Robert W. Doms
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Microbiology
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Immunology
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Biology
Robert W. Doms's Degrees
- PhD Microbiology and Immunology University of Pennsylvania
- Bachelors Biology University of California, San Diego
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(Suggest an Edit or Addition)Robert W. Doms's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene (1996) (2991)
- A Dual-Tropic Primary HIV-1 Isolate That Uses Fusin and the β-Chemokine Receptors CKR-5, CKR-3, and CKR-2b as Fusion Cofactors (1996) (1991)
- A new classification for HIV-1 (1998) (899)
- HIV vaccine design and the neutralizing antibody problem (2004) (835)
- CD4-Independent Infection by HIV-2 Is Mediated by Fusin/CXCR4 (1996) (712)
- Quantification of CD4, CCR5, and CXCR4 levels on lymphocyte subsets, dendritic cells, and differentially conditioned monocyte-derived macrophages. (1999) (601)
- Diversity of receptors binding HIV on dendritic cell subsets (2002) (561)
- Brefeldin A redistributes resident and itinerant Golgi proteins to the endoplasmic reticulum (1989) (540)
- HIV: cell binding and entry. (2012) (527)
- Genetic acceleration of AIDS progression by a promoter variant of CCR5. (1998) (483)
- Folding and assembly of viral membrane proteins. (1993) (473)
- Constitutive and induced expression of DC‐SIGN on dendritic cell and macrophage subpopulations in situ and in vitro (2002) (459)
- Alzheimer's Aβ(1–42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells (1997) (451)
- Sensitivity of HIV-1 to entry inhibitors correlates with envelope/coreceptor affinity, receptor density, and fusion kinetics (2002) (439)
- Hepatitis C Virus Glycoproteins Interact with DC-SIGN and DC-SIGNR (2003) (426)
- Phenotypic properties of transmitted founder HIV-1 (2013) (389)
- Human immunodeficiency virus type 2. (2002) (386)
- A seven-transmembrane domain receptor involved in fusion and entry of T-cell-tropic human immunodeficiency virus type 1 strains (1996) (384)
- Oligomeric structure of the human immunodeficiency virus type 1 envelope glycoprotein. (1990) (378)
- Maturation and Endosomal Targeting of β-Site Amyloid Precursor Protein-cleaving Enzyme (2000) (370)
- Epitope Mapping of CCR5 Reveals Multiple Conformational States and Distinct but Overlapping Structures Involved in Chemokine and Coreceptor Function* (1999) (370)
- Assembly of influenza hemagglutinin trimers and its role in intracellular transport (1986) (361)
- DC-SIGN and DC-SIGNR bind ebola glycoproteins and enhance infection of macrophages and endothelial cells. (2003) (359)
- Utilization of chemokine receptors, orphan receptors, and herpesvirus-encoded receptors by diverse human and simian immunodeficiency viruses (1997) (357)
- Regulation of protein export from the endoplasmic reticulum. (1988) (357)
- Folding, interaction with GRP78-BiP, assembly, and transport of the human immunodeficiency virus type 1 envelope protein (1991) (356)
- A Small-molecule Inhibitor Directed against the Chemokine Receptor CXCR4 Prevents its Use as an HIV-1 Coreceptor (1997) (329)
- Membrane fusion activity of the influenza virus hemagglutinin. The low pH-induced conformational change. (1985) (324)
- Regions in β-Chemokine Receptors CCR5 and CCR2b That Determine HIV-1 Cofactor Specificity (1996) (324)
- Protein Kinase C-dependent α-Secretase Competes with β-Secretase for Cleavage of Amyloid-β Precursor Protein in the Trans-Golgi Network* (2000) (321)
- DC-SIGNR, a DC-SIGN homologue expressed in endothelial cells, binds to human and simian immunodeficiency viruses and activates infection in trans (2001) (318)
- Studies on the mechanism of membrane fusion: site-specific mutagenesis of the hemagglutinin of influenza virus (1986) (314)
- West Nile Virus Discriminates between DC-SIGN and DC-SIGNR for Cellular Attachment and Infection (2006) (306)
- Assembly of vaccinia virus: role of the intermediate compartment between the endoplasmic reticulum and the Golgi stacks (1993) (302)
- Detection of a Novel Intraneuronal Pool of Insoluble Amyloid β Protein that Accumulates with Time in Culture (1998) (297)
- Stable exposure of the coreceptor-binding site in a CD4-independent HIV-1 envelope protein. (1999) (296)
- The entry of entry inhibitors: A fusion of science and medicine (2003) (294)
- The plasma membrane as a combat zone in the HIV battlefield. (2000) (286)
- Unwelcomed guests with master keys: how HIV uses chemokine receptors for cellular entry. (1997) (286)
- Microglia Express CCR5, CXCR4, and CCR3, but of These, CCR5 Is the Principal Coreceptor for Human Immunodeficiency Virus Type 1 Dementia Isolates (1999) (283)
