Robert M. Stroud

Q: What Schools Are Affiliated With Robert M. Stroud

Robert M. Stroud is affiliated with the following schools: University of Cambridge, University of Alabama, University of California, Berkeley, Birkbeck, University of London, University of Oxford, University of Minnesota, University of Colorado, University of California, San Francisco, Akita Prefectural University

Robert M. Stroud's AcademicInfluence.com Rankings

Robert M. Stroud

Physics

#2638

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#3862

Historical Rank

Biophysics

#63

World Rank

#67

Historical Rank

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Physics

Robert M. Stroud's Degrees

PhD Biophysics University of Oxford

Why Is Robert M. Stroud Influential?

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According to Wikipedia, Robert Michael Stroud is a British biophysicist. He was elected to the National Academy of Sciences in 2003. Early life and education Robert Michael Stroud was born in Stockport, England in 1942. He had an early interest in astronomy and would stargaze through his telescope in his garden. He worked with his father, an engineer, to design and build electronic devices. He attended Cambridge University where he studied in physics and mathematics, graduating in 1964. For his graduate studies he attended J.D.Bernal's laboratory at Birkbeck College in London, where he occupied the desk that had been Rosalind Franklin's desk during her time as a researcher there. His thesis concerned defining the structures of nucleosides and peptides. He discerned the crystal structure of the molecule tubercidin with non-centrosymmetric direct methods. He finished his PhD at Birkbeck in 1968.

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Robert M. Stroud's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

