Robyn S. Klein
#160,876
Most Influential Person Now
American neuroimmunologist
Robyn S. Klein's AcademicInfluence.com Rankings
Robyn S. Kleinbiology Degrees
Biology
#13155
World Rank
#16684
Historical Rank
#2681
USA Rank
Immunology
#976
World Rank
#1000
Historical Rank
#102
USA Rank
Neuroscience
#2503
World Rank
#2569
Historical Rank
#301
USA Rank
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Biology
Robyn S. Klein's Degrees
- Doctorate Medicine University of California, San Francisco
- PhD Immunology University of California, San Francisco
Why Is Robyn S. Klein Influential?
(Suggest an Edit or Addition)According to Wikipedia, Robyn S. Klein is an American neuroimmunologist as well as the Vice Provost and Associate Dean for Graduate Education at Washington University in St. Louis Missouri. Klein is also a professor in the Departments of Medicine, Anatomy & Neurobiology, and Pathology & Immunology. Her research explores the pathogenesis of neuroinflammation in the central nervous system by probing how immune signalling molecules regulate blood brain barrier permeability. Klein is also a fervent advocate for gender equity in STEM, publishing mechanisms to improve gender equity in speakers at conferences, participating nationally on gender equity discussion panels, and through service as the president of the Academic Women’s Network at the Washington University School of Medicine.
Robyn S. Klein's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Zika Virus Infection during Pregnancy in Mice Causes Placental Damage and Fetal Demise (2016) (713)
- Resistance to Experimental Autoimmune Encephalomyelitis in Mice Lacking the Cc Chemokine Receptor (Ccr2) (2000) (632)
- A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors (2003) (612)
- A complement–microglial axis drives synapse loss during virus-induced memory impairment (2016) (434)
- Neuronal CXCL10 Directs CD8+ T-Cell Recruitment and Control of West Nile Virus Encephalitis (2005) (431)
- Ephrin-B Reverse Signaling Is Mediated by a Novel PDZ-RGS Protein and Selectively Inhibits G Protein–Coupled Chemoattraction (2001) (408)
- Prevalence, incidence, and type-specific persistence of human papillomavirus in human immunodeficiency virus (HIV)-positive and HIV-negative women. (2001) (339)
- Quantification of increased cellularity during inflammatory demyelination. (2011) (311)
- SDF-1 alpha induces chemotaxis and enhances Sonic hedgehog-induced proliferation of cerebellar granule cells. (2001) (277)
- CXCL12 Limits Inflammation by Localizing Mononuclear Infiltrates to the Perivascular Space during Experimental Autoimmune Encephalomyelitis1 (2006) (239)
- Detecting axon damage in spinal cord from a mouse model of multiple sclerosis (2006) (239)
- BDNF stimulates migration of cerebellar granule cells. (2002) (233)
- The blood-brain barrier, chemokines and multiple sclerosis. (2011) (224)
- Changes in B- and T-lymphocyte and chemokine levels with rituximab treatment in multiple sclerosis. (2010) (222)
- How COVID-19 Affects the Brain. (2021) (211)
- CXCR7 influences leukocyte entry into the CNS parenchyma by controlling abluminal CXCL12 abundance during autoimmunity (2011) (208)
- CXCR4 promotes differentiation of oligodendrocyte progenitors and remyelination (2010) (205)
- Chemokine receptor expression and signaling in macaque and human fetal neurons and astrocytes: implications for the neuropathogenesis of AIDS. (1999) (204)
- TREM2 regulates microglial cell activation in response to demyelination in vivo (2015) (188)
- Pathological expression of CXCL12 at the blood-brain barrier correlates with severity of multiple sclerosis. (2008) (184)
- COVID-19 neuropathology at Columbia University Irving Medical Center/New York Presbyterian Hospital (2021) (182)
