Robert Lefkowitz

Q: What Schools Are Affiliated With Robert Lefkowitz

Robert Lefkowitz is affiliated with the following schools: University of Texas at Austin, Weizmann Institute of Science, Hiroshima University, University of Oxford, Icahn School of Medicine at Mount Sinai, University of Chicago, Semmelweis University, University of Glasgow, University of Iowa, Columbia University, Massachusetts General Hospital, Duke University, Yale University, University College London, Vanderbilt University, Stanford University, Rockefeller University, Johns Hopkins University, University of North Carolina at Chapel Hill, University of Utah, Harvard University

Robert Lefkowitz's AcademicInfluence.com Rankings

Robert Lefkowitz

Biology

#170

World Rank

#312

Historical Rank

#103

USA Rank

Biochemistry

#14

World Rank

#17

Historical Rank

#10

USA Rank

biology Degrees

Robert Lefkowitz

Philosophy

#983

World Rank

#1883

Historical Rank

#418

USA Rank

Logic

#127

World Rank

#302

Historical Rank

#56

USA Rank

philosophy Degrees

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Biology
Philosophy

Robert Lefkowitz's Degrees

Doctorate Medicine Columbia University
Bachelors Chemistry Columbia University

Why Is Robert Lefkowitz Influential?

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According to Wikipedia, Robert Joseph Lefkowitz is an American physician and biochemist. He is best known for his groundbreaking discoveries that reveal the inner workings of an important family G protein-coupled receptors, for which he was awarded the 2012 Nobel Prize for Chemistry with Brian Kobilka. He is currently an Investigator with the Howard Hughes Medical Institute as well as a James B. Duke Professor of Medicine and Professor of Biochemistry and Chemistry at Duke University.