A SARS-CoV-2 Protein Interaction Map Reveals Targets for Drug-Repurposing (2020) (3012)
Structure of a glycerol-conducting channel and the basis for its selectivity. (2000) (968)
Control of the Selectivity of the Aquaporin Water Channel Family by Global Orientational Tuning (2002) (783)
The signal recognition particle. (2001) (646)
Mechanism of Ammonia Transport by Amt/MEP/Rh: Structure of AmtB at 1.35 Å (2004) (615)
The unfolded protein response signals through high-order assembly of Ire1 (2009) (597)
On the mechanism of sensing unfolded protein in the endoplasmic reticulum. (2005) (532)
Efficiency of signalling through cytokine receptors depends critically on receptor orientation (1998) (520)
Annual review of biophysics and biomolecular structure (1992) (482)
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms (2020) (444)
Amphipathic analysis and possible formation of the ion channel in an acetylcholine receptor. (1984) (424)
Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: a model for viral DNA binding. (2000) (409)
Site-directed ligand discovery. (2000) (374)
Atomic structure of thymidylate synthase: target for rational drug design. (1987) (303)
Substrate twinning activates the signal recognition particle and its receptor (2004) (299)
Crystal structure of human aquaporin 4 at 1.8 Å and its mechanism of conductance (2009) (298)
Crystal Structure of the Signal Sequence Binding Subunit of the Signal Recognition Particle (1998) (298)
C1q: Rapid Purification Method for Preparation of Monospecific Antisera and for Biochemical Studies (1971) (294)
Structure-based discovery of inhibitors of thymidylate synthase. (1993) (292)
Architecture and Selectivity in Aquaporins: 2.5 Å X-Ray Structure of Aquaporin Z (2003) (288)
Structure of Cry2Aa suggests an unexpected receptor binding epitope. (2001) (278)
The channel architecture of aquaporin 0 at a 2.2-A resolution. (2004) (269)
Aquaporin 4-Specific T Cells in Neuromyelitis Optica Exhibit a Th17 Bias and Recognize Clostridium ABC Transporter (2012) (266)
Structure and function of an acetylcholine receptor. (1982) (255)
Crystal structure of colicin Ia (1997) (249)
The structure of bovine trypsin : Electron density maps of the inhibited enzyme at 5 Å and at 2·7 Å resolution☆ (1974) (246)
Nicotinic acetylcholine receptor superfamily of ligand-gated ion channels. (1990) (241)
Domain structure of 3-hydroxy-3-methylglutaryl coenzyme A reductase, a glycoprotein of the endoplasmic reticulum. (1985) (241)
Structure of the conserved GTPase domain of the signal recognition particle (1997) (235)
Targeting proteins to membranes: structure of the signal recognition particle. (2005) (226)
Regulation of an enzyme by phosphorylation at the active site. (1991) (226)
Catalytic mechanism of NADP(+)-dependent isocitrate dehydrogenase: implications from the structures of magnesium-isocitrate and NADP+ complexes. (1991) (219)
Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer (2014) (219)
Structure, multiple site binding, and segmental accommodation in thymidylate synthase on binding dUMP and an anti-folate. (1990) (212)
Crystal structure of a eukaryotic phosphate transporter (2013) (201)
Structure of a bacterial enzyme regulated by phosphorylation, isocitrate dehydrogenase. (1989) (199)
Pyrrolidine carboxamides as a novel class of inhibitors of enoyl acyl carrier protein reductase from Mycobacterium tuberculosis. (2006) (195)
The structure of a ketoreductase determines the organization of the beta-carbon processing enzymes of modular polyketide synthases. (2006) (193)
Structure at 2.5 A of a designed peptide that maintains solubility of membrane proteins. (1993) (190)
The three-dimensional structure of Asn102 mutant of trypsin: role of Asp102 in serine protease catalysis. (1988) (189)
Function of human Rh based on structure of RhCG at 2.1 Å (2010) (189)
Lateral opening of a translocon upon entry of protein suggests the mechanism of insertion into membranes (2010) (179)
Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: Versatility from a unique substrate channel (2001) (179)
The molecular neurobiology of the acetylcholine receptor. (1986) (174)
Inaugural Article: On the mechanism of sensing unfolded protein in the endoplasmic reticulum (2005) (168)
Structural studies of a membrane-bound acetylcholine receptor from Torpedo californica. (1977) (168)
Structure of bovine trypsinogen at 1.9 A resolution. (1977) (166)
Crystal structure and molecular modeling of 17-DMAG in complex with human Hsp90. (2003) (165)
Structure and specific binding of trypsin: comparison of inhibited derivatives and a model for substrate binding. (1974) (165)
Structural basis for conductance by the archaeal aquaporin AqpM at 1.68 A. (2005) (156)
Crystal structure of the aquaglyceroporin PfAQP from the malarial parasite Plasmodium falciparum (2008) (154)
An antibiotic factory caught in action (2004) (154)
The crystal structure of alpha-bungarotoxin at 2.5 A resolution: relation to solution structure and binding to acetylcholine receptor. (1986) (152)
Mechanism of inhibition of human glucose transporter GLUT1 is conserved between cytochalasin B and phenylalanine amides (2016) (150)
Fabs enable single particle cryoEM studies of small proteins. (2012) (147)
A family of protein-cutting proteins. (1974) (142)
Structural basis of aquaporin inhibition by mercury. (2007) (140)
Acetylcholine receptor structure, function, and evolution. (1985) (140)
Family of G protein α chains: amphipathic analysis and predicted structure of functional domains (1986) (138)
Structural and functional conservation between yeast and human 3-hydroxy-3-methylglutaryl coenzyme A reductases, the rate-limiting enzyme of sterol biosynthesis (1988) (134)
TARP Auxiliary Subunits Switch AMPA Receptor Antagonists into Partial Agonists (2007) (132)
Catalysis, specificity, and ACP docking site of Streptomyces coelicolor malonyl-CoA:ACP transacylase. (2003) (130)
Immunospecific identification and three-dimensional structure of a membrane-bound acetylcholine receptor from Torpedo californica. (1979) (129)
Design of potent selective zinc-mediated serine protease inhibitors (1998) (129)
Mechanism of action of the C3b inactivator: requirement for a high molecular weight cofactor (C3b-C4bINA cofactor) and production of a new C3b derivative (C3b'). (1977) (129)
Plastic adaptation toward mutations in proteins: Structural comparison of thymidylate synthases (1990) (129)
Structure of tRNA pseudouridine synthase TruB and its RNA complex: RNA recognition through a combination of rigid docking and induced fit (2003) (122)
Domain flexibility in retroviral proteases: structural implications for drug resistant mutations. (1998) (118)
Inhibitory complex of the transmembrane ammonia channel, AmtB, and the cytosolic regulatory protein, GlnK, at 1.96 Å (2007) (117)
Subnanometre-resolution electron cryomicroscopy structure of a heterodimeric ABC exporter (2014) (116)
A general protocol for the crystallization of membrane proteins for X-ray structural investigation (2009) (115)
A designed four helix bundle protein with native-like structure (1997) (112)
Lessons and conclusions from dissecting the mechanism of a bisubstrate enzyme: thymidylate synthase mutagenesis, function, and structure. (2003) (112)
Cleavage of C4b by C3b inactivator: production of a nicked form of C4b, C4b', as an intermediate cleavage product of C4b by C3b inactivator. (1980) (110)
Mechanism of Association and Reciprocal Activation of Two GTPases (2004) (110)
Structure of sugar-bound LacY (2014) (109)
Signal sequence recognition and protein targeting. (1999) (107)
Comparison of human solute carriers (2010) (107)
Substrates Control Multimerization and Activation of the Multi-Domain ATPase Motor of Type VII Secretion (2015) (106)
Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases. (2002) (105)
A Unique RNA Fold in the RumA-RNA-Cofactor Ternary Complex Contributes to Substrate Selectivity and Enzymatic Function (2005) (104)
The Crystal and Molecular Structure of DIP-inhibited Bovine Trypsin at 2.7Å Resolution (1972) (104)
The accuracy of refined protein structures: comparison of two independently refined models of bovine trypsin (1978) (101)
C1r deficiency: an inborn error associated with cutaneous and renal disease. (1972) (98)
Crystal structure of human thymidylate synthase: a structural mechanism for guiding substrates into the active site. (1995) (96)
Projected structure of purple membrane determined to 3.7 A resolution by low temperature electron microscopy. (1981) (96)
Structure of bovine pancreatic cholesterol esterase at 1.6 A: novel structural features involved in lipase activation. (1998) (95)
Conformational dynamics along an enzymatic reaction pathway: thymidylate synthase, "the movie". (2003) (94)
Mechanisms of zymogen activation. (1977) (94)
Structure, inhibition, and regulatory sites of TPC1 from Arabidopsis thaliana (2016) (94)
Topological mapping of acetylcholine receptor: evidence for a model with five transmembrane segments and a cytoplasmic COOH-terminal peptide. (1985) (93)
Solvent structure in crystals of trypsin determined by X‐ray and neutron diffraction (1992) (92)
Mechanistic Diversity of Cytokine Receptor Signaling Across Cell Membranes (2004) (91)
Food-induced (allergic) arthritis. Inflammatory arthritis exacerbated by milk. (1986) (91)
Chemical studies of Clq; a modulator of immunoglobulin biology. (1971) (90)
Functional changes in the structure of the SRP GTPase on binding GDP and Mg2+GDP (1999) (90)
Complement and host defense against infection. (1977) (89)