- Interferon-λ restricts West Nile virus neuroinvasion by tightening the blood-brain barrier (2015) (175)
- CXCR3 Mediates Region-Specific Antiviral T Cell Trafficking within the Central Nervous System during West Nile Virus Encephalitis1 (2008) (172)
- Sex Drives Dimorphic Immune Responses to Viral Infections (2017) (170)
- Viral Pathogen-Associated Molecular Patterns Regulate Blood-Brain Barrier Integrity via Competing Innate Cytokine Signals (2014) (161)
- 2′-O Methylation of the Viral mRNA Cap by West Nile Virus Evades Ifit1-Dependent and -Independent Mechanisms of Host Restriction In Vivo (2012) (156)
- Trojan Horse Transit Contributes to Blood-Brain Barrier Crossing of a Eukaryotic Pathogen (2017) (144)
- Infectious immunity in the central nervous system and brain function (2017) (143)
- CXCR4 antagonism increases T cell trafficking in the central nervous system and improves survival from West Nile virus encephalitis (2008) (143)
- IFN-Inducible Protein 10/CXC Chemokine Ligand 10-Independent Induction of Experimental Autoimmune Encephalomyelitis1 (2004) (128)
- Astrocyte TNFR2 is required for CXCL12-mediated regulation of oligodendrocyte progenitor proliferation and differentiation within the adult CNS (2012) (123)
- Sex differences in cancer mechanisms (2020) (121)
- Immune and nervous system CXCL12 and CXCR4: parallel roles in patterning and plasticity. (2004) (119)
- T cells promote microglia-mediated synaptic elimination and cognitive dysfunction during recovery from neuropathogenic flaviviruses (2019) (113)
- Tumor Necrosis Factor Alpha Protects against Lethal West Nile Virus Infection by Promoting Trafficking of Mononuclear Leukocytes into the Central Nervous System (2008) (110)
- The Innate Immune Adaptor Molecule MyD88 Restricts West Nile Virus Replication and Spread in Neurons of the Central Nervous System (2010) (109)
- Chemokines in the balance: maintenance of homeostasis and protection at CNS barriers (2014) (108)
- Enhanced sphingosine-1-phosphate receptor 2 expression underlies female CNS autoimmunity susceptibility. (2014) (107)
- The TAM receptor Mertk protects against neuroinvasive viral infection by maintaining blood-brain barrier integrity (2015) (106)
- Protective and Pathological Immunity during Central Nervous System Infections (2017) (102)
- Immortalized human cerebral microvascular endothelial cells maintain the properties of primary cells in an in vitro model of immune migration across the blood brain barrier (2013) (97)
- Regional astrocyte IFN signaling restricts pathogenesis during neurotropic viral infection (2017) (95)
- IL-1R Signaling within the Central Nervous System Regulates CXCL12 Expression at the Blood-Brain Barrier and Disease Severity during Experimental Autoimmune Encephalomyelitis1 (2009) (90)
- CD40-CD40 Ligand Interactions Promote Trafficking of CD8+ T Cells into the Brain and Protection against West Nile Virus Encephalitis (2007) (88)
- West Nile virus: crossing the blood-brain barrier (2004) (87)
- Targeting monocyte recruitment in CNS autoimmune disease. (2002) (86)
- Astrocytes decrease adult neurogenesis during virus-induced memory dysfunction via interleukin-1 (2017) (81)
- The Olfactory Bulb: An Immunosensory Effector Organ during Neurotropic Viral Infections. (2016) (80)
- IL-1R1 is required for dendritic cell–mediated T cell reactivation within the CNS during West Nile virus encephalitis (2013) (79)
- Neuroinflammation During RNA Viral Infections. (2019) (78)
- Mediators of oligodendrocyte differentiation during remyelination (2011) (76)
- Speaking out about gender imbalance in invited speakers improves diversity (2017) (73)
- Viral Encephalitis and Neurologic Diseases: Focus on Astrocytes. (2018) (72)
