Roberta F. Colman
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American biochemist
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Roberta F. Colman's Degrees
- PhD Biochemistry Stanford University
- Masters Chemistry Stanford University
- Bachelors Chemistry Stanford University
Why Is Roberta F. Colman Influential?
(Suggest an Edit or Addition)According to Wikipedia, Roberta F. Colman , born Roberta Fishman, was an American biochemist. Early life Roberta Fishman was from New York City, the daughter of William and Esther Fishman of Brooklyn. As a student at Forest Hills High School in 1955, she received a Westinghouse Science Talent Search Award, and met president Dwight D. Eisenhower. Colman earned her bachelor's degree at Radcliffe College in 1959, and completed doctoral studies at Harvard University in 1962, with Frank Westheimer as her advisor. She held post-doctoral fellowships at the National Institutes of Health and the Washington University School of Medicine.
Roberta F. Colman's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Clopidogrel inhibits the binding of ADP analogues to the receptor mediating inhibition of platelet adenylate cyclase. (1992) (213)
- Direct evidence for the formation of a complex between 1-cysteine peroxiredoxin and glutathione S-transferase pi with activity changes in both enzymes. (2006) (174)
- Affinity labeling of purine nucleotide sites in proteins. (1983) (154)
- Insights from retinitis pigmentosa into the roles of isocitrate dehydrogenases in the Krebs cycle (2008) (153)
- Glutamate dehydrogenase concentration as a determinant in the effect of purine nucleotides on enzymatic activity. (1967) (115)
- Crystal Structure of Porcine Mitochondrial NADP+-dependent Isocitrate Dehydrogenase Complexed with Mn2+ and Isocitrate (2002) (110)
- Effect of modification of a methionyl residue on the kinetic and molecular properties of isocitrate dehydrogenase. (1968) (94)
- Affinity labeling of the inhibitory DPNH site of bovine liver glutamate dehydrogenase by 5'-fluorosulfonylbenzoyl adenosine. (1975) (86)
- Identification of adenine nucleotide binding proteins in human platelet membranes by affinity labeling with 5'-p-flurosulfonylbenzoyl adenosine. (1978) (85)
- High molecular weight kininogen inhibits thrombin-induced platelet aggregation and cleavage of aggregin by inhibiting binding of thrombin to platelets. (1991) (85)
- Affinity labeling of rabbit muscle pyruvate kinase by 5'-p-fluorosulfonylbenzoyladenosine. (1977) (77)
- Chemical characterization of distinct subunits of pig heart DPN-specific isocitrate dehydrogenase. (1980) (75)
- Diphosphopyridine nucleotide dependent isocitrate dehydrogenase from pig heart. Charactgerization of the active substrate and modes of regulation. (1972) (75)
- Adenylosuccinate lyase deficiency. (2006) (61)
- Subunit interface residues of glutathione S-transferase A1-1 that are important in the monomer-dimer equilibrium. (2004) (60)
- Platelet ADP receptor and alpha 2-adrenoreceptor interaction. Evidence for an ADP requirement for epinephrine-induced platelet activation and an influence of epinephrine on ADP binding. (1986) (60)
- On the role of amino groups in the structure and function of glutamate dehydrogenase. I. Effect of acetylation on catalytic and regulatory properties. (1966) (59)
- Role of metal ions in reactions catalyzed by pig heart triphosphopyridine nucleotide-dependent isocitrate dehydrogenase. II. Effect on catalytic properties and reactivity of amino acid residues. (1972) (53)
- On the role of amino groups in the structure and function of glutamate dehydrogenase. II. Effect of acetylation on molecular properties. (1966) (51)
- Thrombin-induced platelet aggregation involves an indirect proteolytic cleavage of aggregin by calpain. (1989) (50)
- Affinity labeling of a human platelet membrane protein with 5'-p-fluorosulfonylbenzoyl adenosine. Concomitant inhibition of ADP-induced platelet aggregation and fibrinogen receptor exposure. (1981) (49)
- Characterization of the complex of glutathione S-transferase pi and 1-cysteine peroxiredoxin. (2008) (48)
- Substrate and product complexes of Escherichia coli adenylosuccinate lyase provide new insights into the enzymatic mechanism. (2007) (48)
- Isolation and sequence of a cDNA encoding porcine mitochondrial NADP-specific isocitrate dehydrogenase. (1992) (47)
- Glutathione S-Transferase Pi Has at Least Three Distinguishable Xenobiotic Substrate Sites Close to Its Glutathione-binding Site* (2004) (47)
- The role of sulfhydryl groups in the catalytic function of isocitrate dehydrogenase. I. Reaction with 5,5'-dithiobis(2-nitrobenzoic acid). (1969) (46)
- Determination by gel filtration of association constants for metal-nucleotide interaction. (1972) (46)
- ON THE ROLE OF FLAVIN ADENINE DINUCLEOTIDE AND THIOL GROUPS IN THE CATALYTIC MECHANISM OF YEAST GLUTATHIONE REDUCTASE. (1965) (46)
- Identification of metal-isocitrate binding site of pig heart NADP-specific isocitrate dehydrogenase by affinity cleavage of the enzyme by Fe(2+)-isocitrate. (1993) (42)
- Two mechanisms for inhibition of ADP-induced platelet shape change by 5'-p-fluorosulfonylbenzoyladenosine. Conversion to adenosine, and covalent modification at an ADP binding site distinct from that which inhibits adenylate cyclase. (1985) (42)
- Adenosine derivatives for dehydrogenases and kinases. (1977) (40)
- GSTpi modulates JNK activity through a direct interaction with JNK substrate, ATF2 (2011) (39)
- Identification by Mutagenesis of Arginines in the Substrate Binding Site of the Porcine NADP-dependent Isocitrate Dehydrogenase* (2000) (38)
- Affinity labeling of an allosteric GTP site of bovine liver glutamate dehydrogenase by 5'-p-fluorosulfonylbenzoylguanosine. (1979) (38)
- Activation of bovine liver glutamate dehydrogenase by covalent reaction of adenosine 5'-O-[S-(4-bromo-2,3-dioxobutyl)thiophosphate] with arginine-459 at an ADP regulatory site. (1994) (38)
- His68 and His141 are critical contributors to the intersubunit catalytic site of adenylosuccinate lyase of Bacillus subtilis. (1999) (38)
- Critical Role of Lys212 and Tyr140 in Porcine NADP-dependent Isocitrate Dehydrogenase* (2003) (36)
- Reaction of the adenine nucleotide analogue 5'-p-fluorosulfonylbenzoyl adenosine at distinct tyrosine and cysteine residues of rabbit muscle pyruvate kinase. (1981) (36)
- Lysine and tyrosine in the NADH inhibitory site of bovine liver glutamate dehydrogenase. (1981) (35)
- Phosphorus-31 nuclear magnetic resonance studies of the binding of nucleotides to NADP+-specific isocitrate dehydrogenase. (1984) (35)
- Human heart TPN-specific isocitrate dehydrogenase. Purification by a rapid three-step procedure. (1977) (35)
- Modification of two essential cysteines in rabbit muscle pyruvate kinase by the guanine nucleotide analogue 5'[p-(fluorosulfonyl) benzoyl] guanosine. (1981) (35)
- The role of sulfhydryl groups in the catalytic function of isocitrate dehydrogenase. II. Effect of N-ethylmaleimide on kinetic properties. (1970) (35)
- Evaluation by site-directed mutagenesis of aspartic acid residues in the metal site of pig heart NADP-dependent isocitrate dehydrogenase. (2000) (35)
- Cysteinyl peptides of pig heart NADP-dependent isocitrate dehydrogenase that are modified upon inactivation by N-ethylmaleimide. (1991) (35)
- Physicochemical properties of the diphosphopyridine nucleotide-specific isocitrate dehydrogenase of pig heart. (1974) (34)
- Spectroscopic studies of the interactions of coenzymes and coenzyme fragments with pig heart, oxidized triphosphopyridine nucleotide specific isocitrate dehydrogenase. (1985) (34)
- Affinity labeling of a regulatory site of bovine liver glutamate dehydrogenase. (1975) (34)
- Role of metal ions in reactions catalyzed by pig heart triphosphopyridine nucleotide-dependent isocitrate dehydrogenase. I. Magnetic resonance and binding studies of the complexes of enzyme, manganous ion, and substrates. (1972) (33)
- Binding of ligands to half of subunits of NAD-dependent isocitrate dehydrogenase from pig heart. Binding of manganous ion, isocitrate, ADP and NAD. (1981) (33)
- Localization of human platelet membrane-associated actomyosin using the affinity label 5'-p-fluorosulfonylbenzoyl adenosine. (1981) (33)
- Affinity labeling of nicotinamide adenine dinucleotide dependent isocitrate dehydrogenase by the 2',3'-dialdehyde derivative of adenosine 5'-diphosphate. Evidence for the formation of an unusual reaction product. (1983) (32)
- Mechanisms for the oxidative decarboxylation of isocitrate: implications for control. (1975) (31)
- S-(4-Bromo-2,3-dioxobutyl)glutathione: a new affinity label for the 4-4 isoenzyme of rat liver glutathione S-transferase. (1991) (31)
- Heterodimers of glutathione S-transferase can form between isoenzyme classes pi and mu. (2001) (30)
- Affinity labeling of glutathione S-transferase, isozyme 4-4, by 4-(fluorosulfonyl)benzoic acid reveals Tyr115 to be an important determinant of xenobiotic substrate specificity. (1993) (30)
- Evaluation by Mutagenesis of the Importance of 3 Arginines in α, β, and γ Subunits of Human NAD-dependent Isocitrate Dehydrogenase* (2003) (29)
- Separation, recombination, and characterization of dissimilar subunits of the DPN-dependent isocitrate dehydrogenase from pig heart. (1983) (29)
- Isolation and identification of cysteinyl peptide labeled by 6- [( 4-bromo-2,3-dioxobutyl)thio]-6-deaminoadenosine 5'-diphosphate in the reduced diphosphopyridine nucleotide inhibitory site of glutamate dehydrogenase. (1986) (28)
- Re-evaluation of molecular weight of pig heart NAD-specific isocitrate dehydrogenase. (1981) (28)
- Substrate independence of molecular weight of triphosphopyridine nucleotide-specific isocitrate dehydrogenase. (1972) (28)
- Three subunits contribute amino acids to the active site of tetrameric adenylosuccinate lyase: Lys268 and Glu275 are required. (2002) (27)
- Affinity labeling of rabbit muscle pyruvate kinase by a new fluorescent nucleotide alkylating agent 5'-[p-(fluorosulfonyl)benzoyl]-1,N6-ethenoadenosine. (1981) (27)
- Pig heart triphosphopyridine nucleotide specific isocitrate dehydrogenase. A single polypeptide chain. (1970) (27)
- Guanosine 5'-O-[S-(4-bromo-2,3-dioxobutyl)]thiophosphate and adenosine 5'-O-[S-(4-bromo-2,3-dioxobutyl)]thiophosphate. New nucleotide affinity labels which react with rabbit muscle pyruvate kinase. (1994) (26)
- Ligands of the Mn2+ bound to porcine mitochondrial NADP-dependent isocitrate dehydrogenase, as assessed by mutagenesis. (2004) (26)
- Coenzyme binding by native and chemically modified pig heart triphosphopyridine nucleotide dependent isocitrate dehydrogenase. (1975) (26)
- Affinity labeling of a GTP site of glutamate dehydrogenase by fluorescent nucleotide analog 5'-[p-(fluorosulfonyl)benzoyl]-1,N6-ethenoadenosine (1982) (26)
- Identification of the lysine and tyrosine peptides labeled by 5'-p-fluorosulfonylbenzoyladenosine in the NADH inhibitory site of glutamate dehydrogenase. (1984) (25)
- Methionyl residue critical for activity and regulation of bovine liver glutamate dehydrogenase. (1973) (25)
- The absence of zinc in bovine liver glutamate dehydrogenase. (1970) (25)
- Identification of sites for feedback regulation of glutamine 5-phosphoribosylpyrophosphate amidotransferase by nucleotides and relationship to residues important for catalysis. (1993) (25)
- The role of arginine in the triphosphopyridine nucleotide dependent isocitrate dehydrogenase of pig heart. (1977) (25)
- Influence of substrates and coenzymes on the role of manganous ion in reactions catalyzed by pig heart triphosphopyridine nucleotide-dependent isocitrate dehydrogenase. (1976) (24)
- Role of α-Asp181, β-Asp192, and γ-Asp190 in the Distinctive Subunits of Human NAD-Specific Isocitrate Dehydrogenase† (2007) (24)
- Cooperative interaction between the GTP binding sites of glutamate dehydrogenase. (1966) (24)
- Cysteine in the manganous-isocitrate binding site of pig heart TPN-specific isocitrate dehydrogenase. I. Kinetics of chemical modification and properties of thiocyano enzyme. (1981) (24)
- Cleavage of a 100 kDa membrane protein (aggregin) during thrombin-induced platelet aggregation is mediated by the high affinity thrombin receptors. (1989) (24)
- A glutamyl residue in the active site of triphosphopyridine nucleotide-dependent isocitrate dehydrogenase of pig heart. (1973) (24)
- Two Novel Mutant Human Adenylosuccinate Lyases (ASLs) Associated with Autism and Characterization of the Equivalent Mutant Bacillus subtilis ASL* (2004) (24)
- Identification of His141 in the Active Site of Bacillus subtilis Adenylosuccinate Lyase by Affinity Labeling with 6-(4-Bromo2,3-dioxobutyl)thioadenosine 5′-Monophosphate* (1997) (23)
- Affinity labeling of NADP+-specific isocitrate dehydrogenase by a new fluorescent nucleotide analogue, 2-[(4-bromo-2,3-dioxobutyl)thio]-1,N6-ethenoadenosine 2',5'-bisphosphate. (1985) (23)
- 1H nuclear magnetic resonance studies of the conformation and environment of nucleotides bound to pig heart NADP+-dependent isocitrate dehydrogenase. (1985) (23)
- Identification of Mn2+-binding Aspartates from α, β, and γ Subunits of Human NAD-dependent Isocitrate Dehydrogenase* (2006) (23)
- Affinity labeling of the active site of yeast pyruvate kinase by 5'-p-fluorosulfonylbenzoyl adenosine. (1980) (23)
- Interrelationships among nucleotide binding sites of pig heart NAD-dependent isocitrate dehydrogenase. (1982) (23)
- 6 Site-Specific Modification of Enzyme Sites (1990) (22)
- Histidine in the nucleotide-binding site of NADP-linked isocitrate dehydrogenase from pig heart. (1978) (22)
- Binding of substrates by native and chemically modified isocitrate dehydrogenase. (1969) (22)
- Effect of arginine modification on the catalytic activity and allosteric activation by adenosine diphosphate of the diphosphopyridine nucleotide specific isocitrate dehydrogenase of pig heart. (1978) (22)
- Deuterium solvent isotope effects in reactions catalyzed by isocitrate dehydrogenase (1969) (22)
- Characterization of the physicochemical and catalytic properties of human heart NADP-dependent isocitrate dehydrogenase. (1978) (22)
- Probing Subunit Interactions in Alpha Class Rat Liver Glutathione S-Transferase with the Photoaffinity Label Glutathionyl S-[4-(Succinimidyl)benzophenone]* (2000) (22)
- Modification of TPN-dependent isocitrate dehydrogenase by the 2', 3'-dialdehyde derivatives of TPNH and TPN. (1983) (22)
- 6-[(4-bromo-2,3-dioxobutyl)thio]-6-deaminoadenosine 5'-monophosphate and 5'-diphosphate: new affinity labels for purine nucleotide sites in proteins. (1984) (21)
- Role of manganous ion in the kinetics of pig-heart NAD-specific isocitrate dehydrogenase. (1974) (21)
- Catalytically Active Monomer of Glutathione S-Transferase π and Key Residues Involved in the Electrostatic Interaction between Subunits* (2008) (21)
- Identification of the nonsubstrate steroid binding site of rat liver glutathione S-transferase, isozyme 1-1, by the steroid affinity label, 3beta-(iodoacetoxy)dehydroisoandrosterone. (1997) (21)
- The characterization of mutant Bacillus subtilis adenylosuccinate lyases corresponding to severe human adenylosuccinate lyase deficiencies (2003) (21)
- Characterization of a mutant Bacillus subtilis adenylosuccinate lyase equivalent to a mutant enzyme found in human adenylosuccinate lyase deficiency: asparagine 276 plays an important structural role. (2003) (21)
- Identification of amino acids modified by the bifunctional affinity label 5'-(p-(fluorosulfonyl)benzoyl)-8-azidoadenosine in the reduced coenzyme regulatory site of bovine liver glutamate dehydrogenase. (1992) (20)
- Cyanate modification of essential lysyl residues of the diphosphopyridine nucleotide-specific isocitrate dehydrogenase of pig heart. (1975) (20)
- Subunit location and sequences of the cysteinyl peptides of pig heart NAD-dependent isocitrate dehydrogenase. (1990) (20)
- Plasmin-induced platelet aggregation is accompanied by cleavage of aggregin and indirectly mediated by calpain. (1990) (19)
- Implication by site-directed mutagenesis of Arg314 and Tyr316 in the coenzyme site of pig mitochondrial NADP-dependent isocitrate dehydrogenase. (2002) (19)
- Conformations of the coenzymes and the allosteric activator, ADP, bound to NAD(+)-dependent isocitrate dehydrogenase from pig heart. (1990) (19)
- Implication of His68 in the substrate site of Bacillus subtilis adenylosuccinate lyase by mutagenesis and affinity labeling with 2-[(4-bromo-2,3-dioxobutyl)thio]adenosine 5'-monophosphate. (1998) (19)
- Frequency and temperature dependence of the proton relaxation rates of solvent and substrate interaction with isocitrate dehydrogenase bound Mn(II). (1974) (19)
- Evaluation of the intramolecular stacking of the fluorosulfonylbenzoyl derivatives of 1,N6-ethenoadenosine, adenosine, and guanosine. (1984) (19)
- Affinity labeling of AMP-ADP sites in heart phosphofructokinase by 5-p-fluorosulfonylbenzoyl adenosine. (1978) (19)
- 2-[(4-Bromo-2,3-dioxobutyl)thio]-1,N6-ethenoadenosine 5'-diphosphate. A new fluorescent affinity label of a tyrosyl residue in the active site of rabbit muscle pyruvate kinase. (1989) (19)
- The importance of arginine residues in the catalytic and regulatory functions of bovine-liver glutamate dehydrogenase. (1976) (19)
- Affinity labeling of the allosteric ADP activation site of NAD-dependent isocitrate dehydrogenase by 6-(4-bromo-2,3-dioxobutyl)thioadenosine 5'-diphosphate. (1984) (19)
- The Role of Sulfhydryl Groups in the Catalytic Function of Isocitrate Dehydrogenase III. EFFECT OF N-ETHYLMALEIMIDE ON CHEMICAL AND PHYSICAL PROPERTIES (1970) (19)
- Monobromobimane occupies a distinct xenobiotic substrate site in glutathione S‐transferase π (2003) (19)
- Biochemical and biophysical analysis of five disease-associated human adenylosuccinate lyase mutants. (2009) (19)
- Expression, purification, and characterization of stable, recombinant human adenylosuccinate lyase. (2007) (18)
- Ionization of isocitrate bound to pig heart NADP+-dependent isocitrate dehydrogenase: 13C NMR study of substrate binding. (1987) (18)
- Evidence for the presence of two nonidentical subunits in NAD-dependent isocitrate dehydrogenase of pig heart. (1978) (18)
- A key role in catalysis for His89 of adenylosuccinate lyase of Bacillus subtilis. (2000) (17)
- Expression of pig heart mitochondrial NADP-dependent isocitrate dehydrogenase in Escherichia coli. (1996) (17)
- Inhibition of ADP-induced Platelet Responses by Covalent Modification of Aggregin, a Putative ADP Receptor, by 8-(4-Bromo-2,3-dioxobutylthio)ADP (*) (1995) (17)
- Three new potential cAMP affinity labels. Inactivation of human platelet low Km cAMP phosphodiesterase by 8-[(4-bromo-2,3-dioxobutyl)thio]adenosine 3',5'-cyclic monophosphate. (1990) (17)
- Communication between the two active sites of glutathione S-transferase A1-1, probed using wild-type-mutant heterodimers. (2005) (17)
- Purification of NAD-specific isocitrate dehydrogenase from porcine heart. (1971) (17)
- Distinction between glycoprotein IIIa and the 100-kDa membrane protein (aggregin) mediating ADP-induced platelet activation. (1988) (17)
- Evaluation by mutagenesis of the roles of His309, His315, and His319 in the coenzyme site of pig heart NADP-dependent isocitrate dehydrogenase. (2002) (17)
- [202] Glutathione reductase (Yeast)☆ (1971) (17)
- Resonance energy transfer between the adenosine 5'-diphosphate site of glutamate dehydrogenase and a guanosine 5'-triphosphate site containing a tyrosine labeled with 5'-[p-(fluorosulfonyl)benzoyl]-1,N6-ethenoadenosine. (1983) (16)
- Studies on Diastereoisomeric α-Amino Acids and Corresponding α-Hydroxy Acids. X. The Preparation of β-Hydroxy-β-methylaspartic Acid (1959) (16)
- Reaction of pyruvate kinase with the new nucleotide affinity labels 8-[(4-bromo-2,3-dioxobutyl)thio]adenosine 5'-diphosphate and 5'-triphosphate. (1988) (16)
- Direct evidence for the interaction of the nucleotide affinity analog 5'-p-fluorosulfonylbenzoyl adenosine with a platelet ADP receptor. (1987) (16)
- Photoaffinity labeling of rat liver glutathione S-transferase, 4-4, by glutathionyl S-[4-(succinimidyl)-benzophenone]. (1998) (16)
- Catalytically active monomer of class mu glutathione transferase from rat. (2006) (16)
- Affinity labeling of Cys111 of glutathione S-transferase, isoenzyme 1-1, by S-(4-bromo-2,3-dioxobutyl)glutathione. (1992) (16)
- Aspartyl peptide labeled by 2-(4-bromo-2,3-dioxobutylthio)adenosine 5'-diphosphate in the allosteric ADP site of pig heart NAD+-dependent isocitrate dehydrogenase. (1989) (16)