Cleavage of C2 by C1s into the antigenically distinct fragments C2a and C2b: demonstration of binding of C2b to C4b. (1977) (89)
Structural and biochemical insights into the dicing mechanism of mouse Dicer: A conserved lysine is critical for dsRNA cleavage (2008) (87)
Linking regions between helices in bacteriorhodopsin revealed. (1982) (86)
Ultrastructure of the Human Complement Component, Clq (1972) (85)
Regulation of isocitrate dehydrogenase by phosphorylation involves no long-range conformational change in the free enzyme. (1991) (85)
Clq: rapid purification method for preparation of monospecific antisera and for biochemical studies. (1971) (84)
Fungal association and utilization of phosphate by plants: success, limitations, and future prospects (2015) (84)
Unraveling the interface of signal recognition particle and its receptor by using chemical cross-linking and tandem mass spectrometry. (2004) (83)
Tandem facial amphiphiles for membrane protein stabilization. (2010) (82)
Crystalline arrays of membrane-bound acetylcholine receptor. (1981) (81)
Epidermal growth factor (EGF) induces oligomerization of soluble, extracellular, ligand-binding domain of EGF receptor. A low resolution projection structure of the ligand-binding domain. (1991) (81)
The structural basis for tRNA recognition and pseudouridine formation by pseudouridine synthase I (2000) (80)
Structural Basis for Alternating Access of a Eukaryotic Calcium/Proton Exchanger (2013) (80)
Episelection: novel Ki approximately nanomolar inhibitors of serine proteases selected by binding or chemistry on an enzyme surface. (1995) (79)
Structure of a TrmA–RNA complex: A consensus RNA fold contributes to substrate selectivity and catalysis in m5U methyltransferases (2008) (78)
Mode of interaction of different polyanions with the first (C1, C1), the second (C2) and the fourth (C4) component of complement--II. Effect of polyanions on the binding of C2 to EAC4b. (1976) (78)
The unfolded protein response signals through high-order assembly of Ire 1 (2008) (77)
How U38, 39, and 40 of many tRNAs become the targets for pseudouridylation by TruA. (2007) (77)
Mode of interaction of different polyanions with the first (C1, C1), the second (C2) and the fourth (C4) component of complement--III. Inhibition of C4 and C2 binding site(s) on C1s by polyanions. (1976) (77)
Characterization of the 23 S Ribosomal RNA m5U1939 Methyltransferase from Escherichia coli * (2002) (76)
Structural context shapes the aquaporin selectivity filter (2010) (75)
Approaches to solving the rigid receptor problem by identifying a minimal set of flexible residues during ligand docking. (2001) (74)
Deficiency of C1r in human serum. Effects on the structure and function of macromolecular C1. (1970) (74)
Crystal structure of the priming beta-ketosynthase from the R1128 polyketide biosynthetic pathway. (2002) (73)
Pairwise specificity and sequential binding in enzyme catalysis: thymidylate synthase. (1990) (73)
Rabbit C1q: purification, functional and structural studies. (1972) (72)
Structure, inhibition, and regulation of two-pore channel TPC1 from Arabidopsis thaliana (2016) (71)
Structure of Bor1 supports an elevator transport mechanism for SLC4 anion exchangers (2016) (70)
Overexpressing human membrane proteins in stably transfected and clonal human embryonic kidney 293S cells (2012) (69)
Protease effects on the structure of acetylcholine receptor membranes from Torpedo californica (1980) (69)
The structural mechanism for half-the-sites reactivity in an enzyme, thymidylate synthase, involves a relay of changes between subunits. (1999) (69)
Saturation site-directed mutagenesis of thymidylate synthase. (1990) (69)
Structure determination of asymmetric membrane profiles using an iterative Fourier method. (1979) (69)
Metal-induced conformational changes in ZneB suggest an active role of membrane fusion proteins in efflux resistance systems (2010) (68)
Glycerol facilitator GlpF and the associated aquaporin family of channels. (2003) (68)
Effects of detergent environments on the photocycle of purified monomeric bacteriorhodopsin. (1991) (68)
Structural studies on human Clq: non-covalent and covalent subunits. (1972) (67)
Difference Fourier refinement of the structure of DIP‐trypsin at 1.5 Å with a minicomputer technique (1977) (66)
Coordinating the impact of structural genomics on the human α-helical transmembrane proteome (2013) (66)
Refined structures of substrate-bound and phosphate-bound thymidylate synthase from Lactobacillus casei. (1993) (66)
Structural studies of alpha-bungarotoxin. 1. Sequence-specific 1H NMR resonance assignments. (1988) (66)
Purification, Molecular Properties, and Activation of C1 Proesterase, Cls (1973) (66)
Subunit organization and structure of an acetylcholine receptor. (1983) (65)
Ion channel forming colicins. (1995) (65)
Protein structure prediction with a combined solvation free energy-molecular mechanics force field (1993) (64)
Bacteriorhodopsin D85N: three spectroscopic species in equilibrium. (1993) (63)
Attachment site(s) of retinal in bacteriorhodopsin. (1981) (63)
Immune complexes in congenital and natal cytomegalovirus infections of man. (1977) (63)
Structural and functional basis for RNA cleavage by Ire1 (2011) (62)
Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2 (2020) (62)
Cleavage products of C4b produced by enzymes in human serum. (1975) (62)
Mechanism of hydrolysis by serine proteases: direct determination of the pKa's of aspartyl-102 and aspartyl-194 in bovine trypsin using difference infrared spectroscopy. (1976) (61)
The additivity of substrate fragments in enzyme-ligand binding. (1998) (61)
Water-mediated substrate/product discrimination: the product complex of thymidylate synthase at 1.83 A. (1994) (60)
Assembly of bacteriophage T7. Dimensions of the bacteriophage and its capsids. (1981) (59)
The C1q inhibitor in serum is a chondroitin 4-sulfate proteoglycan. (1981) (59)
Phylogenetic Classification of Protozoa Based on the Structure of the Linker Domain in the Bifunctional Enzyme, Dihydrofolate Reductase-Thymidylate Synthase* (2003) (59)
Multi-targeted antifolates aimed at avoiding drug resistance form covalent closed inhibitory complexes with human and Escherichia coli thymidylate synthases. (2001) (59)
Structural basis for recognition of polyglutamyl folates by thymidylate synthase. (1992) (59)
Crystal Structure of the First KH Domain of Human Poly(C)-binding Protein-2 in Complex with a C-rich Strand of Human Telomeric DNA at 1.7 Å* (2005) (58)
Selectivity and conductance among the glycerol and water conducting aquaporin family of channels (2003) (58)
α-Bungaratoxin structure revealed by a rapid method for averaging electron density of non-crystallographically translationally related molecules (1980) (57)
Crystal structure and mechanistic basis of a functional homolog of the antigen transporter TAP (2017) (57)
The Amt/MEP/Rh family: structure of AmtB and the mechanism of ammonia gas conduction. (2006) (57)
The first structure of an RNA m5C methyltransferase, Fmu, provides insight into catalytic mechanism and specific binding of RNA substrate. (2003) (56)
X-ray crystallographic and NMR studies of protein-protein and protein-nucleic acid interactions involving the KH domains from human poly(C)-binding protein-2. (2007) (55)
Effects of Asp-96----Asn, Asp-85----Asn, and Arg-82----Gln single-site substitutions on the photocycle of bacteriorhodopsin. (1991) (53)
Inactivation of C1 in rheumatoid synovial fluid, purfied C1 and C1 esterase, by gold compounds. (1974) (53)
Evidence for a serum inhibitor of Clq. (1975) (51)
Inclusion of solvation free energy with molecular mechanics energy: Alanyl dipeptide as a test case (1992) (50)
Cell‐free complements in vivo expression of the E. coli membrane proteome (2007) (50)
Cofactor triggers the conformational change in thymidylate synthase: implications for an ordered binding mechanism. (1992) (50)
Selecting optimum eukaryotic integral membrane proteins for structure determination by rapid expression and solubilization screening. (2009) (50)
Crystal structure of RumA, an iron-sulfur cluster containing E. coli ribosomal RNA 5-methyluridine methyltransferase. (2004) (49)
Structures of thymidylate synthase with a C-terminal deletion: role of the C-terminus in alignment of 2'-deoxyuridine 5'-monophosphate and 5,10-methylenetetrahydrofolate. (1993) (49)
Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1 (2011) (48)
Three-dimensional structures of HIV-1 and SIV protease product complexes. (1996) (47)
Independent mutations at the amino terminus of a protein act as surrogate signals for mitochondrial import. (1987) (47)
Binding of the anticancer drug ZD1694 to E. coli thymidylate synthase: assessing specificity and affinity. (1996) (47)
New Science Opportunities Enabled by LCLS-II X-ray Lasers (2015) (47)
Prediction of homologous protein structures based on conformational searches and energetics (1990) (46)
Structure-based design of inhibitors specific for bacterial thymidylate synthase. (1999) (46)
Structures of intermediate transport states of ZneA, a Zn(II)/proton antiporter (2013) (46)
Immunodominant T Cell Determinants of Aquaporin-4, the Autoantigen Associated with Neuromyelitis Optica (2010) (46)
Anisotropic dynamics of the JE-2147-HIV protease complex: drug resistance and thermodynamic binding mode examined in a 1.09 A structure. (2002) (46)
CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes. (2021) (45)
