Roland Kanaar
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Psychology Biology
Roland Kanaar's Degrees
- PhD Psychology University of Amsterdam
- Masters Cognitive Neuroscience University of Amsterdam
- Bachelors Psychology University of Amsterdam
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(Suggest an Edit or Addition)Roland Kanaar's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Chromosomal stability and the DNA double-stranded break connection (2001) (1255)
- DNA double-strand break repair: all's well that ends well. (2006) (796)
- Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells (2001) (589)
- Molecular mechanisms of DNA double strand break repair. (1998) (560)
- Repair of DNA interstrand cross-links. (2001) (554)
- Human Rad50/Mre11 is a flexible complex that can tether DNA ends. (2001) (523)
- The Structure-Specific Endonuclease Ercc1-Xpf Is Required To Resolve DNA Interstrand Cross-Link-Induced Double-Strand Breaks (2004) (491)
- Dynamics of DNA Double-Strand Breaks Revealed by Clustering of Damaged Chromosome Domains (2004) (478)
- Disruption of Mouse RAD54 Reduces Ionizing Radiation Resistance and Homologous Recombination (1997) (463)
- Nuclear Dynamics of PCNA in DNA Replication and Repair (2005) (409)
- The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaks (2007) (399)
- ATP-Dependent Chromatin Remodeling by the Cockayne Syndrome B DNA Repair-Transcription-Coupling Factor (2000) (365)
- Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaks. (2011) (356)
- Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair. (2009) (349)
- The structure‐specific endonuclease Mus81–Eme1 promotes conversion of interstrand DNA crosslinks into double‐strands breaks (2006) (303)
- Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition (2011) (301)
- The Rad51 Paralog Rad51B Promotes Homologous Recombinational Repair (2000) (281)
- Nuclear dynamics of RAD52 group homologous recombination proteins in response to DNA damage (2002) (279)
- Mesoscale conformational changes in the DNA-repair complex Rad50/Mre11/Nbs1 upon binding DNA (2005) (279)
- Brca2 (XRCC11) Deficiency Results in Radioresistant DNA Synthesis and a Higher Frequency of Spontaneous Deletions (2002) (258)
- Homologous and non‐homologous recombination differentially affect DNA damage repair in mice (2000) (255)
- Rec8p, a Meiotic Recombination and Sister Chromatid Cohesion Phosphoprotein of the Rad21p Family Conserved from Fission Yeast to Humans (1999) (252)
- Mesenchymal Inflammation Drives Genotoxic Stress in Hematopoietic Stem Cells and Predicts Disease Evolution in Human Pre-leukemia. (2016) (251)
- Evidence for Replicative Repair of DNA Double-Strand Breaks Leading to Oncogenic Translocation and Gene Amplification (2002) (235)
- Mouse Rad54 affects DNA conformation and DNA-damage-induced Rad51 foci formation (1999) (225)
- Homologous recombination-mediated double-strand break repair. (2004) (212)
- CTG repeat instability and size variation timing in DNA repair‐deficient mice (2003) (203)
- Involvement of Mammalian Mus81 in Genome Integrity and Tumor Suppression (2004) (199)
- Mouse RAD54 Affects DNA Double-Strand Break Repair and Sister Chromatid Exchange (2000) (188)
- Activation of multiple DNA repair pathways by sub-nuclear damage induction methods (2007) (175)
- Counting RAD51 proteins disassembling from nucleoprotein filaments under tension (2008) (167)
- The structure‐specific endonuclease Ercc1—Xpf is required for targeted gene replacement in embryonic stem cells (2001) (167)
- Transcriptome analysis reveals cyclobutane pyrimidine dimers as a major source of UV‐induced DNA breaks (2005) (164)
- Perturbations of Vascular Homeostasis and Aortic Valve Abnormalities in Fibulin-4 Deficient Mice (2007) (164)
- Mammalian Rad51C contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability. (2002) (160)
- Collaboration of homologous recombination and nonhomologous end-joining factors for the survival and integrity of mice and cells. (2004) (156)
