Robert MacLaren | Academic Influence

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Robert MacLaren

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#9077

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#12579

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#6073

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#7554

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Philosophy

Robert MacLaren's Degrees

PhD Ophthalmology University of Oxford

Why Is Robert MacLaren Influential?

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According to Wikipedia, Robert E. MacLaren FMedSci FRCOphth FRCS FACS VR is a British ophthalmologist who has led pioneering work in the treatment of blindness caused by diseases of the retina. He is Professor of Ophthalmology at the University of Oxford and Honorary Professor of Ophthalmology at the UCL Institute of Ophthalmology. He is a Consultant Ophthalmologist at the Oxford Eye Hospital. He is also an Honorary Consultant Vitreo-retinal Surgeon at the Moorfields Eye Hospital. MacLaren is an NIHR Senior Investigator, or lead researcher, for the speciality of Ophthalmology. In addition, he is a member of the research committee of Euretina: the European Society of Retina specialists, Fellow of Merton College, in Oxford and a Fellow of the Higher Education Academy.

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Robert MacLaren's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Retinal repair by transplantation of photoreceptor precursors (2006) (853)
Retinal gene therapy in patients with choroideremia: initial findings from a phase 1/2 clinical trial (2014) (697)
Effective gene therapy with nonintegrating lentiviral vectors (2006) (470)
Comprehensive Rare Variant Analysis via Whole-Genome Sequencing to Determine the Molecular Pathology of Inherited Retinal Disease. (2017) (327)
Subretinal Visual Implant Alpha IMS – Clinical trial interim report (2015) (310)
Reversal of end-stage retinal degeneration and restoration of visual function by photoreceptor transplantation (2013) (224)
The drusenlike phenotype in aging Ccl2-knockout mice is caused by an accelerated accumulation of swollen autofluorescent subretinal macrophages. (2009) (194)
Half-Dose Photodynamic Therapy versus High-Density Subthreshold Micropulse Laser Treatment in Patients with Chronic Central Serous Chorioretinopathy: The PLACE Trial. (2018) (169)
Transplanted photoreceptor precursors transfer proteins to host photoreceptors by a mechanism of cytoplasmic fusion (2016) (163)
Pharmacological disruption of the outer limiting membrane leads to increased retinal integration of transplanted photoreceptor precursors (2008) (161)
Immunological Instability of Persistent Adenovirus Vectors in the Brain: Peripheral Exposure to Vector Leads to Renewed Inflammation, Reduced Gene Expression, and Demyelination (1996) (157)
Autologous transplantation of the retinal pigment epithelium and choroid in the treatment of neovascular age-related macular degeneration. (2007) (146)
Interim Results of a Multicenter Trial with the New Electronic Subretinal Implant Alpha AMS in 15 Patients Blind from Inherited Retinal Degenerations (2017) (138)
Long‐Term Survival of Photoreceptors Transplanted into the Adult Murine Neural Retina Requires Immune Modulation (2010) (123)
Function of human pluripotent stem cell-derived photoreceptor progenitors in blind mice (2016) (122)
First-in-human study of the safety and viability of intraocular robotic surgery (2018) (121)
CRISPR-Cas9 DNA Base-Editing and Prime-Editing (2020) (121)
Beneficial effects on vision in patients undergoing retinal gene therapy for choroideremia (2018) (120)
Targeted Disruption of Outer Limiting Membrane Junctional Proteins (Crb1 and ZO-1) Increases Integration of Transplanted Photoreceptor Precursors into the Adult Wild-Type and Degenerating Retina (2010) (119)
Assessment of the Electronic Retinal Implant Alpha AMS in Restoring Vision to Blind Patients with End-Stage Retinitis Pigmentosa (2017) (119)
Retinal stem cell transplantation: Balancing safety and potential (2020) (111)
Biometry and formula accuracy with intraocular lenses used for cataract surgery in extreme hyperopia. (2007) (110)
Two-Year Results After AAV2-Mediated Gene Therapy for Choroideremia: The Alberta Experience. (2018) (110)
Technique of retinal gene therapy: delivery of viral vector into the subretinal space (2017) (108)
Clinical applications of retinal gene therapy (2013) (106)
Visual Acuity after Retinal Gene Therapy for Choroideremia. (2016) (105)
Choroideremia Gene Therapy Phase 2 Clinical Trial: 24-Month Results. (2019) (105)
Rescue of the Stargardt phenotype in Abca4 knockout mice through inhibition of vitamin A dimerization (2015) (104)
Long-term results of submacular surgery combined with macular translocation of the retinal pigment epithelium in neovascular age-related macular degeneration. (2005) (101)
Cell transplantation strategies for retinal repair. (2009) (100)
In contrast to AAV-mediated Cntf expression, AAV-mediated Gdnf expression enhances gene replacement therapy in rodent models of retinal degeneration. (2006) (98)
Initial results from a first-in-human gene therapy trial on X-linked retinitis pigmentosa caused by mutations in RPGR (2020) (94)
Fundus autofluorescence in the Abca4(-/-) mouse model of Stargardt disease--correlation with accumulation of A2E, retinal function, and histology. (2013) (93)
Chronic central serous chorioretinopathy: long-term follow-up and vision-related quality of life (2016) (91)
Stem cell therapy and the retina (2007) (89)
Comparative Analysis of Progenitor Cells Isolated from the Iris, Pars Plana, and Ciliary Body of the Adult Porcine Eye (2007) (88)
Phenotypic Characterization of EIF2AK4 Mutation Carriers in a Large Cohort of Patients Diagnosed Clinically With Pulmonary Arterial Hypertension (2017) (84)
Retinal pigment epithelium defects accelerate photoreceptor degeneration in cell type-specific knockout mouse models of choroideremia. (2010) (84)
Will Nanotechnology Bring New Hope for Gene Delivery? (2017) (83)
Codon-Optimized RPGR Improves Stability and Efficacy of AAV8 Gene Therapy in Two Mouse Models of X-Linked Retinitis Pigmentosa (2017) (82)
Novel gene function revealed by mouse mutagenesis screens for models of age-related disease (2016) (81)
Functional expression of Rab escort protein 1 following AAV2-mediated gene delivery in the retina of choroideremia mice and human cells ex vivo (2013) (79)
Gene therapy for retinal disease. (2013) (73)
Recessive mutations in TSPAN12 cause retinal dysplasia and severe familial exudative vitreoretinopathy (FEVR). (2012) (72)
The Spectrum of CHM Gene Mutations in Choroideremia and Their Relationship to Clinical Phenotype (2016) (71)
Outcomes of phacoemulsification and intraocular lens implantation in microphthalmos and nanophthalmos (2013) (70)
Correlation of Optical Coherence Tomography and Autofluorescence in the Outer Retina and Choroid of Patients With Choroideremia (2016) (68)
Characterizing the Natural History of Visual Function in Choroideremia Using Microperimetry and Multimodal Retinal Imaging (2017) (68)
 Adeno-associated Virus (AAV) Dual Vector Strategies for Gene Therapy Encoding Large Transgenes (2017) (67)
CNTF Gene Therapy Confers Lifelong Neuroprotection in a Mouse Model of Human Retinitis Pigmentosa. (2015) (66)
ADVIRC is caused by distinct mutations in BEST1 that alter pre-mRNA splicing (2008) (62)
An AAV Dual Vector Strategy Ameliorates the Stargardt Phenotype in Adult Abca4-/- Mice. (2019) (61)