Purification of bacteriorhodopsin and characterization of mature and partially processed forms. (1989) (45)
An electrostatic highway (1994) (44)
Structure of an acyl-enzyme intermediate during catalysis: (guanidinobenzoyl)trypsin. (1990) (43)
Atomic structure of a glycerol channel and implications for substrate permeation in aqua(glycero)porins (2001) (43)
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing (2020) (43)
Structure of LacY with an α-substituted galactoside: Connecting the binding site to the protonation site (2015) (43)
Reversible adsorption of C'2 by EAC'4: role of Mg2+, enumeration of competent SAC'4, two-step nature of C'2a fixation and estimation of its efficiency. (1966) (43)
C'2ad, an inactive derivative of C'2 released during decay of EAC'4,2a. (1966) (43)
Conformational states of the nicotinic acetylcholine receptor from Torpedo californica induced by the binding of agonists, antagonists, and local anesthetics. Equilibrium measurements using tritium-hydrogen exchange. (1989) (42)
The role of protein dynamics in thymidylate synthase catalysis: variants of conserved 2'-deoxyuridine 5'-monophosphate (dUMP)-binding Tyr-261. (2006) (41)
A remote mutation affects the hydride transfer by disrupting concerted protein motions in thymidylate synthase. (2012) (41)
Structure, oligosaccharide structures, and posttranslationally modified sites of the nicotinic acetylcholine receptor. (1989) (40)
Redox Reactions of the Iron-Sulfur Cluster in a Ribosomal RNA Methyltransferase, RumA (2004) (38)
Crystal structure of the third KH domain of human poly(C)-binding protein-2 in complex with a C-rich strand of human telomeric DNA at 1.6 Å resolution (2007) (38)
Changes in serum complement and immunoglobulins following cardiopulmonary bypass. (1972) (38)
EspR, a key regulator of Mycobacterium tuberculosis virulence, adopts a unique dimeric structure among helix-turn-helix proteins (2011) (37)
Colicin Ia inserts into negatively charged membranes at low pH with a tertiary but little secondary structural change. (1993) (37)
Crystal Structure of the Human tRNA m(1)A58 Methyltransferase-tRNA(3)(Lys) Complex: Refolding of Substrate tRNA Allows Access to the Methylation Target. (2015) (37)
Enzyme-catalyzed therapeutic agent (ECTA) design: activation of the antitumor ECTA compound NB1011 by thymidylate synthase. (2001) (37)
C1r, subunit of the first complement component: purification, properties, and assay based on its linking role. (1971) (37)
Catalytically-active complex of HIV-1 integrase with a viral DNA substrate binds anti-integrase drugs (2009) (37)
On the structure and mechanism of two‐pore channels (2018) (36)
Purification and characterization of a macromolecular weight cofactor for C3b-inactivator, C4bC3bINA-cofactor, of human plasma. (1980) (36)
Functional consequences of the Kaposi's sarcoma-associated herpesvirus protease structure: regulation of activity and dimerization by conserved structural elements. (2000) (36)
C1 fixation and classical complement pathway activation by a fragment of the Cmu4 domain of IgM (1975) (36)
Structural basis for mobility in the 1.1 A crystal structure of the NG domain of Thermus aquaticus Ffh. (2002) (36)
The relationship of the hemolytic activity of active C'1s to its TAMe esterase action: a new method of purification and assay. (1969) (36)
Tryptophan 80 and leucine 143 are critical for the hydride transfer step of thymidylate synthase by controlling active site access. (2002) (36)
Wild-type and mutant bacteriorhodopsins D85N, D96N, and R82Q: purification to homogeneity, pH dependence of pumping, and electron diffraction. (1991) (35)
Predicting and harnessing protein flexibility in the design of species-specific inhibitors of thymidylate synthase. (2001) (35)
Structural basis for activation of voltage sensor domains in an ion channel TPC1 (2018) (35)
Stereochemistry of a multistep/bipartite methyl transfer reaction: thymidylate synthase (1993) (35)
Substrate Recognition by RNA 5-Methyluridine Methyltransferases and Pseudouridine Synthases: A Structural Perspective* (2006) (35)
Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether (2019) (34)
Efficient expression screening of human membrane proteins in transiently transfected Human Embryonic Kidney 293S cells. (2011) (33)
Access to phosphorylation in isocitrate dehydrogenase may occur by domain shifting. (1997) (33)
Unlocking the eukaryotic membrane protein structural proteome. (2010) (33)
Structure of the protease from simian immunodeficiency virus: complex with an irreversible nonpeptide inhibitor. (1993) (33)
Structure of human pro-chymase: a model for the activating transition of granule-associated proteases. (2003) (33)
Structures suggest a mechanism for energy coupling by a family of organic anion transporters (2019) (32)
Claudin-9 structures reveal mechanism for toxin-induced gut barrier breakdown (2019) (32)
The autosomal recessive mode of inheritance of C1r deficiency in a large Puerto Rican family. (1974) (31)
Highlighting membrane protein structure and function: A celebration of the Protein Data Bank (2021) (31)
Active site water molecules revealed in the 2.1 A resolution structure of a site-directed mutant of isocitrate dehydrogenase. (2000) (31)
THE STRUCTURAL BASIS FOR BINDING OF COMPLEMENT BY IMMUNOGLOBULIN M (1974) (31)
The domain structure of the ion channel-forming protein colicin Ia (1994) (31)
Crystal structure of an Acyl-ACP dehydrogenase from the FK520 polyketide biosynthetic pathway: insights into extender unit biosynthesis. (2003) (31)
The complex of the anti-cancer therapeutic, BW1843U89, with thymidylate synthase at 2.0 A resolution: implications for a new mode of inhibition. (1996) (31)
Significance of structural changes in proteins: Expected errors in refined protein structures (1995) (31)
Structure-based studies on species-specific inhibition of thymidylate synthase. (2002) (30)
Catalysis of C'2 fixation by C'la. Reaction kinetics, competitive inhibition by TAMe, and transferase hypothesis of the enzymatic action of C'la on C'2, one of its natural substrates. (1965) (30)
Human factor D of the alternative complement pathway: purification and characterization. (1977) (30)
A single‐crystal structure determination of dl‐6‐thioctic acid, C8H14O2S2 (1972) (30)
Overexpression and purification of integral membrane proteins in yeast. (2010) (30)
Ion transport and regulation in a synaptic vesicle glutamate transporter (2020) (30)
Crystal structure of thymidylate synthase from T4 phage: component of a deoxynucleoside triphosphate-synthesizing complex. (1994) (30)
Rapid identification of recombinant Fabs that bind to membrane proteins. (2011) (30)
A focusing monochromator for small-angle diffraction studies with synchrotron radiation (1977) (29)
Location of terbium binding sites on acetylcholine receptor-enriched membranes. (1986) (29)
Blood Damage in the Heart-Lung Machine (1971) (27)
Sub-units of the first complement component in immunologic deficiency syndromes: independence of Cls and Clq. (1970) (27)
Crystal Structure of a ligand-bound LacY–Nanobody Complex (2018) (27)
X-ray Structures of the Signal Recognition Particle Receptor Reveal Targeting Cycle Intermediates (2007) (27)
An essential role for water in an enzyme reaction mechanism: the crystal structure of the thymidylate synthase mutant E58Q. (1996) (26)
Structures of SRP54 and SRP19, the Two Proteins that Organize the Ribonucleic Core of the Signal Recognition Particle from Pyrococcus furiosus (2008) (26)
Balancing ATP in the cell (1996) (25)
Interaction of Histoplasma capsulatum with human platelets. (1980) (25)
Modulation of P2X3 and P2X2/3 Receptors by Monoclonal Antibodies* (2016) (25)
Wild-type and mutant bacterioopsins D85N, D96N, and R82Q: high-level expression in Escherichia coli. (1991) (25)
D221 in thymidylate synthase controls conformation change, and thereby opening of the imidazolidine. (1998) (25)
Entropy in bi-substrate enzymes: proposed role of an alternate site in chaperoning substrate into, and products out of, thymidylate synthase. (1996) (24)
Crystal structure of an RluF-RNA complex: a base-pair rearrangement is the key to selectivity of RluF for U2604 of the ribosome. (2009) (24)
The activation of Cls with purified Clr. (1974) (24)
The glycerol facilitator GlpF its aquaporin family of channels, and their selectivity. (2003) (23)
The structure of Enterococcus faecalis thymidylate synthase provides clues about folate bacterial metabolism. (2012) (23)
Silver ion inhibition of serine proteases: crystallographic study of silver-trypsin. (1974) (23)
Computational and structural approaches to drug discovery : ligand-protein interactions (2008) (23)
In human pseudouridine synthase 1 (hPus1), a C-terminal helical insert blocks tRNA from binding in the same orientation as in the Pus1 bacterial homologue TruA, consistent with their different target selectivities. (2013) (23)
The crystal structure of thymidylate synthase from Pneumocystis carinii reveals a fungal insert important for drug design. (2000) (23)
Water and glycerol permeation through the glycerol channel GlpF and the aquaporin family. (2004) (23)
A new class of HIV-1 protease inhibitor: the crystallographic structure, inhibition and chemical synthesis of an aminimide peptide isostere. (1996) (23)
Insights into the Mechanism of Bovine CD38/NAD+Glycohydrolase from the X-Ray Structures of Its Michaelis Complex and Covalently-Trapped Intermediates (2012) (23)
Engineering a soluble extracellular erythropoietin receptor (EPObp) in Pichia pastoris to eliminate microheterogeneity, and its complex with erythropoietin. (1999) (23)
Structure of Cry 2 Aa Suggests an Unexpected Receptor Binding Epitope single order (2006) (23)
Ion channels formed by a highly charged peptide. (1991) (23)
De novo design of an IL-4 antagonist and its structure at 1.9 A. (2005) (22)
LpxI structures reveal how a lipid A precursor is synthesized (2012) (22)
High sensitivity electron diffraction analysis. A study of divalent cation binding to purple membrane. (1990) (22)
Comparative Immunology (1969) (22)
Location of an extrinsic label in the primary and tertiary structure of bacteriorhodopsin. (1984) (22)
The structure of GlpF, a glycerol conducting channel. (2002) (21)
Two-dimensional crystallization of Escherichia coli-expressed bacteriorhodopsin and its D96N variant: high resolution structural studies in projection. (1993) (21)
Hotspots in an obligate homodimeric anticancer target. Structural and functional effects of interfacial mutations in human thymidylate synthase. (2015) (21)
Mapping a membrane-associated conformation of colicin Ia. (1993) (20)
Inhibitor of ovarian cancer cells growth by virtual screening: a new thiazole derivative targeting human thymidylate synthase. (2012) (20)
Phthalein derivatives as a new tool for selectivity in thymidylate synthase inhibition. (1999) (20)
Data collection in protein crystallography: capillary effects and background corrections (1974) (20)
Crystal structure of bovine mitochondrial factor B at 0.96-Å resolution (2008) (19)
A probable linking sequence between two transmembrane components of bacteriorhodopsin (1981) (19)
Structures of the Signal Recognition Particle Receptor from the Archaeon Pyrococcus furiosus: Implications for the Targeting Step at the Membrane (2008) (19)
Use of Argatroban for anticoagulation during cardiopulmonary bypass in a patient with heparin allergy. (2008) (19)
The crystal and molecular structure of tubercidin, C11H14N4O4 (1973) (18)
The mechanism of pseudouridine synthases from a covalent complex with RNA, and alternate specificity for U2605 versus U2604 between close homologs (2013) (18)
STRUCTURE-FUNCTION STUDIES ON HUMAN ALPHA INTERFERON (1982) (18)
General qPCR and Plate Reader Methods for Rapid Optimization of Membrane Protein Purification and Crystallization Using Thermostability Assays (2014) (18)
Detection and quantitation in plasma and synovial fluid of a fragment of human C4 with alpha mobility generated during the activation of the complement system. (1975) (18)
Structure of a new DNA-binding domain which regulates pathogenesis in a wide variety of fungi (2014) (18)
2007 Annual progress report synopsis of the Center for Structures of Membrane Proteins (2009) (17)
Changes in conformation upon agonist binding, and nonequivalent labeling, of the membrane-spanning regions of the nicotinic acetylcholine receptor subunits. (1989) (17)
Mg2+ binds to the surface of thymidylate synthase and affects hydride transfer at the interior active site. (2013) (17)
Recurrent meningococcal meningitis with absence of the sixth component of complement: an evaluation of underlying immunologic mechanisms. (1979) (17)
Replacement set mutagenesis of the four phosphate-binding arginine residues of thymidylate synthase. (2000) (17)
Mechanisms of biological control by phosphorylation (1991) (16)
New tools in membrane protein determination (2011) (16)
A pulsed diffusion technique for the growth of protein crystals for x-ray diffraction. (1975) (16)
A method for preparing monospecific antisera to Cl esterase (Cls): microheterogeneity of purified Cls. (1970) (16)
Crystal Structure and Molecular Modeling of 17-DMAG in Complex with Human Hsp 90 (2006) (16)
Peptide Antidotes to SARS-CoV-2 (COVID-19) (2020) (15)
Partitioning roles of side chains in affinity, orientation, and catalysis with structures for mutant complexes: asparagine-229 in thymidylate synthase. (1996) (15)
Ultrastructure of the human complement component, Clq (negative staining-glutamine synthetase-biologically active Clq). (1972) (15)
Contributions of orientation and hydrogen bonding to catalysis in Asn229 mutants of thymidylate synthase. (1998) (15)
RESONANCE RAMAN SPECTRA OF BACTERIORHODOPSIN MUTANTS WITH SUBSTITUTIONS AT ASP‐85, ASP‐96, AND ARG‐82 (1991) (15)
Structural basis for Clostridium perfringens enterotoxin targeting of claudins at tight junctions in mammalian gut (2021) (14)
Cation binding sites on the projected structure of bacteriorhodopsin. (1986) (14)
The structure of bovine trypsin: electron density maps of the inhibited enzyme at 5 Angstrom and at 2-7 Angstron resolution. (1974) (14)
Helical protein design. (1998) (14)
Identification of Membrane Proteins and Soluble Protein Secondary Structural Elements, Domain Structure, and Packing Arrangements by Fourier-Transform Amphipathic Analysis (1989) (13)
Structure, Elemental Composition and Isotopic Composition of Presolar Silicates in MET 00426 (2009) (13)
A survey of integral α-helical membrane proteins (2009) (13)
A novel dCMP methylase by engineering thymidylate synthase. (1997) (13)
The Crystal Structure of Dihydrofolate Reductase‐Thymidylate Synthase from Cryptosporidium hominis Reveals a Novel Architecture for the Bifunctional Enzyme (2003) (13)
Remotely controlled mirror of variable geometry for small‐angle x‐ray diffraction with synchrotron radiation (1976) (13)
pH dependence of tritium exchange with the C-2 protons of the histidines in bovine trypsin. (1976) (13)
Reversible dissociation and unfolding of the dimeric protein thymidylate synthase (1992) (13)
Ion-channel-forming colicins. (1998) (12)
The crystal structure of E. coli rRNA pseudouridine synthase RluE. (2007) (12)
Cesium ion liquid secondary ion mass spectrometry of membrane-bound glycoproteins: structural and topological considerations of acetylcholine receptor from Torpedo californica. (1988) (12)
Resting state structure of the hyperdepolarization activated two-pore channel 3 (2020) (12)
Expression, purification, and structural characterization of the bacteriorhodopsin-aspartyl transcarbamylase fusion protein. (1999) (12)
The Molecular Structure of C4 and Its Cleavage Products (1976) (12)
CRL4AMBRA1 targets Elongin C for ubiquitination and degradation to modulate CRL5 signaling (2018) (12)
Biochemistry and Biological Reactions of Complement Proteins (1979) (11)
Energetic contributions of four arginines to phosphate-binding in thymidylate synthase are more than additive and depend on optimization of "effective charge balance". (2000) (11)
Insulin and IgG Complexes: An Immunologic Bypass for Complement Activation (1972) (11)
Development and binding mode assessment of N-[4-[2-propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-3H-cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-l-γ-glutamyl-D-glutamic acid (BGC 945), a novel thymidylate synthase inhibitor that targets tumor cells. (2013) (10)
Family of G protein alpha chains: amphipathic analysis and predicted structure of functional domains. (1986) (10)
Crystallization of human thymidylate synthase. (1991) (10)
Crystal structures of a unique thermal-stable thymidylate synthase from Bacillus subtilis. (1998) (10)
The structure of Cryptococcus neoformans thymidylate synthase suggests strategies for using target dynamics for species-specific inhibition. (2005) (10)
A Precise New Method of Microsampling Chondritic Material for Transmission Electron Microscope Analysis: Preliminary Application to Calcium-Aluminum-rich Inclusions and Associated Matrix Material in the Vigarano CV3 Meteorite (2000) (10)
C1 Proesterase (C1s): Purification, Molecular Properties and Activation (1973) (10)
Structural and functional basis for RNA cleavage by Ire 1 (2011) (9)
Evidence that C1s participates in the alternative complement pathway. (1976) (9)
Topochemistry for preparing ligands that dimerize receptors. (1995) (9)
Ratiocinative screen of eukaryotic integral membrane protein expression and solubilization for structure determination (2009) (9)
Transmembrane transporters: An open and closed case (2007) (9)
Structural and Functional Studies of an Acetylcholine Receptor (1975) (8)
Oxygen Isotopic Compositions of Wild 2 Silicates (2008) (8)
The discovery, characterization and crystallographically determined binding mode of an FMOC-containing inhibitor of HIV-1 protease. (1997) (8)
Molecular basis of multistep voltage activation in plant two-pore channel 1 (2022) (8)
A Single Mutation Traps a Half-Sites Reactive Enzyme in Midstream, Explaining Asymmetry in Hydride Transfer. (2018) (8)
Rabbit CRP Production After Inulin Injection 1 (1979) (8)
Specific antisera to Clr. Quantitation of Clr in normal and pathological human sera. (1974) (8)
Generation and enrichment of C4d in whole serum. (1979) (8)
Preparative purification of functional bacteriorhodopsin by high-performance size-exclusion chromatography. (1989) (8)
Tetra Detector Analysis of Membrane Proteins (2014) (8)
Immunochemical quantitation of human Cl esterase (Cls): concentration in normal serum and purification yields. (1970) (7)
Subunit secondary structure in filamentous viruses: predictions and observations. (1984) (7)
The only active mutant of thymidylate synthase D169, a residue far from the site of methyl transfer, demonstrates the exquisite nature of enzyme specificity. (2003) (7)
Alanine mutants of the interface residues of human thymidylate synthase decode key features of the binding mode of allosteric anticancer peptides. (2015) (7)
Comparative Transmission Electron Microscopy Studies of Presolar Silicate and Oxide Grains from the Dominion Range 08006 and Northwest Africa 5958 Meteorites (2014) (7)
