Robert Tjian
#3,998
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American biochemist
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Robert Tjianbiology Degrees
Biology
#114
World Rank
#205
Historical Rank
#66
USA Rank
Biochemistry
#31
World Rank
#41
Historical Rank
#20
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Biology
Robert Tjian's Degrees
- Bachelors Biochemistry University of California, Berkeley
Why Is Robert Tjian Influential?
(Suggest an Edit or Addition)According to Wikipedia, Robert Tjian is a Hong Kong-born American biochemist best known for his work on eukaryotic transcription. He is currently professor of biochemistry and molecular biology at the University of California, Berkeley and an Investigator of the Howard Hughes Medical Institute . On April 1, 2009, Tjian became the President of HHMI. On August 4, 2015, he announced that he would step down as President at the end of 2016.
Robert Tjian's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins. (1989) (2706)
- Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements (1987) (1736)
- Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain (1987) (1330)
- Transcription regulation and animal diversity (2003) (1301)
- Analysis of Sp1 in vivo reveals mutiple transcriptional domains, including a novel glutamine-rich activation motif (1988) (1260)
- The promoter-specific transcription factor Sp1 binds to upstream sequences in the SV40 early promoter (1983) (1203)
- Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1. (1987) (1145)
- Transcriptional activation: A complex puzzle with few easy pieces (1994) (1088)
- The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans (2008) (1032)
- Purification and biochemical characterization of the promoter-specific transcription factor, Sp1. (1986) (1027)
- Affinity purification of sequence-specific DNA binding proteins. (1986) (896)
- Control of eukaryotic messenger RNA synthesis by sequence-specific DNA-binding proteins (1985) (870)
- Structure and function of a human TAFII250 double bromodomain module. (2000) (853)
- Mechanism of transcriptional activation by Sp1: Evidence for coactivators (1990) (847)
- Promoter-specific activation of RNA polymerase II transcription by Sp1 (1986) (836)
- Orchestrated response: a symphony of transcription factors for gene control. (2000) (811)
- O-glycosylation of eukaryotic transcription factors: Implications for mechanisms of transcriptional regulation (1988) (778)
- Positive and negative regulation of transcription in vitro: Enhancer-binding protein AP-2 is inhibited by SV40 T antigen (1987) (768)
- A cellular DNA-binding protein that activates eukaryotic transcription and DNA replication (1987) (734)
- The activities of two Ets-related transcription factors required for drosophila eye development are modulated by the Ras/MAPK pathway (1994) (706)
- Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection (2016) (674)
- The proline-rich transcriptional activator of CTF/NF-I is distinct from the replication and DNA binding domain (1989) (661)
- Activation of the AIDS retrovirus promoter by the cellular transcription factor, Sp1. (1986) (638)
- Isolation of coactivators associated with the TATA-binding protein that mediate transcriptional activation (1991) (634)
- GC box binding induces phosphorylation of Sp1 by a DNA-dependent protein kinase (1990) (611)
- Imaging dynamic and selective low-complexity domain interactions that control gene transcription (2018) (609)
- A family of human CCAAT-box-binding proteins active in transcription and DNA replication: cloning and expression of multiple cDNAs (1988) (607)
- Isolation of transcription factors that discriminate between different promoters recognized by RNA polymerase II (1983) (601)
- Transcriptional coactivator complexes. (2001) (597)
- Activation of transcription by two factors that bind promoter and enhancer sequences of the human metallothionein gene and SV40 (1987) (594)
- Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway. (2003) (584)
- Transcription factor AP-2 is expressed in neural crest cell lineages during mouse embryogenesis. (1991) (572)
- Leucine repeats and an adjacent DNA binding domain mediate the formation of functional cFos-cJun heterodimers. (1989) (569)
- Two distinct transcription factors bind to the HSV thymidine kinase promoter in vitro (1985) (568)
- Nucleolar transcription factor hUBF contains a DNA-binding motif with homology to HMG proteins (1990) (566)
- Transcriptional selectivity of viral genes in mammalian cells (1986) (556)
- Fos-associated protein p39 is the product of the jun proto-oncogene. (1988) (542)
- Transcription from a TATA-less promoter requires a multisubunit TFIID complex. (1991) (539)
- Molecular cloning and functional analysis of Drosophila TAF110 reveal properties expected of coactivators (1993) (534)
- Cloning and expression of AP-2, a cell-type-specific transcription factor that activates inducible enhancer elements. (1988) (530)
- A glutamine-rich hydrophobic patch in transcription factor Sp1 contacts the dTAFII110 component of the Drosophila TFIID complex and mediates transcriptional activation. (1994) (526)
- p53 transcriptional activation mediated by coactivators TAFII40 and TAFII60. (1995) (488)
- Synergistic activation by the glutamine-rich domains of human transcription factor Sp1 (1989) (487)
- Single-Molecule Dynamics of Enhanceosome Assembly in Embryonic Stem Cells (2014) (487)
- Analysis of the DNA-binding and activation properties of the human transcription factor AP-2. (1991) (469)
