Robert Shapiro
American chemist
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Chemistry
Robert Shapiro 's Degrees
- PhD Chemistry University of California, Berkeley
- Bachelors Chemistry City College of New York
Why Is Robert Shapiro Influential?
(Suggest an Edit or Addition)According to Wikipedia, Robert Shapiro was professor emeritus of chemistry at New York University. He is best known for his work on the origin of life, having written two books on the topic: Origins, a Skeptic’s Guide to the Creation of Life on Earth and Planetary Dreams . He opposed the RNA world hypothesis, and held that the spontaneous emergence of a molecule as complicated as RNA is highly unlikely. Instead, he proposed that life arose from some self-sustaining and compartmentalized reaction of simple molecules: "metabolism first" instead of "RNA first". This reaction would have to be able to reproduce and evolve, eventually leading to RNA. He claimed that in this view life is a normal consequence of the laws of nature and potentially quite common in the universe.
Robert Shapiro 's Published Works
Published Works
- Molecular recognition of human angiogenin by placental ribonuclease inhibitor—an X‐ray crystallographic study at 2.0 Å resolution (1997) (191)
- Origins: A Skeptic's Guide to the Creation of Life on Earth (1986) (175)
- Small Molecule Interactions were Central to the Origin of Life (2006) (170)
- Prebiotic ribose synthesis: A critical analysis (1986) (164)
- Prebiotic cytosine synthesis: a critical analysis and implications for the origin of life. (1999) (156)
- Nucleic acid reactivity and conformation. II. Reaction of cytosine and uracil with sodium bisulfite. (1973) (131)
- A Replicator Was Not Involved in the Origin of Life (2000) (122)
- A simpler origin for life. (2007) (119)
- The prebiotic role of adenine: A critical analysis (1995) (106)
- Damage to DNA Caused by Hydrolysis (1981) (96)
- The search for alien life in our solar system: strategies and priorities. (2009) (90)
- Heterogeneous Photocatalytic Oxidation of Cyanide Ion in Aqueous Solutions at Ti 02 Powder (87)
- Chemistry of guanine and its biologically significant derivatives. (1968) (79)
- The improbability of prebiotic nucleic acid synthesis (2004) (59)
- Are Src family kinases involved in cell cycle resumption in rat eggs? (2004) (57)
- Metalloenzymes in DNA repair. Escherichia coli endonuclease IV and Saccharomyces cerevisiae Apn1. (1991) (54)
- Specific Deamination of RNA by Sodium Bisulphite (1970) (45)
- Stereochemical, structural, and thermodynamic origins of stability differences between stereoisomeric benzo[a]pyrene diol epoxide deoxyadenosine adducts in a DNA mutational hot spot sequence. (2001) (43)
- Potent Inhibition of Mammalian Ribonucleases by 3′,5′-Pyrophosphate-linked Nucleotides* (1999) (43)
- MR imaging in adults with Gaucher disease type I: evaluation of marrow involvement and disease activity (2004) (42)
- Structural and thermodynamic features of spiroiminodihydantoin damaged DNA duplexes. (2005) (41)
- Reaction of acrolein with cytosine and adenine derivatives (1988) (36)
- Effect of ring size on conformations of aromatic amine-DNA adducts: the aniline-C8 guanine adduct resides in the B-DNA major groove. (1998) (33)
- Minor-groove binding models for acetylaminofluorene modified DNA. (1989) (31)
- Modification of polyuridylic acid by bisulfite: effect on double helix formation and coding properties. (1972) (30)
- Spiroiminodihydantoin lesions derived from guanine oxidation: structures, energetics, and functional implications. (2005) (27)
- Conformation of d(CpG) modified by the carcinogen 4-aminobiphenyl: a combined experimental and theoretical analysis. (1986) (25)
- REACTIONS WITH PURINES AND PYRIMIDINES * (1969) (24)
- Synthesis and conformation of a dinucleoside monophosphate modified by aniline. (1988) (20)
- Binding of Phosphate and pyrophosphate ions at the active site of human angiogenin as revealed by X‐ray crystallography (2001) (20)
- A new rationale for returning to the Moon? Protecting civilization with a sanctuary (2009) (20)
- Conformational analysis of the major DNA adduct derived from the food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline. (1999) (20)
- Mutagenic nucleotide incorporation and hindered translocation by a food carcinogen C8-dG adduct in Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4): modeling and dynamics studies (2006) (19)
- Comments on `Concentration by Evaporation and the Prebiotic Synthesis of Cytosine' (2002) (19)
- Accommodation of an N-(deoxyguanosin-8-yl)-2-acetylaminofluorene adduct in the active site of human DNA polymerase iota: Hoogsteen or Watson-Crick base pairing? (2009) (19)
- A slipped replication intermediate model is stabilized by the syn orientation of N-2-aminofluorene- and N-2-(acetyl)aminofluorene-modified guanine at a mutational hotspot. (1998) (18)
- Conformations of stereoisomeric base adducts to 4-hydroxyequilenin. (2003) (18)
- Equilenin-derived DNA adducts to cytosine in DNA duplexes: structures and thermodynamics. (2005) (17)
- Solution properties and computational analysis of an oligodeoxynucleotide containing N-(deoxyguanosin-8-yl)-1-aminopyrene. (1996) (16)
- 4-hydroxyequilenin-adenine lesions in DNA duplexes: stereochemistry, damage site, and structure. (2007) (16)
