) in interferon-treated encephalomyocarditis virus-infected mouse L-cells. (1981) (2)
Inhibition of Respiratory Syncytial Virus by Double Termini-Protected 2–5A Antisense Chimeras (1997) (2)
679 CHARACTERIZATION OF XMRV IN PROSTATE CANCER (2010) (2)
Abstract B051: IFNL4-deltaG allele is associated with an interferon signature in tumors and survival of African-American men with prostate cancer (2020) (2)
Oscillation theory of optimal processes (1984) (1)
Polyclonal antibody directed against 2-5A-dependent RNase. (1985) (1)
Syndrome Blood Cells of Patients with Chronic Fatigue Detection of an Infectious Retrovirus , XMRV (2010) (1)
Progress in interferon and cytokine biology. (1998) (1)
Effects of Interferon and Virus Infection (1982) (1)
THE 2-5A SYSTEM AND INTERFERON ACTION (1982) (1)
GUANOSINE 3′, 5′-BIS (DIPHOSPHATE) SEARCH IN EUKARYOTES (1979) (1)
This information is current as during Coxsackievirus Infection Complementary Roles in Islet Cell Defense RNA-Dependent Protein Kinase Exert RNase L and Double-Stranded Williams (2005) (1)
Targeting HIV mRNA for degradation: 2,5-A antisense chimeras as potential chemotherapeutic agents for AIDS (1997) (1)
PS2-69 RNase L produces small RNA activators of innate immunity signaling in sendai virus infected cells (2010) (1)
Regulation of 2-5A-Dependent RNase Levels during Interferon-Treatment, Growth Inhibition and Cell Differentiation (1984) (1)
Specificity and Mechanism of Coronavirus, Rotavirus, and Mammalian Two-Histidine Phosphoesterases That Antagonize Antiviral Innate Immunity (2021) (1)
Targeting RNA for degradation with a (2',5')-oligoadenylate antisense chimera (1995) (1)
Structure-activity relationship of analogs of 2-5A determined using the core-cellulose assay for 2-5A-dependent RNase. (1985) (1)
Pathway by a Murine Coronavirus RNase L - Oligoadenylate Synthetase Cell-Type-Specific Activation of the (2014) (0)
Role of small RNAS generated by RNASE L in signaling innate immunity against hepatitis C virus (2009) (0)
The host antiviral ribonuclease L protein supports Zika virus replication factory formation to enhance infectious virus production (2019) (0)
CS2-3 Viral-host interactions during XMRV infections (2010) (0)
The protein kinase R modifies gut physiology to limit colitis (2023) (0)
SS6-2 Inhibition of RNAse L and PKR by the anti-cancer drug sunitinib impairs innate immunity in virus-infected mice (2010) (0)
O030 Evasion of the OAS-RNase L pathway by murine coronavirus ns2 protein is required for viral replication and hepatitis (2012) (0)
Ablation of SigH+ pDCs in B6.Nba2 mice prevents lupus-like disease development only if started before disease is fully established (2022) (0)
Studies on the role of guanosine 5'-diphosphate 3'- diphosphate and its modulation by 5a,6-anhydrotetracycline (1977) (0)
Efflux + and K MAVS-Induced Membrane Permeabilization the NLRP3 Inflammasome via Cytosolic Double-Stranded RNA Activates (2014) (0)
Abstract 2863: RNase-L modulates the immune response to intestinal damage and ameliorates murine colitis and colitis-associated cancer. (2013) (0)
SY-11 Role of small RNAs generated by RNase L in antiviral innate immunity (2008) (0)
A method for specific cutting of RNA strands (1993) (0)
189 Protein kinase R-dependent regulation of c-JUN and EGR-1 in response to double-stranded RNA (2008) (0)
The wild type RNase L but not mutant laboratory and natural variants suppresses the RNA binding protein, HUR: Effects on cytokine 3′ UTR (2009) (0)
Expressing Murine IFN-VectorVivo Antiviral Effect of an Adenoviral RNA-Dependent Protein Kinase R in the In Synthetases and Double-Stranded-Oligoadenylate ′ , 5 ′ Distinctive Roles for 2 (2004) (0)
274 Identification of small RNAs produced by cleavage of hepatitis C viral RNA with RNase L that bind RIG-I (2008) (0)
2 8 , 5 8-Oligoadenylate-Antisense Chimeras Cause RNase L to Selectively Degrade bcr / abl mRNA in Chronic Myelogenous Leukemia Cells (1998) (0)
P045 A role for Protein Kinase R in regulating NLRP3 inflammasome signaling pathway (2012) (0)
251 Roles of IFN and RNase L in the inhibition of the human retrovirus, XMRV (2008) (0)
280 XMRV INFECTION INDUCES HOST GENES THAT REGULATE INFLAMMATION AND CELLULAR PHYSIOLOGY (2011) (0)
620 RNase L is a regeneration repressor gene (2021) (0)
290: The protein kinase R as a repressor of inflammasome activity (2013) (0)
Synthesis and characterization of RBI-1033, a potent inhibitor of prostate specific membrane antigen that activates RNase L (2005) (0)
205: A role for protein kinase R in regulating NLRP3 inflammasome assembly (2014) (0)
HPC1 (RNaseL), Inflammation, and the Role of Antioxidants in the Chemoprevention of Prostate Cancer (2005) (0)
Expression of Mammalian Antiviral Enzymes from the 2–5A System in Transgenic Plants (1996) (0)
28,58-Oligoadenylate-Antisense Chimeras Cause RNase L to Selectively Degrade bcr/abl mRNA in Chronic Myelogenous Leukemia Cells (1998) (0)
2-5A-Antisense: A Novel Approach to Cancer Therapy (1995) (0)
Chapter 52 – Interferons (2008) (0)
The biology of HCP1/RNasel in prostate cancer: Implications for screening and therapy (2003) (0)
The Viral Defense Gene RNaseL Acts as a Regeneration Repressor (2020) (0)
272: Biological Characterization of XMRV, a Novel Retrovirus Isolated from Human Prostate Tissue (2007) (0)
Improved Metallographic Technique for Observing Reactions of Thin Metal Films on Silicon (1967) (0)
XMRV replicates preferentially in mucosal sites in vivo: Relevance to XMRV transmission? (2011) (0)
794 RNase L is a regeneration repressor gene (2020) (0)
Short Communication RNase L activity does not contribute to host RNA degradation induced by herpes simplex virus infection (2003) (0)
17 PKR-dependent Regulation of IL-10 in Response to Double-stranded RNA (2007) (0)
Author response: Ribonuclease L mediates the cell-lethal phenotype of double-stranded RNA editing enzyme ADAR1 deficiency in a human cell line (2017) (0)
Induced Inflammation and Remodeling -Pattern/Influenza Virus and Cigarette Smoke Pathogen-Associated Molecular Role of Ribonuclease L in Viral (2013) (0)
CS08-7. Role for RNase L in the Induction of IFN-β by Influenza A Virus Lacking NS1 (2011) (0)
Human infection or lab artifact: will the real XMRV please stand up? (2011) (0)
PS2-55 RNase L activation induces autophagy during the host antiviral response (2010) (0)
167: Host and viral 2′,5′-phosphodiesterases antagonize DsRNA signaling to RNase L during antiviral innate immunity (2014) (0)
Correction for Li et al., Activation of RNase L is dependent on OAS3 expression during infection with diverse human viruses (2019) (0)
PS3-09 An RNase L mediated cleavage product of hepatitis C virus RNA requires a 3′- (2010) (0)
Characterization of interferon-regulated pathways using oligonucleotide microarrays (1999) (0)
1450 Regulation of skin regeneration by non-coding RNA sensing (2018) (0)
Role Of Rnasel In Virus/Viral PAMP And Cigarette Smoke-Induced Inflammation And Remodeling (2011) (0)
Ribonucleases of Medical Importance (2002) (0)
Effects of phospholipid scramblase 1 (PLSCR1) on migration and invasion of ovarian cancer cells (2006) (0)
959 Regulation of IL36-mediated skin regeneration by non-coding RNA sensing (2019) (0)

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