Computational Constraints on Syntactic Processing in a Nonhuman Primate (2004) (7)
Purification and Structural Studies of Human Clq. (1971) (7)
Wild-2 Dj-Vu: Comparison of Wild-2 Particles to Chondrites and IDPs (2007) (7)
Studies on the first component of complement (C1) and the inhibitor of C1 esterase in rheumatoid synovial fluids. (1972) (7)
Effects of subunit occupancy on partitioning of an intermediate in thymidylate synthase mutants. (2000) (6)
Preliminary SEM and TEM Study of Pristine Samples of Tagish Lake Meteorite (2009) (6)
Data collection in protein crystallography: experimental methods for reducing background radiation (1976) (6)
A comparative analysis of the C1-binding ability of fragments derived from complement-fixing and noncomplement-fixing IgM proteins. (1976) (6)
Specific antisera to C1s: detection of different electrophoretic species of C1s. (1969) (6)
The structural roles of conserved Pro196, Pro197 and His199 in the mechanism of thymidylate synthase. (2003) (6)
DEFICIENCY OF C1r IN HUMAN SERUM (1970) (6)
Isotopically Anomalous Organic Globules from Comet 81P/Wild 2 (2009) (6)
Contribution of a salt bridge to binding affinity and dUMP orientation to catalytic rate: mutation of a substrate-binding arginine in thymidylate synthase. (1996) (6)
Continued Characterization of Presolar Silicate Grains from the Acfer 094 Carbonaceous Chondrite (2005) (5)
An unusual case of coxsackie B infection. (1962) (5)
Changes in serum complement and the immunoglobulins after cardiopulmonary bypass. (1972) (5)
Inactivity of N229A thymidylate synthase due to water-mediated effects: isolating a late stage in methyl transfer. (1998) (5)
Structure and Composition of Comet Wild 2 Residues in Sub-Micron to Micron-Sized Craters (2010) (5)
The Channel Architecture of Aquaporin O at 2.2 Angstrom Resolution (2004) (5)
Evidence for conformational differences in aqueous and crystalline structures of α-bungarotoxin and cobratoxin (1986) (4)
A carboxy-terminal fragment of colicin Ia forms ion channels (1993) (4)
The Preserved HTH-Docking Cleft of HIV-1 Integrase Is Functionally Critical. (2016) (4)
Deficiency : an Inborn Error Associated with Cutaneous and Renal Disease (4)
Key computational findings reveal proton transfer as driving the functional cycle in the phosphate transporter PiPT (2021) (4)
Transmission Electron Microscopy of a Presolar Corundum Grain (2002) (4)
FIB-TEM Study of a Wark-Lovering Rim in an Allende Type-A CAI (2007) (4)
Transmission Electron Microscopy and Secondary Ion Mass Spectrometry of an Unusual Mg-rich Presolar Al2O3 Grain (2007) (4)
Interaction of Aggregates of Reduced Insulin with Gamma Globulin and Complement (1969) (4)
Error analysis in the biophysical applications of a flatbed autodensitometer (1977) (4)
394 Food-induced (allergic) arthritis, I. Rheumatoid arthritis exacerbated by milk (1985) (4)
Mesoscopic surfactant organization and membrane protein crystallization (2000) (4)
The crystal and molecular structure of DIP-inhibited bovine trypsin at2.7Angstrom resolution. (1972) (3)
Free and total insulin levels in a patient with insulin-resistant diabetes mellitus and chronic lymphatic leukemia: effect of prednisone therapy. (1976) (3)
Asparagine 229 mutants of thymidylate synthase catalyze the methylation of 3-methyl-2'-deoxyuridine 5'-monophosphate. (1996) (3)
Microstructural Investigations of the Cosmochemical Histories of Presolar Grains (2005) (3)
Molecular biology in three dimensions. (1991) (3)
HIV-1 INTEGRASE CATALYTIC CORE AND C-TERMINAL DOMAIN (2000) (3)
The Crystal Structure of Dihydrofolate Reductase-Thymidylate Synthase from Cryptosporidium hominis Reveals a Novel Architecture for the Bifunctional Enzyme (2003) (3)
ISOTOPIC AND CHEMICAL VARIATIONS ON THE NANOSCALE OF DISTINCT LITHOLOGIES FROM THE TAGISH LAKE METEORITE (2010) (2)
Constraining the Origin of Meteoritic Nanodiamond Residues with Single-Atom Sensitivity Electron Microscopy (2011) (2)
The Microstructure of a Presolar Spinel Grain (2010) (2)
15 – A NEW STRATEGY FOR MAPPING THE TOPOGRAPHY OF A TRANSMEMBRANE PROTEIN USING MASS SPECTROMETRY1 (1989) (2)
Mg and Ca Isotopic Anomalies in Presolar Oxides: Large Anomalies in a Group 3 Hibonite Grain (2011) (2)
Disrupters of the Thymidylate Synthase Homodimer Accelerate Its Proteasomal Degradation and Inhibit Cancer Growth. (2021) (2)
Clues to Stellar Evolution from Microscopy of Star Dust (2005) (2)
Topological mapping and the ionic channel in an acetylcholine receptor. (1987) (2)
Small-Scale Screening to Large-Scale Over-Expression of Human Membrane Proteins for Structural Studies. (2016) (2)
The binding and processing of plasminogen by Balb/c 3T3 and SV3T3 cells (1981) (2)
Human Clr, Purification and Assay Based on Its Linking Role (1971) (2)
C3bINA and its Macromolecular Weight Co-factor; Purification and Characterization (1978) (2)
Symmetry reduction in a hyperpolarization-activated homotetrameric ion channel (2021) (2)
In Situ Lift-Out with a Focused-Ion-Beam/Scanning-Electron Microscope: A New Technique for Creating Transmission-Electron-Microscope Samples of Earth and Planetary Materials (2006) (2)
Diversity in kinetics correlated with structure in nano body-stabilized LacY (2020) (2)
Genetic abnormalities of the complement system of man associated with disease. (1974) (2)
Malonyl-CoA:ACP Transacylase (2003) (2)
Model for the ion channel in the acetylcholine receptor (1985) (2)
FIB/STEM Investigation of Four Impact Craters from the Stardust Comet Sample Return Mission Foils (2017) (2)
The separate effects of E60Q in Lactobacillus casei thymidylate synthase delineate between mechanisms for formation of intermediates in catalysis. (1998) (2)
STRUCTURES OF THYMIDYLATE SYNTHASE WITH A C-TERMINAL DELETION: ROLE OF THE C-TERMINUS IN ALIGNMENT OF D/UMP AND CH2H4FOLATE (1993) (1)
Complement and disease. Current concepts. (1967) (1)
Discovery, characterization, and structural determination of a novel UDP‐2,3‐diacylglucosamine hydrolase (2010) (1)
Crystal Structure of the Human Rhesus Glycoprotein RhCG (2009) (1)
Properties of Radiolabeled Rabbit C1q (1973) (1)
crystal structure of RluD from E. coli (2006) (1)
Correlated Microanalysis of Extraterrestrial Carbonaceous Nanoglobules (2009) (1)
Crystal structure of Mycobacterium tuberculosis enoyl reductase (InhA) complexed with 1-cyclohexyl-N-(3,5-dichlorophenyl)-5-oxopyrrolidine-3-carboxamide (2006) (1)
The effect of pre-incubation on trypsin kinetics at low pH. (1977) (1)
On the Structure and Mechanism of Two-Pore Channels (2017) (1)
E. COLI THYMIDYLATE SYNTHASE COMPLEXED WITH DDURD (1998) (1)
Crystal structure of the third KH domain of human Poly(C)-Binding Protein-2 in complex with C-rich strand of human telomeric DNA (2007) (1)
Human Thymidylate Synthase Bound to dUMP and LY231514, a Pyrrolo(2,3-d)pyrimidine-based Antifolate (2001) (1)
Chapter 1:Facing the Wall in Computationally Based Approaches to Drug Discovery (2007) (1)
TRANSMISSION ELECTRON MICROSCOPY OF A PRESOLAR SUPERNOVA HIBONITE GRAIN. (2008) (1)
Caught in Action: X-ray Structure of Thymidylate Synthase with Noncovalent Intermediate Analog. (2021) (1)
Title Cofactor-mediated conformational control in the bifunctional kinase / RNase Ire 1 Permalink (2011) (1)
The crystal structure of colicin IA (1996) (1)
Nitrosomonas europaea Rh50 and mechanism of conduction by Rhesus protein family of channels (2007) (1)
JE-2147-HIV Protease Complex (2002) (1)
Crystal Structure of the Macrocycle-forming Thioesterase Domain of Erythromycin Polyketide Synthase (DEBS TE) (2002) (1)
Integral Membrane Protein Expression in Saccharomyces cerevisiae. (2016) (1)
Isotopically Anomalous Carbonaceous Nanoglobules in Meteorites and Comets (2009) (1)
STRUCTURE OF BOVINE TRYPSINOGEN AT 1.9 ANGSTROMS RESOLUTION (1979) (1)
Present at the flood: How structural biology came about, by Richard E. Dickerson (2006) (1)
CRYSTAL STRUCTURE OF THE E. COLI GLYCEROL FACILITATOR (GLPF) WITHOUT SUBSTRATE GLYCEROL (2002) (1)
Transmission Electron Microscopy of the Bonanza Supernova SiC Grain (2014) (1)
Michael A. Raftery (1936–2007)—the first enzyme mechanism, sequential cooperativity, and the nicotinic acetylcholine receptor defined (2008) (1)
Practical proteins. (1993) (1)
CRYSTAL STRUCTURE OF ESCHERICHIA COLI THYMIDYLATE SYNTHASE (2000) (1)
The role of tryptophan cation–pi interactions on ammonia transport through the AmtB ammonia channel (2007) (1)
Crystal structure of DHFR-TS from Cryptosporidium hominis (2003) (1)
The crystal structure of E. coli Fmu binary complex with S-Adenosylmethionine at 2.1 A resolution (2004) (1)
Structure of a Vesicular Glutamate Transporter Determined by Cryo-Em (2021) (1)
Diversity of function and mechanism in a family of organic anion transporters. (2022) (1)
Structure Inhibition and Regulation of a Two-Pore Channel TPC1 (2017) (1)
Structure-based discovery of a new class of enzyme inhibitors (1996) (1)
Allosteric Inhibition of a Vesicular Glutamate Transporter by an Isoform-Specific Antibody (2021) (1)
RECURRENT MENINGOCOCCAL MENINGITIS AND ABSENCE OF THE SIXTH COMPONENT OF COMPLEMENT (1977) (1)
Vicia faba TPC1, a genetically encoded variant of the vacuole Two Pore Channel 1, is hyperexcitable (2021) (1)
Dose of PTEN Gene Drives Progression of Prostate Cancer (2003) (1)
Discovery of Glassy Carbon in Meteoritic Nanodiamond Residues: Implications for Nanodiamond Origins (2011) (1)
Pre- and post-accretionary carbonates in the Renazzo CR chondrite (2008) (1)
CRYSTAL STRUCTURE OF THYMIDYLATE SYNTHASE FROM T4 PHAGE (1994) (1)