- Regulation of DNA strand exchange in homologous recombination. (2010) (155)
- Human and mouse homologs of the Saccharomyces cerevisiae RAD54 DNA repair gene: evidence for functional conservation (1996) (155)
- XPF-ERCC1 Participates in the Fanconi Anemia Pathway of Cross-Link Repair (2009) (152)
- Single-molecule manipulation of double-stranded DNA using optical tweezers: interaction studies of DNA with RecA and YOYO-1. (1999) (150)
- Experimental Evidence for Enhanced Receptor Binding by Rapidly Spreading SARS-CoV-2 Variants (2021) (148)
- Rad54, a Jack of all trades in homologous recombination. (2003) (148)
- The Human Rad54 Recombinational DNA Repair Protein Is a Double-stranded DNA-dependent ATPase* (1998) (145)
- Disruption of maternal DNA repair increases sperm-derived chromosomal aberrations (2007) (145)
- The architecture of the human Rad54–DNA complex provides evidence for protein translocation along DNA (2001) (144)
- Differential Contributions of Mammalian Rad54 Paralogs to Recombination, DNA Damage Repair, and Meiosis (2006) (142)
- Eme1 is involved in DNA damage processing and maintenance of genomic stability in mammalian cells (2003) (139)
- DNA repair: Spot(light)s on chromatin (2001) (139)
- Human Rad51 filaments on double- and single-stranded DNA: correlating regular and irregular forms with recombination function (2005) (135)
- Functional Ex Vivo Assay to Select Homologous Recombination–Deficient Breast Tumors for PARP Inhibitor Treatment (2014) (135)
- Rad54 and DNA Ligase IV cooperate to maintain mammalian chromatid stability. (2004) (133)
- Mechanisms of Dealing with DNA Damage-Induced Replication Problems (2008) (133)
- Disruption of Mouse SNM1 Causes Increased Sensitivity to the DNA Interstrand Cross-Linking Agent Mitomycin C (2000) (133)
- DNA-binding and strand-annealing activities of human Mre11: implications for its roles in DNA double-strand break repair pathways. (2001) (129)
- Processive recombination by the phage Mu Gin system: Implications for the mechanisms of DNA strand exchange, DNA site alignment, and enhancer action (1990) (129)
- Chromatin mobility is increased at sites of DNA double-strand breaks (2012) (128)
- Regulation of tissue-specific P-element pre-mRNA splicing requires the RNA-binding protein PSI. (1994) (125)
- A novel Fanconi anaemia subtype associated with a dominant-negative mutation in RAD51 (2015) (120)
- Dealing with DNA damage: relationships between checkpoint and repair pathways. (2010) (118)
- Real-time assembly and disassembly of human RAD51 filaments on individual DNA molecules (2007) (113)
- The CSB Protein Actively Wraps DNA* (2005) (112)
- DNA double-strand break repair and chromosome translocations. (2006) (109)
- Tumor slice culture system to assess drug response of primary breast cancer (2016) (108)
- Architecture of a polycomb nucleoprotein complex. (2006) (107)
- RAD51AP1 is a structure-specific DNA binding protein that stimulates joint molecule formation during RAD51-mediated homologous recombination. (2007) (106)
- Homologous recombination in real time: DNA strand exchange by RecA. (2008) (97)
- Roles of supercoiled DNA structure in DNA transactions (1992) (96)
- The conserved pre-mRNA splicing factor U2AF from Drosophila: requirement for viability. (1993) (93)
- Hyperthermia-induced DNA repair deficiency suggests novel therapeutic anti-cancer strategies (2012) (92)
- Analysis of mouse Rad54 expression and its implications for homologous recombination. (2002) (92)
- The coiled-coil of the human Rad50 DNA repair protein contains specific segments of increased flexibility (2003) (91)
- Improving efficacy of hyperthermia in oncology by exploiting biological mechanisms (2016) (90)
- Inactivation of Pol θ and C-NHEJ eliminates off-target integration of exogenous DNA (2017) (88)
- Processive recombination by wild-type gin and an enhancer-independent mutant. Insight into the mechanisms of recombination selectivity and strand exchange. (1994) (87)
