Robert V. Farese Jr.
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Robert V. Farese Jr.'s Degrees
- PhD Biochemistry Stanford University
- Doctorate Medicine Stanford University
Why Is Robert V. Farese Jr. Influential?
(Suggest an Edit or Addition)According to Wikipedia, Robert V. Farese, Jr., is an American physician-scientist and professor of Cell Biology at the Sloan Kettering Institute of Memorial Sloan Kettering. He is an internationally recognized leader in the study of cellular lipid metabolism and has made seminal contributions to our understanding of energy storage as triglycerides in cellular organelles called lipid droplets.
Robert V. Farese Jr.'s Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Triglyceride accumulation protects against fatty acid-induced lipotoxicity (2003) (1686)
- Cellular fatty acid metabolism and cancer. (2013) (1335)
- Lipid droplets and cellular lipid metabolism. (2012) (1166)
- Suppression of Oxidative Stress by β-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor (2013) (1142)
- Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice. (1997) (1128)
- Mammalian Sir2 Homolog SIRT3 Regulates Global Mitochondrial Lysine Acetylation (2007) (1116)
- Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis. (1998) (1046)
- A dual thrombin receptor system for platelet activation (1998) (1023)
- Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat (2000) (881)
- SIRT 3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation (2010) (834)
- Lipid Droplets Finally Get a Little R-E-S-P-E-C-T (2009) (813)
- Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis. (2008) (796)
- SIRT3 regulates fatty acid oxidation via reversible enzyme deacetylation (2009) (766)
- Cloning of DGAT2, a Second Mammalian Diacylglycerol Acyltransferase, and Related Family Members* (2001) (735)
- The biophysics and cell biology of lipid droplets (2013) (727)
- SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. (2011) (671)
- Functional genomic screen reveals genes involved in lipid-droplet formation and utilization (2008) (655)
- A guide to analysis of mouse energy metabolism (2011) (641)
- Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing from the ER to lipid droplets. (2013) (601)
- Lipid Droplet Biogenesis. (2017) (537)
- Lipopenia and Skin Barrier Abnormalities in DGAT2-deficient Mice* (2004) (537)
- Role of the thrombin receptor in development and evidence for a second receptor (1996) (527)
- Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer. (2005) (527)
- Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver. (2007) (504)
- Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver. (2007) (504)
- Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation (2016) (488)
- FoxO1 Regulates Multiple Metabolic Pathways in the Liver (2006) (465)
- The life of lipid droplets. (2009) (460)
- Protein Kinase C-ζ as a Downstream Effector of Phosphatidylinositol 3-Kinase during Insulin Stimulation in Rat Adipocytes (1997) (408)
- Phosphatidylcholine synthesis for lipid droplet expansion is mediated by localized activation of CTP:phosphocholine cytidylyltransferase. (2011) (406)
- ACAT-2, A Second Mammalian Acyl-CoA:Cholesterol Acyltransferase (1998) (364)
- Lipid droplets at a glance (2009) (359)
- Balancing the fat: lipid droplets and human disease (2013) (358)
- Resistance to diet-induced hypercholesterolemia and gallstone formation in ACAT2-deficient mice (2000) (345)
- Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin (1996) (336)
- Lipid droplets and liver disease: from basic biology to clinical implications (2017) (318)
- The Endoplasmic Reticulum Enzyme DGAT2 Is Found in Mitochondria-associated Membranes and Has a Mitochondrial Targeting Signal That Promotes Its Association with Mitochondria* (2009) (315)
- Efficient Hepatitis C Virus Particle Formation Requires Diacylglycerol Acyltransferase 1 (DGAT1) (2010) (314)
- Increased insulin and leptin sensitivity in mice lacking acyl CoA:diacylglycerol acyltransferase 1. (2002) (300)
- Fatal Bilateral Chylothorax in Mice Lacking the Integrin α9β1 (2000) (287)
- Activation of Protein Kinase C (α, β, and ζ) by Insulin in 3T3/L1 Cells (1997) (280)
- Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKClambda/zeta. (2006) (278)
- Disruption of the acyl-CoA:cholesterol acyltransferase gene in mice: evidence suggesting multiple cholesterol esterification enzymes in mammals. (1996) (272)
- Licorice-induced hypermineralocorticoidism. (1991) (262)
- Seipin is required for converting nascent to mature lipid droplets (2016) (261)
- The triacylglycerol synthesis enzyme DGAT1 also catalyzes the synthesis of diacylglycerols, waxes, and retinyl esters Published, JLR Papers in Press, April 16, 2005. DOI 10.1194/jlr.M500036-JLR200 (2005) (256)
- Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury. (2012) (250)
- Increased atherosclerosis in LDL receptor-null mice lacking ACAT1 in macrophages. (2001) (250)
- Increased atherosclerosis in hyperlipidemic mice deficient in alpha -tocopherol transfer protein and vitamin E. (2000) (248)
- DGAT enzymes are required for triacylglycerol synthesis and lipid droplets in adipocytes[S] (2011) (243)
- Normal Development, Wound Healing, and Adenovirus Susceptibility in β5-Deficient Mice (2000) (240)
- Transgenic mice expressing high plasma concentrations of human apolipoprotein B100 and lipoprotein(a). (1993) (238)
- Knockout of the mouse apolipoprotein B gene results in embryonic lethality in homozygotes and protection against diet-induced hypercholesterolemia in heterozygotes. (1995) (238)
- DGAT1 Is Not Essential for Intestinal Triacylglycerol Absorption or Chylomicron Synthesis* (2002) (234)
- Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA:cholesterol acyltransferase 1. (2000) (226)
- Immunological quantitation and localization of ACAT-1 and ACAT-2 in human liver and small intestine. (2000) (222)
- Arf1/COPI machinery acts directly on lipid droplets and enables their connection to the ER for protein targeting (2013) (219)
- The FATP1–DGAT2 complex facilitates lipid droplet expansion at the ER–lipid droplet interface (2012) (218)
- Targeting Fat: Mechanisms of Protein Localization to Lipid Droplets. (2016) (213)
- Transgenic mice expressing high levels of human apolipoprotein B develop severe atherosclerotic lesions in response to a high-fat diet. (1995) (210)
- Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models (2012) (207)
- Activation of the ERK Pathway and Atypical Protein Kinase C Isoforms in Exercise- and Aminoimidazole-4-carboxamide- 1-β-d-riboside (AICAR)-stimulated Glucose Transport* (2002) (206)
- Activation of the ERK Pathway and Atypical Protein Kinase C Isoforms in Exercise- and Aminoimidazole-4-carboxamide- 1-β-d-riboside (AICAR)-stimulated Glucose Transport* (2002) (206)
- The problem of establishing relationships between hepatic steatosis and hepatic insulin resistance. (2012) (204)
- Mammalian acyl-CoA:cholesterol acyltransferases. (2000) (203)
- Insulin Activates Protein Kinases C-ζ and C-λ by an Autophosphorylation-dependent Mechanism and Stimulates Their Translocation to GLUT4 Vesicles and Other Membrane Fractions in Rat Adipocytes* (1999) (200)
- Membrane Topology and Identification of Key Functional Amino Acid Residues of Murine Acyl-CoA:Diacylglycerol Acyltransferase-2* (2006) (200)
- Lipid droplet biogenesis. (2014) (200)
- DGAT1-dependent triacylglycerol storage by macrophages protects mice from diet-induced insulin resistance and inflammation. (2010) (198)
- Deficiency of acyl CoA:cholesterol acyltransferase 2 prevents atherosclerosis in apolipoprotein E-deficient mice (2003) (193)
- Triglyceride Synthesis by DGAT1 Protects Adipocytes from Lipid-Induced ER Stress during Lipolysis. (2017) (192)
- Luteinizing hormone increases inositol trisphosphate and cytosolic free Ca2+ in isolated bovine luteal cells. (1987) (189)
- Progranulin Protects against Amyloid β Deposition and Toxicity in Alzheimer’s Disease Mouse Models (2014) (189)
- Myostatin modulates adipogenesis to generate adipocytes with favorable metabolic effects (2006) (189)
- Identification of a gene encoding MGAT1, a monoacylglycerol acyltransferase (2002) (186)
- Insulin-Sensitive Protein Kinases (Atypical Protein Kinase C and Protein Kinase B/Akt): Actions and Defects in Obesity and Type II Diabetes (2005) (179)
- Hepatic insulin signaling is required for obesity-dependent expression of SREBP-1c mRNA but not for feeding-dependent expression. (2012) (177)
- Activation of protein kinase C-zeta by insulin and phosphatidylinositol-3,4,5-(PO4)3 is defective in muscle in type 2 diabetes and impaired glucose tolerance: amelioration by rosiglitazone and exercise. (2003) (176)
- Introduction of human apolipoprotein E4 “domain interaction” into mouse apolipoprotein E (2001) (176)
- Tissue-specific regulation of lipoprotein lipase activity by insulin/glucose in normal-weight humans. (1991) (174)
- Function and dysfunction of aPKC isoforms for glucose transport in insulin-sensitive and insulin-resistant states. (2002) (174)
- Determination of adipocyte size by computer image analysis. (2002) (172)