- Bone Marrow Transplantation Augments the Effect of Brain- and Spinal Cord-Directed Adeno-Associated Virus 2/5 Gene Therapy by Altering Inflammation in the Murine Model of Globoid-Cell Leukodystrophy (2011) (71)
- A single intranasal or intramuscular immunization with chimpanzee adenovirus vectored SARS-CoV-2 vaccine protects against pneumonia in hamsters (2020) (69)
- Encephalitic Arboviruses: Emergence, Clinical Presentation, and Neuropathogenesis (2016) (68)
- Mycobacterium tuberculosis carrying a rifampicin drug resistance mutation reprograms macrophage metabolism through cell wall lipid changes (2018) (61)
- CSF1R antagonism limits local restimulation of antiviral CD8+ T cells during viral encephalitis (2019) (61)
- An international collaborative study of the effects of coinfection with human T-lymphotropic virus type II on human immunodeficiency virus type 1 disease progression in injection drug users. (1996) (58)
- Plasmodium falciparum Histidine-Rich Protein II Compromises Brain Endothelial Barriers and May Promote Cerebral Malaria Pathogenesis (2016) (57)
- SDF-1 α induces chemotaxis and enhances Sonic hedgehog-induced proliferation of cerebellar granule cells (2001) (55)
- Mechanisms of Pathogen Invasion into the Central Nervous System (2019) (52)
- Targeting CXCR7/ACKR3 as a therapeutic strategy to promote remyelination in the adult central nervous system (2014) (51)
- IL-1R1 Signaling Regulates CXCL12-Mediated T Cell Localization and Fate within the Central Nervous System during West Nile Virus Encephalitis (2014) (50)
- A tumor necrosis factor receptor 1-dependent conversation between central nervous system-specific T cells and the central nervous system is required for inflammatory infiltration of the spinal cord. (2006) (49)
- Virus entry and replication in the brain precedes blood-brain barrier disruption during intranasal alphavirus infection (2017) (48)
- TNF-α-dependent regulation of CXCR3 expression modulates neuronal survival during West Nile virus encephalitis (2010) (46)
- A single intranasal or intramuscular immunization with chimpanzee adenovirus-vectored SARS-CoV-2 vaccine protects against pneumonia in hamsters (2021) (46)
- Regulation of neuroinflammation: The role of CXCL10 in lymphocyte infiltration during autoimmune encephalomyelitis (2004) (45)
- Immunological headgear: antiviral immune responses protect against neuroinvasive West Nile virus. (2008) (44)
- CXCR7 antagonism prevents axonal injury during experimental autoimmune encephalomyelitis as revealed by in vivo axial diffusivity (2011) (41)
- Heterogeneous expression of car☐ypeptidase E and proenkephalin mRNAs by cultured astrocytes (1992) (41)
- Rituximab combination therapy in relapsing multiple sclerosis (2012) (41)
- Preconditioning-induced CXCL12 upregulation minimizes leukocyte infiltration after stroke in ischemia-tolerant mice (2017) (37)
- A moving target: the multiple roles of CCR5 in infectious diseases. (2008) (34)
- A genetic basis for human susceptibility to West Nile virus. (2006) (33)
- Therapeutic enhancement of blood–brain and blood–tumor barriers permeability by laser interstitial thermal therapy (2020) (32)
- CCR5 limits cortical viral loads during West Nile virus infection of the central nervous system (2015) (30)
- Interferon-l restricts West Nile virus neuroinvasion by tightening the blood-brain barrier (2015) (30)
- Secretion of Carboxypeptidase E from Cultured Astrocytes and from AtT‐20 Cells, a Neuroendocrine Cell Line: Implications for Neuropeptide Biosynthesis (1992) (29)
- Region-specific regulation of inflammation and pathogenesis in experimental autoimmune encephalomyelitis (2006) (28)
- Astrocyte‐T cell crosstalk regulates region‐specific neuroinflammation (2020) (27)