- Affinity Labeling of Rat Glutathione S-Transferase Isozyme 1-1 by 17β-Iodoacetoxy-estradiol-3-sulfate* (2001) (16)
- 3-Methyleneoxindole: an affinity label of glutathione S-transferase pi which targets tryptophan 38. (2001) (16)
- Isolation of the glutamyl peptide labeled by the nucleotide analogue 2-(4-bromo-2,3-dioxobutylthio)-1,N(6)-ethenoadenosine 2',5'-biphosphate in the active site of NADP+-specific isocitrate dehydrogenase. (1987) (16)
- New Insights from the Structure-Function Analysis of the Catalytic Region of Human Platelet Phosphodiesterase 3A (2006) (15)
- Monobromobimane as an Affinity Label of the Xenobiotic Binding Site of Rat Glutathione S-Transferase 3-3 (*) (1995) (15)
- Evidence for a methionyl residue in the active site of isocitrate dehydrogenase. (1967) (15)
- Contribution of the mu loop to the structure and function of rat glutathione transferase M1‐1 (2006) (15)
- Effect of a new non‐cleavable substrate analog on wild‐type and serine mutants in the signature sequence of adenylosuccinate lyase of Bacillus subtilis and Homo sapiens (2008) (15)
- Involvement of arginine 143 in nucleotide substrate binding at the active site of adenylosuccinate synthetase from Escherichia coli. (1996) (14)
- Distances among coenzyme and metal sites of NADP+-dependent isocitrate dehydrogenase using resonance energy transfer. (1987) (14)
- Evaluation by mutagenesis of the importance of 3 arginines in alpha, beta, and gamma subunits of human NAD-dependent isocitrate dehydrogenase. (2003) (14)
- 2-[(4-Bromo-2,3-dioxobutyl)thio]adenosine 5'-monophosphate, a new nucleotide analogue that acts as an affinity label of pyruvate kinase. (1985) (14)
- A new affinity label for guanosine nucleotide sites in proteins. (1978) (13)
- Each Conserved Active Site Tyr in the Three Subunits of Human Isocitrate Dehydrogenase Has a Different Function* (2010) (13)
- Cysteinyl peptides of rabbit muscle pyruvate kinase labeled by the affinity label 8-[(4-bromo-2,3-dioxobutyl)thio]adenosine 5'-triphosphate. (1990) (13)
- The reaction of 4-iodoacetamidosalicylic acid with TPN-dependent isocitrate dehydrogenase from pig heart. (1981) (13)
- Purification of nucleosidyl peptides by chromatography on dihydroxyboryl-substituted polyacrylamide and cellulose. (1979) (13)
- Inactivation of NAD-dependent isocitrate dehydrogenase by affinity labeling of the allosteric ADP site by 2-(4-bromo-2,3-dioxobutylthio)adenosine 5'-diphosphate. (1986) (13)
- Kinetic isotope effects in the NAD‐ and NADP‐specific isocitrate dehydrogenases of pig heart (1974) (13)
- Chemical modification of enzymes: critical evaluation of the graphical correlation between residual enzyme activity and number of groups modified. (1980) (13)
- Affinity labeling of a glutamyl peptide in the coenzyme binding site of NADP+-specific glutamate dehydrogenase of Salmonella typhimurium by 2-[(4-bromo-2,3-dioxobutyl)thio]-1,N6-ethenoadenosine 2',5'-bisphosphate. (1989) (13)
- Chemical arrows for enzymatic targets (1997) (13)
- Isolation and identification of a tyrosyl peptide labeled by 5'-[p-(fluorosulfonyl)benzoyl]-1,N6-ethenoadenosine at a GTP site of glutamate dehydrogenase. (1984) (12)
- 5'-p-fluorosulfonyl)benzoyl-8-azidoadenosine: a new bifunctional affinity label for nucleotide binding sites in proteins. (1989) (12)
- Guanosine 5'-O-[S-(3-bromo-2-oxopropyl)]thiophosphate: a new reactive purine nucleotide analog labeling Met-169 and Tyr-262 in bovine liver glutamate dehydrogenase. (1992) (12)
- Inactivation of recombinant monocyte cAMP-specific phosphodiesterase by cAMP analog, 8-[(4-bromo-2,3-dioxobutyl)thio]adenosine 3',5'-cyclic monophosphate. (1997) (12)
- Evidence for a critical glutamyl and an aspartyl residue in the function of pig heart diphosphopyridine nucleotide dependent isocitrate dehydrogenase. (1977) (12)
- Tyrosine 8 contributes to catalysis but is not required for activity of rat liver glutathione S‐transferase, 1–1 (1996) (12)
- Heterocyclic studies. Part XXXIX. Ring cleavage of some pyrimidine derivatives in alkali (1976) (12)
- Activation by phosphorylation and purification of human c-Jun N-terminal kinase (JNK) isoforms in milligram amounts. (2011) (11)
- Heterodimers of wild‐type and subunit interface mutant enzymes of glutathione S‐transferase A1–1: Interactive or independent active sites? (2004) (11)
- Gln212, Asn270, and Arg301 are critical for catalysis by adenylosuccinate lyase from Bacillus subtilis. (2004) (11)
- Ser95, Asn97, and Thr78 are important for the catalytic function of porcine NADP‐dependent isocitrate dehydrogenase (2005) (11)
- Thr373, Asp375, and Lys260 are in the coenzyme site of porcine NADP-dependent isocitrate dehydrogenase. (2006) (11)
- 3-Bromo-2-ketoglutarate: a substrate and affinity label for diphosphopyridine nucleotide dependent isocitrate dehydrogenase. (1982) (11)
- Affinity Labeling of the active site of rabbit muscle adenylosuccinate lyase by 2-[(4-bromo-2.3-dioxobutyl)thio] adenosine 5'-monophosphate. (1996) (11)
- Location of the Coenzyme Binding Site in the Porcine Mitochondrial NADP-dependent Isocitrate Dehydrogenase* (2005) (11)
- Novel Use of a Selenoalkyne Within Untraditionally Mild Dötz Benzannulation Processes; Total Synthesis of a Calceolaria andina L. Natural Hydroxylated Naphthoquinone (2001) (11)
- Affinity labeling of the reduced diphosphopyridine nucleotide inhibitory site of glutamate dehydrogenase by 6-[(4-bromo-2,3-dioxobutyl)thio]-6-deaminoadenosine 5'-diphosphate. (1984) (10)
- Affinity labeling of an allosteric ADP site of glutamate dehydrogenase by 2-(4-bromo-2,3-dioxobutylthio)adenosine 5'-monophosphate. (1986) (10)
- Identification of cysteine-319 as the target amino acid of 8-[(4-bromo-2,3-dioxobutyl)thio]adenosine 5'-triphosphate in bovine liver glutamate dehydrogenase. (1991) (10)
- Importance of lysine-286 at the NADP site of glutamate dehydrogenase from Salmonella typhimurium. (1992) (10)
- Affinity labeling of pig lung glutathione S-transferase pi by 4-(fluorosulfonyl)benzoic acid. (1999) (9)
- Identification of Tyr115 labeled by S-(4-bromo-2,3-dioxobutyl)glutathione in the hydrophobic substrate binding site of glutathione S-transferase, isoenzyme 3-3. (1992) (9)
- 8-(4-Bromo-2,3-dioxobutylthio)NAD: a new affinity label for NAD-specific isocitrate dehydrogenase. (1994) (9)
- Cysteine in the manganous-isocitrate binding site of pig heart TPN-specific isocitrate dehydrogenase. II. Identification of a critical cysteine-containing tryptic peptide derived from the thiocyano enzyme. (1981) (9)
- Characterization of an active site peptide modified by the substrate analogue 3-bromo-2-ketoglutarate on a single chain of dimeric NADP+-dependent isocitrate dehydrogenase. (1987) (9)
- Reaction of 5'-p-fluorosulfonylbenzoyl-1,N6-ethenoadenosine with histidine and cysteine residues in the active site of rabbit muscle pyruvate kinase. (1985) (9)
- Identification of Mn2+-binding aspartates from alpha, beta, and gamma subunits of human NAD-dependent isocitrate dehydrogenase. (2006) (9)
- Identification of the subunits and target peptides of pig heart NAD-specific isocitrate dehydrogenase modified by the affinity label 8-(4-bromo-2,3-dioxobutylthio)NAD. (1997) (9)
- Inactivation of platelet PDE2 by an affinity label: 8-[(4-bromo-2, 3-dioxobutyl)thio]cAMP. (2000) (9)
- Inactivation of phosphoenolpyruvate carboxykinase by the guanosine nucleotide analogue, 5'-p-fluorosulfonylbenzoyl guanosine. (1981) (9)
- Observations on coronary sinus rhythm and its mechanism (1961) (9)
- Probing the active site of α‐class rat liver glutathione S‐transferases using affinity labeling by monobromobimane (1997) (9)
- Affinity labeling of a lysine residue in the coenzyme binding site of pig heart mitochondrial malate dehydrogenase. (1979) (9)
- Identification of tyrosine 79 in the tocopherol binding site of glutathione S-transferase pi. (2006) (9)
- Multinuclear NMR studies of the divalent metal binding site of NADP-dependent isocitrate dehydrogenase from pig heart. (1989) (8)
- Affinity cleavage at the divalent metal site of porcine NAD‐specific isocitrate dehydrogenase (2008) (8)
- Identification of tyrosine and lysine peptides labeled by 5'-p-fluorosulfonylbenzoyl adenosine in the active site of pyruvate kinase. (1986) (8)
- Important roles of hydroxylic amino acid residues in the function of Bacillus subtilis adenylosuccinate lyase (2007) (8)
- 3,4-Didehydro-2-ketoglutarate: an affinity label for diphosphopyridine nucleotide dependent isocitrate dehydrogenase. (1982) (8)
- Adenosine 5'-0-[S-(4-succinimidyl-benzophenone)thiophosphate]: a new photoaffinity label of the allosteric ADP site of bovine liver glutamate dehydrogenase. (2001) (8)
- Identification of two distinct adenosine diphosphate receptors in human platelets. (1980) (8)
- Identification of histidyl peptide labeled by 2-(4-bromo-2,3-dioxobutylthio)adenosine 5'-monophosphate in an ADP regulatory site of glutamate dehydrogenase. (1989) (8)
- Selectivity in the binding of NAD(P)+ analogues to NAD- and NADP-dependent pig heart isocitrate dehydrogenases. A nuclear magnetic resonance study. (1992) (8)
- 2-[(4-Bromo-2,3-dioxobutyl)thio]- and 2-[(3-bromo-2-oxopropyl)thio]adenosine 2'5'-bisphosphate: new nucleotide analogues that act as affinity labels of nicotinamide adenine dinucleotide phosphate specific isocitrate dehydrogenase. (1987) (8)
- Alkylation of cysteinyl residues of pig heart NAD-specific isocitrate dehydrogenase by iodoacetate. (1976) (8)
- Cadmium-113 and magnesium-25 NMR study of the divalent metal binding sites of isocitrate dehydrogenases from pig heart. (1995) (7)
- Distance relationships between the catalytic site labeled with 4-(iodoacetamido)salicylic acid and regulatory sites of glutamate dehydrogenase. (1984) (7)
- Reaction of the 2',3'-dialdehyde derivative of NADPH at a nucleotide site of bovine liver glutamate dehydrogenase. (1986) (7)
- Resonance energy transfer between sites in rat liver glutathione S-transferase, 1-1, selectively modified at cysteine-17 and cysteine-111. (1997) (7)
- Evaluation of cysteine 283 and glutamic acid 284 in the coenzyme binding site of Salmonella typhimurium glutamate dehydrogenase by site-directed mutagenesis and reaction with the nucleotide analogue 2-[4-bromo-2,3-dioxobutyl)thio)-1,N6-ethenoadenosine 2',5'-bisphosphate. (1991) (7)
- Activity associated with individual subunits of pig heart NAD-specific isocitrate dehydrogenase. (1982) (7)
- Synthesis, characterization, and reactions of 2′-, 3′-, and 5′-(2-bromoethyl)-AMP: Potential affinity labels for nucleotide binding sites in enzymes (1982) (7)
- Chemical modification A probe of the structure and function of the subunits of DPN-dependent isocitrate dehydrogenase. (1982) (6)
- In vitro hybridization and separation of hybrids of human adenylosuccinate lyase from wild-type and disease-associated mutant enzymes. (2011) (6)
- Reaction of essential lysyl residues of pig heart diphosphyridine nucleotide dependent isocitrate dehydrogenase with 2,4-pentanedione. (1977) (6)
- Role of alpha-Asp181, beta-Asp192, and gamma-Asp190 in the distinctive subunits of human NAD-specific isocitrate dehydrogenase. (2007) (6)
- Cysteinyl peptide labeled by 3-bromo-2-ketoglutarate in the active site of pig heart NAD+-dependent isocitrate dehydrogenase. (1989) (6)
- Inactivation of pig heart NADP-specific isocitrate dehydrogenase by two affinity reagents is due to reaction with a cysteine not essential for function. (1992) (6)
- Alkylation of methionine in human heart TPN-dependent isocitrate dehydrogenase. (1979) (6)
- Advances in Affinity Labeling of Purine Nucleotide Sites in Dehydrogenases (1987) (5)
- Distance between the substrate and regulatory reduced coenzyme binding sites of bovine liver glutamate dehydrogenase by resonance energy transfer. (1990) (5)
- Evaluation of types of interactions in subunit association in Bacillus subtilis adenylosuccinate lyase. (2008) (5)
- The Role of Sulfhydryl Groups in the Catalytic Function of Isocitrate Dehydrogenase (1970) (5)
- Delineation of xenobiotic substrate sites in rat glutathione S‐transferase M1‐1 (2005) (5)
- Affinity labeling of bovine liver glutamate dehydrogenase with 8-[(4-bromo-2,3-dioxobutyl)thio]adenosine 5'-diphosphate and 5'-triphosphate. (1990) (5)
- N-ethylmaleimide profiling of yeast NADP-dependent isocitrate dehydrogenase. (1995) (5)
- Aggregin: the platelet receptor mediating activation by ADP. (1988) (5)
- Platelet activation by 2-(4-bromo-2,3-dioxobutylthio)adenosine 5'-diphosphate is mediated by its binding to a putative ADP receptor, aggregin. (1996) (4)
- REGULATION OF ENZYMES BY SMALL MOLECULES * (1972) (4)
- Insights from Affinity Labeling into Nucleotide- and Coenzyme-Dependent Enzyme Catalysis and Regulation (2006) (4)
- Affinity labels for NAD(P)-specific sites. (1997) (4)
- Adenosine 5'-(2-bromoethyl)-phosphate. A new affinity label for adenine nucleotide sites in proteins. (1980) (4)
- The kinetics of NAD-linked isocitrate dehydrogenase from calf heart. (1974) (3)
- Affinity labeling of a guanosine 5'-triphosphate site of glutamate dehydrogenase by a fluorescent nucleotide analogue, 5'-[p-(fluorosulfonyl)benzoyl]-1,N6-ethenoadenosine. (1982) (3)
- Affinity labeling of nucleotide binding sites of enzymes and platelets. (1990) (3)
- Chemical modification at subunit 1 of rat kidney Alpha class glutathione transferase with 2,3,5,6-tetrachloro-1,4-benzoquinone: close structural connectivity between glutathione conjugation activity and non-substrate ligand binding. (2006) (3)
- Affinity labels and spectroscopic probes of porcine heart NADP-dependent isocitrate dehydrogenase. (1989) (3)
- The role of dissimilar subunits of NAD-specific isocitrate dehydrogenase from pig heart. Evaluation using affinity labeling. (1984) (3)
- Effect of Asp69 and Arg310 on the pK of His68, a key catalytic residue of adenylosuccinate lyase (2007) (3)
- Implication of arginine-131 and arginine-303 in the substrate site of adenylosuccinate synthetase of Escherichia coli by affinity labeling with 6-(4-bromo-2,3-dioxobutyl)thioadenosine 5'-monophosphate. (1999) (3)
- Synthesis and characterization of iodopropyl derivatives of adenosine 3′,5′-cyclic-monophosphate: Potential affinity labels of cAMP binding sites in enzymes (1983) (3)
- Modulation of platelet responses by 2-[3-(bromo-2-oxopropylthio)]adenosine-5'-diphosphate involves its binding to as well as covalent modification of an ADP-receptor, aggregin. (1997) (3)
- Reaction of the nucleotide analogue 2-[(4-bromo-2,3-dioxobutyl)thio]adenosine 2',5'-bisphosphate at the coenzyme site of wild-type and mutant NADP(+)-specific glutamate dehydrogenases from Salmonella typhimurium. (1992) (3)
- Identification of the subunit and important target peptides of pig heart NAD-dependent isocitrate dehydrogenase modified by the affinity label adenosine 5'-O-[S-(4-bromo-2, 3-dioxobutyl)thiophosphate]. (1998) (3)
- Modification of NAD-dependent isocitrate dehydrogenase by the 2',3'-dialdehyde derivatives of NAD, NADH, NADP, and NADPH. (1988) (2)
- A new nonhydrolyzable reactive cAMP analog, (Sp)-adenosine-3',5'-cyclic-S-(4-bromo-2,3-dioxobutyl)monophosphorothioate irreversibly inactivates human platelet cGMP-inhibited cAMP phosphodiesterase. (2002) (2)
- Evidence for distinguishable sites of attack in the reactions of 5'-p-fluorosulfonylbenzoyl adenosine and 5'-p-fluorosulfonylbenzoyl guanosine with rabbit muscle pyruvate kinase. (1982) (2)
- Low-Km cyclic AMP phosphodiesterase from human platelets. Stimulation of activity by phosphorylation of the enzyme and affinity labeling of the active site. (1992) (2)
- Crystallization and preliminary diffraction analysis of porcine heart mitochondrial NADP(+)-dependent isocitrate dehydrogenase. (1996) (2)
- The role of sulfhydryl groups in the catalytic function of isocitrate dehydrogenase. 3. Effect of N-ethylmaleimide on chemical and physical properties. (1970) (2)
- Affinity Labeling of Adenine Nucleotide Sites in Enzymes (1990) (2)
- [Majocchi's granuloma of the beard caused by Trichophyton rubrum]. (1974) (2)
- ADP Binding Proteins in Thrombasthenic Platelet Membranes (1977) (2)
- Nicotinamide ribose 5'-O-[S-(3-bromo-2-oxopropyl)]thiophosphate: a new affinity label for NMN sites in enzymes. (1993) (2)
- A new nonhydrolyzable reactive cGMP analogue, (Rp)-guanosine-3',5'-cyclic-S-(4-bromo-2,3-dioxobutyl)monophosphorothioate, which targets the cGMP binding site of human platelet PDE3A. (2008) (2)
- PHOTOLYSIS OF PHENYL AZIDE IN THE PRESENCE OF ′NAKED′ ANIONS (1981) (2)
- Probing subunit interactions in glutathione S-transferases using affinity labeling (2001) (2)
- A nonhydrolyzable reactive cAMP analogue, (S(p))-8-[(4-bromo-2,3-dioxobutyl)thio]adenosine 3',5'-cyclic S-(methyl)monophosphorothioate, irreversibly inactivates human platelet cGMP-inhibited cAMP phosphodiesterase at micromolar concentrations. (2002) (2)
- Affinity labeling and related approaches to targeting specific enzyme sites. (1995) (2)
- Separation of the 100-kDa membrane protein mediating ADP-induced platelet shape change and activation from glycoprotein IIIa. (1986) (2)
- Inhibition of thrombin-induced platelet aggregation by high molecular weight kininogen. (1987) (2)
- Mutations of the {beta}-subunit of human NAD-specific isocitrate dehydrogenase in patients with Retinitis Pigmentosa (2008) (1)
- Novel Use of a Selenoalkyne Within Untraditionally Mild Doetz Benzannulation Processes; Total Synthesis of a Calceolaria andina L. Natural Hydroxylated Naphthoquinone. (2002) (1)
- Targeting enzyme sites in pyruvate kinase, glutamate dehydrogenase and glutathione S-transferase (1994) (1)
- Deuterium solvent isotope effects in reactions catalyzed. (1969) (1)
- Adenosine 2'-monophosphate, 5'-O-[S-(4-succinimidylbenzophenone)-thiophosphate]: a new photoaffinity label for the coenzyme site of porcine NADP-specific isocitrate dehydrogenase. (2005) (1)
- 8-(4-Bromo-2,3-dioxobutylthio)guanosine 5'-triphosphate: a new affinity label for purine nucleotide sites in proteins. (1999) (1)
- function of porcine NADP-dependent isocitrate dehydrogenase (2007) (1)
- Cysteinyl peptides labeled by dibromobutanedione in reaction with rabbit muscle pyruvate kinase (1992) (1)
- Cadmium 113 and carbon 13 NMR studies of ligand binding to pig heart NADP-dependent isocitrate dehydrogenase (1986) (1)
- Evaluation of Types of Interactions in Subunit Association in Bacillus subtilis Adenylosuccinate Lyase (ASL) (2007) (0)
- Interaction of nucleotide affinity analog 5'-p-fluorosulfonylbenzoyladenosine with platelet ADP receptor: aggregin. (1992) (0)
- A new nonhydrolyzable affinity label Rp‐cGMPS‐BDB targets the cGMP binding site of human platelet PDE3A (2006) (0)
- Affinity labeling of rat GST A1-1 by 3β-(iodoacetoxy)dehydroisoandrosterone (1999) (0)
- Mutations of the β‐subunit of human NAD‐specific isocitrate dehydrogenase in patients with Retinitis Pigmentosa (2008) (0)
- porcine NADP-dependent isocitrate dehydrogenase are important for the catalytic function of 78 , and Thr 97 , Asn 95 Ser (2004) (0)
- Direct Evidence for Complex Formation Between 1‐Cys Peroxiredoxin and Glutathione S‐Transferase pi (2006) (0)
- Kinetic isotope effects in the NAD‐ and NADP‐specific isocitrate dehydrogenases of pig heart (0)
- PURINE NUCLEOTIDE SITES IN DEHYDROGENASES (1987) (0)
- A Defect in the Krebs Cycle in Retinitis Pigmentosa (2008) (0)
- ARG-131 and ARG-303 in substrate site of adenylosuccinate synthetase of E coli by affinity labeling with 6- thioadenosine 5-monophosphate (1998) (0)
- Identification of 2 novel mutant human adenylosuccinate lyases(ASL) associated with autism and characterization of the equivalent mutant B-subtilis ASL (2004) (0)
- Characterization and Hybridization of Disease‐Associated Human Adenylosuccinate Lyase Mutants (2009) (0)
- Chemical modification of enzymes: Critical evaluation of the graphical correlation between residual enzyme activity and number of groups modified (1980) (0)
- New Insights from the Structure Function of the Catalytic Region of Human Platelet PDE3A: The Role of the Unique 44 Amino Acid Insert. (2005) (0)
- Coenzyme Binding Site of NADP-Dependent Isocitrate Dehydrogenase (1988) (0)
- FROM THE STRUCTURE FUNCTION ANALYSIS OF THE CATALYTIC REGION OF HUMAN PLATELET PDE 3 A : A ROLE FOR THE UNIQUE 44 AMINO ACID INSERT (2006) (0)
- Evidence Supporting Model of Glutathione S‐Transferase pi/1‐Cysteine Peroxiredoxin Complex (2007) (0)
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