Optimization of in vivo confocal autofluorescence imaging of the ocular fundus in mice and its application to models of human retinal degeneration. (2012) (61)
EIAV vector-mediated delivery of endostatin or angiostatin inhibits angiogenesis and vascular hyperpermeability in experimental CNV (2006) (60)
Gene Therapy and Stem Cell Transplantation in Retinal Disease: The New Frontier. (2016) (59)
Implantation of the black diaphragm intraocular lens in congenital and traumatic aniridia. (2008) (59)
Differential Modulation of Retinal Degeneration by Ccl2 and Cx3cr1 Chemokine Signalling (2012) (58)
Retinal gene therapy in X-linked retinitis pigmentosa caused by mutations in RPGR: Results at 6 months in a first in human clinical trial (2020) (57)
Long‐term visual and microperimetry outcomes following autologous retinal pigment epithelium choroid graft for neovascular age‐related macular degeneration (2008) (56)
Detailed Clinical Phenotype and Molecular Genetic Findings in CLN3-Associated Isolated Retinal Degeneration (2017) (56)
A Qualitative and Quantitative Assessment of Fundus Autofluorescence Patterns in Patients With Choroideremia (2016) (56)
Stem cells as a therapeutic tool for the blind: biology and future prospects (2011) (55)
Gene therapy for choroideremia using an adeno-associated viral (AAV) vector. (2015) (55)
Long-term restoration of visual function in end-stage retinal degeneration using subretinal human melanopsin gene therapy (2017) (54)
Development and role of retinal glia in regeneration of ganglion cells following retinal injury. (1996) (52)
Tropism of engineered and evolved recombinant AAV serotypes in the rd1 mouse and ex vivo primate retina (2017) (52)
Efficacy and Safety of Retinal Gene Therapy Using Adeno-Associated Virus Vector for Patients With Choroideremia: A Randomized Clinical Trial. (2019) (52)
Subretinal delivery of adeno-associated virus serotype 2 results in minimal immune responses that allow repeat vector administration in immunocompetent mice (2009) (52)
Variations in opsin coding sequences cause x-linked cone dysfunction syndrome with myopia and dichromacy. (2013) (51)
Translating induced pluripotent stem cells from bench to bedside: application to retinal diseases. (2013) (51)
Measurement and Reproducibility of Preserved Ellipsoid Zone Area and Preserved Retinal Pigment Epithelium Area in Eyes With Choroideremia. (2017) (50)
Pilot randomised controlled trial of face-down positioning following macular hole surgery (2012) (50)
A genetic case-control study confirms the implication of SMAD7 and TNF locus in the development of proliferative vitreoretinopathy. (2013) (47)
Evaluation of an Optimized Injection System for Retinal Gene Therapy in Human Patients. (2014) (46)
The p53 codon 72 polymorphism (rs1042522) is associated with proliferative vitreoretinopathy: the Retina 4 Project. (2013) (44)
Sources of retinal pigment epithelium (RPE) for replacement therapy (2010) (44)
RNA Editing as a Therapeutic Approach for Retinal Gene Therapy Requiring Long Coding Sequences (2020) (44)
Biometry accuracy using zero‐ and negative‐powered intraocular lenses (2005) (43)
Induced pluripotent stem cell therapies for retinal disease (2010) (43)
Recent advances and future prospects in choroideremia (2015) (43)
Manipulation of the Recipient Retinal Environment by Ectopic Expression of Neurotrophic Growth Factors Can Improve Transplanted Photoreceptor Integration and Survival (2012) (42)
Comparing half-dose photodynamic therapy with high-density subthreshold micropulse laser treatment in patients with chronic central serous chorioretinopathy (the PLACE trial): study protocol for a randomized controlled trial (2015) (41)
Focal and diffuse chronic central serous chorioretinopathy treated with half-dose photodynamic therapy or subthreshold micropulse laser. (2019) (41)
Correlation of retinal structure and function in choroideremia carriers. (2015) (41)
Inclusion of the Woodchuck Hepatitis Virus Posttranscriptional Regulatory Element Enhances AAV2-Driven Transduction of Mouse and Human Retina (2016) (40)
Assessment of Tropism and Effectiveness of New Primate-Derived Hybrid Recombinant AAV Serotypes in the Mouse and Primate Retina (2013) (40)
Non‐viral retinal gene therapy: a review (2012) (40)
The T309G MDM2 Gene Polymorphism Is a Novel Risk Factor for Proliferative Vitreoretinopathy (2013) (38)
CNTF gene transfer protects ganglion cells in rat retinae undergoing focal injury and branch vessel occlusion. (2006) (38)
Monoallelic ABCA4 Mutations Appear Insufficient to Cause Retinopathy: A Quantitative Autofluorescence Study. (2015) (38)
CHANGES IN RETINAL SENSITIVITY AFTER GENE THERAPY IN CHOROIDEREMIA. (2018) (38)
Genome-wide association study identifies genetic risk underlying primary rhegmatogenous retinal detachment. (2013) (38)
Macular function assessed by microperimetry in patients with enhanced S-cone syndrome. (2010) (36)
Isoforms of Melanopsin Mediate Different Behavioral Responses to Light (2015) (35)
Pathogenic mechanisms and the prospect of gene therapy for choroideremia (2015) (34)
Structural and Functional Recovery Following Limited Iatrogenic Macular Detachment for Retinal Gene Therapy (2017) (33)
Surgical Technique for Subretinal Gene Therapy in Humans with Inherited Retinal Degeneration. (2019) (32)
Antisense oligonucleotide therapeutics in clinical trials for the treatment of inherited retinal diseases (2020) (32)
Leber Congenital Amaurosis Associated with AIPL1: Challenges in Ascribing Disease Causation, Clinical Findings, and Implications for Gene Therapy (2012) (32)
Exploring the Variable Phenotypes of RPGR Carrier Females in Assessing Their Potential for Retinal Gene Therapy (2018) (30)
Molecular Strategies for RPGR Gene Therapy (2019) (30)
Gene therapy for the treatment of X-linked retinitis pigmentosa (2018) (30)
Assessment of cone survival in response to CNTF, GDNF, and VEGF165b in a novel ex vivo model of end-stage retinitis pigmentosa. (2011) (30)
Clinical and Molecular Characterization of PROM1-Related Retinal Degeneration (2019) (29)
Optogenetic Gene Therapy for the Degenerate Retina: Recent Advances (2020) (29)
Non-Image-Forming Light Driven Functions Are Preserved in a Mouse Model of Autosomal Dominant Optic Atrophy (2013) (29)
A Critical Period for Axon Regrowth Through a Lesion in the Developing Mammalian Retina (1995) (27)
Retinal Degeneration in Choroideremia follows an Exponential Decay Function. (2018) (27)
VASCULAR ALTERATIONS REVEALED WITH OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN PATIENTS WITH CHOROIDEREMIA. (2019) (26)
Neuroprotective gene therapy for the treatment of inherited retinal degeneration. (2007) (25)
Absence of Neuroplastin-65 Affects Synaptogenesis in Mouse Inner Hair Cells and Causes Profound Hearing Loss (2016) (25)
Choroideremia: molecular mechanisms and development of AAV gene therapy (2018) (25)
Implantation, removal and replacement of subretinal electronic implants for restoration of vision in patients with retinitis pigmentosa (2018) (25)
Single residue AAV capsid mutation improves transduction of photoreceptors in the Abca4-/- mouse and bipolar cells in the rd1 mouse and human retina ex-vivo (2016) (25)
Specific deficits in visual electrophysiology in a mouse model of dominant optic atrophy. (2011) (25)
Macular hole surgery in patients with end-stage choroideremia. (2013) (24)
Monitoring progression of retinitis pigmentosa: current recommendations and recent advances (2020) (24)
Quantitative assessment of barriers to the clinical development and adoption of cellular therapies: A pilot study (2014) (24)