- Expression of DC-SIGN by Dendritic Cells of Intestinal and Genital Mucosae in Humans and Rhesus Macaques (2002) (282)
- CCR5 binds multiple CC-chemokines: MCP-3 acts as a natural antagonist. (1999) (278)
- CD4-independent, CCR5-dependent infection of brain capillary endothelial cells by a neurovirulent simian immunodeficiency virus strain. (1997) (277)
- Role for adenosine triphosphate in regulating the assembly and transport of vesicular stomatitis virus G protein trimers (1987) (266)
- ChemR23, a putative chemoattractant receptor, is expressed in monocyte‐derived dendritic cells and macrophages and is a coreceptor for SIV and some primary HIV‐1 strains (1998) (259)
- Differential N-Linked Glycosylation of Human Immunodeficiency Virus and Ebola Virus Envelope Glycoproteins Modulates Interactions with DC-SIGN and DC-SIGNR (2003) (255)
- Two distinct CCR5 domains can mediate coreceptor usage by human immunodeficiency virus type 1 (1997) (244)
- Native oligomeric human immunodeficiency virus type 1 envelope glycoprotein elicits diverse monoclonal antibody reactivities (1994) (238)
- Castanospermine, a Potent Inhibitor of Dengue Virus Infection In Vitro and In Vivo (2005) (237)
- Identification of CXCR4 Domains That Support Coreceptor and Chemokine Receptor Functions (1999) (236)
- Differential utilization of CCR5 by macrophage and T cell tropic simian immunodeficiency virus strains. (1997) (236)
- DC-SIGN Interactions with Human Immunodeficiency Virus Type 1 and 2 and Simian Immunodeficiency Virus (2001) (227)
- Protein-mediated membrane fusion. (1989) (226)
- Evolution of HIV-1 coreceptor usage through interactions with distinct CCR5 and CXCR4 domains. (1997) (223)
- Entry inhibitors in the treatment of HIV-1 infection. (2010) (221)
- Maturation and endosomal targeting of beta-site amyloid precursor protein-cleaving enzyme. The Alzheimer's disease beta-secretase. (2000) (221)
- An Orphan Seven-Transmembrane Domain Receptor Expressed Widely in the Brain Functions as a Coreceptor for Human Immunodeficiency Virus Type 1 and Simian Immunodeficiency Virus (1998) (218)
- Expression and analysis of presenilin 1 in a human neuronal system: localization in cell bodies and dendrites. (1996) (216)
- N-Linked Glycosylation of West Nile Virus Envelope Proteins Influences Particle Assembly and Infectivity (2005) (208)
- cis Expression of DC-SIGN Allows for More Efficient Entry of Human and Simian Immunodeficiency Viruses via CD4 and a Coreceptor (2001) (207)
- Role of CCR5 in infection of primary macrophages and lymphocytes by macrophage-tropic strains of human immunodeficiency virus: resistance to patient-derived and prototype isolates resulting from the delta ccr5 mutation (1997) (207)
- Expression of multiple functional chemokine receptors and monocyte chemoattractant protein-1 in human neurons (2000) (207)
- Dissecting the Neutralizing Antibody Specificities of Broadly Neutralizing Sera from Human Immunodeficiency Virus Type 1-Infected Donors (2007) (204)
- Beyond receptor expression: the influence of receptor conformation, density, and affinity in HIV-1 infection. (2000) (202)
- Molecular mechanisms of HIV entry. (2012) (199)
- Differential effects of mutations in three domains on folding, quaternary structure, and intracellular transport of vesicular stomatitis virus G protein (1988) (196)
- A rapid and quantitative assay for measuring antibody-mediated neutralization of West Nile virus infection. (2006) (193)
- Intracellular APP Processing and Aβ Production in Alzheimer Disease (1999) (183)
- The CC Chemokine I-309 Inhibits CCR8-dependent Infection by Diverse HIV-1 Strains* (1998) (181)
- Antigenically Distinct Conformations of CXCR4 (2001) (180)
- Fusion of intra- and extracellular forms of vaccinia virus with the cell membrane (1990) (177)
- Truncation of the Cytoplasmic Domain Induces Exposure of Conserved Regions in the Ectodomain of Human Immunodeficiency Virus Type 1 Envelope Protein (2002) (176)
- Envelope residue 375 substitutions in simian–human immunodeficiency viruses enhance CD4 binding and replication in rhesus macaques (2016) (174)
- Influence of the CCR2-V64I Polymorphism on Human Immunodeficiency Virus Type 1 Coreceptor Activity and on Chemokine Receptor Function of CCR2b, CCR3, CCR5, and CXCR4 (1998) (174)
- HIV-1 Membrane Fusion (2000) (171)
- Enfuvirtide Resistance Mutations: Impact on Human Immunodeficiency Virus Envelope Function, Entry Inhibitor Sensitivity, and Virus Neutralization (2005) (169)
- The Core Domain of Chemokines Binds CCR5 Extracellular Domains while Their Amino Terminus Interacts with the Transmembrane Helix Bundle* (2003) (168)
