Roland. Seifert

Roland. Seifert's AcademicInfluence.com Rankings

Roland. Seifert

Medical

#2056

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#2450

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Pharmacology

#212

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#252

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Roland. Seifert

Biology

#8160

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#11196

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Neuroscience

#1110

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#1152

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Biochemistry

#1165

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#1283

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biology Degrees

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Roland. Seifert's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Constitutive activity of G-protein-coupled receptors: cause of disease and common property of wild-type receptors (2002) (606)
Faculty Opinions recommendation of K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. (2013) (472)
Structural Instability of a Constitutively Active G Protein-coupled Receptor (1997) (280)
Guideline for acute therapy and management of anaphylaxis (2014) (184)
Involvement of pyrimidinoceptors in the regulation of cell functions by uridine and by uracil nucleotides. (1989) (173)
A liquid chromatography-coupled tandem mass spectrometry method for quantitation of cyclic di-guanosine monophosphate. (2010) (171)
THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes (2021) (161)
Molecular and cellular analysis of human histamine receptor subtypes. (2013) (144)
Molecular analysis of beta(2)-adrenoceptor coupling to G(s)-, G(i)-, and G(q)-proteins. (2000) (143)
International Union of Basic and Clinical Pharmacology. CI. Structures and Small Molecule Modulators of Mammalian Adenylyl Cyclases (2017) (140)
Analysis by high-resolution two-dimensional electrophoresis of differentiation-dependent alterations in cytosolic protein pattern of HL-60 leukemic cells. (1990) (136)
Histamine H1, H3 and H4 receptors are involved in pruritus (2011) (129)
GPCR–Gα fusion proteins: molecular analysis of receptor–G-protein coupling (1999) (128)
Different effects of Gsalpha splice variants on beta2-adrenoreceptor-mediated signaling. The Beta2-adrenoreceptor coupled to the long splice variant of Gsalpha has properties of a constitutively active receptor. (1998) (125)
Hrs-2 is an ATPase implicated in calcium-regulated secretion (1997) (124)
Cyclosporin H is a potent and selective formyl peptide receptor antagonist. Comparison with N-t-butoxycarbonyl-L-phenylalanyl-L-leucyl-L-phenylalanyl-L- leucyl-L-phenylalanine and cyclosporins A, B, C, D, and E. (1993) (121)
High Constitutive Activity of the Human Formyl Peptide Receptor* (1998) (116)
Functional differences between full and partial agonists: evidence for ligand-specific receptor conformations. (2001) (109)
Some taste substances are direct activators of G-proteins. (1994) (108)
Effects of guanine, inosine, and xanthine nucleotides on beta(2)-adrenergic receptor/G(s) interactions: evidence for multiple receptor conformations. (1999) (107)
The effect of pH on beta(2) adrenoceptor function. Evidence for protonation-dependent activation. (2000) (107)
High constitutive activity and a G-protein-independent high-affinity state of the human histamine H(4)-receptor. (2009) (105)
Cross‐linking of CD18 in human neutrophils induces an increase of intracellular free Ca2+, exocytosis of azurophilic granules, quantitative up‐regulation of CD18, shedding of L‐selectin, and actin polymerization (1994) (104)
G-protein-coupled receptors in HL-60 human leukemia cells. (1996) (103)
Differential Inhibition of Adenylyl Cyclase Isoforms and Soluble Guanylyl Cyclase by Purine and Pyrimidine Nucleotides* (2004) (102)
Inhibitors of membranous adenylyl cyclases. (2012) (99)
Lipophilic beta-adrenoceptor antagonists and local anesthetics are effective direct activators of G-proteins. (1994) (96)
Stimulus-dependent inhibition of platelet aggregation by the protein kinase C inhibitors polymyxin B, H-7 and staurosporine. (1988) (95)
Paradoxical Stimulatory Effects of the “Standard” Histamine H4-Receptor Antagonist JNJ7777120: the H4 Receptor Joins the Club of 7 Transmembrane Domain Receptors Exhibiting Functional Selectivity (2011) (95)
Reconstitution of β2-adrenoceptor−GTP-binding-protein interaction in Sf9 cells (1998) (95)
Multiple Differences in Agonist and Antagonist Pharmacology between Human and Guinea Pig Histamine H1-Receptor (2003) (89)
Guanine nucleotides stimulate NADPH oxidase in membranes of human neutrophils (1986) (83)
Activation of protein kinase C by cis- and trans-fatty acids and its potentiation by diacylglycerol. (1988) (82)
Quantitative Analysis of Formyl Peptide Receptor Coupling to Giα1, Giα2, and Giα3 * (1999) (82)
Structural Basis for the Inhibition of Mammalian Membrane Adenylyl Cyclase by 2 ′(3′)-O-(N-Methylanthraniloyl)-guanosine 5 ′-Triphosphate* (2005) (79)
Nucleotidyl cyclase activity of soluble guanylyl cyclase α1β1. (2012) (79)
Fatty-acid-induced activation of NADPH oxidase in plasma membranes of human neutrophils depends on neutrophil cytosol and is potentiated by stable guanine nucleotides. (1987) (79)
Modulation of behavior by the histaminergic system: Lessons from HDC-, H3R- and H4R-deficient mice (2014) (78)
Species-dependent activities of G-protein-coupled receptor ligands: lessons from histamine receptor orthologs. (2013) (77)
Activation and Inhibition of Adenylyl Cyclase Isoforms by Forskolin Analogs (2008) (76)
Activation of NADPH oxidase by purine and pyrimidine nucleotides involves G proteins and is potentiated by chemotactic peptides. (1989) (75)
Commercially available antibodies against human and murine histamine H4-receptor lack specificity (2012) (73)
Botulinum C2 toxin ADP-ribosylates actin and enhances O2- production and secretion but inhibits migration of activated human neutrophils. (1988) (73)
The histamine H4-receptor and the central and peripheral nervous system: A critical analysis of the literature (2016) (73)
Colors of Ag+-Exchanged Zeolite A (2000) (72)
Distinct interaction of human and guinea pig histamine H2-receptor with guanidine-type agonists. (2001) (72)
Differential inhibition of human neutrophil activation by cyclosporins A, D, and H. Cyclosporin H is a potent and effective inhibitor of formyl peptide-induced superoxide formation. (1991) (68)
Acylguanidines as bioisosteres of guanidines: NG-acylated imidazolylpropylguanidines, a new class of histamine H2 receptor agonists. (2008) (68)
Histamine increases cytosolic Ca2+ in HL-60 promyelocytes predominantly via H2 receptors with an unique agonist/antagonist profile and induces functional differentiation. (1992) (68)
Impact of the DRY Motif and the Missing “Ionic Lock” on Constitutive Activity and G-Protein Coupling of the Human Histamine H4 Receptor (2010) (67)
Incomplete activation of human eosinophils via the histamine H4-receptor: evidence for ligand-specific receptor conformations. (2012) (66)
Generation of a homology model of the human histamine H3 receptor for ligand docking and pharmacophore-based screening (2007) (66)
Purine and pyrimidine nucleotides potentiate activation of NADPH oxidase and degranulation by chemotactic peptides and induce aggregation of human neutrophils via G proteins. (1989) (66)
Sf9 cells: a versatile model system to investigate the pharmacological properties of G protein-coupled receptors. (2010) (66)
2,4-Diaminopyrimidines as histamine H4 receptor ligands--Scaffold optimization and pharmacological characterization. (2009) (65)
Cytidylyl and uridylyl cyclase activity of bacillus anthracis edema factor and Bordetella pertussis CyaA. (2010) (63)
Synthesis and structure-activity relationships of cyanoguanidine-type and structurally related histamine H4 receptor agonists. (2009) (62)