Near-Infrared Autofluorescence in Choroideremia: Anatomic and Functional Correlations. (2017) (23)
Vesicular stomatitis virus glycoprotein- and Venezuelan equine encephalitis virus-derived glycoprotein-pseudotyped lentivirus vectors differentially transduce corneal endothelium, trabecular meshwork, and human photoreceptors. (2014) (23)
Selective Automated Perimetry Under Photopic, Mesopic, and Scotopic Conditions: Detection Mechanisms and Testing Strategies (2016) (23)
Outcome Measures Used in Ocular Gene Therapy Trials: A Scoping Review of Current Practice (2019) (22)
An Economic Evaluation of Voretigene Neparvovec for the Treatment of Biallelic RPE65-Mediated Inherited Retinal Dystrophies in the UK (2020) (22)
Expression of myelin proteins in the opossum optic nerve: Late appearance of inhibitors implicates an earlier non‐myelin factor in preventing ganglion cell regeneration (1996) (20)
Functional Defects in Color Vision in Patients With Choroideremia. (2014) (20)
Predicting proliferative vitreoretinopathy: temporal and external validation of models based on genetic and clinical variables (2014) (20)
Enhancement of Adeno-Associated Virus-Mediated Gene Therapy Using Hydroxychloroquine in Murine and Human Tissues (2019) (20)
Transcorneal electrical stimulation for the treatment of retinitis pigmentosa: results from the TESOLAUK trial (2016) (20)
Human Retinal Explant Culture for Ex Vivo Validation of AAV Gene Therapy. (2018) (20)
An analysis of retinal gene therapy clinical trials. (2009) (19)
Functional expression of complement factor I following AAV-mediated gene delivery in the retina of mice and human cells (2021) (19)
X-linked cone dystrophy and colour vision deficiency arising from a missense mutation in a hybrid L/M cone opsin gene (2013) (19)
AAV-mediated gene transfer of human X-linked inhibitor of apoptosis protects against oxidative cell death in human RPE cells. (2011) (19)
Regeneration and transplantation of the optic nerve: developing a clinical strategy (1998) (19)
Analysis of Pathogenic Variants Correctable With CRISPR Base Editing Among Patients With Recessive Inherited Retinal Degeneration. (2021) (19)
Responsiveness of choroidal neovascular membranes in patients with R345W mutation in fibulin 3 (Doyne honeycomb retinal dystrophy) to anti-vascular endothelial growth factor therapy. (2011) (18)
Repair of Retinal Degeneration following Ex Vivo Minicircle DNA Gene Therapy and Transplantation of Corrected Photoreceptor Progenitors. (2020) (18)
 Regulatory Considerations for Gene Therapy Products in the US, EU, and Japan  (2017) (18)
BAX and BCL‐2 polymorphisms, as predictors of proliferative vitreoretinopathy development in patients suffering retinal detachment: the Retina 4 project (2015) (18)
 The Application of CRISPR/Cas9 for the Treatment of Retinal Diseases  (2017) (18)
A splice-site variant in FLVCR1 produces retinitis pigmentosa without posterior column ataxia (2018) (17)
High Symmetry of Visual Acuity and Visual Fields in RPGR-Linked Retinitis Pigmentosa. (2017) (17)
Immunomodulatory Effects of Hydroxychloroquine and Chloroquine in Viral Infections and Their Potential Application in Retinal Gene Therapy (2020) (17)
[Gene therapy for retinal dystrophies]. (2012) (17)
Insights on the Regeneration Potential of Müller Glia in the Mammalian Retina (2021) (17)
Differential roles for cryptochromes in the mammalian retinal clock (2018) (17)
CRISPR Interference–Potential Application in Retinal Disease (2020) (16)
Stem Cell Treatment for Age-Related Macular Degeneration: the Challenges. (2018) (16)
Cross-over to photodynamic therapy or micropulse laser after failure of primary treatment of chronic central serous chorioretinopathy. (2020) (16)
Regeneration in the developing optic nerve: Correlating observations in the opossum to other mammalian systems (1997) (15)
HYPERREFLECTIVE FOCI AS A PATHOGENETIC BIOMARKER IN CHOROIDEREMIA. (2019) (15)
The Location of Exon 4 Mutations in RP1 Raises Challenges for Genetic Counseling and Gene Therapy. (2019) (15)
Scleral punch method with topical mitomycin c for safe revision of failed deep sclerectomy in nanophthalmic uveal effusion syndrome (2009) (15)
Genome-Editing Strategies for Treating Human Retinal Degenerations (2020) (15)
Real-world refractive outcomes of toric intraocular lens implantation in a United Kingdom National Health Service setting (2018) (15)
Use of an accident and emergency department observation ward in the management of head injury (1993) (15)
RHOQ is induced by DLL4 and regulates angiogenesis by determining the intracellular route of the Notch intracellular domain (2020) (15)
Next generation sequencing using phenotype-based panels for genetic testing in inherited retinal diseases (2020) (14)
Structural Insights into the Unique Activation Mechanisms of a Non-classical Calpain and Its Disease-Causing Variants (2020) (14)
Transcorneal Electrical Stimulation for the Treatment of Retinitis Pigmentosa: A Multicenter Safety Study of the OkuStim® System (TESOLA-Study) (2019) (14)
Optimisation of dark adaptation time required for mesopic microperimetry (2018) (14)
Isolation and characterisation of neural progenitor cells from the adult Chx10 orJ/orJ central neural retina (2008) (13)
Low luminance visual acuity as a clinical measure and clinical trial outcome measure: a scoping review (2021) (13)
Two Novel CAPN5 Variants Associated with Mild and Severe Autosomal Dominant Neovascular Inflammatory Vitreoretinopathy Phenotypes (2019) (13)
The nanophthalmos protein TMEM98 inhibits MYRF self-cleavage and is required for eye size specification (2019) (13)
The Biological Activity of AAV Vectors for Choroideremia Gene Therapy Can Be Measured by In Vitro Prenylation of RAB6A (2018) (13)
A Specific Macula-Predominant Retinal Phenotype Is Associated With the CDHR1 Variant c.783G>A, a Silent Mutation Leading to In-Frame Exon Skipping. (2019) (13)
Hypotrichosis and juvenile macular dystrophy caused by CDH3 mutation: A candidate disease for retinal gene therapy (2016) (13)
Highest reported visual acuity after electronic retinal implantation (2020) (13)
Association of Clinical and Genetic Heterogeneity With BEST1 Sequence Variations. (2020) (13)
Chiasmatic Specificity in the Regenerating Mammalian Optic Nerve (1997) (13)
Molecular Therapies for Choroideremia (2019) (13)
Mouse slc9a8 mutants exhibit retinal defects due to retinal pigmented epithelium dysfunction. (2015) (13)
Patient characteristics of untreated chronic central serous chorioretinopathy patients with focal versus diffuse leakage (2019) (13)
A quantitative, multi-national and multi-stakeholder assessment of barriers to the adoption of cell therapies (2017) (12)
Skull X-ray after head injury: the recommendations of the Royal College of Surgeons Working Party report in practice. (1993) (12)
Mirtron-mediated RNA knockdown/replacement therapy for the treatment of dominant retinitis pigmentosa (2021) (12)
Limitations in Clinical Translation of Nanoparticle-Based Gene Therapy. (2017) (12)
Ocular gene therapy for choroideremia: clinical trials and future perspectives (2018) (12)
Characterization of a dominant cone degeneration in a green fluorescent protein-reporter mouse with disruption of Loci associated with human dominant retinal dystrophy. (2011) (12)
Unilateral pigmentary retinopathy: a retrospective case series (2018) (12)
Test‐retest repeatability of microperimetry in patients with retinitis pigmentosa caused by mutations in RPGR (2020) (11)