- Insulin rapidly increases diacylglycerol by activating de novo phosphatidic acid synthesis. (1987) (170)
- MGAT2, a Monoacylglycerol Acyltransferase Expressed in the Small Intestine* (2003) (170)
- Prostaglandin F2 alpha stimulates phosphatidylinositol 4,5-bisphosphate hydrolysis and mobilizes intracellular Ca2+ in bovine luteal cells. (1987) (166)
- The Enzymes of Neutral Lipid Synthesis* (2001) (163)
- Inhibition of triglyceride synthesis as a treatment strategy for obesity: lessons from DGAT1-deficient mice. (2005) (162)
- Studies on the Substrate and Stereo/Regioselectivity of Adipose Triglyceride Lipase, Hormone-sensitive Lipase, and Diacylglycerol-O-acyltransferases* (2012) (161)
- Evidence for Involvement of Protein Kinase C (PKC)-ζ and Noninvolvement of Diacylglycerol-Sensitive PKCs in Insulin-Stimulated Glucose Transport in L6 Myotubes. (1997) (159)
- Knockout of PKCα enhances insulin signaling through PI3K (2002) (157)
- Targeted Disruption of the Mouse apobec-1 Gene Abolishes Apolipoprotein B mRNA Editing and Eliminates Apolipoprotein B48 (*) (1996) (156)
- Deficiency of the intestinal enzyme acyl CoA:monoacylglycerol acyltransferase-2 protects mice from metabolic disorders induced by high-fat feeding (2009) (154)
- Insulin increases membrane and cytosolic protein kinase C activity in BC3H-1 myocytes. (1987) (151)
- Chronic Activation of Protein Kinase C in Soleus Muscles and Other Tissues of Insulin-Resistant Type II diabetic Goto-Kakizaki (GK), Obese/Aged, and Obese/Zucker Rats: A Mechanism For Inhibiting Glycogen Synthesis (1996) (150)
- Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment. (2018) (150)
- A novel function for apolipoprotein B: lipoprotein synthesis in the yolk sac is critical for maternal-fetal lipid transport in mice. (1996) (147)
- Insulin and PIP3 activate PKC-zeta by mechanisms that are both dependent and independent of phosphorylation of activation loop (T410) and autophosphorylation (T560) sites. (2001) (145)
- In Vivo Metabolic Fingerprinting of Neutral Lipids with Hyperspectral Stimulated Raman Scattering Microscopy (2014) (143)
- Triglyceride synthesis: insights from the cloning of diacylglycerol acyltransferase. (2000) (143)
- Muscle-specific knockout of PKC-λ impairs glucose transport and induces metabolic and diabetic syndromes (2007) (142)
- Luteinizing hormone stimulates the formation of inositol trisphosphate and cyclic AMP in rat granulosa cells. Evidence for phospholipase C generated second messengers in the action of luteinizing hormone. (1986) (142)
- Angiopoietin-like 4 (ANGPTL4, Fasting-induced Adipose Factor) Is a Direct Glucocorticoid Receptor Target and Participates in Glucocorticoid-regulated Triglyceride Metabolism* (2009) (142)
- Angiotensin II rapidly increases phosphatidate-phosphoinositide synthesis and phosphoinositide hydrolysis and mobilizes intracellular calcium in cultured arterial muscle cells. (1984) (139)
- Compensation for PKMζ in long-term potentiation and spatial long-term memory in mutant mice (2016) (139)
- Specific role for acyl CoA:Diacylglycerol acyltransferase 1 (Dgat1) in hepatic steatosis due to exogenous fatty acids (2009) (139)
- Phenotypic analysis of mice expressing exclusively apolipoprotein B48 or apolipoprotein B100. (1996) (138)
- The Irs1 Branch of the Insulin Signaling Cascade Plays a Dominant Role in Hepatic Nutrient Homeostasis (2009) (138)
- Mechanism and Determinants of Amphipathic Helix-Containing Protein Targeting to Lipid Droplets. (2018) (138)
- Leptin modulates the effects of acyl CoA:diacylglycerol acyltransferase deficiency on murine fur and sebaceous glands. (2002) (136)
- Protein Correlation Profiles Identify Lipid Droplet Proteins with High Confidence* (2013) (134)
- Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids. (2019) (133)
- Dissociation of Frontotemporal Dementia–Related Deficits and Neuroinflammation in Progranulin Haploinsufficient Mice (2013) (132)
- A conserved role for atlastin GTPases in regulating lipid droplet size. (2013) (129)
- Dissociation of obesity and impaired glucose disposal in mice overexpressing acyl coenzyme a:diacylglycerol acyltransferase 1 in white adipose tissue. (2002) (129)
- Cholesterol metabolism and embryogenesis. (1998) (129)
- Functional Genomic Analyses Identify Pathways Dysregulated by Progranulin Deficiency, Implicating Wnt Signaling (2011) (128)
- DGAT1 mutation is linked to a congenital diarrheal disorder. (2012) (128)
- Cryo–electron microscopy structure of the lipid droplet–formation protein seipin (2018) (128)
- A lipid E-MAP identifies Ubx2 as a critical regulator of lipid saturation and lipid bilayer stress. (2013) (124)
- Plasma Cholesteryl Esters Provided by Lecithin:Cholesterol Acyltransferase and Acyl-Coenzyme A:Cholesterol Acyltransferase 2 Have Opposite Atherosclerotic Potential (2004) (124)
- Specific roles of the p110alpha isoform of phosphatidylinsositol 3-kinase in hepatic insulin signaling and metabolic regulation. (2010) (123)
- Effects of transiently expressed atypical (zeta, lambda), conventional (alpha, beta) and novel (delta, epsilon) protein kinase C isoforms on insulin-stimulated translocation of epitope-tagged GLUT4 glucose transporters in rat adipocytes: specific interchangeable effects of protein kinases C-zeta and (1999) (121)
- Downregulation of MicroRNA-9 in iPSC-Derived Neurons of FTD/ALS Patients with TDP-43 Mutations (2013) (121)
- Induced pluripotent stem cell models of progranulin-deficient frontotemporal dementia uncover specific reversible neuronal defects. (2012) (120)
- ACAT2 deficiency limits cholesterol absorption in the cholesterol‐fed mouse: Impact on hepatic cholesterol homeostasis (2004) (119)
- Protein Crowding Is a Determinant of Lipid Droplet Protein Composition. (2015) (116)
- The de novo phospholipid effect of insulin is associated with increases in diacylglycerol, but not inositol phosphates or cytosolic Ca2+. (1985) (116)
- A genetic model for absent chylomicron formation: mice producing apolipoprotein B in the liver, but not in the intestine. (1995) (114)
- A neurodegenerative disease mutation that accelerates the clearance of apoptotic cells (2011) (113)
- Diacylglycerol Acyltransferase-1 Localizes Hepatitis C Virus NS5A Protein to Lipid Droplets and Enhances NS5A Interaction with the Viral Capsid Core* (2013) (113)
- Gene expression profile of oxidant stress and neurodegeneration in transgenic mice deficient in alpha-tocopherol transfer protein. (2003) (110)
- LDAF1 and Seipin Form a Lipid Droplet Assembly Complex. (2019) (110)
- Protein Kinase C-ζ and Phosphoinositide-dependent Protein Kinase-1 Are Required for Insulin-induced Activation of ERK in Rat Adipocytes* (1999) (110)
- Effects of insulin and protein synthesis inhibitors on phospholipid metabolism, diacylglycerol levels, and pyruvate dehydrogenase activity in BC3H-1 cultured myocytes. (1984) (110)
- Atypical protein kinase C in insulin action and insulin resistance. (2005) (109)
- Phorbol ester provokes insulin-like effects on glucose transport, amino acid uptake, and pyruvate dehydrogenase activity in BC3H-1 cultured myocytes. (1985) (106)
- Suberoylanilide Hydroxamic Acid (Vorinostat) Up-regulates Progranulin Transcription (2011) (104)
- Effects of Insulin on Diacylglycerol–Protein Kinase C Signaling in Rat Diaphragm and Soleus Muscles and Relationship to Glucose Transport (1990) (104)
- Insulin activates protein kinases C-zeta and C-lambda by an autophosphorylation-dependent mechanism and stimulates their translocation to GLUT4 vesicles and other membrane fractions in rat adipocytes. (1999) (103)
- Effects of adenoviral gene transfer of wild-type, constitutively active, and kinase-defective protein kinase C-lambda on insulin-stimulated glucose transport in L6 myotubes. (2000) (101)
- DGAT and triglyceride synthesis: a new target for obesity treatment? (2000) (100)
- Incorporation of deuterated RRR- or all-rac-α-tocopherol in plasma and tissues of α-tocopherol transfer protein–null mice (2002) (98)
- Dependence of insulin-stimulated glucose transporter 4 translocation on 3-phosphoinositide-dependent protein kinase-1 and its target threonine-410 in the activation loop of protein kinase C-zeta. (1999) (95)
- Increased lipid accumulation and insulin resistance in transgenic mice expressing DGAT2 in glycolytic (type II) muscle. (2007) (95)
- Muscle-specific knockout of PKC-lambda impairs glucose transport and induces metabolic and diabetic syndromes. (2007) (95)
- Increased lipid accumulation and insulin resistance in transgenic mice expressing DGAT2 in glycolytic (type II) muscle. (2007) (95)
- Essential role of NAT1/p97/DAP5 in embryonic differentiation and the retinoic acid pathway (2000) (94)
- AICAR and metformin, but not exercise, increase muscle glucose transport through AMPK-, ERK-, and PDK1-dependent activation of atypical PKC. (2010) (94)
- Short-term overexpression of DGAT1 or DGAT2 increases hepatic triglyceride but not VLDL triglyceride or apoB production Published, JLR Papers in Press, July 30, 2006. (2006) (92)
- Activation and Translocation of Rho (and ADP Ribosylation Factor) by Insulin in Rat Adipocytes (1997) (91)
- Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD (2014) (91)
- Knockout of PKC alpha enhances insulin signaling through PI3K. (2002) (91)
- MicroRNA-29b Regulates the Expression Level of Human Progranulin, a Secreted Glycoprotein Implicated in Frontotemporal Dementia (2010) (89)
- Effects of transiently expressed atypical (ζ, λ), conventional (α, β) and novel (δ, ɛ) protein kinase C isoforms on insulin-stimulated translocation of epitope-tagged GLUT4 glucose transporters in rat adipocytes: specific interchangeable effects of protein kinases C-ζ and C-λ (1999) (89)
- Obesity resistance and enhanced glucose metabolism in mice transplanted with white adipose tissue lacking acyl CoA:diacylglycerol acyltransferase 1. (2003) (88)
- Regulation of Alternative Splicing of Protein Kinase Cβ by Insulin (*) (1995) (88)
- Activation of protein kinase C (alpha, beta, and zeta) by insulin in 3T3/L1 cells. Transfection studies suggest a role for PKC-zeta in glucose transport. (1997) (88)
- Retinol Esterification by DGAT1 Is Essential for Retinoid Homeostasis in Murine Skin* (2009) (86)
- Insulin acutely increases phospholipids in the phosphatidate-inositide cycle in rat adipose tissue. (1982) (86)
- Phosphoinositide metabolism and hormone action. (1983) (85)
- Insulin-induced Activation of Atypical Protein Kinase C, but Not Protein Kinase B, Is Maintained in Diabetic (ob/ob and Goto-Kakazaki) Liver (2004) (84)
- Evidence for involvement of protein kinase C (PKC)-zeta and noninvolvement of diacylglycerol-sensitive PKCs in insulin-stimulated glucose transport in L6 myotubes. (1997) (84)
- Insulin-induced Activation of Atypical Protein Kinase C, but Not Protein Kinase B, Is Maintained in Diabetic (ob/ob and Goto-Kakazaki) Liver (2004) (84)
- Microglial NFκB-TNFα hyperactivation induces obsessive–compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia (2017) (83)
- Progranulin Does Not Bind Tumor Necrosis Factor (TNF) Receptors and Is Not a Direct Regulator of TNF-Dependent Signaling or Bioactivity in Immune or Neuronal Cells (2013) (81)
- High confidence proteomic analysis of yeast LDs identifies additional droplet proteins and reveals connections to dolichol synthesis and sterol acetylation[S] (2014) (79)
- Insulin-induced activation of glycerol-3-phosphate acyltransferase by a chiro-inositol-containing insulin mediator is defective in adipocytes of insulin-resistant, type II diabetic, Goto-Kakizaki rats. (1994) (78)
- On the mechanism whereby ACTH and cyclic AMP increase adrenal polyphosphoinositides. Rapid stimulation of the synthesis of phosphatidic acid and derivatives of CDP - diacylglycerol. (1980) (75)
- Adrenocorticotropin acutely increases adrenal polyphosphoinositides. (1979) (75)
- Analysis of energy expenditure at different ambient temperatures in mice lacking DGAT1. (2003) (74)
- The GARP complex is required for cellular sphingolipid homeostasis (2015) (74)
- Effects of insulin on the translocation of protein kinase C-theta and other protein kinase C isoforms in rat skeletal muscles. (1995) (73)
- Rapid effects of angiotensin-II on polyphosphoinositide metabolism in the rat adrenal glomerulosa. (1984) (73)
- Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency (2020) (73)
- LPA3 receptor mediates chemotaxis of immature murine dendritic cells to unsaturated lysophosphatidic acid (LPA) (2007) (73)
- Are polyphosphoinositides the cycloheximide-sensitive mediator in the steroidogenic actions of adrenocorticotropin and adenosine-3',5'-monophosphate? (1980) (72)
- The triglyceride synthesis enzymes DGAT1 and DGAT2 have distinct and overlapping functions in adipocytes[S] (2019) (72)
- Polyphosphoinositides:stimulator of mitochondrial cholesterol side chain cleavage and possible identification as an adrenocorticotropin-induced, cycloheximide-sensitive, cytosolic, steroidogenic factor. (1980) (72)
- Metabolic functions of atypical protein kinase C: "good" and "bad" as defined by nutritional status. (2010) (72)
- PKC-zeta mediates insulin effects on glucose transport in cultured preadipocyte-derived human adipocytes. (2002) (71)
- Thiazolidinedione Treatment Enhances Insulin Effects on Protein Kinase C-ζ/λ Activation and Glucose Transport in Adipocytes of Nondiabetic and Goto-Kakizaki Type II Diabetic Rats* (2000) (71)
- Progranulin: at the interface of neurodegenerative and metabolic diseases (2013) (71)
- Mechanisms whereby insulin increases diacylglycerol in BC3H-1 myocytes. (1988) (71)
- Effects of Knockout of the Protein Kinase C β Gene on Glucose Transport and Glucose Homeostasis1. (1999) (70)
- Effects of insulin and phorbol esters on subcellular distribution of protein kinase C isoforms in rat adipocytes. (1992) (69)
- Glucose activates protein kinase C-zeta /lambda through proline-rich tyrosine kinase-2, extracellular signal-regulated kinase, and phospholipase D: a novel mechanism for activating glucose transporter translocation. (2001) (68)
- OBSERVATIONS ON THE INTERRELATIONS BETWEEN ADRENAL PROTEIN, RNA AND DNA DURING PROLONGED ACTH ADMINISTRATION. (1963) (67)
- Insulin stimulates the translocation of protein kinase C in rat adipocytes (1989) (67)
- Skeletal muscle insulin resistance in obesity-associated type 2 diabetes in monkeys is linked to a defect in insulin activation of protein kinase C-zeta/lambda/iota. (2002) (67)
- Tissue expression studies on the mouse acyl-CoA: cholesterol acyltransferase gene (Acact): findings supporting the existence of multiple cholesterol esterification enzymes in mice. (1997) (67)
- The critical role of atypical protein kinase C in activating hepatic SREBP-1c and NFkappaB in obesity. (2009) (66)
- Gonadotropin-releasing hormone (GnRH) rapidly stimulates the formation of inositol phosphates and diacyglycerol in rat granulosa cells: further evidence for the involvement of Ca2+ and protein kinase C in the action of GnRH. (1986) (66)
- The phosphatidylinositol 3-kinase inhibitor, wortmannin, inhibits insulin-induced activation of phosphatidylcholine hydrolysis and associated protein kinase C translocation in rat adipocytes. (1996) (66)
- Genetic regulation of cholesterol homeostasis: chromosomal organization of candidate genes. (1996) (66)
- SnapShot: Lipid Droplets (2009) (65)
- Insulin signalling downstream of protein kinase B is potentiated by 5′AMP-activated protein kinase in rat hearts in vivo (2005) (65)
- DGAT enzymes and triacylglycerol biosynthesis (2008) (64)
- Apolipoprotein B-related gene expression and ultrastructural characteristics of lipoprotein secretion in mouse yolk sac during embryonic development. (1999) (64)
- Okadaic acid activates atypical protein kinase C (zeta/lambda) in rat and 3T3/L1 adipocytes. An apparent requirement for activation of Glut4 translocation and glucose transport. (1999) (64)
- Glucose Activates Mitogen-activated Protein Kinase (Extracellular Signal-regulated Kinase) through Proline-rich Tyrosine Kinase-2 and the Glut1 Glucose Transporter* (2000) (64)
- Dual activation of the inositol-triphosphate-calcium and cyclic nucleotide intracellular signaling systems by adrenocorticotropin in rat adrenal cells. (1986) (63)
- Phospholipids as intermediates in hormone action (1984) (63)
- Insulin-Sensitive Phospholipid Signaling Systems and Glucose Transport: An Update 1 (1996) (63)
- Frontotemporal degeneration, the next therapeutic frontier: Molecules and animal models for frontotemporal degeneration drug development (2013) (62)
- Similarities between effects of adenosine 3',5'-monophosphate and guanosine 3' 5'-monophosphate on liver and adrenal metabolism. (1969) (62)
- SIRT 3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome (2011) (62)
- Role of atypical protein kinase C in activation of sterol regulatory element binding protein-1c and nuclear factor kappa B (NFκB) in liver of rodents used as a model of diabetes, and relationships to hyperlipidaemia and insulin resistance (2009) (61)
- Insulin-sensitive phospholipid signaling systems and glucose transport: an update. (1996) (61)
- Insulin activates glycerol-3-phosphate acyltransferase (de novo phosphatidic acid synthesis) through a phospholipid-derived mediator. Apparent involvement of Gi alpha and activation of a phospholipase C. (1990) (61)
- Comparative Effects of GTPγS and Insulin on the Activation of Rho, Phosphatidylinositol 3-Kinase, and Protein Kinase N in Rat Adipocytes (1998) (61)
- Protein kinase C-lambda knockout in embryonic stem cells and adipocytes impairs insulin-stimulated glucose transport. (2004) (60)
- Glucose‐induced synthesis of diacylglycerol de novo is associated with translocation (activation) of protein kinase C in rat adipocytes (1989) (59)
- Role of protein kinase C in insulin's regulation of c-fos transcription. (1992) (59)
- Development of the mammary gland requires DGAT1 expression in stromal and epithelial tissues (2004) (59)
- A human skin multifunctional O-acyltransferase that catalyzes the synthesis of acylglycerols, waxes, and retinyl esters Published, JLR Papers in Press, August 16, 2005. DOI 10.1194/jlr.M500168-JLR200 (2005) (58)
- DGAT1 promoter polymorphism associated with alterations in body mass index, high density lipoprotein levels and blood pressure in Turkish women (2002) (58)
- Cardiomyocyte-specific Loss of Diacylglycerol Acyltransferase 1 (DGAT1) Reproduces the Abnormalities in Lipids Found in Severe Heart Failure* (2014) (58)
- Brain Insulin Signaling Is Increased in Insulin-Resistant States and Decreases in FOXOs and PGC-1α and Increases in Aβ1–40/42 and Phospho-Tau May Abet Alzheimer Development (2016) (57)
- Immunolocalization of Acyl-Coenzyme A:CholesterolO-Acyltransferase in Macrophages* (1998) (57)
- Cholesterol Esterification by Host and Parasite Is Essential for Optimal Proliferation of Toxoplasma gondii * (2001) (56)
- Secretin induces rapid increases in inositol trisphosphate, cytosolic Ca2+ and diacylglycerol as well as cyclic AMP in rat pancreatic acini. (1986) (55)
- Taming the sphinx: Mechanisms of cellular sphingolipid homeostasis. (2016) (55)
- Mass Spectrometry – Based Proteomics and Network Biology (2013) (55)
- Repletion of Atypical Protein Kinase C following RNA Interference-mediated Depletion Restores Insulin-stimulated Glucose Transport* (2006) (54)
- Insulin-induced glycerolipid mediators and the stimulation of glucose transport in BC3H-1 myocytes. (1988) (53)
- Role of adipocyte-derived factors in enhancing insulin signaling in skeletal muscle and white adipose tissue of mice lacking Acyl CoA:diacylglycerol acyltransferase 1. (2004) (53)
- Insulin stimulates phospholipase D-dependent phosphatidylcholine hydrolysis, Rho translocation, de novo phospholipid synthesis, and diacylglycerol/protein kinase C signaling in L6 myotubes. (1996) (53)
- Mechanisms for increased insulin-stimulated Akt phosphorylation and glucose uptake in fast- and slow-twitch skeletal muscles of calorie-restricted rats. (2011) (53)
- Role of adipocyte-derived factors in enhancing insulin signaling in skeletal muscle and white adipose tissue of mice lacking Acyl CoA:diacylglycerol acyltransferase 1. (2004) (53)
- Hepatocyte Deletion of Triglyceride‐Synthesis Enzyme Acyl CoA: Diacylglycerol Acyltransferase 2 Reduces Steatosis Without Increasing Inflammation or Fibrosis in Mice (2019) (52)
- Sorbitol activates atypical protein kinase C and GLUT4 glucose transporter translocation/glucose transport through proline-rich tyrosine kinase-2, the extracellular signal-regulated kinase pathway and phospholipase D. (2002) (52)
- Adrenocorticotrophin-induced changes in the steroidogenic activity of adrenal cell-free preparations. (1967) (52)
- Hepatitis C Virus Core Protein Decreases Lipid Droplet Turnover (2011) (51)
- Parathyroid hormone acutely increases polyphosphoinositides of the rabbit kidney cortex by a cycloheximide-sensitive process. (1980) (51)
- Metformin improves atypical protein kinase C activation by insulin and phosphatidylinositol-3,4,5-(PO4)3 in muscle of diabetic subjects (2006) (51)
- Partitioning of MLX-Family Transcription Factors to Lipid Droplets Regulates Metabolic Gene Expression. (2020) (51)
- Insulin provokes a transient activation of phospholipase C in the rat epididymal fat pad. (1986) (51)
- Stimulation of phospholipid labeling and steroidogenesis by luteinizing hormone in isolated bovine luteal cells. (1981) (50)
- Studies with wortmannin suggest a role for phosphatidylinositol 3-kinase in the activation of glycogen synthase and mitogen-activated protein kinase by insulin in rat adipocytes: comparison of insulin and protein kinase C modulators. (1995) (50)
- Effects of angiotensin II, K+, adrenocorticotropin, serotonin, adenosine 3',5'-monophosphate, guanosine 3',5'-monophosphate, A23187, and EGTA on aldosterone synthesis and phospholipid metabolism in the rat adrenal zona glomerulosa. (1983) (50)
- Comparison of effects of adrenocorticotropin and Lys-gamma 3-melanocyte-stimulating hormone on steroidogenesis, adenosine 3',5'-monophosphate production, and phospholipid metabolism in rat adrenal fasciculata-reticularis cells in vitro. (1983) (49)
- The phosphatidate-phosphoinositide cycle: an intracellular messenger system in the action of hormones and neurotransmitters. (1983) (49)
- Retention of specific protein kinase C isozymes following chronic phorbol ester treatment in BC3H-1 myocytes. (1989) (49)
- The advantages of frontotemporal degeneration drug development (part 2 of frontotemporal degeneration: The next therapeutic frontier) (2013) (49)
- A novel PKC-ι inhibitor abrogates cell proliferation and induces apoptosis in neuroblastoma. (2011) (49)
- Insulin increases the synthesis of phospholipid and diacylglycerol and protein kinase C activity in rat hepatocytes. (1990) (48)
- Apolipoprotein B gene mutations affecting cholesterol levels (1992) (48)
- An open-access volume electron microscopy atlas of whole cells and tissues (2020) (47)
- Hepatic insulin resistance in ob/ob mice involves increases in ceramide, aPKC activity, and selective impairment of Akt-dependent FoxO1 phosphorylation (2015) (47)
- The role of protein kinase C in insulin action. (1992) (46)
- Defective activation of atypical protein kinase C zeta and lambda by insulin and phosphatidylinositol-3,4,5-(PO4)(3) in skeletal muscle of rats following high-fat feeding and streptozotocin-induced diabetes. (2003) (46)
- Protein kinase C inhibitors block insulin and PMA-stimulated hexose transport in isolated rat adipocytes and BC3H-1 myocytes. (1990) (46)
- Rosiglitazone, Insulin Treatment, and Fasting Correct Defective Activation of Protein Kinase C-ζ/λ by Insulin in Vastus Lateralis Muscles and Adipocytes of Diabetic Rats. (2001) (46)
- Parathyroid hormone and adenosine-3',5'-monophosphate acutely increase phospholipids of the phosphatidate-polyphosphoinositide pathway in rabbit kidney cortex tubules in vitro by a cycloheximide-sensitive process. (1981) (46)
- Effects of knockout of the protein kinase C beta gene on glucose transport and glucose homeostasis. (1999) (45)
- Increased atypical PKC activity in endurance-trained human skeletal muscle. (2003) (45)
- Rapid glucose-dependent increases in phosphatidic acid and phosphoinositides in rat pancreatic islets. (1986) (45)
- Steroid hormones: Interactions with membrane-bound receptors (1999) (44)
- Calcium as a Mediator of Adrenocorticotrophic Hormone Action on Adrenal Protein Synthesis (1971) (44)
- Interrelated effects of insulin and glucose on diacylglycerol-protein kinase-C signalling in rat adipocytes and solei muscle in vitro and in vivo in diabetic rats. (1991) (44)
- Effects of angiotensin-II and potassium on phospholipid metabolism in the adrenal zona glomerulosa. (1981) (44)
- Murine knockin model for progranulin-deficient frontotemporal dementia with nonsense-mediated mRNA decay (2018) (43)
- Effects of luteinizing hormone on phosphoinositide metabolism in rat granulosa cells. (1984) (43)
- Insulin increases mRNA levels of protein kinase C-alpha and -beta in rat adipocytes and protein kinase C-alpha, -beta and -theta in rat skeletal muscle. (1995) (42)
- Differential effect of bicycling exercise intensity on activity and phosphorylation of atypical protein kinase C and extracellular signal‐regulated protein kinase in skeletal muscle (2004) (42)
- Cbl, IRS-1, and IRS-2 Mediate Effects of Rosiglitazone on PI3K, PKC-λ, and Glucose Transport in 3T3/L1 Adipocytes. (2002) (42)
- In vivo chiro-inositol metabolism in the rat: a defect in chiro-inositol synthesis from myo-inositol and an increased incorporation of chiro-[3H]inositol into phospholipid in the Goto-Kakizaki (G.K) rat. (1998) (42)
- INHIBITION OF THE STEROIDOGENIC EFFECT OF ACTH AND INCORPORATION OF AMINO ACID INTO RAT ADRENAL PROTEIN IN VITRO BY CHLORAMPHENICOL. (1964) (41)
- Exercise improves phosphatidylinositol‐3,4,5‐trisphosphate responsiveness of atypical protein kinase C and interacts with insulin signalling to peptide elongation in human skeletal muscle (2007) (41)
- Insulin-Sensitive Phospholipid Signaling Systems and Glucose Transport. Update II 1 (2001) (41)
- Polyphosphorylated glycerolipids mimic adrenocorticotropin-induced stimulation of mitochondrial pregnenolone-synthesis. (1979) (40)
- Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice (2012) (40)
- Tissue-specific differences in activation of atypical protein kinase C and protein kinase B in muscle, liver, and adipocytes of insulin receptor substrate-1 knockout mice. (2004) (40)
- Acyl CoA:cholesterol acyltransferase genes and knockout mice. (1998) (39)
- Immunological evidence that insulin activates protein kinase C in BC3H‐1 myocytes (1989) (39)
- Nephrogenic diabetes insipidus associated with foscarnet treatment of cytomegalovirus retinitis. (1990) (37)
- Structure and catalytic mechanism of a human triglyceride synthesis enzyme (2020) (37)
- Lipid Droplets in Brown Adipose Tissue Are Dispensable for Cold-Induced Thermogenesis (2020) (37)
- Incorporation of deuterated RRR- or all-rac-alpha-tocopherol in plasma and tissues of alpha-tocopherol transfer protein--null mice. (2002) (37)
- Potassium and angiotensin II increase the concentrations of phosphatidic acid, phosphatidylinositol, and polyphosphoinositides in rat adrenal capsules in vitro. (1980) (37)
- On the requirement for calcium during the steroidogenic effect of ACTH. (1971) (36)
- The in vitro red blood cell uptake of C-14-cortisol; studies of plasma protein binding of cortisol in normal and abnormal states. (1962) (36)
- Effects of carbachol and pancreozymin (cholecystokinin-octapeptide) on polyphosphoinositide metabolism in the rat pancreas in vitro. (1984) (36)
- Phospholipid signaling systems in insulin action. (1988) (36)
- The nine lives of ACAT inhibitors. (2006) (36)
- Rat Leydig cell phospholipid content is increased by luteinizing hormone and 8-bromo-cyclic AMP. (1982) (35)
- Tissue-specific knockouts of ACAT2 reveal that intestinal depletion is sufficient to prevent diet-induced cholesterol accumulation in the liver and blood[S] (2012) (35)
- Cholesterol homeostasis: A role for oxysterols (1998) (35)
- Effect of Adrenocorticotrophin on Adrenal Protein Synthesis1 (1963) (34)
- Insulin-like effects of epidermal growth factor and insulin-like growth factor-I on [3H]2-deoxyglucose uptake, diacylglycerol generation and protein kinase C activation in BC3H-1 myocytes. (1989) (33)
- A truncated species of apolipoprotein B, B-83, associated with hypobetalipoproteinemia. (1992) (33)
- Regulation of alternative splicing of protein kinase C beta by insulin. (1995) (33)
- Deficiency of acyl coenzyme a:diacylglycerol acyltransferase 1 increases leptin sensitivity in murine obesity models. (2002) (33)
- Downregulation of Adiponectin/AdipoR2 is Associated with Steatohepatitis in Obese Mice (2009) (33)
- The Hepatitis C Virus Core Protein Inhibits Adipose Triglyceride Lipase (ATGL)-mediated Lipid Mobilization and Enhances the ATGL Interaction with Comparative Gene Identification 58 (CGI-58) and Lipid Droplets* (2014) (33)
- Gonadotropin-releasing hormone (GnRH) stimulates phosphatidylinositol metabolism in rat granulosa cells: mechanism of action of GnRH. (1983) (33)
- RO 31-8220 activates c-Jun N-terminal kinase and glycogen synthase in rat adipocytes and L6 myotubes. Comparison to actions of insulin. (1999) (32)
- An 8-week, open-label, dose-finding study of nimodipine for the treatment of progranulin insufficiency from GRN gene mutations (2017) (32)
- On the role of calcium in adrenocorticotropin-induced changes in mitochondrial pregnenolone synthesis. (1978) (32)
- Correction of metabolic abnormalities in a rodent model of obesity, metabolic syndrome, and type 2 diabetes mellitus by inhibitors of hepatic protein kinase C-ι. (2012) (32)
- Downregulation of Protein Kinase C and Insulin-Stimulated 2-Deoxyglucose Uptake in Rat Adipocytes by Phorbol Esters, Glucose, and Insulin (1991) (32)
- Cholesterol, hedgehog and embryogenesis (1997) (31)
- Effects of insulin and phorbol esters on diacylglycerol generation and synthesis and hydrolysis of phosphatidylcholine in BC3H-1 myocytes. (1988) (30)
- Effects of DGAT1 deficiency on energy and glucose metabolism are independent of adiponectin. (2006) (30)
- Functional Contribution of the Spastic Paraplegia-Related Triglyceride Hydrolase DDHD2 to the Formation and Content of Lipid Droplets. (2017) (30)
- Akt-Dependent Phosphorylation of Hepatic FoxO1 Is Compartmentalized on a WD40/ProF Scaffold and Is Selectively Inhibited by aPKC in Early Phases of Diet-Induced Obesity (2014) (30)
- Angiopoietin-like 4 (ANGPTL4, fasting-induced adipose factor) is a direct glucocorticoid receptor target and participates in glucocorticoid-regulated triglyceride metabolism. (2012) (30)
- Epidermal growth factor and insulin-like growth factor I stimulate the hydrolysis of the insulin-sensitive phosphatidylinositol-glycan in BC3H-1 myocytes. (1988) (29)
- Insulin and Its Secretagogues Activate Ca2+-dependent Phosphatidylinositol Breakdown and Amylase Secretion in Rat Pancreas In Vitro (1981) (29)
- Rab18 is not necessary for lipid droplet biogenesis or turnover in human mammary carcinoma cells (2018) (29)
- Effects of insulin on diacylglycerol/protein kinase-C signalling and glucose transport in rat skeletal muscles in vivo and in vitro. (1992) (29)
- Human chorionic gonadotropin activates the inositol 1,4,5‐trisphosphate‐Ca2+ intracellular signalling system in bovine luteal cells (1986) (29)
- Sulfonylurea-Stimulated Glucose Transport Association With Diacylglycerollike Activation of Protein Kinase C in BC3H1 Myocytes (1990) (29)
- Effects of Ca2+ ionophore A23187 and Ca2+ deficiency on pancreatic phospholipids and amylase release in vitro. (1980) (29)
- Speech Perception in Infants (1971) (29)
- Differential down-regulation of insulin-sensitive protein kinase-C isoforms by 12-O-tetradecanoylphorbol-13-acetate in rat adipocytes and BC3H-1 myocytes. (1993) (28)
- Ca2+-dependent and Ca2+-independent effects of pancreatic secretagogues on phosphatidylinositol metabolism. (1982) (27)
- Insulin resistance for glucose uptake and Akt2 phosphorylation in the soleus, but not epitrochlearis, muscles of old vs. adult rats. (2010) (27)
- Stimulation of phospholipid synthesis by luteinizing hormone in isolated rat granulosa cells. (1983) (27)
- Secreted Progranulin Is a Homodimer and Is Not a Component of High Density Lipoproteins (HDL)* (2013) (26)
- Turning WAT into BAT gets rid of fat (2001) (26)
- Inactivation of the Integrin [36 Subunit Gene Reveals a Role of Epithelial Integrins in Regulating Inflammation in the Lungs and Skin (2002) (26)
- Effects of insulin and phorbol esters on MARCKS (myristoylated alanine-rich C-kinase substrate) phosphorylation (and other parameters of protein kinase C activation) in rat adipocytes, rat soleus muscle and BC3H-1 myocytes. (1993) (26)
- Pharmacological TLR4 Inhibition Protects against Acute and Chronic Fat-Induced Insulin Resistance in Rats (2015) (26)
- The LDL receptor gene family, apolipoprotein B and cholesterol in embryonic development. (1999) (26)
- Identification and characterization of a novel DGAT1 missense mutation associated with congenital diarrhea[S] (2017) (25)
- Rosiglitazone, insulin treatment, and fasting correct defective activation of protein kinase C-zeta/lambda by insulin in vastus lateralis muscles and adipocytes of diabetic rats. (2001) (25)
- Determinants of Endoplasmic Reticulum-to-Lipid Droplet Protein Targeting. (2020) (25)
- Insulin signalling in hepatocytes of humans with type 2 diabetes: excessive production and activity of protein kinase C-ι (PKC-ι) and dependent processes and reversal by PKC-ι inhibitors (2012) (25)
- Lipid droplets go nuclear (2016) (25)
- Impaired activation of protein kinase C-zeta by insulin and phosphatidylinositol-3,4,5-(PO4)3 in cultured preadipocyte-derived adipocytes and myotubes of obese subjects. (2004) (25)
- Effects of adrenocorticotropin and cycloheximide on adrenal diglyceride kinase. (1981) (25)
- Cbl, IRS-1, and IRS-2 mediate effects of rosiglitazone on PI3K, PKC-lambda, and glucose transport in 3T3/L1 adipocytes. (2002) (25)
- Prolactin and known modulators of rat splenocytes activate nuclear protein kinase C. (1990) (25)
- Insulin provokes co-ordinated increases in the synthesis of phosphatidylinositol, phosphatidylinositol phosphates and the phosphatidylinositol-glycan in BC3H-1 myocytes. (1988) (24)
- Sulfonylureas activate glucose transport and protein kinase C in rat adipocytes. (1991) (24)
- Metformin action in human hepatocytes: coactivation of atypical protein kinase C alters 5′-AMP-activated protein kinase effects on lipogenic and gluconeogenic enzyme expression (2013) (24)
- FIT2 is an acyl–coenzyme A diphosphatase crucial for endoplasmic reticulum homeostasis (2020) (24)
- Mogat1 deletion does not ameliorate hepatic steatosis in lipodystrophic (Agpat2−/−) or obese (ob/ob) mice (2016) (24)
- Insulin but not phorbol ester treatment increases phosphorylation of vinculin by protein kinase C in BC3H‐1 myocytes (1987) (24)
- Stimulation of pregnenolone synthesis by ACTH in rat adrenal sections. (1971) (24)
- Four new mutations in the apolipoprotein B gene causing hypobetalipoproteinemia, including two different frameshift mutations that yield truncated apolipoprotein B proteins of identical length. (1993) (24)
- Elevated atrial natriuretic peptides and early renal failure in type 2 diabetic Goto-Kakizaki rats. (1999) (23)
- TRANSFECTION STUDIES SUGGEST A ROLE FOR PKC-z IN GLUCOSE TRANSPORT* (1997) (23)
- ACTH stimulates turnover of the phosphatidylinositol-glycan. (1988) (23)
- Inhibition of sphingolipid synthesis improves outcomes and survival in GARP mutant wobbler mice, a model of motor neuron degeneration (2020) (22)
- Insulin stimulates novel protein kinase C in rat adipocytes. (1992) (22)
- On the requirement for protein synthesis during corticotropin-induced stimulation of cholesterol side chain cleavage in rat adrenal mitochondrial and solubilized desmolase preparations. (1977) (22)
- Adrenocorticotropin and adenosine 3',5'-monophosphate stimulate de novo synthesis of adrenal phosphatidic acid by a cycloheximide-sensitive, CA++-dependent mechanism. (1981) (22)
- Insulin rapidly increases glycerol-3-phosphate-acyltransferase activity in rat adipocytes. (1991) (22)
- Treatment of primary cultures of calf adrenal glomerulosa cells with adrenocorticotropin (ACTH) and phorbol esters: a comparative study of the effects on aldosterone production and ACTH signaling system. (1990) (22)
- Potential role of phospholipid-signaling systems in insulin action and states of clinical insulin resistance. (1989) (22)
- FURTHER STUDIES ON THE STIMULATION OF ADRENAL PROTEIN SYNTHESIS BY ACTH: AN EFFECT ON MICROSOMES AND RIBOSOMES. (1964) (21)
- Essential role of protein kinase Cζ in the impairment of insulin‐induced glucose transport in IRS‐2‐deficient brown adipocytes (2003) (21)
- Thiazolidinedione treatment enhances insulin effects on protein kinase C-zeta /lambda activation and glucose transport in adipocytes of nondiabetic and Goto-Kakizaki type II diabetic rats. (2000) (21)
- Requirements for Pseudosubstrate Arginine Residues during Autoinhibition and Phosphatidylinositol 3,4,5-(PO4)3-dependent Activation of Atypical PKC* (2014) (21)
- Protein kinase C activation patterns are determined by methodological variations. Studies of insulin action in BC3H-1 myocytes and rat adipose tissue. (1990) (21)
- Effects of insulin on protein kinase-C (PKC) in HIRC-B cells: specific activation of PKC epsilon and its resistance to phorbol ester-induced down-regulation. (1994) (21)
- A23187 inhibits adrenal protein synthesis and the effects of adrenocorticotropin (ACTH) on steroidogenesis and phospholipid metabolism in rat adrenal cells in vitro: further evidence implicating phospholipids in the steroidogenic action of ACTH. (1981) (20)
- Insulin substrates 1 and 2 are corequired for activation of atypical protein kinase C and Cbl-dependent phosphatidylinositol 3-kinase during insulin action in immortalized brown adipocytes. (2004) (20)
- ACTH increases diacylglycerol content and subcellular redistribution of protein kinase C in the rat adrenal in vivo. (1987) (20)
- Requirements for pYXXM motifs in Cbl for binding to the p85 subunit of phosphatidylinositol 3-kinase and Crk, and activation of atypical protein kinase C and glucose transport during insulin action in 3T3/L1 adipocytes. (2004) (20)
- Gonadotropin-releasing hormone rapidly alters polyphosphoinositide metabolism in rat granulosa cells. (1984) (20)
- Lipid-Derived Mediators in Insulin Action (1990) (20)
- Atypical protein kinase C activity in the hypothalamus is required for lipopolysaccharide-mediated sickness responses. (2009) (20)
- Effects of actinomycin D on ACTH-induced corticosteroidogenesis. (1966) (20)
- Antisense DNA downregulates protein kinase C isozymes (beta and alpha) and insulin-stimulated 2-deoxyglucose uptake in rat adipocytes. (1991) (19)
- Transgenic mice expressing human apoB100 and apoB48. (1994) (19)
- Effects of ACTH on Adrenal RNA Synthesis1 (1967) (19)
- Fatty acids, triglycerides, and glucose metabolism: recent insights from knockout mice (2002) (19)
- Insulin treatment acutely increases the concentration of phosphatidylserine in rat adipose tissue. (1983) (19)
- Comparison of changes in inositide and noninositide phospholipids during acute and prolonged adrenocorticotropic hormone treatment in vivo. (1982) (18)
- Defective Activation of Protein Kinase C-z in Muscle by Insulin and Phosphatidylinositol-3,4,5,-(PO(4))(3) in Obesity and Polycystic Ovary Syndrome. (2004) (18)
- Impaired skeletal muscle glycogen synthase activation by insulin in the Goto-Kakizaki (G/K) rat (1994) (18)
- The Mechanism of Action of Insulin on Phospholipid Metabolism in Rat Adipose Tissue: Requirement for Protein Synthesis and a Carbohydrate Source, and Relationship to Activation of Pyruvate Dehydrogenase (1984) (18)
- Localization of the metabolic processes affected by calcium during corticotropin action. (1977) (18)
- BMI-related progression of atypical PKC-dependent aberrations in insulin signaling through IRS-1, Akt, FoxO1 and PGC-1α in livers of obese and type 2 diabetic humans. (2015) (18)
- The Mechanism of Action of Insulin on Phospholipid Metabolism in Rat Adipose Tissue: Requirement for Protein Synthesis and a Carbohydrate Source, and Relationship to Activation of Pyruvate Dehydrogenase (1984) (18)
- Coordinated regulation of hepatic FoxO1, PGC-1α and SREBP-1c facilitates insulin action and resistance. (2018) (17)
- Effects of phorbol esters on insulin‐induced activation of phosphatidylinositol 3‐kinase, glucose transport, and glycogen synthase in rat adipocytes (1996) (17)
- Fat breakdown: a function for CGI-58 (ABHD5) provides a new piece of the puzzle. (2006) (17)
- A Systematic Protein Turnover Map for Decoding Protein Degradation (2020) (17)
- Phosphatidylinositol hydrolysis and phosphatidylinositol 4',5-diphosphate hydrolysis are separable responses during secretagogue action in the rat pancreas. (1985) (17)
- Differential effects of pertussis toxin on insulin-stimulated phosphatidylcholine hydrolysis and glycerolipid synthesis de novo. Studies in BC3H-1 myocytes and rat adipocytes. (1991) (17)
- The CYTOLD and ERTOLD pathways for lipid droplet-protein targeting. (2021) (16)
- THE PHOSPHATIDATE‐POLYPHOSPHOINOSITIDE CYCLE: ACTIVATION BY PARATHYROID HORMONE AND DIBUTYRYL‐cAMP IN RABBIT KIDNEY CORTEX * (1981) (16)
- Global Analyses of Selective Insulin Resistance in Hepatocytes Caused by Palmitate Lipotoxicity * (2018) (16)
- Deletion of Protein Kinase C λ in POMC Neurons Predisposes to Diet-Induced Obesity (2017) (15)
- Atypical PKC, PKCλ/ι, activates β-secretase and increases Aβ1–40/42 and phospho-tau in mouse brain and isolated neuronal cells, and may link hyperinsulinemia and other aPKC activators to development of pathological and memory abnormalities in Alzheimer's disease (2018) (15)
- Direct evidence for protein kinase C involvement in insulin-stimulated hexose uptake. (1992) (15)
- Kinetic aspects of cycloheximide-induced reversal of adrenocorticotropin effects on steroidogenesis and adrenal phospholipids in vivo. (1980) (15)
- Atypical PKC: a target for treating insulin-resistant disorders of obesity, the metabolic syndrome and type 2 diabetes mellitus (2014) (15)
- Combined thiazolidinedione–metformin treatment synergistically improves insulin signalling to insulin receptor substrate-1-dependent phosphatidylinositol 3-kinase, atypical protein kinase C and protein kinase B/Akt in human diabetic muscle (2008) (15)
- Insulin activates myelin basic protein (p42 MAP) kinase by a protein kinase C‐independent pathway in rat adipocytes (1993) (15)
- Effects of angiotensin II and dibutyryl cyclic adenosine monophosphate on phosphatidylinositol metabolism, 45Ca2+ fluxes, and aldosterone synthesis in bovine adrenal glomerulosa cells. (1983) (15)
- FIT2 is a lipid phosphate phosphatase crucial for endoplasmic reticulum homeostasis (2018) (15)
- Mice lacking lipid droplet-associated hydrolase, a gene linked to human prostate cancer, have normal cholesterol ester metabolism[S] (2016) (14)
- Insulin-stimulated phosphatidylcholine hydrolysis, diacylglycerol/protein kinase C signalling, and hexose transport in pertussis toxin-treated BC3H-1 myocytes. (1994) (14)
- Seipin forms a flexible cage at lipid droplet formation sites (2021) (14)
- On the role of intra-adrenal unesterified cholesterol in the steroidogenic effect of corticotropin. (1978) (14)
- Stimulatory effects of calcium on protein synthesis in adrenal (and thyroidal) cell-free systems as related to trophic hormone action. (1971) (14)
- Persistence of the steroidogenic effect of adenosin-3',5'-monophosphate in vitro: evidence for a third factor during the steroidogenic effect of ACTH. (1969) (14)
- Differential effect of aging on protein kinase C activity in rat adipocytes and soleus muscle. (1993) (14)
- Early effects of ACTH on adrenal protein synthesis. (1966) (13)
- ACTH increases de novo synthesis of diacylglycerol and translocates protein kinase C in primary cultures of calf adrenal glomerulosa cells. (1990) (13)
- Modification of the apolipoprotein B gene in HepG2 cells by gene targeting. (1992) (13)
- Preferential activation of microsomal diacylglycerol/protein kinase C signaling during glucose treatment (De Novo phospholipid synthesis) of rat adipocytes. (1994) (13)
- Insulin administration in vivo increases 1,2-diacylglycerol in rat skeletal muscle. (1991) (13)
- Proteomic and phosphoproteomic analyses of yeast reveal the global cellular response to sphingolipid depletion (2016) (13)
- Further observations on the increases in inositide phospholipids after stimulation by ACTH, cAMP and insulin, and on discrepancies in phosphatidylinositol mass and 32PO4-labeling during inhibition of hormonal effects by cycloheximide. (1983) (13)
- Adrenocortical Lipid Depletion Gene (ald) in AKR Mice Is Associated with an Acyl-CoA:Cholesterol Acyltransferase (ACAT) Mutation* (1998) (13)
- Ca2+-dependent and Ca2+-independent mechanisms for phosphatidylinositol hydrolysis and 32P-labeling during cholinergic stimulation of the rat submaxillary gland in vitro. (1982) (12)
- Kinetic aspects of cycloheximide-induced reversal of adrenocorticotropin effects on steroidogenesis and phospholipid metabolism in rat adrenal sections in vitro. (1981) (12)
- Contrasting insulin dose-dependent defects in activation of atypical protein kinase C and protein kinase B/Akt in muscles of obese diabetic humans (2006) (12)
- Effects of ACTH and cyclic-AMP in vitro on incorporation of 3H-leucine and 14C-orotic acid into protein and RNA in the presence of an inhibitor of cholesterol side chain cleavage. (1969) (12)
- Progranulin in the hematopoietic compartment protects mice from atherosclerosis. (2018) (12)
- Insulin translocates PKC-ϵ and phorbol esters induce and persistently translocate PKC-β2 in BC3H-1 myocytes (1996) (12)
- Familial hypobetalipoproteinemia. (1993) (12)
- Adrenocortical lipid depletion gene (ald) in AKR mice is associated with an acyl-CoA:cholesterol acyltransferase (ACAT) mutation. (1997) (12)
- MGAT2 deficiency and vertical sleeve gastrectomy have independent metabolic effects in the mouse. (2014) (11)
- PKCλ haploinsufficiency prevents diabetes by a mechanism involving alterations in hepatic enzymes. (2014) (11)
- Studies of in vivo phosphorylated proteins in BC3H‐1 myocytes suggest that protein kinase C is involved in insulin action (1989) (11)
- Insulin signaling and insulin sensitizing in muscle and liver of obese monkeys: peroxisome proliferator-activated receptor gamma agonist improves defective activation of atypical protein kinase C. (2011) (11)
- Atypical protein kinase C in cardiometabolic abnormalities (2012) (10)
- Impairment of insulin-stimulated glucose transport and ERK activation by adipocyte-specific knockout of PKC-λ produces a phenotype characterized by diminished adiposity and enhanced insulin suppression of hepatic gluconeogenesis (2013) (10)
- Cbl PYXXM motifs activate the P85 subunit of phosphatidylinositol 3-kinase, Crk, atypical protein kinase C, and glucose transport during thiazolidinedione action in 3T3/L1 and human adipocytes. (2003) (10)
- Deficiency of the frontotemporal dementia gene GRN results in gangliosidosis (2022) (10)
- Identification of two pathways mediating protein targeting from ER to lipid droplets (2021) (10)
- Prostaglandin F 2 a stimulates phosphatidylinositol 4 , 5-bisphosphate hydrolysis and mobilizes intracellular Ca 2 " in bovine luteal cells ( " second messengers " / inositol phosphates / calcium / phospholipase C / corpus luteum ) (10)
- Okadaic Acid Activates Atypical Protein Kinase C (ζ/λ) in Rat and 3T3/L1 Adipocytes (1999) (10)
- Corticotropin-induced changes in a soluble desmolase preparation. (1978) (10)
- 2-Hydroxypropyl-beta-cyclodextrin enhances phorbol ester effects on glucose transport and/or protein kinase C-beta translocation to the plasma membrane in rat adipocytes and soleus muscles. (1993) (10)
- An update on the role of phospholipid metabolism in the action of steroidogenic agents. (1987) (10)
- ACAT inhibition and the progression of coronary atherosclerosis. (2006) (9)
- Insulin-like effects of sodium orthovanadate on diacylglycerol-protein kinase C signaling in BC3H-1 myocytes. (1994) (9)
- Insulin provokes apparent increases in rat adipocyte M-kinase. (1990) (9)
- Changes in Adrenal Polysomes Following ACTH Administration1 (1965) (9)
- QUANTITATIVE COMPARISON OF THE EFFECTS OF ACTH ADMINISTRATION ON THE ACTIVITIES OF SOLUBLE CELL FRACTION AND MICROSOMES FOR INCORPORATION OF AMINO ACID INTO PROTEIN. (1965) (8)
- Protein kinase C(19–31) pseudosubstrate inhibition of insulin action in rat adipocytes (1991) (8)
- The apolipoprotein C‐II variant apoC‐IILys19→Thr is not associated with dyslipidemia in an affected kindred (1994) (8)
- CHANGES IN (14C)GLYCINE-INCORPORATING ACTIVITIES OF RAT-ADRENAL MICROSOMES AND SOLUBLE CELL FRACTION DURING PROLONGED ADRENOCORTICOTROPIN ADMINISTRATION. (1964) (8)
- Effects of dibutyryl cyclic AMP and theophylline on rat pancreatic phospholipids in vitro. Ca2+-sensitive decrease in phosphatidylinositol and cycloheximide-sensitive increase in phosphatidic acid. (1981) (8)
- Hepatic acyl-CoA:diacylglcyerol acyltransferase (DGAT) overexpression, diacylglycerol, and insulin sensitivity (2011) (8)
- Atrial natriuretic hormone prohormone gene expression in cardiac and extra-cardiac tissues of diabetic Goto-Kakizaki rats (2003) (8)
- Hepatic acyl-CoA:diacylglcyerol acyltransferase (DGAT) overexpression, diacylglycerol, and insulin sensitivity (2011) (8)
- The Lipid Droplet Knowledge Portal: A resource for systematic analyses of lipid droplet biology. (2022) (8)
- Intracellular Phospholipid Signaling Systems (1988) (8)
- Inhibition of cholesterol side chain cleavage by cyanoketone. (1970) (8)
- Phorbol ester inhibition of insulin-stimulated deoxyribonucleic acid synthesis in BC3H-1 myocytes. (1987) (7)
- 156. Roux-en-Y Gastric Bypass Reduces Oxidative Stress and Down Regulates Pro-Inflammatory Genes in Livers of Obese Rats and in Kupffer Cells via an AMPK-Dependent Pathway (2009) (7)
- Further Evidence Implicating Diacylglycerol Generation and Protein Kinase C Activation in Agonist-Induced Increases in Glucose Uptake: Insulin-Like Effects of Phenylephrine in BC3H-1 Myocytes (1986) (7)
- Key Factors Governing Initial Stages of Lipid Droplet Formation (2021) (7)
- Non-esterified cholesterol-rich adrenal lipid fractions. Preparation, properties and preferential utilization for cholesterol side-chain cleavage by corticotropin-stimulated adrenal mitochondria. (1980) (7)
- Who Is at Greatest Risk for Receiving Poor-Quality Health Care? (2006) (7)
- Protein kinase C downregulation? (1992) (7)
- Limited Stage Small Cell Lung Cancer: Analysis of Clinical Prognostic Factors (1987) (7)
- Glucose Activates Protein Kinase C-ζ/λ through Proline-rich Tyrosine Kinase-2, Extracellular Signal-regulated Kinase, and Phospholipase D (2001) (7)
- Identification and characterization of truncated forms of apolipoprotein B in hypobetalipoproteinemia. (1996) (6)
- Angiotensin II increases diacylglycerol in calf adrenal glomerulosa cells by activating de novo phospholipid synthesis. (1989) (6)
- Seipin transmembrane segments critically function in triglyceride nucleation and lipid droplet budding from the membrane (2021) (6)
- Structure and catalytic mechanism of a human triacylglycerol-synthesis enzyme (2020) (6)
- The role of the phosphatidate-inositide cycle in the action of steroidogenic agents. (1983) (5)
- Isotropic 3D electron microscopy reference library of whole cells and tissues (2020) (5)
- URINARY PROSTAGLANDINS FOLLOWING FRUSEMIDE TREATMENT AND SALT DEPLETION IN NORMAL SUBJECTS AND SUBJECTS WITH DIABETIC HYPORENINAEMIC HYPOALDOSTERONISM (1980) (5)
- Calcium as an intracellular mediator of hormone action: intracellular phospholipid signaling systems. (1988) (5)
- A new way to look at fat (2011) (5)
- LH and GnRH acutely increase phosphatidylinositol levels in rat granulosa cells (1982) (5)
- Conditional targeting of phosphatidylserine decarboxylase to lipid droplets (2020) (4)
- Summary Development of the mammary gland requires DGAT 1 expression in stromal and epithelial tissues (2004) (4)
- Insulin translocates PKC-epsilon and phorbol esters induce and persistently translocate PKC-beta 2 in BC3H-1 myocytes. (1996) (4)
- Roles of hepatic atypical protein kinase C hyperactivity and hyperinsulinemia in insulin‐resistant forms of obesity and type 2 diabetes mellitus (2021) (4)
- Acute intermittent porphyria associated with inappropriate antidiuretic hormone secretion, hypokalemic alkalosis, and secondary hyperaldosteronism. (1979) (4)
- Apparent increases in phospholipid degradation and turnover during combined treatment with protein synthesis inhibitors and adrenocorticotropin. (1984) (4)
- The role of inositide phospholipids in the action of steroidogenic hormones. (1982) (4)
- The Lipid Droplet Knowledge Portal: A resource for systematic analyses of lipid droplet biology (2021) (3)
- External calcium is required for activation of phospholipase C by angiotensin II in adrenal glomerulosa cells (1990) (3)
- Resolution of propylthiouracil-induced hepatic failure after treatment of thyrotoxicosis. (1997) (3)
- REPLETION OF ATYPICAL PROTEIN KINASE C FOLLOWING RNAi-MEDIATED DEPLETION RESTORES INSULIN-STIMULATED GLUCOSE TRANSPORT. (2006) (3)
- Abstract 17736: Cardiomyocyte Specific Loss of Diacylglycerol Acyl Transferase 1 (Dgat1) Reproduces the Abnormalities in Lipids Found in Severe Heart Failure (2014) (3)
- The effects of imidazole on adrenal metabolism in vitro. (1970) (3)
- Hepatic Atypical Protein Kinase C: An Inherited Survival-Longevity Gene that Now Fuels Insulin-Resistant Syndromes of Obesity, the Metabolic Syndrome and Type 2 Diabetes Mellitus (2014) (3)
- The structure, catalytic mechanism, and inhibitor identification of phosphatidylinositol remodeling MBOAT7 (2022) (3)
- Effects of insulin and phorbol esters on MARCKS ( myristoylated alanine-rich C-kinase substrate ) phosphorylation ( and other parameters of protein kinase C activation ) in rat adipocytes , rat soleus muscle and BC 3 H-1 myocytes (2005) (3)
- Contraction stimulates muscle glucose uptake independent of atypical PKC (2015) (3)
- Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis (fatty acidycloningyexpressed sequence tagyglycerolipid) (1998) (2)
- The De Novo Phospholipid Synthesis Effect: Occurrence, Characteristics, Underlying Mechanisms and Functional Significance in Hormone Action and Secretion (1985) (2)
- Glycerolipid Synthesis and Lipid Droplet Formation in the Endoplasmic Reticulum. (2022) (2)
- The Troyer syndrome protein spartin mediates selective autophagy of lipid droplets (2021) (2)
- Lipodystrophy can be uncoupled from detrimental metabolic consequences (2)
- Atypical PKC controls β-secretase expression and thereby regulates production of Alzheimer plaque precursor Aβ in brain and insulin receptor degradation in liver. (2020) (2)
- EFFECT OF ADRENOCORTICOTROPHIN ON ADRENAL PROTEIN SYNTHESIS. (1963) (2)
- Atypical PKC: therapeutic target for Alzheimer’s? (2018) (2)
- The Advantages of FTD Drug Development ( Part 2 of FTD : The Next Therapeutic Frontier ) (2013) (1)
- The Role of Phospholipid Metabolism in Insulin Action (1987) (1)
- Increased longevity in mice lacking DGAT1 (2006) (1)
- Mechanisms for increases in the intracellular mediator diacylglycerol during insulin action (1987) (1)
- Tissue-specifi c knockouts of ACAT2 reveal that intestinal depletion is suffi cient to prevent diet-induced cholesterol accumulation in the liver and blood (2020) (1)
- The critical role of atypical protein kinase C in activating hepatic SREBP-1 c and NF k B in obesity Mini (2009) (1)
- Insulin increases mRNA levels of protein kinase Cx anda in rat adipocytes and protein kinase Cx ,-p andO in rat skeletal muscle (2005) (1)
- Erratum: Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKCλ/ζ (Cell Metabolism (2006) 3 (343-353)) (2016) (1)
- Insulin-Induced Activation of PKC-ζ Is Defective in Skeletal Muscles of Type 2 Diabetic Humans. Amelioration by Rosiglitazone (2002) (1)
- Frontotemporal Degeneration , the Next Therapeutic Frontier : Molecules and Animal Models for FTD drug development ( Part 1 of 2 articles ) (2013) (1)
- muscles of old vs. adult rats phosphorylation in the soleus, but not epitrochlearis, Insulin resistance for glucose uptake and Akt2 (2015) (1)
- The phase of fat: Mechanisms and physiology of lipid storage (2022) (1)
- Atypical Protein Kinase C Hyperactivity in Insulin-Resistant and Insulin-Sensitive Forms of Alzheimer’s Disease: A Potential Therapeutic Target (2020) (1)
- PKC AS A DOWNSTREAM EFFECTOR OF PI3 KINASE IN RAT ADIPOCYTES (2002) (1)
- 569 Downregulation of Adiponectin /Adipor2 Is Associated with Hepatic Inflammation and Steatosis in Obese Mice (2008) (1)
- Radiation in the Wild Multiple Fitness Peaks on the Adaptive Landscape Drive Adaptive (2013) (1)
- The role of the phosphatidate-phosphoinositide cycle in the action of steroidogenic hormones. (1984) (1)
- Un-phased: Lipid Droplets Modulate the Bioavailability of Antibiotics. (2019) (1)
- Méthodes de traitement d’une infection par le virus de l’hépatite c (2009) (0)
- Author response: Compensation for PKMζ in long-term potentiation and spatial long-term memory in mutant mice (2016) (0)
- Publisher Correction: An open-access volume electron microscopy atlas of whole cells and tissues (2021) (0)
- A Novel Murine Knock‐in Model for Progranulin‐deficient Frontotemporal Dementia with Nonsense‐mediated mRNA Decay (2018) (0)
- Effects of ACTH on adrenal RNA synthesis. (1967) (0)
- insulin-dependent GLUT4 translocation Muscle cells engage Rab8A and myosin Vb in (2010) (0)
- Duncan's Diseases of Metabolism, (1975) (0)
- Structure and function of lipid droplet assembly complexes (2023) (0)
- Chronic insulin treatment sensitizes adipocytes and muscles of GK diabetic rats by enhancing insulin-induced activation of PKC-ζ (2000) (0)
- Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency (2020) (0)
- Thiazolidinediones enhances basal and/or insulin-stimulated glucose transport in 3T3/L1 adipocytes and L6 myotubes by activating atypical PKCs ζ and λ (2000) (0)
- P-59: Insulin-sensitive phospholipid signalling systems and their relation to glucose transport (2009) (0)
- Gonadotropin-releasing hormone ( GnRH ) stimulates phosphatidylinositol metabolism in rat granulosa cells : Mechanism of action of GnRH * ( phospholipids / steroidogenesis / cyclic nucleotides ) (0)
- Murine Skin Essential for Retinoid Homeostasis in Retinol Esterification by DGAT 1 Is Regulation , and Signaling : Lipids and Lipoproteins : Metabolism (2014) (0)
- Porestoichiometryof a voltage-gatedchloridechannel (0)
- Genome‐wide screens in yeast reveal that diverse cellular pathways influence the toxicity of various neurodegenerative disease‐associated misfolded proteins (2010) (0)
- The Phase of Fat: Mechanisms and Physiology of Lipid Synthesis and Storage (2016) (0)
- Verfahren zur behandlung von hepatitis-c-virusinfektionen (2009) (0)
- Identification and characterization of a novel DGAT1 missense mutation associated with congenital diarrhea patient-oriented and epidemiological research (2020) (0)
- New From Annual Reviews : Annual Review of Statistics and Its Application (2014) (0)
- Alterations in Atypical Protein Kinase C Activation in Insulin Resistance Syndromes (2008) (0)
- Nouvelle acyl coa cholesterol aclytransferase (acat-2) (1999) (0)
- The role of diacylglycerol/protein kinase C signaling in insulin-stimulated glucose transport. (1991) (0)
- High-Confidence Yeast Lipid Droplet Proteome 1 High-confidence proteome analysis of yeast lipid droplets identifies additional droplet proteins and reveals connections to dolichol synthesis and sterol acetylation (2014) (0)
- Mechanism of Protein Targeting to Lipid Droplets (2018) (0)
- Contents of volumes 263, 264, 266–289 (1998) (0)
- Erratum to “A novel PKC-ι inhibitor abrogates cell proliferation and induces apoptosis in neuroblastoma” [Int. J. Biochem. Cell Biol. 43 (5) (2011) 784–794] (2011) (0)
- Pharmaceutics & Novel Drug Delivery Systems (2012) (0)
- Fitm2 is required for ER homeostasis and normal function of murine liver (2022) (0)
- Mechanisms and Physiology of Fat Synthesis and Storage (2016) (0)
- transport in insulin-sensitive and insulin-resistant states Function and dysfunction of aPKC isoforms for glucose (2016) (0)
- Diacylglycerol acyltransferase 1 (DGAT1) Functions as a Cellular “Hub” to Target Hepatitis C Virus Proteins NS5A and Core to Lipid Droplets (2012) (0)
- Hepatic a Typical PKC: A Novel Target for Newlydevelpoed Inhibitors that Reverse Obesity and Metabolic Syndrome and Diabetic Characteristics and Features in Human Hepatocytes and a Murine Obesity/Diabetes Model (2013) (0)
- Pertussis toxin-sensitive and -insensitive mechanisms for diacylglycerol-protein kinase C signalling during insulin action in BC3H-1 myocytes. (1990) (0)
- Control of β-Site Amyloid Precursor Protein-Cleaving Enzyme-1 Expression by Protein Kinase C-λ/ι and Nuclear Factor κ-B. (2021) (0)
- Intracellular Sterol Esterification: Two Acyl CoA:Cholesterol Acyltransferases in Mammals (1998) (0)
- Effect of Insulin and phorbol esters on MARKS phosphorylation in rat adipocytes, rat soleus muscle and BC3H-1 myocytes (2017) (0)
- Lipid droplet assembly factor-1 and seipin form a lipid droplet assembly complex (2020) (0)
- Linkage of atypical protein kinase C to Alzheimer disease (2020) (0)
- Insulin, concanavalin A, EGF, IFG-I and vanadate activate de novo phosphatidic acid and diacylglycerol synthesis, C-kinase, and glucose transport in BC3H-1 myocytes (1987) (0)
- The role of atypical PKCs in insulin-resistant states (2004) (0)
- An 8-week, open-label, dose-finding study of for the treatment of progranulin insufficiency from GRN gene mutations. (2017) (0)
- Procédés de traitement des maladies du foie (2009) (0)
- The power of two: lessons from a scientific partnership. (2021) (0)
- Title Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation Permalink (2016) (0)
- A NOVEL MURINE KNOCK-IN MODEL FOR PROGRANULIN-DEFICIENT FRONTOTEMPORAL DEMENTIA WITH NONSENSE-MEDIATED MRNA DECAY (2018) (0)
- Diacylglycerol acyltransferase-o (1998) (0)
- The Phase of Fat: Mechanisms and Regulation of Lipid Storage (2021) (0)
- Annotated Table of Contents (2017) (0)
- Mice lacking triglyceride synthesis enzymes in adipose tissue are resistant to diet-induced obesity (2023) (0)
- Progranulin deficiency results in reduced bis(monoacylglycero)phosphate (BMP) levels and gangliosidosis (2021) (0)
- Global Analyses of Selective Insulin Resistance in Hepatocytes due to Palmitate Lipotoxicity (2018) (0)
- temperatures in mice lacking DGAT1 Analysis of energy expenditure at different ambient (2013) (0)
- Genetic and Proteomic Dissection of TDP43 Toxicity in S. cerevisiae (2012) (0)
- Neuronal effects of progranulin deficiency contribute to frontotemporal dementia independent of neuroinflammation (2012) (0)
- Defective Insulin Activation of Protein Kinase C-ζ/λ in Skeletal Muscle of Obese Insulin-Resistant Rhesus Monkeys (2002) (0)
- Traitement d'une anomalie de l'enzyme protéine kinase c atypique (2014) (0)
- DEVELOPMENT OF NEWMODELS AND ANALYSIS METHODS: NOVEL MODEL SYSTEMS TO STUDY DEMENTIA O1-01-01 CHARACTERIZING PROTEIN AGGREGATES FROM THE HUMAN BRAIN (2018) (0)
- Publisher Correction: An open-access volume electron microscopy atlas of whole cells and tissues (2021) (0)
- 2FS05-2 Atypical protein kinase C and insulin resistance (2003) (0)
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