Robert L. Last
#68,196
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Biologist and chemist
Robert L. Last's AcademicInfluence.com Rankings
Robert L. Lastchemistry Degrees
Chemistry
#4020
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#5076
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Organic Chemistry
#901
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#1012
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Robert L. Lastbiology Degrees
Biology
#5426
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#7903
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Molecular Biology
#2150
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#2183
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Chemistry Biology
Robert L. Last's Degrees
- PhD Biology University of California, Berkeley
- Masters Chemistry Stanford University
- Bachelors Chemistry Stanford University
Why Is Robert L. Last Influential?
(Suggest an Edit or Addition)According to Wikipedia, Robert L. Last is a plant biochemical genomicist who studies metabolic processes that protect plants from the environment and produce products important for animal and human nutrition. His research has covered production and breakdown of essential amino acids, the synthesis and protective roles of Vitamin C and Vitamin E as well as identification of mechanisms that protect photosystem II from damage, and synthesis and biological functions of plant protective specialized metabolites . Four central questions are: how are leaf and seed amino acids levels regulated, what mechanisms protect and repair photosystem II from stress-induced damage, how do plants produce protective metabolites in their glandular secreting trichomes and what are the evolutionary mechanisms that contribute to the tremendous diversity of specialized metabolites that protect plants from insects and pathogens and are used as therapeutic agents.
Robert L. Last's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Arabidopsis Flavonoid Mutants Are Hypersensitive to UV-B Irradiation. (1993) (997)
- Arabidopsis Map-Based Cloning in the Post-Genome Era (2002) (707)
- Arabidopsis Mutants Lacking Phenolic Sunscreens Exhibit Enhanced Ultraviolet-B Injury and Oxidative Damage (1995) (625)
- Superoxide dismutase in Arabidopsis: an eclectic enzyme family with disparate regulation and protein localization. (1998) (583)
- Environmental stress sensitivity of an ascorbic acid-deficient Arabidopsis mutant. (1996) (525)
- Genetic evidence for the role of GDP-mannose in plant ascorbic acid (vitamin C) biosynthesis. (1999) (384)
- Monoterpenes in the glandular trichomes of tomato are synthesized from a neryl diphosphate precursor rather than geranyl diphosphate (2009) (371)
- Tryptophan biosynthesis and metabolism: biochemical and molecular genetics. (1995) (370)
- Harnessing plant trichome biochemistry for the production of useful compounds. (2008) (339)
- Arabidopsis UVR8 Regulates Ultraviolet-B Signal Transduction and Tolerance and Contains Sequence Similarity to Human Regulator of Chromatin Condensation 1 (2002) (331)
- Identification of ascorbic acid-deficient Arabidopsis thaliana mutants. (2000) (297)
- The Tomato Terpene Synthase Gene Family1[W][OA] (2011) (269)
- Arabidopsis cyt1 mutants are deficient in a mannose-1-phosphate guanylyltransferase and point to a requirement of N-linked glycosylation for cellulose biosynthesis (2001) (262)
- Engineering Vitamin E Content: From Arabidopsis Mutant to Soy Oil Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.015875. (2003) (242)
- L-Ascorbic Acid Metabolism in the Ascorbate-Deficient Arabidopsis Mutant vtc1 (1997) (215)
- Differential Accumulation of Antioxidant mRNAs in Arabidopsis thaliana Exposed to Ozone (1995) (202)
- An Arabidopsis photolyase mutant is hypersensitive to ultraviolet-B radiation. (1997) (182)
- The Arabidopsis vitamin E pathway gene5-1 Mutant Reveals a Critical Role for Phytol Kinase in Seed Tocopherol Biosynthesis[W][OA] (2005) (180)
- Mass spectrometry screening reveals widespread diversity in trichome specialized metabolites of tomato chromosomal substitution lines (2010) (178)
- Ethylmethanesulfonate Saturation Mutagenesis in Arabidopsis to Determine Frequency of Herbicide Resistance (2003) (176)
- LSD1 regulates salicylic acid induction of copper zinc superoxide dismutase in Arabidopsis thaliana. (1999) (176)
- Induction of Arabidopsis Tryptophan Pathway Enzymes and Camalexin by Amino Acid Starvation, Oxidative Stress, and an Abiotic Elicitor (1998) (175)
- Tryptophan-Requiring Mutants of the Plant Arabidopsis thaliana (1988) (169)
- Tryptophan mutants in Arabidopsis: the consequences of duplicated tryptophan synthase beta genes. (1991) (168)
- UV-B-induced photomorphogenesis in Arabidopsis thaliana. (1998) (154)
- The Arabidopsis thaliana trp5 Mutant Has a Feedback-Resistant Anthranilate Synthase and Elevated Soluble Tryptophan (1996) (146)
- Predictive Metabolic Engineering: A Goal for Systems Biology1 (2003) (145)
- Coordinate regulation of the tryptophan biosynthetic pathway and indolic phytoalexin accumulation in Arabidopsis. (1996) (142)
- Arabidopsis ESK1 encodes a novel regulator of freezing tolerance. (2007) (140)
- An enzyme similar to animal type II photolyases mediates photoreactivation in Arabidopsis. (1997) (137)
- Identification of a BAHD acetyltransferase that produces protective acyl sugars in tomato trichomes (2012) (136)
- Innovations: Towards the plant metabolome and beyond (2007) (132)
- Studies of a Biochemical Factory: Tomato Trichome Deep Expressed Sequence Tag Sequencing and Proteomics1[W][OA] (2010) (132)
- Introns act post-transcriptionally to increase expression of the Arabidopsis thaliana tryptophan pathway gene PAT1. (1997) (128)
- Suppressors of trp1 fluorescence identify a new arabidopsis gene, TRP4, encoding the anthranilate synthase beta subunit. (1993) (118)
- Application of a high-throughput HPLC-MS/MS assay to Arabidopsis mutant screening; evidence that threonine aldolase plays a role in seed nutritional quality. (2004) (115)
- Minimum reporting standards for plant biology context information in metabolomic studies (2007) (111)
- A Small Zinc Finger Thylakoid Protein Plays a Role in Maintenance of Photosystem II in Arabidopsis thaliana[W][OA] (2011) (106)
- Large-Scale Reverse Genetics in Arabidopsis: Case Studies from the Chloroplast 2010 Project1[C][W][OA] (2009) (101)
- Evolution of TPS20-related terpene synthases influences chemical diversity in the glandular trichomes of the wild tomato relative Solanum habrochaites (2012) (93)
- Functionally Divergent Alleles and Duplicated Loci Encoding an Acyltransferase Contribute to Acylsugar Metabolite Diversity in Solanum Trichomes[OPEN] (2015) (93)
- Characterization of seed-specific benzoyloxyglucosinolate mutations in Arabidopsis thaliana. (2007) (89)
- New Connections across Pathways and Cellular Processes: Industrialized Mutant Screening Reveals Novel Associations between Diverse Phenotypes in Arabidopsis1[W][OA] (2008) (89)
- Broad connections in the Arabidopsis seed metabolic network revealed by metabolite profiling of an amino acid catabolism mutant. (2010) (89)
- FATTY ACID DESATURASE4 of Arabidopsis encodes a protein distinct from characterized fatty acid desaturases. (2009) (88)
- In vitro reconstruction and analysis of evolutionary variation of the tomato acylsucrose metabolic network (2015) (86)
- Striking Natural Diversity in Glandular Trichome Acylsugar Composition Is Shaped by Variation at the Acyltransferase2 Locus in the Wild Tomato Solanum habrochaites1[W][OA] (2012) (79)
- LC-MS/MS assay for protein amino acids and metabolically related compounds for large-scale screening of metabolic phenotypes. (2007) (77)
- A Phosphoribosylanthranilate Transferase Gene Is Defective in Blue Fluorescent Arabidopsis thaliana Tryptophan Mutants. (1992) (75)
- Immunological Characterization and Chloroplast Localization of the Tryptophan Biosynthetic Enzymes of the Flowering Plant Arabidopsis thaliana(*) (1995) (73)