- Crosslinking of nucleic acids and proteins by bisulfite. (1977) (14)
- A comparison of the predicted and X-ray structures of angiogenin. Implications for further studies of model building of homologous proteins (1994) (14)
- Conformation of amine-modified DNA: 2-aminofluorene- and 2-(acetylamino)fluorene-modified deoxydinucleoside monophosphates with all possible nearest neighbors. A comparison of search and optimization methods. (1994) (14)
- Conformational properties of equilenin-DNA adducts: stereoisomer and base effects. (2008) (13)
- Extraosseous extension of Gaucher cell deposits mimicking malignancy (1994) (13)
- A molecular mechanics and dynamics study of the minor adduct between DNA and the carcinogen 2-(acetylamino)fluorene (dG-N2-AAF). (1997) (13)
- A new synthetic route to nucleotide adducts derived from N-acetylated and unacetylated 4-aminobiphenyl. (1988) (12)
- Molecular dynamics of a food carcinogen-DNA adduct in a replicative DNA polymerase suggest hindered nucleotide incorporation and extension. (2005) (12)
- On the structure of neoguanosine (1964) (11)
- Flexible 5-guanidino-4-nitroimidazole DNA lesions: structures and thermodynamics. (2006) (11)
- A simplified method for study of RNA conformation--reaction of formylmethionine transfer RNA with [14C]methylamine-bisulfite. (1974) (11)
- Major and minor groove conformations of DNA trimers modified on guanine or adenine by 4-aminobiphenyl: adenine adducts favor the minor groove. (1995) (9)
- A new chemical probe for single-stranded RNA. (1972) (9)
- The food mutagen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline: a conformational analysis of its major DNA adduct and comparison with the 2-amino-3-methylimidazo[4,5-f]quinoline adduct. (2001) (7)
- Detection of sulfur in fixed and embedded rat peritoneal mast cell granules by X‐ray energy dispersive spectroscopy (1986) (7)
- Structural and Stereoisomer Effects of Model Estrogen Quinone-Derived DNA Adducts: N6-(2-Hydroxyestron-6(α,β)-yl)-2′ -deoxyadenosine and N2-(2-Hydroxyestron-6(α,β )-yl)-2′-deoxyguanosine (2004) (6)
- Modification of E. coli ribosomes and coliphage MS2 RNA by bisulfite: effects on ribosomal binding and protein synthesis. (1975) (6)
- The effects of bisulfite on growth and macromolecular synthesis in Escherichia coli. (1983) (6)
- Site-directed mutagenesis of mammalian alcohol and sorbitol dehydrogenases map functional differences within the enzyme family. (1993) (6)
- Structural and stereoisomer effects of model estrogen quinone-derived DNA adducts: N6-(2-hydroxyestron-6(alpha,beta)-yl)-2'-deoxyadenosine and N2-(2-hydroxyestron-6(alpha,beta)-yl)-2'-deoxyguanosine. (2004) (5)
- Molecular Dynamics Simulation of a Tumorigenic Benzo[a]pyrene Metabolite Bound to DNA at a Single Strand‐Double Strand Junction a (1994) (5)
- Addition of Amino Acids and Related Substances to Nucleic Acids by Nucleophilic Catalysis (1976) (4)
- A Sceptic’S View (1988) (4)
- Mass sectrometric study of methylene cross‐linked derivatives of adenine and adenosine (1983) (4)
- Covalent Polycyclic Aromatic Hydrocarbon–DNA Adducts: Carcinogenicity, Structure, and Function (2011) (4)
- Prebiotic syntheses of the RNA bases: A critical analysis (1996) (2)
- FINANCIAL INTERMEDIARIES, CREDIT AVAILABILITY, AND AGGREGATE DEMAND (1966) (2)
- Astrobiology: Life's beginnings (2011) (2)
- Life, the Universe and anything goes (1993) (1)
- Environmental Evolution: Effects of the Origin and Evolution of Life on Planet Earth. Lynn Margulis , Clifford Matthews , Aaron Haselton (2001) (1)
- Reversal of growth inhibition in Escherichia coli by bisulfite. (1983) (1)
- Unusual Hydrogen Bonding Patterns in 2-Aminofluorene (AF) and 2-Acetylaminofluorene (AAF) Modified DNA (1990) (1)
- 17th Annual Conference on Mass Spectrometry and Allied Topics (ASTM Committee E-14 on Mass Spectrometry) Dallas, Texas 18th to 23rd May, 1969 (1969) (1)
- Modification of polyuridylic acid by bisulfite. II: Studies on ribosomal binding and enzymatic hydrolysis (1973) (1)
- La danse hip-hop. Apprentissage, transmission, socialisation (2002) (1)
- Interactions of carcinogens with DNA (deoxyribonucleic acid) (1989) (0)
- Molecular understanding of mutagenicity using potential energy methods. Progress report, July 1, 1992--September 30, 1993 (1993) (0)
- The Nature of Life: Classical and Contemporary Perspectives from Philosophy and Science: Small molecule interactions were central to the origin of life (2010) (0)
- Action of Environmental Agents on Nucleic Acids and Their Metabolism (2011) (0)
- Origins of Life.Freeman Dyson (1987) (0)
- Life's Origin as a Detective as a Detective Story (1986) (0)
- Origins of Life. Freeman DysonOrigins of Life on the Earth and in the Cosmos. Geoffrey Zubay (2001) (0)
- Book Review: Resignation in Protest, by Edward Weisband & Thomas M. Franck (1976) (0)
- 794 VARICELLA-ZOSTER INFECTIONS IN PEDIATRIC RESIDENTS: A GROWING CONCERN (1985) (0)
- [Book Review: Life's Origin: The Beginnings of Biological Evolution] (2003) (0)
- Unusual hydrogen bonding patterns in AF (aminofluorene) and AAF (acetylaminofluorene) modified DNA (1989) (0)
- Modeling DNA Replication Intermediates (1997) (0)
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