- The binding site on SV40 DNA for a T antigen-related protein (1978) (448)
- Composite co-activator ARC mediates chromatin-directed transcriptional activation (1999) (446)
- Looping Back to Leap Forward: Transcription Enters a New Era (2014) (435)
- Multiple specific contacts between a mammalian transcription factor and its cognate promoters (1984) (431)
- Different activation domains of Sp1 govern formation of multimers and mediate transcriptional synergism. (1991) (421)
- Drosophila TAFII40 interacts with both a VP16 activation domain and the basal transcription factor TFIIB (1993) (416)
- Transcription factors that activate the Ultrabithorax promoter in developmentally staged extracts (1988) (394)
- Assembly of recombinant TFIID reveals differential coactivator requirements for distinct transcriptional activators (1994) (380)
- An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis (2006) (378)
- CTCF and cohesin regulate chromatin loop stability with distinct dynamics (2016) (377)
- The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1 (1999) (369)
- Overcoming the bottleneck to widespread testing: a rapid review of nucleic acid testing approaches for COVID-19 detection (2020) (366)
- Functional domains and upstream activation properties of cloned human TATA binding protein. (1990) (364)
- Distinct regions of Sp1 modulate DNA binding and transcriptional activation. (1988) (363)
- Phosphorylation of the transcription factor PHO4 by a cyclin-CDK complex, PHO80-PHO85. (1994) (359)
- The TATA-binding protein and associated factors are integral components of the RNA polymerase I transcription factor, SL1 (1992) (358)
- TAFs revisited: more data reveal new twists and confirm old ideas. (2000) (353)
- Transcriptional feedback control of insulin receptor by dFOXO/FOXO1. (2005) (344)
- Transcription factors IIE and IIH and ATP hydrolysis direct promoter clearance by RNA polymerase II (1994) (342)
- TAFs mediate transcriptional activation and promoter selectivity. (1996) (340)
- Coactivators for a proline-rich activator purified from the multisubunit human TFIID complex. (1991) (318)
- ES cell pluripotency and germ-layer formation require the SWI/SNF chromatin remodeling component BAF250a (2008) (316)
- Evaluating phase separation in live cells: diagnosis, caveats, and functional consequences (2019) (316)
- DNA looping between sites for transcriptional activation: self-association of DNA-bound Sp1. (1991) (314)
- Nucleosomes impede Cas9 access to DNA in vivo and in vitro (2016) (310)
- Functional cooperativity between transcription factors UBF1 and SL1 mediates human ribosomal RNA synthesis. (1988) (308)
- Bidirectional SV40 transcription mediated by tandem Sp1 binding interactions. (1985) (303)
- Binding of TAFs to core elements directs promoter selectivity by RNA polymerase II (1995) (302)
- Repression of p53-mediated transcription by MDM2: a dual mechanism. (1997) (298)
- Dynamics of CRISPR-Cas9 genome interrogation in living cells (2015) (290)
- Transcription factor AP-4 contains multiple dimerization domains that regulate dimer specificity. (1990) (290)
- Direct interaction between Sp1 and the BPV enhancer E2 protein mediates synergistic activation of transcription (1991) (285)
- Regulating the Regulators Lysine Modifications Make Their Mark (2003) (277)
- Structure, Function, and Activator-Induced Conformations of the CRSP Coactivator (2002) (275)
- Enhancer binding factors AP-4 and AP-1 act in concert to activate SV40 late transcription in vitro (1988) (263)
- Resolving the 3D landscape of transcription-linked mammalian chromatin folding (2019) (262)
- Selectivity of chromatin-remodelling cofactors for ligand-activated transcription (2001) (255)
- Diversified transcription initiation complexes expand promoter selectivity and tissue-specific gene expression. (2003) (245)
- Bromodomains mediate an acetyl-histone encoded antisilencing function at heterochromatin boundaries. (2003) (244)
- Sp1 binds to promoter sequences and activates herpes simplex virus ‘immediate-early’ gene transcription in vitro (1985) (243)
- TBP-TAF complexes: selectivity factors for eukaryotic transcription. (1994) (240)
- Contacts in Context: Promoter Specificity and Macromolecular Interactions in Transcription (1996) (236)
- Regulation of transcription factor AP-2 by the morphogen retinoic acid and by second messengers. (1989) (233)
- Characterization of a dimerization motif in AP-2 and its function in heterologous DNA-binding proteins. (1991) (232)
- Near-atomic resolution visualization of human transcription promoter opening (2016) (228)
- Transcription factor Sp1 recognizes a DNA sequence in the mouse dihydrofolate reductase promoter (1986) (221)
- SV40 gene expression is modulated by the cooperative binding of T antigen to DNA (1981) (220)
- CASFISH: CRISPR/Cas9-mediated in situ labeling of genomic loci in fixed cells (2015) (215)
- TAFII250 Is a Bipartite Protein Kinase That Phosphorylates the Basal Transcription Factor RAP74 (1996) (214)
- Maintenance of spermatogenesis requires TAF4b, a gonad-specific subunit of TFIID. (2005) (213)
- Drosophila TAFII150: similarity to yeast gene TSM-1 and specific binding to core promoter DNA. (1994) (208)
- TRF2 associates with DREF and directs promoter-selective gene expression in Drosophila (2002) (207)
- Chromatin, TAFs, and a novel multiprotein coactivator are required for synergistic activation by Sp1 and SREBP-1a in vitro. (1998) (205)
- Unexpected roles for core promoter recognition factors in cell-type-specific transcription and gene regulation (2010) (205)