Molecular Analysis of b 2-Adrenoceptor Coupling to Gs-, Gi-, and Gq-Proteins (2000) (62)
Functional Selectivity of GPCR Ligand Stereoisomers: New Pharmacological Opportunities (2009) (62)
Receptor-specific functional efficacies of alkyl imidazoles as dual histamine H3/H4 receptor ligands. (2011) (61)
Broad Specificity of Mammalian Adenylyl Cyclase for Interaction with 2′,3′-Substituted Purine- and Pyrimidine Nucleotide Inhibitors (2006) (60)
Nucleotidyl cyclase activity of soluble guanylyl cyclase in intact cells. (2014) (59)
The human histamine H2‐receptor couples more efficiently to Sf9 insect cell Gs‐proteins than to insect cell Gq‐proteins: limitations of Sf9 cells for the analysis of receptor/Gq‐protein coupling (2002) (59)
Defective Gi Protein Coupling in Two Formyl Peptide Receptor Mutants Associated with Localized Juvenile Periodontitis* (2001) (57)
ExoY from Pseudomonas aeruginosa is a nucleotidyl cyclase with preference for cGMP and cUMP formation. (2014) (57)
cGAS-like receptors sense RNA and control 3′2′-cGAMP signalling in Drosophila (2021) (57)
N-protein kinase C isoenzymes may be involved in the regulation of various neutrophil functions. (1994) (57)
Functional selectivity of G-protein-coupled receptors: from recombinant systems to native human cells. (2013) (56)
The human formyl peptide receptor as model system for constitutively active G-protein-coupled receptors. (2003) (55)
The superoxide-forming NADPH oxidase of phagocytes. An enzyme system regulated by multiple mechanisms. (1991) (54)
Interactions of Histamine H1-Receptor Agonists and Antagonists with the Human Histamine H4-Receptor (2009) (53)
Convenient Preparation of Close-Packed Monograin Layers of Pure Zeolite A Microcrystals. (1997) (53)
The role of nucleoside-diphosphate kinase reactions in G protein activation of NADPH oxidase by guanine and adenine nucleotides. (1988) (53)
Binding Kinetics and Pathways of Ligands to GPCRs. (2017) (53)
2′(3′)-O-(N-Methylanthraniloyl)-substituted GTP Analogs: A Novel Class of Potent Competitive Adenylyl Cyclase Inhibitors* (2003) (52)
Differential activation of cAMP- and cGMP-dependent protein kinases by cyclic purine and pyrimidine nucleotides. (2011) (51)
N(G)-acylated imidazolylpropylguanidines as potent histamine H4 receptor agonists: selectivity by variation of the N(G)-substituent. (2009) (50)
The Yellow Color of Silver-Containing Zeolite A. (1998) (50)
Guideline (S2k) on acute therapy and management of anaphylaxis: 2021 update (2021) (49)
QUANTUM-SIZED SILVER SULFIDE CLUSTERS IN ZEOLITE A (1999) (48)
Activation of the β2-Adrenergic Receptor-Gαs Complex Leads to Rapid Depalmitoylation and Inhibition of Repalmitoylation of Both the Receptor and Gαs * (1999) (47)
Histamine inhibits activation of human neutrophils and HL-60 leukemic cells via H2-receptors (1989) (46)
Human cyclic nucleotide phosphodiesterases possess a much broader substrate‐specificity than previously appreciated (2011) (46)
Pharmacological Profile of Histaprodifens at Four Recombinant Histamine H1 Receptor Species Isoforms (2008) (45)
From canonical to non-canonical cyclic nucleotides as second messengers: pharmacological implications. (2015) (45)
NG‐Acylated Aminothiazolylpropylguanidines as Potent and Selective Histamine H2 Receptor Agonists (2009) (45)
Expression and functional properties of canine, rat, and murine histamine H4 receptors in Sf9 insect cells (2011) (45)
Computational and Experimental Analysis of the Transmembrane Domain 4/5 Dimerization Interface of the Serotonin 5-HT1A Receptor (2012) (45)
Does the Histamine H4 Receptor Have a Pro- or Anti-Inflammatory Role in Murine Bronchial Asthma? (2010) (45)
Activation of superoxide formation and lysozyme release in human neutrophils by the synthetic lipopeptide Pam3Cys-Ser-(Lys)4. Involvement of guanine-nucleotide-binding proteins and synergism with chemotactic peptides. (1990) (44)
cCMP and cUMP: emerging second messengers. (2015) (44)
cAMP, cGMP, cCMP and cUMP concentrations across the tree of life: High cCMP and cUMP levels in astrocytes (2014) (43)
The H1 receptor agonist 2-(3-chlorophenyl)histamine activates Gi proteins in HL-60 cells through a mechanism that is independent of known histamine receptor subtypes. (1994) (43)
Reversible activation of NADPH oxidase in membranes of HL-60 human leukemic cells. (1987) (42)
Characterization of Mouse Heart Adenylyl Cyclase (2009) (42)
Unmasking different constitutive activity of four chemoattractant receptors using Na+ as universal stabilizer of the inactive (R) state. (2001) (41)
The bivalent ligand approach leads to highly potent and selective acylguanidine-type histamine H₂ receptor agonists. (2012) (41)
Formyl peptides and ATP stimulate Ca2+ and Na+ inward currents through non-selective cation channels via G-proteins in dibutyryl cyclic AMP-differentiated HL-60 cells. Involvement of Ca2+ and Na+ in the activation of beta-glucuronidase release and superoxide production. (1992) (41)
Constitutive Activity and Ligand Selectivity of Human, Guinea Pig, Rat, and Canine Histamine H2 Receptors (2007) (40)
cCMP, cUMP, cTMP, cIMP and cXMP as possible second messengers: Development of a hypothesis based on studies with soluble guanylyl cyclase α1β1 (2013) (40)
Cyclic cytidine 3′,5′‐monophosphate (cCMP) signals via cGMP kinase I (2010) (40)
Molecular Analysis of the Interaction of Bordetella pertussis Adenylyl Cyclase with Fluorescent Nucleotides (2007) (40)
Maitotoxin activates cation channels distinct from the receptor-activated non-selective cation channels of HL-60 cells. (1994) (39)
Homology Model Adjustment and Ligand Screening with a Pseudoreceptor of the Human Histamine H4 Receptor (2009) (39)
The olfactory G protein Gαolf possesses a lower GDP‐affinity and deactivates more rapidly than Gsαshort: consequences for receptor‐coupling and adenylyl cyclase activation (2001) (38)
Molecular Analysis of the Interaction of Anthrax Adenylyl Cyclase Toxin, Edema Factor, with 2′(3′)-O-(N-(methyl)anthraniloyl)-Substituted Purine and Pyrimidine Nucleotides (2009) (37)
Nucleotidyl Cyclase Activity of Particulate Guanylyl Cyclase A: Comparison with Particulate Guanylyl Cyclases E and F, Soluble Guanylyl Cyclase and Bacterial Adenylyl Cyclases Cyaa and Edema Factor (2013) (37)
Dissociations in the Effects of β2-Adrenergic Receptor Agonists on cAMP Formation and Superoxide Production in Human Neutrophils: Support for the Concept of Functional Selectivity (2013) (37)
The class III antiarrhythmic drug amiodarone directly activates pertussis toxin-sensitive G proteins. (1995) (36)
Ligand-Specific Contribution of the N Terminus and E2-Loop to Pharmacological Properties of the Histamine H1-Receptor (2008) (36)
Cyclosporin H Is a Potent and Selective Formyl Peptide Receptor Antagonist Comparison with Nt-Butoxycarbonyl-~-phenylalanyl-L-leucyl-L-phenylalanyl-1-leucyl-L-phenylalanine and Cyclosporins (2001) (36)
No Evidence for Functional Selectivity of Proxyfan at the Human Histamine H3 Receptor Coupled to Defined Gi/Go Protein Heterotrimers (2010) (35)
Evidence for ligand-specific conformations of the histamine H(2)-receptor in human eosinophils and neutrophils. (2012) (35)
GPCR structure, function, drug discovery and crystallography: report from Academia-Industry International Conference (UK Royal Society) Chicheley Hall, 1–2 September 2014 (2015) (35)
Histamine increases cytosolic Ca2+ in dibutyryl-cAMP-differentiated HL-60 cells via H1 receptors and is an incomplete secretagogue. (1992) (35)
Soluble adenylyl cyclase accounts for high basal cCMP and cUMP concentrations in HEK293 and B103 cells. (2014) (34)
Interactions of recombinant human histamine H1, H2, H3, and H4 receptors with 34 antidepressants and antipsychotics (2012) (34)
Tritium‐Labeled N1‐[3‐(1H‐imidazol‐4‐yl)propyl]‐N2‐propionylguanidine ([3H]UR‐PI294), a High‐Affinity Histamine H3 and H4 Receptor Radioligand (2009) (33)
Structure-activity relationships of histamine H2 receptor ligands. (2004) (33)
Similar apparent constitutive activity of human histamine H(2)-receptor fused to long and short splice variants of G(salpha). (2001) (33)