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Robert Lefkowitz's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. (1999) (1456)
A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor. (1980) (1448)
Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A (1997) (1319)
Model systems for the study of seven-transmembrane-segment receptors. (1991) (1266)
International Union of Pharmacology nomenclature of adrenoceptors. (1994) (1237)
Turning off the signal: desensitization of β‐adrenergic receptor function (1990) (1233)
β-Arrestins and Cell Signaling (2007) (1175)
A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model. (1993) (1173)
The role of beta-arrestins in the termination and transduction of G-protein-coupled receptor signals. (2002) (1167)
Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin (1986) (1137)
beta-Arrestin: a protein that regulates beta-adrenergic receptor function. (1990) (1127)
Transduction of Receptor Signals by ß-Arrestins (2005) (1126)
Seven-transmembrane-spanning receptors and heart function (2002) (978)
An Akt/β-Arrestin 2/PP2A Signaling Complex Mediates Dopaminergic Neurotransmission and Behavior (2005) (954)
G Protein-coupled Receptors (1998) (935)
Enhanced morphine analgesia in mice lacking beta-arrestin 2. (1999) (929)
Signalling: Seven-transmembrane receptors (2002) (854)
Activation and targeting of extracellular signal-regulated kinases by β-arrestin scaffolds (2001) (848)
Desensitization of G protein-coupled receptors and neuronal functions. (2004) (843)
Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3. (2000) (834)
Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins. (1993) (806)
Teaching old receptors new tricks: biasing seven-transmembrane receptors (2010) (798)
μ-Opioid receptor desensitization by β-arrestin-2 determines morphine tolerance but not dependence (2000) (755)
Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor. (1994) (738)
Regulation of tyrosine kinase cascades by G-protein-coupled receptors. (1999) (737)
International Union of Pharmacology. X. Recommendation for nomenclature of alpha 1-adrenoceptors: consensus update. (1995) (728)
Beta-arrestins and cell signaling. (2007) (722)
Regulation of Receptor Fate by Ubiquitination of Activated β2-Adrenergic Receptor and β-Arrestin (2001) (702)
Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor. (1995) (682)
Molecular mechanisms of receptor desensitization using the β-adrenergic receptor-coupled adenylate cyclase system as a model (1985) (681)
Chimeric alpha 2-,beta 2-adrenergic receptors: delineation of domains involved in effector coupling and ligand binding specificity. (1988) (670)
Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor. (1987) (662)
Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors. (1992) (652)
β-Arrestin-dependent, G Protein-independent ERK1/2 Activation by the β2 Adrenergic Receptor* (2005) (636)
Independent β-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2 (2003) (611)
β-Arrestin-mediated receptor trafficking and signal transduction. (2011) (610)
Regulation of transmembrane signaling by receptor phosphorylation (1987) (589)
Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor. (1986) (581)
GRKs and β-arrestins: roles in receptor silencing, trafficking and signaling (2006) (574)
The genomic clone G-21 which resembles a β-adrenergic receptor sequence encodes the 5-HT1A receptor (1988) (574)
cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor. (1987) (569)
Beta-adrenergic receptors: biochemical mechanisms of physiological regulation. (1984) (567)
Endocytosis of G protein-coupled receptors: roles of G protein-coupled receptor kinases and ß-arrestin proteins (2002) (564)
Molecular mechanism of β-arrestin-biased agonism at seven-transmembrane receptors. (2012) (559)
Essential Role for G Protein-coupled Receptor Endocytosis in the Activation of Mitogen-activated Protein Kinase* (1998) (558)
Thyroid hormone regulation of beta-adrenergic receptor number. (1977) (552)
A family of receptors coupled to guanine nucleotide regulatory proteins. (1987) (551)
Distinct Phosphorylation Sites on the β2-Adrenergic Receptor Establish a Barcode That Encodes Differential Functions of β-Arrestin (2011) (549)
Validation and statistical analysis of a computer modeling method for quantitative analysis of radioligand binding data for mixtures of pharmacological receptor subtypes. (1982) (546)
The β2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange (1998) (544)
β-Arrestin-biased ligands at seven-transmembrane receptors (2007) (540)
Constitutive activation of the alpha 1B-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation. (1992) (537)
Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway (1995) (531)
A quantitative analysis of beta-adrenergic receptor interactions: resolution of high and low affinity states of the receptor by computer modeling of ligand binding data. (1980) (530)
Palmitoylation of the human beta 2-adrenergic receptor. Mutation of Cys341 in the carboxyl tail leads to an uncoupled nonpalmitoylated form of the receptor. (1989) (525)
Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice. (1998) (524)
Role of c-Src Tyrosine Kinase in G Protein-coupled Receptorand Gβγ Subunit-mediated Activation of Mitogen-activated Protein Kinases* (1996) (521)
Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family. (1992) (516)
β-arrestin- but not G protein-mediated signaling by the “decoy” receptor CXCR7 (2009) (515)
Differential Kinetic and Spatial Patterns of β-Arrestin and G Protein-mediated ERK Activation by the Angiotensin II Receptor* (2004) (514)
Specific receptor sites for chemotactic peptides on human polymorphonuclear leukocytes. (1977) (508)
A unique mechanism of β-blocker action: Carvedilol stimulates β-arrestin signaling (2007) (505)
Molecular cloning and expression of the cDNA for the hamster alpha 1-adrenergic receptor. (1988) (500)
Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy. (1998) (491)
Cloning of the cDNA for the human beta 1-adrenergic receptor. (1987) (488)
Cross-talk between cellular signalling pathways suggested by phorbol-ester-induced adenylate cyclase phosphorylation (1987) (485)
Therapeutic potential of β-arrestin- and G protein-biased agonists. (2011) (485)
Ras-dependent Mitogen-activated Protein Kinase Activation by G Protein-coupled Receptors (1997) (479)
Classical and new roles of β-arrestins in the regulation of G-PROTEIN-COUPLED receptors (2001) (477)
Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes. (2001) (475)
An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins (1987) (472)
Activation of the cloned muscarinic potassium channel by G protein βγ subunits (1994) (471)
Functional desensitization of the isolated beta-adrenergic receptor by the beta-adrenergic receptor kinase: potential role of an analog of the retinal protein arrestin (48-kDa protein). (1987) (457)
Regulation of G protein-coupled receptor kinases and arrestins during receptor desensitization. (2003) (456)
Structure and mechanism of the G protein-coupled receptor kinases. (1993) (455)
Mitogenic signaling via G protein-coupled receptors. (1996) (452)
Gbetagamma subunits mediate Src-dependent phosphorylation of the epidermal growth factor receptor. A scaffold for G protein-coupled receptor-mediated Ras activation. (1997) (448)
Multifaceted roles of beta-arrestins in the regulation of seven-membrane-spanning receptor trafficking and signalling. (2003) (441)
Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G beta gamma activation of p21ras. (1994) (441)
Adenylate cyclase-coupled beta-adrenergic receptors: structure and mechanisms of activation and desensitization. (1983) (436)
Molecular Basis for Interactions of G Protein βγ Subunits with Effectors (1998) (436)
Biased signalling: from simple switches to allosteric microprocessors (2018) (433)
The binding site for the beta gamma subunits of heterotrimeric G proteins on the beta-adrenergic receptor kinase. (1993) (431)
Physiological effects of inverse agonists in transgenic mice with myocardial overexpression of the β2-adrenoceptor (1995) (431)
New mechanisms in heptahelical receptor signaling to mitogen activated protein kinase cascades (2001) (430)
A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins. (1998) (428)
Binding of G protein beta gamma-subunits to pleckstrin homology domains. (1994) (428)
Visualization of arrestin recruitment by a G Protein-Coupled Receptor (2014) (421)
Removal of phosphorylation sites from the β2-adrenergic receptor delays onset of agonist-promoted desensitization (1988) (419)
Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes. (1999) (419)
Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence. (2000) (415)
Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates G beta gamma-mediated signaling. (1994) (414)
Historical review: a brief history and personal retrospective of seven-transmembrane receptors. (2004) (408)
Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling. (2011) (406)
Distinct β-Arrestin- and G Protein-dependent Pathways for Parathyroid Hormone Receptor-stimulated ERK1/2 Activation* (2006) (405)
β-Arrestin Scaffolding of the ERK Cascade Enhances Cytosolic ERK Activity but Inhibits ERK-mediated Transcription following Angiotensin AT1a Receptor Stimulation* (2002) (403)
The β2-Adrenergic Receptor Mediates Extracellular Signal-regulated Kinase Activation via Assembly of a Multi-receptor Complex with the Epidermal Growth Factor Receptor* (2000) (402)
beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor. (2006) (398)
Cloning and expression of a human kidney cDNA for an alpha 2-adrenergic receptor subtype. (1988) (397)
Myocardial expression of a constitutively active alpha 1B-adrenergic receptor in transgenic mice induces cardiac hypertrophy. (1994) (397)
Phosphorylation sites on two domains of the beta 2-adrenergic receptor are involved in distinct pathways of receptor desensitization. (1989) (394)
Adrenergic receptors. Models for the study of receptors coupled to guanine nucleotide regulatory proteins. (1988) (392)
GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling (2016) (390)
Functional specialization of β-arrestin interactions revealed by proteomic analysis (2007) (389)
Distribution of α2-adrenergic receptor subtype gene expression in rat brain (1994) (388)
β-Arrestin–mediated β1-adrenergic receptor transactivation of the EGFR confers cardioprotection (2007) (385)
Keeping G Proteins at Bay: A Complex Between G Protein-Coupled Receptor Kinase 2 and Gßγ (2003) (381)
Beta-adrenergic receptor kinase: primary structure delineates a multigene family. (1989) (377)
Phosphatidylinositol 3-Kinase Is an Early Intermediate in the Gβγ-mediated Mitogen-activated Protein Kinase Signaling Pathway (*) (1996) (372)
Molecular cloning and expression of the cDNA for the alpha 1A-adrenergic receptor. The gene for which is located on human chromosome 5. (1991) (371)
The Role of Sequestration in G Protein-coupled Receptor Resensitization (1997) (371)
Molecular cloning and expression of the cDNA for a novel alpha 1-adrenergic receptor subtype. (1990) (371)
Multiple pathways of rapid beta 2-adrenergic receptor desensitization. Delineation with specific inhibitors. (1990) (370)
Distinct Pathways of G- and G-mediated Mitogen-activated Protein Kinase Activation (*) (1995) (370)
Beta-adrenergic receptor sequestration. A potential mechanism of receptor resensitization. (1993) (369)
Structure of active β-arrestin1 bound to a G protein-coupled receptor phosphopeptide (2013) (367)
The Stability of the G Protein-coupled Receptor-β-Arrestin Interaction Determines the Mechanism and Functional Consequence of ERK Activation* (2003) (367)
beta-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking. (2001) (362)
Identification of beta-adrenergic receptors in human lymphocytes by (-) (3H) alprenolol binding. (1976) (360)
A highly conserved tyrosine residue in G protein-coupled receptors is required for agonist-mediated beta 2-adrenergic receptor sequestration. (1994) (354)
Functional antagonism of different G protein-coupled receptor kinases for beta-arrestin-mediated angiotensin II receptor signaling. (2005) (351)
Pleckstrin Homology Domain-mediated Membrane Association and Activation of the -Adrenergic Receptor Kinase Requires Coordinate Interaction with G Subunits and Lipid(*) (1995) (350)
Expanding roles for beta-arrestins as scaffolds and adapters in GPCR signaling and trafficking. (2001) (350)
Dishevelled 2 Recruits ß-Arrestin 2 to Mediate Wnt5A-Stimulated Endocytosis of Frizzled 4 (2003) (348)
Regulation of adenylyl cyclase-coupled beta-adrenergic receptors. (1988) (347)
Targeting of Cyclic AMP Degradation to β2-Adrenergic Receptors by β-Arrestins (2002) (343)
Catecholamine-induced subsensitivity of adenylate cyclase associated with loss of beta-adrenergic receptor binding sites. (1975) (343)
A β-arrestin 2 Signaling Complex Mediates Lithium Action on Behavior (2008) (341)
Heptahelical Receptor Signaling: Beyond the G Protein Paradigm (1999) (340)
G protein—coupled receptor kinases (1993) (339)
Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function. (1996) (339)
Dopaminergic receptors in the anterior pituitary gland. Correlation of [3H]dihydroergocryptine binding with the dopaminergic control of prolactin release. (1978) (338)
GRKs and beta-arrestins: roles in receptor silencing, trafficking and signaling. (2006) (337)
Site-directed mutagenesis of the cytoplasmic domains of the human beta 2-adrenergic receptor. Localization of regions involved in G protein-receptor coupling. (1988) (334)
Quantifying Ligand Bias at Seven-Transmembrane Receptors (2011) (332)
Retraction for Baillie et al., β-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates β-adrenoceptor switching from Gs to Gi (2003) (331)
Receptor-specific desensitization with purified proteins. Kinase dependence and receptor specificity of beta-arrestin and arrestin in the beta 2-adrenergic receptor and rhodopsin systems. (1992) (330)
Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor. (2005) (329)
Phosphorylation and desensitization of the human beta 1-adrenergic receptor. Involvement of G protein-coupled receptor kinases and cAMP-dependent protein kinase. (1995) (326)
Identification, quantification, and localization of mRNA for three distinct alpha 1 adrenergic receptor subtypes in human prostate. (1993) (325)
Beta-arrestin-biased ligands at seven-transmembrane receptors. (2007) (325)
Trafficking of G Protein–Coupled Receptors (2006) (324)
Mechanisms of membrane-receptor regulation. Biochemical, physiological, and clinical insights derived from studies of the adrenergic receptors. (1984) (322)
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1 (2011) (322)
Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2. (2003) (312)
New roles for beta-arrestins in cell signaling: not just for seven-transmembrane receptors. (2006) (307)
G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity. (1991) (303)
beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein. (1998) (297)
Radioligand binding studies of adrenergic receptors: new insights into molecular and physiological regulation. (1980) (297)
Phorbol esters promote alpha 1-adrenergic receptor phosphorylation and receptor uncoupling from inositol phospholipid metabolism. (1985) (293)
Regulation of β-Adrenergic Receptor Signaling by S-Nitrosylation of G-Protein-Coupled Receptor Kinase 2 (2007) (287)
Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by beta-adrenergic receptor stimulation and blockade. (1998) (285)
Role of phosphorylation in desensitization of the β-adrenoceptor (1990) (284)
β-Arrestin–Mediated Localization of Smoothened to the Primary Cilium (2008) (283)
Defective lymphocyte chemotaxis in β-arrestin2- and GRK6-deficient mice (2002) (282)
Activity-Dependent Internalization of Smoothened Mediated by ß-Arrestin 2 and GRK2 (2004) (282)
Isoprenylation in regulation of signal transduction by G-protein-coupled receptor kinases (1992) (282)
Regions of the alpha 1-adrenergic receptor involved in coupling to phosphatidylinositol hydrolysis and enhanced sensitivity of biological function. (1990) (281)
Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2. (1990) (279)
Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands (2009) (278)
Differential Mechanisms of Morphine Antinociceptive Tolerance Revealed in βArrestin-2 Knock-Out Mice (2002) (276)
Src-mediated Tyrosine Phosphorylation of Dynamin Is Required for β2-Adrenergic Receptor Internalization and Mitogen-activated Protein Kinase Signaling* (1999) (275)
Ca-dependent Interaction of Recoverin with Rhodopsin Kinase (*) (1995) (275)
Structure-Function Relationships (1991) (269)
β-arrestins: traffic cops of cell signaling (2004) (269)
Pleiotropic Coupling of G Protein-coupled Receptors to the Mitogen-activated Protein Kinase Cascade (1999) (269)
Phosphorylation of the mammalian beta-adrenergic receptor by cyclic AMP-dependent protein kinase. Regulation of the rate of receptor phosphorylation and dephosphorylation by agonist occupancy and effects on coupling of the receptor to the stimulatory guanine nucleotide regulatory protein. (1985) (264)
Elevated beta-adrenergic receptor number after chronic propranolol treatment. (1977) (259)
Cardiac βARK1 inhibition prolongs survival and augments β blocker therapy in a mouse model of severe heart failure (2001) (258)
Recent developments in biased agonism. (2014) (258)
Structure of the adrenergic and related receptors. (1989) (254)
Alpha-adrenergic receptor subtypes. (1980) (252)
A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling. (2007) (251)
ACTH receptors in the adrenal: specific binding of ACTH-125I and its relation to adenyl cyclase. (1970) (251)
Multiple second messenger pathways of alpha-adrenergic receptor subtypes expressed in eukaryotic cells. (1990) (250)
Effector coupling mechanisms of the cloned 5-HT1A receptor. (1989) (250)
Distinct conformations of GPCR–β-arrestin complexes mediate desensitization, signaling, and endocytosis (2017) (248)
Alpha-adrenergic receptor subtypes: quantitative assessment by ligand binding. (1979) (248)
Phosphorylation of the Type 1A Angiotensin II Receptor by G Protein-coupled Receptor Kinases and Protein Kinase C* (1996) (246)
Clathrin-mediated Endocytosis of the β-Adrenergic Receptor Is Regulated by Phosphorylation/Dephosphorylation of β-Arrestin1* (1997) (244)
Regulation of beta-adrenergic receptors by guanyl-5'-yl imidodiphosphate and other purine nucleotides. (1976) (244)
Two distinct pathways for cAMP-mediated down-regulation of the beta 2-adrenergic receptor. Phosphorylation of the receptor and regulation of its mRNA level. (1989) (243)
Regulation of G protein-coupled receptor signaling by scaffold proteins. (2002) (240)
Assembly of an A kinase-anchoring protein–β2-adrenergic receptor complex facilitates receptor phosphorylation and signaling (2000) (240)
Distinct conformational changes in β-arrestin report biased agonism at seven-transmembrane receptors (2008) (240)
Direct identification and characterisation of β-adrenergic receptors in rat brain (1975) (239)
Multiple ligand-specific conformations of the β2-adrenergic receptor. (2011) (239)
Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors. (2000) (238)
Catecholamines, Cardiac b-Adrenergic Receptors, and Heart Failure (2000) (237)
Beta-adrenergic receptors in hamster smooth muscle cells are transcriptionally regulated by glucocorticoids. (1988) (237)
Arresting developments in heptahelical receptor signaling and regulation. (2002) (235)
Desensitization, internalization, and signaling functions of β-arrestins demonstrated by RNA interference (2003) (234)
The superfamily of heptahelical receptors (2000) (234)
Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins. (2002) (233)
β2-Adrenergic Receptor Signaling and Desensitization Elucidated by Quantitative Modeling of Real Time cAMP Dynamics* (2008) (233)
Negative antagonists promote an inactive conformation of the beta 2-adrenergic receptor. (1994) (231)
Regulation of β-Adrenergic Receptors by Steroid Hormones (1984) (231)
Trafficking Patterns of β-Arrestin and G Protein-coupled Receptors Determined by the Kinetics of β-Arrestin Deubiquitination* (2003) (228)
β-Arrestin-biased Agonism at the β2-Adrenergic Receptor* (2008) (228)
Identification of the G Protein-coupled Receptor Kinase Phosphorylation Sites in the Human β2-Adrenergic Receptor* (1996) (228)
β-Arrestins Regulate Protease-activated Receptor-1 Desensitization but Not Internalization or Down-regulation* (2002) (227)
Synergistic Regulation of β2-Adrenergic Receptor Sequestration: Intracellular Complement of β-Adrenergic Receptor Kinase and β-Arrestin Determine Kinetics of Internalization (1997) (226)
Enhancement of cardiac function after adenoviral-mediated in vivo intracoronary beta2-adrenergic receptor gene delivery. (1999) (225)
β-Arrestin inhibits NF-κB activity by means of its interaction with the NF-κB inhibitor IκBα (2004) (225)
GTPase Activating Specificity of RGS12 and Binding Specificity of an Alternatively Spliced PDZ (PSD-95/Dlg/ZO-1) Domain* (1998) (225)
Dopaminergic Supersensitivity in G Protein-Coupled Receptor Kinase 6-Deficient Mice (2003) (223)
Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection. (2007) (221)
ß-Arrestin 2 Mediates Endocytosis of Type III TGF-ß Receptor and Down-Regulation of Its Signaling (2003) (221)
Receptor binding studies in adrenergic pharmacology (1978) (220)
Structural basis for receptor subtype-specific regulation revealed by a chimeric beta 3/beta 2-adrenergic receptor. (1993) (220)
Control of yeast mating signal transduction by a mammalian beta 2-adrenergic receptor and Gs alpha subunit. (1990) (220)
Receptor-specific in vivo desensitization by the G protein-coupled receptor kinase-5 in transgenic mice. (1996) (219)
Role of extracellular disulfide-bonded cysteines in the ligand binding function of the beta 2-adrenergic receptor. (1990) (217)
Enhanced Myocardial Function inTransgenic Mice Overexpressing theP2-Adrenergic Receptor (1994) (216)
Delineation of the intronless nature of the genes for the human and hamster beta 2-adrenergic receptor and their putative promoter regions. (1987) (216)
Pharmacological characteristics of alpha 2-adrenergic receptors: comparison of pharmacologically defined subtypes with subtypes identified by molecular cloning. (1992) (213)
β-Arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes (2006) (213)
beta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice. (2009) (212)
G-protein -Subunits Activate Mitogen-activated Protein Kinase via a Novel Protein Kinase C-dependent Mechanism (*) (1996) (212)
Constitutively active mutants of the alpha 2-adrenergic receptor. (1993) (211)
Inhibition of thrombin receptor signaling by a G-protein coupled receptor kinase. Functional specificity among G-protein coupled receptor kinases. (1994) (210)
Preservation of myocardial β-adrenergic receptor signaling delays the development of heart failure after myocardial infarction (2000) (210)
Direct Binding of Activated c-Src to the β3-Adrenergic Receptor Is Required for MAP Kinase Activation* (2000) (209)
Platelet-Derived Growth Factor Receptor Association with Na+/H+ Exchanger Regulatory Factor Potentiates Receptor Activity (2000) (209)
G Protein-coupled Receptors Mediate Two Functionally Distinct Pathways of Tyrosine Phosphorylation in Rat 1a Fibroblasts (1997) (207)
Phorbol diesters promote beta-adrenergic receptor phosphorylation and adenylate cyclase desensitization in duck erythrocytes. (1984) (205)
Muscarinic Supersensitivity and Impaired Receptor Desensitization in G Protein–Coupled Receptor Kinase 5–Deficient Mice (1999) (204)
Restoration of beta-adrenergic signaling in failing cardiac ventricular myocytes via adenoviral-mediated gene transfer. (1997) (203)
Phosphorylation/dephosphorylation of the beta-adrenergic receptor regulates its functional coupling to adenylate cyclase and subcellular distribution. (1986) (203)
Role of acidic amino acids in peptide substrates of the beta-adrenergic receptor kinase and rhodopsin kinase. (1991) (203)
In Vivo Ventricular Gene Delivery of a &bgr;-Adrenergic Receptor Kinase Inhibitor to the Failing Heart Reverses Cardiac Dysfunction (2001) (201)
Characterization of the G Protein-coupled Receptor Kinase GRK4 (1996) (201)
Mechanisms of beta-adrenergic receptor desensitization and resensitization. (1998) (201)
Overexpression of beta-arrestin and beta-adrenergic receptor kinase augment desensitization of beta 2-adrenergic receptors. (1993) (200)
Allosteric Nanobodies Reveal the Dynamic Range and Diverse Mechanisms of GPCR Activation (2016) (200)
Subsensitivity of adenylate cyclase and decreased beta-adrenergic receptor binding after chronic exposure to (minus)-isoproterenol in vitro. (1975) (200)
Arrestin development: emerging roles for beta-arrestins in developmental signaling pathways. (2009) (198)
Corticosteroid-induced differential regulation of beta-adrenergic receptors in circulating human polymorphonuclear leukocytes and mononuclear leukocytes. (1980) (195)
Enhanced Rewarding Properties of Morphine, but not Cocaine, in βarrestin-2 Knock-Out Mice (2003) (195)
Alterations in cardiac adrenergic signaling and calcium cycling differentially affect the progression of cardiomyopathy. (2001) (194)
Beta-adrenergic receptor kinase-2 and beta-arrestin-2 as mediators of odorant-induced desensitization. (1993) (194)
A brief history of G-protein coupled receptors (Nobel Lecture). (2013) (194)
Quantitative resolution of beta-adrenergic receptor subtypes by selective ligand binding: application of a computerized model fitting technique. (1979) (192)
Feedback Inhibition of G Protein-coupled Receptor Kinase 2 (GRK2) Activity by Extracellular Signal-regulated Kinases* (1999) (191)
β-Arrestin1 Interacts with the Catalytic Domain of the Tyrosine Kinase c-SRC (2000) (191)
Gβγ Subunits Mediate Mitogen-activated Protein Kinase Activation by the Tyrosine Kinase Insulin-like Growth Factor 1 Receptor (*) (1995) (190)
Dancing with different partners: protein kinase a phosphorylation of seven membrane-spanning receptors regulates their G protein-coupling specificity. (2002) (190)
Phosphatidylinositol 4,5-Bisphosphate (PIP2)-enhanced G Protein-coupled Receptor Kinase (GRK) Activity: LOCATION, STRUCTURE, AND REGULATION OF THE PIP2 BINDING SITE DISTINGUISHES THE GRK SUBFAMILIES* (1996) (189)
The mammalian beta 2-adrenergic receptor: reconstitution of functional interactions between pure receptor and pure stimulatory nucleotide binding protein of the adenylate cyclase system. (1984) (189)
Stereospecific 63H9(?)-alprenolol binding sites, ?-adrenergic receptors and adenylate cyclase (1974) (189)
Identification, purification, and characterization of GRK5, a member of the family of G protein-coupled receptor kinases. (1994) (189)
Phosphorylation and Desensitization of Human Endothelin A and B Receptors (1997) (188)
Control of Myocardial Contractile Function by the Level of β-Adrenergic Receptor Kinase 1 in Gene-targeted Mice* (1998) (187)
Global phosphorylation analysis of β-arrestin–mediated signaling downstream of a seven transmembrane receptor (7TMR) (2010) (187)
cAMP stimulates transcription of the beta 2-adrenergic receptor gene in response to short-term agonist exposure. (1989) (187)
Desensitization of the isolated beta 2-adrenergic receptor by beta-adrenergic receptor kinase, cAMP-dependent protein kinase, and protein kinase C occurs via distinct molecular mechanisms. (1992) (185)
Molecular biology of α-adrenergic receptors: implications for receptor classification and for structure-function relationships (1991) (185)
A β-Arrestin–Biased Agonist of the Parathyroid Hormone Receptor (PTH1R) Promotes Bone Formation Independent of G Protein Activation (2009) (184)
Protein Kinase A-mediated Phosphorylation of the β2-Adrenergic Receptor Regulates Its Coupling to Gs and Gi (2002) (184)
beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi. (2003) (182)
Beta-arrestin-2 regulates the development of allergic asthma. (2003) (182)
The G-protein-coupled receptor phosphatase: a protein phosphatase type 2A with a distinct subcellular distribution and substrate specificity. (1995) (182)
β-Arrestin-mediated ADP-ribosylation Factor 6 Activation and β2-Adrenergic Receptor Endocytosis* (2001) (181)
Constitutive Protease-activated Receptor-2-mediated Migration of MDA MB-231 Breast Cancer Cells Requires Both β-Arrestin-1 and -2* (2004) (181)
Differential Regulation of Dopamine D1A Receptor Responsiveness by Various G Protein-coupled Receptor Kinases (*) (1996) (180)
Mutagenesis of the beta 2-adrenergic receptor: how structure elucidates function. (1992) (180)
Reciprocal Regulation of Angiotensin Receptor-activated Extracellular Signal-regulated Kinases by β-Arrestins 1 and 2* (2004) (180)
Human cardiac beta-adrenergic receptors: subtype heterogeneity delineated by direct radioligand binding. (1983) (179)
Cloning, expression, and chromosomal localization of beta-adrenergic receptor kinase 2. A new member of the receptor kinase family. (1991) (177)
Regulation of Membrane Targeting of the G Protein-coupled Receptor Kinase 2 by Protein Kinase A and Its Anchoring Protein AKAP79* (2001) (176)
β-Arrestin1 Mediates Insulin-like Growth Factor 1 (IGF-1) Activation of Phosphatidylinositol 3-Kinase (PI3K) and Anti-apoptosis* (2003) (175)
Identification of adenylate cyclase-coupled beta-adrenergic receptors in frog erythrocytes with (minus)-[3-H] alprenolol. (1975) (175)
Regulation of adrenergic receptor function by phosphorylation. II. Effects of agonist occupancy on phosphorylation of alpha 1- and beta 2-adrenergic receptors by protein kinase C and the cyclic AMP-dependent protein kinase. (1987) (175)
Guanine nucleotides modulate the binding affinity of the oligopeptide chemoattractant receptor on human polymorphonuclear leukocytes. (1983) (174)
Catecholamine-induced desensitization of turkey erythrocyte adenylate cyclase is associated with phosphorylation of the beta-adrenergic receptor. (1983) (173)
Epidermal Growth Factor (EGF) Receptor-dependent ERK Activation by G Protein-coupled Receptors (2001) (173)
Receptor-specific Ubiquitination of β-Arrestin Directs Assembly and Targeting of Seven-transmembrane Receptor Signalosomes* (2005) (172)
Localization of mRNA for three distinct alpha 1-adrenergic receptor subtypes in human tissues: implications for human alpha-adrenergic physiology. (1994) (172)
β-Arrestin-dependent Constitutive Internalization of the Human Chemokine Decoy Receptor D6* (2004) (172)
Comparative rates of desensitization of beta-adrenergic receptors by the beta-adrenergic receptor kinase and the cyclic AMP-dependent protein kinase. (1991) (171)
Relative opioid efficacy is determined by the complements of the G protein-coupled receptor desensitization machinery. (2004) (171)
β-Adrenergic receptors: Evidence for negative cooperativity (1975) (170)
G Protein-coupled Receptor Kinase 3 (GRK3) Gene Disruption Leads to Loss of Odorant Receptor Desensitization* (1997) (170)
The G Protein-coupled Receptor Kinase 2 Is a Microtubule-associated Protein Kinase That Phosphorylates Tubulin* (1998) (168)
Slowly reversible binding of catecholamine to a nucleotide-sensitive state of the beta-adrenergic receptor. (1977) (168)
Light-dependent phosphorylation of rhodopsin by β-adrenergic receptor kinase (1986) (168)
Isoprenylation of a protein kinase. Requirement of farnesylation/alpha-carboxyl methylation for full enzymatic activity of rhodopsin kinase. (1992) (167)
Functional consequences of altering myocardial adrenergic receptor signaling. (2000) (167)
Gβγ interactions with PH domains and Ras-MAPK signaling pathways (1995) (166)
Identification of alpha-adrenergic receptors in uterine smooth muscle membranes by [3H]dihydroergocryptine binding. (1976) (166)
Beta adrenergic and muscarinic cholinergic receptors in canine myocardium. Effects of ischemia. (1979) (166)
Identification of α-Adrenergic Receptors in Human Platelets by [3H]Dihydroergocryptine Binding (1978) (165)
The multiple membrane spanning topography of the beta 2-adrenergic receptor. Localization of the sites of binding, glycosylation, and regulatory phosphorylation by limited proteolysis. (1987) (165)
The mammalian beta 2-adrenergic receptor: purification and characterization. (1984) (164)
Agonist-promoted coupling of the beta-adrenergic receptor with the guanine nucleotide regulatory protein of the adenylate cyclase system. (1980) (164)
Regulation of adrenergic receptor responsiveness through modulation of receptor gene expression. (1991) (163)
S-nitrosylation of beta-arrestin regulates beta-adrenergic receptor trafficking. (2008) (162)
Heterogeneity of radioligand binding to alpha-adrenergic receptors. Analysis of guanine nucleotide regulation of agonist binding in relation to receptor subtypes. (1980) (161)
Structure of the M2 muscarinic receptor-β-arrestin complex in a lipid nanodisc (2020) (160)
The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange. (1998) (160)
β-Arrestin Is Crucial for Ubiquitination and Down-regulation of the Insulin-like Growth Factor-1 Receptor by Acting as Adaptor for the MDM2 E3 Ligase* (2005) (159)
Specificity of the functional interactions of the beta-adrenergic receptor and rhodopsin with guanine nucleotide regulatory proteins reconstituted in phospholipid vesicles. (1985) (158)
Identification of cardiac beta-adrenergic receptors by (minus) [3H]alprenolol binding. (1975) (156)
Solubilization and characterization of the beta-adrenergic receptor binding sites of frog erythrocytes. (1976) (156)
GIT Proteins, A Novel Family of Phosphatidylinositol 3,4,5-Trisphosphate-stimulated GTPase-activating Proteins for ARF6* (2000) (156)
Protein Kinase A and G Protein-coupled Receptor Kinase Phosphorylation Mediates β-1 Adrenergic Receptor Endocytosis through Different Pathways* (2003) (156)
Beta adrenergic receptors in lymphocyte subpopulations. (1980) (155)
Defective lymphocyte chemotaxis in beta-arrestin2- and GRK6-deficient mice. (2002) (155)
β1-Adrenergic Receptor Association with PSD-95 (2000) (153)
Distribution of alpha 2-adrenergic receptor subtype gene expression in rat brain. (1994) (152)
β-Arrestins Regulate Mitogenic Signaling and Clathrin-mediated Endocytosis of the Insulin-like Growth Factor I Receptor* (1998) (152)
Regulation of prostaglandin receptors by prostaglandins and guanine nucleotides in frog erythrocytes. (1977) (152)
Regulation of adrenergic receptor function by phosphorylation. I. Agonist-promoted desensitization and phosphorylation of alpha 1-adrenergic receptors coupled to inositol phospholipid metabolism in DDT1 MF-2 smooth muscle cells. (1987) (151)
Seven-Transmembrane Receptor Signaling Through β-Arrestin (2005) (151)
Binding of the β2 Adrenergic Receptor toN-Ethylmaleimide-sensitive Factor Regulates Receptor Recycling* (2001) (151)
Functional reconstitution of the alpha 2-adrenergic receptor with guanine nucleotide regulatory proteins in phospholipid vesicles. (1986) (151)
Neuropathic Pain Activates the Endogenous κ Opioid System in Mouse Spinal Cord and Induces Opioid Receptor Tolerance (2004) (150)
The receptor kinase family: primary structure of rhodopsin kinase reveals similarities to the beta-adrenergic receptor kinase. (1991) (150)
Desensitization of the beta-adrenergic receptor of frog erythrocytes. Recovery and characterization of the down-regulated receptors in sequestered vesicles. (1983) (150)
Serotonin 5-HT1A Receptor-mediated Erk Activation Requires Calcium/Calmodulin-dependent Receptor Endocytosis* (1999) (150)
β-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation*S⃞ (2009) (148)
Regulation of hormone receptors and adenylyl cyclases by guanine nucleotide binding N proteins. (1985) (148)
Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the beta1-adrenergic receptor. (1999) (148)
Src-dependent Tyrosine Phosphorylation Regulates Dynamin Self-assembly and Ligand-induced Endocytosis of the Epidermal Growth Factor Receptor* (2002) (147)
Regulation of rabbit myometrial alpha adrenergic receptors by estrogen and progesterone. (1977) (147)
Oxygen-Regulated β2-Adrenergic Receptor Hydroxylation by EGLN3 and Ubiquitylation by pVHL (2009) (147)
The substance P receptor, which couples to Gq/11, is a substrate of beta-adrenergic receptor kinase 1 and 2. (1993) (146)
Palmitoylation of G protein-coupled receptor kinase, GRK6. Lipid modification diversity in the GRK family. (1994) (145)
β-Arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2 (2009) (144)
A small region of the beta-adrenergic receptor is selectively involved in its rapid regulation. (1991) (144)
The alpha 1C-adrenergic receptor: characterization of signal transduction pathways and mammalian tissue heterogeneity. (1991) (144)
Regulation of V2 Vasopressin Receptor Degradation by Agonist-promoted Ubiquitination* (2003) (144)
Feedback Regulation of β-Arrestin1 Function by Extracellular Signal-regulated Kinases* (1999) (144)
Agonist-specific effects of monovalent and divalent cations on adenylate cyclase-coupled alpha adrenergic receptors in rabbit platelets. (1978) (144)
Radioreceptor Assay of Adrenocorticotropic Hormone: New Approach to Assay of Polypeptide Hormones in Plasma (1970) (144)
Transgenic Mice with Cardiac Overexpression of α1B-Adrenergic Receptors (1997) (143)
Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9 (2018) (143)
Targeting of Diacylglycerol Degradation to M1 Muscarinic Receptors by ß-Arrestins (2007) (143)
beta-arrestins: traffic cops of cell signaling. (2004) (143)
Spinophilin Blocks Arrestin Actions in Vitro and in Vivo at G Protein-Coupled Receptors (2004) (143)
Regulation of adrenergic receptor function by phosphorylation (1986) (143)
Identification of a Motif in the Carboxyl Terminus of β-Arrestin2 Responsible for Activation of JNK3* (2001) (142)
Angiotensin Analogs with Divergent Bias Stabilize Distinct Receptor Conformations (2019) (141)
Agonist-specific effects of guanine nucleotides on alpha-adrenergic receptors in human platelets. (1979) (141)
G Protein-coupled Receptor Kinase 6A Phosphorylates the Na+/H+ Exchanger Regulatory Factor via a PDZ Domain-mediated Interaction* (1999) (141)
The oligopeptide chemotactic factor receptor on human polymorphonuclear leukocyte membranes exists in two affinity states. (1982) (140)
Structural basis of beta-adrenergic receptor subtype specificity studied with chimeric beta 1/beta 2-adrenergic receptors. (1988) (140)
The GIT Family of ADP-ribosylation Factor GTPase-activating Proteins (2000) (140)
β-Arrestin 1 and Gαq/11 Coordinately Activate RhoA and Stress Fiber Formation following Receptor Stimulation* (2005) (138)
Magnesium dependence of agonist binding to adenylate cyclase-coupled hormone receptors. (1978) (137)
Discrete amino acid sequences of the alpha 1-adrenergic receptor determine the selectivity of coupling to phosphatidylinositol hydrolysis. (1992) (136)
Molecular basis for interactions of G protein betagamma subunits with effectors. (1998) (136)
Pharmacological Characterization of Membrane-Expressed Human Trace Amine-Associated Receptor 1 (TAAR1) by a Bioluminescence Resonance Energy Transfer cAMP Biosensor (2008) (135)
From ligand binding to gene expression: new insights into the regulation of G-protein-coupled receptors. (1992) (135)
Effects of Calcium on ACTH Stimulation of the Adrenal: Separation of Hormone Binding from Adenyl Cyclase Activation (1970) (135)
A constitutively active mutant beta 2-adrenergic receptor is constitutively desensitized and phosphorylated. (1994) (134)
Potentiation of beta-adrenergic signaling by adenoviral-mediated gene transfer in adult rabbit ventricular myocytes. (1997) (133)
The ß-adrenergic receptor and adenylate cyclase (1976) (133)
Identification of NSF as a β-Arrestin1-binding Protein (1999) (132)
Subclassification of alpha-adrenergic receptors by direct binding studies. (1979) (132)
Expression of three alpha 2-adrenergic receptor subtypes in rat tissues: implications for alpha 2 receptor classification. (1990) (132)
A cAMP response element in the beta 2-adrenergic receptor gene confers transcriptional autoregulation by cAMP. (1990) (132)
Direct binding studies of adrenergic receptors: biochemical, physiologic, and clinical implications. (1979) (131)
The beta(2)-adrenergic receptor mediates extracellular signal-regulated kinase activation via assembly of a multi-receptor complex with the epidermal growth factor receptor. (2000) (131)
Adipocyte beta-adrenergic receptors. Identification and subcellular localization by (-)-[3H]dihydroalprenolol binding. (1976) (131)
β-Arrestin 2-Dependent Angiotensin II Type 1A Receptor-Mediated Pathway of Chemotaxis (2005) (131)
A high affinity agonist . beta-adrenergic receptor complex is an intermediate for catecholamine stimulation of adenylate cyclase in turkey and frog erythrocyte membranes. (1980) (131)
Prospects for cardiovascular research. (2001) (131)
Smoothened Signal Transduction Is Promoted by G Protein-Coupled Receptor Kinase 2 (2006) (130)
beta-Arrestin inhibits NF-kappaB activity by means of its interaction with the NF-kappaB inhibitor IkappaBalpha. (2004) (130)
Intracoronary adenovirus-mediated delivery and overexpression of the beta(2)-adrenergic receptor in the heart : prospects for molecular ventricular assistance. (2000) (129)
β-Arrestin-mediated Recruitment of the Src Family Kinase Yes Mediates Endothelin-1-stimulated Glucose Transport* (2001) (129)
Role of c-Src tyrosine kinase in G protein-coupled receptor- and Gbetagamma subunit-mediated activation of mitogen-activated protein kinases. (1996) (128)
Ubiquitination of β-Arrestin Links Seven-transmembrane Receptor Endocytosis and ERK Activation* (2007) (128)
Molecular mechanisms of G protein-coupled receptor signaling: role of G protein-coupled receptor kinases and arrestins in receptor desensitization and resensitization. (1997) (128)
A beta-adrenergic receptor kinase-like enzyme is involved in olfactory signal termination. (1993) (127)
Activation-dependent Conformational Changes in β-Arrestin 2* (2004) (127)
Purification of the beta-adrenergic receptor. Identification of the hormone binding subunit. (1981) (126)
Overview of the Alliance for Cellular Signaling (2002) (125)
Mutations of the human beta 2-adrenergic receptor that impair coupling to Gs interfere with receptor down-regulation but not sequestration. (1991) (123)
Beta-Arrestins: new roles in regulating heptahelical receptors' functions. (2001) (123)
Mechanism of intracellular allosteric β2AR antagonist revealed by X-ray crystal structure (2017) (123)
G-protein-coupled Receptor Kinase Specificity for β-Arrestin Recruitment to the β2-Adrenergic Receptor Revealed by Fluorescence Resonance Energy Transfer* (2006) (123)
Chromosomal organization of adrenergic receptor genes. (1990) (122)
Trafficking patterns of beta-arrestin and G protein-coupled receptors determined by the kinetics of beta-arrestin deubiquitination. (2003) (121)
Seven-transmembrane receptor signaling through beta-arrestin. (2005) (121)
Reciprocal modulation of agonist and antagonist binding to muscarinic cholinergic receptor by guanine nucleotide. (1982) (121)
Prolonged Kappa Opioid Receptor Phosphorylation Mediated by G-protein Receptor Kinase Underlies Sustained Analgesic Tolerance* (2004) (121)
Beta-agonist- and prostaglandin E1-induced translocation of the beta-adrenergic receptor kinase: evidence that the kinase may act on multiple adenylate cyclase-coupled receptors. (1986) (119)
Molecular mechanism of biased signaling in a prototypical G protein–coupled receptor (2020) (118)
A mutation of the beta 2-adrenergic receptor impairs agonist activation of adenylyl cyclase without affecting high affinity agonist binding. Distinct molecular determinants of the receptor are involved in physical coupling to and functional activation of Gs. (1990) (117)
The active conformation of beta-arrestin1: direct evidence for the phosphate sensor in the N-domain and conformational differences in the active states of beta-arrestins1 and -2. (2007) (117)
Affinity chromatography of the beta-adrenergic receptor. (1979) (117)
Beta-arrestin 2 mediates endocytosis of type III TGF-beta receptor and down-regulation of its signaling. (2003) (117)
Anti-beta(1)-adrenergic receptor antibodies and heart failure: causation, not just correlation. (2004) (117)
G-protein-coupled Receptor (GPCR) Kinase Phosphorylation and β-Arrestin Recruitment Regulate the Constitutive Signaling Activity of the Human Cytomegalovirus US28 GPCR* (2003) (116)
G protein beta gamma subunits stimulate phosphorylation of Shc adapter protein. (1995) (116)
Alpha adrenergic receptor subtypes in rabbit uterus: mediation of myometrial contraction and regulation by estrogens. (1981) (116)
Alpha-adrenergic receptor identification by (3H)dihydroergocryptine binding. (1976) (114)
Regulation of β2-Adrenergic Receptor Function by Conformationally Selective Single-Domain Intrabodies (2014) (113)
Distinctive Activation Mechanism for Angiotensin Receptor Revealed by a Synthetic Nanobody (2019) (113)
Desensitization of turkey erythrocyte adenylate cyclase. Beta-adrenergic receptor phosphorylation is correlated with attenuation of adenylate cyclase activity. (1984) (112)
Agonist-dependent phosphorylation of the α2-adrenergic receptor by the β-adrenergic receptor kinase (1987) (112)
N-Formyl Peptide Receptors Internalize but Do Not Recycle in the Absence of Arrestins* (2003) (112)
Coupling of a mutated form of the human beta 2-adrenergic receptor to Gi and Gs. Requirement for multiple cytoplasmic domains in the coupling process. (1991) (112)
beta-arrestin-biased agonism at the beta2-adrenergic receptor. (2008) (110)
Identification and sequence of a binding site peptide of the beta 2-adrenergic receptor. (1988) (109)
β-Arrestin and Mdm2 Mediate IGF-1 Receptor-stimulated ERK Activation and Cell Cycle Progression* (2007) (108)
Regulation of Adenylate Cyclase Coupled β-Adrenergic Receptors by β-Adrenergic Catecholamines (1976) (108)
Negative cooperativity among beta-adrenergic receptors in frog erythrocyte membranes. (1976) (108)
Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR (2020) (108)
Antagonism of catecholamine receptor signaling by expression of cytoplasmic domains of the receptors. (1993) (108)
Resolution of beta-adrenergic receptor binding and adenylate cyclase activity by gel exclusion chromatography. (1977) (108)
Activation of the cloned muscarinic potassium channel by G protein beta gamma subunits. (1994) (107)
Sites in the third intracellular loop of the alpha 2A-adrenergic receptor confer short term agonist-promoted desensitization. Evidence for a receptor kinase-mediated mechanism. (1992) (107)
Pharmacological characterizations of adrenergic receptors in human adipocytes. (1981) (106)
Receptor-tyrosine-kinase- and G beta gamma-mediated MAP kinase activation by a common signalling pathway. (1995) (106)
beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation. (2005) (106)
Differential regulation of the α2-adrenergic receptor by Na+ and guanine nucleotides (1980) (106)
Independent β-Arrestin2 and Gq/Protein Kinase Cζ Pathways for ERK Stimulated by Angiotensin Type 1A Receptors in Vascular Smooth Muscle Cells Converge on Transactivation of the Epidermal Growth Factor Receptor* (2009) (106)
Homologous desensitization of adenylate cyclase is associated with phosphorylation of the beta-adrenergic receptor. (1985) (105)
Ras-dependent activation of fibroblast mitogen-activated protein kinase by 5-HT1A receptor via a G protein beta gamma-subunit-initiated pathway. (1996) (105)
A novel catecholamine-activated adenosine cyclic 3',5'-phosphate independent pathway for beta-adrenergic receptor phosphorylation in wild-type and mutant S49 lymphoma cells: mechanism of homologous desensitization of adenylate cyclase. (1986) (105)
beta-Adrenergic receptor kinase. Activity of partial agonists for stimulation of adenylate cyclase correlates with ability to promote receptor phosphorylation. (1988) (105)
Functional activity and regulation of human beta 2-adrenergic receptors expressed in Xenopus oocytes. (1987) (104)
PKA-mediated phosphorylation of the beta1-adrenergic receptor promotes Gs/Gi switching. (2004) (104)
Mutational Analysis of the Pleckstrin Homology Domain of the β-Adrenergic Receptor Kinase. (1995) (103)
When 7 transmembrane receptors are not G protein-coupled receptors. (2005) (103)
Phosphorylation of chick heart muscarinic cholinergic receptors by the beta-adrenergic receptor kinase. (1989) (103)
Agonist-promoted high affinity state of the beta-adrenergic receptor in human neutrophils: modulation by corticosteroids. (1981) (103)
Reconstitution of a hormone-sensitive adenylate cyclase system. The pure beta-adrenergic receptor and guanine nucleotide regulatory protein confer hormone responsiveness on the resolved catalytic unit. (1984) (102)
Conformation Guides Molecular Efficacy in Docking Screens of Activated β-2 Adrenergic G Protein Coupled Receptor (2013) (101)
Catecholamines, cardiac beta-adrenergic receptors, and heart failure. (2000) (101)
Catecholamine binding to the beta-adrenergic receptor. (1977) (101)
β-Arrestin-mediated Signaling Regulates Protein Synthesis* (2008) (101)
Cardiac beta ARK1 inhibition prolongs survival and augments beta blocker therapy in a mouse model of severe heart failure. (2001) (101)
Specific binding of -adrenergic catecholamines to a subcellular fraction from cardiac muscle. (1973) (100)
Structure of an Endosomal Signaling GPCR–G Protein–β-arrestin Mega-Complex (2019) (99)
Phosphorylation of cell surface receptors: a mechanism for regulating signal transduction pathways. (1988) (99)
GIPC Interacts with the β1-Adrenergic Receptor and Regulates β1-Adrenergic Receptor-mediated ERK Activation* (2003) (99)
Inhibition of beta-adrenergic receptor kinase prevents rapid homologous desensitization of beta 2-adrenergic receptors. (1989) (98)
Alpha-adrenergic receptors in liver membranes: delineation with subtype selective radioligands. (1981) (98)
Pure β-adrenergic receptor: the single polypeptide confers catecholamine responsiveness to adenylate cyclase (1983) (98)
Mammalian beta-adrenergic receptors. Distinct glycoprotein populations containing high mannose or complex type carbohydrate chains. (1984) (98)
Allosteric “beta-blocker” isolated from a DNA-encoded small molecule library (2017) (98)
Odorant Receptors and Desensitization Proteins Colocalize in Mammalian Sperm (1995) (98)
Gβγ Subunits Mediate Src-dependent Phosphorylation of the Epidermal Growth Factor Receptor (1997) (98)
In Vivo Inhibition of Elevated Myocardial β-Adrenergic Receptor Kinase Activity in Hybrid Transgenic Mice Restores Normal β-Adrenergic Signaling and Function (1999) (98)
Adenylate cyclase-coupled beta adrenergic receptors effect of membrane lipid-perturbing agents on receptor binding and enzyme stimulation by catecholamines. (1976) (97)
G Protein-Coupled Receptor Kinase Function Is Essential for Chemosensation in C. elegans (2004) (97)
Unique uncoupling of the frog erythrocyte adenylate cyclase system by manganese. Loss of hormone and guanine nucleotide-sensitive enzyme activities without loss of nucleotide-sensitive, high affinity agonist binding. (1979) (97)
Adrenergic receptors. Models for regulation of signal transduction processes. (1990) (97)
Stimulation of catecholamine-sensitive adenylate cyclase by 5'-guanylyl-imidodiphosphate. (1974) (97)
Divergent Transducer-specific Molecular Efficacies Generate Biased Agonism at a G Protein-coupled Receptor (GPCR)* (2014) (96)
Phosphorylation of beta-arrestin2 regulates its function in internalization of beta(2)-adrenergic receptors. (2002) (95)
Augmentation of Cardiac Contractility Mediated by the Human &bgr;3-Adrenergic Receptor Overexpressed in the Hearts of Transgenic Mice (2001) (95)
Hormones, receptors, and cyclic AMP: their role in target cell refractoriness. (1980) (95)
Regulation of adenylate cyclase-coupled beta adrenergic receptor binding sites by beta adrenergic catecholamines in vitro. (1976) (94)
Arresting a Transient Receptor Potential (TRP) Channel (2010) (94)
Agonist versus antagonist binding to alpha-adrenergic receptors. (1980) (94)
G‐protein receptor kinase 3 (GRK3) influences opioid analgesic tolerance but not opioid withdrawal (2004) (94)
reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation. (2016) (94)
Olfactory desensitization requires membrane targeting of receptor kinase mediated by beta gamma-subunits of heterotrimeric G proteins. (1994) (93)
Involvement of tyrosine residues located in the carboxyl tail of the human beta 2-adrenergic receptor in agonist-induced down-regulation of the receptor. (1990) (92)
Members of the G protein-coupled receptor kinase family that phosphorylate the beta2-adrenergic receptor facilitate sequestration. (1996) (92)
Inhibition of G protein-coupled receptor signaling by expression of cytoplasmic domains of the receptor. (1994) (92)
Interactions of Agonists with Platelet α2-Adrenergic Receptors (1982) (91)
The beta 1-adrenergic receptor of the turkey erythrocyte. Molecular heterogeneity revealed by purification and photoaffinity labeling. (1982) (90)
Differential desensitization and phosphorylation of three cloned and transfected alpha 2-adrenergic receptor subtypes. (1994) (90)
Alpha‐Adrenergic Receptors in Rat Myocardium: Identification by Binding of [3H]Dihydroergocryptine (1978) (90)
The kinase Grk2 regulates Nedd4/Nedd4-2-dependent control of epithelial Na+ channels. (2004) (89)
The GRK4 Subfamily of G Protein-coupled Receptor Kinases (1999) (88)
beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis. (2001) (88)
Saving the Endangered Physician-Scientist - A Plan for Accelerating Medical Breakthroughs. (2019) (88)
Agonist-induced increase in apparent β-adrenergic receptor size (1978) (88)
&bgr;-Arrestins Regulate Atherosclerosis and Neointimal Hyperplasia by Controlling Smooth Muscle Cell Proliferation and Migration (2008) (87)
ACTH‐RECEPTOR INTERACTION IN THE ADRENAL: A MODEL FOR THE INITIAL STEP IN THE ACTION OF HORMONES THAT STIMULATE ADENYL CYCLASE (1971) (87)
Heterogeneity of adenylate cyclase-coupled β-adrenergic receptors (1975) (87)
Targeting Gbeta gamma signaling in arterial vascular smooth muscle proliferation: a novel strategy to limit restenosis. (1999) (87)
β-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins (2001) (87)
Tyrosine phosphorylation of G protein alpha subunits by pp60c-src. (1992) (86)
Enhanced myocardial relaxation in vivo in transgenic mice overexpressing the beta2-adrenergic receptor is associated with reduced phospholamban protein. (1996) (85)
β-Arrestin Deficiency Protects Against Pulmonary Fibrosis in Mice and Prevents Fibroblast Invasion of Extracellular Matrix (2011) (84)
β-Adrenergic Receptor Kinase-1 Levels in Catecholamine-Induced Myocardial Hypertrophy Regulation by β- but not α1-Adrenergic Stimulation (1999) (84)
Competing G protein-coupled receptor kinases balance G protein and β-arrestin signaling (2012) (84)
Conformational Basis of G Protein-Coupled Receptor Signaling Versatility. (2020) (84)
A role for Ni in the hormonal stimulation of adenylate cyclase (1985) (84)
Pineal beta adrenergic receptor: correlation of binding of 3H-l-alprenolol with stimulation of adenylate cyclase. (1976) (84)
21 G-protein-coupled receptors and their regulation (1997) (83)
Molecular mechanisms of coupling in hormone receptor-adenylate cyclase systems. (1982) (83)
In vitro desensitization of beta adrenergic receptors in human neutrophils. Attenuation by corticosteroids. (1983) (83)
Hybrid transgenic mice reveal in vivo specificity of G protein-coupled receptor kinases in the heart. (2000) (83)
Role of alpha 1 adrenoceptors in the turnover of phosphatidylinositol and of alpha 2 adrenoceptors in the regulation of cyclic AMP accumulation in hamster adipocytes. (1980) (83)
Effect of Cellular Expression of Pleckstrin Homology Domains on Gi-coupled Receptor Signaling(*) (1995) (82)
Loss of beta-adrenergic receptor-guanine nucleotide regulatory protein interactions accompanies decline in catecholamine responsiveness of adenylate cyclase in maturing rat erythrocytes. (1980) (82)
G-protein-coupled receptors and their regulation: activation of the MAP kinase signaling pathway by G-protein-coupled receptors. (1997) (82)
Beta-arrestin and Mdm2 mediate IGF-1 receptor-stimulated ERK activation and cell cycle progression. (2007) (82)
Structure-activity relationships of adenylate cyclase-coupled beta adrenergic receptors: determination by direct binding studies. (1976) (80)
The sustainability of interactions between the orexin-1 receptor and beta-arrestin-2 is defined by a single C-terminal cluster of hydroxy amino acids and modulates the kinetics of ERK MAPK regulation. (2005) (80)
Turned on to ill effect (1993) (79)
Homo- and Hetero-oligomerization of Thyrotropin-releasing Hormone (TRH) Receptor Subtypes (2002) (79)
Functional interactions of recombinant alpha 2 adrenergic receptor subtypes and G proteins in reconstituted phospholipid vesicles. (1991) (79)
Thyroid Hormone Regulation of Alpha‐Adrenergic Receptors: Studies in Rat Myocardium (1979) (78)
Desensitization of beta-adrenergic receptors by beta-adrenergic agonists in a cell-free system: resensitization by guanosine 5'-(beta, gamma-imino)triphosphate and other purine nucleotides. (1976) (78)
alpha-Adrenergic receptors in rat parotid cells. II. Desensitization of receptor binding sites and potassium release. (1977) (77)
Stable Interaction between β-Arrestin 2 and Angiotensin Type 1A Receptor Is Required for β-Arrestin 2-mediated Activation of Extracellular Signal-regulated Kinases 1 and 2* (2004) (77)
Dual coupling of the cloned 5-HT1A receptor to both adenylyl cyclase and phospholipase C is mediated via the same Gi protein. (1991) (77)
β-Adrenergic Receptors: Recognition and Regulation (1976) (76)
Thyroxine and Propylthiouracil Effects on Alpha- and Beta‐Adrenergic Receptor Number, ATPase Activities, and Sialic Acid Content of Rat Cardiac Membrane Vesicles (1979) (76)
Somatostatin induces translocation of the beta-adrenergic receptor kinase and desensitizes somatostatin receptors in S49 lymphoma cells. (1987) (76)
Catecholamine receptors: structure, function, and regulation. (1993) (75)
Increased Acute Inflammation, Leukotriene B4-Induced Chemotaxis, and Signaling in Mice Deficient for G Protein-Coupled Receptor Kinase 6 (2003) (75)
Identification of the cardiac beta-adrenergic receptor protein: solubilization and purification by affinity chromatography. (1972) (75)
G-protein-coupled receptors: regulatory role of receptor kinases and arrestin proteins. (1992) (75)
Regulation of adrenergic receptor function by phosphorylation. (1986) (74)
Chronic guanethidine treatment increases cardiac β-adrenergic receptors (1978) (74)
Functionally active targeting domain of the beta-adrenergic receptor kinase: an inhibitor of G beta gamma-mediated stimulation of type II adenylyl cyclase. (1994) (73)
Inhibition of the beta-adrenergic receptor kinase by polyanions. (1989) (73)
Determination of the G beta gamma-binding domain of phosducin. A regulatable modulator of G beta gamma signaling. (1994) (73)
Overexpression of the cardiac beta(2)-adrenergic receptor and expression of a beta-adrenergic receptor kinase-1 (betaARK1) inhibitor both increase myocardial contractility but have differential effects on susceptibility to ischemic injury. (1999) (72)
Adrenergic receptors in the heart. (1982) (72)
Selective alteration in high affinity agonist binding: a mechanism of beta-adrenergic receptor desensitization. (1979) (72)
Multiple reactive sulfhydryl groups modulate the function of adenylate cyclase coupled beta-adrenergic receptors. (1979) (71)
Beta-adrenergic receptors: evidence for negative cooperativity. (1975) (71)
G Protein-coupled Receptor Kinase and β-Arrestin-mediated Desensitization of the Angiotensin II Type 1A Receptor Elucidated by Diacylglycerol Dynamics* (2006) (70)
Desensitization of the turkey erythrocyte beta-adrenergic receptor in a cell-free system. Evidence that multiple protein kinases can phosphorylate and desensitize the receptor. (1985) (69)
Cardiac function in genetically engineered mice with altered adrenergic receptor signaling. (1997) (69)
Purification and characterization of the human platelet alpha 2-adrenergic receptor. (1986) (69)
Identification and regulation of alpha- and beta-adrenergic receptors. (1978) (68)
Expression of a human cDNA encoding the beta 2-adrenergic receptor in Chinese hamster fibroblasts (CHW): functionality and regulation of the expressed receptors. (1988) (68)
Phorbol diester treatment promotes enhanced adenylate cyclase activity in frog erythrocytes. (1986) (68)
Phosphatidylinositol 3-kinase is an early intermediate in the G beta gamma-mediated mitogen-activated protein kinase signaling pathway. (1996) (68)
Altered patterns of agonist-stimulated cAMP accumulation in cells expressing mutant beta 2-adrenergic receptors lacking phosphorylation sites. (1989) (68)
Preservation of myocardial beta-adrenergic receptor signaling delays the development of heart failure after myocardial infarction. (2000) (67)
Translocation and uncoupling of the beta-adrenergic receptor in rat lung after catecholamine promoted desensitization in vivo. (1984) (67)
Ligand-induced overexpression of a constitutively active beta2-adrenergic receptor: pharmacological creation of a phenotype in transgenic mice. (1997) (67)
Differences between agonist and antagonist binding following beta-adrenergic receptor desensitization. (1978) (67)
Mammalian alpha 1-adrenergic receptor. Purification and characterization of the native receptor ligand binding subunit. (1986) (66)
The β-adrenergic receptor (1976) (66)
Thyroid hormone modulation of agonist--beta-adrenergic receptor interactions in the rat heart. (1981) (66)
Genomic organization of adrenergic and serotonin receptors in the mouse: linkage mapping of sequence-related genes provides a method for examining mammalian chromosome evolution. (1991) (66)
5-HT1A and histamine H1 receptors in HeLa cells stimulate phosphoinositide hydrolysis and phosphate uptake via distinct G protein pools. (1991) (65)
G Protein-coupled Receptor Kinase 5 Regulates β1-Adrenergic Receptor Association with PSD-95* (2002) (64)
β-Arrestin-1 Competitively Inhibits Insulin-Induced Ubiquitination and Degradation of Insulin Receptor Substrate 1 (2004) (64)
Photoaffinity labelling of mammalian beta-adrenergic receptors: metal-dependent proteolysis explains apparent heterogeneity. (1983) (64)
Seven transmembrane receptors: a brief personal retrospective. (2007) (64)
Activation-dependent conformational changes in {beta}-arrestin 2. (2004) (64)
G protein-coupled receptor kinase 5 regulates airway responses induced by muscarinic receptor activation. (2004) (63)
The cardiac beta-adrenergic receptor. Structural similarities of beta 1 and beta 2 receptor subtypes demonstrated by photoaffinity labeling. (1983) (63)
Transgenic mice with cardiac overexpression of alpha1B-adrenergic receptors. In vivo alpha1-adrenergic receptor-mediated regulation of beta-adrenergic signaling. (1997) (63)
Angiotensin II–Stimulated Signaling Through G Proteins and β-Arrestin (2005) (63)
A fraction of the ventricular myocardium that has the specificity of the cardiac beta-adrenergic receptor. (1971) (62)
[3H]WB4101--caution about its role as an alpha-adrenergic subtype selective radioligand. (1980) (62)
Photoaffinity labeling of mammalian alpha 1-adrenergic receptors. Identification of the ligand binding subunit with a high affinity radioiodinated probe. (1984) (62)
The Impact of Aging on Adrenergic Receptor Function: Clinical and Biochemical Aspects (1985) (62)
Pharmacological blockade of a β2AR-β-arrestin-1 signaling cascade prevents the accumulation of DNA damage in a behavioral stress model (2013) (62)
Antibodies to the beta-adrenergic receptor: attenuation of catecholamine-sensitive adenylate cyclase and demonstration of postsynaptic receptor localization in brain. (1983) (62)
G Protein-coupled Receptor Kinases Phosphorylate LRP6 in the Wnt Pathway* (2009) (61)
[3H]Dihydroergocryptine binding in rat brain (1977) (61)
Structure and regulation of G protein-coupled receptors: the beta 2-adrenergic receptor as a model. (1991) (61)
Direct demonstration of impaired functionality of a purified desensitized beta-adrenergic receptor in a reconstituted system. (1984) (59)
β-Arrestin2 mediates the initiation and progression of myeloid leukemia (2012) (59)
beta-arrestin1 interacts with the catalytic domain of the tyrosine kinase c-SRC. Role of beta-arrestin1-dependent targeting of c-SRC in receptor endocytosis. (2000) (59)
beta 1-adrenergic receptor association with PSD-95. Inhibition of receptor internalization and facilitation of beta 1-adrenergic receptor interaction with N-methyl-D-aspartate receptors. (2000) (59)
alpha-Adrenergic receptors in rat parotid cells. I. Correlation of [3H]dihydroergocryptine binding and catecholamine-stimulated potassium efflux. (1977) (59)
125I-labeled p-azidobenzylcarazolol, a photoaffinity label for the beta-adrenergic receptor. Characterization of the ligand and photoaffinity labeling of beta 1- and beta 2-adrenergic receptors. (1982) (58)
Compartmentation of Cyclic Nucleotide Signaling in the Heart: The Role of Cyclic Nucleotide Phosphodiesterases (2012) (58)
Adenovirus-mediated gene transfer of the β2-adrenergic receptor to donor hearts enhances cardiac function (1999) (58)
Level of &bgr;-Adrenergic Receptor Kinase 1 Inhibition Determines Degree of Cardiac Dysfunction After Chronic Pressure Overload–Induced Heart Failure (2005) (58)
Discovery of β2 Adrenergic Receptor Ligands Using Biosensor Fragment Screening of Tagged Wild-Type Receptor (2013) (58)
Altered airway and cardiac responses in mice lacking G protein-coupled receptor kinase 3. (1999) (57)
Functional differences in the beta gamma complexes of transducin and the inhibitory guanine nucleotide regulatory protein. (1987) (57)
Regulation of myocardial βARK1 expression in catecholamine-induced cardiac hypertrophy in transgenic mice overexpressing α1B-adrenergic receptors (2001) (57)
Identification of adenylate cyclase-coupled beta-adrenergic receptors with radiolabeled beta-adrenergic antagonists. (1975) (57)
G Protein–Coupled Receptor Kinase Mediates Desensitization of Norepinephrine-Induced Ca2+ Channel Inhibition (1996) (56)
Synergistic regulation of beta2-adrenergic receptor sequestration: intracellular complement of beta-adrenergic receptor kinase and beta-arrestin determine kinetics of internalization. (1997) (56)
Conformationally Selective RNA Aptamers Allosterically Modulate the β2-Adrenoceptor (2016) (56)
Regulation of G protein-coupled Receptor Kinase 5 (GRK5) by Actin* (1998) (55)
Hormonal inhibition of adenylate cyclase. alpha 2 Adrenergic receptors promote release of [3H]guanylylimidodiphosphate from platelet membranes. (1982) (54)
Allosteric Modulation of β-Arrestin-biased Angiotensin II Type 1 Receptor Signaling by Membrane Stretch* (2014) (54)
Mechanisms of hormone receptor-effector coupling: the beta-adrenergic receptor and adenylate cyclase. (1982) (54)
Ex vivo adenovirus-mediated gene transfer to the adult rat heart. (1998) (54)
Cardiac adrenergic receptors. (1984) (54)
Characterization of alpha 2-adrenergic receptor subtype-specific antibodies. (1993) (53)
Synthetic peptides of the hamster beta 2-adrenoceptor as substrates and inhibitors of the beta-adrenoceptor kinase. (1990) (53)
Catecholamine-induced desensitization of turkey erythrocyte adenylate cyclase. Structural alterations in the beta-adrenergic receptor revealed by photoaffinity labeling. (1982) (52)
Mechanism of guanine nucleotide regulatory protein-mediated inhibition of adenylate cyclase. Studies with isolated subunits of transducin in a reconstituted system. (1986) (52)
Anomalous equilibrium binding properties of high-affinity racemic radioligands. (1981) (52)
G(o)-protein alpha-subunits activate mitogen-activated protein kinase via a novel protein kinase C-dependent mechanism. (1996) (51)
Restoration of b-adrenergic signaling in failing cardiac ventricular myocytes via adenoviral-mediated gene transfer (1997) (51)
G Protein-coupled Receptor Kinase 5 in Cultured Vascular Smooth Muscle Cells and Rat Aorta (1997) (51)
Arrestins come of age: a personal historical perspective. (2013) (51)
Beta-Adrenergic receptors of human lymphocytes are unaltered by hyperthyroidism. (1979) (51)
Parallel modulation of catecholamine activation of adenylate cyclase and formation of the high-affinity agonist.receptor complex in turkey erythrocyte membranes by temperature and cis-vaccenic acid. (1980) (50)
β-Arrestin Scaffolding of Phosphatidylinositol 4-Phosphate 5-Kinase Iα Promotes Agonist-stimulated Sequestration of the β2-Adrenergic Receptor* (2008) (50)
Myocardial beta-adrenergic receptors from adrenalectomized rats: impaired formation of high-affinity agonist-receptor complexes. (1981) (50)
The beta-adrenergic receptor: rapid purification and covalent labeling by photoaffinity crosslinking. (1982) (50)
Functional integrity of desensitized beta-adrenergic receptors. (1983) (50)
Mechanisms of Ligand-Induced Desensitization of Beta-Adrenergic Receptors (1991) (49)
Subtype specificity of alpha-adrenergic receptors in rat heart. (1981) (49)
Adrenergic receptors: recent insights into their mechanism of activation and desensitization. (1993) (49)
Regulation of beta adrenergic receptors in isolated frog erythrocyte plasma membranes. (1977) (48)
Adrenergic receptors. (1980) (48)
Genetic regulation of beta-adrenergic receptors. (1989) (48)
Association of sequestered beta-adrenergic receptors with the plasma membrane: a novel mechanism for receptor down regulation. (1984) (48)
Characteristics of 5'-guanylyl imidodiphosphate-activated adenylate cyclase. (1975) (48)
G beta gamma subunits mediate mitogen-activated protein kinase activation by the tyrosine kinase insulin-like growth factor 1 receptor. (1995) (48)
Beta-Adrenergic Receptors (1991) (48)
Sortase ligation enables homogeneous GPCR phosphorylation to reveal diversity in β-arrestin coupling (2018) (48)
Evidence that a beta-adrenergic receptor-associated guanine nucleotide regulatory protein conveys guanosine 5'-O-(3-thiotriphosphate)- dependent adenylate cyclase activity. (1981) (48)
Regulation of the β2‐adrenergic receptor and its mRNA in the rat ventral prostate by testosterone (1988) (47)
Mechanism of β2AR regulation by an intracellular positive allosteric modulator (2019) (47)
GIPC interacts with the beta1-adrenergic receptor and regulates beta1-adrenergic receptor-mediated ERK activation. (2003) (47)
Two kinases mediate agonist-dependent phosphorylation and desensitization of the beta 2-adrenergic receptor. (1990) (47)
G Protein–Coupled Receptors and Receptor Kinases: From Molecular Biology to Potential Therapeutic Applications (1996) (47)
The human placenta--a rich source of beta-adrenergic receptors: characterization of the receptors in particulate and solubilized preparations. (1980) (46)
Coupling of the expressed alpha 1B-adrenergic receptor to the phospholipase C pathway in Xenopus oocytes. The role of Go. (1993) (46)
Localization of the fourth membrane spanning domain as a ligand binding site in the human platelet alpha 2-adrenergic receptor. (1989) (45)
Epidermal Growth Factor (EGF) Receptor-dependent ERK Activation by G Protein-coupled Receptors A CO-CULTURE SYSTEM FOR IDENTIFYING INTERMEDIATES UPSTREAM AND DOWNSTREAM OF HEPARIN-BINDING EGF SHEDDING* (2001) (45)
β-Arrestin2 Couples Metabotropic Glutamate Receptor 5 to Neuronal Protein Synthesis and Is a Potential Target to Treat Fragile X. (2017) (45)
Photoaffinity labeling of the beta-adrenergic receptor. (1981) (45)
Regulation of Adrenergic Receptors (1981) (45)
Cloning and sequence analysis of the human beta 1-adrenergic receptor 5'-flanking promoter region. (1993) (45)
Hypothyroidism modulates beta adrenergic receptor adenylate cyclase interactions in rat reticulocytes. (1981) (45)
Biased G Protein-Coupled Receptor Signaling: Changing the Paradigm of Drug Discovery. (2018) (45)
Preferential uncoupling by manganese of alpha adrenergic receptor mediated inhibition of adenylate cyclase in human platelets. (1981) (45)
Clinical physiology of adrenergic receptor regulation. (1982) (44)
α‐Actinin is a potent regulator of G protein‐coupled receptor kinase activity and substrate specificity in vitro (2000) (44)
Small-Molecule Positive Allosteric Modulators of the β2-Adrenoceptor Isolated from DNA-Encoded Libraries (2018) (44)
Cardiac muscarinic potassium channel activity is attenuated by inhibitors of G beta gamma. (1995) (44)
Role of phosphorylation in desensitization of the beta-adrenoceptor. (1990) (44)
Hepatic alpha-adrenergic receptors. Identification and subcellular localization using [3H]dihydroergocryptine. (1978) (43)
The human 5-HT1A receptor expressed in HeLa cells stimulates sodium-dependent phosphate uptake via protein kinase C. (1989) (43)
Regulation of beta-adrenergic receptors by steroid hormones. (1984) (43)
An approach to the study of G-protein-coupled receptor kinases: an in vitro-purified membrane assay reveals differential receptor specificity and regulation by G beta gamma subunits. (1994) (42)
Transgenic manipulation of myocardial G protein-coupled receptors and receptor kinases. (1996) (42)
G-protein-coupled receptor kinase specificity for beta-arrestin recruitment to the beta2-adrenergic receptor revealed by fluorescence resonance energy transfer. (2006) (41)
Agonist-specific alterations in receptor binding affinity associated with solubilization of turkey erythrocyte membrane beta adrenergic receptors. (1978) (41)
Phosducin, Potential Role in Modulation of Olfactory Signaling* (1997) (40)
Polymorphonuclear leukocyte function in psoriasis: chemotaxis, chemokinesis, beta-adrenergic receptors, and proteolytic enzymes of polymorphonuclear leukocytes in the peripheral blood from psoriatic patients. (1983) (40)
Molecular and regulatory properties of adrenergic receptors. (1987) (40)
Molecular mechanisms of activation and desensitization of adenylate cyclase coupled beta-adrenergic receptors. (1978) (40)
Functional modification of the guanine nucleotide regulatory protein after desensitization of turkey erythrocytes by catecholamines. (1983) (40)
Mammalian beta-adrenergic receptors. Structural differences in beta 1 and beta 2 subtypes revealed by peptide maps. (1983) (40)
Correlation of beta-adrenergic receptor-stimulated [3H]GDP release and adenylate cyclase activation. Differences between frog and turkey erythrocyte membranes. (1981) (39)
alpha-Adrenergic receptors in human adipocyte membranes: direct determination by [3H]yohimbine binding. (1981) (39)
Different sedimentation properties of agonist- and antagonist-labelled platelet alpha 2 adrenergic receptors. (1981) (39)
Level of beta-adrenergic receptor kinase 1 inhibition determines degree of cardiac dysfunction after chronic pressure overload-induced heart failure. (2005) (39)
In vivo inhibition of elevated myocardial beta-adrenergic receptor kinase activity in hybrid transgenic mice restores normal beta-adrenergic signaling and function. (1999) (38)
Activation and desensitization of beta-adrenergic receptor-coupled GTPase and adenylate cyclase of frog and turkey erythrocyte membranes. (1980) (38)
Adrenergic receptors: biochemistry, regulation, molecular mechanism, and clinical implications. (1982) (38)
Phorbol ester effects on alpha 1-adrenoceptor binding and phosphatidylinositol metabolism in cultured vascular smooth muscle cells. (1985) (38)
Hormone-sensitive adenylate cyclase. Delineation of a trypsin-sensitive site in the pathway of receptor-mediated inhibition. (1982) (38)
Catecholamine-induced desensitization in turkey erythrocytes: cAMP mediated impairment of high affinity agonist binding without alteration in receptor number. (1981) (38)
Reconstitution of beta-adrenergic receptors in lipid vesicles: affinity chromatography-purified receptors confer catecholamine responsiveness on a heterologous adenylate cyclase system. (1983) (38)
Phosphorylation and Desensitization of the Human -Adrenergic Receptor (1995) (37)
Identification of NSF as a beta-arrestin1-binding protein. Implications for beta2-adrenergic receptor regulation. (1999) (37)
Determination of subtype selectivity of alpha-adrenergic antagonists: comparison of selective and nonselective radioligands. (1981) (37)
Alternative explanation for the apparent "two-step" binding kinetics of high-affinity racemic antagonist radioligands. (1981) (36)
G beta gamma interactions with PH domains and Ras-MAPK signaling pathways. (1995) (36)
Ectopic beta-adrenergic receptor binding sites. possible molecular basis of aberrant catecholamine responsiveness of an adrenocortical tumor adenylate cyclase. (1977) (36)
Identification of O-Adrenergic Receptors in Human Lymphocytes by ( ) [ 3 H ] Alprenolol Binding (36)
Catecholamine stimulated myocardial adenylate cyclase: effects of phospholipase digestion and the role of membrane lipids. (1975) (36)
Granulocyte chemotaxis and disease expression are differentially regulated by GRK subtype in an acute inflammatory arthritis model (K/BxN). (2008) (36)
G protein–coupled receptor kinases (GRKs) orchestrate biased agonism at the β2-adrenergic receptor (2018) (35)
International Workshop at the Nobel Forum, Karolinska Institutet on G protein-coupled receptors: finding the words to describe monomers, oligomers, and their molecular mechanisms and defining their meaning. Can a consensus be reached? (2010) (35)
Alpha 2-adrenergic agonists stimulate DNA synthesis in Chinese hamster lung fibroblasts transfected with a human alpha 2-adrenergic receptor gene. (1990) (35)
Binding of catecholamines to receptors in cultured myocardial cells. (1973) (34)
Plasma membrane receptors. (1983) (34)
Molecular pharmacology of alpha adrenergic receptors: utilization of [3H]dihydroergocryptine binding in the study of pharmacological receptor alterations. (1977) (33)
Transducin and the inhibitory nucleotide regulatory protein inhibit the stimulatory nucleotide regulatory protein mediated stimulation of adenylate cyclase in phospholipid vesicle systems. (1985) (33)
Effects of local anesthetics on guanyl nucleotide modulation of the catecholamine-sensitive adenylate cyclase system and on beta-adrenergic receptors. (1980) (33)
Adrenergic receptors: molecular mechanisms of clinically relevant regulation. (1985) (33)
The new biology of drug receptors. (1989) (33)
Alpha 2 adrenergic receptors are located prejunctionally in the Auerbach's plexus of the guinea pig small intestine: direct demonstration by radioligand binding. (1982) (33)
Myocardial G protein-coupled receptor kinases: implications for heart failure therapy. (1999) (33)
Mutational analysis of the pleckstrin homology domain of the beta-adrenergic receptor kinase. Differential effects on G beta gamma and phosphatidylinositol 4,5-bisphosphate binding. (1995) (32)
β-Adrenergic receptors and rhodopsin: shedding new light on an old subject (1986) (32)
G protein signaling and vein graft intimal hyperplasia: reduction of intimal hyperplasia in vein grafts by a Gbetagamma inhibitor suggests a major role of G protein signaling in lesion development. (1998) (32)
Norepinephrine: dissociation of -receptor binding from adenylate cyclase activation in solubilized myocardium. (1972) (31)
Potent beta-adrenergic antagonist possessing chemically reactive group. (1980) (31)
Erratum: Constitutively active mutants of the α2-adrenergic receptor (Journal of Biological Chemistry (1993) 268 (16483-16487)) (1994) (31)
Inhibition of Spontaneous β2-Adrenergic Activation Rescues β1-Adrenergic Contractile Response in Cardiomyocytes Overexpressing β2-Adrenoceptor* (2000) (31)
Molecular biology of adrenergic receptors. (1988) (30)
Beta 2-adrenergic receptor stimulated, G protein-coupled receptor kinase 2 mediated, phosphorylation of ribosomal protein P2. (2002) (30)
A crystal clear view of the β2-adrenergic receptor (2008) (30)
Light-dependent phosphorylation of rhodopsin by beta-adrenergic receptor kinase. (1986) (30)
Receptor regulation: beta-arrestin moves up a notch. (2005) (30)
RADIOLIGAND BINDING STUDIES OF ADRENERGIC RECEPTORS (1980) (30)
G proteins in medicine. (1995) (30)
Isolated hormone receptors: physiologic and clinical implications. (1973) (30)
cDNA cloning and chromosomal localization of the human α‐adrenergic receptor kinase (1991) (30)
Beta-adrenergic receptor-coupled adenylate cyclase. Biochemical mechanisms of regulation. (1987) (30)
Dephosphorylation of the beta 2-adrenergic receptor and rhodopsin by latent phosphatase 2. (1988) (29)
Enhanced vasorelaxation by overexpression of beta 2-adrenergic receptors in large arteries. (1998) (29)
Molecular mechanisms of beta-adrenergic receptor desensitization. (1980) (29)
New directions in adrenergic receptor research part II (1980) (29)
Bbeta-adrenergic receptor kinase-1 levels in catecholamine-induced myocardial hypertrophy: regulation by beta- but not alpha1-adrenergic stimulation. (1999) (29)
Identification of the subunit-binding site of alpha 2-adrenergic receptors using [3H]phenoxybenzamine. (1984) (29)
Purification and characterization of the beta-adrenergic receptor kinase. (1987) (29)
A Brief History of G‐Protein Coupled Receptors (Nobel Lecture) (2013) (29)
Variations on a theme (1991) (29)
Desensitization of beta-adrenergic stimulated adenylate cyclase in turkey erythrocytes. (1979) (28)
Transgenic manipulation of beta-adrenergic receptor kinase modifies cardiac myocyte contraction to norepinephrine. (1997) (28)
Regulation of adenylate cyclase coupled beta-adrenergic receptors. (1976) (28)
Homologous desensitization of the beta-adrenergic receptor. Functional integrity of the desensitized receptor from mammalian lung. (1985) (28)
Molecular biology of alpha-adrenergic receptors: implications for receptor classification and for structure-function relationships. (1991) (28)
Production of adrenergic receptors in yeast. (1996) (28)
Adenovirus-mediated genetic manipulation of the myocardial beta-adrenergic signaling system in transplanted hearts. (2000) (28)
Identification of the ligand-binding subunit of the human 5-hydroxytryptamine1A receptor with N-(p-azido-m-[125I] iodophenethyl)spiperone, a high affinity radioiodinated photoaffinity probe. (1989) (27)
β-arrestin 1 regulates β2-adrenergic receptor-mediated skeletal muscle hypertrophy and contractility (2018) (27)
Crystallizing Thinking about the β2-Adrenergic Receptor (2008) (27)
Human β 1- and β 2-adrenergic receptors: structurally and functionally related receptors derived from distinct genes (1988) (27)
Homologous desensitization of beta-adrenergic receptor coupled adenylate cyclase. Resensitization by polyethylene glycol treatment. (1985) (27)
Mechanisms involved in adrenergic receptor desensitization. (1990) (27)
(3H)-Propranolol binding sites in myocardial membranes: nonidentity with beta adrenergic receptors. (1974) (27)
Altered airway and cardiac responses in mice lacking G protein-coupled receptor kinase 3. (1999) (27)
Regulation of myocardial betaARK1 expression in catecholamine-induced cardiac hypertrophy in transgenic mice overexpressing alpha1B-adrenergic receptors. (2001) (27)
[3H]Dihydroergocryptine binding to alpha adrenergic receptors in canine aortic membranes. (1978) (26)
Mechanism of beta2AR regulation by an intracellular positive allosteric modulator. (2019) (26)
β2‐Adrenergic receptor overexpression in the developing mouse heart: evidence for targeted modulation of ion channels (1999) (26)
Agonist interactions with alpha-adrenergic receptors. (1982) (26)
The subunit story thickens (1992) (25)
An assay for alpha-adrenergic receptor subtypes using [3H]dihydroergocryptine. (1980) (24)
Identification of Adenylate Cyclase-coupled fi -Adrenergic Receptors in Frog Erythrocytes with (-) -( 311) Alprenolol" (1975) (24)
Phosphorylation of the beta-adrenergic receptor accompanies catecholamine-induced desensitization of turkey erythrocyte adenylate cyclase. (1983) (24)
Myocardial β-adrenergic receptor signaling in vivo: insights from transgenic mice (1996) (23)
Phosphorylation of the beta-adrenergic receptor in intact cells: relationship to heterologous and homologous mechanisms of adenylate cyclase desensitization. (1987) (23)
Properties of the beta 1- and beta 2-adrenergic receptor subtypes revealed by molecular cloning. (1989) (23)
Costimulation of Adenylyl Cyclase and Phospholipase C by a Mutantα 1B-Adrenergic Receptor Transgene Promotes Malignant Transformation of Thyroid Follicular Cells1. (1997) (23)
Temperature immutability of adenyl cyclase-coupled β adrenergic recptors (1974) (23)
Guanine nucleotides and alpha 1 adrenergic receptors in the heart. (1983) (23)
A desensitized state of the beta adrenergic receptor not associated with high-affinity agonist occupancy. (1978) (22)
β-Arrestin Regulation of Myosin Light Chain Phosphorylation Promotes AT1aR-mediated Cell Contraction and Migration (2013) (22)
The mammalian beta-adrenergic receptor: structural and functional characterization of the carbohydrate moiety. (1987) (22)
(3H)norepinephrine binding: unrelated to catechol-O-methyl transferase. (1974) (22)
Beta-Adrenergic receptors: solubilization of (-)(3H)alprenolol binding sites from frog erythrocyte membranes. (1976) (22)
Detergent- and phospholipid-based reconstitution systems have differential effects on constitutive activity of G-protein–coupled receptors (2019) (22)
Targeting G bg signaling in arterial vascular smooth muscle proliferation: A novel strategy to limit restenosis (1999) (22)
Cell-free desensitization of catecholamine-sensitive adenylate cyclase. Agonist- and cAMP-promoted alterations in turkey erythrocyte beta-adrenergic receptors. (1984) (21)
Affinity chromatography of human platelet α2-adrenergic receptors (1982) (21)
β-Adrenoreceptors determine affinity but not intrinsic activity of adenylate cyclase stimulants (1979) (21)
Beta-adrenergic receptors: recognition and regulation. (1976) (21)
Myocardial guanylate cyclase: properties of the enzyme and effects of cholinergic agonists in vitro. (1975) (21)
Synthetic nanobodies as angiotensin receptor blockers (2020) (21)
Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by GBy activation of p 2 lras (2005) (21)
Surface interaction of [3H]norepinephrine with cultured chick embryo myocardial cells (1974) (21)
G-protein-coupled receptors. Turned on to ill effect. (1993) (21)
Stereospecific (3H)(minus)-alprenolol binding sites, beta-adrenergic receptors and adenylate cyclase. (1974) (20)
Substitution of an extracellular cysteine in the beta 2-adrenergic receptor enhances agonist-promoted phosphorylation and receptor desensitization. (1989) (20)
Purification, crystallization and preliminary X-ray diffraction studies of a complex between G protein-coupled receptor kinase 2 and Gβ1γ2 (2003) (20)
Activation, desensitization, and recycling of frog erythrocyte beta-adrenergic receptors. Differential perturbation by in situ trypsinization. (1984) (20)
Endogenous proteinases modulate the function of the beta-adrenergic receptor-adenylate cyclase system. (1984) (20)
Impaired formation of beta-adrenergic receptor-nucleotide regulatory protein complexes in pseudohypoparathyroidism. (1984) (20)
Marked enhancement in myocardial function resulting from overexpression of a human beta-adrenergic receptor gene. (1995) (19)
Adrenergic receptor homologies in vertebrate and invertebrate species examined by DNA hybridization. (1989) (19)
Differential effects of cholera toxin on guanine nucleotide regulation of beta-adrenergic agonist high affinity binding and adenylate cyclase activation in frog erythrocyte membranes. (1981) (19)
Covalent labeling of the beta-adrenergic ligand-binding site with para-(bromoacetamidyl)benzylcarazolol. A highly potent beta-adrenergic affinity label. (1985) (19)
Multiple effects of guanine nucleotides on human platelet adenylated cyclase. (1979) (19)
Inhibition of βARK1 restores impaired biochemical β-adrenergic receptor responsiveness but does not rescue CREBA133 induced cardiomyopathy (2002) (19)
Identification of alpha-adrenergic receptors in human platelets by [3H]dihydroergocryptine binding. (1978) (19)
β-Adrenergic receptor binding: synaptic localization in rat brain (1976) (19)
Solubilization of rat liver alpha 1-adrenergic receptors. Agonist specific alteration in receptor binding affinity. (1983) (19)
SnapShot: β-Arrestin Functions (2020) (19)
Commentary. Molecular pharmacology of beta-adrenergic receptors--a status report. (1974) (19)
Development of an affinity ligand for purification of alpha 2-adrenoceptors from human platelet membranes. (1984) (18)
11 – The Effects of Thyroid Hormone on Adrenergic Receptors (1983) (18)
Structure and biological activity of (-)-[3H]dihydroalprenolol, a radioligand for studies of beta-adrenergic receptors. (1977) (18)
Targeting G protein-coupled receptor kinases to their receptor substrates (1997) (18)
Preservation of myocardial b-adrenergic receptor signaling delays the development of heart failure after myocardial infarction (2000) (18)
Interactions of agonists with platelet alpha 2-adrenergic receptors. (1982) (18)
Separation of solubilized alpha and beta adrenergic receptors by affinity chromatography. (1979) (18)
Immunoaffinity purification of epitope-tagged human beta 2-adrenergic receptor to homogeneity. (1995) (17)
The β-arrestin-biased β-adrenergic receptor blocker carvedilol enhances skeletal muscle contractility (2020) (17)
GTPases in Biology II (1993) (17)
Guanosine triphosphate binding sites in solubilized myocardium. Relation to adenylate cyclase activity. (1975) (17)
The b 2-adrenergic receptor interactswith the Na + / H +-exchanger regulatory factor tocontrol Na + / H + exchange (16)
The role of β-arrestin2-dependent signaling in thoracic aortic aneurysm formation in a murine model of Marfan syndrome (2015) (16)
Functional analysis of myocardial performance in murine hearts overexpressing the human beta 2-adrenergic receptor. (1997) (16)
β-Arrestin–Biased Angiotensin II Receptor Agonists for COVID-19 (2020) (16)
Photoaffinity labeling of turkey erythrocyte beta-adrenergic receptors: degradation of the Mr = 49,000 protein explains apparent heterogeneity. (1984) (16)
Direct studies of β-adrenergic receptors in intact frog erythrocytes (1976) (16)
Myocardial beta-adrenergic receptor signaling in vivo: insights from transgenic mice. (1996) (16)
Overexpression of pp60c-src is associated with altered regulation of adenylyl cyclase. (1992) (16)