- A gene encoding the tryptophan synthase beta subunit of Arabidopsis thaliana. (1989) (72)
- Evolutionary routes to biochemical innovation revealed by integrative analysis of a plant-defense related specialized metabolic pathway (2017) (71)
- A Feedback-Insensitive Isopropylmalate Synthase Affects Acylsugar Composition in Cultivated and Wild Tomato1[OPEN] (2015) (69)
- Chloroplast 2010: A Database for Large-Scale Phenotypic Screening of Arabidopsis Mutants1[W][OA] (2011) (69)
- Something Old, Something New: Conserved Enzymes and the Evolution of Novelty in Plant Specialized Metabolism (2015) (68)
- The Impact of the Branched-Chain Ketoacid Dehydrogenase Complex on Amino Acid Homeostasis in Arabidopsis1[OPEN] (2015) (68)
- Something Old, Something New: Conserved Enzymes and the Evolution of Novelty in Plant Specialized Metabolism1 (2015) (65)
- Achieving Diversity in the Face of Constraints: Lessons from Metabolism (2012) (64)
- Reduced activity of Arabidopsis thaliana HMT2, a methionine biosynthetic enzyme, increases seed methionine content. (2008) (63)
- Robust predictions of specialized metabolism genes through machine learning (2018) (62)
- Characterization of the Arabidopsis TU8 Glucosinolate Mutation,an Allele of TERMINAL FLOWER2 (2004) (56)
- Taming the hydra of specialized metabolism: how systems biology and comparative approaches are revolutionizing plant biochemistry. (2012) (55)
- Characterization of tryptophan synthase alpha subunit mutants of Arabidopsis thaliana (1996) (55)
- Evolution of metabolic novelty: A trichome-expressed invertase creates specialized metabolic diversity in wild tomato (2018) (52)
- A New Light on Photosystem II Maintenance in Oxygenic Photosynthesis (2019) (50)
- Arabidopsis phosphoribosylanthranilate isomerase: molecular genetic analysis of triplicate tryptophan pathway genes. (1995) (50)
- Tip of the trichome: evolution of acylsugar metabolic diversity in Solanaceae. (2019) (49)
- Evidence for related functions of the RNA genes of Saccharomyces cerevisiae. (1987) (49)
- Analysis of Natural and Induced Variation in Tomato Glandular Trichome Flavonoids Identifies a Gene Not Present in the Reference Genome[W][OPEN] (2014) (48)
- Utility and Limitations of Using Gene Expression Data to Identify Functional Associations (2016) (47)
- Shotguns and SNPs: how fast and cheap sequencing is revolutionizing plant biology. (2010) (46)
- Homeostasis of branched-chain amino acids is critical for the activity of TOR signaling in Arabidopsis (2019) (44)
- Analysis of Essential Arabidopsis Nuclear Genes Encoding Plastid-Targeted Proteins (2013) (43)
- Evolution of a flipped pathway creates metabolic innovation in tomato trichomes through BAHD enzyme promiscuity (2017) (42)
- PHOTOSYSTEM II PROTEIN33, a Protein Conserved in the Plastid Lineage, Is Associated with the Chloroplast Thylakoid Membrane and Provides Stability to Photosystem II Supercomplexes in Arabidopsis1[OPEN] (2014) (38)
- Promiscuity, impersonation and accommodation: evolution of plant specialized metabolism. (2017) (37)
- Coexpression Analysis Identifies Two Oxidoreductases Involved in the Biosynthesis of the Monoterpene Acid Moiety of Natural Pyrethrin Insecticides in Tanacetum cinerariifolium1[OPEN] (2017) (36)
- A Regulatory Hierarchy of the Arabidopsis Branched-Chain Amino Acid Metabolic Network[OPEN] (2017) (35)
- Arabidopsis thaliana tryptophan synthase alpha: Gene cloning, expression, and subunit interaction (1995) (35)
- ups1, an Arabidopsis thaliana camalexin accumulation mutant defective in multiple defence signalling pathways. (2005) (34)
- Acylsugar Acylhydrolases: Carboxylesterase-Catalyzed Hydrolysis of Acylsugars in Tomato Trichomes1[OPEN] (2016) (34)
- A chloroplast thylakoid lumen protein is required for proper photosynthetic acclimation of plants under fluctuating light environments (2017) (34)
- Evolution of a plant gene cluster in Solanaceae and emergence of metabolic diversity (2020) (32)
- 5-Fluoroindole resistance identifies tryptophan synthase beta subunit mutants in Arabidopsis thaliana. (1995) (32)
- Expression Patterns of Duplicate Tryptophan Synthase [beta] Genes in Arabidopsis thaliana (1993) (30)
- Isolation of cDNAs Encoding the Tryptophan Pathway Enzyme Indole-3-Glycerol Phosphate Synthase from Arabidopsis thaliana (1995) (28)
- Genome-Enabled Approaches Shed New Light on Plant Metabolism (2008) (27)
- Isolation and characterization of the RNA2, RNA3, and RNA11 genes of Saccharomyces cerevisiae (1984) (26)
- Identification and nuclear localization of yeast pre-messenger RNA processing components: RNA2 and RNA3 proteins (1986) (26)
- Introgression of acylsugar chemistry QTL modifies the composition and structure of acylsugars produced by high-accumulating tomato lines (2016) (26)
- How Plants Synthesize Pyrethrins: Safe and Biodegradable Insecticides. (2020) (25)
- A land plant-specific thylakoid membrane protein contributes to photosystem II maintenance in Arabidopsis thaliana. (2015) (24)
- A J-Like Protein Influences Fatty Acid Composition of Chloroplast Lipids in Arabidopsis (2011) (23)
- Location, location! cellular relocalization primes specialized metabolic diversification (2020) (21)
- Quantitative trait loci analysis (QTL) of seed specialized metabolites reveals seed-specific flavonols and differential regulation of glycoalkaloid content in tomato. (2020) (20)
- Production of trans-chrysanthemic acid, the monoterpene acid moiety of natural pyrethrin insecticides, in tomato fruit. (2018) (20)
- An allelic series of blue fluorescent trp1 mutants of Arabidopsis thaliana. (1997) (19)
- Twenty-First Century Plant Biology: Impacts of the Arabidopsis Genome on Plant Biology and Agriculture (2010) (19)
- MIPHENO: data normalization for high throughput metabolite analysis (2012) (18)
- The genetics of nitrogen assimilation and amino acid biosynthesis in flowering plants: progress and prospects. (1993) (17)
- Rapid LC-MS/MS profiling of protein amino acids and metabolically related compounds for large-scale assessment of metabolic phenotypes. (2012) (16)
- Web-Based Arabidopsis Functional and Structural Genomics Resources (2008) (15)
- Specialized Metabolism in a Nonmodel Nightshade: Trichome Acylinositol Biosynthesis1[OPEN] (2020) (13)
- Migration through a Major Andean Ecogeographic Disruption as a Driver of Genetic and Phenotypic Diversity in a Wild Tomato Species (2021) (13)
- MPH1 is a thylakoid membrane protein involved in protecting photosystem II from photodamage in land plants (2015) (13)
- Diverse regulatory mechanisms of amino acid biosynthesis in plants. (1999) (12)
- It happened again: Convergent evolution of acylglucose specialized metabolism in black nightshade and wild tomato (2021) (12)
- Pyrethrin Biosynthesis: The Cytochrome P450 Oxidoreductase CYP82Q3 Converts Jasmolone To Pyrethrolone1[OPEN] (2019) (12)
- The Impact of the Branched-Chain Ketoacid Dehydrogenase Complex on Amino 13 Acid Homeostasis in Arabidopsis (2015) (11)
- An Integrated Analytical Approach Reveals Trichome Acylsugar Metabolite Diversity in the Wild Tomato Solanum pennellii (2020) (9)
- Chloroplast phenomics: systematic phenotypic screening of chloroplast protein mutants in Arabidopsis. (2011) (9)
- Comparative Biochemistry and In Vitro Pathway Reconstruction as Powerful Partners in Studies of Metabolic Diversity. (2016) (8)
- A Trichome-Specific, Plastid-Localized Tanacetum cinerariifolium Nudix Protein Hydrolyzes the Natural Pyrethrin Pesticide Biosynthetic Intermediate trans-Chrysanthemyl Diphosphate (2020) (8)
- Within- and cross-species predictions of plant specialized metabolism genes using transfer learning (2020) (8)
- Degradation of salicylic acid to catechol in Solanaceae by SA 1-hydroxylase. (2021) (7)
- Current status of the multinational Arabidopsis community (2020) (7)
- Switchgrass Metabolomics Reveals Striking Genotypic and Developmental Differences in Specialized Metabolic Phenotypes (2020) (6)
- PHOTOSYSTEM II PROTEIN 33 , a Protein Conserved in the Plastid Lineage , Is Associated with the Chloroplast Thylakoid Membrane and Provides Stability to Photosystem II Supercomplexes in Arabidopsis 1 [ OPEN ] (2015) (5)
- The Wide World of Plant Molecular Genetics (1993) (5)
- Pyrethrin Biosynthesis: The Cytochrome P450 Oxidoreductase CYP82Q3 Converts Jasmolone To Pyrethrolone1 [OPEN]. (2019) (4)
- Deep roots and many branches: Origins of plant-specialized metabolic enzymes in general metabolism. (2022) (4)
- Comparative transcriptomics and metabolomics reveal specialized metabolite drought stress responses in switchgrass (Panicum virgatum) (2022) (3)
- Author response: Homeostasis of branched-chain amino acids is critical for the activity of TOR signaling in Arabidopsis (2019) (2)
- The tomato ( Solanum lycopersicum ) terpene synthase gene family 1 (2011) (2)
- Sandbox Ethics in Science: Sharing of Data and Materials in Plant Biology (2003) (2)
- Fruity, sticky, stinky, spicy, bitter, addictive, and deadly: evolutionary signatures of metabolic complexity in the Solanaceae. (2022) (2)
- Coexpression Analysis Identi fi es Two Oxidoreductases Involved in the Biosynthesis of the Monoterpene Acid Moiety of Natural Pyrethrin Insecticides in Tanacetum cinerariifolium 1[OPEN] (2017) (2)
- Put on Your Sunscreen: The Birth of Arabidopsis Abiotic Stress Genetics. (2019) (1)
- Update on Metabolic Evolution Something Old , Something New : Conserved Enzymes and the Evolution of Novelty in Plant Specialized Metabolism 1 (2015) (1)
- Natural Variation Meets Synthetic Biology: Promiscuous Trichome-Expressed Acyltransferases from Nicotiana. (2022) (1)
- MIPHENO: data normalization for high throughput metabolite analysis (2012) (1)
- A Crucial Role for the NSF Postdoctoral Fellowship Program in Plant Biology. (1993) (1)
- Perspectives in Systems Biology Predictive Metabolic Engineering : A Goal for Systems Biology 1 (2003) (1)
- Bioinformatics Chloroplast 2010 : A Database for Large-Scale Phenotypic Screening of Arabidopsis Mutants 1 [ W ] [ OA ] (2011) (1)
- Natural Variation Meets Synthetic Biology: Promiscuous Trichome Expressed Acyltransferases from Nicotiana acuminata (2022) (0)
- Identification and Nuclear Localization of Yeast (2002) (0)
- Identification of BAHD acyltransferases associated with acylinositol biosynthesis in Solanum quitoense (naranjilla) (2022) (0)
- Migration through a major Andean ecogeographic disruption as a driver of genotypic and phenotypic diversity in a wild tomato species (2020) (0)
- Weed Power, Translating Arabidopsis (2004) (0)
- The Rising of Acylsugar Diversity: Metabolic Innovation in Tomato Trichomes through BAHD Enzyme Promiscuity and Pathway Evolution (2018) (0)
- Genome Analysis Striking Natural Diversity in Glandular Trichome Acylsugar Composition Is Shaped by Variation at the Acyltransferase 2 Locus in the Wild Tomato Solanum habrochaites 1 [ W ] [ OA ] (2012) (0)
- Solanaceae specialized metabolism in a non-model plant: trichome acylinositol biosynthesis (2020) (0)
- Multi-omic analysis of a hyper-diverse plant metabolic pathway reveals evolutionary routes to biological innovation (2017) (0)
- Put on Your Sunscreen: The Birth of Arabidopsis Abiotic Stress Genetics[OPEN] (2019) (0)
- Evolution of a flipped pathway creates metabolic innovation in tomato trichomes through BAHD enzyme promiscuity (2017) (0)
- Correction: Fruity, sticky, stinky, spicy, bitter, addictive, and deadly: evolutionary signatures of metabolic complexity in the Solanaceae (2022) (0)
- Isolation and Characterization of the RNA2, RNA3, and RNAJJ Genes of Saccharomyces cerevisiae (0)
- Identification of anti-fungal bioactive terpenoids from the bioenergy crop switchgrass (Panicum virgatum) (2023) (0)
- Introgression of acylsugar chemistry QTL modifies the composition and structure of acylsugars produced by high-accumulating tomato lines (2016) (0)
- An Integrated Analytical Approach Reveals Trichome (2020) (0)
- Metabolism Achieving Diversity in the Face of Constraints : Lessons from (2012) (0)
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