Crystal structure of Mycobacterium tuberculosis enoyl reductase (INHA) complexed with N-(3-bromophenyl)-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide, refined with new ligand restraints (2014) (1)
Terbium‐Calcium Binding Sites on the Acetylcholine Receptor a (1987) (1)
Structural and Chemical Heteorogeneity in the Bonzana Supernova SiC Grain (2015) (1)
A radioimmunoassay for C1 esterase. (1971) (1)
Structural studies of. cap alpha. -bungarotoxin. 1. Sequence-specific /sub 1/H NMR resonance assignments (1988) (0)
E. COLI THYMIDYLATE SYNTHASE IN COMPLEX WITH BW1843U89 AND 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP) (1996) (0)
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Cryo-EM structure of Saccharomyces cerevisiae ER membrane protein complex bound to Fab-DH4 in lipid nanodiscs (2020) (0)
Structural insights into the catalytic mechanism of CD38: Evidence for a conformationally flexible covalent enzyme-substrate complex. (2010) (0)
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X-ray structure of the aquaglyceroporin from Plasmodium falciparum (2008) (0)
Approaches to modeling protein flexibility during drug design (2002) (0)
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Practical Proteins: Protein Structure . New Approaches to Disease and Therapy. Max Perutz. Freeman, New York, 1992. xiv, 326 pp., illus. $44.95 or £33.95; paper, $34.95 or £22.95. (1993) (0)
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Lactobacillus casei thymidylate synthase Y261W-dUMP complex (2006) (0)
CRYSTAL STRUCTURE OF E. COLI THYMIDYLATE SYNTHASE COMPLEXED WITH TOSYL-D-PROLINE (2000) (0)
Chromosome Locus and Candidate Gene for Osteoporosis Identified (2003) (0)
refined protein structures Significance of structural changes in proteins : Expected errors in (2006) (0)
The Role of Detergents and Lipids in Membrane Protein Crystallography (2010) (0)
INSECTICIDAL CRYSTAL PROTEIN CRY2AA (2001) (0)
Nanoglobule Abundances in IOM Extracts: Correlation with Parent Body Processing (2011) (0)
Structure of AtTPC1 D376A (2018) (0)
Saccharomyces cerevisiae lanosterol 14-alpha demethylase with lanosterol bound (2014) (0)
The first ketoreductase of the erythromycin synthase (crystal form 2) (2006) (0)
THYMIDYLATE SYNTHASE R23I MUTANT (2000) (0)
Crystal structure of the catalytic domain of human Pus1 with MES in the active site (2013) (0)
Author response: Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether (2019) (0)
Crystal structure of Enterococcus faecalis Thymidylate synthase. (2010) (0)
E. coli D-galactonate:proton symporter mutant E133Q in the outward substrate-bound form (2019) (0)
Monitoring and Optimizing Detergent Concentration For Membrane Protein Crystallization While Following Protein Homogeneity (2010) (0)
Gene Expression Profile Created for Mouse Stem Cells and Developing Embryo (2003) (0)
E. coli thymidylate synthase mutant I264Am (2018) (0)
New Screen Identifies Elusive MicroRNA Targets (2003) (0)
CRYSTAL STRUCTURE OF THE E. COLI GLYCEROL FACILITATOR (GLPF) MUTATION W48F, F200T (2002) (0)
Crystal Structure of AqpZ mutant L170C (2007) (0)
The structural basis for activation of voltage sensor domains in an ion channel TPC1 (2018) (0)
Faculty Opinions recommendation of Membrane scission by the ESCRT-III complex. (2009) (0)
E. coli D-galactonate:proton symporter in the inward open form (2019) (0)
N AND GTPASE DOMAINS OF THE SIGNAL SEQUENCE RECOGNITION PROTEIN FFH FROM THERMUS AQUATICUS (1999) (0)
Structure of RNaseIIIb and dsRNA binding domains of mouse Dicer (2008) (0)
Structure of the rat vesicular glutamate transporter 2 determined by single particle Cryo-EM (2020) (0)
Electron Microscopy Studies of Comet Wild-2 Particulate Residue Preserved in the Stardust Metallic Foil Craters (2006) (0)
Inhibition of HIF2α Protein Suppresses pVHL-Driven Tumor Growth (2003) (0)
Crystal structure of the heterodimeric ABC transporter TmrAB, a homolog of the antigen translocation complex TAP (2017) (0)
Docking Model for MAT and ACP (2003) (0)
Correlated Microanalysis of Carbonaceous Nanoglobules (2009) (0)
Crystal Structure of AmtB from E.Coli with Methyl Ammonium. (2004) (0)
E. COLI THYMIDYLATE SYNTHASE MUTANT N177A (1999) (0)
THYMIDYLATE SYNTHASE R178T, R179T DOUBLE MUTANT (1998) (0)
Crystal Structure and Metal-Binding Specificity of ZneB, the Periplasmic Adaptor Protein of A Heavy Metal Resistance System from Cupriavidus Metallidurans CH34 (2010) (0)
Structural basis for human claudin‐9 ion selectivity and tight junction dissociation by a bacterial toxin (2019) (0)
TERNARY COMPLEX OF THYMIDYLATE SYNTHASE FROM PNEUMOCYSTIS CARINII (2000) (0)
L. CASEI THYMIDYLATE SYNTHASE MUTANT E60Q TERNARY COMPLEX WITH FDUMP AND CB3717 (1997) (0)
2.5 Angstrom Resolution X-ray Structure of Aquaporin Z (2003) (0)
Crystal structure of the catalytic domain of RluB in complex with a 21-nucleotide RNA substrate (2013) (0)
Exploring Drug Design Methods with Thymidylate Synthase (1998) (0)
E. COLI THYMIDYLATE SYNTHASE IN COMPLEX WITH METHOTREXATE (MTX) AND 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP) (1998) (0)
Crystal structure of human claudin-4 in complex with Clostridium perfringens enterotoxin C-terminal domain (2020) (0)
T Cells from Patients with Neuromyelitis Optica Recognize Discrete T Cell Determinants of Aquaporin-4 and Exhibit a Proinflammatory Th17 Bias (S60.003) (2012) (0)
Crystal structure of an artificial 4-helix bundle protein (1996) (0)
Crystal structure of human thymidylate synthase Y202A in inactive conformation. (2014) (0)
Encoding Selectivity of a Transmembrane Channel (2002) (0)
Structure and dynamics of the essential endogenous mycobacterial polyketide synthase Pks13 (2023) (0)
Crystal structure of pseudoudirinde synthase TruA in complex with leucyl tRNA (2007) (0)
Crystal Structure of E. coli 5-methyluridine methyltransferase RumA in complex with ribosomal RNA substrate and S-adenosylhomocysteine. (2005) (0)
Structure of AtTPC1(DDE) in state 2 (2018) (0)
LACTOBACILLUS CASEI THYMIDYLATE SYNTHASE TERNARY COMPLEX WITH DTMP AND H2FOLATE (1995) (0)
The crystal structure of the E. coli Fmu apoenzyme at 1.65 A resolution (2004) (0)
Correction to “Tandem Facial Amphiphiles for Membrane Protein Stabilization” (2013) (0)
FkbI for Biosynthesis of Methoxymalonyl Extender Unit of Fk520 Polyketide Immunosuppresant (2003) (0)
Crystal structure of E.coli thymidylate synthase with dUMP and the BGC 945 inhibitor (2013) (0)
High-Throughput Nano-Scale Characterization of Membrane Proteins Using Fluorescence-Detection Size-Exclusion Chromatography. (2019) (0)
TRYPSIN-KETO-BABIM-CO+2, PH 8.2 (1998) (0)
THE SIGNAL SEQUENCE BINDING PROTEIN FFH FROM THERMUS AQUATICUS (1999) (0)
E. coli TS complexed with dUMP and inhibitor GA9 (2005) (0)
An archetypal molecular transducer of the nervous system: the acetylcholine receptor. (1987) (0)
CHOLESTEROL ESTERASE FROM BOS TAURUS (1999) (0)
Crystal Structure of RluF in complex with a 22 nucleotide RNA substrate (2009) (0)
Crystal structure of Mycobacterium tuberculosis enoyl reductase (InhA) complexed with 1-cyclohexyl-5-oxo-N-phenylpyrrolidine-3-carboxamide (2006) (0)
E. coli Thymidylate Synthase in a Complex with dUMP and LY338913, A Polyglutamylated Pyrrolo(2,3-d)pyrimidine-based Antifolate (2001) (0)
REVEALING HISTORIES OF NANOSCALE COMPONENTS IN PRIMITIVE PLANETARY MATERIALS WITH HIGH-RESOLUTION ELECTRON AND X-RAY MICROSCOPIES. B. T. De Gre- (2019) (0)
Crystal structure of Mycobacterium tuberculosis enoyl reductase (InhA) complexed with N-(3-chloro-2-methylphenyl)-1-cyclohexyl- 5-oxopyrrolidine-3-carboxamide (2006) (0)
Crystalline arrays of membrane-bound acetylcholine receptor (tubular structures/membrane proteins/electron microscopy/antibody labeling/image processing) (1981) (0)
Crystal structure of AqpZ mutant F43W (2010) (0)
Molecular and Structural Basis Underlying Selective Targeting of Claudins by Clostridium perfringens Enterotoxin in Mammalian Gut (2021) (0)
Designed Helical Protein fusion MBP (2005) (0)
IDENTIFCATION OF CIRCUMSTELLAR MAGNETITE IN THE LAPAZ ICEFIELD 031117 CO3.0 (2015) (0)
Overview of Cytokine Receptors (2010) (0)
Structural basis of chemotherapy resistance mediated by thymidylate synthase (1996) (0)
Crystal Crystal structure and mechanistic basis of a functional homolog of the antigen transporter TAP - eScholarship (2017) (0)
Allosteric peptidic inhibitor of human thymidylate synthase that stabilizes inactive conformation of the enzyme. (2013) (0)
Progress towards the structure of a membrane pore-forming toxin (1996) (0)
Engineering a 30-year-old intracellular channel: Twitching a voltage sensor with a taste of pharmacology (2017) (0)
thymidylate synthase Reversible dissociation and unfolding of the dimeric protein data (2006) (0)
Structure of E. coli 5-Methyluridine Methyltransferase TrmA in complex with 19 nucleotide T-arm analogue (2008) (0)
Structure and Mechanisms of Selectivity Gating, Inhibition and Activation in an Ion Channel (2018) (0)
Crystal structure of the e. coli ammonia channel AMTB complexed with the signal transduction protein GLNK (2006) (0)
Mechanism of a membrane ‘transceptor’: A transporter and a receptor in one (2019) (0)
TRYPSIN-BABIM-SULFATE, PH 5.9 (1998) (0)
CRYSTAL STRUCTURE OF E. COLI THYMIDYLATE SYNTHASE C146S, L143C COVALENTLY MODIFIED AT C143 WITH N-[TOSYL-D-PROLINYL]AMINO-ETHANETHIOL (2000) (0)
Crystal structure of human claudin-9 in complex with Clostridium perfringens entertoxin C-terminal domain in open form (2019) (0)