- Sequence conservation of the rad21 Schizosaccharomyces pombe DNA double-strand break repair gene in human and mouse. (1996) (87)
- Hallmarks of hyperthermia in driving the future of clinical hyperthermia as targeted therapy: translation into clinical application (2016) (85)
- Analysis of ionizing radiation-induced foci of DNA damage repair proteins. (2005) (85)
- Fluorescent human RAD51 reveals multiple nucleation sites and filament segments tightly associated along a single DNA molecule. (2007) (83)
- Dynamics of RecA filaments on single-stranded DNA (2009) (82)
- Genome editing by natural and engineered CRISPR-associated nucleases (2018) (81)
- Tetramerization and DNA ligase IV interaction of the DNA double-strand break repair protein XRCC4 are mutually exclusive. (2003) (80)
- ATP-dependent and independent functions of Rad54 in genome maintenance (2011) (80)
- Mutations in the small subunit of the Drosophila U2AF splicing factor cause lethality and developmental defects. (1996) (79)
- Suppression of retroviral infection by the RAD52 DNA repair protein (2004) (78)
- Interaction of the sex‐lethal RNA binding domains with RNA. (1995) (78)
- Analysis of DNA double-strand break repair pathways in mice. (2007) (75)
- Mutations in the hrp48 gene, which encodes a Drosophila heterogeneous nuclear ribonucleoprotein particle protein, cause lethality and developmental defects and affect P-element third-intron splicing in vivo (1997) (73)
- Induction of linear tracks of DNA double-strand breaks by α-particle irradiation of cells (2008) (72)
- Analysis of strand exchange and DNA binding of enhancer‐independent Gin recombinase mutants. (1993) (71)
- DNA end-binding specificity of human Rad50/Mre11 is influenced by ATP. (2002) (70)
- Quality control of DNA break metabolism: in the ‘end’, it's a good thing (2008) (69)
- Mutation of the mouse Rad17 gene leads to embryonic lethality and reveals a role in DNA damage‐dependent recombination (2004) (68)
- Characteristics of DNA-binding proteins determine the biological sensitivity to high-linear energy transfer radiation (2010) (68)
- Mismatch repair and homeologous recombination. (2016) (67)
- Dynamics of relative chromosome position during the cell cycle. (2004) (65)
- Involvement of the nuclear proteasome activator PA28γ in the cellular response to DNA double-strand breaks (2011) (65)
- RAD50 and NBS1 form a stable complex functional in DNA binding and tethering (2009) (65)
- Ionizing radiation-induced foci formation of mammalian Rad51 and Rad54 depends on the Rad51 paralogs, but not on Rad52. (2005) (64)
- Dissecting elastic heterogeneity along DNA molecules coated partly with Rad51 using concurrent fluorescence microscopy and optical tweezers. (2006) (63)
- Recombination and joining: different means to the same ends. (1997) (62)
- Rad52 and Ku bind to different DNA structures produced early in double-strand break repair. (2003) (61)
- Differential arrangements of conserved building blocks among homologs of the Rad50/Mre11 DNA repair protein complex. (2004) (60)
- Mediators of homologous DNA pairing. (2014) (60)
- Interaction between Subunits of Heterodimeric Splicing Factor U2AF Is Essential In Vivo (1998) (57)
- Activation of the SUMO modification system is required for the accumulation of RAD51 at sites of DNA damage (2013) (57)
- Absence of interdomain contacts in the crystal structure of the RNA recognition motifs of Sex-lethal. (1999) (56)
- Gin-mediated DNA inversion: product structure and the mechanism of strand exchange. (1988) (56)
- BRCA2 diffuses as oligomeric clusters with RAD51 and changes mobility after DNA damage in live cells (2014) (54)
- Contributions of supercoiling to Tn3 resolvase and phage Mu Gin site-specific recombination. (1996) (52)
- Resonance assignments and solution structure of the second RNA-binding domain of sex-lethal determined by multidimensional heteronuclear magnetic resonance. (1994) (50)
- Torque-limited RecA polymerization on dsDNA (2005) (49)
- Inhibition of homologous recombination by hyperthermia shunts early double strand break repair to non-homologous end-joining. (2013) (48)
- Corrigendum to “Rad54, a Jack of all trades in homologous recombination” [DNA Repair 2 (2003) 787–794] (2003) (47)
- Homologous Recombination: Down to the Wire (2004) (46)
- Functional Ex Vivo Assay Reveals Homologous Recombination Deficiency in Breast Cancer Beyond BRCA Gene Defects (2018) (46)
- Mismatch repair inhibits homeologous recombination via coordinated directional unwinding of trapped DNA structures. (2013) (45)
- Gin-mediated recombination of catenated and knotted DNA substrates: Implications for the mechanism of interaction between cis-acting sites (1989) (44)
- Torsional regulation of hRPA-induced unwinding of double-stranded DNA (2010) (43)
- Decreased mitochondrial respiration in aneurysmal aortas of Fibulin-4 mutant mice is linked to PGC1A regulation (2018) (43)
- Chemical shift mapping of the RNA-binding interface of the multiple-RBD protein sex-lethal. (1997) (43)
- ATR and Rad17 collaborate in modulating Rad9 localisation at sites of DNA damage (2008) (42)
- The effect of thermal dose on hyperthermia-mediated inhibition of DNA repair through homologous recombination (2017) (42)
- DNA Repair by the MRN Complex: Break It to Make It (2008) (41)
- Architectural plasticity of human BRCA2–RAD51 complexes in DNA break repair (2017) (40)
- Visualizing RAD51-mediated joint molecules: implications for recombination mechanism and the effect of sequence heterology (2010) (40)
- Targeting homologous recombination-mediated DNA repair in cancer (2014) (39)
- RNA Binding Activity of Heterodimeric Splicing Factor U2AF: at Least One RS Domain Is Required for High-Affinity Binding (1998) (38)
- Genetic recombination: From competition to collaboration (1998) (37)
- Homologous recombination: from model organisms to human disease (2001) (37)
- BLM has early and late functions in homologous recombination repair in mouse embryonic stem cells (2010) (37)
- DNA damage response and anti-apoptotic proteins predict radiosensitization efficacy of HDAC inhibitors SAHA and LBH589 in patient-derived glioblastoma cells. (2015) (35)
- DNA damage induced Pol η recruitment takes place independently of the cell cycle phase (2009) (35)
- HSF2BP Interacts with a Conserved Domain of BRCA2 and Is Required for Mouse Spermatogenesis. (2019) (34)
- Analysis of DNA recombination and repair proteins in living cells by photobleaching microscopy. (2006) (34)
- Structure-specific endonucleases xpf and mus81 play overlapping but essential roles in DNA repair by homologous recombination. (2013) (33)
- Combined optical and topographic imaging reveals different arrangements of human RAD54 with presynaptic and postsynaptic RAD51–DNA filaments (2013) (32)
- DNA Damage-Inducing Anticancer Therapies: From Global to Precision Damage (2020) (31)
- Cell cycle-dependent processing of DNA lesions controls localization of Rad9 to sites of genotoxic stress (2009) (30)
- Comparison of High- and Low-LET Radiation-Induced DNA Double-Strand Break Processing in Living Cells (2020) (30)
- Defective Connective Tissue Remodeling in Smad3 Mice Leads to Accelerated Aneurysmal Growth Through Disturbed Downstream TGF-β Signaling (2016) (28)
- Ex vivo treatment of prostate tumor tissue recapitulates in vivo therapy response (2018) (27)
- A genetic switch in vitro: DNA inversion by Gin protein of phage Mu. (1984) (25)
- The response of mammalian cells to UV-light reveals Rad54-dependent and independent pathways of homologous recombination. (2011) (23)
- Heat-induced BRCA2 degradation in human tumours provides rationale for hyperthermia-PARP-inhibitor combination therapies (2018) (23)
- Fibulin-4 deficiency increases TGF-β signalling in aortic smooth muscle cells due to elevated TGF-β2 levels (2015) (23)
- Caffeine suppresses homologous recombination through interference with RAD51-mediated joint molecule formation (2013) (22)
- Molecular recognition of DNA-protein complexes: a straightforward method combining scanning force and fluorescence microscopy. (2010) (22)
- Enhancing synthetic lethality of PARP-inhibitor and cisplatin in BRCA-proficient tumour cells with hyperthermia (2017) (21)
- Type I interferons as radiosensitisers for pancreatic cancer. (2011) (21)
- The unstructured linker arms of MutL enable GATC site incision beyond roadblocks during initiation of DNA mismatch repair (2018) (20)
- Boosting the effects of hyperthermia-based anticancer treatments by HSP90 inhibition (2017) (20)
- Quantitative analysis of radiation-induced DNA break repair in a cultured oral mucosal model. (2006) (19)
- Exploiting DNA repair defects for novel cancer therapies (2016) (19)
- Chromosome Organization: Reaching out to Embrace New Models (2002) (18)
- Analysis of the mobility of DNA double-strand break-containing chromosome domains in living mammalian cells. (2008) (18)
- Extracellular Matrix Defects in Aneurysmal Fibulin-4 Mice Predispose to Lung Emphysema (2014) (18)
- Chromosomal Organization: Mingling with the Neighbors (2006) (18)
- BRCA2 diffuses as oligomeric clusters with RAD51 and changes mobility after DNA damage in live cells (2014) (18)
- Rad54 is required for the normal development of male and female germ cells and contributes to the maintainance of their genome integrity after genotoxic stress (2013) (18)
- ATM Modulates the Loading of Recombination Proteins onto a Chromosomal Translocation Breakpoint Hotspot (2010) (18)
- The Sep1 strand exchange protein from Saccharomyces cerevisiae promotes a paranemic joint between homologous DNA molecules. (1994) (17)
- Multiple interlinked mechanisms to circumvent DNA replication roadblocks. (2006) (17)
- Sensitizing thermochemotherapy with a PARP1-inhibitor (2016) (17)
- Dual daughter strand incision is processive and increases the efficiency of DNA mismatch repair (2016) (16)
- Semi-quantitative proteomics of mammalian cells upon short-term exposure to non-ionizing electromagnetic fields (2017) (16)
- Hyperthermia adds to trabectedin effectiveness and thermal enhancement is associated with BRCA2 degradation and impairment of DNA homologous recombination repair (2016) (15)
- Recombination mechanisms; fortieth anniversary meeting of the Holliday model. (2004) (15)
- Genome instability and Rad50(S): subtle yet severe. (2002) (15)
- Mre11-Rad50 complex crystals suggest molecular calisthenics. (2011) (15)
- Differential Dynamics of ATR-Mediated Checkpoint Regulators (2010) (15)
- On the Mechanism of Hyperthermia-Induced BRCA2 Protein Degradation (2019) (15)
- From DNA end chemistry to cell-cycle response: the importance of structure, even when it's broken. (2008) (14)
- Effect of the BRCA2 CTRD domain on RAD51 filaments analyzed by an ensemble of single molecule techniques (2011) (14)
- Comment on "Direct and real-time visualization of the disassembly of a single RecA-DNA-ATPgammaS complex using AFM imaging in fluid". (2006) (14)
- Workshop on processing of DNA damage. (1996) (14)
- HSF2BP negatively regulates homologous recombination in DNA interstrand crosslink repair (2020) (14)
- Direct Ex Vivo Observation of Homologous Recombination Defect Reversal After DNA-Damaging Chemotherapy in Patients With Metastatic Breast Cancer. (2019) (13)
- Purification of the Gin recombination protein of Escherichia coli phage Mu and its host factor. (1986) (13)
- Fibulin-4 deficiency differentially affects cytoskeleton structure and dynamics as well as TGFβ signaling. (2019) (13)
- UV-induced G2 checkpoint depends on p38 MAPK and minimal activation of ATR-Chk1 pathway (2013) (12)
- The recombinational enhancer for DNA inversion functions independent of its orientation as a consequence of dyad symmetry in the Fis-DNA complex. (1989) (12)
- Somatic hypermutation does not require Rad54 and Rad54B‐mediated homologous recombination (2003) (12)
- Uptake and subcellular distribution of radiolabeled polymersomes for radiotherapy (2020) (12)
- Modulating the Heat Stress Response to Improve Hyperthermia-Based Anticancer Treatments (2021) (12)
- BRCTx Is a Novel, Highly Conserved RAD18-Interacting Protein (2005) (11)
- Opposite modifying effects of HR and NHEJ deficiency on cancer risk in Ptc1 heterozygous mouse cerebellum (2011) (11)
- In vivo Importance of Homologous Recombination DNA Repair for Mouse Neural Stem and Progenitor Cells (2012) (11)
- NBS1 cooperates with homologous recombination to counteract chromosome breakage during replication. (2009) (11)
- Attenuated XPC Expression Is Not Associated with Impaired DNA Repair in Bladder Cancer (2015) (10)
- Topological aspects of site‐specific DNA‐inversion (1987) (10)
- DNA Double Strand Break Repair Pathways in Response to Different Types of Ionizing Radiation (2021) (10)
- PIQMIe: a web server for semi-quantitative proteomics data management and analysis (2014) (9)
- Analysis of the relationships between ATM and the Rad54 paralogs involved in homologous recombination repair. (2009) (9)
- Gene Conversion-Like Sequence Transfers Between Transgenic Antibody V Genes Are Independent of RAD541 (2002) (9)
- Variation in RAD51 details a hub of functions: opportunities to advance cancer diagnosis and therapy. (2018) (8)
- A Microfluidic Cancer-on-Chip Platform Predicts Drug Response Using Organotypic Tumor Slice Culture (2021) (8)
- Optical Imaging of Tumor Response to Hyperbaric Oxygen Treatment and Irradiation in an Orthotopic Mouse Model of Head and Neck Squamous Cell Carcinoma (2015) (8)
- Ex vivo assays to predict enhanced chemosensitization by hyperthermia in urothelial cancer of the bladder (2018) (7)
- Distinct roles of ATM and ATR in the regulation of ARP8 phosphorylation to prevent chromosome translocations (2018) (6)
- Low dose ionizing radiation strongly stimulates insertional mutagenesis in a γH2AX dependent manner (2019) (6)
- DNA repair and malignant hematopoiesis (2004) (5)
- Biochemical and Cellular Aspects of Homologous Recombination (2005) (5)
- Large Field Alpha Irradiation Setup for Radiobiological Experiments (2019) (5)
- Microscopy-based single-cell proteomic profiling reveals heterogeneity in DNA damage response dynamics (2022) (4)
- A mRad51-GFP antimorphic allele affects homologous recombination and DNA damage sensitivity. (2015) (4)
- Role of BRCA2 DNA-binding and C-terminal domain in its mobility and conformation in DNA repair (2021) (4)
- Contributions of Supercoiling to Tn 3 Resolvase and Phage Mu Gin Site-specific Recombination (4)
- Functional RECAP (REpair CAPacity) assay identifies homologous recombination deficiency undetected by DNA-based BRCAness tests (2022) (4)
- BRCA2 binding through a cryptic repeated motif to HSF2BP oligomers does not impact meiotic recombination (2021) (4)
- Variation in RAD51 details a hub of functions: opportunities to advance cancer diagnosis and therapy (2018) (3)
- Mutations in the small subunit of the Drosophila U 2 AF splicing factor cause lethality and developmental defects ( fruit fly / pre-mRNA splicing / RNA-binding proteins / RS domains ) (2005) (3)
- Single-Molecule Dynamics and Localization of DNA Repair Proteins in Cells. (2018) (3)
- Role of BRCA2 DNA-binding and C-terminal domain on its mobility and conformation in DNA repair (2021) (3)
- A cryptic BRCA2 repeated motif binds to HSF2BP oligomers with no impact on meiotic recombination (2020) (3)
- Functional Ex Vivo Tissue-Based Chemotherapy Sensitivity Testing for Breast Cancer (2022) (2)
- Correction: Functional Ex Vivo Assay Reveals Homologous Recombination Deficiency in Breast Cancer Beyond BRCA Gene Defects (2019) (2)
- I11: Dynamics of DNA double-strand breaks revealed by clustering of damaged chromosome domains (2005) (2)
- EXPERIMENTAL THERAPEUTICS AND PHARMACOLOGY (2013) (2)
- Heat-shock (H-S) and trabectedin efficacy in human soft-tissue sarcoma (STS) cells in vitro. (2013) (1)
- Torsional Regulation of hRPA-induced Unwinding of Double Stranded DNA (2010) (1)
- Nicholas (Nick) R. Cozzarelli 1938–2006 (2006) (1)
- AFM tip-induced dissociation of RecA-dsDNA filaments (2007) (1)
- Interplay and Quality Control of DNA Damage Repair Mechanisms (2011) (1)
- The cell biology of homologous recombination (2007) (1)
- HSF2BP Negatively Regulates Homologous Recombination in DNA Interstrand Crosslink Repair in Human Cells by Direct Interaction With BRCA2 (2018) (1)
- Evaluation of the Heat Shock Protein 90 Inhibitor Ganetespib as a Sensitizer to Hyperthermia-Based Cancer Treatments (2022) (0)
- Mouse models of premature aging aimed at defining the role of DNA damage caused by the aging and intervention in a disease related to aging. (2005) (0)
- Role of the breast cancer susceptibility gene BRCA2 and other recombination genes in providing genome stability (2002) (0)
- HSP90-inhibitor Ganetesbip potentiates radiosensitizing and chemosensitizing effects of hyperthermia (2017) (0)
- Resolving RAD51 Filament Nucleation, Extension and Disassembly on ssDNA and dsDNA One Protein at a Time (2011) (0)
- Title Distinct roles of ATM and ATR in the regulation of ARP 8 phosphorylation to prevent chromosome translocations (2019) (0)
- Faculty Opinions recommendation of RAD51 variant proteins from human lung and kidney tumors exhibit DNA strand exchange defects. (2018) (0)
- Abstract 382: Reduced Mitochondrial Function and Metabolic Dysregulation in Aneurysmal Fibulin-4 Mice. (2015) (0)
- Annealing Helicase HARP: A Single Molecule Study (2011) (0)
- PO-442 Ex vivo prostate cancer culture system recapitulates in vivo response to androgen antagonist (2018) (0)
- Faculty Opinions recommendation of High-resolution structure of the presynaptic RAD51 filament on single-stranded DNA by electron cryo-microscopy. (2018) (0)
- Abstract 15787: Aorta Proteome Profiling Uncovers Enhanced Arterial Aging In Aneurismal Fibulin-4 Mutant Mice (2010) (0)
- DNA end-binding speci ® city of human Rad 50 / Mre 11 is in ̄ uenced by ATP (0)
- Role of early double-strand breaks dynamics in the formation of chromosome translocations and cell killing by ionizing radiation (2005) (0)
- Faculty Opinions recommendation of Novel insights into RAD51 activity and regulation during homologous recombination and DNA replication. (2018) (0)
- Abstract 5543: DNA damage response and anti-apoptotic proteins are predictors of histone deacetylase inhibitors-mediated radiosensitization of glioblastoma (2014) (0)
- Repair of double strand breaks and cross-links in DNA (2001) (0)
- DNA damage responses and chemosensitivity of breast cancer tissue slices ex vivo (2016) (0)
- PO-462 Functional ex vivo assay reveals homologous recombination deficiency in breast cancer beyond BRCA gene defects (2018) (0)
- Inflammatory Niche Signalling Drives Genotoxic Stress in Hematopoietic Stem Cells and Predicts Leukemic Evolution in Human Leukemia Predisposition Syndromes (2016) (0)
- PO-015 DNA damage response reporters in breast cancer (2018) (0)
- Inactivation of Pol θ and C-NHEJ eliminates off-target integration of exogenous DNA (2017) (0)
- Abstract P1-06-06: Direct ex vivo observation of homologous recombination defect reversal after DNA damaging chemotherapy in metastatic breast cancer patients (2019) (0)
- Distinct mobility patterns of BRCA2 molecules at DNA damage sites (2023) (0)
- 68 Conservation of the rad21 Schizosaccharomyces pombe DNA double-strand break repair gene in mammals (1996) (0)
- Abstract 805: RECAP (REpair CAPacity) identifies a subset of breast cancers unable to form RAD51 foci which are undetected by DNA-based BRCAness tests (2022) (0)
- Roles of recombination in DNA damage repair (2001) (0)
- Author response: Role of BRCA2 DNA-binding and C-terminal domain in its mobility and conformation in DNA repair (2021) (0)
- PIQMIe: a web tool for semi-quantitative proteomics applied to dissect the mechanism of cancer therapy based on interference with DNA repair. (2015) (0)
- Faculty Opinions recommendation of Targeting the DNA damage response in cancer. (2018) (0)
- Prematurely aging mice to demonstrate the role of DNA damage in aging and age-related pathology engagement in the (2005) (0)
- Biological and functional analysis of the Rad17/RFC and Rad9/Rad1/Hus1 DNA damage sensor complexes (2005) (0)
- Faculty Opinions recommendation of Multi-Invasion-Induced Rearrangements as a Pathway for Physiological and Pathological Recombination. (2018) (0)
- Abstract 16384: Molecular Genetics of Familial Abdominal Aortic Aneurysms; a Focus on SLC2A10 (2017) (0)
- OC-0395 Ex vivo validation of PET imaging for response based dose-painting of NSCLC (2021) (0)
- Abstract P6-06-02: Functional homologous recombination REpair CAPacity (RECAP) test in metastatic breast cancer biopsies (2018) (0)
- Homologous Recombinational Repair The Rad 51 Paralog Rad 51 B Promotes (2000) (0)
- Faculty Opinions recommendation of Mechanics and Single-Molecule Interrogation of DNA Recombination. (2018) (0)
- Oncogenic niche signaling in human leukemia predisposition syndromes (2016) (0)
- CHAPTER 7 HYBRID OPTICAL AND CT IMAGING REVEALS INCREASED MATRIX METALLOPROTEASE ACTIVITY AND APOPTOSIS PRECEDING CARDIAC FAILURE IN PROGEROID ERCC 1 MICE (2018) (0)
- Real-Time Visualization of DNA-protein transactions during DNA Recombination: Analysis of Mechanistic Dynamics on Single DNA Molecules (2007) (0)
- Abstract 3392: Ex vivo analysis of RAD51 foci induction in fresh tumor tissue: a promising new tool for the identification of homologous recombination-deficient tumors (2015) (0)
- PO-492 Ex vivo functional homologous recombination (HR) test detects BRCA reversal and resistance to PARPi in metastatic breast cancer patients (2018) (0)
- Tumor slice culture system to assess drug response of primary breast cancer (2016) (0)
- CHAPTER 4 FIBULIN-4 DEFICIENCY INDUCES THORACIC AND ABDOMINAL AORTIC WALL DILATION AND ALTERED PLAQUE MORPHOLOGY IN APOLIPOPROTEIN E-DEFICIENT MICE (2018) (0)
- Faculty Opinions recommendation of Two distinct conformational states define the interaction of human RAD51-ATP with single-stranded DNA. (2018) (0)
- Mechanism and biological relevance of homologous recombination in counteracting radiation and chemically-induced DNA damage (2004) (0)
- Torque-limited RecA polymerization on dsDNA (2005) (0)
- Molecular and cellular basis of genome instability in cancer (1988) (0)
- Additional file 6: Figure S6. of Tumor slice culture system to assess drug response of primary breast cancer (2016) (0)
- RADIATION-INDUCED SPERM DNA LESIONS ARE REPAIRED IN THE EGG BY MATERNAL NHEJ AND HR PATHWAYS (2007) (0)
- Herstel van dubbelstrengsbreuken en cross-links in DNA (2001) (0)
- Author response: Distinct roles of ATM and ATR in the regulation of ARP8 phosphorylation to prevent chromosome translocations (2018) (0)
- SEX-LETHAL RNA RECOGNITION DOMAINS 1 AND 2 FROM DROSOPHILA MELANOGASTER (1999) (0)
- 937 Attenuated XPC expression is not associated with impaired DNA repair in bladder cancer (2016) (0)
- BRCA2-HSF2BP Oligomeric Ring Disassembly by BRME1 Promotes Homologous Recombination (2023) (0)
- Faculty Opinions recommendation of Tumor-associated mutations in a conserved structural motif alter physical and biochemical properties of human RAD51 recombinase. (2018) (0)
- Abstract 2425: Exploiting DNA repair defects in breast cancer (2014) (0)
- Effects of radiation on cultured mucosal substitues (2007) (0)
- Functional single cell proteomic profiling of cells with abnormal DNA damage response dynamics (2021) (0)
- Abstract 15331: Reduced Fibulin-4 Expression Induces Cardiomyocyte Remodeling and Dilated Cardiomyopathy (2011) (0)
- Independent of RAD 54 Between Transgenic Antibody V Genes Are Gene Conversion-Like Sequence Transfers (2002) (0)
- Faculty Opinions recommendation of Tyrosine phosphorylation stimulates activity of human RAD51 recombinase through altered nucleoprotein filament dynamics. (2018) (0)
- Abstract 15738: PGC1alpha Regulates Decreased Mitochondrial Respiration in Aneurysmal Aortas of Fibulin-4 Mutant Mice (2017) (0)
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What Schools Are Affiliated With Roland Kanaar?
Roland Kanaar is affiliated with the following schools:
