Robert A. Holton
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American academic
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Chemistry
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(Suggest an Edit or Addition)According to Wikipedia, Robert A. Holton is an American academic chemist who is known for his work regarding the chemical synthesis for Taxol , a widely utilized and highly effective anti-cancer drug. He is a Professor of Chemistry at Florida State University.
Robert A. Holton's Published Works
Published Works
- First total synthesis of taxol. 1. Functionalization of the B ring (1994) (502)
- First total synthesis of taxol. 2. Completion of the C and D rings (1994) (411)
- Taxol®: science and applications. (1995) (361)
- Screening of a library of phage-displayed peptides identifies human bcl-2 as a taxol-binding protein. (1999) (220)
- A convergent total synthesis of hemibrevetoxin B. (2003) (98)
- A synthesis of taxusin (1988) (93)
- Regiospecific preparation of thermodynamic silyl enol ethers using bromomagnesium dialkylamides (1983) (61)
- Intramolecular oxidative coupling of diphenolic, monophenolic, and nonphenolic substrates (1977) (55)
- Synthesis of the taxane ring system (1984) (46)
- Enantioselective total synthesis of aphidicolin (1987) (44)
- Intramolecular oxidative phenol coupling. II. Biogenetic-type synthesis of (+-)-maritidine (1970) (43)
- Palladium-mediated biomimetic synthesis of narwedine (1988) (40)
- Selective protection of the C(7) and C(10) hydroxyl groups in 10-deacetyl baccatin III (1998) (38)
- Intramolecular oxidative phenol coupling. A new method (1969) (37)
- Semisynthesis of Taxol and Taxotere (1995) (34)
- Carbopalladation-depalladation of allylic amines and sulfides (1977) (33)
- A novel asymmetric synthesis of cis-3-hydroxy-4-aryl azetidin-2-ones (1993) (31)
- Mild method for the reductive desulfurization of .alpha.-phenylthio and .alpha.-phenylsulfinyl carbonyl compounds (1987) (28)
- Stereochemical requirements for fragmentation of homoallylic epoxy alcohols (1985) (26)
- A new regiospecific synthesis of aryl ketones from palladocycles (1981) (26)
- A simple synthesis of 10-deacetoxytaxol derivatives (1994) (26)
- The Kharasch reagent. Regioselective generation of dienyl ethers from enones (1984) (26)
- Direct one step mono-functionalisation of symmetrical 1,2-diols (2000) (26)
- Formation of quaternary centers via the Michael reaction; electronic compensation for steric congestion (1986) (23)
- Prostaglandin synthesis via carbopalladation (1977) (22)
- Intramolecular carbopalladation of allylic amines and sulfides (1985) (21)
- Addition of enones to aryl palladium complexes (1977) (19)
- A novel lanthanide-induced rearrangement (1988) (19)
- REGIOCONTROLLED AROMATIC PALLADATION (1977) (19)
- Biogenetic-type total synthesis. dl-Tetrahymanol (1972) (18)
- Protection of phenols as methylthiomethyl ethers (1977) (16)
- A new stereospecific annulation (1986) (16)
- Preparation of a new, highly reactive form of iron(0) and its use in deprotonation of carbonyl compounds (1984) (16)
- An efficient synthesis of chiral 2-(p-tolylsulfinyl)-2-butenolides (1986) (14)
- Carbopalladation-depalladation of homoallylic amines and sulfides (1977) (14)
- First Total Synthesis of Taxol. Part 1. Functionalization of the B Ring. (1994) (12)
- A New Protecting Group for Phenols: Phenylthiomethyl (PTM) Ethers (1981) (10)
- Orthopalladation of chelating aromatic compounds (1980) (10)
- The rapid separation and isolation of mono- and oligonucleotides by high speed liquid chromatography: an ion exchange, reversed-phase system. (1974) (8)
- Enhanced apoptotic effects of novel paclitaxel analogs on NCI/ADR-RES breast cancer cells. (2003) (8)
- Ketovinylation of Alkyl Palladium Complexes (1977) (8)
- In vitro efficacy of a novel chemoradiopotentiator--taxoltere metro. (2000) (7)
- PREPARATION OF A NEW, HIGHLY REACTIVE FORM OF IRON(0), AND ITS USE IN DEPROTONATION OF CARBONYL COMPOUNDS (1985) (5)
- Selective Protection of the C7 and C10 Hydroxyl Groups in 10-Deacetyl Baccatin III (1998) (4)
- First Total Synthesis of Taxol. Part 2. Completion of the C and D Rings. (1994) (4)
- Using transputers in a robot programming and control system (1992) (3)
- Stereocontrol of the metal-ammonia reduction: formation of either cis- or trans-fused decalones from a common intermediate (1987) (3)
- Novel beta-lactam (1994) (2)
- chemical synthesis of taxol and taxol derivatives. (1994) (0)
- Process for the preparation of novel taxane derivatives of therapeutically useful (1992) (0)
- Derives de substitution alcoxyles de taxanes; compositions pharmaceutiques a base de ces derives (1992) (0)
- A Mild Method for the Reductive Desulfurization of α‐Phenylthio and α‐Phenylsulfinyl Carbonyl Compounds. (1987) (0)
- Nya alkoxisubstituerade taxaner Science innehaollande The compositions of pharmaceutical industry. (1992) (0)
- C10 carbamoyloxysubstituierte taxane as anti-tumor agent (2001) (0)
- TL-1836, a new orally active taxane with curative antitumor activity against human tumor xenografts (2008) (0)
- Taxanes substituted with alkyl side chain and containing the same pharmaceutical compositions (1993) (0)
- Taxanes with furyl or thienylsubstitueret side chain (1994) (0)
- Towards a New Pathway for Synthesis of Taxol and its Analogs (2012) (0)
- A Novel Lanthanide-Induced Rearrangement. (1989) (0)
- Procedure selective derivatization of taxanes. (1998) (0)
- A process for the preparation of 10-desacetoxy baccatin III and 10-desacetoxy taxol and derivatives thereof (1994) (0)
- Taxol synthesis and its derivatives (1994) (0)
- BIOGENESE-AEHNLICHE TOTALSYNTH. D,L-TETRAHYMANOL (1973) (0)
- Beta-lactams the preparation of taxanes with furyl or thienyl substituted side chain (1994) (0)
- Process for the preparation of 9-desoxotaxanos. (1994) (0)
- New alkoxy substituted taxane and medicine composition containing the same (1992) (0)
- Chapter 5 - Total Synthesis of Taxusin: An Initial Step Toward Taxol Synthesis (1991) (0)
- A process for the synthesis of taxanes (1998) (0)
- The method for producing taxol using an oxazinone (1990) (0)
- Process for the preparation of taxol and intermediate products used in the process eet (1990) (0)
- Taxanes having furyl or side chain thienylsubstituerede (1994) (0)
- Compositions containing taxanes C7 (1994) (0)
- Nya furyl- Science tienylsubstituerade taxaner Science innehaollande The compositions of pharmaceutical industry. (1992) (0)
- Furyl or thienylcarbonyl-substituted taxane and pharmaceutical compositions containing them (1993) (0)
- An Efficient Synthesis of Chiral 2-(p-Tolylsulfinyl)-2-butenolides. (1986) (0)
- Enantioselective Total Synthesis of Aphidicolin. (1987) (0)
- Taxanes having the side chain substituted by furyl or thienyl. (1994) (0)
- Formation of Quaternary Centers via the Michael Reaction. Electronic Compensation for Steric Congestion. (1987) (0)
- Nya alkoxisubstituerade taxaner och innehaollande The compositions of pharmaceutical industry (1992) (0)
- A process for the preparation of taxol (1990) (0)
- Texan that does not have an oxo group at C-9, and to pharmaceutical compositions containing these (1994) (0)
- Nya and substituted taxaner Science innehaollande The compositions of pharmaceutical industry. (1992) (0)
- pharmaceutical compositions containing a taxane having a side chain substituted with furyl or thienyl. (1994) (0)
- Beta-lactams which may be used for the preparation of taxanes with a furyl side chain or thienylsubstitueret (1994) (0)
- Taxanes having furyl or thienyl substituted side chain substituted. (1994) (0)
- Taxanes having a substituted alkyl side chain and pharmaceutical compositions containing them. (1993) (0)
- A process for the produ ung of baccatin III analogs, compounds with novel functional groups at C2 and C4 (1994) (0)
- Furyl and thienylsubstituerede taxanes as antitumor agents (1992) (0)
- Preclinical evaluation of TL-1892, a novel orally active taxane with superior in vitro and in vivo efficacy in paclitaxel and docetaxel resistant models (2008) (0)
- A New Stereospecific Annulation. (1986) (0)
- Texan with a side chain alkyl-substituted and pharmaceutical compositions containing them (1993) (0)
- Process for the preparation of therapeutically useful taxane derivatives (1992) (0)
- Isobytenyl-substituted taxanes and pharmaceutical compositions thereof (1993) (0)
- Direct One-Step Mono-Functionalization of Symmetrical 1,2-Diols. (2000) (0)
- Pharmaceutical compositions containing a taxane with a furyl side chain or thienylsubstitueret (1994) (0)
- taxane derivatives C9 and compositions containing them, pharmaceutical (1994) (0)
- Taxanes have an oxo group at c9 and pharmaceutical compositions containing them. (1994) (0)
- Novel substituted taxane and pharmaceutical composition containing the same (1992) (0)
- Beta-lactanas useful in the preparation of taxanes having a side chain furyl or substituted thienyl. (1994) (0)
- Procedure for the synthesis of taxanes. (1998) (0)
- Nya furyl- Science tienylsubstituerade Science taxaner The compositions of pharmaceutical industry innehaollande (1992) (0)
- C7-texanderivater and pharmaceutical compositions containing these (1994) (0)
- A process for the preparation of 9-Desoxotaxanen (1994) (0)
- Stereocontrol of the Metal-Ammonia Reduction: Formation of Either cis- or trans-Fused Decalones from a Common Intermediate. (1987) (0)
- Process for the preparation of a medicament useful in the 3'-alkoxycarbonylamino-substituted taxane derivatives (1992) (0)
- Beta-lactams for the production of taxanes with furyl or thienyl substituted side chain (1994) (0)
- A Synthesis of Taxusin. (1989) (0)
- Taxane with furyl or thienyl substituted carbonyl and pharmaceutical compositions containing them. (1993) (0)
- Taxanes without the C-9 oxo group and pharmaceutical compositions containing them (1994) (0)
- Taxanes containing with furyl or thienyl substituted side chain (1994) (0)
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