Roger M. Perlmutter | Academic Influence

Why Is Roger M. Perlmutter Influential?

According to Wikipedia, Roger M. Perlmutter is the former executive vice president of Merck & Co. and former president of Merck Research Laboratories. He is currently a non-executive director of Merck Research Laboratories.

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Roger M. Perlmutter's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

A Syndrome of Multiorgan Hyperplasia with Features of Gigantism, Tumorigenesis, and Female Sterility in p27 Kip1 -Deficient Mice (1996) (1610)
Interaction of the unique N-terminal region of tyrosine kinase p56 lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs (1990) (634)
Early restriction of the human antibody repertoire. (1987) (556)
Defective T cell receptor signaling in mice lacking the thymic isoform of p59 fyn (1992) (507)
A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA (1985) (459)
Selective requirement for MAP kinase activation in thymocyte differentiation (1995) (445)
Subclass restriction of murine anti-carbohydrate antibodies. (1978) (420)
CD22 regulates thymus-independent responses and the lifespan of B cells (1996) (414)
Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation (1995) (402)
Impaired expansion of mouse B cell progenitors lacking Btk. (1995) (340)
Developmentally controlled expression of immunoglobulin VH genes. (1985) (331)
A dominant‐negative transgene defines a role for p56lck in thymopoiesis. (1993) (319)
Involvement of p21ras distinguishes positive and negative selection in thymocytes. (1995) (310)
Activation of the Raf-1 kinase cascade by coumermycin-induced dimerization (1996) (309)
Differential signaling by lymphocyte antigen receptors. (1997) (300)
Positive and negative selection invoke distinct signaling pathways (1996) (291)
Thymic stromal lymphopoietin: a cytokine that promotes the development of IgM+ B cells in vitro and signals via a novel mechanism. (1999) (251)
Dissection of thymocyte signaling pathways by in vivo expression of pertussis toxin ADP‐ribosyltransferase. (1990) (250)
Fyn can partially substitute for Lck in T lymphocyte development. (1996) (235)
Novel protein-tyrosine kinase gene (hck) preferentially expressed in cells of hematopoietic origin (1987) (230)
T cell antigen receptor-mediated activation of the Ras/mitogen-activated protein kinase pathway controls interleukin 4 receptor function and type-2 helper T cell differentiation. (1999) (228)
The impact of systems approaches on biological problems in drug discovery (2004) (228)
Neoplastic transformation induced by an activated lymphocyte-specific protein tyrosine kinase (pp56lck) (1988) (204)
Regulation of lymphocyte function by protein phosphorylation. (1993) (202)
Evidence for selection of a population of multi-reactive B cells into the splenic marginal zone. (1997) (189)
Structure and evolution of mammalian VH families. (1990) (176)
Inhibition of T‐cell receptor beta‐chain gene rearrangement by overexpression of the non‐receptor protein tyrosine kinase p56lck. (1992) (173)
An activated lck transgene promotes thymocyte development in RAG-1 mutant mice. (1994) (173)
Control of B cell development by Ras‐mediated activation of Raf (1997) (170)
Thymic tumorigenesis induced by overexpression of p56lck. (1991) (162)
Presenilin-dependent γ-secretase activity modulates thymocyte development (2001) (157)
A pertussis toxin‐sensitive process controls thymocyte emigration (1991) (155)
Translational activation of the lck proto-oncogene (1988) (154)
The generation of diversity in phosphorylcholine-binding antibodies. (1984) (152)
Control of B cell production by the adaptor protein lnk. Definition Of a conserved family of signal-modulating proteins. (2000) (143)
Developmental regulation of lck gene expression in T lymphocytes (1991) (133)
Functional dissection of the lck proximal promoter (1992) (131)
Delayed thymocyte development induced by augmented expression of p56lck (1991) (126)
Protein tyrosine kinase p56lck controls allelic exclusion of T-cell receptor β-chain genes (1993) (126)
Immunoglobulin subclass-specific immunodeficiency in mice with an X- linked B-lymphocyte defect (1979) (123)
Functional coupling of the src-family protein tyrosine kinases p59fyn and p53/56lyn with the interleukin 2 receptor: implications for redundancy and pleiotropism in cytokine signal transduction. (1993) (114)
Hematopoietic Progenitor Kinase 1 Associates Physically and Functionally with the Adaptor Proteins B Cell Linker Protein and SLP-76 in Lymphocytes* (2001) (112)
Restoration of Thymopoiesis in pTα−/− Mice by Anti-CD3ε Antibody Treatment or with Transgenes Encoding Activated Lck or Tailless pTα (1997) (107)
Regulation of pp56lck during T‐cell activation: functional implications for the src‐like protein tyrosine kinases. (1987) (105)
The CD11b promoter directs high-level expression of reporter genes in macrophages in transgenic mice. (1995) (102)
Lymphocyte activation provokes modification of a lymphocyte-specific protein tyrosine kinase (p56lck). (1989) (101)
Augmented expression of a myeloid-specific protein tyrosine kinase gene (hck) after macrophage activation (1988) (99)
Expression of a novel form of the fyn proto-oncogene in hematopoietic cells. (1989) (94)
Caspase Enzyme Activity Is Not Essential for Apoptosis During Thymocyte Development1 (2000) (94)
Disruption of thymocyte development and lymphomagenesis induced by SV40 T-antigen. (1990) (92)
Localization of a lymphocyte-specific protein tyrosine kinase gene (lck) at a site of frequent chromosomal abnormalities in human lymphomas. (1986) (90)
A signaling pathway governing early thymocyte maturation. (1995) (87)
Participation of CD4 coreceptor molecules in T-cell repertoire selection (1991) (87)
Interleukin 4 expressed in situ selectively alters thymocyte development (1991) (85)
Structure and expression of Ick transcripts in human lymphoid cells (1988) (82)
Specialized protein tyrosine kinase proto-oncogenes in hematopoietic cells. (1989) (82)
Expression of the p56lckY505F Mutation in CD45-Deficient Mice Rescues Thymocyte Development (1999) (81)
Involvement of the protein tyrosine kinase p56lck in T cell signaling and thymocyte development. (1994) (80)
Requirement for p56lck tyrosine kinase activation in T cell receptor- mediated thymic selection (1996) (80)
Regulation of L-Selectin–mediated Rolling through Receptor Dimerization (1998) (73)
Functional dissection of the murine lck distal promoter. (1995) (70)
Structure of the murine lck gene and its rearrangement in a murine lymphoma cell line (1988) (69)
Involvement of p59fynT in interleukin-5 receptor signaling [published erratum appears in J Exp Med 1995 Oct 1;182(4):1179] (1995) (62)
Disruption of CD8‐dependent negative and positive selection of thymocytes is correlated with a decreased association between CD8 and the protein tyrosine kinase, p56lck (1992) (61)
Diversity in the germline antibody repertoire. Molecular evolution of the T15 VN gene family (1985) (58)
Characterization of Lnk (1997) (58)
Heterogeneity in the human Ig VH locus. (1989) (57)
Impaired Lymphopoiesis and Altered B Cell Subpopulations in Mice Overexpressing Lnk Adaptor Protein (2003) (53)
Expression of the c-fgr and hck protein-tyrosine kinases in acute myeloid leukemic blasts is associated with early commitment and differentiation events in the monocytic and granulocytic lineages. (1991) (53)
Ig heavy chain variable region gene complex of lupus mice exhibits normal restriction fragment length polymorphism (1985) (50)
Presenilin-dependent gamma-secretase activity modulates thymocyte development. (2001) (48)
Requirement for Jak3 in mature T cells: its role in regulation of T cell homeostasis. (1998) (48)
Multiple VH gene segments encode murine antistreptococcal antibodies (1984) (45)
p56lck protein-tyrosine kinase is cytoskeletal and does not bind to polyomavirus middle T antigen (1988) (41)
Activated p56lck Directs Maturation of Both CD4 and CD8 Single-Positive Thymocytes1 (2001) (41)
Functional dissection of p56lck, a protein tyrosine kinase which mediates interleukin-2-induced activation of the c-fos gene (1994) (40)
Differential contribution of Lck and Fyn protein tyrosine kinases to intraepithelial lymphocyte development (1997) (39)
Identification and Characterization of a Transcriptional Regulator for the lck Proximal Promoter* (2001) (37)
T cell signaling. (1989) (35)
Intestinal intraepithelial lymphocytes include precursors committed to the T cell receptor αβ lineage (1998) (34)
Control of lymphopoiesis by p50csk, a regulatory protein tyrosine kinase (1995) (34)
Structure and expression of lck transcripts in human lymphoid cells. (1988) (34)
Selective expression of alternative lck mRNAs in human malignant cell lines (1989) (34)
Replacement of Pre-T Cell Receptor Signaling Functions by the CD4 Coreceptor (1997) (33)
Complete sharing of light chain spectrotypes by murine IgM and IgG anti-streptococcal antibodies. (1977) (33)
Restoration of thymopoiesis in pT alpha-/- mice by anti-CD3epsilon antibody treatment or with transgenes encoding activated Lck or tailless pT alpha. (1997) (31)
Analysis of the diversity of murine antibodies to dextran B1355. III. Idiotypic and spectrotypic correlations (1978) (30)
Immunologic memory to phosphocholine. IV. Hybridomas representative of Group I (T15-like) and Group II (non-T15-like) antibodies utilize distinct VH genes. (1984) (30)
Transformation of NIH 3T3 fibroblasts by an activated form of p59hck (1989) (30)
Streptococcal group A carbohydrate has properties of both a thymus-independent (TI-2) and a thymus-dependent antigen. (1982) (27)
Expression of lineage‐restricted protein tyrosine kinase genes in human natural killer cells (1991) (27)
Programmed development of the antibody repertoire. (1987) (26)
A novel 6:10 chromosomal translocation in the murine plasmacytoma NS-1 (1984) (25)
Coumermycin-induced dimerization of GyrB-containing fusion proteins. (2000) (24)
The protein tyrosine kinase p56lck regulates thymocyte development independently of its interaction with CD4 and CD8 coreceptors [corrected] [published erratum appears in J Exp Med 1993 Sep 1;178(3):1135] (1993) (24)
CD8 inhibits signal transduction through the T cell receptor in CD4-CD8- thymocytes from T cell receptor transgenic mice reconstituted with a transgenic CD8 alpha molecule. (1993) (24)
Decreased signaling competence as a result of receptor overexpression: overexpression of CD4 reduces its ability to activate p56lck tyrosine kinase and to regulate T-cell antigen receptor expression in immature CD4+CD8+ thymocytes. (1993) (24)
Cell type and developmental regulation of the fyn proto-oncogene in neural retina. (1992) (23)
A Mechanism Misregulating p27 in Tumors Discovered in a Functional Genomic Screen (2007) (23)
Molecular heterogeneity and fine specificity of BALB/c antibodies elicited by isologous myeloma protein (1978) (19)
The use of dominant-negative mutations to elucidate signal transduction pathways in lymphocytes. (1996) (19)
Autoantibodies and the fetal antibody repertoire. (1990) (17)
Insulin-specific murine antibodies of limited heterogeneity. I. Genetic control of spectrotypes. (1979) (17)
Protein tyrosine kinase p56lck controls allelic exclusion of T-cell receptor beta-chain genes. (1993) (16)
Membrane Localization of Raf Assists Engagement of Downstream Effectors* (2000) (15)
Immunologic memory to phosphocholine. V. Hybridomas representative of group II antibodies utilize V kappa 1-3 gene(s). (1984) (15)
Aspartic Proteinases (1995) (14)
Immune response deficiency of BSVS mice. II. Generalized deficiency to thymus‐dependent antigens (1979) (14)
Characterization of molecular heterogeneity and multispecificity in homologous idiotypic antisera. (1977) (13)
Structure of the Murine Ick Gene and Its Rearrangement in a Murine Lymphoma Cell Line (9)
Intestinal intraepithelial lymphocytes include precursors committed to the T cell receptor alpha beta lineage. (1998) (9)
Light chain diversity of murine anti-streptococcal antibodies: IgCH-linked effects on L chain expression. (1978) (9)
Control of T cell development by non-receptor protein tyrosine kinases. (1995) (8)
Analysis of the role of MKK-4/Sek-1 in T cell development and apoptosis. (1998) (8)
Molecular dissection of the murine antibody response to streptococcal group A carbohydrate (1987) (8)
Molecular Dissection of Lymphocyte Signal Transduction Pathways (1993) (7)
Zapping T-cell responses (1994) (7)
Erratum: The protein tyrosine p56(lck) regulates thymocyte development independently of its interaction with CD4 and CD8 coreceptors (The Journal of Experimental Medicine (July 1993) 178 (1)) (1993) (7)
In vivo dissection of lymphocyte signaling pathways. (1993) (7)
The Molecular Genetics of Phosphocholine-Binding Antibodies (1984) (7)
Analysis of the Diversity of Murine Antibodies to α(1→3)Dextran (1979) (6)
Differential involvement of protein tyrosine kinases p56lck and p59fyn in T cell development. (1992) (6)
Effect of Hydrogen Peroxide and Heat on Some Characteristics of B-Lactoglobulin (1972) (5)
Thymic tumorigenesis induced by overexpression of p 56 lck ( tyrosine kinases / oncogenesis / transgenic mice ) (5)
Molecular genetics of anti-carbohydrate antibodies. (1984) (4)
Molecular Dissection of Lymphocyte Signal Transduction Pathways (1993) (3)
Structure and expression of the murine hck gene. (1991) (3)
Amgen's point of view on epoetins. (2004) (3)
Functional Dissection of the Ick Proximal Promoter (2)
Replacement of PreT Cell Receptor Signaling Functions by the CD 4 Coreceptor (1996) (2)
Translational regulation of the lymphocyte-specific protein tyrosine kinase p56lck. (1990) (2)
Differential effects of manipulating signaling in early T cell development in intestinal intraepithelial lymphocytes and thymocytes. (1999) (2)
The Protein Tyrosine p 56 tc ~ Regulates Thymocyte Development Independently of Its Interaction with CD 4 and CD 8 Coreceptors (2003) (2)
CD 4 and CD 8 Single-Positive Thymocytes Directs Maturation of Both lck Activated p 56 (2001) (2)
Organization and Reorganization of Antigen Receptor Genes (1989) (2)
Functional Dissection oftheIckProximal Promoter (1992) (2)
Roger Perlmutter on shaping Amgen's R&D strategy. Interview by Christopher Watson. (2005) (1)
Chapter 21 Portooncogene Expression following Lymphocyte Activation (1990) (1)
Control of lymphopoiesis by non-receptor protein tyrosine kinases. (1994) (1)
AACR Annual Meeting 2014 (2014) (1)
Immunodeficiency. Zapping T-cell responses. (1994) (1)
- Lck: Lck protein-tyrosine kinase (vertebrates) (p56lck) (1995) (0)
Control of Lymphopoiesis by p 50 ' ~ ' , a Regulatory Protein Tyrosine Kinase (2003) (0)
This information is current as Apoptosis During Thymocyte Development Caspase Enzyme Activity Is Not Essential for Perlmutter (2000) (0)
T cell antigen receptor-mediated activation of the Ras y mitogen-activated protein kinase pathway controls interleukin 4 receptor function and type-2 helper T cell differentiation (1999) (0)
Molecular heterogeneity and fine specificity of isologous antibodies induced by the dnp-binding iga (m315) of mopc-315. Abstr. (1978) (0)
Yes: Yes protein-tyrosin kinase (vertehrates) (p62c-ves) (1995) (0)
MechanismCells In Vitro and Signals Via a Novel B + That Promotes the Development of IgM Thymic Stromal Lymphopoietin: A Cytokine (1998) (0)
Editorial Board (1995) (0)
Insulin-Specific Murine Antibodies of Limited Heterogeneity (1979) (0)
Fgr: Fgr protein-tyrosine kinase (vertebrates) (p59fgr) (1995) (0)
Interleukin-4 transgenic mice: A novel animal model for osteoporosis (1992) (0)
Editorial Board (1995) (0)
Hck: Hck protein-tyrosine kinase (vertebrates) (p59hck) (1995) (0)
Non-Receptor Protein Tyrosine Kinases (1995) (0)
Subpopulations in Mice Overexpressing Lnk Impaired Lymphopoiesis and Altered B Cell (2002) (0)
- Lyn: Lyn protein-tyrosine kinase (vertebrates) (p53/56lyn) (1995) (0)
Molecular dissection of lymphocyte signal transduction pathways. Discussion (1993) (0)
Editorial Board (1995) (0)
Correction (1995) (0)
Strain-specific variation in the t15 gene family at the dna level. Abstr. (1982) (0)

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