Association of Messenger RNA Level With Phenotype in Patients With Choroideremia: Potential Implications for Gene Therapy Dose. (2019) (11)
Therapy Approaches for Stargardt Disease (2021) (11)
Macular spatial distribution of preserved autofluorescence in patients with choroideremia (2018) (11)
RPGR-Related X-Linked Retinitis Pigmentosa Carriers with a Severe “Male Pattern” (2020) (11)
Variable phenotypes in patients diagnosed with idiopathic multifocal choroiditis (2006) (11)
Effect of AAV-mediated rhodopsin gene augmentation on retinal degeneration caused by the dominant P23H rhodopsin mutation in a knock-in murine model. (2020) (11)
First-In-Human Robot-Assisted Subretinal Drug Delivery Under Local Anaesthesia A Randomised Clinical Trial. (2021) (10)
Filtration of Short-Wavelength Light Provides Therapeutic Benefit in Retinitis Pigmentosa Caused by a Common Rhodopsin Mutation. (2019) (10)
Cell fusion following photoreceptor transplantation into the non-degenerate retina (2014) (10)
Re-establishment of visual circuitry after optic nerve regeneration (1999) (10)
Reduced vessel density in deep capillary plexus correlates with retinal layer thickness in choroideremia (2020) (10)
Potential lifetime quality of life benefits of choroideremia gene therapy: projections from a clinically informed decision model (2019) (10)
Electronic retinal implant surgery (2017) (10)
Peripapillary Sparing in Autosomal Recessive Bestrophinopathy. (2020) (10)
Olfactory Dysfunction in Patients With CNGB1-Associated Retinitis Pigmentosa (2018) (9)
Impact of Vital Dyes on Cell Viability and Transduction Efficiency of AAV Vectors Used in Retinal Gene Therapy Surgery: An In Vitro and In Vivo Analysis (2017) (9)
A clinical-grade gene therapy vector for pharmacoresistant epilepsy successfully overexpresses NPY in a human neuronal cell line (2017) (9)
Adeno-Associated Viral Gene Therapy for Retinal Disorders (2015) (9)
RPGR gene therapy presents challenges in cloning the coding sequence (2020) (9)
Inclusion of PF68 Surfactant Improves Stability of rAAV Titer when Passed through a Surgical Device Used in Retinal Gene Therapy (2019) (9)
Combining M-FISH and Quantum Dot technology for fast chromosomal assignment of transgenic insertions (2011) (9)
Progress in the development of novel therapies for choroideremia (2019) (9)
ON-bipolar cell gene expression during retinal degeneration: Implications for optogenetic visual restoration (2021) (9)
Changes in microchip position after implantation of a subretinal vision prosthesis in humans (2018) (9)
Long‐term follow‐up of chronic central serous chorioretinopathy after successful treatment with photodynamic therapy or micropulse laser (2021) (9)
Effects of pupil dilation on MAIA microperimetry (2017) (8)
Assessment of AAV Dual Vector Safety in the Abca4−/− Mouse Model of Stargardt Disease (2020) (8)
Association of a Novel Intronic Variant in RPGR With Hypomorphic Phenotype of X-Linked Retinitis Pigmentosa. (2020) (8)
Reply to Comment on: Focal and Diffuse Chronic Central Serous Chorioretinopathy Treated With Half-Dose Photodynamic Therapy or Subthreshold Micropulse Laser: PLACE Trial Report No. 3 (2020) (8)
AAV2/8 Anti-angiogenic Gene Therapy Using Single-Chain Antibodies Inhibits Murine Choroidal Neovascularization (2018) (8)
Improved mobility with depth-based residual vision glasses (2014) (8)
Gene Therapy for Retinal Disease: What Lies Ahead (2015) (8)
Cone photoreceptor neuroprotection conferred by CNTF in a novel in vivo model of battlefield retinal laser injury. (2013) (8)
 Gene Therapy for Color Blindness (2017) (8)
Intracranial plasmacytoma masquerading as Gradenigo’s syndrome (1998) (8)
A fragmented adeno-associated viral dual vector strategy for treatment of diseases caused by mutations in large genes leads to expression of hybrid transcripts. (2016) (8)
Microperimetry Hill of Vision and Volumetric Measures of Retinal Sensitivity (2021) (8)
Focus on molecules: neural retina leucine zipper (NRL). (2012) (8)
Bioengineering strategies for restoring vision (2022) (8)
A Novel Method for Quantitative Serial Autofluorescence Analysis in Retinitis Pigmentosa Using Image Characteristics (2016) (7)
Reply: Cataract surgery and microphthalmic eyes. (2013) (7)
Cone fusion confusion in photoreceptor transplantation. (2017) (7)
Retinal cadherins and the retinal cadherinopathies: Current concepts and future directions (2022) (7)
Characterizing the cellular immune response to subretinal AAV gene therapy in the murine retina (2021) (7)
Robot-Assisted Retinal Surgery: Overcoming Human Limitations (2019) (7)
Chimeric human opsins as optogenetic light sensitisers (2018) (7)
Early Cone Photoreceptor Outer Segment Length Shortening in RPGR X-Linked Retinitis Pigmentosa (2020) (7)
CRISPR genome engineering for retinal diseases. (2021) (7)
Clinical Characterization of Retinitis Pigmentosa Associated With Variants in SNRNP200. (2019) (7)
Crossover to Photodynamic Therapy or Micropulse Laser After Failure of Primary Treatment of Chronic Central Serous Chorioretinopathy: The REPLACE Trial (2021) (7)
Retinal Gene Therapy for Choroideremia in a Multicenter Dose Escalation Phase I/II Clinical Trial (2018) (6)
“Genetic and clinical findings in an ethnically diverse retinitis pigmentosa cohort associated with pathogenic variants in EYS” (2020) (6)
Vector Shedding and Immunogenicity Sampling for Retinal Gene Therapy. (2018) (6)
Inner retinal thickening affects microperimetry thresholds in the presence of photoreceptor thinning in patients with RPGR retinitis pigmentosa (2020) (6)
A novel homozygous c.67C>T variant in retinol binding protein 4 (RBP4) associated with retinitis pigmentosa and childhood acne vulgaris (2020) (6)
Novel non‐contiguous exon duplication in choroideremia (2018) (6)
Prevalence and phenotype associations of complement factor I mutations in geographic atrophy (2021) (6)
Validation of electronic visual acuity (EVA) measurement against standardised ETDRS charts in patients with visual field loss from inherited retinal degenerations (2019) (6)
AAV Induced Expression of Human Rod and Cone Opsin in Bipolar Cells of a Mouse Model of Retinal Degeneration (2021) (6)
Natural History of Progression of Choroideremia (NIGHT) Study: Cross-Sectional Analysis of Baseline Characteristics (2018) (5)
Endothelial dysfunction in pulmonary hypertension (2010) (5)
A detailed in vivo analysis of the retinal nerve fibre layer in choroideremia (2019) (5)
Outcome of Full-Thickness Macular Hole Surgery in Choroideremia (2017) (5)
Submacular Surgery: Author Reply (2006) (5)
Uveitic Glaucoma and Rosai-Dorfman Disease (Sinus Histiocytosis) (2006) (5)
CRISPR Systems Suitable for Single AAV Vector Delivery. (2021) (5)
A distinct retinal pigment epithelial cell autofluorescence pattern in choroideremia predicts early involvement of overlying photoreceptors (2019) (5)
Misdiagnosis of X-linked retinitis pigmentosa in a choroideremia patient with heavily pigmented fundi (2018) (5)
Low-contrast visual acuity versus low-luminance visual acuity in choroideremia. (2020) (5)
Gene therapy for inherited retinal disease: long-term durability of effect. (2022) (5)
Benefits of gene therapy for both eyes (2016) (4)
Emerging In Vitro 3D Tumour Models in Nanoparticle-Based Gene and Drug Therapy. (2018) (4)
Tetradecanoylphorbol-13-acetate (TPA) significantly increases AAV2/5 transduction of human neuronal cells in vitro. (2012) (4)
Outcomes following cataract surgery in choroideremia (2015) (4)
A novel mutation in the dominantly inherited TOPORS gene supports haploinsufficiency as the mechanism of retinitis pigmentosa (2017) (4)
Reply to: Comment on: PLACE Trial Report No. 3. (2020) (4)
North Carolina macular dystrophy shows a particular drusen phenotype and atrophy progression (2021) (4)
Presence of corneal crystals confirms an unusual presentation of Bietti’s retinal dystrophy (2019) (4)
A first-in-man trial assessing robotic surgery inside the human eye to perform a subretinal injection (2018) (4)
Electrophysiological verification of enhanced S-cone syndrome caused by a novel c.755T>C NR2E3 missense variant (2018) (4)
A glial palisade delineates the ipsilateral optic projection in Monodelphis (1998) (4)
Juxtafoveal Telangiectasias. Authors' reply (2008) (4)
Structural and Functional Characteristics of Color Vision Changes in Choroideremia (2021) (4)
The Natural History of the Progression of Choroideremia (NIGHT) Study: Longitudinal Changes in Visual Acuity over 12 Months (2018) (4)
Genetic and Clinical Findings in an Ethnically Diverse Cohort with Retinitis Pigmentosa Associated with Pathogenic Variants in CERKL (2020) (3)
Analysis of Early Cone Dysfunction in an In Vivo Model of Rod-Cone Dystrophy (2020) (3)
Optical Coherence Tomography in Patients With the Subretinal Implant Retina Implant Alpha IMS. (2017) (3)
Non-Viral Delivery of CRISPR/Cas Cargo to the Retina Using Nanoparticles: Current Possibilities, Challenges, and Limitations (2022) (3)
Gene therapy for age-related macular degeneration (2015) (3)
A Novel Achromatopsia Mouse Model Resulting From a Naturally Occurring Missense Change in Cngb3. (2018) (3)
Deep phenotyping of the Cdhr1-/- mouse validates its use in pre-clinical studies for human CDHR1-associated retinal degeneration. (2021) (3)
Promoter Orientation within an AAV-CRISPR Vector Affects Cas9 Expression and Gene Editing Efficiency. (2020) (3)
Slowly progressive retinitis pigmentosa caused by two novel mutations in the MAK gene (2018) (3)
Enhanced autofluorescence ring findings in RPGR-associated retinitis pigmentosa (2019) (3)
A Quantitative Chloride Channel Conductance Assay for Efficacy Testing of AAV.BEST1. (2019) (3)
Outcome of half-dose photodynamic therapy in chronic central serous chorioretinopathy with fovea-involving atrophy (2020) (3)
Clinical applications of microperimetry in RPGR‐related retinitis pigmentosa: a review (2021) (3)
Correcting visual loss by genetics and prosthetics. (2020) (3)
CDHR1-related late-onset macular dystrophy: further insights (2020) (3)
In Silico Analysis of Pathogenic CRB1 Single Nucleotide Variants and Their Amenability to Base Editing as a Potential Lead for Therapeutic Intervention (2021) (3)
An analysis of the Kozak consensus in retinal genes and its relevance to gene therapy (2021) (3)
CRISPR DNA Base Editing Strategies for Treating Retinitis Pigmentosa Caused by Mutations in Rhodopsin (2022) (3)
Dynamic in vivo quantification of rod photoreceptor degeneration using fluorescent reporter mouse models of retinitis pigmentosa. (2019) (3)
Arterial occlusion after scleral buckling (2008) (2)
Impaired glutamylation of RPGRORF15 underlies the cone-dominated phenotype associated with truncating distal ORF15 variants (2022) (2)
The Impact of Progressive Visual Field Constriction on Reading Ability in an Inherited Retinal Degeneration (2019) (2)
RESPONSE OF CHOROIDAL ABNORMALITIES TO PHOTODYNAMIC THERAPY VERSUS MICROPULSE LASER IN CHRONIC CENTRAL SEROUS CHORIORETINOPATHY (2021) (2)
Natural History of the Progression of RPGR-Associated X-Linked Retinitis Pigmentosa (XOLARIS) Study: Cross-Sectional Analysis of Baseline Characteristics (2019) (2)
Accurate Quantification of AAV Vector Genomes by Quantitative PCR (2021) (2)
A Randomized Crossover Study to Assess the Usability of Two New Vision Tests in Patients with Low Vision. (2019) (2)
The Scope of Pathogenic ABCA4 Mutations Targetable by CRISPR DNA Base Editing Systems—A Systematic Review (2022) (2)
Results from the first use of a robot to operate inside the human eye (2017) (2)
Changes in Retinal Sensitivity Associated With Cotoretigene Toliparvovec in X-Linked Retinitis Pigmentosa With RPGR Gene Variations (2023) (2)
Risks of gene therapy should be weighed against lack of alternatives for many diseases (2005) (2)
A low-cost telescope for enhanced stimulus visual field coverage in functional MRI (2020) (2)
Successful Transplantation of Photoreceptors into the Retina of an Adult Mouse Model of Human Retinitis Pigmentosa (2006) (2)
Stickler syndrome. (2008) (2)
Novel non-sense mutation in RP2 (c.843_844insT/p.Arg282fs) is associated with a severe phenotype of retinitis pigmentosa without evidence of primary retinal pigment epithelium involvement (2019) (2)
Unsutured phakic implantation of a black intraocular lens in the sulcus to treat leukocoria (2014) (2)
Low Luminance Visual Acuity and Low Luminance Deficit in Choroideremia and RPGR-Associated Retinitis Pigmentosa (2021) (2)
A Novel Achromatopsia Mouse Model Resulting From a Naturally Occurring Missense Change in Cngb3. (2018) (2)
A novel splice-site variant in CDH23 in a patient with Usher syndrome type 1 (2019) (2)
Atypical choroideremia presenting with early‐onset macular atrophy (2019) (2)
Beyond the average threshold: Alternatives in the analysis of microperimetry data (2018) (2)
Emerging gene therapy products for RPGR-associated X-linked retinitis pigmentosa (2022) (2)
Tropism of AAV Vectors in Photoreceptor-Like Cells of Human iPSC-Derived Retinal Organoids (2022) (2)
Refractive outcomes with toric intraocular lens implants. (2014) (1)
Pathological donor splice site mutations beyond the dinucleotide canonical sequence in choroideremia (2018) (1)
Choroidal new vessels in type 1 myotonic dystrophy-related macular dystrophy respond to anti-VEGF therapy (2012) (1)
MERTK missense variants in three patients with retinitis pigmentosa (2022) (1)
Combined phacoemulsification and removal of gas following macular hole surgery (2011) (1)
EFFICACY OF HALF-DOSE PHOTODYNAMIC THERAPY VERSUS HIGH-DENSITY SUBTHRESHOLD MICROPULSE LASER FOR TREATING PIGMENT EPITHELIAL DETACHMENTS IN CHRONIC CENTRAL SEROUS CHORIORETINOPATHY (2021) (1)
Publisher Correction: Whole-genome sequencing of a sporadic primary immunodeficiency cohort (2020) (1)
The Effect of Cataract on Color Vision Measurement with the Low-Vision Cambridge Colour Test (2022) (1)
School exam results matter in medical job applications (2004) (1)
Correlation of retinal sensitivity with the area of normal auto-fluorescence in choroideremia patients (2013) (1)
The spectrum of RP1 mutations confirms a dominant negative disease mechanism (2018) (1)
Benign idiopathic haemorrhagic retinotherapy (2002) (1)
RPE degeneration precedes photoreceptor and choroidal loss in choroideremia based on enhanced-depth OCT and fundus autofluorescence correlations (2016) (1)
A Semiautomated, Phenotypic, In Vitro Scratch Assay for Assessing Retinal Pigment Epithelial Cell Wound Healing. (2020) (1)
Improved visual function in patients with choroideremia undergoing subretinal gene therapy (2014) (1)
Longitudinal Study to Assess the Quantitative Use of Fundus Autofluorescence for Monitoring Disease Progression in Choroideremia (2021) (1)
Quantification of Fluorescence in Retinal Sections by Confocal Microscopy following Reporter Gene Delivery (2016) (1)
Long term vision results following retinal gene therapy for choroideremia (2016) (1)
Visual outcome in 26 blind retinitis pigmentosa patients after implantation of subretinal Alpha-IMS devices (2014) (1)
Photoreceptor precursor transplantation leads to exchange of cellular contents between the donor and host retina (2016) (1)
Identification of a new Kozak consensus in genes expressed in photoreceptors. (2019) (1)
Characterisation of Scotopic Vision in Patients with Choroideremia Utilising full-field stimulus threshold (FST) (2016) (1)
Chronic untreated retinal detachment in a patient with choroideremia provides insight into the disease process and potential therapy (2021) (1)
Fundus Autofluorescence in the Abca 4-/-Mouse Model of Stargardt Disease – Correlation with Accumulation of A 2 E , Retinal Function and Histology-Supplementary figures and tables - (2013) (1)
Analysis of cytoplasmic transfer consistent with donor-host cell fusion following photoreceptor transplantation (2016) (1)
Minicircle Delivery to the Neural Retina as a Gene Therapy Approach (2022) (1)
Second trimester low‐lying placenta: Risk for vasa previa (2000) (1)
C20-D3-Vitamin A (ALK-001) rescues the phenotype of an Abca4−/− mouse model of Stargardt disease (2014) (1)
Expression of Rab Prenylation Pathway Genes and Relation to Disease Progression in Choroideremia (2021) (1)
Correlation of distinct fundus autofluorescence features with disruption of the overlying ellipsoid zone in choroideremia (2019) (1)
Retina Fundus Autofluorescence in the Abca 4 / Mouse Model of Stargardt Disease — Correlation With Accumulation of A 2 E , Retinal Function , and Histology (2013) (1)
Comment on: ‘Sector retinitis pigmentosa caused by mutations of the RHO gene’ (2019) (1)
Developing an AAV dual vector ABCA4 gene therapy treatment for Stargardt disease (2014) (1)
Enhanced Integration of Transplanted Photoreceptor Precursors Following Molecular and Genetic Disruption of the Outer Limiting Membrane (2008) (1)
Mirtron gene therapy for the treatment of rhodopsin-related dominant retinitis pigmentosa (2019) (1)
Smart Specs: Electronic vision enhancement in real-life scenarios (2016) (1)
A mobile image enhancement system for sight impaired individuals (2016) (1)
Is subretinal AAV gene replacement still the only viable treatment option for choroideremia? (2021) (1)
Outer retinal and choriocapillaris modifications in choroideremia: three differentially impaired retinal regions and the potential diagnostic role of the external limiting membrane (2022) (1)
Binocular Visual Function in a Pre-Presbyopic Patient with Uniocular Cataract Undergoing Cataract Surgery with a Multifocal Intraocular Lens (2020) (1)
First-in-human study of the safety and viability of intraocular robotic surgery (2018) (1)
Retinal Gene Therapy for Choroideremia: In Vitro Testing for Gene Augmentation Using an Adeno-Associated Viral (AAV) Vector. (2018) (1)
Development of a Murine Model of AMD by Overexpression of Complement Component 3 in the RPE of MCP-1-/- and Wild-Type Mice (2008) (0)
Vector shedding and immunology results from a gene therapy clinical trial for choroideremia (2018) (0)
A fragmented AAV dual vector strategy for delivery of over-sized genes leads to expression of hybrid transcripts (2016) (0)
Reply to: Comment on Cross-over to Photodynamic Therapy or Micropulse Laser After Failure of Primary Treatment of Chronic Central Serous Chorioretinopathy. (2020) (0)
Identification And Functional Assessment Of Residual Cones Present In Eyes With End Stage Retinal Dystrophy (2012) (0)
Retina High Symmetry of Visual Acuity and Visual Fields in RPGR-Linked Retinitis Pigmentosa (2017) (0)
Investigating cell fusion between the donor and host retina after photoreceptor precursor transplantation (2016) (0)
Digital Technology in Somatic and Gene Therapy Trials of Pediatric Patients With Ocular Diseases: Protocol for a Scoping Review (2019) (0)
Vector shedding and immunology measures in a choroideremia gene therapy trial (2019) (0)
Non–Integrating Lentiviral Vectors for Ocular Gene Transfer (2006) (0)
Spontaneous expulsive hemorrhage and oral anticoagulant therapy (1998) (0)
Long Term Functional and Structural Outcomes of Macular Translocation and Autologous Rpe Choroid Patch Graft for Treatment of Exudative Age-Related Macular Degeneration (2008) (0)
Development Of A Simulated Model For Battlefield Retinal Laser Injury (2012) (0)
Assessment of endogenous silencing of a cone-specific gene (Cnga3) delivered to rods using an AAV2/5 vector with CBA promoter. (2014) (0)
Restoration Of Cone Function By rAAV2/5.CNGA3 Gene Therapy In A Mouse Model Of Achromatopsia Developed To Assess Visual Behaviour (2011) (0)
A dual variable Markov model to assess the potential benefits of choroideremia gene therapy on quality adjusted life years (QALYs) (2018) (0)
PM Reliability of Quick Contrast Sensitivity Function Testing in Adults without Ocular Disease and Patients with Retinitis Pigmentosa (2016) (0)
Harnessing the potential of practice‐based clinical optometry research in the United Kingdom (2022) (0)
Beneficial effects on vision in patients undergoing retinal gene therapy for choroideremia (2018) (0)
Variations in Ocular Biometry and Refraction in Pakistani Adults – Results of the Pakistan National Blindness and Visual Impairment Survey (2006) (0)
British Congress of Optometry and Vision Science (COVS) Abstracts 2020 (2021) (0)
An optimized AAV vector for rod-specific gene expression (2018) (0)
Envisioning the development of a CRISPR-Cas mediated base editing strategy for a patient with a novel pathogenic CRB1 single nucleotide variant (2022) (0)
RPE Patch Graft Auto–Transplantation in Macular Degeneration: A Prospective Cohort Study (2006) (0)
Changes on multimodal imaging after treatment with photodynamic therapy or high-density subthreshold micropulse laser in chronic central serous chorioretinopathy (2019) (0)
Choroideremia and Other Hereditary Conditions Manifesting with Choroidal Atrophy (2021) (0)
Analysis of REP1 protein expression in blood leukocytes in typical choroideremia patients without an identifiable REP1 gene mutation (2014) (0)
Cone opsins and Crx are gene therapy candidates for the revival of cone photoreceptors in an RP mouse model (2017) (0)
In vivo Phenotyping Reveals That the Age-Related Retinal Degeneration in Ccl2/Cx3cr1 Double Knockout Mice Is Focal and Closely Associated With Inner Retinal Autofluorescent Lesions (2010) (0)
In vivo Phenotyping Reveals That the Age-Related Retinal Degeneration in Ccl2/Cx3cr1 Double Knockout Mice Is Focal and Closely Associated With Inner Retinal Autofluorescent Lesions (2010) (0)
Evaluation of the efficiency and specificity of short variants of the human PDE6b promoter in photoreceptor-like cells in vitro and ex vivo. (2017) (0)
Non-identical monozygotic twins with RPGR-associated Retinitis Pigmentosa (2019) (0)
INVESTIGATION OF THE RELATIONSHIP BETWEEN LEVELS OF CHM GENE EXPRESSION AND RATE OF DISEASE PROGRESSION IN CHOROIDEREMIA (2017) (0)
Retina A Novel Achromatopsia Mouse Model Resulting From a Naturally Occurring Missense Change in Cngb 3 (2018) (0)
A Novel Achromatopsia Mouse Model Resulting From a Naturally Occurring Missense Change in Cngb3. (2018) (0)
Enhancement of AAV Transduction Using Anti-Malarial Drugs, Hydroxychloroquine and Chloroquine (2018) (0)
Cost-effectiveness of Choroideremia Gene Therapy (2019) (0)
The accurate quantification of AAV genomic titre depends on the conformation of the plasmid reference (2018) (0)
Gene therapy for choroideremia: Early functional and anatomical recovery after subfoveal vector injection (2014) (0)
Correlation with Accumulation of A2E, Retinal Function and Histology - Supplementary figures and tables - (2017) (0)
AAV2-mediated gene therapy for choroideremia: 5-year results and alternate anti-sense oligonucleotide therapy. (2022) (0)
Assessment of adjunctive gene therapy to dormant cones in end-stage retinitis pigmentosa (2018) (0)
Reply - Re: van Dijk et al.: Half-dose photodynamic therapy versus high-density subthreshold micropulse laser treatment in patients with chronic central serous chorioretinopathy: the PLACE trial (Ophthalmology. 2018;125:1547-1555) (2019) (0)
Investigating treatment options for battlefield retinal laser injury (2013) (0)
A Novel Achromatopsia Mouse Model Resulting From a Naturally Occurring Missense Change in Cngb3. (2018) (0)
Sub-retinal implantation of the Retinal Implant Alpha AMS chip using integrated intra-operative optical coherence tomography (2017) (0)
Intracellular localisation of human bestrophin in neuronal cells after transduction with an AAV2.CBA.hBEST1.WPRE vector (2014) (0)
Generation Of Photoreceptor Phenotypes From Induced Nrl-gfp Mouse Hair Follicle-derived Epithelial Stem Cells (2011) (0)
Fundus Autofluorescence in the Abca4-/- Mouse, an Animal model for Stargardt disease - Correlation with Retinal Function, Histology and Accumulation of A2E (2012) (0)
AAV-mediated delivery of ABCA4 to the photoreceptors of Abca4-/- mice using an overlapping dual vector strategy (2017) (0)
Prenylation of Rab6a as a Potency Assay for Choroideremia Gene Therapy (2017) (0)
Future Perspectives of Prime Editing for the Treatment of Inherited Retinal Diseases (2023) (0)
Functional expression of Rab escort protein 1 following AAV2-mediated gene delivery in the retina of choroideremia mice and human cells ex vivo (2013) (0)
AAV-Mediated Expression of Secreted Human Ciliary Neurotropic Factor (hCNTF) Leads to Long-Term Preservation of Cone Photoreceptors in an Autosomal Recessive Model of Retinitis Pigmentosa (2013) (0)
Sunday 29 October (2017) (0)
Visual outcome in patients with idiopathic multifocal choroiditis (2004) (0)
Preliminary results in 18 patients undergoing retinal gene therapy for X-linked retinitis pigmentosa with codon-optimized AAV8-RPGR (2019) (0)
Structural and functional recovery following iatrogenic macular detachment for retinal gene therapy (2016) (0)
New CRISPR Tools to Correct Pathogenic Mutations in Usher Syndrome (2022) (0)
Optical coherence tomography in patients with Alpha IMS subretinal implant (2017) (0)
Photoreceptor Transplantation Can Restore Vision To The Totally Degenerate Retina (2011) (0)
A Review of CRISPR Tools for Treating Usher Syndrome: Applicability, Safety, Efficiency, and In Vivo Delivery (2023) (0)
RNA gene editing in the eye and beyond: The neglected tool of the gene editing armatorium? (2022) (0)
Edinburgh Research Explorer Novel gene function revealed by mouse mutagenesis screens for models of age-related disease (2016) (0)
CNTF Sustains Cone Photoreceptors in a Novel In Vitro Model of Retinitis Pigmentosa (2011) (0)
In vitro expression model for AAV2.VMD2.BEST1 gene therapy vectors (2019) (0)
Print Preview : Abstract Submission : Entry # 12 (2015) (0)
Assessment of Scotopic Function in Rod–Cone Inherited Retinal Degeneration With the Scotopic Macular Integrity Assessment (2023) (0)
Neuroprotection gene therapy in retinal degeneration (2013) (0)
Olfactory dysfunction in patients with CNGB1-related retinitis pigmentosa (2018) (0)
Assessment of 180° rotation of the choroid as a novel surgical treatment for age-related macular degeneration. (2012) (0)
Fluorescein angiography in altitude retinopathy (2000) (0)
High symmetry of visual field loss in X-linked retinitis pigmentosa (2016) (0)
An unusual presentation of choroideremia with macular dystrophy associated with early visual acuity loss (2018) (0)
Mobility performance in low vision: Capturing the dynamics of target finding and obstacle avoidance across different tasks (2014) (0)
Intraretinal Regeneration of Axotomised Retinal Ganglion Cells After AAV Mediated CNTF Delivery (2005) (0)
Full Thickness Macular Hole In Choroideremia Patients: Surgical Management And Outcome (2012) (0)
Retention of cone function in a murine rhodopsin knock-out model of retinitis pigmentosa by rhodopsin gene delivery (2015) (0)
Preclinical development of AAV-NPY gene therapy for epilepsy (2016) (0)
Re: van Dijk et al: Half-dose photodynamic therapy versus high-density subthreshold micropulse laser treatment in patients with chronic central serous chorioretinopathy: The PLACE trial Reply (2019) (0)
The new Retina Implant Alpha AMS: How does it work and what can blind patient see? (2017) (0)
Validation of Electronic Visual Acuity Measurement Against Standardised ETDRS Charts In Retinal Disease (2019) (0)
The central foveal thickness is similar to age-matched controls in early stage choroideremia. (2018) (0)
Similar Age-Related Loss of Photoreceptors in Wild-Type C 57 Bl / 6 and Ccl 2-Knockout Mice (2009) (0)
Relationship Between Microperimetry and Goldmann Visual Field Variability In Retinitis Pigmentosa (2014) (0)
Reply. (2019) (0)
Subretinal delivery of human melanopsin using capsid mutant AAV 2/8 Y733F results in sustained expression at one year with restoration of pupil responses in the rd1 mouse (2014) (0)
Choroidal Thickness in Choroideremia (2014) (0)
Is RPGR-related retinal dystrophy associated with systemic disease? A case series. (2023) (0)
Chapter 121 – Retinal Pigment Epithelium and Choroid Translocation in Patients with Age-Related Macular Degeneration (2013) (0)
Effect of single guide nucleotide mismatch in CRISPR/Cas9-mediated disruption of the human rhodopsin gene in vitro. (2019) (0)
Immature neural retinal cells integrate and differentiate into photoreceptors when transplanted into the mouse subreitnal space at post-natal day 1 (2005) (0)
Learning And Teaching In Human Anatomy (2009) (0)
Reply. (2019) (0)
Retinal cell replacement (2013) (0)
Successful Photoreceptor Transplantation Into the Aged Ccl2/Mcp-1 Mouse Model of Age-Related Macular Degeneration (2008) (0)
A detailed in vivo analysis of the retinal nerve fibre layer (RNFL) in choroideremia (2018) (0)
391. Effective Gene Therapy with Non-Integrating Lentivirus Vectors (2005) (0)
Assessment of Visual Function by Electroretinography following rAAV2-CHM/REP1 Gene Therapy in a Mouse Model of Choroideremia (2012) (0)
SLOWLY PROGRESSIVE RETINITIS PIGMENTOSA CAUSED BY A NOVEL COMPOUND HETEROZYGOUS MUTATION IN THE MAK GENE (2017) (0)
Overexpression of developmentally regulated neurotrophins in the adult mouse retina to facilitate integration of transplanted photoreceptor precursor cells (2008) (0)
AN IMPROVED MODEL OF ACHROMATOPSIA FOR PRE-CLINICAL DEVELOPMENT OF GENE AND CELL THERAPIES (2017) (0)
Enhancement of Adeno-Associated Virus-Mediated Gene Therapy Using Hydroxychloroquine in Murine and Human Tissues (2023) (0)
Retinitis pigmentosa caused by variants in SNRNP200 (2019) (0)
A naturally occurring mouse model of achromatopsia caused by a novel missense change in Cngb3. (2017) (0)
Human opsin-G-protein fusion proteins as potential light sensitizers (2014) (0)
Chapter 11 – Gene Therapy for Retinal Disease (2015) (0)
AAV vectors for use in gene therapy choroideremia (2012) (0)
Regeneration of the retina by stem cell transplantation therapy (2013) (0)
Autologous Bruch’s Membrane Rotation As A Potential Adjunct To Retinal Pigment Epithelium Cell Replacement Therapy For Age Related Macular Degeneration (2012) (0)
Functional expression of Bestrophin-1 in vitro following transduction with AAV-BEST1 vectors (2016) (0)
Assessment Of Adeno-associated Virus Serotypes In Transducing Human Retina Using An Ex-vivo Tissue Culture System (2012) (0)
Autologous Bruch’s Membrane Rotation As A Potential Adjunct To Retinal Pigment Epithelium Cell Replacement Therapy For Age Related Macular Degeneration (2012) (0)
Potential CRISPR Base Editing Therapeutic Options in a Sorsby Fundus Dystrophy Patient (2022) (0)
The Outer Limiting Membrane as a Barrier to Photoreceptor Integration, After Transplantation to the Subretinal Space of the Adult Mouse (2007) (0)
Developing new treatments for inherited retinal degenerations (2016) (0)
Benign idiopathic haemorrhagic retinopathy. (2002) (0)
Gene Transfer Into Corneal, Trabecular Meshwork And Retinal Cells Using Pseudotyped Lentiviral Vectors (2012) (0)
Using Rho Kinase Inhibitors for Retinal Detachment-Reply. (2017) (0)
Non-syndromic inherited retinal disease: choroideremia (2019) (0)
Rapid Quantification of the Binocular Visual Field for Clinical Trials: Performance of a Modified Esterman Supra-Threshold Test Implemented with the Open Perimetry Interface (2022) (0)
Identification of a potential new mouse model of chromatopsia through spontaneous occurrence of cone pathway function loss (2016) (0)
Retina Monoallelic ABCA 4 Mutations Appear Insufficient to Cause Retinopathy : A Quantitative Autofluorescence Study (2015) (0)
Assessment of low luminance visual acuity as a functional measurement in two distinct types of inherited retinal degeneration. (2019) (0)
Assessing Transduction Of The Degenerate Retina With AAV2/5 Using In Vivo Imaging And Immunocytochemistry (2011) (0)
A 2020 vision of ocular gene therapy (2020) (0)
Endpoints for Measuring Efficacy in Clinical Trials for Inherited Retinal Disease (2021) (0)
Codon optimized RPGR leads to improved stability and rescue with AAV8 gene therapy in X-linked retinitis pigmentosa (2017) (0)
RNA Editing for Usher Syndrome Using CRISPR-Cas13 (2020) (0)
SUBRETINAL GENE THERAPY WITH INTRAOPERATIVE OPTICAL COHERENCE TOMOGRAPHY GUIDANCE (2017) (0)
Impact of vital dyes on transduction efficiency of AAV vectors used in retinal gene therapy (2016) (0)
Assessment of AAV dual vector safety in the Abca4 KO mouse model (2019) (0)
Application Of RNAi To Unravel The Melanopsin Phototransduction Pathway (2011) (0)
Quantitative assessment of photoreceptor degeneration by confocal scanning laser ophthalmoscopy in two mouse models of retinitis pigmentosa (2017) (0)
Risks should be weighed against alternative therapies (2017) (0)
Results from a Multicenter Trial with the New Electronic Subretinal Implant Alpha AMS in 15 Patients Blind from Inherired Retinal Dystrophies (RD) (2017) (0)
The Effect of Ciliary Neurotrophic Factor Gene Therapy on Retinal Ganglion Cell Axon Survival in a Rat Model of Experimental Glaucoma (2008) (0)
Cell-Mediated Inflammatory Response to AAV Gene Therapy in the Retina (2020) (0)
EX VIVO AAV-MEDIATED GENE EXPRESSION IN THE HUMAN RETINA (2017) (0)
Barriers to Integration of Transplanted Photoreceptor Precursors: Gliosis in Crb1rd8/rd8 and Rho-/- Mouse Models of Retinal Degeneration (2009) (0)
Phenotypic and Genetic Characteristics in a Cohort of Patients with Usher Genes (2022) (0)
Hydroxychloroquine enhances the efficacy of retinal gene therapy (2018) (0)
British Society for Gene and Cell Therapy Annual Conference University College London Institute of Child Health Friday 15(th) April 2016 Conference Abstracts. (2016) (0)
The Ambulatory Care Clinical Skills Program: Type 2 Diabetes Mellitus Management Module (2001) (0)
Functional expression of Bestrophin-1 in vitro following transduction with viral vectors. (2016) (0)
Response: ‘letter to the editor: emerging gene therapy products for RPGR-associated X-linked retinitis pigmentosa’ (2022) (0)
Gene Therapy For Choroideremia - Initial Report On A New Clinical Trial (2012) (0)
Light-driven Circadian Behaviours Are Preserved In Visually Impaired Opa1 Mutant Mice (2012) (0)
Transplantation of Ex-Vivo Genetically Modified Photoreceptor Precursors (2014) (0)
Transgene expression in the retina following AAV transduction: the WPRE effect (2016) (0)
The senescence marker P16(ink4a) is expressed in ocular astrocytes (2018) (0)
Genetic findings in over 600 individuals with inherited retinal disorders in Finland (2022) (0)
Assessment of Longterm Neuroprotection by CNTF Gene Transfer in a Mouse Inherited Retinal Degeneration (2007) (0)
Compound dominant-null heterozygosity in a family with RP1-related retinal dystrophy (2022) (0)
Kinetics of Rod Photoreceptor Precursor Integration Following Transplantation in the Adult Mouse Retina (2007) (0)
A 2020 vision of ocular gene therapy (2020) (0)
Characterizing Visual Fields in RPGR Related Retinitis Pigmentosa Using Octopus Static-Automated Perimetry (2022) (0)
Neuroprotection of cone photoreceptors in retinitis pigmentosa (2013) (0)
AAV2/2-CBA-REP1 Vector with WPRE Provides Functional Expression of the Transgene in Choroideremia Mouse Knock-Out and Patient Cells (2012) (0)
Activation of nuclear and cytosolic innate immunity by AAV gene therapy in the retina (2016) (0)
Immunological testing in choroideremia patients undergoing gene therapy (2014) (0)
Fundus Fluorescence Imaging in Mice Using a Scanning Laser Ophthalmoscope (2011) (0)
Evaluation of an optimised injection system for retinal gene therapy (2014) (0)
Cone Photoreceptor Death Occurring Secondary To Retinal Pigment Epithelium Loss Assessed In Vivo In Transgenic Fluorescent Reporter Mice (2012) (0)
A critical period for regeneration in the marsupial (1998) (0)
Optimising Testing Strategies When Conducting MAIA Microperimetry: MAIA Optimisation and Evolution (2018) (0)
Neurodegeneration in the brain – before or after the retina? (2018) (0)
Usher genes; from a clinical and genetic perspective (2018) (0)
Genotype-Phenotype Analysis of Three Novel NR2E3 Mutations (2019) (0)
Comparative Analysis of Neural Stem Cells Isolated From the Iris, Pars Plana and Ciliary Body of the Porcine Eye (2007) (0)
Assessment of the relationship between CHM gene expression and rate of disease progression in choroideremia (2017) (0)
The human retinoblastoma WERI-Rb1 cell line as an in vitro model for photoreceptor-specific AAV transgene expression (2017) (0)
Re: Song et al., Toxicology and Pharmacology of an AAV Vector Expressing Codon-Optimized RPGR in RPGR-Deficient Rd9 Mice. Hum Gene Ther Clin Dev 2018; 29(4):188-197. (2019) (0)
Characterization Of A Novel Gene Therapy Reporter Vector (rAAV2/5-CBA-CNGA3-IRES-GFP) In A Mouse Model Of Achromatopsia (2012) (0)
Assessing Residual Photoreceptor Morphology in Choroideremia (2020) (0)
Pre-clinical Gene Therapy Studies In Choroideremia Mouse Models Using AAV Vectors (2012) (0)
Investigation of intracellular innate immune responses to AAV gene therapy in the retina. (2017) (0)
Quantitative in vivo Analysis of Cone Degeneration Secondary to a Rhodopsin Mutation (2010) (0)
Quality of Life Measures in Patients with Retinal Degeneration (2017) (0)
Preliminary Findings from the Oxford Retinal Implant Alpha AMS Trial (2016) (0)
Validation of Staphylococcus aureus Cas9 gRNAs targeting EGFP present in the rod cells of the Nrl-EGFP mouse line. (2018) (0)
Photoreceptor-specific AAV gene replacement enhanced by the adjunctive use of hydroxychloroquine in vivo (2019) (0)
A semi-automated phenotypic RPE in vitro scratch assay for screening of small molecule compounds able to influence RPE wound healing (2019) (0)
Gene therapy and treatment trials (2022) (0)
Biocompatibility and stability of an AAV vector for choroideremia gene therapy following passage through its surgical device (2018) (0)
Optimization of an in vitro model for assessing the survival of post-mitotic photoreceptors and Muller glial cells (2018) (0)

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