- Cloning and expression of human TAFII250: a TBP-associated factor implicated in cell-cycle regulation (1993) (204)
- Topography of simian virus 40 A protein-DNA complexes: arrangement of pentanucleotide interaction sites at the origin of replication (1983) (199)
- Multiple TAFIIs Directing Synergistic Activation of Transcription (1995) (198)
- A dynamic mode of mitotic bookmarking by transcription factors (2016) (198)
- Requirement of Tissue-Selective TBP-Associated Factor TAFII105 in Ovarian Development (2001) (195)
- Diverse transcriptional functions of the multisubunit eukaryotic TFIID complex. (1992) (194)
- Human DNA sequences homologous to a protein coding region conserved between homeotic genes of Drosophila (1984) (191)
- Human rRNA transcription is modulated by the coordinate binding of two factors to an upstream control element (1986) (189)
- TATA box-binding protein (TBP)-related factor 2 (TRF2), a third member of the TBP family. (1999) (187)
- Biochemical analysis of transcriptional activation by Jun: Differential activity of c- and v-Jun (1989) (186)
- Regulation of simian virus 40 early transcription in vitro by a purified tumor antigen. (1980) (186)
- Isolation and characterization of the Drosophila gene encoding the TATA box binding protein, TFIID (1990) (184)
- In Vitro Analysis of Huntingtin-Mediated Transcriptional Repression Reveals Multiple Transcription Factor Targets (2005) (182)
- Characterization of drosophila transcription factors that activate the tandem promoters of the alcohol dehydrogenase gene (1985) (181)
- T-antigen-DNA polymerase alpha complex implicated in simian virus 40 DNA replication (1986) (181)
- 3D imaging of Sox2 enhancer clusters in embryonic stem cells (2014) (177)
- Transcription Properties of a Cell Type–Specific TATA-Binding Protein, TRF (1997) (177)
- Transcription factor IIE binds preferentially to RNA polymerase IIa and recruits TFIIH: a model for promoter clearance. (1994) (176)
- Polybromo protein BAF180 functions in mammalian cardiac chamber maturation. (2004) (173)
- Promoter-selective transcriptional defect in cell cycle mutant ts13 rescued by hTAFII250. (1994) (171)
- Control of Embryonic Stem Cell Lineage Commitment by Core Promoter Factor, TAF3 (2011) (171)
- Human TAFII105 Is a Cell Type–Specific TFIID Subunit Related to hTAFII130 (1996) (169)
- Human CRSP interacts with RNA polymerase II CTD and adopts a specific CTD-bound conformation. (2002) (168)
- Control of c-Jun activity by interaction of a cell-specific inhibitor with regulatory domain δ: Differences between v- and c-Jun (1990) (168)
- Biological activity of purified simian virus 40 T antigen proteins. (1978) (165)
- A DNA Repair Complex Functions as an Oct4/Sox2 Coactivator in Embryonic Stem Cells (2011) (164)
- Switching of the core transcription machinery during myogenesis. (2007) (161)
- Evidence for DNA-mediated nuclear compartmentalization distinct from phase separation (2019) (160)
- TAF4 nucleates a core subcomplex of TFIID and mediates activated transcription from a TATA-less promoter (2006) (160)
- Purification and characterization of a transcription factor that confers promoter specificity to human RNA polymerase I (1985) (159)
- Regulatory diversity among metazoan co-activator complexes (2004) (157)
- Recent evidence that TADs and chromatin loops are dynamic structures (2017) (156)
- Largest subunit of Drosophila transcription factor IID directs assembly of a complex containing TBP and a coactivator (1993) (155)
- SREBP transcriptional activity is mediated through an interaction with the CREB-binding protein. (1996) (153)
- Two transcriptional activators, CCAAT-box-binding transcription factor and heat shock transcription factor, interact with a human hsp70 gene promoter (1987) (152)
- Construction and analysis of simian virus 40 origins defective in tumor antigen binding and DNA replication. (1980) (151)
- Structure and functional properties of human general transcription factor IIE (1991) (150)
- Multiple domains of the RNA polymerase I activator hUBF interact with the TATA-binding protein complex hSL1 to mediate transcription. (1992) (148)
- Purification and analysis of RNA polymerase II transcription factors by using wheat germ agglutinin affinity chromatography. (1989) (147)
- Biochemical activities of T-antigen proteins encoded by simian virus 40 A gene deletion mutants (1983) (141)
- Crystal structure of a lysozyme-tetrasaccharide lactone complex. (1974) (141)
- Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits. (1994) (140)
- MyoD targets TAF3/TRF3 to activate myogenin transcription. (2008) (140)
- Robust model-based analysis of single-particle tracking experiments with Spot-On (2018) (139)
- Three-dimensional structure of the human TFIID-IIA-IIB complex. (1999) (139)
- Distinct Classes of Chromatin Loops Revealed by Deletion of an RNA-Binding Region in CTCF. (2019) (138)
- Enzymatic activities associated with a purified simian virus 40 T antigen-related protein. (1979) (138)
- Codependent activators direct myoblast-specific MyoD transcription. (2008) (138)
- Climate change and the integrity of science. (2010) (137)
- Molecular cloning and expression of the 32-kDa subunit of human TFIID reveals interactions with VP16 and TFIIB that mediate transcriptional activation. (1995) (130)
- Functional analysis of NTF-1, a developmentally regulated Drosophila transcription factor that binds neuronal cis elements. (1989) (128)
- A new factor related to TATA-binding protein has highly restricted expression patterns in Drosophila (1993) (127)