- COVID-19 induces neuroinflammation and loss of hippocampal neurogenesis (2021) (25)
- Peli1 facilitates virus replication and promotes neuroinflammation during West Nile virus infection (2018) (24)
- Encephalitic Alphaviruses Exploit Caveola-Mediated Transcytosis at the Blood-Brain Barrier for Central Nervous System Entry (2020) (24)
- Knocking on Closed Doors: Host Interferons Dynamically Regulate Blood-Brain Barrier Function during Viral Infections of the Central Nervous System (2015) (24)
- CCR2 Signaling Restricts SARS-CoV-2 Infection (2021) (24)
- How COVID-19 shaped mental health: from infection to pandemic effects (2022) (22)
- COVID-19 induces CNS cytokine expression and loss of hippocampal neurogenesis (2022) (19)
- Congenitally Acquired Persistent Lymphocytic Choriomeningitis Viral Infection Reduces Neuronal Progenitor Pools in the Adult Hippocampus and Subventricular Zone (2014) (19)
- Disruption of the Blood-Brain Barrier During Neuroinflammatory and Neuroinfectious Diseases (2019) (19)
- Cultured astrocytes express mRNA for peptidylglycine-α-amidating monooxygenase, a neuropeptide processing enzyme (1992) (18)
- MicroRNA signature of central nervous system‐infiltrating dendritic cells in an animal model of multiple sclerosis (2018) (18)
- Molecular targets for disrupting leukocyte trafficking during multiple sclerosis (2007) (18)
- Plasmodium falciparum histidine-rich protein II causes vascular leakage and exacerbates experimental cerebral malaria in mice (2017) (17)
- Update on T cells in the virally infected brain: friends and foes (2020) (15)
- Viral interactions with the blood-brain barrier: old dog, new tricks (2016) (15)
- A potent and selective C-11 labeled PET tracer for imaging sphingosine-1-phosphate receptor 2 in the CNS demonstrates sexually dimorphic expression. (2015) (13)
- Differential In Vitro Infection of Neural Cells by Astroviruses (2019) (12)
- Astrocytes decrease adult neurogenesis during virus-induced memory dysfunction via IL-1 (2018) (11)
- Chemokines Referee Inflammation within the Central Nervous System during Infection and Disease (2014) (11)
- Neuroprotective versus Neuroinflammatory Roles of Complement: From Development to Disease (2020) (11)
- Oropharyngeal Candida colonization and human immunodeficiency virus type 1 infection. (2000) (10)
- Neuroinflammation and COVID-19 (2022) (9)
- CXCL9 compensates for the absence of CXCL10 during recurrent Herpetic stromal keratitis. (2017) (9)
- IL-1 reprogramming of adult neural stem cells limits neurocognitive recovery after viral encephalitis by maintaining a proinflammatory state (2021) (9)
- CCR2-dependent monocyte-derived cells restrict SARS-CoV-2 infection (2021) (8)
- Molecular and Immunocytochemical Studies of Neurofibromas and Related Cell Types a (1986) (8)
- Regulation of carboxypeptidase E (enkephalin convertase). (1991) (8)
- Central Nervous System Pathology Progresses Independently of KC and CXCR2 in Globoid-Cell Leukodystrophy (2013) (7)
- Single-cell RNA transcriptome analysis of CNS immune cells reveals CXCL16/CXCR6 as maintenance factors for tissue-resident T cells that drive synapse elimination (2022) (7)
- Viruses have multiple paths to central nervous system pathology (2018) (7)
- The evolution of Candida species and fluconazole susceptibility among oral and vaginal isolates recovered from human immunodeficiency virus (HIV)-seropositive and at-risk HIV-seronegative women. (2001) (7)
- Differential Effects of a Phorbol Ester on Carboxypeptidase E in Cultured Astrocytes and AtT‐20 Cells, a Neuroendocrine Cell Line (1993) (6)
- Effect of pregnancy on the risk of developing active tuberculosis. (1997) (6)
- Decreased antiviral immune response within the central nervous system of aged mice is associated with increased lethality of West Nile virus encephalitis (2021) (6)
- Design and synthesis of pyrazolopyridine derivatives as sphingosine 1-phosphate receptor 2 ligands. (2017) (5)
- Infection and inflammation: New perspectives on Alzheimer's disease (2022) (5)
- Design, synthesis, and in vitro bioactivity evaluation of fluorine-containing analogues for sphingosine-1-phosphate 2 receptor. (2019) (5)
- A Deletion in the Chemokine Receptor 5 (CCR5) Gene Is Associated with Tickbome Encephalitis. Commentary (2008) (4)
- Peli 1 facilitates virus replication and promotes neuroinflammation during West Nile virus 1 infection 2 (2018) (4)
- Mechanisms of coronavirus infectious disease 2019-related neurologic diseases (2022) (4)
- Encephalitic Arboviruses of Africa: Emergence, Clinical Presentation and Neuropathogenesis (2021) (3)
- Chemokines and Viral Infections of the CNS (2011) (3)
- Levels of Circulating NS1 Impact West Nile Virus Spread to the Brain (2021) (3)
- Astrocyte interleukin-3 preps microglia. (2021) (3)
- On Complement, Memory, and Microglia. (2020) (3)
- Chicago medical library journal club. (1976) (3)
- Type III Interferons: Emerging Roles in Autoimmunity (2021) (3)
- A new era in neuroimmunology (2021) (2)
- An In Vitro Brain Endothelial Model for Studies of Cryptococcal Transmigration into the Central Nervous System (2019) (2)
- Dual Blades: The Role of Musashi 1 in Zika Replication and Microcephaly. (2017) (2)
- Publisher Correction: Mycobacterium tuberculosis carrying a rifampicin drug resistance mutation reprograms macrophage metabolism through cell wall lipid changes (2018) (2)
- Comment: Assessing humoral immunocompetence after alemtuzumab treatment in MS (2013) (2)
- Laser Therapy Enhances Blood-Brain Barrier and Blood-Tumor Barrier Permeability in a Mouse Model of Glioblastoma (2019) (2)
- CSF1R antagonism limits local restimulation of antiviral CD8+ T cells during viral encephalitis (2019) (2)
- IFN{gamma} regulates CXCL12 expression and cell trafficking during WNV infection (2011) (1)
- Encephalomyelitisduring Experimental Autoimmune Blood-Brain Barrier and Disease Severity System Regulates CXCL12 Expression at the IL-1R Signaling within the Central Nervous (2009) (1)
- PET Study of Sphingosine-1-phosphate Receptor 1 Expression in Response to S. aureus Infection (2021) (1)
- Targeting interferon-λ signaling promotes recovery from central nervous system autoimmunity (2021) (1)
- EncephalomyelitisSpace during Experimental Autoimmune Mononuclear Infiltrates to the Perivascular CXCL12 Limits Inflammation by Localizing (2006) (1)
- T cells promote microglia-mediated synaptic elimination and cognitive dysfunction during recovery from neuropathogenic flaviviruses (2019) (1)
- The multitaskers of the brain: Glial responses to viral infections and associated post‐infectious neurologic sequelae (2022) (1)
- TNF-α promotes CD4 T cell infiltration of the central nervous system (CNS) by altering the polarity of CXCL12 expression at the blood-brain barrier (BBB) (96.18) (2007) (0)
- Chemokines and Clearance of West Nile Virus Infection (2009) (0)
- Publisher Correction: Mycobacterium tuberculosis carrying a rifampicin drug resistance mutation reprograms macrophage metabolism through cell wall lipid changes (2018) (0)
- Mycobacterium tuberculosis carrying a rifampicin drug resistance mutation reprograms macrophage metabolism through cell wall lipid changes (2018) (0)
- Central nervous system pathology progresses independently of KC and CXCR 2 in globoid-cell leukodystrophy (2019) (0)
- Microglia at the scene of the crime: what their transcriptomics reveal about brain health. (2023) (0)