Structural Basis of Prostaglandin Efflux by MRP4 (2022) (0)
STRUCTURE OF HYDROLASE (SERINE PROTEINASE) (1997) (0)
E. COLI THYMIDYLATE SYNTHASE IN COMPLEX WITH CB3717 (1998) (0)
E. COLI THYMIDYLATE SYNTHASE IN SYMMETRIC COMPLEX WITH CB3717 AND 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP) (1998) (0)
Structure of FTSY:GMPPNP Complex (2007) (0)
34 – Segmental Accommodation: A Novel Conformational Change Induced Upon Ligand Binding by Thymidylate Synthase1 (1990) (0)
Structure of human thymidylate synthase in inactive conformation with a novel non-peptidic inhibitor (2012) (0)
Structures of SRP54 and SRP19, the two proteins assembling the ribonucleic core of the Signal Recognition Particle from the archaeon Pyrococcus furiosus. (2008) (0)
E. COLI THYMIDYLATE SYNTHASE MUTANT E58Q IN COMPLEX WITH CB3717 AND 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP) (1997) (0)
THYMIDYLATE SYNTHASE R179T MUTANT (1998) (0)
Efficiency of Electrical Spin-Injection in GaAs-based Spin Light Emitting Diodes (SpinLEDs) (2001) (0)
Crystal structure of integral membrane protein Aquaporin AqpM at 1.68A resolution (2005) (0)
Structural characterization of the tripartite complex Serinc5-adaptor protein 2-HIV Nef (2022) (0)
High-resolution structures using cryo-EM guide drug development for neuromyelitis optica (NMO). (2023) (0)
Femtosecond nanocrystallography of membrane proteins opens a new era for structural biology (2012) (0)
Crystal structure of Mycobacterium tuberculosis enoyl reductase (InhA) complexed with N-(3-bromophenyl)-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide (2006) (0)
Crystal structure of bovine coupling Factor B bound with cadmium (2008) (0)
L. casei thymidylate synthase Y261A in complex with substrate, dUMP (2006) (0)
Crystal structure of human claudin-9 in complex with Clostridium perfringens entertoxin C-terminal domain in closed form (2019) (0)
THYMIDYLATE SYNTHASE, MUTATION, N229C WITH 2'-DEOXYCYTIDINE 5'-MONOPHOSPHATE (DCMP) (1996) (0)
Efficiencyofsignallingthrough cytokine receptors dependscriticallyon receptororientation (2006) (0)
THYMIDYLATE SYNTHASE R179E MUTANT (1996) (0)
THYMIDYLATE SYNTHASE R178T MUTANT (1998) (0)
E. COLI THYMIDYLATE SYNTHASE (1998) (0)
High resolution structure of Escherichia coli thymidylate synthase ternary complex with dUMP and a cofactor analog, CB3717 (2006) (0)
X-ray crystal structure of a heavy metal efflux pump, crystal form II (2013) (0)
A DESIGNED FOUR HELIX BUNDLE PROTEIN. (1998) (0)
Thymidylate synthase ternary complex with dUMP and CB3717 (2013) (0)
Crystal structure of a key regulator of virulence in Mycobacterium tuberculosis (2011) (0)
Crystal Structure of Ammonia Channel AmtB from E. Coli (2004) (0)
Thioesterase Domain from Picromycin Polyketide Synthase, pH 7.6 (2003) (0)
Structure of Apo FTSY (2007) (0)
D E F I C I E N C Y of C L R I N H U M a N S E R U M Efi~ects on the Structure and Function of Macromolecular Ci* (1969) (0)
TRYPSIN-KETO-BABIM, ZN+2-FREE, PH 8.2 (1998) (0)
Crystal Structure of EcTS W80G/dUMP/CB3717 Complex (2002) (0)
Crystal Structure of KH1 domain of human Poly(C)-binding protein-2 with C-rich strand of human telomeric DNA (2005) (0)
CRYSTAL STRUCTURE OF ISOCITRATE DEHYDROGENASE MUTANT K230M BOUND TO ISOCITRATE AND MN2 (1999) (0)
EssC (ATPases 2 and 3) from Geobacillus thermodenitrificans (SeMet) (2015) (0)
L. CASEI THYMIDYLATE SYNTHASE MUTANT E60Q BINARY COMPLEX WITH FDUMP (1997) (0)
The Channel Architecture and Functional Characterization of Bovine AQP0 (2005) (0)
E. coli TS Complex with dUMP and the Pyrrolo(2,3-d)pyrimidine-based Antifolate LY341770 (2001) (0)
VCX1 Calcium/Proton Exchanger (2013) (0)
Crystal Structure of EcTS/dUMP/THF Complex (2002) (0)
Crystal structure of E. coli Lactose permease G46W/G262W bound to p-nitrophenyl alpha-D-galactopyranoside (alpha-NPG) (2015) (0)
Attachment site(s) of retinal in bacteriorhodopsin (halobacteria/purple membrane/tertiary structure/chromophore/borohydride reduction) (1981) (0)
Structure of AtTPC1(DDE) reconstituted in saposin A with cat06 Fab (2018) (0)
Interface effects in Fe/AlGaAs Schottky barrier spinLEDs (2003) (0)
Model of the Beta-Carbon Processing Enzymes and Acyl Carrier Protein of Modular Polyketide Synthases (2006) (0)
ERYTHROPOIETIN COMPLEXED WITH EXTRACELLULAR DOMAINS OF ERYTHROPOIETIN RECEPTOR (1999) (0)
Crystal structure of aquaporin AqpM at 2.3A resolution (2005) (0)
Further studies on the cleavage of guinea-pig C′2☆☆☆ (1966) (0)
Crystal structure of E. coli lactose permease G46W,G262W bound to sugar (2014) (0)
Human Hsp90 in complex with 17-desmethoxy-17-N,N-Dimethylaminoethylamino-Geldanamycin (2003) (0)
Distinct Mechanisms Control Transposon Inheritance through Overlapping Pathways (2003) (0)
L. CASEI THYMIDYLATE SYNTHASE WITH SPECIES SPECIFIC INHIBITOR (1998) (0)
Structure and dynamics of the essential endogenous mycobacterial polyketide synthase PKs13 by cryogenic electron microscopy. (2023) (0)
Crystal structure of human m1A58 methyltransferase in a complex with tRNA3Lys and SAH (2015) (0)
CRYSTAL STRUCTURE OF E. COLI THYMIDYLATE SYNTHASE COMPLEXED WITH SP-722 (2000) (0)
STRUCTURE OF RAT TRYPSIN (1997) (0)
Crystal structure of HIV-1 integrase catalytic core in complex with Fab (2016) (0)
Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth (2022) (0)
Cytoplasmic domain of the Thermomonospora curvata Type VII Secretion ATPase EccC (2015) (0)
SIV PROTEASE CRYSTALLIZED WITH PEPTIDE PRODUCT (1997) (0)
GAD2 Identified as Candidate Gene for Obesity (2003) (0)
Structure of LpxI D225A mutant (2012) (0)
Human GLUT1 in complex with Cytochalasin B (2016) (0)
THYMIDYLATE SYNTHASE E60D MUTANT BINARY COMPLEX WITH 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP) (1997) (0)
Lactobacillus casei Y261M in complex with substrate, dUMP (2006) (0)
THE CRYSTAL STRUCTURE OF E. COLI PSEUDOURIDINE SYNTHASE I AT 1.5 ANGSTROM RESOLUTION (2000) (0)
LACTOBACILLUS CASEI THYMIDYLATE SYNTHASE TERNARY COMPLEX WITH DUMP AND CB3717 (1995) (0)
Interplanetary dust collected in the comet Grigg-Skjellerup dust stream (2008) (0)
Thermomonospora curvata EccC (ATPases 2 and 3) in complex with a signal sequence peptide (2015) (0)
Designof potent selective zinc-mediatedserine protease inhibitors (0)
CRYSTAL STRUCTURE OF THYMIDYLATE SYNTHASE FROM PNEUMOCYSTIS CARINII BOUND TO DUMP AND BW1843U89 (2001) (0)
Escherichia coli Y209W apoprotein (2006) (0)
Enzymatic and structural studies of UDP‐2,3‐diacylglucosamine hydrolysis in lipid A biosynthesis (2012) (0)
KOLLMAN energy : Alanyl dipeptide as a test case Inclusion of solvation free energy with molecular mechanics (2006) (0)
STRUCTURE OF THYMIDYLATE SYNTHASE (1997) (0)
Structure and dynamics of the essential endogenous mycobacterial polyketide synthase Pks13 (2023) (0)
E. coli thymidylate synthase Y209W variant in complex with substrate and a cofactor analog (2012) (0)
Crystal structure of beta-trypsin in complex with benzamidine (1995) (0)
E. coli Thymidylate Synthase Bound to dUMP and LY338529, A Pyrrolo(2,3-d)pyrimidine-based Antifolate (2001) (0)
Cryptococcus neoformans thymidylate synthase complexed with substrate and an antifolate (2005) (0)
Structure of an asymmetric tetramer of human tRNA m1A58 methyltransferase in a complex with SAH and tRNA3Lys (2015) (0)
Two Mechanisms in One Family: Packaging of Glutamate into Synaptic Vesicles against a Proton Gradient, a Transporter Driven by Membrane Potential, versus a Homolog Driven Downhill with Proton Gradients (2017) (0)
Structure of the signal sequence recognition protein, Ffh (1997) (0)
Two-pore channel 3 (2019) (0)
UNLIGANDED SIV PROTEASE STRUCTURE IN AN ""OPEN"" CONFORMATION (1998) (0)
Escherichia coli thymidylate synthase Y209W in complex with substrate, dUMP, and a cofactor analog, CB3717 (2006) (0)
THYMIDYLATE SYNTHASE R179A MUTANT (1996) (0)
E. coli TSase complex with a bi-substrate reaction intermediate diastereomer analog (2021) (0)
Crystal structure of bovine coupling Factor B bound with phenylarsine oxide (2008) (0)
How do voltage sensors in trans-membrane channels work? (2016) (0)
What the structure of the acetylcholine receptor tells us about function of the ligand gated ion channel family (1990) (0)
Structure of Aquaporin Reveals Mechanism for Transport Selectivity (2003) (0)
E. COLI THYMIDYLATE SYNTHASE IN COMPLEX WITH CB3717 AND 2',5'-DIDEOXYURIDINE (DDURD) (1998) (0)
Lactose permease complex with thiodigalactoside and nanobody 9043 (2020) (0)
Crystal structure of the oligomer formed by the kinase-ribonuclease domain of Ire1 (2008) (0)
Structural Analysis of a Phosphate ‘Transceptor’ (2020) (0)
Peroxisomal fatty-acid transport: structure and function (2022) (0)
Peptitergents: novel peptides capable of solubilizing membrane proteins for crystallization (1996) (0)
THYMIDYLATE SYNTHASE, MUTATION, N229D WITH 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP) (1996) (0)
Crystal structure of bovine coupling Factor B, G28E mutant (2008) (0)
Structure of AtTPC1(DDE) reconstituted in saposin A (2018) (0)
Designofpotentselective zinc-mediatedserine proteaseinhibitors (1998) (0)
LpxI: A Novel Phosphosaccharolipid Hydrolase (2012) (0)
Allosteric Inhibition of a Vesicular Glutamate Transporter by an Isoform-Specific Antibody. (2021) (0)
Crystal structure of the catalytic domain of human Pus1 (2013) (0)
THERMOSTABLE THYMIDYLATE SYNTHASE A FROM BACILLUS SUBTILIS (1999) (0)
Novel Receptor Guides Germ Cell Transepithelial Migration in Drosophila (2003) (0)
A TEM Study of Pristine Matrix from the Tagish Lake Meteorite (2011) (0)

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