Roderick Bronson

Q: What Schools Are Affiliated With Roderick Bronson

Roderick Bronson is affiliated with the following schools: Tufts University, University of Strasbourg, KU Leuven, Kumamoto University, Osaka University, Kyoto University, University of Bergen, Tohoku University, Massachusetts Institute of Technology, Stanford University, University of Connecticut, University of Würzburg, University of Manchester, Harvard University

Roderick Bronson's AcademicInfluence.com Rankings

Roderick Bronson

Engineering

#1817

World Rank

#2594

Historical Rank

Electrical Engineering

#259

World Rank

#297

Historical Rank

engineering Degrees

Roderick Bronson

Computer Science

#2769

World Rank

#2897

Historical Rank

Computational Linguistics

#52

World Rank

#54

Historical Rank

Machine Learning

#201

World Rank

#204

Historical Rank

Artificial Intelligence

#347

World Rank

#354

Historical Rank

computer-science Degrees

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Engineering
Computer Science

Roderick Bronson's Degrees

Masters Electrical Engineering Stanford University

Why Is Roderick Bronson Influential?

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According to Wikipedia, Roderick T. Bronson, D.V.M. is an American pathologist and the director of the Rodent Pathology Core at Harvard Medical School. Dr. Bronson has authored or co-authored more than 400 scientific articles and has been recognized by I.S.I. Thompson as a highly cited author.