- Transcription of herpes simplex virus tk sequences under the control of wild-type and mutant human RNA polymerase I promoters (1985) (125)
- Assembly of alternative multiprotein complexes directs rRNA promoter selectivity. (1990) (123)
- Assembly of transcriptionally active RNA polymerase I initiation factor SL1 from recombinant subunits. (1994) (120)
- Imaging transcription in living cells. (2009) (120)
- A novel strategy for constructing clustered point mutations. (1985) (118)
- Visualizing transcription factor dynamics in living cells (2018) (118)
- Use of monoclonal antibodies as probes of simian virus 40 T antigen ATPase activity. (1981) (117)
- Zeste encodes a sequence-specific transcription factor that activates the Ultrabithorax promoter in vitro (1988) (117)
- Two distinct promoter elements in the human rRNA gene identified by linker scanning mutagenesis (1986) (116)
- Binding of the Sp1 transcription factor by the human Harvey ras1 proto-oncogene promoter. (1986) (114)
- SV40 T antigen binding site mutations that affect autoregulation (1983) (114)
- The Drosophila Fos-related AP-1 protein is a developmentally regulated transcription factor. (1990) (113)
- TAFs and TFIIA mediate differential utilization of the tandem Adh promoters (1995) (112)
- Promoter-selective properties of the TBP-related factor TRF1. (2000) (109)
- Molecular mechanisms governing species-specific transcription of ribosomal RNA (1989) (108)
- Shifting players and paradigms in cell-specific transcription. (2009) (108)
- Expression of homologous homeo-box-containing genes in differentiated human teratocarcinoma cells and mouse embryos (1985) (108)
- Drosophila TFIIA-L is processed into two subunits that are associated with the TBP/TAF complex. (1993) (107)
- Transcription of histone gene cluster by differential core-promoter factors. (2007) (106)
- Drosophila TFIIA directs cooperative DNA binding with TBP and mediates transcriptional activation. (1994) (105)
- A purified Drosophila homeodomain protein represses transcription in vitro (1989) (105)
- Biology of simian virus 40 (SV40) transplantation antigen (TrAg). VI. Mechanism of induction of SV40 transplantation immunity in mice by purified SV40 T antigen (D2 protein). (1980) (105)
- Temporal pattern of alcohol dehydrogenase gene transcription reproduced by Drosophila stage-specific embryonic extracts (1988) (104)
- A TRF1:BRF Complex Directs Drosophila RNA Polymerase III Transcription (2000) (104)
- Drosophila tissue-specific transcription factor NTF-1 contains a novel isoleucine-rich activation motif. (1993) (101)
- Transcription factor MIZ-1 is regulated via microtubule association. (2001) (99)
- DNA Template and Activator-Coactivator Requirements for Transcriptional Synergism by Drosophila Bicoid (1995) (99)
- The intertwined roles of transcription and repair proteins. (2013) (99)
- Coactivator and Promoter-Selective Properties of RNA Polymerase I TAFs (1995) (98)
- Protein-DNA interactions at the origin of simian virus 40 DNA replication. (1979) (97)
- IRES-mediated functional coupling of transcription and translation amplifies insulin receptor feedback. (2007) (96)
- Essential contact residues within SV40 large T antigen binding sites I and II identified by alkylation-interference (1984) (95)
- TAFII250-dependent transcription of cyclin A is directed by ATF activator proteins. (1997) (93)
- Mechanisms of transcriptional activation: differences and similarities between yeast, Drosophila, and man. (1997) (92)
- SV40 T antigen binds specifically to a cellular 53 K protein in vitro (1981) (89)
- Novel Jun‐ and Fos‐related proteins in Drosophila are functionally homologous to enhancer factor AP‐1. (1988) (88)
- A Glutamine-Rich Trail Leads to Transcription Factors (2002) (88)
- T antigen binding and the control of SV40 gene expression (1981) (87)
- Subnuclear segregation of genes and core promoter factors in myogenesis. (2011) (85)
- The dTAFII80 subunit of Drosophila TFIID contains β-transducin repeats (1993) (84)
- Cloning of murine RNA polymerase I-specific TAF factors: conserved interactions between the subunits of the species-specific transcription initiation factor TIF-IB/SL1. (1997) (83)
- Comparative chromosome mapping of a conserved homoeo box region in mouse and human (1985) (81)
- Coactivator cross-talk specifies transcriptional output. (2006) (81)
- Transcription initiation by human RNA polymerase II visualized at single-molecule resolution. (2012) (80)
- Downstream sequences affect transcription initiation from the adenovirus major late promoter (1986) (80)
- Guided nuclear exploration increases CTCF target search efficiency (2018) (80)
- Distinct conformational states of nuclear receptor–bound CRSP–Med complexes (2004) (79)
- A highly conserved domain of TFIID displays species specificity in vivo (1991) (79)
- TBP, Mot1, and NC2 establish a regulatory circuit that controls DPE-dependent versus TATA-dependent transcription. (2008) (77)
- Nutrient Availability and Growth: Regulation of Insulin Signaling by dFOXO/FOXO1 (2006) (75)
- A stable mode of bookmarking by TBP recruits RNA polymerase II to mitotic chromosomes (2018) (74)
- Cloning and expression of Drosophila TAFII60 and human TAFII70 reveal conserved interactions with other subunits of TFIID. (1993) (74)
- Expression of SV40 T antigen under control of adenovirus promoters (1981) (74)
- A mammalian host-vector system that regulates expression and amplification of transfected genes by temperature induction. (1985) (73)
- Structure and function of CRSP/Med2; a promoter-selective transcriptional coactivator complex. (2004) (73)
- Cryo-electron microscopy studies of human TFIID: conformational breathing in the integration of gene regulatory cues. (2006) (73)
- In vitro analysis of the Antennapedia P2 promoter: identification of a new Drosophila transcription factor. (1988) (72)
- The nucleosome remodeling factor (NURF) regulates genes involved in Drosophila innate immunity. (2008) (71)
- Charting Brachyury-mediated developmental pathways during early mouse embryogenesis (2014) (70)
- TAFII mutations disrupt Dorsal activation in the Drosophila embryo. (1998) (70)
- Determining cellular CTCF and cohesin abundances to constrain 3D genome models (2018) (70)
- Human TAFII250 interacts with RAP74: implications for RNA polymerase II initiation. (1995) (69)
- Eukaryotic coactivators associated with the TATA box binding protein (1992) (69)
- Structures of three distinct activator-TFIID complexes. (2009) (69)
- Transcription factors and the control of Drosophila development. (1989) (69)
- Single-molecule tracking of the transcription cycle by sub-second RNA detection (2014) (68)
- Regulation of human ribosomal RNA transcription. (1983) (68)
- The biochemistry of transcription in eukaryotes: a paradigm for multisubunit regulatory complexes. (1996) (68)
- Real-time imaging of Huntingtin aggregates diverting target search and gene transcription (2016) (67)
- Simian virus 40 small-t protein is required for loss of actin cable networks in rat cells (1980) (67)
- Molecular machines that control genes. (1995) (66)
- Multiple regions of TBP participate in the response to transcriptional activators in vivo. (1994) (66)
- v-Src and EJ Ras alleviate repression of c-Jun by a cell-specific inhibitor (1991) (66)
- Structural changes in TAF4b-TFIID correlate with promoter selectivity. (2008) (66)
- Properties of the simian virus 40 (SV40) large T antigens encoded by SV40 mutants with deletions in gene A (1986) (65)
- A cis‐acting element and associated binding factor required for CNS expression of the Drosophila melanogaster dopa decarboxylase gene. (1988) (65)
- Different functional domains of TAFII250 modulate expression of distinct subsets of mammalian genes. (2000) (62)
- Eukaryotic coactivators associated with the TATA box-binding protein (1992) (62)
- Antibody directed against Bacillus subtilis rho factor purified by sodium dodecyl sulfate slab gel electrophoresis. Effect on transcription by RNA polymerase in crude extracts of vegetative and sporulating cells. (1975) (61)
- Synergistic activation of transcription by UNC‐86 and MEC‐3 in Caenorhabditis elegans embryo extracts. (1995) (60)
- Genomes in Focus: Development and Applications of CRISPR-Cas9 Imaging Technologies. (2018) (59)
- Impaired cell fate through gain-of-function mutations in a chromatin reader (2019) (58)
- Taf7l cooperates with Trf2 to regulate spermiogenesis (2013) (58)
- Structure of the human Mediator-bound transcription preinitiation complex (2021) (58)
- Functional analysis of the human TAFII250 N-terminal kinase domain. (1998) (57)
- Purified Drosophila transcription factor, Adh distal factor-1 (Adf-1), binds to sites in several Drosophila promoters and activates transcription. (1990) (57)
- ecDNA hubs drive cooperative intermolecular oncogene expression (2020) (57)
- AFFINITY PURIFICATION OF SEQUENCESPECIFIC DNA BINDING PROTEINS (1986) (55)
- Bacteriophage SP01 regulatory proteins directing late gene transcription in vitro (1976) (55)
- RETRACTED: TAFIIs Mediate Activation of Transcription in the Drosophila Embryo (1996) (54)
- Purification of transcription cofactor complex CRSP. (1999) (54)
- An immunological assay for the sigma subunit of RNA polymerase in extracts of vegetative and sporulating Bacillus subtilis. (1974) (54)
- Cloning of Drosophila transcription factor Adf-1 reveals homology to Myb oncoproteins. (1992) (53)
- Transcription factor Sp1 recognizes promoter sequences from the monkey genome that are simian virus 40 promoter. (1985) (52)
- Analysis of clustered point mutations in the human ribosomal RNA gene promoter by transient expression in vivo. (1988) (51)
- Novel TRF1/BRF target genes revealed by genome‐wide analysis of Drosophila Pol III transcription (2007) (50)
- Targeting genes and transcription factors to segregated nuclear compartments. (2003) (48)
- Cofactor requirements for transcriptional activation by Sp1. (1998) (48)
- Translational control of SV40 T antigen expressed from the adenovirus late promoter (1983) (48)
- Molecular cloning and characterization of dTAFII30 alpha and dTAFII30 beta: two small subunits of Drosophila TFIID. (1993) (48)
- TAFIIs Mediate Activation of Transcription in the Drosophila Embryo (1998) (46)
- 3D ATAC-PALM: Super-resolution Imaging of the Accessible Genome (2020) (46)
- In vitro transcription of human ribosomal RNA genes by RNA polymerase I. (1982) (45)
- Rapid dynamics of general transcription factor TFIIB binding during preinitiation complex assembly revealed by single-molecule analysis (2016) (45)
- An interplay between TATA box-binding protein and transcription factors IIE and IIA modulates DNA binding and transcription. (1998) (44)
- A dynamic interplay of enhancer elements regulates Klf4 expression in naïve pluripotency (2017) (43)
- The dyskerin ribonucleoprotein complex as an OCT4/SOX2 coactivator in embryonic stem cells (2014) (43)
- Structural studies of the human PBAF chromatin-remodeling complex. (2005) (43)
- Sewage, Salt, Silica and SARS-CoV-2 (4S): An economical kit-free method for direct capture of SARS-CoV-2 RNA from wastewater. (2020) (43)
- Adf-1 Is a Nonmodular Transcription Factor That Contains a TAF-Binding Myb-Like Motif (1998) (42)
- Nucleosomes Impede Cas 9 Access to DNA in vivo and in vitro (2016) (42)
- The cell-type-specific activator region of c-Jun juxtaposes constitutive and negatively regulated domains. (1992) (40)
- Dual functions of TAF7L in adipocyte differentiation (2013) (39)
- Functional and mechanistic studies of XPC DNA-repair complex as transcriptional coactivator in embryonic stem cells (2015) (39)
- Ectopic expression of wild-type or a dominant-negative mutant of transcription factor NTF-1 disrupts normal Drosophila development. (1993) (39)
- In vitro transcription of a late class of phage SP01 genes (1975) (39)
- The transcription factor activity gradient (TAG) model: contemplating a contact-independent mechanism for enhancer–promoter communication (2021) (38)
- Imaging Transcription: Past, Present, and Future. (2015) (38)
- 28 Mechanisms of Transcriptional Control as Revealed by Studies of Human Transcription Factor Sp1 (1992) (38)
- dCas9-targeted locus-specific protein isolation method identifies histone gene regulators (2018) (37)
- Properties of simian virus 40 small t antigen overproduced in bacteria (1981) (37)
- Cell-type-selective induction of c-jun by TAF4b directs ovarian-specific transcription networks. (2006) (37)
- An adenovirus vector system used to express polyoma virus tumor antigens. (1985) (36)
- Chemical perturbation of an intrinsically disordered region of TFIID distinguishes two modes of transcription initiation (2015) (36)
- Transcriptional regulation by the AP-1 family of enhancer-binding proteins: a nuclear target for signal transduction. (1988) (36)
- Oligomeric structure of a simian virus 40 T antigen in free form and bound to DNA. (1981) (35)
- Mutational analysis of simian virus 40 large T antigen DNA binding sites. (1984) (35)
- Gene-specific transcriptional mechanisms at the histone gene cluster revealed by single-cell imaging. (2013) (34)
- Core promoter recognition complex changes accompany liver development (2011) (33)
- Wnt signaling targets ETO coactivation domain of TAF4/TFIID in vivo (2009) (33)
- Chloramphenicol restores sigma factor activity to sporulating Bacillus subtilis. (1974) (33)
- Core promoter factor TAF9B regulates neuronal gene expression (2014) (33)
- Regulation of viral transcription and DNA replication by the SV40 large T antigen. (1981) (32)
- Purification and comparative properties of the delta and sigma subunits of RNA polymerase from Bacillus subtilis. (1977) (30)
- Crystallographic study of the interaction of urea with lysozyme (1974) (30)
- REPLICATION IN MONKEY CELLS OF PLASMID DNA CONTAINING THE MINIMAL SV40 ORIGIN (1981) (30)
- Enhancer-promoter interactions and transcription are maintained upon acute loss of CTCF, cohesin, WAPL, and YY1 (2021) (29)
- Catalytic properties of the SV40 large T antigen. (1980) (28)
- An unexpected role of TAFs and TRFs in skeletal muscle differentiation: switching core promoter complexes. (2008) (27)
- Transcriptional activity of transcription factor IIE is dependent on zinc binding. (1994) (27)
- TAF7L modulates brown adipose tissue formation (2014) (27)
- A specific E3 ligase/deubiquitinase pair modulates TBP protein levels during muscle differentiation (2015) (27)
- Tuning levels of low-complexity domain interactions to modulate endogenous oncogenic transcription. (2022) (26)
- Cloning and properties of the Caenorhabditis elegans TATA-box-binding protein. (1993) (25)
- Drosophila TFIIA-S is up-regulated and required during Ras-mediated photoreceptor determination. (1996) (25)
- Coactivators and TAFs: a new class of eukaryotic transcription factors that connect activators to the basal machinery. (1993) (24)
- MEF2C and EBF1 Co-regulate B Cell-Specific Transcription (2016) (24)
- Sewage, Salt, Silica, and SARS-CoV-2 (4S): An Economical Kit-Free Method for Direct Capture of SARS-CoV-2 RNA from Wastewater (2021) (23)
- Transcriptional regulation in Drosophila: the post-genome challenge (2001) (23)
- Construction of adenovirus expression vectors by site-directed in vivo recombination. (1982) (23)
- Architecture of the human XPC DNA repair and stem cell coactivator complex (2015) (23)
- Inhibition of simian virus 40 DNA replication in vitro by poly(ADP-ribosyl)ated diadenosine tetraphosphate. (1987) (21)
- Transcriptional regulation by coactivators in embryonic stem cells. (2012) (21)
- The dTAFII80 subunit of Drosophila TFIID contains beta-transducin repeats. (1993) (20)
- Open-source RNA extraction and RT-qPCR methods for SARS-CoV-2 detection. (2021) (20)
- The tell-tail trigger (1992) (20)
- Myc-interacting protein 1 target gene profile: a link to microtubules, extracellular signal-regulated kinase, and cell growth. (2004) (20)
- Multiple control elements involved in the initiation of SV40 late transcription. (1984) (20)
- An RNA-binding region regulates CTCF clustering and chromatin looping (2018) (20)
- The genome of the choanoflagellate Monosiga brevicollis and the origins of metazoan multicellularity (2008) (19)
- Enhancer–promoter interactions and transcription are largely maintained upon acute loss of CTCF, cohesin, WAPL or YY1 (2022) (19)
- Tuning levels of low-complexity domain interactions to modulate endogenous oncogenic transcription (2021) (18)
- Transcription factor Spl recognizes promoter sequences from the monkey genome that are similar to the simian virus 40 promoter (18)
- Functional domain analysis of glass, a zinc-finger-containing transcription factor in Drosophila. (1995) (18)
- Regulation of DNA demethylation by the XPC DNA repair complex in somatic and pluripotent stem cells (2017) (18)
- Evidence for an Integrated Gene Repression Mechanism Based on mRNA Isoform Toggling in Human Cells (2018) (17)
- Recovering mixtures of fast-diffusing states from short single-particle trajectories (2021) (17)
- MeCP2 nuclear dynamics in live neurons results from low and high affinity chromatin interactions (2019) (17)
- Redundant Role of Tissue-Selective TAFII105 in B Lymphocytes (2002) (17)
- Is transcriptional regulation just going through a phase? (2021) (16)
- Affinity-purified antibody as a probe of RNA polymerase II subunit structure. (1984) (15)
- Does simian virus 40 T antigen unwind DNA? (1981) (15)
- Measuring dynamics of eukaryotic transcription initiation: Challenges, insights and opportunities (2017) (13)
- Reconstitution of TATA-binding protein-associated factor/TATA-binding protein complexes for in vitro transcription. (1996) (13)
- Structure of the human SAGA coactivator complex (2021) (12)
- BRD2 Compartmentalizes the Accessible Genome (2022) (12)
- "Structure"-function relationships in eukaryotic transcription factors: The role of intrinsically disordered regions in gene regulation. (2022) (11)
- Structure of the human SAGA coactivator complex: The divergent architecture of human SAGA allows modular coordination of transcription activation and co-transcriptional splicing (2021) (11)
- Mechanisms governing target search and binding dynamics of hypoxia-inducible factors (2021) (9)
- Inhibition of simian virus 40 DNA replication by specific modification of T-antigen with oxidized ATP. (1986) (9)
- Cross-species polymerase chain reaction: cloning of TATA box-binding proteins. (1993) (9)
- Retraction. TAF(II)s mediate activation of transcription in the Drosophila embryo. (1998) (9)
- Transcription Factor II--A Structure with Multiple Functions (1996) (8)
- Human TAF, 250 interacts with RAP74: implications . ... .. E or RNA polymerase I1 initiation (1995) (8)
- Sub-nuclear compartmentalization of core promoter factors and target genes (2011) (8)
- Structure and expression of two classes of mammalian homeo-box-containing genes. (1985) (7)
- Spot-On: robust model-based analysis of single-particle tracking experiments (2017) (7)
- Dynamic and Selective Low-Complexity Domain Interactions Revealed by Live-Cell Single-Molecule Imaging (2017) (7)
- Weak multivalent biomolecular interactions: a strength versus numbers tug of war with implications for phase partitioning (2021) (6)
- Super-resolution Imaging Reveals 3D Structure and Organizing Mechanism of Accessible Chromatin (2019) (6)
- Dual Mechanism of Rag Gene Repression by c-Myb during Pre-B Cell Proliferation (2017) (6)
- CHARACTERIZATION OF FACTORS THAT IMPART SELECTIVITY TO RNA POLYMERASE II IN A RECONSTITUTED SYSTEM (1981) (6)
- Inexpensive, versatile and open-source methods for SARS-CoV-2 detection (2020) (6)
- A Single-Molecule Surface-Based Platform to Detect the Assembly and Function of the Human RNA Polymerase II Transcription Machinery. (2020) (6)
- A New Focus on Plant Sciences (2010) (5)
- Not just Salk (2017) (5)
- The biochemistry of transcription and gene regulation. (1994) (5)
- Supporting biomedical research: meeting challenges and opportunities at HHMI. (2015) (5)
- Transient DNA Binding Induces RNA Polymerase II Compartmentalization During Herpesviral Infection Distinct From Phase Separation (2018) (5)
- Interaction of AD2+D2 protein and simian virus 40 large T antigen with the large tumor antigen binding site I. (1984) (5)
- Author response: 3D imaging of Sox2 enhancer clusters in embryonic stem cells (2014) (4)
- Simple, Inexpensive RNA Isolation and One‐Step RT‐qPCR Methods for SARS‐CoV‐2 Detection and General Use (2021) (4)
- Transcription. The tell-tail trigger. (1992) (4)
- Transcription enhancer sequences: a novel regulatory element (1982) (3)
- Architectural Features of 3D Genome Organization Revealed by Counting CTCF and Cohesin Molecules (2018) (3)
- Expression of SV40 Large T Antigen in Bacteria (1983) (3)
- Estimating Cellular Abundances of Halo-tagged Proteins in Live Mammalian Cells by Flow Cytometry. (2020) (3)
- selectivity and tissue-specific gene expression Diversified transcription initiation complexes expand promoter (2006) (2)
- POSITIVE CONTROL OF THE TEMPORAL PROGRAM OF BACTERIOPHAGE SP01 GENE EXPRESSION BY PHAGE AND HOST SPECIFIED SUBUNITS OF RNA POLYMERASE (1976) (2)
- Assessing Self-interaction of Mammalian Nuclear Proteins by Co-immunoprecipitation. (2020) (2)
- Author response: Nucleosomes impede Cas9 access to DNA in vivo and in vitro (2016) (2)
- BINDING OF D2 PROTEIN TO SPECIFIC PAPOVAVIRUS SEQUENCES (1980) (2)
- Mecanismo molecular del control génico (1995) (1)
- DPE-dependent versus TATA-dependent transcription TBP , Mot 1 , and NC 2 establish a regulatory circuit that controls Material Supplemental (2008) (1)
- Intrinsic and Associated Enzymatic Activities of SV40 Large T-Antigen (1979) (1)
- Author response: The dyskerin ribonucleoprotein complex as an OCT4/SOX2 coactivator in embryonic stem cells (2014) (1)
- Single-molecule tracking (SMT): a window into live-cell transcription biochemistry. (2023) (1)
- Transcription: The Never Ending Story (2006) (1)
- A nuclear traffic jam: unraveling multicomponent machines and compartments. (1996) (1)
- Author response: A specific E3 ligase/deubiquitinase pair modulates TBP protein levels during muscle differentiation (2015) (1)
- INHIBITION OF SV40 T ANTIGEN ENZYMATIC ACTIVITY BY A MONOSPECIFIC ANTIBODY (1979) (1)
- Rate accelerations by alteration in the orientation of reacting atoms. Comparison of lactonizations in bicyclo[2,2,2] and bicyclo[2,2,1] ring structures (1971) (1)
- Detecting molecular interactions in live-cell single-molecule imaging with proximity-assisted photoactivation (PAPA) (2022) (1)
- ISOLATION OF A NEW NONDEFECTIVE ADENOVIRUS-SV40 HYBRID VIRUS FROM IN VITRO CONSTRUCTED DEFECTIVE VIRUSES (1981) (0)
- Editorial Board (1995) (0)
- I. General Papers Ii. Applications 1. Mrna Target A. Dna Probe A. Rpl (0)
- Software Used For "Spot-On: Robust Model-Based Analysis Of Single-Particle Tracking Experiments" (2017) (0)
- COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY VOLUME LXXIII (2009) (0)
- Single-Molecule Insights on the Human RNA Polymerase II Transcription Regulation: Assembly of the Pre-Initiation Complex, Re-Initiation Scaffold, and the Roles of Activators (2012) (0)
- mRNA expression-mediated gene repression in human cells (2018) (0)
- Mechanisms of Eukaryotic Transcription : abstracts of papers presented at the Cold Spring Harbor Meeting on Cancer Cells, August 30-Spetember 3, 1995 (1995) (0)
- V.2 - Direct wastewater RNA capture and purification via the "Sewage, Salt, Silica and SARS-CoV-2 (4S)" method v2 (2020) (0)
- La transcription des gènes (1995) (0)
- Human core-PIC in the initial transcribing state (no IIS) (2016) (0)
- Proximity-assisted photoactivation (PAPA): Detecting molecular interactions in live-cell single-molecule imaging (2021) (0)
- Distinct Handoff Mechanism for TBP-TATA DNA Engagement Revealed by SAGA Structures. (2020) (0)
- 3D ATAC-PALM: super-resolution imaging of the accessible genome (2020) (0)
- Table of Contents (1995) (0)
- Cloning andexpression ofDrosophila TAF1,60 and humanTAFO170 reveal conserved interactions withother subunits ofTFIID (1993) (0)
- Editorial Board (1995) (0)
- Live cell single molecule imaging reveals concentration dependent changes to dynamic behavior of nuclear receptors RAR and RXR. (2023) (0)
- Assembly and Regulation of the Human RNA Polymerase II Preinitiation Complex: A Single-Molecule Approach to a Complex Biological System (2011) (0)
- human hsp 70 gene promoter . heat shock transcription factor , interact with a CCAAT-box-binding transcription factor and Two transcriptional activators (0)
- Single-Molecule Insights on Human RNA Polymerase II Transcription Regulation: Assembly of the Pre-Initiation Complex and the Roles of Activators (2013) (0)
- Daniel E. Koshland, Jr. 1902-2007. (2007) (0)
- Single-Molecule Studies of Human RNA Polymerase Ii Transcription Initiation: Core-Promoter Recognition (2011) (0)
- Electron Microscopy-FRET Imaging Localizes the C-Terminus of the Second TFIIF Subunit in RNA Polymerase II-TFIIF with Nanometer Precision (2013) (0)
- Mechanisms of MEF2C-Dependent Transcription in Lymphoid Differentiation (2014) (0)
- Author Index to Volume 228, April-June 1985 (1985) (0)
- Human core-PIC in the initial transcribing state (2016) (0)
- Human holo-PIC in the closed state (2016) (0)
- Dissecting the Macromolecular Machine that Decodes the Genome (2000) (0)
- Impaired cell fate through gain-of-function mutations in a chromatin reader (2019) (0)
- Author response: Single-molecule tracking of the transcription cycle by sub-second RNA detection (2013) (0)
- Daniel E. Koshland, Jr. 1920–2007 (2007) (0)
- Direct wastewater RNA capture and purification via the "Sewage, Salt, Silica and SARS-CoV-2 (4S)" method v1 (2020) (0)
- Author response: Real-time imaging of Huntingtin aggregates diverting target search and gene transcription (2016) (0)
- lkdecular Cloning and Functionai Anatysis of0 ila TAFI 10 Rev& Expec4ed of Coactiiators (1993) (0)
- Co−factor requirements for transcriptional activation by Sp1. Introductory Chapter (1999) (0)
- Purification and analysis of RNA polymerase II transcription factors by using wheat germ agglutinin affinity chromatography (transcription factor Spl/CCAAT-binding transcription factor/differential glycosylation/lectin binding/DNA affinity chromatography) (2016) (0)
- Mechanisms of Eukaryotic Transcription : Abstracts of papers presented at the Cold Spring Harbor Meeting on Cancer Cells, September 1-September 5, 1993 (1993) (0)
- tCyloning and express!on of AP-2, pe-speclnc transcription factor thCa 11" activates inducible enhancer elements (1988) (0)
- Regulation of SV40 Early Transcription (1984) (0)
- The Yamanaka factor Krüppel-like factor 4 ( KLF 4 ) is a (2017) (0)
- CRYSTAL STRUCTURE OF THE DOUBLE BROMODOMAIN MODULE FROM HUMAN TAFII250 (2000) (0)
- V.3 - Direct wastewater RNA capture and purification via the "Sewage, Salt, Silica and SARS-CoV-2 (4S)" method v3 (2020) (0)
- Author response: TAF7L modulates brown adipose tissue formation (2014) (0)
- Chemical Perturbation of an Intrinsically Disordered Region of TFIID Distinguishes de novo Transcription Initiation from Reinitiation (2016) (0)
- Abstracts of papers presented at the Cold Spring Harbor Meeting on Cancer Cells : regulation of eukaryotic mRNA transcription, September 6-September 10, 1989 (1989) (0)
- The future for Howard Hughes. Interview by Erika Check Hayden. (2008) (0)
- Human core-PIC in the open state (2016) (0)
- Human core TFIIH bound to DNA within the PIC (2016) (0)
- Terri and G&D: celebrating 50 years of enlightened scientific judgment (2023) (0)
- Structure/Function Analysis of the Metazoan Transcription Machinery Reveals Diversification and Specificity (2002) (0)
- Editorial Board (1995) (0)
- Eukaryotic Transcriptional Specificity Conferred by DNA-Binding Proteins (1987) (0)
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