Desensitization of the Turkey Erythrocyte &Adrenergic Receptor in a Cell-free System (1985) (16)
Catecholamine stimulated myocardial adenylate cyclase: effects of nucleotides. (1975) (16)
Smoking, Catecholamines, and the Heart (1976) (15)
GPCR signaling: conformational activation of arrestins (2018) (15)
Arrestins as Signaling Molecules Involved in Apoptotic Pathways: A Real Eye Opener (2001) (15)
Effect of thyroid status on α- and β-catecholamine responsiveness of hamster adipocytes (1981) (15)
DiscussionNew directions in adrenergic receptor research: Part I (1980) (15)
Effect of pertussis toxin on α2‐adrenoceptors: decreased formation of the high‐affinity state for agonists (1984) (15)
Comparison of specificity of agonist and antagonist radioligand binding to β adrenergic receptors (1977) (15)
Myocardial overexpression of adrenergic receptors and receptor kinases. (1998) (15)
Synthesis of iodine-125 labeled (+/-)-15-(4-azidobenzyl)carazolol: a potent beta-adrenergic photoaffinity probe. (1983) (14)
Letter: Insulin activity: the solid matrix. (1973) (14)
Costimulation of adenylyl cyclase and phospholipase C by a mutant alpha 1B-adrenergic receptor transgene promotes malignant transformation of thyroid follicular cells. (1997) (14)
Purification, crystallization and preliminary X-ray diffraction studies of a complex between G protein-coupled receptor kinase 2 and Gbeta1gamma2. (2003) (14)
Identification of the Subunit Structure of Rat Pineal Adrenergic Receptors by Photoaffinity Labeling (1986) (14)
Selectivity in Beta‐Adrenergic Responses: Clinical Implications (1974) (14)
The beta-adrenergic receptor and adenylate cyclase. (1976) (14)
Identification and Regulation of β-Adrenergic Receptors (1978) (14)
The Application of the Cognitive Behavioral Model to Two Older Stressor Groups (1990) (14)
Use of cell fusion techniques to probe the mechanism of catecholamine-induced desensitization of adenylate cyclase in frog erythrocytes. (1980) (14)
Photoaffinity labeling of β-adrenergic receptors in mammalian tissues (1984) (14)
Regulation of G protein-coupled receptors by agonist-dependent phosphorylation. (1990) (13)
Differential regulation of the alpha 2-adrenergic receptor by Na+ and guanine nucleotides. (1980) (13)
Agonist-dependent phosphorylation of the alpha 2-adrenergic receptor by the beta-adrenergic receptor kinase. (1987) (13)
Adenylate-Cyclase-Coupled β- Adrenergic Receptors (1985) (13)
The beta-adrenergic receptor in heart failure. (1983) (13)
Signaling at the endosome: cryo‐EM structure of a GPCR–G protein–beta‐arrestin megacomplex (2021) (13)
Sensitization of frog erythrocyte adenylate cyclase system by tumor-promoting phorbol diesters. (1985) (13)
Gene transfer strategies for augmenting cardiac function. (1997) (13)
Allosteric activation of proto-oncogene kinase Src by GPCR–beta-arrestin complexes (2020) (12)
Cyclic phosphorylation-dephosphorylation of rhodopsin in retina by protein kinase FA (the activator of ATP.Mg-dependent protein phosphatase). (1991) (12)
Cloning of the cDNA and genes for the hamster and human beta 2-adrenergic receptors. (1988) (12)
Chronic guanethidine treatment increases cardiac beta-adrenergic receptors. (1978) (12)
(3H)norepinephrine binding and lipolysis by isolated fat cells. (1974) (12)
Covalent labeling of the cerebral cortex alpha 1-adrenergic receptor with a new high affinity radioiodinated photoaffinity probe. (1983) (12)
Structure and function of the adrenergic receptor family. (1991) (11)
Genetic mapping of the β-arrestin 1 and 2 genes on mouse Chromosomes 7 and 11 respectively (1995) (11)
GPCR-mediated β-arrestin activation deconvoluted with single-molecule precision (2022) (11)
Identification of the endophilins ( SH 3 p 4 y p 8 y p 13 ) as novel binding partners for the b 1-adrenergic receptor (1999) (11)
Chemical modification of α2-adrenoceptors: Possible role for tyrosine in the ligand binding site (1986) (10)
A Phenogenetic Study of the Lozenge Pseudoalleles in Drosophila Melanogaster. I. Effects on the Development of the Tarsal Claws in Homozygotes. (1956) (10)
Molecular pharmacology of adenylate cyclase-coupled alpha- and beta-adrenergic receptors. (1981) (10)
Structure and function of beta-adrenergic receptors: regulation at the molecular level. (1984) (10)
Epidermal Growth Factor (EGF) Receptor-dependent ERK Activation by G Protein-coupled Receptors A CO-CULTURE SYSTEM FOR IDENTIFYING INTERMEDIATES UPSTREAM AND DOWNSTREAM OF (2001) (10)
Functionally active targeting domainofthef-adrenergic receptor kinase: Aninhibitor ofGp'.mediated stimulation oftypeII adenylyl cyclase (1994) (10)
Regulation of adenylate cyclase coupled beta-adrenergic receptors by beta-adrenergic catecholamines. (1976) (10)
Global phosphorylation analysis of β-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR) (Proceedings of the National Academy of Sciences of the United States of America (2010) 107, 34 (15299-15304) doi (2012) (9)
Adrenergic receptors. (1988) (9)
Regulation of β-Adrenergic Receptors by β-Adrenergic Agonists (1978) (9)
Erratum: Identification and sequence of a binding site peptide of the β2-adrenergic receptor (Biochemistry (1988) 27, 6, (1813-1817)) (1988) (9)
β-Arrestin–Biased Allosteric Modulator Potentiates Carvedilol-Stimulated β Adrenergic Receptor Cardioprotection (2021) (9)
A magnificent time with the "magnificent seven" transmembrane spanning receptors. (2003) (9)
Photoaffinity labeling of human platelet and rabbit kidney α2-adrenoceptors with [3H]SKF 102229 (1986) (9)
CHARACTERIZATION AND PURIFICATION OF THE CARDIAC β-ADRENERGIC RECEPTOR (1972) (9)
Photoaffinity cross-linking of a radioiodinated probe, 125I-A55453, into alpha 1-adrenergic receptors. (1984) (8)
Determination of the molecular size of frog and turkey erythrocyte .beta.-adrenergic receptors by radiation inactivation (1984) (8)
Structure and function of the beta 2-adrenergic receptor--homology with rhodopsin. (1987) (8)
Pharmacological activity of nitroxide analogues of dichloroisoproterenol and propranolol. (1976) (8)
Phosphorylation and Desensitization of Human Endothelin (1997) (8)
Enhanced adenylate cyclase activity of turkey erythrocytes following treatment with beta-adrenergic receptor antagonists. (1984) (8)
β-Adrenergic receptor-coupled adenylate cyclase (2008) (8)
Potentiation of beta-adrenergic signaling by gene transfer. (1997) (8)
Human beta 1- and beta 2-adrenergic receptors: structurally and functionally related receptors derived from distinct genes. (1988) (8)
CHAPTER 13 – Structure and Function of Adrenergic Receptors: Models for Understanding G Protein-Coupled Receptors (1990) (7)
Summary of wenner-gren international symposium receptor-receptor interactions among heptaspanning membrane receptors: From structure to function (2007) (7)
Structural, Functional, and Genetic Aspects of Receptors Coupled to G-Proteins (1992) (7)
Level of (cid:1) -Adrenergic Receptor Kinase 1 Inhibition Determines Degree of Cardiac Dysfunction After Chronic Pressure Overload–Induced Heart Failure Heart Failure (2005) (7)
STRUCTURE AND BIOLOGICAL ACTIVITY OF (-)-(3H)-DIHYDROALPRENOLOL, A RADIOLIGAND FOR STUDIES OF β-ADRENERGIC RECEPTORS (1977) (7)
Macromolecular beta-adrenergic antagonists discriminating between receptor and antibody. (1980) (7)
Inhibition of betaARK1 restores impaired biochemical beta-adrenergic receptor responsiveness but does not rescue CREB(A133) induced cardiomyopathy. (2002) (7)
Biochemical characterization of the adrenergic receptors: affinity labeling, purification, and reconstitution studies. (1985) (7)
The beta-adrenergic receptor. (1976) (7)
Receptor regulation: β-arrestin moves up a notch (2005) (7)
Synthetic peptides of the hamster P2-adrenoceptor as substrates and inhibitors of the 3-adrenoceptor kinase (2006) (7)
Activation of adenylate cyclase by beta-adrenergic receptors: investigation of rate limiting steps by simultaneous assay of high affinity agonist binding and GDP release. (1983) (7)
Autophagy Genes Are Essential for Dauer Development and Life-Span Extension in C. elegans (2022) (7)
The β-Adrenergic Receptor: Ligand Binding Studies Illuminate the Mechanism of Receptor-Adenylate Cyclase Coupling (1983) (7)
Heterogeneity of adenylate cyclase-coupled beta-adrenergic receptors. (1975) (7)
Unique Positive Cooperativity Between the β-Arrestin–Biased β-Blocker Carvedilol and a Small Molecule Positive Allosteric Modulator of the β2-Adrenergic Receptor (2021) (7)
Inspiring the next generation of physician-scientists. (2015) (7)
The third beta is not the charm. (1996) (7)
Differential effects of GTP on the coupling of beta-adrenergic receptors to adenylate cyclase from frog and turkey erythrocytes. Application of new methods for the analysis of receptor-effector coupling. (1979) (6)
Regulation of the Adenylate Cyclase Signalling Pathway: Potential Role for the Phosphorylation of the Catalytic Unit by Protein Kinase A and Protein Kinase C (1988) (6)
Rodbell and Gilman win 1994 Nobel Prize for Physiology and Medicine. (1994) (6)
Agonist-induced increase in apparent beta-adrenergic receptor size. (1978) (6)
1 GRK AND β-ARRESTIN MEDIATED DESENSITIZATION OF THE ANGIOTENSIN II TYPE 1 A RECEPTOR ELUCIDATED BY DIACYLGLYCEROL DYNAMICS (2006) (6)
The alpha 1C-adrenergic receptor: a new member in the alpha 1-adrenergic receptor family. (1990) (6)
Arylazide photoaffinity probe for α2-adrenoceptors (1985) (6)
The G protein-coupled receptor phosphatase (2000) (6)
Structure of an endosomal signaling GPCR–G protein–β-arrestin megacomplex (2019) (6)
Molecular mechanisms of beta-adrenergic receptor desensitization. (1987) (6)
The Active Conformation of β-Arrestin1 (2007) (6)
Introduction to Special Section on ?-Arrestins (2007) (6)
Recent molecular analyses of β-adrenergic receptor phosphorylation, sequestration and down regulation (1992) (6)
G Protein Signaling and Vein Graft Intimal Hyperplasia: Reduction of Intimal Hyperplasia in Vein Grafts by a Gbg Inhibitor (1998) (6)
Reconstitution of the β-adrenergic receptor (2005) (6)
Polymeric drugs by direct copolymerization: Polymer of β-adrenergic antagonist alprenolol and its binding to receptors and antibodies (1981) (6)
The beta-adrenergic receptor kinase: role in homologous desensitization in S49 lymphoma cells. (1988) (6)
Antibodies raised against purified β-adrenergic receptors specifically bind β-adrenergic ligands (1979) (6)
CHAPTER 2 – Regulation of Adenylate Cyclase by Adrenergic Receptors (1982) (6)
Regulation of mitogen-activated protein kinase pathways by catecholamine receptors. (1998) (6)
Subtype Specificity of α‐Adrenergic Receptors in Rat Heart (1981) (6)
(cid:1) -Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation (2020) (5)
Beta-adrenergic receptors: regulatory role of agonists. (1978) (5)
The spirit of science. Presidential address to the American Society for Clinical Investigation, Washington, DC, 30 April 1988. (1988) (5)
Affinity chromatography of human platelet alpha 2-adrenergic receptors. (1982) (5)
Dihydroergocryptine binding and alpha-adrenoreceptors in smooth muscle. (1980) (5)
Inhibition of spontaneous beta 2-adrenergic activation rescues beta 1-adrenergic contractile response in cardiomyocytes overexpressing beta 2-adrenoceptor. (2000) (5)
Dopaminergic Receptors in the Anterior Pituitary Gland (2011) (5)
Effect of thyroid status on alpha- and beta-catecholamine responsiveness of hamster adipocytes. (1981) (5)
Regulation of b 2 -Adrenergic Receptor Function by Conformationally Selective Single-Domain Intrabodies s (2014) (5)
Methodological Approach to Radioligand Binding Studies of Adrenergic Receptors (1979) (5)
Temperature immutability of adenyl cyclase-coupled beta adrenergic receptors. (1974) (5)
[89] Adrenergic receptors and binding proteins (1974) (5)
Erratum: Localization of the fourth membrane spanning domain as a ligand binding site in the human platelet α2-adrenergic receptor (Biochemistry (1989) 28, 9, (4125-4130)) (1989) (5)
Biochemical characterization of the BETA-adrenergic receptor of the frog erythrocyte (1979) (5)
Physiological Receptors as Physicochemical Entities (1973) (5)
Translating science to medicine: The case for physician-scientists (2022) (5)
INHIBITION OF RECEPTOR INTERNALIZATION AND FACILITATION OF b1-ADRENERGIC RECEPTOR INTERACTION WITH N-METHYL-D-ASPARTATE RECEPTORS* (2000) (4)
DESENSITIZATION OF ß-ADRENERGIC RECEPTORS BY ß-ADRENERGIC AGONISTS (1978) (4)
β-Arrestin2 mediates progression of murine primary myelofibrosis. (2017) (4)
GENETIC REGULATION OF {3-ADRENERGIC RECEPTORS (1989) (4)
G-protein-coupled receptor genes as protooncogenes : Constitutively activating mutation of the a 1 B-adrenergic receptor enhances mitogenesis and tumorigenicity ( catecholam / tranformation / atherogenesis ) (4)
Desensitization of f3-adrenergic receptors by f3-adrenergic agonists in a cell-free system: Resensitization by guanosine 5'-(f3,^y-imino)triphosphate and other purine nucleotides (4)
Isolated beta-adrenergic binding sites: a potential assay vehicle for catecholamines. (1973) (4)
b 1 -Adrenergic Receptor Association with PSD-95 INHIBITION OF RECEPTOR INTERNALIZATION AND FACILITATION OF b 1 -ADRENERGIC RECEPTOR INTERACTION WITH N -METHYL- D -ASPARTATE RECEPTORS* (2000) (4)
Insulin Activity: The Solid Matrix (1973) (3)
Biological activity of agarose-immobilized catecholamines. (1976) (3)
Membrane Receptors, Cyclic Nucleotides,and Transport (1978) (3)
BETA-ARRESTINS REGULATE SIGNALING BY BONE MORPHOGENETIC PROTEIN TYPE II RECEPTOR IN PULMONARY ARTERIAL HYPERTENSION (2011) (3)
The annual ASCI meeting: does nostalgia have a future? (2008) (3)
Allosteric activation of proto-oncogene kinase Src by GPCR-beta-arrestin complexes. (2020) (3)
Regulation of insulin receptors in frog erythrocytes by insulin and concanavalin A. Evidence for discrete classes of insulin binding sites. (1982) (3)
Inhibitory effect of ristocetin and factor VIII/von Willebrand factor protein on human platelet adenylate cyclase activity. (1983) (3)
Ciba-Geigy award for outstanding research. Regulation of adrenergic receptor function by phosphorylation. (1986) (3)
A tale of two callings. (2011) (3)
The Role of Receptor Kinases and Arrestin-Like Proteins in G-Protein-Linked Receptor Desensitization (1993) (3)
Introduction to the series on novel aspects of cardiovascular G-protein-coupled receptor signaling. (2011) (3)
A Serendipitous Scientist. (2018) (3)
Influence of experimental myocardial ischemia on beta adrenergic receptors*1 (1979) (3)
Agonist versus antagonist binding to a-adrenergic receptors (al and (3)
The b2-Adrenergic Receptor Mediates Extracellular Signal-regulated Kinase Activation via Assembly of a Multi-receptor Complex with the Epidermal Growth Factor Receptor* (2000) (3)
Membrane-Bound Hormone Receptors (1976) (3)
Postictal Modulation of Breathing by the Central Amygdala (CeA) Can Induce Sudden Unexpected Death in Epilepsy (SUDEP). (2020) (3)
Alpha-Adrenergic Receptors in Rat Myocardium Identification by Binding of [ 3 H ] (2005) (3)
Chapter 23. Recent Developments in Adrenergic Receptor Research (1980) (3)
Desensitization of the β-Adrenergic Coupled Adenylate Cyclase. The β-Adrenergic Receptor Kinase Phosphorylates Agonist-Occupied Cyclase-Coupled Receptors (1987) (3)
Morphologic demonstration of clathrin-coated pits in frog and turkey erythrocytes. (1984) (3)
Affinity chromatography of adrenergic receptors and binding proteins. (1974) (2)
Tyrosine phosphorylation of G protein a subunits by pp 6 Oc-src { guanosine 5 '-[ l-thio ] triphosphate binding / GTPase activity / stimulatory guanine nucleotide-binding regulatory protein a subunit ( H 2 la ) } (2)
Cell-free Desensitization of Catecholamine-sensitive Adenylate (1984) (2)
- Arrestin and Mdm 2 Mediate IGF-1 Receptor-stimulated ERK Activation and Cell Cycle Progression * (2007) (2)
The receptor kinase family: Primary structure of rhodopsin kinase reveals similarities to the f8-adrenergic receptor kinase (ganine protein-coupled receptors/desensitization/serine/threonine (2)
The adrenergic receptors. (1990) (2)
Adrenergic receptors : molecular properties and therapeutic implications : proceedings symposium St.-Paul-de-Vence, France, October 21st - 24th, 1984 (1985) (2)
Reconstitution of the beta-adrenergic receptor. (1985) (2)
Molecular biology of adrenergic receptors in the rat and frog central nervous system. (1984) (2)
G proteins. The subunit story thickens. (1992) (2)
Inhibition of Spontaneous b2-Adrenergic Activation Rescues b1-Adrenergic Contractile Response in Cardiomyocytes (2000) (2)
Inhibition of the @-Adrenergic Receptor Kinase by Polyanions* (2001) (2)
Role of the beta-adrenergic receptor kinase in desensitization of the alpha 2-adrenergic receptor. (1991) (2)
The GPCR–β-arrestin complex allosterically activates C-Raf by binding its amino terminus (2021) (2)
DEVELOPMENT OF AN AFFINITY LIGAND FOR PURIFICATION OF α2-ADRENOCEPTORS FROM HUMAN PLATELET MEMBRANES (1984) (2)
Multiple effects of N, N' dicyclohexyl carbodiimide on the beta-adrenergic receptor--adenylate cyclase system in frog erythrocytes. (1978) (2)
10 Regulation of Receptor Function (1987) (2)
The Function and Regulation of the G-Protein-Coupled Receptor Kinases (1998) (2)
Cloning andexpression ofahumankidney cDNAforan a2-adrenergic receptor subtype (1988) (2)
Dihydroergocryptine binding and α-adrenoreceptors in smooth muscle (1980) (2)
Partially Purified and Reconstituted G-Protein Coupled Receptors as Substrates of Specific Receptor Kinases (1994) (2)
A conversation with Robert Lefkowitz, Joseph Goldstein, and Michael Brown. Interview by Ushma S. Neil and Howard A. Rockman. (2012) (2)
Editorial: Smoking, catecholamines, and the heart. (1976) (2)
A reconstitution assay for the guanine nucleotide regulatory protein of the adenylate cyclase system using turkey erythrocyte membranes as the acceptor preparation. (1982) (2)
Potentiation of (cid:98) -Adrenergic Signaling by Adenoviral-mediated Gene Transfer in Adult Rabbit Ventricular Myocytes (1997) (2)
2001: An AAP (Association of American Physicians) odyssey. (2001) (2)
An interview with Robert J. Lefkowitz. (2012) (2)
Techniques for the study of the biochemical basis of drug action. (1976) (2)
Catecholamine binding to the fl-adrenergic receptor (stereospecific binding/agonist/frog (2)
Cloning of the CDNA for the human f 31-adrenergic receptor ( catecholamines / transmembrane signaling / receptor subtypes ) (2)
Adenylate cyclase coupled beta-adrenergic receptors: biochemical mechanisms of desensitization. (1986) (2)
Olfactory receptors and the desensitization proteins alpha-rk-2 and beta-arrestin-2 colocalize in mammalian sperm (1994) (1)
Alfred Goodman Gilman (1941–2015) (2016) (1)
Editorial: Selectivity in beta-adrenergic responses: clinical implications. (1974) (1)
PHARMACOLOGICAL ACTIVITY OF NITROXIDE ANALOGS OF DICHLOROISOPROTERENOL AND PROPRANOLOL (1977) (1)
Identification of Cardiac f3-Adrenergic Receptors by (-) [3H]Alprenolol Binding * (stereospecificity/binding kinetics/ft-adrenergic agonists/36-adrenergic antagonists) (1)
Antibodies to the f 8-adrenergic receptor : Attenuation of catecholamine-sensitive adenylate cyclase and demonstration of postsynaptic receptor localization in brain ( adenylate cyclase-coupled receptor / immunocytochemical localization / radioimmunoassay ) (1)
Biochemical and Molecular Characteristics of β-Adrenergic Receptor Binding Sites (1976) (1)
Homologous desensitization of adenylate cyclase: the role of. beta. -adrenergic receptor phosphorylation and dephosphorylation (1986) (1)
Push! Pull! Stop! Go! : A book about forces and motion (1975) (1)
Response:Analysis of ligand binding specificity of receptor chimeras (1989) (1)
Mechanisms for Regulation of β-Adrenergic Receptor Function in Desensitization (1980) (1)
The adrenergic receptors: structure/function and regulation (1990) (1)
MOLECULAR CLONING AND EXPRESSION OF A NEW ALPHA-1-ADRENERGIC RECEPTOR SUBTYPE (1990) (1)
Cell‐free Desensitization of the β‐Adrenergic Receptor: Evidence that Multiple Protein Kinases Can Phosphorylate and Desensitize the Receptor (1986) (1)
Identification and Characterization of Beta-Adrenergic Receptors in Myocardium Under Normal and Pathologic Conditions (1981) (1)
Photoaffinity labeling of human platelet and rabbit kidney alpha 2-adrenoceptors with [3H]SKF 102229. (1986) (1)
Effects of membrane perturbation on beta adrenergic receptor binding and adenylate cyclase activation (1975) (1)
Adrenergic receptors. (1990) (1)
Synthesis of Iodine‐125 Labeled (±)‐15‐(4‐Azidobenzyl)carazolol: A Potent β‐Adrenergic Photoaffinity Probe. (1984) (1)
Platelet Alpha-Adrenergic Receptors: Direct Identification by [3H] Dihydroergocryptine (1977) (1)
The Gordon Wilson lecture. Adrenergic receptors: regulation at the biochemical, physiological and clinical levels. (1983) (1)
- βARK: β-Adrenergic receptor kinases (vertebrates) (1995) (1)
1 -adrenergic receptor association with PSD-95: inhibition of receptor internalization and facilitation of 1-adrenergic receptor interaction with NMDA receptors (2000) (1)
The β-Adrenergic Receptor:Elucidation of Its Molecular Structure (1985) (1)
Resonating to the music of ubiquitination (2004) (1)
Molecular Mechanism of Biased Signaling in a Prototypical G-protein-coupled Receptor (2020) (1)
Arylazide photoaffinity probe for alpha 2-adrenoceptors. (1985) (1)
Myocardial expression of a constitutively active alB-adrenergic receptor in transgenic mice induces cardiac hypertrophy ( Catecol . mleS / phospholpase C ) (1)
The β-Adrenergic Receptor-Coupled Adenylate Cyclase: Reconstitution of the Functional Interactions of the Various Purified Components (1986) (1)
Sympathetic Nervous System, Catecholamine Receptors, and Hypertension (1981) (1)
Chemical modification of alpha 2-adrenoceptors. Possible role for tyrosine in the ligand binding site. (1986) (1)
Molecular characterization of the β-adrenergic receptor of frog erythrocytes (1982) (1)
Absence of effect of cardiac denervation and induced right ventricular failure on canine myocardial norepinephrine binding sites. (1975) (1)
Thrombin receptor. Variations on a theme. (1991) (1)
MYOCARDIAL BETA-ADRENERGIC RECEPTORS FROM ADRENALECTOMIZED RATS: AGONIST-RECEPTOR COMPLEXES (1981) (1)
Antibodies raised against purified beta-adrenergic receptors specifically bind beta-adrenergic ligands. (1979) (1)
Peripheral alpha-adrenergic receptor subtypes. (1980) (1)
Agonist-promoted desensitization and phosphorylation of. cap alpha. /sub 1/-adrenergic receptors coupled to stimulation of phosphatidylinositol metabolism (1986) (1)
Marc G. Caron (1946–2022) (2022) (1)
The mammalian beta-adrenergic receptors. (1989) (1)
Structure of beta2 adrenoceptor bound to carazolol and inactive-state stabilizing nanobody, Nb60 (2016) (1)
Biochemical mechanisms of hormone receptor-effector coupling. Introduction. (1982) (1)
Crystal structure of active Beta‐arrestin1 bound to phosphorylated carboxy‐terminus of a G protein‐coupled receptor (2013) (1)
Molecular properties of alpha 2 adrenergic receptors (1983) (0)
Structure of the M2 muscarinic receptor–β-arrestin complex in a lipid nanodisc (2020) (0)
An approach to the study of G-protein-coupled receptor kinases : An in vitro-purified membrane assay reveals differential receptor specificity and regulation by GI 8 y subunits ( phosphorylation assay / receptor kinase specificity ) (0)
Molecular pharmacology of adenylate cyclase coupled alpha adrenergic and beta adrenergic receptors (1981) (0)
Comparative ratesofdesensitization of13-adrenergic receptors by thefJ-adrenergic receptor kinase andthecyclic AMP-dependent protein kinase (1991) (0)
β-arrestin 1 regulates β2-adrenergic receptor-mediated skeletal muscle hypertrophy and contractility (2018) (0)
A Phenogenetic Study of the Lozenge Pseudoalleles in Drosophila Melanogaster. II. Effects on the Development of Tarsal Claws in Heterozygotes. (1956) (0)
Phosphorylation / dephosphorylation of the jB-adrenergic receptor regulates its functional coupling to adenylate cyclase and subcellular distribution ( homologous desensitization / hormone receptor / receptor sequestration / protein phosphatase ) (0)
Variable phenotypic expression of mutations in genes of the immune system (2005) (0)
678 Biased CXCR3 ligands differentially alter allergic contact hypersensitivity and chemotaxis (2017) (0)
GPCR-Beta arrestin structure in lipid bilayer (2020) (0)
A small region of the /3-adrenergic receptor is selectively involved in its rapid regulation (sequestration/phosphorylation/desensitization) (2016) (0)
Structure of synthetic nanobody-stabilized angiotensin II type 1 receptor bound to TRV026 (2020) (0)
Photoaffinity labeling of mammalian. cap alpha. /sub 1/-adrenergic receptors: identification of the ligand binding subunit with a high affinity radioiodinated probe. [Rats, guinea pigs, rabbits] (1984) (0)
Stabilized beta-arrestin 1-V2T subcomplex of a GPCR-G protein-beta-arrestin mega-complex (2019) (0)
Molecular characterization of the beta-adrenergic receptor of frog erythrocytes. (1982) (0)
Molecular Properties and Regulation of Alpha- and Beta-Adrenergic Receptors (1978) (0)
cAMP stimulates transcription of the f 82-adrenergic receptor gene in response to short-term agonist exposure ( transcriptional activation / second messenger / epinephrine / transfection / down-regulation ) (0)
Additions and Corrections-Development of an Affinity Ligand for Purification of Adrenoceptors from Human Platelet Membranes (1984) (0)
Learn cabin applicable reduction of cholesterol with Bacillus coagulans spores un systems compositions (1999) (0)
Loss of Biased Signaling Specificity of the Angiotensin II Type 1 Receptor in Overexpressed Systems (2022) (0)
The molecular basis of adrenergic receptor function (1990) (0)
Biochemical Characterization of the Cloned Human 5-HT1A Receptor Expressed in Mammalian Cells (1990) (0)
- RhK: Rhodopsin kinase (vertebrates) (1995) (0)
Altering Adrenergic Signaling and Cardiac Function in Transgenic Mice (1998) (0)
718-3 Cardiac Overexpression of βARK in Transgenic Mice Inhibits Isoproterenol Stimulated Contractility In Vivo (1995) (0)
Abstract 3393: A Modified {beta}1-adrenergic Receptor Demonstrates Bias Towards G Protein Receptor Kinase Phosphorylation (2009) (0)
B2V2R-Gs protein subcomplex of a GPCR-G protein-beta-arrestin mega-complex (2019) (0)
Regulation of Myocardial bARK1 Expression in Catecholamine-Induced Cardiac Hypertrophy in Transgenic Mice Overexpressing a1B-Adrenergic Receptors (2016) (0)
A signal honour (2012) (0)
- Palmer ( PTH 1 R ) Promotes Bone Formation Independent of G Protein Activation Biased Agonist of the Parathyroid Hormone Receptor −-Arrestin β A (2009) (0)
Identification and regulation of beta-adrenergic receptors. (1978) (0)
Adrenergic Signaling and Function β Hybrid Transgenic Mice Restores Normal-Adrenergic Receptor Kinase Activity in β In Vivo Inhibition of Elevated Myocardial (1999) (0)
Crystal Structure of the complex between G Protein-Coupled Receptor Kinase 2 and Heterotrimeric G Protein beta 1 and gamma 2 subunits (2003) (0)
Angiotensin analogs with divergent bias stabilize distinct receptor conformations, Wingler et al. (2019) (0)
Photoaffinity labeling of beta-adrenergic receptors in mammalian tissues. (1984) (0)
Agonist-induced increase in apparent f 3-adrenergic receptor size ( hormone receptor / adenylate cyclase / ligand-induced molecular interconversions / guanine nucleotides ) (0)
Direct studies of beta-adrenergic receptors intact frog erythrocytes. (1976) (0)
Science Signaling Podcast: 20 November 2012 (2012) (0)
Historical Background and Introduction (2006) (0)
Models for Regulation of Signal Transduction Processes (2005) (0)
Targeting β-arrestin2 Enhances Survival in a Murine Model of Chronic Myeloid Leukemia (2013) (0)
j3-Adrenergic receptor kinase: Identification ofanovelprotein kinase thatphosphorylates theagonist-occupied form (1986) (0)
THE MIRROR-NEURON SYSTEM IN MONKEYS F 5 (2005) (0)
Cloning and expression of a human kidney cDNA for an a 2-adrenergic receptor subtype ( G protein / photoaffinity labeling / [ 3 Hjrauwolscine binding / a 2-adrenoceptor / a 2 B-adrenergc receptor ) (0)
Membrane-bound hormone receptor purification and characterization by HPLC (2020) (0)
NON-CANONICAL ANGIOTENSIN II TYPE 1A RECEPTOR-MEDIATED, BETA-ARRESTIN2-DEPENDENT SIGNALING CONTRIBUTES TO THORACIC AORTIC ANEURYSM FORMATION IN A MURINE MODEL OF MARFAN SYNDROME (2014) (0)
Conformational Changes in β‐arrestin1: The Importance of β‐arrestin1’s N‐domain (2006) (0)
Regions of the a1-adrenergic receptor involved in coupling to phosphatidylinositol hydrolysis and enhanced sensitivity of biological function (182-adrenergic receptor/guanine nucleotide-binding protein/phospholipase C/constitutive activity) (2016) (0)
Thereceptor kinase family: Primary structure ofrhodopsin kinase reveals similarities tothef8-adrenergic receptor kinase (1991) (0)
Structural basis of fi-adrenergic receptor subtype specificity studied with chimeric 81 / f 82-adrenergic receptors (0)
OPMENT OF TARSAL CLAWS IN HETEROZYGOTES1 (2003) (0)
Human platelet adenylate cyclase: delineation of distinct stimulatory and inhibitory guanine nucleotide regulatory pathways. (1982) (0)
LB987 New insights into gpcr-transducer coupling (2017) (0)
- Adrenergic Receptor Stimulation and Blockade β Expression by Coupled Receptor Kinase − Reciprocal In Vivo Regulation of Myocardial G Protein (1998) (0)
2 – The β-Adrenergic Receptor System: A Model for the Transmembrane Regulation of Adenylate Cyclase (1982) (0)
Isolation and characterization of the beta-adrenergic receptor of frog erythrocytes and development of potential affinity ligands. (1981) (0)
Special issue: Allosterism and Collateral Efficacy b-Arrestin-biased ligands at seven-transmembrane receptors (2007) (0)
THE α1-ADRENERGIC RECEPTOR SUBTYPE COUPLES TO PHOSPHOLIPASE C (1991) (0)
So Long Llamas: Structure of Activated Angiotensin Receptor Stabilized by a Synthetic Nanobody (2020) (0)
Separation, identification and characterization of two structural domains of the mammalian. beta. /sub 2/-adrenergic receptor (1986) (0)
Establish a Barcode That Encodes Differential Functions of { beta }-Arrestin Distinct Phosphorylation Sites on the { beta } 2-Adrenergic Receptor ` (2011) (0)
Differences in the carbohydrate chains of mammalian beta 1 and beta 2 adrenergic receptors (1984) (0)
The molecular size of adenylate cyclase in the absence and presence of nucleotide and hormone effectors. (1979) (0)
P-Arrestin 1 and 2 differentii receptor signaling and traffic (2016) (0)
GPCR signaling: conformational activation of arrestins (2018) (0)
Receptor Binding Studies of Beta-Adrenergic Receptors: New Insights into Activation and Desensitization of Adenylate Cyclase (1979) (0)
1-Adrenergic Stimulation α-but not β Hypertrophy : Regulation by-Adrenergic Receptor Kinase-1 Levels in Catecholamine-Induced Myocardial (1999) (0)
Biophysical Society Congratulates Member Brian Kobilka on Winning the Nobel Prize in Chemistry (2012) (0)
Affinity chromatography of the beta-adrenergic receptor and characterization of antibodies raised against purified receptor preparations. (1980) (0)
Abstract 888: {beta}-Arrestin mediated {beta}1-Adrenergic Receptor Transactivation of the Epidermal Growth Factor Receptor Requires GRK 5 and 6 (2006) (0)
Molecular Cloning and Expression of the cDNA for the cula-Adrenergic Receptor (2001) (0)
Loss of biased signaling at a G protein-coupled receptor in overexpressed systems (2023) (0)
Coupling of (cid:98) 2 -Adrenoceptor to G i Proteins and Its Physiological Relevance in Murine Cardiac Myocytes (1999) (0)
Structure of beta2 adrenoceptor bound to carazolol and an intracellular allosteric antagonist (2017) (0)
Purification, characterization and reconstitution of the adenylate cyclase-coupled β-adrenergic receptor (1984) (0)
Differential Effects on Susceptibility to Ischemic Injury ARK 1 ) Inhibitor Both Increase Myocardial Contractility but Have β Receptor Kinase-1 (-Adrenergic β-Adrenergic Receptor and Expression of a 2 β Overexpression of the Cardiac (1999) (0)
[beta]‐arrestin 1 mediates angiotensin II induced ubiquitination and down‐regulation of TRPV4 (2009) (0)
Methods of Sequestering βγ in the Intact Cell (2020) (0)
Molecular properties of beta 1 adrenergic and beta 2 adrenergic receptors revealed by photo affinity labeling (1982) (0)
Receptor Kinase 6 Mice Deficient for G Protein-Coupled-Induced Chemotaxis , and Signaling in 4 B Increased Acute Inflammation , Leukotriene (2003) (0)
Expression of a G protein-coupled receptors in yeast. (1991) (0)
In Vivo Inhibition of Elevated Myocardial (cid:98) -Adrenergic Receptor Kinase Activity in Hybrid Transgenic Mice Restores Normal (cid:98) -Adrenergic Signaling and Function (1999) (0)
Inhibition of fi-adrenergic receptor kinase prevents rapid homologous desensitization of f 82-adrenergic receptors ( A 431 celis / permeabilization / receptor phosphorylation / heparin ) (0)
Signaling in Lesion Development Inhibitor Suggests a Major Role of G Protein γβ Hyperplasia in Vein Grafts by a G G Protein Signaling and Vein Graft Intimal Hyperplasia : Reduction of Intimal (1998) (0)
J018 The deubiquitinases USP33 and USP20 collaboratively regulate beta2 adrenergic receptor recycling and resensitization (2009) (0)
Adenoviral mediated overexpression of human β2 adrenergic receptor after direct delivery into canine myocardium (1996) (0)
THE BETA-ADRENERGIC RECEPTOR OF FROG ERYTHROCYTE: PURIFICATION BY BIOSPECIFIC AFFINITY CHROMATOGRAPHY (1979) (0)
Science Translational Medicine Podcast: 7 October 2009 (2009) (0)
Structure of synthetic nanobody-stabilized angiotensin II type 1 receptor bound to TRV023 (2020) (0)
Receptor Regulation : Receptors and Recognition Series B: Volume 13 (1982) (0)
Phorbol esters promote a 1-adrenergic receptor phosphorylation and receptor uncoupling from inositol phospholipid metabolism ( smooth muscle / DDT , MF-2 cell line / catecholamines / afflinity chromatography / photoaffinity labeling ) (0)
Structure of beta2 adrenergic receptor bound to BI167107, Nanobody 6B9, and a positive allosteric modulator (2019) (0)
β-Adrenergic Receptor Kinase, β-Arrestin, and cGMP as Mediators of Olfactory Desensitization (1994) (0)
Purification and reconstitution of the human platelet. cap alpha. /sub 2/-adrenergic receptor (1986) (0)
β-arrestin2 Is Necessary for Development of MPLW515L Mutant Primary Myelofibrosis (2015) (0)
The Endocrine Society 2001 annual awards. (2001) (0)
Structure of synthetic nanobody-stabilized angiotensin II type 1 receptor bound to angiotensin II (2020) (0)
Identification and sequence of a binding site peptide of the .beta.2-adrenergic receptor [Erratum to document cited in CA108(15):126956h] (1988) (0)
A cardiac β-adrenergic binding protein: Identification, characterization, solubilization, and purification by affinity chromatography (1973) (0)
Structure of nanobody-stabilized angiotensin II type 1 receptor bound to S1I8 (2019) (0)
List of Contributors and Discussants (1981) (0)
Response : Analysis of Ligand Binding Specificity of Receptor Chimeras (1989) (0)
Collier bankruptcy exemption guide (2001) (0)
Issue Information (1994) (0)
Matter all around you : a book about solids, liquids, & gases (1972) (0)
Contents Silver Spoons and Other Personal Reflections (2013) (0)
Abstract 1533: {beta}-arrestins Regulate Proliferation and Migration of Smooth Muscle Cells in vitro & in vivo: Isoform-specific Roles (2006) (0)
An interview with Professor Robert J. Lefkowitz, M.D. Interview by Vicki Glaser. (2003) (0)
News in brief (1980) (0)
Forces in the earth : a book about gravity and magnetism (1976) (0)
functions of p-arrestins demonstrated by RNA interference (2016) (0)
Royal academy of medicine in Ireland section of surgery (1998) (0)
Humerus of Robust Australopithecus (2005) (0)
Focus on the research journey. An interview with Robert J. Lefkowitz, MD, scientist, mentor, and recipient of the 2007 National Medal of Science by Elaine Musgrave. (2009) (0)
Isoproterenol enhances phosphorylation of pure β-adrenergic receptor by cAMP-dependent protein kinase (1984) (0)
Abstract MP133: Development of β-arrestin-biased Positive Allosteric Modulators for the β 1 Adrenergic Receptor (2020) (0)

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