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Roderick Bronson's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Targeted Disruption of Cbfa1 Results in a Complete Lack of Bone Formation owing to Maturational Arrest of Osteoblasts (1997) (4305)
Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein (2002) (2351)
p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development (1999) (2296)
Tumor spectrum analysis in p53-mutant mice (1994) (2115)
Identification of Bronchioalveolar Stem Cells in Normal Lung and Lung Cancer (2005) (2101)
Effects of an Rb mutation in the mouse (1992) (1877)
Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. (2001) (1795)
Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice. (1998) (1726)
Targeted Deletion Reveals Essential and Overlapping Functions of the miR-17∼92 Family of miRNA Clusters (2008) (1578)
Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB (1995) (1414)
Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene (1991) (1327)
Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6 (2006) (1229)
Mutant p53 Gain of Function in Two Mouse Models of Li-Fraumeni Syndrome (2004) (1220)
Somatic activation of the K-ras oncogene causes early onset lung cancer in mice (2001) (1151)
Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene. (1994) (1117)
Mammalian Sir2 Homolog SIRT3 Regulates Global Mitochondrial Lysine Acetylation (2007) (1116)
Physiological consequences of loss of plasminogen activator gene function in mice (1994) (1107)
Cyclin D1 provides a link between development and oncogenesis in the retina and breast (1995) (1092)
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice (2003) (1088)
p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours (2000) (1065)
Gene Dosage–Dependent Embryonic Development and Proliferation Defects in Mice Lacking the Transcriptional Integrator p300 (1998) (1037)
Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells (2005) (998)
Skeletal and CNS Defects in Presenilin-1-Deficient Mice (1997) (978)
LKB1 modulates lung cancer differentiation and metastasis (2007) (975)
Telomere dysfunction induces metabolic and mitochondrial compromise (2011) (960)
Targeted ablation of the vitamin D receptor: an animal model of vitamin D-dependent rickets type II with alopecia. (1997) (892)
Involvement of granulocyte-macrophage colony-stimulating factor in pulmonary homeostasis. (1994) (890)
Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma. (1996) (888)
A mouse model for Down syndrome exhibits learning and behaviour deficits (1995) (875)
Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects. (2004) (807)
Tumor Induction and Tissue Atrophy in Mice Lacking E2F-1 (1996) (797)
Phenotype of mice lacking functional Deleted in colorectal cancer (Dec) gene (1997) (787)
Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression (2003) (753)
Mice Lacking p35, a Neuronal Specific Activator of Cdk5, Display Cortical Lamination Defects, Seizures, and Adult Lethality (1997) (752)
Tumour predisposition in mice heterozygous for a targeted mutation in Nf1 (1994) (747)
Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B. (1995) (746)
Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis (1996) (733)
Mouse Development and Cell Proliferation in the Absence of D-Cyclins (2004) (691)
Cyclin E Ablation in the Mouse (2003) (676)
A Critical Role for DNA End-Joining Proteins in Both Lymphogenesis and Neurogenesis (1998) (674)
Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of mice. (2011) (660)
CRISPR-mediated direct mutation of cancer genes in the mouse liver (2014) (636)
Herpes simplex virus 1 interaction with Toll-like receptor 2 contributes to lethal encephalitis. (2004) (632)
A subset of p53-deficient embryos exhibit exencephaly (1995) (620)
The harlequin mouse mutation downregulates apoptosis-inducing factor (2002) (602)
K-ras is an essential gene in the mouse with partial functional overlap with N-ras. (1997) (574)
Mosaic Analysis with Double Markers Reveals Tumor Cell of Origin in Glioma (2011) (573)
Mice Deficient in Cellular Glutathione Peroxidase Develop Normally and Show No Increased Sensitivity to Hyperoxia* (1997) (572)
Tumor predisposition in mice mutant for p63 and p73: evidence for broader tumor suppressor functions for the p53 family. (2005) (548)
Efficient and Rapid Induction of a Chronic Myelogenous Leukemia-Like Myeloproliferative Disease in Mice Receiving P210 bcr/abl-Transduced Bone Marrow (1998) (548)
Genome sequencing reveals insights into physiology and longevity of the naked mole rat (2011) (511)
Millisecond-Timescale Optical Control of Neural Dynamics in the Nonhuman Primate Brain (2009) (498)
The differential effects of mutant p53 alleles on advanced murine lung cancer. (2005) (496)
Shared role of the pRB-related p130 and p107 proteins in limb development. (1996) (470)
Constitutive NF-kappa B activation, enhanced granulopoiesis, and neonatal lethality in I kappa B alpha-deficient mice. (1995) (469)
Mouse models of tumor development in neurofibromatosis type 1. (1999) (466)
Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP. (2000) (445)
The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies. (2006) (440)
Many Ribosomal Protein Genes Are Cancer Genes in Zebrafish (2004) (436)
Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration (2003) (426)
Essential Roles for the Abl and Arg Tyrosine Kinases in Neurulation (1998) (417)
An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection (2006) (417)
Mouse model of Noonan syndrome reveals cell type– and gene dosage–dependent effects of Ptpn11 mutation (2004) (415)
p63 protects the female germ line during meiotic arrest (2006) (412)
Suppression of Lung Adenocarcinoma Progression by Nkx2-1 (2011) (408)
Absence of fetal liver hematopoiesis in mice deficient in transcriptional coactivator core binding factor beta. (1996) (405)
Cooperative tumorigenic effects of germline mutations in Rb and p53 (1994) (405)
Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects (2000) (401)
p35 and p39 Are Essential for Cyclin-Dependent Kinase 5 Function during Neurodevelopment (2001) (394)
High tumor incidence and activation of the PI3K/AKT pathway in transgenic mice define AIB1 as an oncogene. (2004) (394)
Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors. (1998) (392)
An oncogene–tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-κB (2010) (392)
Intrinsic requirement for zinc finger transcription factor Gfi-1 in neutrophil differentiation. (2003) (382)
Keap1 loss promotes Kras-driven lung cancer and results in a dependence on glutaminolysis (2017) (376)
Retinoid signaling and activator protein-1 expression in ferrets given beta-carotene supplements and exposed to tobacco smoke. (1999) (375)
Targeted disruption of p107: functional overlap between p107 and Rb. (1996) (367)
Mice lacking the myotonic dystrophy protein kinase develop a late onset progressive myopathy (1996) (365)
Rescue of Cyclin D1 Deficiency by Knockin Cyclin E (1999) (364)
Class IIa HDAC inhibition reduces breast tumours and metastases through anti-tumour macrophages (2017) (362)
Reduced Fertility in Female Mice Lacking Copper-Zinc Superoxide Dismutase* (1998) (352)
Plasminogen activator inhibitor-1 gene-deficient mice. I. Generation by homologous recombination and characterization. (1993) (351)
Loss of Pin1 function in the mouse causes phenotypes resembling cyclin D1-null phenotypes (2002) (347)
N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility (2001) (343)
Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow. (1998) (342)
A Defect in Nurturing in Mice Lacking the Immediate Early Gene fosB (1996) (335)
Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/−) mice (1998) (334)
Perp Is a p63-Regulated Gene Essential for Epithelial Integrity (2005) (323)
Extensive contribution of Rb‐deficient cells to adult chimeric mice with limited histopathological consequences. (1994) (323)
Classification of Proliferative Pulmonary Lesions of the Mouse (2004) (321)
N-myc can functionally replace c-myc in murine development, cellular growth, and differentiation. (2000) (320)
Rapid modeling of cooperating genetic events in cancer through somatic genome editing (2014) (314)
Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85α (2000) (313)
Functional screening of 2 Mb of human chromosome 21q22.2 in transgenic mice implicates minibrain in learning defects associated with Down syndrome (1997) (311)
PARP Inhibition Elicits STING-Dependent Antitumor Immunity in Brca1-Deficient Ovarian Cancer (2018) (305)
Neuronal loss and brain atrophy in mice lacking cathepsins B and L (2002) (304)
Development of mice expressing a single D-type cyclin. (2002) (304)
Mice mutant for Egfr and Shp2 have defective cardiac semilunar valvulogenesis (2000) (303)
Regulatory T Cells in Tumor-Associated Tertiary Lymphoid Structures Suppress Anti-tumor T Cell Responses. (2015) (300)
Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition (2009) (300)
APC-dependent suppression of colon carcinogenesis by PPARγ (2002) (298)
Delayed occurrence of fatal neoplastic diseases in ames dwarf mice: correlation to extended longevity. (2003) (293)
A spatially and temporally restricted mouse model of soft tissue sarcoma (2007) (292)
Segmental trisomy as a mouse model for Down syndrome. (1993) (291)
The mouse pudgy mutation disrupts Delta homologue Dll3 and initiation of early somite boundaries (1998) (291)
A novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog pathway. (2006) (286)
New Alström syndrome phenotypes based on the evaluation of 182 cases. (2005) (281)
Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKClambda/zeta. (2006) (278)
Mediator Kinase Inhibition Further Activates Super-Enhancer Associated Genes in AML (2015) (274)
Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure. (2008) (273)
Sodium/Hydrogen Exchanger Gene Defect in Slow-Wave Epilepsy Mutant Mice (1997) (271)
Essential Role of Endothelial Notch1 in Angiogenesis (2005) (268)
Parathyroid Hormone Directs Bone Marrow Mesenchymal Cell Fate. (2017) (261)
Loss of NFAT5 results in renal atrophy and lack of tonicity-responsive gene expression. (2004) (259)
mTORC1 promotes survival through translational control of Mcl-1 (2008) (259)
Pathologic Characterization of Brown Norway, Brown Norway × Fischer 344, and Fischer 344 × Brown Norway Rats With Relation to Age (1996) (258)
Stage-specific sensitivity to p53 restoration during lung cancer progression (2010) (254)
COMPROMISED CDK1 ACTIVITY SENSITIZES BRCA-PROFICIENT CANCERS TO PARP INHIBITION (2011) (253)
Epidermal growth factor receptor variant III mutations in lung tumorigenesis and sensitivity to tyrosine kinase inhibitors (2006) (253)
Metastatic osteosarcoma induced by inactivation of Rb and p53 in the osteoblast lineage (2008) (252)
Donor lymphocyte infusions mediate superior graft-versus-leukemia effects in mixed compared to fully allogeneic chimeras: a critical role for host antigen-presenting cells. (2002) (248)
K-ras activation generates an inflammatory response in lung tumors (2006) (244)
TCR-inducible PLZF transcription factor required for innate phenotype of a subset of γδ T cells with restricted TCR diversity (2009) (242)
UHRF1 overexpression drives DNA hypomethylation and hepatocellular carcinoma. (2014) (242)
Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome-associated PTPN11 mutation. (2011) (241)
Exploiting cancer cell vulnerabilities to develop a combination therapy for ras-driven tumors. (2011) (237)
Selective ablation of αv integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death (2004) (237)
Th1 and Th2 mediate acute graft-versus-host disease, each with distinct end-organ targets. (2000) (237)
Cancer-Associated PTEN Mutants Act in a Dominant-Negative Manner to Suppress PTEN Protein Function (2014) (231)
Distinct roles for CREB-binding protein and p300 in hematopoietic stem cell self-renewal (2002) (231)
The adhesion signaling molecule p190 RhoGAP is required for morphogenetic processes in neural development. (2000) (230)
Ena/VASP Is Required for Neuritogenesis in the Developing Cortex (2007) (230)
VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P2 in yeast and mouse (2008) (227)
Genome analysis reveals insights into physiology and longevity of the Brandt’s bat Myotis brandtii (2013) (226)
Engineered bacteria can function in the mammalian gut long-term as live diagnostics of inflammation (2017) (226)
E2F4 is essential for normal erythrocyte maturation and neonatal viability. (2000) (222)
Failure of lymphopoiesis after adoptive transfer of NF-kappaB-deficient fetal liver cells. (1997) (220)
Primary hyperparathyroidism caused by parathyroid-targeted overexpression of cyclin D1 in transgenic mice. (2001) (217)
Tumor formation and inactivation of RIZ1, an Rb-binding member of a nuclear protein-methyltransferase superfamily. (2001) (216)
Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis (2009) (214)
p53 Controls Radiation-Induced Gastrointestinal Syndrome in Mice Independent of Apoptosis (2009) (213)
Elucidating distinct roles for NF1 in melanomagenesis. (2013) (212)
p25/Cyclin-Dependent Kinase 5 Induces Production and Intraneuronal Accumulation of Amyloid β In Vivo (2006) (212)
Mutations in a novel CLN6-encoded transmembrane protein cause variant neuronal ceroid lipofuscinosis in man and mouse. (2002) (210)
A specific, nonproliferative role for E2F-5 in choroid plexus function revealed by gene targeting. (1998) (204)
Small RNA combination therapy for lung cancer (2014) (203)
Ulcerative colitis and autoimmunity induced by loss of myeloid αv integrins (2007) (201)
Efficient generation and mapping of recessive developmental mutations using ENU mutagenesis (2002) (199)
Stargazer: a new neurological mutant on chromosome 15 in the mouse with prolonged cortical seizures (1990) (199)
Prevention of tissue injury and postsurgical adhesions by precoating tissues with hyaluronic acid solutions. (1995) (196)
Development of a mouse model for sporadic and metastatic colon tumors and its use in assessing drug treatment (2010) (196)
Endogenous T cell responses to antigens expressed in lung adenocarcinomas delay malignant tumor progression. (2011) (196)
WAVE2 deficiency reveals distinct roles in embryogenesis and Rac‐mediated actin‐based motility (2003) (195)
An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer (2018) (195)
An inflammatory checkpoint regulates recruitment of graft-versus-host reactive T cells to peripheral tissues (2006) (194)
Ventricular septal defect and cardiomyopathy in mice lacking the transcription factor CHF1/Hey2 (2002) (191)
Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer. (2010) (191)
Adenomatous Polyposis Coli (APC) Is Required for Normal Development of Skin and Thymus (2006) (189)
Cln3(Deltaex7/8) knock-in mice with the common JNCL mutation exhibit progressive neurologic disease that begins before birth. (2002) (187)
TAZ Promotes PC2 Degradation through a SCFβ-Trcp E3 Ligase Complex (2007) (186)
Mutations in the p53 and SCID genes cooperate in tumorigenesis. (1996) (186)
HER2YVMA drives rapid development of adenosquamous lung tumors in mice that are sensitive to BIBW2992 and rapamycin combination therapy (2009) (185)
Variation in age at death of dogs of different sexes and breeds. (1982) (184)
Mutations in BRAF and KRAS converge on activation of the mitogen-activated protein kinase pathway in lung cancer mouse models. (2007) (184)
Proapoptotic BID is required for myeloid homeostasis and tumor suppression. (2003) (182)
Disruption of muscle membrane and phenotype divergence in two novel mouse models of dysferlin deficiency. (2004) (181)
Slug, a highly conserved zinc finger transcriptional repressor, protects hematopoietic progenitor cells from radiation-induced apoptosis in vivo. (2002) (179)
The vibrator Mutation Causes Neurodegeneration via Reduced Expression of PITPα: Positional Complementation Cloning and Extragenic Suppression (1997) (179)
Mutations in the WRN Gene in Mice Accelerate Mortality in a p53-Null Background (2000) (176)
Skeletal muscle deformity and neuronal disorder in Trio exchange factor-deficient mouse embryos. (2000) (176)
Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity (2010) (174)
Targeted disruption of NBS1 reveals its roles in mouse development and DNA repair (2002) (174)
The development of a model for the homing of multiple myeloma cells to human bone marrow. (1997) (170)
Alms1-disrupted mice recapitulate human Alström syndrome. (2005) (168)
Telomere dysfunction induces metabolic and mitochondrial compromise (2011) (168)
Cancer stem cells are enriched in the side population cells in a mouse model of glioma. (2008) (167)
ETV1 directs androgen metabolism and confers aggressive prostate cancer in targeted mice and patients. (2013) (166)
Regulable neural progenitor-specific Tsc1 loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complex (2011) (162)
Chronic Activation of mTOR Complex 1 Is Sufficient to Cause Hepatocellular Carcinoma in Mice (2012) (162)
p21 Is a Critical CDK2 Regulator Essential for Proliferation Control in Rb-deficient Cells (1998) (162)
Elevated neuronal expression of CD200 protects Wlds mice from inflammation-mediated neurodegeneration. (2007) (160)
Deletion of the p27Kip1 gene restores normal development in cyclin D1-deficient mice. (2001) (159)
Motor neuron degeneration of mice is a model of neuronal ceroid lipofuscinosis (Batten's disease) (1993) (158)
Interleukin-15/interleukin-15R alpha complexes promote destruction of established tumors by reviving tumor-resident CD8+ T cells. (2008) (157)
Tumor-secreted vascular endothelial growth factor-C is necessary for prostate cancer lymphangiogenesis, but lymphangiogenesis is unnecessary for lymph node metastasis. (2005) (157)
Conditional Mutation of Rb Causes Cell Cycle Defects without Apoptosis in the Central Nervous System (2003) (156)
PAK4 Kinase Is Essential for Embryonic Viability and for Proper Neuronal Development (2003) (156)
Effects of physiological versus pharmacological beta-carotene supplementation on cell proliferation and histopathological changes in the lungs of cigarette smoke-exposed ferrets. (2000) (155)
Persistent activation of microglia is associated with neuronal dysfunction of callosal projecting pathways and multiple sclerosis-like lesions in relapsing--remitting experimental autoimmune encephalomyelitis. (2007) (153)
Disruption of the murine gene encoding phosphatidylethanolamine N-methyltransferase. (1997) (151)
Impaired thymic tolerance to α-myosin directs autoimmunity to the heart in mice and humans. (2011) (151)
Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance. (2018) (151)
Adaptations to a subterranean environment and longevity revealed by the analysis of mole rat genomes. (2014) (150)
A Feedback Loop Involving the Phd3 Prolyl Hydroxylase Tunes the Mammalian Hypoxic Response In Vivo (2009) (148)
Nuclear factor I/B is an oncogene in small cell lung cancer. (2011) (147)
Absence of the CD44 gene prevents sarcoma metastasis. (2002) (147)
Cloning and Variation of Ground State Intestinal Stem Cells (2015) (147)
Gastric Hyperplasia in Mice Lacking the Putative Cdc42 Effector IQGAP1 (2000) (146)
The Notch coactivator, MAML1, functions as a novel coactivator for MEF2C-mediated transcription and is required for normal myogenesis. (2006) (146)
Inflammation and Disintegration of Intestinal Villi in an Experimental Model for Vibrio parahaemolyticus-Induced Diarrhea (2012) (143)
Ulcerative colitis and autoimmunity induced by loss of myeloid alphav integrins. (2007) (143)
Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1 (2011) (143)
Endothelial α5 and αv integrins cooperate in remodeling of the vasculature during development (2010) (143)
MDA5 and MAVS Mediate Type I Interferon Responses to Coxsackie B Virus (2009) (142)
Graft-versus-host disease can be separated from graft-versus-lymphoma effects by control of lymphocyte trafficking with FTY720. (2003) (141)
Defective apoptosis and B‐cell lymphomas in mice with p53 point mutation at Ser 23 (2004) (139)
Neuronal ceroid lipofuscinosis (nclf), a new disorder of the mouse linked to chromosome 9. (1998) (139)
Prevention of type 1 diabetes in mice by tolerogenic vaccination with a strong agonist insulin mimetope (2011) (138)
Oncogenic KRAS supports pancreatic cancer through regulation of nucleotide synthesis (2018) (137)
Activation of paternally expressed genes and perinatal death caused by deletion of the Gtl2 gene (2010) (136)
ETV6-NTRK3 fusion oncogene initiates breast cancer from committed mammary progenitors via activation of AP1 complex. (2007) (136)
The impact of reduced frequency of cage changes on the health of mice housed in ventilated cages (2001) (135)
Increased Susceptibility of Mice Lacking T-bet to Infection with Mycobacterium tuberculosis Correlates with Increased IL-10 and Decreased IFN-γ Production1 (2005) (133)
Activation of β-catenin signaling in differentiated mammary secretory cells induces transdifferentiation into epidermis and squamous metaplasias (2002) (132)
Reduction in rate of occurrence of age related lesions in dietary restricted laboratory mice. (1991) (131)
The Dual PI3K/mTOR Inhibitor NVP-BEZ235 Induces Tumor Regression in a Genetically Engineered Mouse Model of PIK3CA Wild-Type Colorectal Cancer (2011) (130)
Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis. (2007) (129)
Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis. (2012) (128)
Evidence that MIG-6 is a tumor-suppressor gene (2007) (127)
Mutational landscape of EGFR-, MYC-, and Kras-driven genetically engineered mouse models of lung adenocarcinoma (2016) (127)
Fierce: a new mouse deletion of Nr2e1; violent behaviour and ocular abnormalities are background-dependent (2002) (127)
Dystrophic Muscle in Mice Chimeric for Expression of α5 Integrin (1998) (127)
Thrombospondin-1 gene expression affects survival and tumor spectrum of p53-deficient mice. (2001) (126)
MRI detection of the thermal effects of focused ultrasound on the brain. (2000) (124)
Response and resistance to NF-κB inhibitors in mouse models of lung adenocarcinoma. (2011) (123)
The Effect of Long‐term Dietary Supplementation with Antioxidants a (1998) (123)
In vivo prevention of arterial restenosis with paclitaxel-encapsulated targeted lipid–polymeric nanoparticles (2011) (122)
Does growth hormone prevent or accelerate aging? (1998) (121)
Ena/VASP is required for endothelial barrier function in vivo (2007) (120)
Noonan syndrome cardiac defects are caused by PTPN11 acting in endocardium to enhance endocardial-mesenchymal transformation (2009) (119)
Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma (2016) (117)
The phosphoinositide 3-kinase regulatory subunit p85alpha can exert tumor suppressor properties through negative regulation of growth factor signaling. (2010) (116)
Intestinal Tolerance Is Converted to Autoimmune Enteritis upon PD-1 Ligand Blockade1 (2009) (116)
The RasGAP gene, RASAL2, is a tumor and metastasis suppressor. (2013) (115)
Synergy between PPARγ Ligands and Platinum-Based Drugs in Cancer (2007) (114)
XRCC4 suppresses medulloblastomas with recurrent translocations in p53-deficient mice. (2006) (113)
Serrate2 is disrupted in the mouse limb-development mutant syndactylism (1997) (113)
Lung carcinogenesis induced by chronic tuberculosis infection: the experimental model and genetic control (2009) (112)
The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development. (2012) (112)
Inhibition of CXCR4 in CML cells disrupts their interaction with the bone marrow microenvironment and sensitizes them to nilotinib (2012) (111)
Stabilization of β-catenin induces lesions reminiscent of prostatic intraepithelial neoplasia, but terminal squamous transdifferentiation of other secretory epithelia (2002) (110)
Activating Met mutations produce unique tumor profiles in mice with selective duplication of the mutant allele. (2004) (109)
Mutant Mouse Models Reveal the Relative Roles of E2F1 and E2F3 In Vivo (2002) (106)
A Milieu Molecule for TGF-β Required for Microglia Function in the Nervous System (2018) (105)
E2F3 Loss Has Opposing Effects on Different pRB-Deficient Tumors, Resulting in Suppression of Pituitary Tumors but Metastasis of Medullary Thyroid Carcinomas (2003) (105)
MTDH-SND1 interaction is crucial for expansion and activity of tumor-initiating cells in diverse oncogene- and carcinogen-induced mammary tumors. (2014) (100)
Congenital hypothyroidism, dwarfism, and hearing impairment caused by a missense mutation in the mouse dual oxidase 2 gene, Duox2. (2007) (98)
A new spontaneous mouse mutation of Hoxd13 with a polyalanine expansion and phenotype similar to human synpolydactyly. (1998) (98)
Activation of multiple signaling pathways causes developmental defects in mice with a Noonan syndrome–associated Sos1 mutation. (2010) (98)
Disease incidence and longevity are unaltered by dietary antioxidant supplementation initiated during middle age in C57BL/6 mice (1998) (98)
Increased susceptibility to UV-induced skin carcinogenesis in polymerase eta-deficient mice. (2006) (97)
A very large protein with diverse functional motifs is deficient in rjs (runty, jerky, sterile) mice. (1998) (97)
Comparative Pathology of Nerve Sheath Tumors in Mouse Models and Humans (2004) (96)
Coxsackievirus and adenovirus receptor is essential for cardiomyocyte development (2005) (96)
Targeted disruption of Mig-6 in the mouse genome leads to early onset degenerative joint disease. (2005) (96)
Susceptibility to astrocytoma in mice mutant for Nf1 and Trp53 is linked to chromosome 11 and subject to epigenetic effects. (2004) (96)
Back to the Future: Studying Cholera Pathogenesis Using Infant Rabbits (2010) (95)
The oncogenic lung cancer fusion kinase CD74-ROS activates a novel invasiveness pathway through E-Syt1 phosphorylation. (2012) (94)
Purkinje cell degeneration associated with erythroid ankyrin deficiency in nb/nb mice (1991) (94)
Deletion of the GATA Domain of TRPS1 Causes an Absence of Facial Hair and Provides New Insights into the Bone Disorder in Inherited Tricho-Rhino-Phalangeal Syndromes (2002) (94)
In Vivo Role of INPP4B in Tumor and Metastasis Suppression through Regulation of PI3K-AKT Signaling at Endosomes. (2015) (93)
Broad overexpression of ribonucleotide reductase genes in mice specifically induces lung neoplasms. (2008) (93)
G1 cyclins link proliferation, pluripotency and differentiation of embryonic stem cells (2017) (93)
An Msh2 conditional knockout mouse for studying intestinal cancer and testing anticancer agents. (2010) (92)
MUC1-C ACTIVATES THE TAK1 INFLAMMATORY PATHWAY IN COLON CANCER (2015) (91)
Foxa2 and Cdx2 cooperate with Nkx2-1 to inhibit lung adenocarcinoma metastasis (2015) (91)
Role of F-Box Protein βTrcp1 in Mammary Gland Development and Tumorigenesis (2004) (91)
Oncogenic Deregulation of EZH2 as an Opportunity for Targeted Therapy in Lung Cancer. (2016) (87)
Many ribosomal protein mutations are associated with growth impairment and tumor predisposition in zebrafish (2009) (86)
Effects of p53 mutations on apoptosis in mouse intestinal and human colonic adenomas. (1997) (85)
Establishing a model spinal cord injury in the African green monkey for the preclinical evaluation of biodegradable polymer scaffolds seeded with human neural stem cells (2010) (85)
Mutations in a P-Type ATPase Gene Cause Axonal Degeneration (2012) (85)
Hemagglutinin variants of reovirus type 3 have altered central nervous system tropism. (1983) (85)
SRp38 regulates alternative splicing and is required for Ca(2+) handling in the embryonic heart. (2009) (83)
Aag-initiated base excision repair drives alkylation-induced retinal degeneration in mice (2009) (83)
Induction of human T-cell tolerance to porcine xenoantigens through mixed hematopoietic chimerism. (2004) (82)
The mouse as a model for understanding chronic diseases of aging: the histopathologic basis of aging in inbred mice (2011) (82)
Genetic and structural analysis of a virulence determinant in polyomavirus VP1 (1995) (81)
Apoptosis in ultrasound-produced threshold lesions in the rabbit brain. (2001) (80)
Epstein-Barr virus nuclear antigen 1 does not induce lymphoma in transgenic FVB mice. (2005) (80)
Dp1 is required for extra-embryonic development (2003) (79)
Expression of chemokines in GVHD target organs is influenced by conditioning and genetic factors and amplified by GVHR. (2006) (78)
Autoimmunity as the consequence of a spontaneous mutation in Rasgrp1. (2012) (77)
Acquired MET Expression Confers Resistance to EGFR Inhibition In a Mouse Model of Glioblastoma Multiforme (2011) (77)
Scrambler, a new neurological mutation of the mouse with abnormalities of neuronal migration (1996) (76)
Complete deletion of Apc results in severe polyposis in mice (2009) (76)
Concomitant BRAF and PI3K/mTOR Blockade Is Required for Effective Treatment of BRAFV600E Colorectal Cancer (2013) (74)
Reversible neural stem cell niche dysfunction in a model of multiple sclerosis (2011) (74)
Using combination therapy to override stromal-mediated chemoresistance in mutant FLT3-positive AML: synergism between FLT3 inhibitors, dasatinib/multi-targeted inhibitors and JAK inhibitors (2012) (74)
Murine infection by vesicular stomatitis virus: initial characterization of the H-2d system (1991) (74)
Studies of aging in ames dwarf mice: Effects of caloric restriction (2000) (74)
A Missense Mutation in the Mouse Col2a1 Gene Causes Spondyloepiphyseal Dysplasia Congenita, Hearing Loss, and Retinoschisis (2003) (73)
The critical roles of platelet activation and reduced NO bioavailability in fatal pulmonary arterial hypertension in a murine hemolysis model. (2010) (71)
ZFP191 is required by oligodendrocytes for CNS myelination. (2010) (70)
Lack of Evidence for Neutrophil Participation during Infarct Formation Following Focal Cerebral Ischemia in the Rat (1996) (69)
Neurotrophin receptor TrkB promotes lung adenocarcinoma metastasis (2014) (69)
Sarcomas induced in discrete subsets of prospectively isolated skeletal muscle cells (2011) (69)
Germ-line inactivation of the murine Eck receptor tyrosine kinase by gene trap retroviral insertion. (1996) (68)
Colonic adenocarcinoma associated with chronic colitis in cotton top marmosets, Saguinus oedipus (1981) (68)
D-2-hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice (2014) (68)
Phosphorylation of ETS1 by Src family kinases prevents its recognition by the COP1 tumor suppressor. (2014) (68)
E2f4 is required for normal development of the airway epithelium. (2007) (68)
Type III Secretion Is Essential for the Rapidly Fatal Diarrheal Disease Caused by Non-O1, Non-O139 Vibrio cholerae (2011) (67)
Effects of genotype and diet on age-related lesions in ad libitum fed and calorie-restricted F344, BN, and BNF3F1 rats. (1999) (66)
Tumorigenic activity of merkel cell polyomavirus T antigens expressed in the stratified epithelium of mice. (2015) (65)
Age-related gliosis in the white matter of mice (1993) (65)
Characterization of integrin β6 and thrombospondin‐1 double‐null mice (2005) (65)
MyD88 Deficiency Results in Tissue-Specific Changes in Cytokine Induction and Inflammation in Interleukin-18-Independent Mice Infected with Borrelia burgdorferi (2006) (65)
Encephalitogenic T cells that stably express both T-bet and RORγt consistently produce IFNγ but have a spectrum of IL-17 profiles (2009) (65)
Protein 4.1B suppresses prostate cancer progression and metastasis (2007) (65)
Crucial Role for Early Growth Response-1 in the Transcriptional Regulation of miR-20b in Breast Cancer (2013) (65)
Cell cycle-targeting microRNAs promote differentiation by enforcing cell-cycle exit (2017) (64)
Synergy between PPARgamma ligands and platinum-based drugs in cancer. (2007) (63)
Selection of an appropriate animal model to study aging processes with special emphasis on the use of rat strains. (1992) (63)
Defect in entry and altered pathogenicity of a polyoma virus mutant blocked in VP2 myristylation. (1993) (62)
Pten deficiency activates distinct downstream signaling pathways in a tissue-specific manner. (2006) (61)
E2f3a and E2f3b make overlapping but different contributions to total E2f3 activity (2008) (60)
Retinal degeneration in motor neuron degeneration: a mouse model of ceroid lipofuscinosis. (1994) (60)
Single-Cell Analysis Identifies LY6D as a Marker Linking Castration-Resistant Prostate Luminal Cells to Prostate Progenitors and Cancer (2018) (60)
Ability of herpes simplex virus vectors to boost immune responses to DNA vectors and to protect against challenge by simian immunodeficiency virus. (2007) (60)
β-Cryptoxanthin Supplementation Prevents Cigarette Smoke-Induced Lung Inflammation, Oxidative Damage, and Squamous Metaplasia in Ferrets (2011) (60)
Trak1 mutation disrupts GABAA receptor homeostasis in hypertonic mice (2006) (59)
Increased oxidative phosphorylation in response to acute and chronic DNA damage (2016) (59)
Identification and genetic mapping of a new polycystic kidney disease on mouse chromosome 8. (1997) (59)
Differential Tks5 isoform expression contributes to metastatic invasion of lung adenocarcinoma. (2013) (59)
An Analysis of the Association of Gastroenteric Lesions with Chronic Wasting Syndrome of Marmosets (1982) (58)
Is late- life caloric restriction beneficial? (1995) (58)
Myocardial Infarction Triggers Chronic Cardiac Autoimmunity in Type 1 Diabetes (2012) (57)
Inhibition of EGFR Induces a c‐MET‐Driven Stem Cell Population in Glioblastoma (2014) (57)
Effects of caloric restriction or augmentation in adult rats: Longevity and lesion biomarkers of aging (1998) (57)
Hydrocephalus with hop gait (hyh): a new mutation on chromosome 7 in the mouse. (1990) (56)
Separation of immortalization from tumor induction with polyoma large T mutants that fail to bind the retinoblastoma gene product. (1992) (56)
Mild depletion of dietary folate combined with other B vitamins alters multiple components of the Wnt pathway in mouse colon. (2007) (55)
Absence of a reductase, NCB5OR, causes insulin-deficient diabetes. (2004) (55)
Genetic ablation of NMDA receptor subunit NR3B in mouse reveals motoneuronal and nonmotoneuronal phenotypes (2007) (54)
Thrombosis and secondary hemochromatosis play major roles in the pathogenesis of jaundiced and spherocytic mice, murine models for hereditary spherocytosis. (1997) (54)
A Spontaneous Model for Autoimmune Myocarditis Using the Human MHC Molecule HLA-DQ81 (2004) (54)
Organoids Model Transcriptional Hallmarks of Oncogenic KRAS Activation in Lung Epithelial Progenitor Cells. (2020) (54)
Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer (2013) (53)
Reactogenicity of live-attenuated Vibrio cholerae vaccines is dependent on flagellins (2010) (53)
Enhancement of experimental ulcerative colitis by immunization with Bacteroides vulgatus (1983) (53)
Colonic adenocarcinoma associated with chronic colitis in cotton top marmosets, Saguinus oedipus. (1981) (53)
Analyses of the role of endogenous SPARC in mouse models of prostate and breast cancer (2007) (53)
An Escherichia coli O157-Specific Engineered Pyocin Prevents and Ameliorates Infection by E. coli O157:H7 in an Animal Model of Diarrheal Disease (2011) (53)
A genetic mouse model of invasive endometrial cancer driven by concurrent loss of Pten and Lkb1 Is highly responsive to mTOR inhibition. (2014) (52)
The telomerase inhibitor PinX1 is a major haploinsufficient tumor suppressor essential for chromosome stability in mice. (2011) (52)
O6-methylguanine-induced cell death involves exonuclease 1 as well as DNA mismatch recognition in vivo (2009) (52)
Rb and N-ras Function Together To Control Differentiation in the Mouse (2003) (52)
Estrogen-dependent and estrogen-independent mechanisms contribute to AIB1-mediated tumor formation. (2010) (52)
Hepatocyte Deletion of Triglyceride‐Synthesis Enzyme Acyl CoA: Diacylglycerol Acyltransferase 2 Reduces Steatosis Without Increasing Inflammation or Fibrosis in Mice (2019) (52)
GFP-tagged expression and immunohistochemical studies to determine the subcellular localization of the tubby gene family members. (2000) (51)
T-cell properties determine disease site, clinical presentation, and cellular pathology of experimental autoimmune encephalomyelitis. (2004) (51)
The CD155/TIGIT axis promotes and maintains immune evasion in neoantigen-expressing pancreatic cancer. (2021) (51)
MyD88 Intrinsically Regulates CD4 T-Cell Responses (2008) (50)
Structural Basis for the Transition from Initiation to Elongation Transcription in T 7 RNA Polymerase (50)
Genetic Mechanisms in Apc-Mediated Mammary Tumorigenesis (2009) (50)
Functional genomic screening reveals asparagine dependence as a metabolic vulnerability in sarcoma (2015) (49)
The KDM5A/RBP2 histone demethylase represses NOTCH signaling to sustain neuroendocrine differentiation and promote small cell lung cancer tumorigenesis (2019) (49)
Aag DNA Glycosylase Promotes Alkylation-Induced Tissue Damage Mediated by Parp1 (2013) (49)
Telomere dysfunction promotes genome instability and metastatic potential in a K-ras p53 mouse model of lung cancer. (2008) (49)
The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function. (2017) (49)
Molecular basis of viral neurotropism (1985) (48)
Inhibition of SHP2 ameliorates the pathogenesis of systemic lupus erythematosus. (2016) (48)
Deletion of the MAD2L1 spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell lymphoma and hepatocellular carcinoma (2017) (48)
A mouse model for Meckel syndrome type 3. (2009) (48)
An essential role for IFN-gamma in regulation of alloreactive CD8 T cells following allogeneic hematopoietic cell transplantation. (2007) (47)
Complement Regulator CD59 Protects Against Angiotensin II–Induced Abdominal Aortic Aneurysms in Mice (2010) (47)
Matrix Metalloproteinase 9 Plays a Key Role in Lyme Arthritis but Not in Dissemination of Borrelia burgdorferi (2009) (47)
Brain weight-body weight scaling in breeds of dogs and cats. (1979) (47)
ARF mutation accelerates pituitary tumor development in Rb+/− mice (2002) (46)
Nras loss induces metastatic conversion of Rb1-deficient neuroendocrine thyroid tumor (2006) (45)
Prognosis after surgical excision of cerebral meningiomas in cats: 17 cases (1986-1992). (1993) (45)
Role of aberrant PI3K pathway activation in gallbladder tumorigenesis (2014) (45)
Influence of caloric restriction on motor behavior, longevity, and brain lipid composition in Sandhoff disease mice (2006) (44)
Epigenetic regulation of c-ROS receptor tyrosine kinase expression in malignant gliomas. (2009) (44)
Nephritis and Hemolytic Anemia in Owl Monkeys (Aotus trivirgatus) (1981) (44)
Polyoma virus middle T is essential for virus replication and persistence as well as for tumor induction in mice. (1992) (44)
A Direct Test of Potential Roles for β3 and β5 Integrins in Growth and Metastasis of Murine Mammary Carcinomas (2005) (44)
FOXO protects against age‐progressive axonal degeneration (2017) (43)
Ott1 (Rbm15) Is Essential for Placental Vascular Branching Morphogenesis and Embryonic Development of the Heart and Spleen (2008) (43)
Comparison of Bacteroides vulgatus strains in the enhancement of experimental ulcerative colitis (1987) (43)
Therapeutic benefit of combining calorie-restricted ketogenic diet and glutamine targeting in late-stage experimental glioblastoma (2019) (42)
The mouse mutation "thrombocytopenia and cardiomyopathy" (trac) disrupts Abcg5: a spontaneous single gene model for human hereditary phytosterolemia/sitosterolemia. (2010) (42)
Autotransporters but not pAA are critical for rabbit colonization by Shiga toxin-producing Escherichia coli O104:H4 (2014) (42)
Epstein-Barr Virus Nuclear Antigen 1 Does Not Cause Lymphoma in C57BL/6J Mice (2008) (42)
An imprinted locus epistatically influences Nstr1 and Nstr2 to control resistance to nerve sheath tumors in a neurofibromatosis type 1 mouse model. (2006) (42)
Altered social behavior and neuronal development in mice lacking the Uba6-Use1 ubiquitin transfer system. (2013) (42)
Erratum: Telomere dysfunction induces metabolic and mitochondrial compromise (Nature (2011) 470 (359-365)) (2011) (41)
Nod2 Suppresses Borrelia burgdorferi Mediated Murine Lyme Arthritis and Carditis through the Induction of Tolerance (2011) (41)
Polyoma tumorigenesis in mice: evidence for dominant resistance and dominant susceptibility genes of the host. (1992) (41)
The same systemic autoimmune disease provokes arthritis and endocarditis via distinct mechanisms (2009) (41)
Combination PI3K/MEK inhibition promotes tumor apoptosis and regression in PIK3CA wild-type, KRAS mutant colorectal cancer. (2014) (40)
Selective Requirements for E2f3 in the Development and Tumorigenicity of Rb-Deficient Chimeric Tissues (2007) (40)
Near-Infrared Laser Adjuvant for Influenza Vaccine (2013) (40)
Neuromuscular degeneration (nmd): a mutation on mouse Chromosome 19 that causes motor neuron degeneration (1995) (40)
Loss of the Putative Tumor Suppressor Band 4.1B/Dal1 Gene Is Dispensable for Normal Development and Does Not Predispose to Cancer (2005) (40)
Do-it-yourself (DIY) pathology (2008) (39)
Targeting the human MUC1-C oncoprotein with an antibody-drug conjugate. (2018) (39)
An outbreak of infection by Yersinia pseudotuberculosis in nonhuman primates. (1972) (39)
Organization of cell assemblies in the hippocampus (2003) (39)
The Novel Hsp90 Inhibitor NXD30001 Induces Tumor Regression in a Genetically Engineered Mouse Model of Glioblastoma Multiforme (2010) (39)
A contribution to the electron microscopic morphometric analysis of peripheral nerve (1978) (39)
Adrenocortical dysplasia: a mouse model system for adrenocortical insufficiency. (1994) (38)
A mouse collagen4α4 mutation causing Alport glomerulosclerosis with abnormal collagen α3α4α5(IV) trimers (2013) (38)
γδ T Cells Contribute to Injury in the Developing Brain (2017) (37)
CRISPR-mediated modeling and functional validation of candidate tumor suppressor genes in small cell lung cancer (2019) (37)
Protective effect of Cl-amidine against CLP-induced lethal septic shock in mice (2016) (37)
Husbandry factors and the prevalence of age-related amyloidosis in mice. (1993) (37)
Mice with Mutations in the Mahogany Gene Atrn Have Cerebral Spongiform Changes (2001) (37)
Zebrafish Hagoromo Mutants Up-Regulate fgf8 Postembryonically and Develop Neuroblastoma (2009) (36)
Genetic Interaction between Rb and K-ras in the Control of Differentiation and Tumor Suppression (2004) (36)
Experimental autoimmune peripheral neuritis induced in BALB/c mice by myelin basic protein-specific T cell clones (1995) (36)
Tumor induction by a transformation-defective polyoma virus mutant blocked in signaling through Shc. (1997) (36)
Experimental autoimmune encephalomyelitis-resistant mice have highly encephalitogenic myelin basic protein (MBP)-specific T cell clones that recognize a MBP peptide with high affinity for MHC class II. (1995) (36)
A Test of the Role of α5 Integrin/Fibronectin Interactions in Tumorigenesis (1998) (35)
The fibrinolytic system facilitates tumor cell migration across the blood-brain barrier in experimental melanoma brain metastasis (2006) (35)
Intergenerational epigenetic inheritance of cancer susceptibility in mammals (2019) (35)
Lesion biomarkers of aging in B6C3F1 hybrid mice. (1999) (35)
A dynamic switch in Rb+/− mediated neuroendocrine tumorigenesis (2004) (35)
Rapid conditional targeted ablation of cells expressing human CD59 in transgenic mice by intermedilysin (2008) (34)
Development of a Colon Cancer GEMM-Derived Orthotopic Transplant Model for Drug Discovery and Validation (2013) (34)
Selective Inhibition of SIRT2 Improves Outcomes in a Lethal Septic Model (2015) (33)
Dysferlin overexpression in skeletal muscle produces a progressive myopathy (2009) (33)
Inactivation of conditional Rb by Villin-Cre leads to aggressive tumors outside the gastrointestinal tract. (2006) (33)
Generation of Genetically Engineered Mouse Lung Organoid Models for Squamous Cell Lung Cancers Allows for the Study of Combinatorial Immunotherapy (2020) (33)
A novel mycobacterial Hsp70-containing fusion protein targeting mesothelin augments antitumor immunity and prolongs survival in murine models of ovarian cancer and mesothelioma (2014) (32)
Kinase domain activation of FGFR2 yields high-grade lung adenocarcinoma sensitive to a Pan-FGFR inhibitor in a mouse model of NSCLC. (2014) (32)
Neural blastocyst complementation enables mouse forebrain organogenesis (2018) (31)
Mutations in Hedgehog pathway genes in fetal rhabdomyomas (2013) (31)
Adult mice lacking the p53/p63 target gene Perp are not predisposed to spontaneous tumorigenesis but display features of ectodermal dysplasia syndromes (2006) (31)
Genetic ablation of metadherin inhibits autochthonous prostate cancer progression and metastasis. (2014) (31)
T-cell responses to myelin basic protein in normal and MBP-deficient mice (1998) (31)
A direct test of potential roles for beta3 and beta5 integrins in growth and metastasis of murine mammary carcinomas. (2005) (31)
Interleukin‐6 is Required for Pristane‐Induced Plasma Cell Hyperplasia In Mice (1996) (31)
Mesenchymal dysplasia: a recessive mutation on chromosome 13 of the mouse. (1996) (31)
PDK1 attenuation fails to prevent tumor formation in PTEN-deficient transgenic mouse models. (2011) (31)
GPR56 Plays varying roles in endogenous cancer progression (2010) (30)
Spontaneous fracture (sfx): a mouse genetic model of defective peripubertal bone formation. (2000) (30)
Rostral cerebellar malformation, (rcm): a new recessive mutation on chromosome 3 of the mouse. (1992) (29)
Deletion of Interstitial Genes between TMPRSS2 and ERG Promotes Prostate Cancer Progression. (2016) (29)
Spontaneous Pallido‐Nigral Accumulation of Iron Pigment and Spheroid‐like Structures in Macaque Monkeys (1980) (29)
Tumor progression in Apc1638N mice with Exo1 and Fen1 deficiencies (2007) (29)
A suppressive role of ionizing radiation-responsive miR-29c in the development of liver carcinoma via targeting WIP1 (2015) (29)
Keap1 mutation renders lung adenocarcinomas dependent on Slc33a1 (2020) (29)
Kinase-independent function of E-type cyclins in liver cancer (2018) (29)
A PDGFRα-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine (2018) (29)
CD11c+ Dendritic Cells Accelerate the Rejection of Older Cardiac Transplants via Interleukin-17A (2015) (29)
Pyvs: a dominantly acting gene in C3H/BiDa mice conferring susceptibility to tumor induction by polyoma virus. (1993) (28)
Chronic activation of wild-type epidermal growth factor receptor and loss of Cdkn2a cause mouse glioblastoma formation. (2011) (28)
Calorie restriction modulates age-dependent changes in the retinas of Brown Norway rats (2000) (28)
Mice lacking the p53/p63 target gene Perp are resistant to papilloma development. (2005) (28)
NF1 deficiency correlates with estrogen receptor signaling and diminished survival in breast cancer (2018) (28)
Polyoma Virus-Induced Osteosarcomas in Inbred Strains of Mice: Host Determinants of Metastasis (2010) (28)
Dietary supplementation with mushroom-derived protein-bound glucan does not enhance immune function in young and old mice. (1998) (28)
Pleiotrophin is an important regulator of the renin-angiotensin system in mouse aorta. (2004) (28)
Ontak-like human IL-2 fusion toxin. (2017) (28)
Forebrain overgrowth (fog): a new mutation in the mouse affecting neural tube development. (1997) (28)
Metastasis-associated MCL1 and P16 copy number alterations dictate resistance to vemurafenib in a BRAFV600E patient-derived papillary thyroid carcinoma preclinical model (2015) (28)
Developmental SHP2 dysfunction underlies cardiac hypertrophy in Noonan syndrome with multiple lentigines. (2016) (27)
DOCK8 enforces immunological tolerance by promoting IL-2 signaling and immune synapse formation in Tregs. (2017) (27)
Therapeutic benefit of combining calorie-restricted ketogenic diet and glutamine targeting in late-stage experimental glioblastoma (2019) (27)
Near-Infrared 1064 nm Laser Modulates Migratory Dendritic Cells To Augment the Immune Response to Intradermal Influenza Vaccine (2017) (27)
Targeted disruption of fibrinogen like protein-1 accelerates hepatocellular carcinoma development. (2015) (26)
Immediate-early Gene Expression in Ovine Brain after Cardiopulmonary Bypass and Hypothermic Circulatory Arrest (1996) (26)
Discovery and characterization of spontaneous mouse models of craniofacial dysmorphology. (2016) (26)
Induced p53 loss in mouse luminal cells causes clonal expansion and development of mammary tumours (2017) (26)
Contrasting roles of dietary selenium and selenoproteins in chemically induced hepatocarcinogenesis. (2013) (26)
Tumor Suppression by a Severely Truncated Species of Retinoblastoma Protein (2002) (26)
Genetic ablation of alphav integrins in epithelial cells of the eyelid skin and conjunctiva leads to squamous cell carcinoma. (2008) (26)
Maternal B vitamin supplementation from preconception through weaning suppresses intestinal tumorigenesis in Apc1638N mouse offspring (2011) (26)
Therapeutic efficacy of vitamin E and selenium in treating hemolytic anemia of owl monkeys (Aotus trivirgatus). (1980) (25)
Pleiotrophin is a major regulator of the catecholamine biosynthesis pathway in mouse aorta. (2004) (25)
Regulation of Postsurgical Fibrosis by the Programmed Death-1 Inhibitory Pathway1 (2004) (25)
Retraction. Autoimmunity as the consequence of a spontaneous mutation in Rasgrp1. (2003) (25)
Curly bare (cub), a new mouse mutation on chromosome 11 causing skin and hair abnormalities, and a modifier gene (mcub) on chromosome 5. (2003) (25)
Notch1-induced brain tumor models the sonic hedgehog subgroup of human medulloblastoma. (2013) (25)
Inhibition of pituitary tumors in Rb mutant chimeras through E2f4-loss reveals a key suppressive role for the pRB/E2F pathway in urothelium and ganglionic carcinogenesis (2008) (24)
Brain weight‐body weight relationships in 12 species of nonhuman primates (1981) (24)
IGF-1:Tetanus toxin fragment C fusion protein improves delivery of IGF-1 to spinal cord but fails to prolong survival of ALS mice (2009) (24)
Further Characterization of Reproductive Abnormalities in mCd59b Knockout Mice: A Potential New Function of mCd59 in Male Reproduction1 (2005) (24)
Erratum: Classification of proliferative pulmonary lesions of the mouse: Recommendations of the mouse models of human cancers consortium (Cancer Research (April 1, 2004) 64 (2307-2316)) (2004) (24)
Histone deacetylase III as a potential therapeutic target for the treatment of lethal sepsis (2014) (24)
Human risk allele HLA-DRB1*0405 predisposes class II transgenic Ab0 NOD mice to autoimmune pancreatitis. (2010) (24)
Adoptive transfer of immune enhancement of experimental ulcerative colitis (1984) (24)
Genetic and age related models of neurodegeneration in mice: dystrophic axons. (1992) (24)
Wild-Derived Inbred Mice Have a Novel Basis of Susceptibility to Polyomavirus-Induced Tumors (1999) (24)
Epigenetic states of cells of origin and tumor evolution drive tumor-initiating cell phenotype and tumor heterogeneity. (2014) (23)
The nonhomologous end joining factor Artemis suppresses multi-tissue tumor formation and prevents loss of heterozygosity (2007) (23)
SMARCA4 inactivation promotes lineage-specific transformation and early metastatic features in the lung. (2021) (23)
A retrospective study of infant mortality of cotton-top tamarins (Saguinus oedipus) in captive breeding. (1983) (23)
ROS1 signaling regulates epithelial differentiation in the epididymis. (2014) (23)
TAZ Promotes PC 2 Degradation through a SCF-Trcp E 3 Ligase Complex † (2007) (23)
Loss of Rb1 in the gastrointestinal tract of Apc1638N mice promotes tumors of the cecum and proximal colon (2008) (22)
Cardiac Conduction Abnormalities in a Mouse Model of Lyme Borreliosis (2001) (22)
Defective spectrin integrity and neonatal thrombosis in the first mouse model for severe hereditary elliptocytosis. (2001) (22)
DOK2 Inhibits EGFR-Mutated Lung Adenocarcinoma (2013) (22)
The CD155/TIGIT Axis Promotes and Maintains Immune Evasion in Neoantigen-Expressing Pancreatic Cancer (2020) (22)
Long term post-traumatic retrograde corticospinal degeneration in man. (1978) (22)
Megencephaly: a new mouse mutation on chromosome 6 that causes hypertrophy of the brain (1996) (22)
Inhibition of sphingolipid synthesis improves outcomes and survival in GARP mutant wobbler mice, a model of motor neuron degeneration (2020) (22)
Elevated Id2 Expression Results in Precocious Neural Stem Cell Depletion and Abnormal Brain Development (2013) (21)
Isoform-specific deletion of PKM2 constrains tumor initiation in a mouse model of soft tissue sarcoma (2018) (21)
Fatal fasting syndrome of obese macaques. (1982) (21)
Naked Mole Rat Induced Pluripotent Stem Cells and Their Contribution to Interspecific Chimera (2017) (21)
Selective histone deacetylase-6 inhibition attenuates stress responses and prevents immune organ atrophy in a lethal septic model. (2014) (21)
Inactivation of the retinoblastoma gene yields a mouse model of malignant colorectal cancer (2015) (20)
Alström syndrome is associated with short stature and reduced GH reserve (2013) (20)
Abnormal Regulatory and Effector T Cell Function Predispose to Autoimmunity following Xenogeneic Thymic Transplantation1 (2008) (20)
Deletion of the p 27 Kip 1 gene restores normal development in cyclin D 1-deficient mice (2000) (19)
BRG1 Loss Predisposes Lung Cancers to Replicative Stress and ATR Dependency (2020) (19)
A test of the role of alpha5 integrin/fibronectin interactions in tumorigenesis. (1998) (19)
Spatially distinct roles of class Ia PI3K isoforms in the development and maintenance of PTEN hamartoma tumor syndrome. (2013) (19)
Alkyl phospholipid perifosine induces myeloid hyperplasia in a murine myeloma model. (2007) (18)
Pancreatic ectasia in uremic macaques. (1982) (18)
Hematopoietic cells from -spectrin-deficient mice are sufficient to induce thrombotic events in hematopoietically ablated recipients. (1998) (18)
Noma in a nonhuman primate. (1981) (18)
BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1α activation (2018) (18)
Colon-specific tumorigenesis in mice driven by Cre-mediated inactivation of Apc and activation of mutant Kras. (2014) (18)
Temporal and spatial specificity of PDGF alpha receptor promoter in transgenic mice. (1997) (18)
Semiconductor diode laser device adjuvanting intradermal vaccine. (2017) (18)
Niche-localized tumor cells are protected from HER2-targeted therapy via upregulation of an anti-apoptotic program in vivo (2017) (18)
Ablation of insulin receptor substrates 1 and 2 suppresses Kras-driven lung tumorigenesis (2018) (18)
Receptor-Binding and Oncogenic Properties of Polyoma Viruses Isolated from Feral Mice (2007) (18)
Myelogenous leukemia in adult inbred MHC-defined miniature swine: a model for human myeloid leukemias. (2010) (17)
A genetic platform to model sarcomagenesis from primary adult mesenchymal stem cells. (2015) (16)
Neutralization of BCL-2/XL Enhances the Cytotoxicity of T-DM1 In Vivo (2019) (16)
Radiation-Resistant and Radiation-Sensitive Forms of Host Resistance to Polyomavirus (1999) (16)
p600 Plays Essential Roles in Fetal Development (2013) (16)
INHERITED NECROTIZING MYELOPATHY OF AFGHAN HOUNDS (1977) (16)
Calorie restriction increases light-dependent photoreceptor cell loss in the neural retina of Fischer 344 rats (2000) (16)
Stochastic Model of Tsc1 Lesions in Mouse Brain (2013) (15)
A retrovirus carrying the K-fgf oncogene induces diffuse meningeal tumors and soft-tissue fibrosarcomas (1993) (15)
Miniature Swine as a Clinically Relevant Model of Graft-Versus-Host Disease. (2015) (15)
Phenotypic Characterization of the KK/HlJ Inbred Mouse Strain (2014) (15)
Effect of vitamin E supplementation on prostaglandin concentrations in aspirin-induced acute gastric injury in aged rats. (1997) (15)
Expression of oncogenic BRAFV600E in melanocytes induces Schwannian differentiation in vivo (2015) (14)
Targeting the cyclin-dependent kinase 5 in metastatic melanoma (2020) (14)
The role of pathology in rodent experimental gerontology (1993) (14)
Over 60% of NIH extramural funding involves animal-related research (2007) (14)
Navitoclax enhances the effectiveness of EGFR-targeted antibody-drug conjugates in PDX models of EGFR-expressing triple-negative breast cancer (2020) (14)
A Spontaneous Mutation in Contactin 1 in the Mouse (2011) (13)
The effect of dietary glutathione and coenzyme Q10 on the prevention and treatment of inflammatory bowel disease in mice. (2004) (13)
Compound haploinsufficiency of Dok2 and Dusp4 promotes lung tumorigenesis (2018) (13)
The Combination of Curcumin and Salsalate is Superior to Either Agent Alone in Suppressing Pro‐Cancerous Molecular Pathways and Colorectal Tumorigenesis in Obese Mice (2019) (13)
Survival benefit and phenotypic improvement by hamartin gene therapy in a tuberous sclerosis mouse brain model (2015) (13)
E‐Cadherin Loss Accelerates Tumor Progression and Metastasis in a Mouse Model of Lung Adenocarcinoma (2018) (13)
ALKBH7 drives a tissue and sex-specific necrotic cell death response following alkylation-induced damage (2017) (13)
Oncogenic Deregulation of EZH 2 as an Opportunity for Targeted Therapy in Lung Cancer (2016) (12)
Gene therapy for tuberous sclerosis complex type 2 in a mouse model by delivery of AAV9 encoding a condensed form of tuberin (2021) (12)
Type III Secretion Is Essential for the Rapidly Fatal Diarrheal Disease Caused by NonO 1 , NonO 139 Vibrio cholerae (2011) (12)
Morphometric analysis of the effects of exenteration and enucleation on the development of third and sixth cranial nerves in the rat (1977) (12)
Diminished lifespan and acute stress-induced death in DNA-PKcs-deficient mice with limiting telomeres (2007) (12)
Role of novel protein kinase C isoforms in Lyme arthritis (2007) (12)
Evidence that lysosomal storage of proteolipids is a cell autonomous process in the motor neuron degeneration (mnd) mouse, a model of neuronal ceroid lipofuscinosis (1996) (12)
Histopathology of the Human Inner Ear in Alström's Syndrome (2015) (11)
Immediate-early gene expression in ovine brain after hypothermic circulatory arrest: effects of aptiganel. (1997) (11)
The impact of the MYB-NFIB fusion proto-oncogene in vivo (2016) (11)
The Phosphoinositide 3-Kinase Regulatory Subunit p85 Can Exert Tumor Suppressor Properties through Negative Regulation of Growth Factor Signaling (2010) (11)
Imbalance between apoptosis and cell proliferation during early stages of mammary gland carcinogenesis in ACI rats. (2010) (11)
Parp1 protects against Aag-dependent alkylation-induced nephrotoxicity in a sex-dependent manner (2016) (11)
Cerebellar deficient folia (cdf): A new mutation on mouse Chromosome 6 (1997) (11)
Osteochondrodystrophy (ocd): a new autosomal recessive mutation in the mouse. (1991) (11)
Paralytic Autoimmune Myositis Develops in Nonobese Diabetic Mice Made Th1 Cytokine-Deficient by Expression of an IFN-γ Receptor β-Chain Transgene1 (2003) (11)
Meconium corpuscles in intestinal epithelium of fetal and newborn primates. (1974) (11)
Lymphomagenesis and female-specific lethality in p53-deficient mice occur independently of E2f1 (2004) (11)
Graft-versus-host disease can be separated from graft-versus-lymphoma effects by control of lymphocyte trafficking with FTY 720 (2003) (10)
Rapid Dendritic Cell Activation and Resistance to Allotolerance Induction in Anti-CD154-Treated Mice Receiving CD47-Deficient Donor-Specific Transfusion (2014) (10)
Control of Glucocorticoid Receptor Levels by PTEN Establishes a Failsafe Mechanism for Tumor Suppression. (2020) (10)
Repair of endogenous DNA base lesions modulate lifespan in mice. (2014) (10)
Systemic administration of a deoxyribozyme to xylosyltransferase-1 mRNA promotes recovery after a spinal cord contusion injury (2012) (10)
Long-Term Therapeutic Efficacy of Intravenous AAV-Mediated Hamartin Replacement in Mouse Model of Tuberous Sclerosis Type 1 (2019) (10)
Retroposon compensatory mechanism hypothesis not supported: Zfa knockout mice are fertile. (2003) (10)
Transgenic mice with a mutated collagen promoter display normal response during bleomycin‐induced fibrosis and possess neurological abnormalities (2000) (10)
Autochthonous tumors driven by Rb1 loss have an ongoing requirement for the RBP2 histone demethylase (2018) (10)
Differential recognition of MBP epitopes in BALB/c mice determines the site of inflammatory disease induction (1998) (10)
Genotype Directed Therapy in Murine Mismatch Repair Deficient Tumors (2013) (9)
Perinatal Natural History of the Ts1Cje Mouse Model of Down Syndrome: Growth Restriction, Early Mortality, Heart Defects, and Delayed Development (2016) (9)
1. Generation by Homologous Recombination and Characterization (1993) (9)
How to study pathologic phenotypes of knockout mice. (2001) (9)
Brain and Testicular Tumors in Mice with Progenitor Cells Lacking BAX and BAK (2012) (9)
A portable single-sided magnetic-resonance sensor for the grading of liver steatosis and fibrosis (2020) (9)
Nonalloreactive T Cells Prevent Donor Lymphocyte Infusion–Induced Graft-versus-Host Disease by Controlling Microbial Stimuli (2012) (9)
Progenitor potential of lung epithelial organoid cells in a transplantation model (2022) (9)
Strain- and Diet-Related Lesion Variability in Aging DBA/2, C57BL/6, and DBA/2xC57BL/6 F1 Mice (2016) (9)
Age at death of necropsied intact and neutered cats. (1981) (9)
A Vascular Model of Tsc1 Deficiency Accelerates Renal Tumor Formation with Accompanying Hemangiosarcomas (2014) (9)
Nutritional evaluation in cotton-top tamarins (Saguinus oedipus). (1981) (8)
Expression of Stromal Cell–Derived Factor-1 by Mesenchymal Stromal Cells Impacts Neutrophil Function During Sepsis (2020) (8)
MyD 88 Intrinsically Regulates CD 4 T-Cell Responses (2014) (8)
Divergent Roles of PI3K Isoforms in PTEN-Deficient Glioblastomas (2020) (8)
Protein-losing enteropathy in six macaques. (1980) (8)
Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma (2021) (8)
Germline loss of PKM 2 promotes metabolic distress and hepatocellular carcinoma (2016) (8)
Ganglioneuropathy in rabbits and a rhesus monkey due to high cumulative doses of doxorubicin. (1982) (7)
Donor Lymphocyte Infusion-Mediated Graft-versus-Host Responses in a Preclinical Swine Model of Haploidentical Hematopoietic Cell Transplantation. (2016) (7)
Mice with hepatocyte-specific deficiency of type 3 deiodinase have intact liver regeneration and accelerated recovery from nonthyroidal illness after toxin-induced hepatonecrosis. (2014) (7)
evidence of strain-specific effects (2000) (7)
Towards a biomarker of mammalian senescence: carbonic anhydrase III. (1988) (7)
Chronic platelet-derived growth factor receptor signaling exerts control over initiation of protein translation in glioma (2018) (7)
Heterogeneity of EAE mediated by multiple distinct T-effector subsets (2007) (7)
Genetic Interaction between Tmprss2-ERG Gene Fusion and Nkx3.1-Loss Does Not Enhance Prostate Tumorigenesis in Mouse Models (2015) (7)
Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene (2001) (6)
A Retrospective Study of Etiological Factors of Abortion in the Owl Monkey, Aotus trivirgatus 1 (1981) (6)
Harlequin (Hw) produces progressive cerebellar cortical atrophy. (1990) (6)
Increased PHGDH expression promotes aberrant melanin accumulation (2019) (6)
The Phosphoinositide 3-Kinase Regulatory Subunit p 85 Can Exert Tumor Suppressor Properties through Negative Regulation of Growth Factor Signaling (2011) (6)
Necrotizing myopathy associated with hemolytic anemia in owl monkeys (Aotus trivirgatus) (1980) (6)
Failure of Herpesvirus saimiri to enhance atherogenesis in owl monkeys (Aotus trivirgatus). (1983) (5)
Targeted disruption of pi07: functional overlap between pl07 and Rb (1996) (5)
Trembly-like (Tyl) - a new X-linked mutation in the mouse. (1990) (5)
Selective Inhibition of SIRT2 Improves Outcomes in a Lethal Septic Model (2015) (5)
Ultrastructure of Macrophages and Karyolytic Bodies in Small Intestinal Villi of Macaque Monkeys and Baboons (1981) (5)
The crucial role of DNA-dependent protein kinase and myelin transcription factor 1-like protein in the miR-141 tumor suppressor network (2019) (4)
Clinical viability of magnetic bead implants in muscle (2022) (4)
Spontaneous Pallidonigral Spheroids and Iron Pigment Accumulation, Macaques (1993) (4)
Adenomatous Polyposis Coli ( APC ) Is Required for Normal (2006) (4)
Phosphorylation of ETS 1 by Src Family Kinases Prevents Its Recognition by the COP 1 Tumor Suppressor (2014) (4)
Removal of a Membrane Anchor Reveals the Opposing Regulatory Functions of Vibrio cholerae Glucose-Specific Enzyme IIA in Biofilms and the Mammalian Intestine (2018) (4)
Mismatch repair deficiency is not sufficient to increase tumor immunogenicity (2021) (4)
Growth and Metastasis of Murine Mammary Carcinomas 5 Integrins in β 3 and β A Direct Test of Potential Roles for Updated (2005) (4)
Involution of placental site and corpus luteum in the monkey. (1972) (4)
Murine Lung Cancer Alleles on Advanced p 53 The Differential Effects of Mutant Updated (2005) (4)
Abstract P4-08-05: Basement membrane localized tumor cells are protected from HER2-targeted therapy in vivo. (2012) (4)
ConcomitantBRAFandPI3K/mTORBlockadeIsRequiredfor Effective Treatment of BRAF V600E Colorectal Cancer (2013) (3)
Rostral cerebellar malformation (rcm). (1990) (3)
Long-term monitoring of inflammation in the mammalian gut using programmable commensal bacteria (2016) (3)
Karyotypic variation in susceptibility to hemolytic anemia and idiopathic eosinophilia of owl monkeys,Aotus trivirgatus (1981) (3)
SPONTANEOUS PALLIDO-NIGRAL SPHEROID PIGMENTARY DEGENERATION IN MONKEYS: AN ANALOG OF HUMAN HALLERVORDEN-SPATZ DISEASE (1977) (3)
BRAF V600E and Pten deletion in mice produces a histiocytic disorder with features of Langerhans cell histiocytosis (2019) (3)
Distinct Malignant Behaviors of Mouse Myogenic Tumors Induced by Different Oncogenetic Lesions (2015) (3)
Induction of Histiocytic Sarcoma in Mouse Skeletal Muscle (2012) (3)
BRCA1/Trp53 heterozygosity and replication stress drive esophageal cancer development in a mouse model (2021) (3)
Deletion of the MAD 2 L 1 spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell lymphoma and hepatocellular carcinoma (2017) (3)
The PI3K regulatory subunit p85α can exert tumor suppressor properties through negative regulation of growth factor signalling (2011) (3)
Altered histopathology in protein-deprived mice during Sendai virus pneumonia: evidence for delayed inflammatory response and recovery. (1992) (3)
Program and abstracts for the 2012 Joint Meeting of the Society for Glycobiology & American Society for Matrix Biology (2012) (2)
Effects of Lutein Supplementation on the Prevention of Colonic Inflammation and Neoplasia in Mice (2015) (2)
Paralytic autoimmune myositis develops in nonobese diabetic mice made Th1 cytokine-deficient by expression of an IFN-gamma receptor beta-chain transgene. (2003) (2)
The mutational landscape of EGFR-, MYC-, and Kras- driven genetically-engineered mouse models of lung adenocarcinoma (2016) (2)
Pathologic phenotyping of mutant mice. (2009) (2)
Thrombocytopenia and Cardiomyopathy ( trac ): A New Single Gene Mutation Resulting in Severe Platelet and Heart Abnormalities in Mice. (2005) (2)
Epstein-Barr Virus Nuclear Antigen 1 Does Not Cause Lymphoma in C 57 BL / 6 J Mice (2008) (2)
Biological Effects of Inactivation of the Genes for Tissue-type Plasminogen Activator, Urokinase-type Plasminogen Activator and Plasminogen Activator Inhibitor-1 in Mice (1993) (2)
Unrecognized "AIDS" in Monkeys, 1969-1980: Explanations and Implications. (2016) (2)
Abstract B27: Improved survival with erdafitinib (JNJ-42756493) and PD-1 blockade mediated by enhancement of anti-tumor immunity in an FGFR2-driven genetically engineered mouse model of lung cancer (2017) (2)
ReproductionPotential New Function of mCd59 in Male Knockout Mice: A mCd59b Abnormalities in Further Characterization of Reproductive (2005) (2)
The Dual PI3K/mTOR Inhibitor NVP-BEZ235 Induces Tumor Regression in a Genetically Engineered Mouse Model for Sporadic Colorectal Cancer (2011) (2)
Rate of Accumulation of Luxol Fast Blue Staining Material and Mitochondrial ATP Synthase Subunit 9 in Motor Neuron Degeneration Mice (1998) (2)
Age and diet alter skeletal muscle tubular aggregates (1995) (2)
Diet restriction and age alters skeletal muscle capillarity in B6C3F1 mice (2000) (1)
Targeted inhibition of Wnt signaling with a bacterial toxin fragment suppresses breast cancer tumor-initiating/chemo-resistant cells (2020) (1)
Oncogenic Events Dictate the Types and Locations of Gynecological Malignancies Originating from Krt8+ Mesothelial and Müllerian-Derived Epithelial Cells (2022) (1)
Morphology and morphogenesis of cerebral ring hemorrhages in anemic monkeys (2004) (1)
2685: Utilizing Mouse Genetics to Dissect the Cellular Target and Molecular Mechanism of Acute and Late Toxicity of Abdominal Radiation Therapy (2006) (1)
Shimmy (shmy), a new mutation on chromosome 14 of the mouse (1994) (1)
Fine Mapping of a Deafness Mutation hml on Mouse Chromosome 10. (2004) (1)
Erratum: Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKCλ/ζ (Cell Metabolism (2006) 3 (343-353)) (2016) (1)
Tumorigenesis and Neoplastic Progression Genetic Ablation of ! v Integrins in Epithelial Cells of the Eyelid Skin and Conjunctiva Leads to Squamous Cell Carcinoma (2008) (1)
Neuromuscular ataxia: a new spontaneous mutation in the mouse (2000) (1)
Adoptive Transfer ofImmuneEnhancement ofExperimental Ulcerative Colitis (1984) (1)
Grey intense: a new mouse mutation affecting pigmentation (2000) (1)
Corrigendum: Trak1 mutation disrupts GABAA receptor homeostasis in hypertonic mice (2006) (1)
Author response: Intergenerational epigenetic inheritance of cancer susceptibility in mammals (2019) (1)
Combined Supplementation with Vitamin B-6 and Curcumin is Superior to Either Agent Alone in Suppressing Obesity-Promoted Colorectal Tumorigenesis in Mice. (2021) (1)
Increased PHGDH expression uncouples hair follicle cycle progression and promotes inappropriate melanin accumulation (2018) (1)
P1-416 APP processing and cell cycle reentry signaling pathways are involved in p25/cdk5-mediated neurodegeneration (2006) (0)
Abstract A40: Class IIa HDAC inhibition promotes an anti-tumor macrophage phenotype that induces breast tumor regression and inhibits metastasis (2016) (0)
Dietary lutein inhibits DSS-induced colitis and associated colorectal carcinoma development in mice (2008) (0)
invasion of lung adenocarcinoma isoform expression contributes to metastatic Tks 5 Differential Material Supplemental (2013) (0)
Mismatch repair deficiency is not sufficient to elicit tumor immunogenicity (2021) (0)
An analysis of the association of gastroenteric lesions with chronic wasting syndrome of marmosets. (1982) (0)
Lymphangiogenesis Is Unnecessary for Lymph Node Necessary for Prostate Cancer Lymphangiogenesis, but Tumor-Secreted Vascular Endothelial Growth Factor-C Is (2005) (0)
Glutathione supports lipid abundance in vivo (2023) (0)
Vascular Branching Morphogenesis of the Placenta Requires Expression of Ott1(Rbm15) in the Trophoblast Compartment. (2008) (0)
Abstract 5393: ETV1 directs androgen metabolism and confers aggressive prostate cancer in engineered mice and patients. (2013) (0)
The MGH Miniature Swine as a Large Animal Model of HCT and Graft Versus Host Disease (2013) (0)
Increased PHGDH expression promotes aberrant melanin accumulation (2019) (0)
Abstract P3-11-06: Pre-clinical assessment of combined ABT-263/Navitoclax and ABT-414 or ABBV-321 treatment for EGFR-expressing TNBC (2020) (0)
CALORIC RESTRICTION ALTERS CAPILLARY DENSITY AND SKELETAL MUSCLE FIBER AREA WITH AGE IN B6C3F1 MICE.: 1318 (1995) (0)
Cancer Therapy : Preclinical Concomitant BRAFandPI 3 K / mTORBlockade IsRequired for Effective Treatment of BRAFV 600 E Colorectal Cancer (2013) (0)
airway responsiveness in inbred mice forced oscillation for identifying genetic variability of Comparison of unrestrained plethysmography and (2015) (0)
Abstract LB-146: Identification of copy number alterations in small cell lung cancer (2010) (0)
Abstract 4627: Mutant p53 regulation in a Li-Fraumeni mouse model (2019) (0)
Erratum: Niche-localized tumor cells are protected from HER2-targeted therapy via upregulation of an anti-apoptotic program in vivo (2017) (0)
Abstract 832: Effects of beta-cryptoxanthin on cigarette smoke-induced lung oxidative damage, inflammation and activation of NF-kappa B and AP-1 (2011) (0)
Niche-localized tumor cells are protected from HER2-targeted therapy via upregulation of an anti-apoptotic program in vivo (2017) (0)
Erratum: Niche-localized tumor cells are protected from HER2-targeted therapy via upregulation of an anti-apoptotic program in vivo (2017) (0)
Viral Induced Skin Tumors in Mice (2020) (0)
Programmed Death-1 Inhibitory Pathway Regulation of Postsurgical Fibrosis by the and (2004) (0)
Granulocytosis and Lymphopenia After Adoptive Transfer of NF-κB Deficient Fetal Liver Cells. • 661 (1997) (0)
P2-120 APP-related pathology in a P25/CDK5 transgenic model of Alzheimer's disease (2004) (0)
Therapeutics , Targets , and Chemical Biology PDK 1 Attenuation Fails to Prevent Tumor Formation in PTEN-Deficient Transgenic Mouse Models (2011) (0)
Abstract IA17: The role of the senescence-associated secretory phenotype in cancer (2021) (0)
Lesion Biomarkers ofAging in B6C3Fl Hybrid Mice (1999) (0)
Neural blastocyst complementation enables mouse forebrain organogenesis (2018) (0)
DIET RESTRICTION ALTERS SKELETAL MUSCLE MITOCHONDRIAL PLASTICITY IN AGING MICE (1999) (0)
Murine Chromosomal Regions Correlated With Longevity (2002) (0)
mixed hematopoietic chimerism Induction of human T-cell tolerance to porcine xenoantigens through (2013) (0)
196. AAV-Mediated Gene Replacement Therapy in Mouse Model of Tuberous Sclerosis (2015) (0)
Fitm2 is required for ER homeostasis and normal function of murine liver (2022) (0)
Abstract 5478: The TRPA1 Ca2+-permeable channel mediates a non-canonical redox adaptation in cancer cells (2017) (0)
-Chain Transgene b Receptor g Cytokine-Deficient by Expression of an IFN-Nonobese Diabetic Mice Made Th1 Paralytic Autoimmune Myositis Develops in (2003) (0)
Allogeneic TransplantsDonor Leukocyte Infusion Mediated Graft-Versus-Host Responses in a Pre-Clinical Swine Model of Haploidentical Hematopoietic Cell Transplantation (2016) (0)
Decreased IFN-Correlates with Increased IL-10 tuberculosis Mycobacterium T-bet to Infection with Increased Susceptibility of Mice Lacking and (2005) (0)
Abstract B35: Class IIa HDAC inhibition promotes an antitumor macrophage phenotype that induces breast tumor regression and inhibits metastasis (2018) (0)
Tumor-Initiating Cell Phenotype and Tumor Heterogeneity Epigenetic States of Cells of Origin and Tumor Evolution Drive (2014) (0)
Abstract 2965: ERG and ETV1 regulate a common transcriptional network in prostate cells but in an opposite fashion (2012) (0)
Abstract LB-151: Targeted gene resequencing in a K-ras-dependent mouse model of metastatic lung adenocarcinoma (2010) (0)
Juvenile bare: a new hair loss mutation on chromosome 7 of the mouse. (1998) (0)
Oncogenic KRAS supports pancreatic cancer through regulation of nucleotide synthesis (2018) (0)
Novel Hsp90 Inhibitor NXD30001 Induces Tumor ression in a Genetically Engineered Mouse (2010) (0)
Parathyroid Hormone Dire cts Bone Marrow Mesenchymal Cell Fate Graphical (2017) (0)
Abstract 5201: Elucidating distinct roles for NF1 in melanomagenesis. (2013) (0)
Use of cellular context to determine sarcoma phenotype in a new mouse sarcoma model. (2011) (0)
Abstract B39: Nkx2-1 down-regulation underlies lung adenocarcinoma progression towards malignancy (2009) (0)
Abstract LB-330: Endogenous T cell responses to lung adenocarcinoma neoantigens delay malignant tumor progression (2010) (0)
Maternal B‐vitamin supplementation from preconception through weaning suppresses intestinal tumorigenesis among offspring in the Apc+/1638N mouse (2010) (0)
Neuromuscu lar degenerat ion ( nmd ) : a mutat ion on mouse (2004) (0)
Abstract 12827: Mouse Model of LEOPARD Syndrome Reveals a Dominant Negative Function of the PTPN11 (Shp2) Mutation and a Mechanism of Regulation and Therapy for Hypertrophic Cardiomyopathy (2010) (0)
NF1 deficiency correlates with estrogen receptor signaling and diminished survival in breast cancer (2018) (0)
p 73-deficientmicehaveneurological , pheromonal and inflammatory defectsbutlackspontaneoustumours (0)
MyD88 Intrinsically Regulates CD4 T-Cell Responses (cid:1) (2009) (0)
Roscovitine Prevents Alloreactive T Cell Expansion and TNF-a-Mediated Proinflammatory Gene Expression and Protects against GvHD. (2008) (0)
513 HLA-DR*405 Transgenic NOD Mice Develop Autoimmune Pancreatitis (2008) (0)
Using Infant Rabbits Back to the Future : Studying Cholera Pathogenesis 2010 (2010) (0)
Merkel cell polyomavirus T antigen expression in murine skin 1 Title : Tumorigenic activity of Merkel cell polyomavirus T antigens expressed in the stratified epithelium of mice Running (2015) (0)
Animal Cytogenetics and Comparative Mapping (2001) (0)
Publisher Correction: Keap1 mutation renders lung adenocarcinomas dependent on Slc33a1 (2020) (0)
Molecule HLA-DQ 8 Myocarditis Using the Human MHC A Spontaneous Model for Autoimmune (2004) (0)
A PDGFRα-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine (2018) (0)
FOXO protects against age# progressive axonal degeneration The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters (2018) (0)
Abstract P3-05-05: Class IIa HDAC inhibition promotes an anti-tumor macrophage phenotype that induces breast tumor regression and inhibits metastasis (2018) (0)
Correction: Stochastic Model of Tsc1 Lesions in Mouse Brain (2013) (0)
Abstract LB-430: Chemopreventive effect of beta-cryptoxanthin on smoke-induced lung inflammation and lesions in ferrets (2010) (0)
Protein Truncated Species of Retinoblastoma Tumor Suppression by a Severely (2002) (0)
Abstract 3300: Cancer stem cell heterogeneity and cell-of-origin in medulloblastomas (2012) (0)
Isoform-specific deletion of PKM2 constrains tumor initiation in a mouse model of soft tissue sarcoma (2018) (0)
Dooley 1 Nuclear Factor I / B is an Oncogene in Small Cell Lung Cancer (2011) (0)
The Mouse Mutation “Thrombocytopenia and Cardiomyopathy” (trac) Is within the ABCG5 Gene: A Single Gene Model for Human Mediterranean Macrothrombocytopenia. (2007) (0)
Abstract A31: Biological effects of lutein and kale on the prevention of colonic inflammation and carcinogenesis (2017) (0)
Hereditary Progressive Ankylosis, Mouse (1991) (0)
Abstract 4447: Deep neural network for automatic histopathologic analysis of murine lung tumors (2019) (0)
A GATA4-regulated secretory program suppresses tumors through recruitment of cytotoxic CD8 T cells (2022) (0)
MHC polymorphism and diseases (WS-088) Chairpersons: Yasuharu Nishimura, Narinder Mehra (2010) (0)
Navitoclax enhances the effectiveness of EGFR-targeted antibody-drug conjugates in PDX models of EGFR-expressing triple-negative breast cancer (2020) (0)
Molecular and Cellular Pathobiology Chronic Activation of Wild-Type Epidermal Growth Factor Receptor and Loss of Cdkn 2 a Cause Mouse Glioblastoma Formation (2011) (0)
Organoid modeling reveals the tumorigenic potential of the alveolar progenitor cell state (2023) (0)
Computer-based animal record system in a nonhuman primate colony. (1981) (0)
Abstract A43: Loss of Keap1 promotes KRAS-driven lung cancer and results in genotype-specific vulnerabilities (2018) (0)
Aneuploidy as a driver of liver cancer (2015) (0)
Abstract P4-14-02: Neutralization of BCL2/BCL-XL enhances the cytotoxicity of T-DM1 in vivo (2016) (0)
Vaccine induced immunopathology mediated by memory CD4 T cells following chronic viral infection (VIR7P.1054) (2014) (0)
M.Aikawa, J.R.Broderson, I.Ikuo, G.Jakobs, M.Pappaioanou, W.E.Collins, and C.C.Campbell, An Atlas of Renal Disease in Aotus Monkeys with Experimental Plasmodial Infection. American Institute of Biological Sciences, Arlington, VA1988. (1990) (0)
PTLD In Miniature Swine Following Novel Low Intensity Conditioning For Haploidentical HCT: The MGH Experience (2010) (0)
A GATA4-regulated secretory program suppresses tumors through recruitment of cytotoxic CD8 T cells (2022) (0)
Abstract 198: Aberrant Endothelial-myocardial Crosstalk Causes Hypertrophy in Noonan Syndrome With Multiple Lentigines (2015) (0)
Abstract P023: Mismatch repair deficiency is not sufficient to increase tumor immunogenicity (2022) (0)
Tumor and Stem Cell Biology EpigeneticStatesofCells ofOrigin andTumorEvolutionDrive Tumor-Initiating Cell Phenotype and Tumor Heterogeneity (2014) (0)
Central Nervous System Cycle Defects without Apoptosis in the Causes Cell Rb Conditional Mutation of (2003) (0)
Dystrophic Muscle in Mice Chimeric for Expression of (cid:97) 5 Integrin (1998) (0)
tumor progression in a mouse model of lung cancer Chronic cisplatin treatment promotes enhanced damage repair and Material (2010) (0)
Abstract 2367: Neural progenitor cells deficient in BAX and BAK manifest progressive hyperplasia and tumorigenesis (2012) (0)
Abstract B43: NF1 deficiency induces aggressive mammary carcinomas in a CRISPR rat model and correlates with poor outcome in sporadic human breast cancer (2018) (0)
647 Concomitant BRAF and PI3K/mTOR Blockade is Required for Effective Treatment of BRAFV600E Colon Cancer (2012) (0)
An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer (2018) (0)
CD11c DCs Accelerate the Rejection of Older Cardiac Transplants via IL-17A Running title: Oberhuber et al.; Aged DCs augment cardiac allograft rejection (2019) (0)
Author response: Deletion of the MAD2L1 spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell lymphoma and hepatocellular carcinoma (2017) (0)
Aag DNA Glycosylase Promotes Alkylation-Induced Tissue Damage Mediated by Parp 1 Citation (2013) (0)
Abstract 196: Adult-onset Cardiac Hypertrophy In LEOPARD Syndrome Is Caused By Both Cell Autonomous And Non-autonomous Effects That Occur During Development (2013) (0)
Biochemical and Molecular Roles of Nutrients Dietary Supplementation with Mushroom-Derived Protein-Bound Glucan Does Not Enhance Immune Function in Young and Old Mice (1998) (0)
Tumor and Stem Cell Biology Genetic Ablation of Metadherin Inhibits Autochthonous Prostate Cancer Progression and Metastasis (2014) (0)
Genetic Ablation of (cid:1) v Integrins in Epithelial Cells of the Eyelid Skin and Conjunctiva Leads to Squamous Cell Carcinoma (2008) (0)
Mlh1 as a tumor suppressor of skin (2007) (0)
Epstein-Barr Virus Nuclear Antigen 1 Does Not Cause Lymphoma in C57BL/6J Mice (cid:1) (2008) (0)

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