Modulation of behavior by the histaminergic system: Lessons from H1R-and H2R-deficient mice (2014) (33)
Contribution of Binding Enthalpy and Entropy to Affinity of Antagonist and Agonist Binding at Human and Guinea Pig Histamine H1-Receptor (2009) (33)
Studies with protein kinase C inhibitors presently available cannot elucidate the role of protein kinase C in the activation of NADPH oxidase. (1988) (33)
Structural Requirements for Inverse Agonism and Neutral Antagonism of Indole-, Benzimidazole-, and Thienopyrrole-Derived Histamine H4 Receptor Ligands (2010) (33)
Differential activation of Gi and Gs proteins by E- and I-type prostaglandins in membranes from the human erythroleukaemia cell line, HEL. (1995) (33)
Probing Ligand-Specific Histamine H1- and H2-Receptor Conformations with NG-Acylated Imidazolylpropylguanidines (2006) (33)
Activation of GTP formation and high-affinity GTP hydrolysis by mastoparan in various cell membranes. G-protein activation via nucleoside diphosphate kinase, a possible general mechanism of mastoparan action. (1996) (32)
The histamine H4‐receptor (H4R) regulates eosinophilic inflammation in ovalbumin‐induced experimental allergic asthma in mice (2015) (32)
Synthetic lipopeptide Pam3CysSer(Lys)4 is an effective activator of human platelets. (1994) (32)
Generation of specific antibodies against the rap1A, rap1B and rap2 small GTP-binding proteins. Analysis of rap and ras proteins in membranes from mammalian cells. (1992) (32)
Receptor-mediated increases in cytosolic Ca2+ in the human erythroleukaemia cell line involve pertussis toxin-sensitive and -insensitive pathways. (1992) (32)
Analysis of Histamine Receptor Knockout Mice in Models of Inflammation (2014) (32)
Comparison of the pharmacological properties of human and rat histamine H(3)-receptors. (2010) (32)
cCMP and cUMP occur in vivo. (2015) (31)
Monovalent anions differentially modulate coupling of the beta2-adrenoceptor to G(s)alpha splice variants. (2001) (30)
Thapsigargin activates univalent- and bivalent-cation entry in human neutrophils by a SK&F I3 96365- and Gd3+-sensitive pathway and is a partial secretagogue: involvement of pertussis-toxin-sensitive G-proteins and protein phosphatases 1/2A and 2B in the signal-transduction pathway. (1996) (30)
Restricting mobility of Gsalpha relative to the beta2-adrenoceptor enhances adenylate cyclase activity by reducing Gsalpha GTPase activity. (1998) (30)
Activation of protein kinase C by cis- and trans-octadecadienoic acids in intact human platelets and its potentiation by diacylglycerol. (1987) (30)
Opposite Effects of Mepyramine on JNJ 7777120-Induced Amelioration of Experimentally Induced Asthma in Mice in Sensitization and Provocation (2012) (30)
Functional reconstitution of the human chemokine receptor CXCR4 with Gi/Go-proteins in Sf9 insect cells (2008) (30)
Molecular Basis for the Selective Interaction of Synthetic Agonists with the Human Histamine H1-Receptor Compared with the Guinea Pig H1-Receptor (2009) (28)
Differential Inhibition of Various Adenylyl Cyclase Isoforms and Soluble Guanylyl Cyclase by 2′,3′-O-(2,4,6-Trinitrophenyl)-Substituted Nucleoside 5′-Triphosphates (2009) (28)
Distinct Interactions of Human β1- and β2-Adrenoceptors with Isoproterenol, Epinephrine, Norepinephrine, and Dopamine (2008) (28)
Systematic analysis of histamine and N-methylhistamine concentrations in organs from two common laboratory mouse strains: C57Bl/6 and Balb/c (2011) (28)
GPCR-Galpha fusion proteins: molecular analysis of receptor-G-protein coupling. (1999) (28)
Histamine induces chemotaxis and phagocytosis in murine bone marrow-derived macrophages and RAW 264.7 macrophage-like cells via histamine H4-receptor (2014) (28)
Luciferase Reporter Gene Assay on Human, Murine and Rat Histamine H4 Receptor Orthologs: Correlations and Discrepancies between Distal and Proximal Readouts (2013) (27)
Different Effects of Gsα Splice Variants on β2-Adrenoreceptor-mediated Signaling (1998) (27)
Examining the efficiency of receptor/G‐protein coupling with a cleavable β2‐adrenoceptor–Gsα fusion protein (1999) (27)
How Naunyn-Schmiedeberg’s Archives of Pharmacology deals with fraudulent papers from paper mills (2021) (27)
A fluorimetric assay for real-time monitoring of adenylyl cyclase activity based on terbium norfloxacin. (2008) (27)
cNMP-AMs mimic and dissect bacterial nucleotidyl cyclase toxin effects. (2014) (26)
Characterization of histamine H2-receptors in human neutrophils with a series of guanidine analogues of impromidine (1990) (26)
Molecular determinants for the high constitutive activity of the human histamine H4 receptor: functional studies on orthologues and mutants (2015) (26)
Histamine H(4) receptor-RGS fusion proteins expressed in Sf9 insect cells: a sensitive and reliable approach for the functional characterization of histamine H(4) receptor ligands. (2009) (26)
Similarities and differences in the coupling of human β1- and β2-adrenoceptors to Gsα splice variants (2002) (26)
Receptor-independent G protein activation may account for the stimulatory effects of first-generation H1-receptor antagonists in HL-60 cells, basophils, and mast cells. (1996) (25)
Activation of NADPH Oxidase (1991) (25)
G-protein α-subunits in cytosolic and membranous fractions of human neutrophils (1989) (25)
Role of the second and third extracellular loops of the histamine H4 receptor in receptor activation (2011) (25)
Histamine receptor-dependent and/or -independent activation of guanine nucleotide-binding proteins by histamine and 2-substituted histamine derivatives in human leukemia (HL-60) and human erythroleukemia (HEL) cells. (1995) (25)
Co-expression of the beta2-adrenoceptor and dopamine D1-receptor with Gsalpha proteins in Sf9 insect cells: limitations in comparison with fusion proteins. (2003) (25)
Modulation of GPCRs by monovalent cations and anions (2015) (25)
Dimeric carbamoylguanidine-type histamine H2 receptor ligands: A new class of potent and selective agonists. (2015) (24)
Functional differences between human formyl peptide receptor isoforms 26, 98, and G6 (2003) (24)
Critical role of N-terminal N-glycosylation for proper folding of the human formyl peptide receptor. (2003) (24)
Bis-Halogen-Anthraniloyl-Substituted Nucleoside 5′-Triphosphates as Potent and Selective Inhibitors of Bordetella pertussis Adenylyl Cyclase Toxin (2011) (24)
Nucleotide-, chemotactic peptide- and phorbol ester-induced exocytosis in HL-60 leukemic cells. (1990) (24)
Regulation of the superoxide-forming NADPH oxidase of human neutrophils is not altered in essential hypertension. (1991) (24)
Quantitative analysis of formyl peptide receptor coupling to g(i)alpha(1), g(i)alpha(2), and g(i)alpha(3). (1999) (24)
The dual H3/4R antagonist thioperamide does not fully mimic the effects of the ‘standard’ H4R antagonist JNJ 7777120 in experimental murine asthma (2013) (23)
Modulation of histamine H3 receptor function by monovalent ions (2010) (23)
Alpha 2A-adrenoceptors mediate activation of non-selective cation channels via Gi-proteins in human erythroleukaemia (HEL) cells. No evidence for a functional role of imidazoline receptors in modulating calcium. (1995) (23)
Heterogeneity of Pulmonary Endothelial Cyclic Nucleotide Response to Pseudomonas aeruginosa Infection (2015) (23)
Binding of Regulatory Subunits of Cyclic AMP-Dependent Protein Kinase to Cyclic CMP Agarose (2012) (23)
Differential interactions of the catalytic subunits of adenylyl cyclase with forskolin analogs. (2009) (23)
Differential modulation by N4, 2'-O-dibutyryl cytidine 3':5'-cyclic monophosphate of neutrophil activation. (1991) (23)
Recruitment of β-Arrestin 1 and 2 to the β2-Adrenoceptor: Analysis of 65 Ligands (2015) (22)
cCMP is a substrate for MRP5 (2014) (22)
Similarly Potent Inhibition of Adenylyl Cyclase by P-Site Inhibitors in Hearts from Wild Type and AC5 Knockout Mice (2013) (22)
Nucleoside diphosphate kinase activity in soluble transducin preparations biochemical properties and possible role of transducin-beta as phosphorylated enzyme intermediate. (1999) (21)
Impact of divalent metal ions on regulation of adenylyl cyclase isoforms by forskolin analogs. (2011) (21)
Differential inhibition and potentiation of chemoattractant-induced superoxide formation in human neutrophils by the cell-permeant analogue of cyclic GMP, N2,2′-O-dibutyryl guanosine 3′:5′-cyclic monophosphate (1991) (21)
First metal-containing histamine H3 receptor ligands. (2010) (21)
Functional Adenylyl Cyclase Inhibition in Murine Cardiomyocytes by 2′(3′)-O-(N-Methylanthraniloyl)-Guanosine 5′-[γ-Thio]triphosphate (2007) (21)
N-Alkenyl and cycloalkyl carbamates as dual acting histamine H3 and H4 receptor ligands. (2011) (21)
Proinflammatory role of the histamine H4 receptor in dextrane sodium sulfate-induced acute colitis. (2015) (20)
Morphine and muscle relaxants are receptor-independent G-protein activators and cromolyn is an inhibitor of stimulated G-protein activity (1997) (20)
Nα-Imidazolylalkyl and Pyridylalkyl Derivatives of Histaprodifen: Synthesis and in Vitro Evaluation of Highly Potent Histamine H1-Receptor Agonists (2003) (20)
Influence of the N-terminus and the E2-loop onto the binding kinetics of the antagonist mepyramine and the partial agonist phenoprodifen to H(1)R. (2011) (20)
Point mutations in the second extracellular loop of the histamine H2 receptor do not affect the species-selective activity of guanidine-type agonists (2007) (20)
Selectivity of pharmacological tools: implications for use in cell physiology. A review in the theme: Cell signaling: proteins, pathways and mechanisms. (2015) (20)
Structure-activity relationships for the interactions of 2'- and 3'-(O)-(N-methyl)anthraniloyl-substituted purine and pyrimidine nucleotides with mammalian adenylyl cyclases. (2011) (20)
N1-(3-Cyclohexylbutanoyl)-N2-[3-(1H-imidazol-4-yl)propyl]guanidine (UR-AK57), a Potent Partial Agonist for the Human Histamine H1- and H2-Receptors (2006) (20)
Complex regulation of human neutrophil activation by actin filaments: dihydrocytochalasin B and botulinum C2 toxin uncover the existence of multiple cation entry pathways (1997) (19)
Mutations of Cys-17 and Ala-271 in the Human Histamine H2 Receptor Determine the Species Selectivity of Guanidine-Type Agonists and Increase Constitutive Activity (2007) (19)
Synthesis and cannabinoid receptor activity of ketoalkenes from Echinacea pallida and nonnatural analogues. (2008) (19)
Inhibition of NADPH Oxidase (1991) (19)
Histamine H(1)- and H(4)-receptor signaling cooperatively regulate MAPK activation. (2015) (18)
cCMP causes caspase-dependent apoptosis in mouse lymphoma cell lines. (2015) (18)
Differential interactions of G-proteins and adenylyl cyclase with nucleoside 5′-triphosphates, nucleoside 5′-[γ-thio]triphosphates and nucleoside 5′-[β,γ-imido]triphosphates (2005) (18)
Distinct Interactions of GTP, UTP, and CTP with GsProteins* (2002) (18)
In U-937 promonocytes, misteltoe lectin I increases basal [Ca2+]i, enhances histamine H1- and complement C5a-receptor-mediated rises in [Ca2+]i, and induces cell death (1997) (18)
The Role of Pseudomonas aeruginosa ExoY in an Acute Mouse Lung Infection Model (2018) (17)
Decreased GTP‐stimulated adenylyl cyclase activity in HPRT‐deficient human and mouse fibroblast and rat B103 neuroblastoma cell membranes (2006) (17)
Structure-bias relationships for fenoterol stereoisomers in six molecular and cellular assays at the β2-adrenoceptor (2014) (17)
Histamine and Histamine Receptors in Health and Disease (2017) (17)
Functionally nonequivalent interactions of guanosine 5'-triphosphate, inosine 5'-triphosphate, and xanthosine 5'-triphosphate with the retinal G-protein, transducin, and with Gi-proteins in HL-60 leukemia cell membranes. (1997) (17)
An extracytoplasmic protein and a moonlighting enzyme modulate synthesis of c-di-AMP in Listeria monocytogenes. (2020) (17)
Inhibitors of Bacillus anthracis edema factor. (2013) (17)
Differential activation of dibutyryl cAMP-differentiated HL-60 human leukemia cells by chemoattractants. (1994) (17)
Towards selective inhibitors of adenylyl cyclase toxin from Bordetella pertussis. (2012) (17)
Synthesis and pharmacological characterization of novel fluorescent histamine H2-receptor ligands derived from aminopotentidine. (2006) (16)
Altered membrane NTPase activity in Lesch–Nyhan disease fibroblasts: comparison with HPRT knockout mice and HPRT‐deficient cell lines (2005) (16)
Incomplete functional differentiation of HL‐60 leukemic cells by synthetic lipopetides (1992) (16)
Histamine H3 and H4 receptor affinity of branched 3-(1H-imidazol-4-yl)propyl N-alkylcarbamates. (2009) (16)
G Protein-Coupled Receptors as Drug Targets: Analysis of Activation and Constitutive Activity (2005) (16)
Analysis of the histamine H2-receptor in human monocytes. (2014) (16)
Dynamic bias and its implications for GPCR drug discovery (2014) (16)
Striking differences of action of lisuride stereoisomers at histamine H1 receptors (2006) (16)
Effects of 39 Compounds on Calmodulin-Regulated Adenylyl Cyclases AC1 and Bacillus anthracis Edema Factor (2015) (16)
Extracellular vesicles: another compartment for the second messenger, cyclic adenosine monophosphate. (2019) (16)
No Evidence for Histamine H4 Receptor in Human Monocytes (2014) (16)
Vidarabine is neither a potent nor a selective AC5 inhibitor. (2014) (15)
Concanavalin A and mistletoe lectin I differentially activate cation entry and exocytosis in human neutrophils: lectins may activate multiple subtypes of cation channels (1996) (15)
Low-affinity interactions of BODIPY-FL-GTPγS and BODIPY-FL-GppNHp with Gi- and Gs-proteins (2003) (15)
Particle Distribution in a Microporous Material (1999) (15)
Lipopeptides are effective stimulators of tyrosine phosphorylation in human myeloid cells. (1992) (15)
N4-monobutyryl-cCMP activates PKA RIα and PKA RIIα more potently and with higher efficacy than PKG Iα in vitro but not in vivo (2014) (15)
Nα-Methylated phenylhistamines exhibit affinity to the hH4R—a pharmacological and molecular modelling study (2011) (15)
Restricting the mobility of Gs alpha: impact on receptor and effector coupling. (1999) (15)
Structural Basis for the High-Affinity Inhibition of Mammalian Membranous Adenylyl Cyclase by 2′,3′-O-(N-Methylanthraniloyl)-Inosine 5′-Triphosphate (2011) (15)
Allosteric Regulation of Nucleotidyl Cyclases: An Emerging Pharmacological Target (2012) (15)
Physiological Roles of Mammalian Transmembrane Adenylyl Cyclase Isoforms. (2021) (15)
The Effect of pH on β2 Adrenoceptor Function (2000) (15)
Pharmacological characterization of adenylyl cyclase isoforms in rabbit kidney membranes (2011) (14)
A simple mechanistic terminology of psychoactive drugs: a proposal (2020) (14)
Similarities and differences in the coupling of human beta1- and beta2-adrenoceptors to Gs(alpha) splice variants. (2002) (14)
Bacillus anthracis Edema Factor Substrate Specificity: Evidence for New Modes of Action (2012) (14)
Chiral NG-acylated hetarylpropylguanidine-type histamine H2 receptor agonists do not show significant stereoselectivity. (2010) (14)
Histamine H4-receptor expression in the brain? (2014) (14)
3. Socioeconomic status, multiple risks, and development of intelligence (2001) (14)
Direct and indirect receptor‐independent G‐protein activation by cationic‐amphiphilic substances. Studies with mast cells, HL‐60 human leukemic cells and purified G‐proteins (1995) (14)
Interaction of the Diguanylate Cyclase YdeH of Escherichia coli with 2′,(3′)-Substituted Purine and Pyrimidine Nucleotides (2011) (14)
Differential coupling of the human cannabinoid receptors hCB1R and hCB2R to the G-protein Gαi2β1γ2 (2008) (13)
A conformational transition in the adenylyl cyclase catalytic site yields different binding modes for ribosyl-modified and unmodified nucleotide inhibitors. (2007) (13)
Report on the Third Symposium “cCMP and cUMP as New Second Messengers” (2014) (13)
Human neutrophils and HL-60 cells do not possess α2-adrenoceptors (1994) (13)
Sodium binding to hH3R and hH4R — a molecular modeling study (2014) (13)
Impairment of adenylyl cyclase 2 function and expression in hypoxanthine phosphoribosyltransferase-deficient rat B103 neuroblastoma cells as model for Lesch–Nyhan disease: BODIPY–forskolin as pharmacological tool (2012) (13)
Problems associated with the use of commercial and non-commercial antibodies against the histamine H4 receptor (2012) (13)
The Receptor-Bound Guanylyl Cyclase DAF-11 Is the Mediator of Hydrogen Peroxide-Induced Cgmp Increase in Caenorhabditis elegans (2013) (12)
From bedside to bench—meeting report of the 7th International Conference on cGMP “cGMP: generators, effectors and therapeutic implications” in Trier, Germany, from June 19th to 21st 2015 (2015) (12)
The therapeutic potential of histamine receptor ligands in inflammatory bowel disease. (2014) (12)
Is cIMP a second messenger with functions opposite to those of cGMP? (2014) (12)
Distinct interactions of 2'- and 3'-O-(N-methyl)anthraniloyl-isomers of ATP and GTP with the adenylyl cyclase toxin of Bacillus anthracis, edema factor. (2009) (12)
Establishment of recombinant cannabinoid receptor assays and characterization of several natural and synthetic ligands (2010) (12)
Serotonergic System (2019) (11)
Differential regulation of chemoattractant-induced superoxide formation in human neutrophils by cell-permeant analogues of cyclic AMP and cyclic GMP. (1991) (11)
Rethinking Pharmacological Nomenclature. (2018) (11)
Distinct interactions of Gsα-long, Gsα-short, and Gαolf with GTP, ITP, and XTP (2002) (11)
High constitutive Akt2 activity in U937 promonocytes: effective reduction of Akt2 phosphorylation by the histamine H2-receptor and the β2-adrenergic receptor (2015) (11)
Identification of small molecules that interfere with c-di-GMP signaling and induce dispersal of Pseudomonas aeruginosa biofilms (2021) (11)
Activation of soluble guanylyl cyclase signalling with cinaciguat improves impaired kidney function in diabetic mice (2021) (11)
Characterization of histamine Ha-receptors in human neutrophils with a series of guanidine analogues of impromidine Are cell type-specific Ha-receptors involved in the regulation of NADPH oxidase? (11)
Inhibition of the adenylyl cyclase toxin, edema factor, from Bacillus anthracis by a series of 18 mono- and bis-(M)ANT-substituted nucleoside 5′-triphosphates (2011) (11)
Lipopeptides activate Gi-proteins in dibutyryl cyclic AMP-differentiated HL-60 cells. (1993) (10)
Impact of fusion to Gαi2 and co‐expression with RGS proteins on pharmacological properties of human cannabinoid receptors CB1R and CB2R (2011) (10)
Synthetic lipopeptides activate nucleoside diphosphate kinase in HL-60 membranes. (1995) (10)
Different effects of Gsalpha splice variants on beta2-adrenoreceptor-mediated signaling. The beta2-adrenoreceptor coupled to the long splice variant of Gsalpha has properties of a constitutively active receptor. (1998) (10)
Xanthine nucleotide-specific G-protein α-subunits: a novel approach for the analysis of G-protein-mediated signal transduction (2004) (10)
The prostacyclin analogues, cicaprost and iloprost, increase cytosolic Ca2+ concentration in the human erythroleukemia cell line, HEL, via pertussis toxin-insensitive G-proteins. (1992) (10)
Functional reconstitution of human neuropeptide Y (NPY) Y2 and Y4 receptors in Sf9 insect cells (2011) (10)
Altered histamine neurotransmission in HPRT-deficient mice (2015) (10)
Coexpression systems as models for the analysis of constitutive GPCR activity. (2010) (10)
Structure-Activity Relationships of Histamine H_2 Receptor Ligands, (2004) (10)
Chemoattractant Receptor-G-Protein Coupling (2001) (10)
[Covid-19 vaccination and risk of anaphylaxis - Recommendations for practical management]. (2021) (10)
cCMP and cUMP Across the Tree of Life: From cCMP and cUMP Generators to cCMP- and cUMP-Regulated Cell Functions. (2017) (10)
Properties of Arg389-β 1 -Adrenoceptor-G sα Fusion Proteins: Comparison with Gly389-β 1 -Adrenoceptor-G sα Fusion Proteins (2003) (10)
Histamine H1-receptors in HL-60 monocytes are coupled to Gi-proteins and pertussis toxin-insensitive G-proteins and mediate activation of Ca2+ influx without concomitant Ca2+ mobilization from intracellular stores (1994) (10)
Identification and quantitation of 2´,3´-cGMP in murine tissues (2013) (10)
Efficient adenylyl cyclase activation by a β2-adrenoceptor-Giα2 fusion protein (2002) (10)
Reconstitution of beta2-adrenoceptor-GTP-binding-protein interaction in Sf9 cells--high coupling efficiency in a beta2-adrenoceptor-G(s alpha) fusion protein. (1998) (10)
Mathematical analysis of the sodium sensitivity of the human histamine H3 receptor (2014) (10)
Examination of ligand-induced conformational changes in the beta2 adrenergic receptor. (1998) (9)
Interactions of Bordetella pertussis adenylyl cyclase toxin CyaA with calmodulin mutants and calmodulin antagonists: comparison with membranous adenylyl cyclase I. (2012) (9)
Analysis of Substrate Specificity and Kinetics of Cyclic Nucleotide Phosphodiesterases with N’-Methylanthraniloyl-Substituted Purine and Pyrimidine 3′,5′-Cyclic Nucleotides by Fluorescence Spectrometry (2013) (9)
Characterization of ligand-induced conformational states in the beta 2 adrenergic receptor. (1999) (9)
Differential expression of cytosolic activation factors for NADPH oxidase in HL-60 leukemic cells. (1989) (9)
Membranous adenylyl cyclase 1 activation is regulated by oxidation of N- and C-terminal methionine residues in calmodulin. (2015) (9)
Species-dependent activities of GPCR ligands: Lessons from histamine receptor orthologs (2013) (9)
Commercially available antibodies against human and murine histamine H4-receptor lack specificity (2011) (9)
GDP Affinity and Order State of the Catalytic Site Are Critical for Function of Xanthine Nucleotide-selective GαsProteins* (2003) (9)
Lack of Histamine H4-Receptor Expression Aggravates TNBS-Induced Acute Colitis Symptoms in Mice (2017) (9)
Temporal and organ-specific detection of cNMPs including cUMP in the zebrafish. (2015) (9)
Activation by beta-carbolines of G-proteins in HL-60 membranes and the bovine retinal G-protein transducin in a receptor-independent manner. (1997) (9)
How do basic secretagogues activate mast cells? (2015) (9)
Stimulation of histamine H2- (and H1)-receptors activates Ca2+ influx in all-atrans-retinoic acid-differentiated HL-60 cells independently of phospholipase C or adenylyl cyclase (2004) (9)
Differential inhibition and potentiation by cell-permeant analogues of cyclic AMP and cyclic GMP and NO-containing compounds of exocytosis in human neutrophils (1991) (8)
Structure/Activity Relationships of (M)ANT- and TNP-Nucleotides for Inhibition of Rat Soluble Guanylyl Cyclase α1β1 (2014) (8)
Fusion proteins as model systems for the analysis of constitutive GPCR activity. (2010) (8)
Search for novel, high affinity histamine H3 receptor ligands with fluorescent properties (2010) (8)
Incomplete functional differentiation of HL-60 leukemic cells by synthetic lipopeptides. Partial inhibition by pertussis toxin of enhanced superoxide formation. (1992) (8)
The olfactory G protein G(alphaolf) possesses a lower GDP-affinity and deactivates more rapidly than G(salphashort): consequences for receptor-coupling and adenylyl cyclase activation. (2001) (8)
The Pseudomonas aeruginosa ExoY phenotype of high-copy-number recombinants is not detectable in natural isolates (2018) (8)
Regulation of apoptosis by cyclic nucleotides in human erythroleukemia (HEL) cells and human myelogenous leukemia (K-562) cells. (2016) (8)
Distinct Signalling Pathways of Murine Histamine H1- and H4-Receptors Expressed at Comparable Levels in HEK293 Cells (2014) (8)
Why Naunyn–Schmiedeberg’s Archives of Pharmacology abandons traditional names of drug classes (2021) (7)
Complex changes in ecto-nucleoside 5′-triphosphate diphosphohydrolase expression in hypoxanthine phosphoribosyl transferase deficiency (2007) (7)
Lead identification and optimization of diaminopyrimidines as histamine H4 receptor ligands (2010) (7)
2-Substituted histamines with G-protein-stimulatory activity (1995) (7)
N(alpha)-imidazolylalkyl and pyridylalkyl derivatives of histaprodifen: synthesis and in vitro evaluation of highly potent histamine H(1)-receptor agonists. (2003) (7)
Evidence that inhibition of phorbol ester-induced superoxide anion formation by cyclosporin A in phagocytes is not mediated by direct inhibition of protein kinase C. (1994) (7)
2-Alkyl-substituted histamines and hydroxyethylimidazoles with G-protein-stimulatory activity (1996) (7)
Adenylyl cyclase regulation in heart failure due to myocardial infarction in rats (2014) (7)
Cyclic CMP and cyclic UMP: new (old) second messengers (2011) (7)
Neurotransmitter and their metabolite concentrations in different areas of the HPRT knockout mouse brain (2016) (7)
Lack of effect of opioid peptides, morphine and naloxone on superoxide formation in human neutrophils and HL-60 leukemic cells (1989) (7)
Faculty Opinions recommendation of Spectinamides: a new class of semisynthetic antituberculosis agents that overcome native drug efflux. (2014) (7)
Preparations of Rp‐cyclic adenosine 3',5'‐phosphorothioate (Rp‐cAMPS) can contain biologically active amounts of adenosine (1993) (7)
N 1-( 3-Cyclohexylbutanoyl )-N 2-[ 3-( 1 H-imidazol-4-yl ) propyl ] guanidine ( UR-AK 57 ) , a Potent Partial Agonist for the Human Histamine H 1-and H 2-Receptors (2006) (7)
MANT-substituted guanine nucleotides: a novel class of potent adenylyl cyclase inhibitors. (2003) (7)
Effect of MANT-nucleotides on L-type calcium currents in murine cardiomyocytes (2011) (6)
Human neutrophils and HL-60 cells do not possess alpha 2-adrenoceptors. (1994) (6)
Hydrolysis of methane-, chloromethane-, and dichloromethanesulfonyl chlorides (1973) (6)
Synthesis of 5-(subst.imino)-1,3,4-dithiazolidine 3,3-dioxides by reaction of isothiocyanates with chloromethanesulfonamide (1977) (6)
Interaction of fenoterol stereoisomers with β2-adrenoceptor-Gsα fusion proteins: antagonist and agonist competition binding (2015) (6)
cUMP hydrolysis by PDE3A (2016) (6)
[Rationalized lithium adjustment by load-test (author's transl)]. (1975) (6)
Histamine via the histamine H₂-receptor reduces α-CD3-induced interferon-γ synthesis in murine CD4+ T cells in an indirect manner. (2012) (6)
Genetic Deficiency of the Histamine H4-Receptor Reduces Experimental Colorectal Carcinogenesis in Mice (2020) (6)
Putative Nucleotide-Based Second Messengers in the Archaeal Model Organisms Haloferax volcanii and Sulfolobus acidocaldarius (2021) (6)
Distinct Signaling Roles of cIMP, cCMP, and cUMP. (2016) (6)
In vivo Evidence for Partial Activation of Eosinophils via the Histamine H4-Receptor: Adoptive Transfer Experiments Using Eosinophils From H4R−/− and H4R+/+ Mice (2018) (6)
Partial inhibition of human neutrophil activation by FK-506 at supratherapeutic concentrations (1993) (6)
α2A-adrenoceptors mediate activation of non-selective cation channels via Gi-proteins in human erythroleukaemia (HEL) cells (1995) (5)
Impaired P2X and P2Y receptor-mediated signaling in HPRT-deficient B103 neuroblastoma cells (2011) (5)
Non-targeted metabolomics by high resolution mass spectrometry in HPRT knockout mice. (2016) (5)
cCMP and cUMP in Apoptosis: Concepts and Methods. (2017) (5)
How criminal science publishing gangs damage the genesis of knowledge and technology—a call to action to restore trust (2021) (5)
Synthesis of 4,5-disubstituted 1,3,4-dithiazolidine 3,3-dioxides (1977) (5)
IN MEMBRANES OF HL-60 HUMAN LEUKEMIC CELLS (1987) (5)
Pseudomonas aeruginosa ExoY, a cyclic GMP- and cyclic UMP-generating nucleotidyl cyclase (2013) (5)
A case to stop the use of the term 'antibiotics'. (2021) (5)
Flow cytometric analysis with a fluorescently labeled formyl peptide receptor ligand as a new method to study the pharmacological profile of the histamine H2 receptor (2015) (5)
Pharmacological Characterization of Human Histamine Receptors and Histamine Receptor Mutants in the Sf9 Cell Expression System (2017) (4)
Bibliometric development of Naunyn–Schmiedeberg’s Archives of Pharmacology (2022) (4)
Recruitment of b-Arrestin 1 and 2 to the b 2-Adrenoceptor : Analysis of 65 Ligands s (2015) (4)
Apoptotic and anti-proliferative effect of guanosine and guanosine derivatives in HuT-78 T lymphoma cells (2020) (4)
Does Vidarabine Mediate Cardioprotection via Inhibition of AC5? (2016) (4)
Synthesis of a hydrolytically stable, fluorescent-labeled ATP analog as a tool for probing adenylyl cyclases. (2010) (4)
cUMP hydrolysis by PDE3B (2017) (4)
The C1 homodimer of adenylyl cyclase binds nucleotides with high affinity but possesses exceedingly low catalytic activity (2009) (4)
G-protein alpha-subunits in cytosolic and membranous fractions of human neutrophils. (1989) (4)
Interaction of the retinal G-protein transducin with uracil nucleotides. (1999) (4)
Gender-specific analysis of the authors and the editorial board of Naunyn–Schmiedeberg’s Archives of Pharmacology from 2000 to 2020 (2021) (4)
Octopamine drives honeybee thermogenesis (2021) (4)
Examining the efficiency of receptor/G-protein coupling with a cleavable beta2-adrenoceptor-gsalpha fusion protein. (1999) (4)
Histamine induces chemotaxis and phagocytosis in murine bone marrow-derived macrophages and RAW 264.7 macrophage-like cells via histamine H4-receptor (2013) (4)
Mouse Colonic Epithelial Cells Functionally Express the Histamine H4 Receptor (2020) (4)
Therapeutic Efficacy of a H4 Receptor Antagonist in Humans: A Milestone in Histamine Research (2014) (4)
Inactivation of Non-canonical Cyclic Nucleotides: Hydrolysis and Transport. (2017) (4)
Synthesis and Pharmacological Properties of New Tetracyclic Forskolin Analogues (2009) (4)
Quantitation of cyclic nucleotides in mammalian cells and in human urine by high-performance liquid chromatography/mass spectrometry (2011) (3)
Effects of Impromidine- and Arpromidine-Derived Guanidines on Recombinant Human and Guinea Pig Histamine H1 and H2 Receptors. (2007) (3)
Revised editorial guidelines for manuscripts on the pharmacology of plant extracts (2017) (3)
Neutrophilic superoxide production can assess pharmacological and pharmacogenetic β‐adrenoreceptor effects (2016) (3)
Perspective article: A proposal for rational drug class terminology (2022) (3)
A door opener for future research: agonist-induced β3-adrenoceptor desensitization in HEK cells but not CHO cells (2013) (3)
Gender-specific analysis of the authors and the editorial board of Naunyn–Schmiedeberg’s Archives of Pharmacology from 2000 to 2020 (2021) (3)
Different Roles of N-Terminal and C-Terminal Domains in Calmodulin for Activation of Bacillus anthracis Edema Factor (2015) (3)
Adenylyl and Guanylyl Cyclase Assays (2005) (3)
Cationic amphiphiles with G-protein-stimulatory activity: studies on the role of the basic domain in the activation process. (1996) (3)
Low-affinity interactions of BODIPY-FL-GTPgammaS and BODIPY-FL-GppNHp with G(i)- and G(s)-proteins. (2003) (3)
History of pharmacology:2 - The Institute of Pharmacology of the University of Strasbourg: genealogy and biographies (2022) (2)
Zebrafish as model organism for cNMP research (2015) (2)
[Receptor independent activation of G proteins]. (1996) (2)
Non-canonical Cyclic Nucleotides (2017) (2)
Histamine receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database (2019) (2)
Cationic-amphiphilic arpromidine-derived guanidines and a histamine trifluoromethyl-toluidide derivative may activate pertussis toxin-sensitive G-proteins by a receptor-independent mechanism (1995) (2)
Assessing the Use of the sGC Stimulator BAY-747, as a Potential Treatment for Duchenne Muscular Dystrophy (2021) (2)
Properties of Arg389-beta1-adrenoceptor-Gsalpha fusion proteins: comparison with Gly389-beta1-adrenoceptor-Gsalpha fusion proteins. (2003) (2)
Naunyn-Schmiedeberg’s Archives of Pharmacology under new editorship: change and continuity (2016) (2)
Restricting the Mobility of Gs R : Impact on Receptor and Effector Coupling (1999) (2)
Quantum‐Sized Silver Sulfide Clusters in Zeolite A. (1999) (2)
Search for histamine H4 receptor ligands in the group of 4-methylpiperazino amide derivatives (2010) (2)
Messages for patients and relatives from the 2021 update of the guideline on acute therapy and management of anaphylaxis (2021) (2)
Emerging Role of Phosphodiesterase 2A in Hypertension. (2015) (2)
Molsidomine inhibits the chemoattractant-induced respiratory burst in human neutrophils via a no-independent mechanism. (1992) (2)
Probiotics in Naunyn–Schmiedeberg’s Archives of Pharmacology (2021) (2)
History of pharmacology: 1—the Department of Pharmacology of the University of Tartu (Dorpat): genealogy and biographies (2022) (2)
Towards rational drug treatment of Lesch-Nyhan disease. (2016) (2)
Inhibition of the adenylyl cyclase toxin, edema factor, from Bacillus anthracis by a series of 18 mono- and bis-(M)ANT-substituted nucleoside 5′-triphosphates (2011) (2)
Drugs for treatment of fungal infections. (1992) (2)
Impairment of adenylyl cyclase 2 function and expression in hypoxanthine phosphoribosyltransferase-deficient rat B103 neuroblastoma cells as model for Lesch–Nyhan disease: BODIPY–forskolin as pharmacological tool (2012) (1)
Differentiation between first and second messenger effects of cGMP (2015) (1)
Reflections on the 150th anniversary of Naunyn–Schmiedeberg’s Archives of Pharmacology: past, challenges, and future (2022) (1)
Differential interactions of G-proteins and adenylyl cyclase with nucleoside 5'-triphosphates, nucleoside 5'-[gamma-thio]triphosphates and nucleoside 5'-[beta,gamma-imido]triphosphates. (2005) (1)
Correction to Nucleotidyl Cyclase Activity of Soluble Guanylyl Cyclase α1β1 (2012) (1)
Faculty Opinions recommendation of Measuring the effectiveness of scientific gatekeeping. (2015) (1)
Restricting mobility of G s a relative to the b 2 -adrenoceptor enhances adenylate cyclase activity by reducing G s a GTPase activity (1998) (1)
Drugs for Treatment of Gastrointestinal Diseases (2019) (1)
Cannabinoid receptor Gα fusion proteins as a highly sensitive model system for characterization of receptor ligands (2009) (1)
Effects of Impromidine‐ and Arpromidine‐Derived Guanidines on Recombinant Human and Guinea Pig Histamine H1 and H2 Receptors (2007) (1)
Computational and Experimental Analysis of the Transmembrane Domain 4/5 Dimerization Interface of the Serotonin 5-HT1A Receptor □S (2012) (1)
The effector protein ExoY secreted by Pseudomonas aeruginosa is a nucleotidyl cyclase with preference for GTP (2011) (1)
[Successful therapy of phenprocoumon poisoning with plasmapheresis]. (1998) (1)
Hydrolysis of the non-canonical cyclic nucleotide cUMP by PDE9A: kinetics and binding mode (2018) (1)
Sometaste substances aredirect activators ofG-proteins (1994) (1)
Structure / Activity Relationships of ( M ) ANT-and TNP-Nucleotides for Inhibition of Rat Soluble Guanylyl Cyclase a 1 b 1 (2014) (1)
Fishing for elusive cCMP-degrading phosphodiesterases (2013) (1)
Drugs for Treatment of Schizophrenia (2019) (1)
Drugs for Treatment of Diabetes Mellitus (2019) (1)
Reconstitution and regulation of NADPH Oxidase activity in cell-free systems (1991) (1)
Sensitive assay for the detection of cyclic nucleotides by mass spectrometry (2009) (1)
Differentiation between first and second messenger effects of cGMP (2015) (1)
Constitutive Activity of β‐Adrenoceptors: Analysis in Membrane Systems (2006) (1)
Activation profile of cGMP-dependent protein kinase Iα (2013) (1)
Quantitation of cyclic dinucleotides by reversed-phase LC-MS/MS (2009) (1)
The Solid-State Substitution Reaction between Halogenoacetates and Metal Halides (1996) (1)
Frontiers in Medicinal Chemistry in Regensburg (2008) (1)
Activation of cGMP-dependent protein kinase Iα and cAMP-dependent protein kinase A isoforms by cyclic nucleotides (2011) (1)
Inside Cover: Tritium-Labeled N1-[3-(1H-imidazol-4-yl)propyl]-N2-propionylguanidine ([3H]UR-PI294), a High-Affinity Histamine H3 and H4 Receptor Radioligand / NG-Acylated Aminothiazolylpropylguanidines as Potent and Selective Histamine H2 Receptor Agonists (ChemMedChem 2/2009) (2009) (1)
Efficient adenylyl cyclase activation by a beta2-adrenoceptor-G(i)alpha2 fusion protein. (2002) (1)
Adenylyl cyclases (ACs) (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database (2019) (1)
Fishing for elusive cCMP-degrading phosphodiesterases (2013) (1)
Mathematical analysis of the sodium sensitivity of the human histamine H3 receptor (2014) (1)
Identification and quantitation of 2´,3´-cGMP in murine tissues (2013) (1)
Guideline (S2k) on acute therapy and management of anaphylaxis - 2021 Update (2021) (1)
Buchrezension zu: A Funny Thing Happened on the Way to Stockholm (2021) (1)
Recent progress in the field of cIMP research (2016) (1)
Problems associated with the use of commercial and non-commercial antibodies against the histamine H4 receptor (2012) (0)
Cytidylyl cyclase activity of bacterial exotoxins (2009) (0)
Roland Seifert Emerging Role of Phosphodiesterase 2 A in Hypertension (0)
Drugs for Treatment of Thyroid Gland Diseases (2019) (0)
Drug Allergy (2019) (0)
Nucleotidyl cyclase activity of recombinant soluble guanylyl cyclase (2009) (0)
Histamine H4-receptor expression in the brain? (2014) (0)
The effector protein ExoY secreted by Pseudomonas aeruginosa augments the inflammatory reaction in the respiratory tract of mice (2014) (0)
Cholinergic and Adrenergic System (2019) (0)
Histamine increases Ca^2+ in dibutyryl cyclic AMP-differentiated HL-60 cells via H_1-receptors and is an incomplete secretagogue (1992) (0)
Enzymes of the AKR1B and AKR1C subfamilies and uterine diseases (2012) (0)
NOVEL INORGANIC RING SYSTEMS. 33. CYCLO- AND SPIROSTANNASILAZANES (1978) (0)
From bedside to bench—meeting report of the 7th International Conference on cGMP “cGMP: generators, effectors and therapeutic implications” in Trier, Germany, from June 19th to 21st 2015 (2015) (0)
The role of the type 3 secretion system effector protein ExoY during pathogenesis of pseudomonas aeruginosa lung infections (2014) (0)
Stimulation and reduction of tumor cell growthin vitro by activation and inhibition of non-selective cation channels (2007) (0)
The Yellow Color of Silver‐Containing Zeolite A. (1998) (0)
Drugs for Treatment of Respiratory Tract Diseases (2019) (0)
Interaction of fenoterol stereoisomers with β2-adrenoceptor-Gsα fusion proteins: antagonist and agonist competition binding (2015) (0)
STRUCTURAL BASIS FOR THE INHIBITION OF MAMMALIAN ADENYLYL CYCLASE BY MANT-GTP (2004) (0)
Textbook Basic Knowledge Pharmacology (2018) (0)
cUMP hydrolysis by PDE3B (2018) (0)
[Therapy of schizophrenia]. (2008) (0)
Pathology of NADPH Oxidase (1991) (0)
Distinct Interactions of Human (cid:1) 1 - and (cid:1) 2 -Adrenoceptors with Isoproterenol, Epinephrine, Norepinephrine, and Dopamine (2008) (0)
Histamine receptors in GtoPdb v.2021.3 (2021) (0)
Structure-bias relationships for fenoterol stereoisomers in six molecular and cellular assays at the β2-adrenoceptor (2014) (0)
Buchrezension zu: The Illusion of Evidence-Based Medicine (2020) (0)
Correction to: Why Naunyn–Schmiedeberg’s Archives of Pharmacology abandons traditional names of drug classes (2021) (0)
Drugs for Treatment of Chronic Heart Failure and Coronary Heart Disease (2019) (0)
Activation profile of cGMP-dependent protein kinase Iα (2013) (0)
A GGDEF domain serves as a spatial on-switch for a phosphodiesterase by direct interaction with a polar landmark protein (2021) (0)
Buchrezension zu: The Doctor Who Fooled the World (2021) (0)
Drug-Induced Arrhythmias and Drugs for the Treatment of Arrhythmias (2019) (0)
Faculty Opinions recommendation of Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells. (2014) (0)
SC12 G-protein activation via nucleoside diphosphate kinase (1994) (0)
Critical analysis of the prescription and evaluation of protein kinase inhibitors for oncology in Germany. (2023) (0)
Drugs for the Treatment of Bacterial Infections (2019) (0)
ORGANIC HERBICIDES. VIII. SYNTHESIS OF 4,5-DISUBSTITUTED 1,3,4-DITHIAZOLIDINE E 3,3-DIOXIDES (1977) (0)
N4-monobutyryl-cCMP activates PKA RIα and PKA RIIα more potently and with higher efficacy than PKG Iα in vitro but not in vivo (2014) (0)
Adrenaline as the medication of choice. (2015) (0)
Faculty Opinions recommendation of Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions. (2015) (0)
Arachidonic Acid-Induced Activation of NADPH Oxidase in Membranes of Human Neutrophils and HL-60 Leukemic Cells is Regulated by Guanine Nucleotide-Binding Proteins and is Independent of Ca2+ and Protein Kinase C (1988) (0)
The “100 List” of Drugs (2019) (0)
c-di-AMP signaling is required for bile salts resistance and long-term colonization by Clostridioides difficile (2021) (0)
Drugs for the Treatment of Alzheimer’s Disease (2019) (0)
Drugs for Treatment of Osteoporosis (2019) (0)
Faculty Opinions recommendation of Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide. (2013) (0)
Modulation of allergic airway inflammation by the histamine H 4 receptor: analysis by flow cytometry (2012) (0)
Drugs for Treatment of Dyslipidemias (2019) (0)
NOVEL INORGANIC RING SYSTEMS. 31. SPIRO(3,4)- AND (4,4)-GERMASILAZANES WITH GERMANIUM IN THE SPIRAL CENTER (1978) (0)
Drugs for Treatment of Hypertension (2019) (0)
Regulation of G protein subunit composition in cardiomyocytes: pharmacological implications (2013) (0)
Integrative Case Studies (2019) (0)
Is cIMP a second messenger with functions opposite to those of cGMP? (2014) (0)
2‐Alkyl‐Substituted Histamines and Hydroxyethylimidazoles with G‐ Protein‐Stimulatory Activity. (1996) (0)
Pain Pharmacology (2019) (0)
Herz/Kreislauf-Erkrankungen (2021) (0)
Antigout Drugs (2020) (0)
Drugs for the Treatment of Glaucoma and Age-Related Macular Degeneration (2019) (0)
Faculty Opinions recommendation of The histamine H₄ receptor antagonist, JNJ 39758979, is effective in reducing histamine-induced pruritus in a randomized clinical study in healthy subjects. (2014) (0)
Correction to: Bibliometric development of Naunyn–Schmiedeberg’s Archives of Pharmacology (2022) (0)
Correction: The Receptor-Bound Guanylyl Cyclase DAF-11 Is the Mediator of Hydrogen Peroxide-Induced cGMP Increase in Caenorhabditis elegans (2013) (0)
Complex Of Gs- With The Catalytic Domains Of Mammalian Adenylyl Cyclase: Complex With 2'(3')-O-(N-methylanthraniloyl)-guanosine 5'-triphosphate and Mn (2004) (0)
Faculty Opinions recommendation of Mutations in GNAL cause primary torsion dystonia. (2013) (0)
Treatment of Drug Intoxications (2019) (0)
Introduction and Pharmacodynamics (2019) (0)
Drugs for Treatment of Gout (2019) (0)
Adenylyl cyclase regulation in heart failure due to myocardial infarction in rats (2013) (0)
Regulation of G protein subunit composition in cardiomyocytes: pharmacological implications (2013) (0)
Act Immediately Upon Onset of Symptoms. (2018) (0)
How do basic secretagogues activate mast cells? (2015) (0)
CONTRIBUTIONS TO THE CHEMISTRY OF SILICON-NITROGEN COMPOUNDS, 145. SPIRANES WITH GERMANIUM IN THE SPIRAL CENTER AND WITH SILICON, CARBON AND NITROGEN AS THE FRAMEWORK ATOMS (1978) (0)
Revised editorial guidelines for manuscripts on the pharmacology of plant extracts (2017) (0)
Microsoft Word-91201841-file00 (2012) (0)
NOVEL INORGANIC RING SYSTEMS. 30. CYCLOGERMADISILADIAZANES (1978) (0)
Molecular analysis of agonist stereoisomers at β2-adrenoceptors (2012) (0)
P88 receptor-independent G-protein activation by 2-substiituted histamines (1994) (0)
Distinct interactions of G(salpha-long), G(salpha-short), and G(alphaolf) with GTP, ITP, and XTP. (2002) (0)
Magen/Darm-Erkrankungen (2021) (0)
ORGANIC HERBICIDES. VII. SYNTHESIS OF 5-SUBSTITUTED IMINO-1,3,4-DITHIAZOLIDINE 3,3-DIOXIDES BY REACTION OF ISOTHIOCYANATES WITH CHLOROMETHANESULFONAMIDE (1977) (0)
Interactions of recombinant human histamine H1, H2, H3, and H4 receptors with 34 antidepressants and antipsychotics (2011) (0)
Drugs for Treatment of Thromboembolic Diseases (2019) (0)
cCMP is a substrate for MRP5 (2014) (0)
cIMP: Synthesis, effector activation, inactivation and occurrence in biological systems (2015) (0)
Report on the Third Symposium “cCMP and cUMP as New Second Messengers” (2014) (0)
Flow cytometric analysis with a fluorescently labeled formyl peptide receptor ligand as a new method to study the pharmacological profile of the histamine H2 receptor (2015) (0)
Buchrezension zu: Science Fictions (2020) (0)
cUMP hydrolysis by PDE3A (2016) (0)
Faculty Opinions recommendation of Vibrio vulnificus biotype 3 multifunctional autoprocessing RTX toxin is an adenylate cyclase toxin essential for virulence in mice. (2014) (0)
Drugs for the Treatment of Malignant Tumor Diseases (2019) (0)
Drugs for Treatment of Depression and Bipolar Disorder (2019) (0)
Neuron Inhibitors with Pleiotropic Effects and Allosteric GABAAR Modulators (2019) (0)
Apoptotic and anti-proliferative effect of guanosine and guanosine derivatives in HuT-78 T lymphoma cells (2020) (0)
High constitutive Akt2 activity in U937 promonocytes: effective reduction of Akt2 phosphorylation by the histamine H2-receptor and the β2-adrenergic receptor (2015) (0)
The dual H3/4R antagonist thioperamide does not fully mimic the effects of the ‘standard’ H4R antagonist JNJ 7777120 in experimental murine asthma (2013) (0)
Inside Cover: Homology Model Adjustment and Ligand Screening with a Pseudoreceptor of the Human Histamine H4 Receptor (ChemMedChem 5/2009) (2009) (0)
Age- and sex-ralated alterations of the activity of NADPH Oxidase (1991) (0)
FC19 activation of G-proteins in physiological and reconstituted membranous systems (1994) (0)
[Clinical experience with blood vessel ligation in uncontrollable nosebleed]. (1983) (0)
Sex Hormones: Hormonal Contraception and Hormone Replacement Therapy (2019) (0)
[Lithium therapy]. (1982) (0)
Pharmacology of the Kidney (2019) (0)
Evidence for two catalytic centers and Mn2+ as physiological cofactor of soluble guanylyl cyclase (2011) (0)
Problems associated with the use of the term “antibiotics” (2021) (0)
Faculty Opinions recommendation of Crystal structures of the catalytic domain of human soluble guanylate cyclase. (2013) (0)
Naunyn-Schmiedeberg’s Archives of Pharmacology under new editorship: change and continuity (2016) (0)
Systematic analysis of the pharmacological content of the Tatort (scene of crime) TV series from 2019 to 2021. (2023) (0)
NADPH Oxidase: A superoxide-forming enzyme system (1991) (0)
Hydrolysis of the non-canonical cyclic nucleotide cUMP by PDE9A: kinetics and binding mode (2018) (0)
Inhalation and Injection Anesthetics (2019) (0)
Analysis of natural and synthetic cannabinoid receptor ligands via [32P]GTPase assay (2007) (0)
Faculty Opinions recommendation of Macrophage biology in development, homeostasis and disease. (2013) (0)
Lipopeptides activate G ,-proteins in dibutyryl cyclic AMP-differentiated HL-60 cells (2005) (0)
HYDROLYSIS OF METHANE-, CHLOROMETHANE- AND DICHLOROMETHANESULFONYL CHLORIDES (1973) (0)
Drugs for the Treatment of Viral Infections (2019) (0)
Complex of GS-alpha with the catalytic domains of mammalian adenylyl cyclase: complex with MANT-ITP and Mn (2010) (0)
ExoY from Pseudomonas aeruginosa, a preferential guanylyl and uridylyl cyclase (610.2) (2014) (0)
A simple mechanistic terminology of psychoactive drugs: a proposal (2020) (0)
Modulation of GPCRs by monovalent cations and anions (2014) (0)
Correspondence (letter to the editor): Numerous errors. (2013) (0)
A door opener for future research: agonist-induced β3-adrenoceptor desensitization in HEK cells but not CHO cells (2013) (0)
GPCR structure, function, drug discovery and crystallography: report from Academia-Industry International Conference (UK Royal Society) Chicheley Hall, 1–2 September 2014 (2015) (0)

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University of Regensburg
Free University of Berlin
Hannover Medical School
Stanford University
University of Bern

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