- Identification of Determinants on a Dualtropic Human Immunodeficiency Virus Type 1 Envelope Glycoprotein That Confer Usage of CXCR4 (1998) (168)
- β-Secretase Processing in the Trans-Golgi Network Preferentially Generates Truncated Amyloid Species That Accumulate in Alzheimer's Disease Brain* (2002) (166)
- HIV Transmission (2004) (165)
- Heavy chain binding protein recognizes incompletely disulfide-bonded forms of vesicular stomatitis virus G protein. (1990) (164)
- HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation. (2000) (161)
- Multiple Charged and Aromatic Residues in CCR5 Amino-terminal Domain Are Involved in High Affinity Binding of Both Chemokines and HIV-1 Env Protein* (1999) (160)
- Use of a Small Molecule CCR5 Inhibitor in Macaques to Treat Simian Immunodeficiency Virus Infection or Prevent Simian–Human Immunodeficiency Virus Infection (2003) (157)
- Characterization of Chemokine Receptor Utilization of Viruses in the Latent Reservoir for Human Immunodeficiency Virus Type 1 (2000) (156)
- Use of GPR1, GPR15, and STRL33 as coreceptors by diverse human immunodeficiency virus type 1 and simian immunodeficiency virus envelope proteins. (1998) (156)
- Transmitted/Founder and Chronic Subtype C HIV-1 Use CD4 and CCR5 Receptors with Equal Efficiency and Are Not Inhibited by Blocking the Integrin α4β7 (2012) (154)
- Placental expression of DC‐SIGN may mediate intrauterine vertical transmission of HIV (2001) (152)
- Relationships between CD4 Independence, Neutralization Sensitivity, and Exposure of a CD4-Induced Epitope in a Human Immunodeficiency Virus Type 1 Envelope Protein (2001) (148)
- Retroviral mRNA nuclear export elements regulate protein function and virion assembly (2004) (146)
- Phenotypic and Immunologic Comparison of Clade B Transmitted/Founder and Chronic HIV-1 Envelope Glycoproteins (2011) (146)
- Conformational changes and fusion activity of influenza virus hemagglutinin of the H2 and H3 subtypes: effects of acid pretreatment (1990) (144)
- Engineering HIV-Resistant Human CD4+ T Cells with CXCR4-Specific Zinc-Finger Nucleases (2011) (144)
- Palmitoylation of CCR5 Is Critical for Receptor Trafficking and Efficient Activation of Intracellular Signaling Pathways* (2001) (144)
- Simultaneous zinc-finger nuclease editing of the HIV coreceptors ccr5 and cxcr4 protects CD4+ T cells from HIV-1 infection. (2014) (139)
- Determinants of CD4 Independence for a Human Immunodeficiency Virus Type 1 Variant Map outside Regions Required for Coreceptor Specificity (1999) (138)
- Chemokine Receptor Utilization by Human Immunodeficiency Virus Type 1 Isolates That Replicate in Microglia (1998) (136)
- BACE overexpression alters the subcellular processing of APP and inhibits Aβ deposition in vivo (2005) (135)
- CD4 Independence of Simian Immunodeficiency Virus Envs Is Associated with Macrophage Tropism, Neutralization Sensitivity, and Attenuated Pathogenicity (2002) (135)
- A Sound Rationale Needed for Phase III HIV-1 Vaccine Trials (2004) (133)
- Antigenic implications of human immunodeficiency virus type 1 envelope quaternary structure: oligomer-specific and -sensitive monoclonal antibodies. (1994) (132)
- Characterization of neutralizing antibodies to West Nile virus. (2005) (130)
- Quaternary structure of influenza virus hemagglutinin after acid treatment (1986) (129)
- Novel β-Secretase Cleavage of β-Amyloid Precursor Protein in the Endoplasmic Reticulum/Intermediate Compartment of NT2N Cells (1997) (128)
- Impact of Mutations in the Coreceptor Binding Site on Human Immunodeficiency Virus Type 1 Fusion, Infection, and Entry Inhibitor Sensitivity (2004) (127)
- Glu11 site cleavage and N-terminally truncated A beta production upon BACE overexpression. (2002) (126)
- Extracellular Cysteines of CCR5 Are Required for Chemokine Binding, but Dispensable for HIV-1 Coreceptor Activity* (1999) (125)
- Cellular Localization and Antigenic Characterization of Crimean-Congo Hemorrhagic Fever Virus Glycoproteins (2005) (124)
- HIV-1 entry and its inhibition. (2003) (124)
- Assembly of vaccinia virus: effects of rifampin on the intracellular distribution of viral protein p65 (1994) (123)
- A Maraviroc-Resistant HIV-1 with Narrow Cross-Resistance to Other CCR5 Antagonists Depends on both N-Terminal and Extracellular Loop Domains of Drug-Bound CCR5 (2010) (119)
- Use of a gp120 Binding Assay To Dissect the Requirements and Kinetics of Human Immunodeficiency Virus Fusion Events (1999) (116)
- Quantitative Expression and Virus Transmission Analysis of DC-SIGN on Monocyte-Derived Dendritic Cells (2002) (115)
- Multiple nonfunctional alleles of CCR5 are frequent in various human populations. (2000) (115)
- Safe use of the CXCR4 inhibitor ALX40-4C in humans. (2001) (114)
- HIV type I envelope determinants for use of the CCR2b, CCR3, STRL33, and APJ coreceptors. (1998) (112)
- HIV-1 envelope determinants for cell tropism and chemokine receptor use. (1999) (112)
- Comparing Antigenicity and Immunogenicity of Engineered gp120 (2005) (111)
- DC-SIGN and DC-SIGNR: helping hands for HIV. (2001) (111)
- HIV-1 coreceptors and their inhibitors. (2006) (109)
- A biosensor assay for studying ligand-membrane receptor interactions: binding of antibodies and HIV-1 Env to chemokine receptors. (2000) (109)
- Epitope map of human immunodeficiency virus type 1 gp41 derived from 47 monoclonal antibodies produced by immunization with oligomeric envelope protein (1997) (109)
- The Location of Asparagine-linked Glycans on West Nile Virions Controls Their Interactions with CD209 (Dendritic Cell-specific ICAM-3 Grabbing Nonintegrin)* (2006) (102)
- Presenilins are not required for Aβ42 production in the early secretory pathway (2002) (102)
- An infectious West Nile virus that expresses a GFP reporter gene. (2005) (99)
- Posttranslational oligomerization and cooperative acid activation of mixed influenza hemagglutinin trimers (1988) (98)
- Intracellular transport of soluble and membrane‐bound glycoproteins: folding, assembly and secretion of anchor‐free influenza hemagglutinin. (1990) (97)
- Modulation of Env Content in Virions of Simian Immunodeficiency Virus: Correlation with Cell Surface Expression and Virion Infectivity (2004) (97)
- Variant influenza virus hemagglutinin that induces fusion at elevated pH (1986) (97)
- Functional Dissection of CCR5 Coreceptor Function through the Use of CD4-Independent Simian Immunodeficiency Virus Strains (1999) (97)
- Quantitative phosphoproteomics reveals extensive cellular reprogramming during HIV-1 entry. (2013) (96)
- Expression and coreceptor activity of STRL33/Bonzo on primary peripheral blood lymphocytes. (2000) (96)
- The Chemokine Stromal Cell-Derived Factor-1 Promotes the Survival of Embryonic Retinal Ganglion Cells (2003) (94)
- A Haploid Genetic Screen Identifies Heparan Sulfate Proteoglycans Supporting Rift Valley Fever Virus Infection (2015) (94)
- Cell-cell fusion assay to study role of chemokine receptors in human immunodeficiency virus type 1 entry. (1997) (93)
- The role of DC-SIGN and DC-SIGNR in HIV and SIV attachment, infection, and transmission. (2001) (91)
- V3 Loop Truncations in HIV-1 Envelope Impart Resistance to Coreceptor Inhibitors and Enhanced Sensitivity to Neutralizing Antibodies (2007) (90)
- Coreceptor/chemokine receptor expression on human hematopoietic cells: biological implications for human immunodeficiency virus-type 1 infection. (1999) (88)
- A Replication-Competent, Neutralization-Sensitive Variant of Simian Immunodeficiency Virus Lacking 100 Amino Acids of Envelope (2002) (88)
- Membrane Topology of γ-Secretase Component PEN-2* (2003) (88)
- Transmitted/Founder and Chronic HIV-1 Envelope Proteins Are Distinguished by Differential Utilization of CCR5 (2012) (85)
- Functional and Antigenic Characterization of Human, Rhesus Macaque, Pigtailed Macaque, and Murine DC-SIGN (2001) (82)
- Membrane Topology and Nicastrin-enhanced Endoproteolysis of APH-1, a Component of the γ-Secretase Complex* (2004) (80)
- Humoral response to oligomeric human immunodeficiency virus type 1 envelope protein (1996) (79)
- Identification of a Novel C-Terminal Cleavage of Crimean-Congo Hemorrhagic Fever Virus PreGN That Leads to Generation of an NSM Protein (2007) (79)
- Chemokine receptors as fusion cofactors for human immunodeficiency virus type 1 (HIV-1) (1997) (79)
- CCR5 genotypes in sexually active couples discordant for human immunodeficiency virus type 1 infection status. (1997) (78)
- Secretion and Intracellular Generation of Truncated Aβ in β-Site Amyloid-β Precursor Protein-cleaving Enzyme Expressing Human Neurons* (2003) (77)
- Derivation and biological characterization of a molecular clone of SHIV(KU-2) that causes AIDS, neurological disease, and renal disease in rhesus macaques. (1999) (76)
- The Major Cellular Sterol Regulatory Pathway Is Required for Andes Virus Infection (2014) (75)
- Clinical Resistance to Enfuvirtide Does Not Affect Susceptibility ofHuman Immunodeficiency Virus Type 1 to Other Classes of Entry Inhibitors (2007) (75)
- The Transmembrane Domain Region of Nicastrin Mediates Direct Interactions with APH-1 and the γ-Secretase Complex* (2003) (75)
- Effect of nonpolar substitutions of the conserved Phe11 in the fusion peptide of HIV-1 gp41 on its function, structure, and organization in membranes. (1999) (73)
- DC-SIGN Interactions with Human Immunodeficiency Virus: Virus Binding and Transfer Are Dissociable Functions (2001) (72)
- Beta-secretase processing in the trans-Golgi network preferentially generates truncated amyloid species that accumulate in Alzheimer's disease brain. (2002) (72)
- A distinct ER/IC gamma-secretase competes with the proteasome for cleavage of APP. (2000) (71)
- Chemokines and coreceptors in HIV/SIV-host interactions. (1998) (67)
- Characterization of human immunodeficiency virus type 1 gp120 binding to liposomes containing galactosylceramide (1994) (67)
- Characterization and Epitope Mapping of Neutralizing Monoclonal Antibodies Produced by Immunization with Oligomeric Simian Immunodeficiency Virus Envelope Protein (2000) (67)
- Chemokine receptors and HIV entry. (2001) (67)
- Prospects of HIV‐1 entry inhibitors as novel therapeutics (2004) (66)
- HIV-1 Resistance to CCR5 Antagonists Associated with Highly Efficient Use of CCR5 and Altered Tropism on Primary CD4+ T Cells (2010) (66)
- HIV-1 Membrane Fusion: Targets of Opportunity (2000) (65)
- Structure-function studies of the HIV-1 coreceptors. (1998) (65)
- HIV type 1 from a patient with baseline resistance to CCR5 antagonists uses drug-bound receptor for entry. (2010) (64)
- An Engineered Saccharomyces cerevisiae Strain Binds the Broadly Neutralizing Human Immunodeficiency Virus Type 1 Antibody 2G12 and Elicits Mannose-Specific gp120-Binding Antibodies (2008) (63)
- CD4-independent utilization of the CXCR4 chemokine receptor by HIV-1 and HIV-2. (1998) (62)
- Intracellular APP processing and A beta production in Alzheimer disease. (1999) (60)
- HR-2 Mutations in Human Immunodeficiency Virus Type 1 gp41 Restore Fusion Kinetics Delayed by HR-1 Mutations That Cause Clinical Resistance to Enfuvirtide (2009) (58)
- Novel Approaches to Inhibit HIV Entry (2012) (58)
- Primary Infection by a Human Immunodeficiency Virus with Atypical Coreceptor Tropism (2011) (57)
- Human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus env proteins possess a functionally conserved assembly domain (1990) (56)
- Qualitative T-Helper Responses to Multiple Viral Antigens Correlate with Vaccine-Induced Immunity to Simian/Human Immunodeficiency Virus Infection (2004) (56)
- Development and characterization of a Rift Valley fever virus cell–cell fusion assay using alphavirus replicon vectors (2006) (56)
- The role of DC-SIGN and DC-SIGNR in HIV and Ebola virus infection: can potential therapeutics block virus transmission and dissemination? (2002) (56)
- Differential Effects of the Swedish Mutant Amyloid Precursor Protein on β-Amyloid Accumulation and Secretion in Neurons and Nonneuronal Cells* (1997) (55)
- Presence of broadly reactive and group-specific neutralizing epitopes on newly described isolates of Crimean-Congo hemorrhagic fever virus. (2005) (55)
- Chemokine and orphan receptors in HIV-2 and SIV tropism and pathogenesis. (1999) (55)
- Rift Valley Fever Virus Infection of Human Cells and Insect Hosts Is Promoted by Protein Kinase C Epsilon (2010) (55)
- Identification of gp120 Binding Sites on CXCR4 by Using CD4-Independent Human Immunodeficiency Virus Type 2 Env Proteins (2003) (52)
- Enhanced Exposure of the CD4-Binding Site to Neutralizing Antibodies by Structural Design of a Membrane-Anchored Human Immunodeficiency Virus Type 1 gp120 Domain (2009) (48)
- An Intricate Web: Chemokine Receptors, HIV‐1 and Hematopoiesis (1998) (47)
- Focused dampening of antibody response to the immunodominant variable loops by engineered soluble gp140. (2008) (47)
- Quantitative Phosphoproteomics of CXCL12 (SDF-1) Signaling (2011) (45)
- Expression and coreceptor function of APJ for primate immunodeficiency viruses. (2000) (45)
- HIV and SIV gp120 binding does not predict coreceptor function. (1999) (44)
- The influenza hemagglutinin precursor as an acid‐sensitive probe of the biosynthetic pathway. (1987) (44)
- Leukotriene Binding, Signaling, and Analysis of HIV Coreceptor Function in Mouse and Human Leukotriene B4Receptor-transfected Cells* (1999) (43)
- Inefficient entry of vicriviroc-resistant HIV-1 via the inhibitor-CCR5 complex at low cell surface CCR5 densities. (2009) (42)
- Secretion and intracellular generation of truncated Abeta in beta-site amyloid-beta precursor protein-cleaving enzyme expressing human neurons. (2003) (42)
- Presenilin modulates Pen-2 levels posttranslationally by protecting it from proteasomal degradation. (2004) (42)
- Yeast-Elicited Cross-Reactive Antibodies to HIV Env Glycans Efficiently Neutralize Virions Expressing Exclusively High-Mannose N-Linked Glycans (2010) (41)
- Simian Immunodeficiency Virus Utilizes Human and Sooty Mangabey but Not Rhesus Macaque STRL33 for Efficient Entry (2000) (41)
- AIDS models: Microbicides could learn from vaccines (2002) (40)
- Quantification of CD 4 , CCR 5 , and CXCR 4 levels on lymphocyte subsets , dendritic cells , and differentially conditioned monocyte-derived macrophages (1999) (39)
- Unique Pattern of Convergent Envelope Evolution in Simian Immunodeficiency Virus-Infected Rapid Progressor Macaques: Association with CD4-Independent Usage of CCR5 (2003) (38)
- Distinct presenilin‐dependent and presenilin‐independent γ‐secretases are responsible for total cellular Aβ production (2003) (36)
- Replication-Competent Variants of Human Immunodeficiency Virus Type 2 Lacking the V3 Loop Exhibit Resistance to Chemokine Receptor Antagonists (2007) (36)
- Multimeric CD4 binding exhibited by human and simian immunodeficiency virus envelope protein dimers (1992) (36)
- The neutralizing antibody response against West Nile virus in naturally infected horses. (2007) (36)
- Endoproteolysis of β-Secretase (β-Site Amyloid Precursor Protein-cleaving Enzyme) within Its Catalytic Domain (2003) (36)
- A Yeast Glycoprotein Shows High-Affinity Binding to the Broadly Neutralizing Human Immunodeficiency Virus Antibody 2G12 and Inhibits gp120 Interactions with 2G12 and DC-SIGN (2009) (36)
- Hemofiltrate CC Chemokine 1[9-74] Causes Effective Internalization of CCR5 and Is a Potent Inhibitor of R5-Tropic Human Immunodeficiency Virus Type 1 Strains in Primary T Cells and Macrophages (2002) (36)
- Kinetic studies of HIV-1 and HIV-2 envelope glycoprotein-mediated fusion (2006) (34)
- HIV-1 entry inhibitors: new targets, novel therapies. (2003) (34)
- Determinants within gp120 and gp41 contribute to CD4 independence of SIV Envs. (2004) (33)
- Closing in on the amyloid cascade: recent insights into the cell biology of Alzheimer's disease. (2000) (33)
- Amino Acid 324 in the Simian Immunodeficiency Virus SIVmac V3 Loop Can Confer CD4 Independence and Modulate the Interaction with CCR5 and Alternative Coreceptors (2004) (32)
- Functional impact of HIV coreceptor-binding site mutations. (2006) (31)
- Adaptive Mutations in a Human Immunodeficiency Virus Type 1 Envelope Protein with a Truncated V3 Loop Restore Function by Improving Interactions with CD4 (2009) (31)
- Induction of Antibodies in Guinea Pigs and Rhesus Monkeys against the Human Immunodeficiency Virus Type 1 Envelope: Neutralization of Nonpathogenic and Pathogenic Primary Isolate Simian/Human Immunodeficiency Virus Strains (2000) (31)
- β-Chemokine MDC and HIV-1 Infection (1998) (30)
- N-terminal substitutions in HIV-1 gp41 reduce the expression of non-trimeric envelope glycoproteins on the virus. (2008) (28)
- Efficient production of Hantaan and Puumala pseudovirions for viral tropism and neutralization studies. (2012) (27)
- Antibodies against Manalpha1,2-Manalpha1,2-Man oligosaccharide structures recognize envelope glycoproteins from HIV-1 and SIV strains. (2010) (27)
- CD4-Independent Use of Rhesus CCR5 by Human Immunodeficiency Virus Type 2 Implicates an Electrostatic Interaction between the CCR5 N Terminus and the gp120 C4 Domain (2001) (26)
- Stable secretion of a soluble, oligomeric form of rabies virus glycoprotein: influence of N-glycan processing on secretion. (1995) (26)
- Exploitation of the Vbeta8.2 T cell receptor in protection against experimental autoimmune encephalomyelitis using a live vaccinia virus vector. (1996) (26)
- Kruppel-like Factor 2 Modulates CCR5 Expression and Susceptibility to HIV-1 Infection (2012) (26)
- Enhanced Exposure of the CD 4-Binding Site to Neutralizing Antibodies by Structural Design of a Membrane-Anchored Human Immunodeficiency Virus Type 1 gp 120 Domain (2009) (26)
- Novel b-Secretase Cleavage of b-Amyloid Precursor Protein in the Endoplasmic Reticulum / Intermediate Compartment of NT 2 N Cells (1997) (26)
- Evolution of coreceptor use and CD4-independence in envelope clones derived from SIVsm-infected macaques. (2003) (25)
- Neurotoxic Traffic: Uncovering the Mechanics of Amyloid Production in Alzheimer's Disease (2001) (25)
- Identification and Characterization of a Potent, Selective Nonpeptide Agonist of the CC Chemokine Receptor CCR8 (2006) (25)
- 12 – Studies on the Mechanism of Membrane Fusion (1973) (25)
- N-glycosylation of human nicastrin is required for interaction with the lectins from the secretory pathway calnexin and ERGIC-53. (2006) (25)
- Structure and Function of CC-Chemokine Receptor 5 Homologues Derived from Representative Primate Species and Subspecies of the Taxonomic Suborders Prosimii and Anthropoidea (2003) (24)
- The bulk-flow hypothesis: not quite the end. (1995) (23)
- Baseline Resistance of Primary Human Immunodeficiency Virus Type 1 Strains to the CXCR4 Inhibitor AMD3100 (2008) (23)
- Modulation of HIV and SIV neutralization sensitivity by DC-SIGN and mannose-binding lectin. (2007) (23)
- Endoproteolysis of beta-secretase (beta-site amyloid precursor protein-cleaving enzyme) within its catalytic domain. A potential mechanism for regulation. (2003) (22)
- Mutations in the C3 region of human and simian immunodeficiency virus envelope have differential effects on viral infectivity, replication, and CD4-dependency. (2003) (21)
- Oligomerization and protein transport. (1990) (21)
- Chemokine receptors as HIV coreceptors: implications and interactions. (1998) (21)
- AIDS Vaccine Development (1998) (20)
- Unwelcome guests with master keys: how HIV enters cells and how it can be stopped. (2004) (20)
- Evaluation of current approaches to inhibit HIV entry. (2002) (19)
- Influence of the CCR 2V 64 I Polymorphism on Human Immunodeficiency Virus Type 1 Coreceptor Activity and on Chemokine Receptor Function of CCR 2 b , CCR 3 , CCR 5 , and CXCR 4 (1998) (19)
- Closing in on the amyloid cascade (2000) (19)
- Protein conformational changes in virus-cell fusion. (1993) (18)
- Expression of foreign proteins in a human neuronal system. (1994) (18)
- Platelet Factor 4 Inhibits and Enhances HIV-1 Infection in a Concentration-Dependent Manner by Modulating Viral Attachment. (2016) (18)
- Differential effects of the swedish mutant amyloid precursor protein on beta-amyloid accumulation and secretion in neurons and nonneuronal cells. (1998) (18)
- A Potent, Broad-Spectrum Antiviral Agent that Targets Viral Membranes (2010) (17)
- The assembly of the HIV-1 env glycoprotein into dimers and tetramers. (1991) (17)
- Properties of a Viral Fusion Protein (1988) (15)
- Opportunities and challenges in targeting HIV entry. (2002) (15)
- A Cell-Cell Fusion Assay to Monitor HIV-1 Env Interactions with Chemokine Receptors. (1999) (15)
- What Came First—the Virus or the Egg? (2017) (14)
- Gene Therapy Targeting HIV Entry (2014) (14)
- The impact of chemokine receptor conformational heterogeneity on HIV infection. (2001) (14)
- Antibodies elicited by yeast glycoproteins recognize HIV-1 virions and potently neutralize virions with high mannose N-glycans. (2015) (14)
- Embedding persuasive design for self-health management systems in Dutch healthcare informatics education: Application of a theory-based method (2018) (11)
- Distinct presenilin-dependent and presenilin-independent gamma-secretases are responsible for total cellular Abeta production. (2003) (11)
- DNA vaccine protection against challenge with simian/human immunodeficiency virus 89.6 in rhesus macaques. (2000) (11)
- HIV Transmission : Closing All the Doors (2004) (10)
- Chapter 3 Basic Concepts A Step-by-Step Guide to Viral Infection (2016) (9)
- Vaccinia virus serves as an efficient vector for expressing heterologous proteins in human NTera 2 neurons (1996) (9)
- Viral entry denied. (2004) (8)
- Inef fi cient entry of vicriviroc-resistant HIV-1 via the inhibitor-CCR 5 complex at low cell surface CCR 5 densities (2009) (7)
- HIV-1 gp 120 and chemokines activate ion channels in primary macrophages through CCR 5 and CXCR 4 stimulation (2000) (7)
- Dissecting the neutralizing antibody specificities of broadly neutralizing sera from 1 HIV-1 infected donors 2 * (2007) (7)
- Identification and Characterization of a Potent , Selective Nonpeptide Agonist of the CC Chemokine Receptor CCR 8 (2005) (6)
- Making Bunyaviruses Talk: Interrogation Tactics to Identify Host Factors Required for Infection (2016) (5)
- Simian Immunodeficiency Virus Utilizes Human and Sooty Mangabey but Not Rhesus Macaque STRL 33 for Efficient Entry (2000) (5)
- HIV entry: are all receptors created equal? (2002) (5)
- Fusion mediated by the HIV-1 envelope protein. (2000) (5)
- Quantifying Aβ(1-40) and Aβ (1-42) Using Sandwich-ELISA. (2000) (5)
- A Plea for Justice for Jailed Medical Workers (2006) (5)
- Prime, Boost, and Broaden (2010) (4)
- CHAPTER 33 – The Role of Chemokine Receptors in HIV Infection of Host Cells (2003) (4)
- A simian immunodeficiency virus V3 loop mutant that does not efficiently use CCR5 or common alternative coreceptors is moderately attenuated in vivo. (2007) (3)
- Quantification of HIV/SIV Coreceptor Expression (2001) (3)
- Comparative Evaluation of Choose Your Own Adventure and Traditional Linear Case Formats in Radiology Small Group Teaching. (2022) (2)
- HIV: much at stake with kidneys? (2000) (2)
- Interaction of human immunodeficiency virus type 1 envelope protein with liposomes containing galactosylceramide (1996) (2)
- Penetration of Influenza Virus Into Host Cells (1989) (2)
- Basic Concepts (2016) (1)
- Folding, Interaction withGRP78-BiP, Assembly, andTransport of theHumanImmunodeficiency VirusType1 Envelope Protein (1991) (1)
- Antibodies against Man α 1,2-Man α 1,2-Man oligosaccharide structures recognize envelope glycoproteins from HIV-1 and SIV strains (2010) (1)
- Dual roles for the cytoplasmic domain of the VSV G protein: Protein transport and virus assembly (1988) (1)
- Fusing HIV and Chemokine Receptors (2011) (1)
- BIOSYNTHESIS OF APP AND Aβ: MULTIPLE PATHWAYS FOR THE GENERATION OF INTRACELLULAR Aβ (1998) (1)
- Clinical Resistance to Enfuvirtide Does Not Affect Susceptibility of Human Immunodeficiency Virus Type 1 to Other Classes of Entry Inhibitors (cid:1) (2007) (1)
- HIV-1 Resistance to CCR5 Antagonists Associated with Highly Efficient Use of CCR5 and Altered Tropism on Primary CD4 (cid:1) T Cells (cid:1) (2010) (1)
- HIV-1 Coreceptors and Viral Tropism (1999) (0)
- Intracellular A-beta in neuronal and non-neuronal cells (2000) (0)
- Dissecting the Neutralizing Antibody Specificities of Broadly Neutralizing Sera from Human Immunodeficiency Virus Type 1-Infected Donors (cid:1) (2007) (0)
- Application of a theary-based method in educational programs for designing persuasive eHealth (2018) (0)
- P4-282 Association and localization of nicastrin influences the activity of the G-secretase complex (2004) (0)
- vaccinia virus with the cell membrane. Fusion of intra- and extracellular forms of (2013) (0)
- C106 Distinguishing Features of Transmitted/Founder HIV-1 (2013) (0)
- populations Multiple nonfunctional alleles of CCR5 are frequent in various human (2013) (0)
- InfectionExpression and Susceptibility to HIV-1 Kruppel-like Factor 2 Modulates CCR5 (2012) (0)
- Introduction to entry inhibitors in the management of HIV infection (2007) (0)
- CXCR 4 Envelope Glycoprotein That Confer Usage of Human Immunodeficiency Virus Type 1 Identification of Determinants on a Dualtropic (1998) (0)
- Human factors in designing persuasive eHealth to support self-management (2018) (0)
- Characterization ofHumanImmunodeficiency VirusType1 gpl20Binding toLiposomes Containing Galactosylceramide (1994) (0)
- Infection Expression and Susceptibility to HIV-1 Kruppel-like Factor 2 Modulates CCR 5 (2012) (0)
- Baseline Resistance of Primary Human Immunodeficiency Virus Type 1 Strains to the CXCR4 Inhibitor AMD3100 (cid:1) (2008) (0)
- Identification of a Novel C-Terminal Cleavage of Crimean-Congo Hemorrhagic Fever Virus PreG N That Leads to Generation of an NS M Protein (cid:1) (2007) (0)
- Application of a theory-based method in educational programs for designing persuasive eHealth : A Dutch experience (2018) (0)
- RECEPTOR DOMAINS INVOLVED IN THE INTERACTION WITH CHEMOKINES AND HIV (1999) (0)
- Alzheimer's disease: Targeting of Nicastrin to sub-cellular compartments and its influence on G-secretase complex activity (2005) (0)
- A New Generation of Antiviral Therapeutics Designed to Prevent the Use of Chemokine Receptors for Entry by HIV-1 (2002) (0)
- BACE overexpression alters the subcellular processing of APP and inhibits A (cid:1) deposition in vivo (2005) (0)
- Domotica in de zorg; hype of zinvol (2015) (0)
- efficient activation of intracellular signaling pathways (2001) (0)
- Eliciting broadly neutralizing antibodies to human immunodeficiency virus could bring closer the goal of a successful AIDS vaccine. Here the International AIDS Vaccine Initiative Neutralizing Antibody Consortium discusses current approaches to overcome the problems faced. (2004) (0)
- [Psychosomatic aspects in functional disorders of the temporomandibular joint]. (1969) (0)
- Table of Contents (1990) (0)
- Title : 1 A haploid genetic screen identifies heparan sulfate proteoglycans supporting Rift Valley fever 2 virus infection 3 Running title : 4 Haploid screen identifies RVFV entry factors 5 Authors : 6 (2015) (0)
- patient-derived and prototype isolates resulting immunodeficiency virus : resistance to macrophage-tropic strains of human macrophages and lymphocytes by Role of CCR 5 in infection of primary (1997) (0)
- Drug-Bound CCR 5 and Extracellular Loop Domains of Antagonists Depends on both N-Terminal Cross-Resistance to Other CCR 5 A Maraviroc-Resistant HIV-1 with Narrow (2010) (0)
- P4-319 Assembly, trafficking, and activity of the gamma-secretase complex (2004) (0)
- KLF 2 Modulates CCR 5 Expression and Susceptibility to HIV-1 Infection 1 (2012) (0)
- Structure-function relationships of CCR5 as a chemokine receptor and HIV co-receptor (1998) (0)
- Viral Membrane Proteins as Tools to Study Protein Folding, Assembly, and Transport (1995) (0)
- 176 Exploring the Potential of CCR5 and CXCR4 Modified CD4 T Cells to Target the HIV-1 Reservoir (2011) (0)
- J. Virol.-2011-Jiang-10669-81 (2012) (0)
- Hbo‐Master Advanced Health (2014) (0)
- Influenza Virus Hemagglutinin and Membrane Fusion (2019) (0)
- Functional characterization of novel G protein-coupled receptors involved in nociception and HIV-1 infection (1997) (0)
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