- Zika Virus Infection during Pregnancy in Mice Causes Placental Damage and Fetal (2016) (0)
- Encephalitic Arboviruses: Emergence, Clinical Presentation, and Neuropathogenesis (2016) (0)
- Fragile-like regulatory T cells modulate opioid withdrawal in humans and mice. (2023) (0)
- IFNγ regulates CXCL12 expression and cell trafficking during WNV infection (105.39) (2011) (0)
- Pathogen recognition regulates blood–brain barrier integrity and protects against West Nile virus entry via competing innate cytokine signals (2014) (0)
- This information is current as during West Nile Virus Encephalitis Fate within the Central Nervous System CXCL12-Mediated T Cell Localization and IL-1R1 Signaling Regulates (2014) (0)
- Neuronal CXCL10 Directs CD8 (cid:1) T-Cell Recruitment and Control of West Nile Virus Encephalitis (2005) (0)
- Advisory Board and Contents (2020) (0)
- Sexually dimorphic expression of S1PR2 as candidate for susceptibility to CNS autoimmunity (2012) (0)
- Single-cell RNA transcriptome analysis reveals CXCL16/CXCR6 as maintenance factors for CNS tissue resident T cells that drive synapse elimination during viral recovery (2021) (0)
- EXTH-35. LASER INTERSTITIAL THERMAL THERAPY INCREASES BLOOD-BRAIN BARRIER AND BLOOD-TUMOR BARRIER PERMEABILITY IN A MOUSE MODEL OF GLIOBLASTOMA (2019) (0)
- Encephalitic alphaviruses exploit caveolae-mediated transcytosis at the blood-brain barrier for CNS entry (2019) (0)
- HIV Coreceptors and Their Roles in Leukocyte Trafficking During Neuroinflammatory Diseases (2009) (0)
- Erratum for Vanderheiden et al., “CCR2 Signaling Restricts SARS-CoV-2 Infection” (2022) (0)
- Targeting IFN-λ Signaling Promotes Recovery from Central Nervous System Autoimmunity (2022) (0)
- Sex differences in cancer mechanisms (2020) (0)
- Corrigendum to: “IL-1 reprogramming of adult neural stem cells limits neurocognitive recovery after viral encephalitis by maintaining a proinflammatory state” [Brain Behav. Immun. 99 (2022) 383–396] (2022) (0)
- DEVELOPMENT OF FLUORESCENT-BASED QUANTIFICATION METHOD TO DETERMINE THE AMOUNT OF GLYCANS IMMOBILIZED ON A SURFACE (2011) (0)
- Advisory Board and Contents (2021) (0)
- CHAPTER 10 – Medical Botany (2007) (0)
- TNF-{alpha} promotes CD4 T cell infiltration of the central nervous system (CNS) by altering the polarity of CXCL12 expression at the blood-brain barrier (BBB) (2007) (0)
- Meningeal MAIT cells maintain meningeal and brain function. (2022) (0)
- Synthesis and characterization of [125I]TZ6544, a promising radioligand for investigating sphingosine-1-phosphate receptor 2. (2020) (0)
- Promoting endogenous protective mechanisms at the blood-brain barrier to reduce neurovascular inflammatory injury following stroke (2010) (0)
- 8 Chemokines and Viral Infections of the CNS (2017) (0)
- Encephalomyelitis Experimental Autoimmune Ligand 10-Independent Induction of IFN-Inducible Protein 10 / CXC Chemokine and (2003) (0)
- Regulation and Loss of Neuroprotection in Viral and Autoimmune Diseases of the Central Nervous System (2021) (0)
- CD40-CD40 Ligand Interactions Promote Trafficking of CD8 (cid:1) T Cells into the Brain and Protection against West Nile Virus Encephalitis (cid:1) (2007) (0)
- Neuropathogenesis of AIDS Neurons and Astrocytes: Implications for the Signaling in Macaque and Human Fetal Chemokine Receptor Expression and (1999) (0)
- CCR5 limits cortical viral loads during West Nile virus infection of the central nervous system (2015) (0)
- CXCR7 antagonism prevents leukocyte trafficking into the central nervous system and treats ongoing disease during experimental autoimmune encephalomyelitis. (96.5) (2010) (0)
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Robyn S. Klein is affiliated with the following schools:
