Rolf Prof. Dr. Gebhardt

Rolf Prof. Dr. Gebhardt's AcademicInfluence.com Rankings

Biology

#9325

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#12515

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Cell Biology

#395

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#405

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Molecular Biology

#1263

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#1290

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Biochemistry

#1413

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#1537

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Biology

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Rolf Prof. Dr. Gebhardt's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME (2013) (1068)
Metabolic zonation of the liver: regulation and implications for liver function. (1992) (538)
Glycogen in astrocytes: possible function as lactate supply for neighboring cells (1993) (520)
Heterogeneous distribution of glutamine synthetase among rat liver parenchymal cells in situ and in primary culture. (1983) (353)
Prediction and validation of cell alignment along microvessels as order principle to restore tissue architecture in liver regeneration (2010) (328)
Hepatocyte-specific Smad7 expression attenuates TGF-beta-mediated fibrogenesis and protects against liver damage. (2008) (273)
Tubular overexpression of transforming growth factor-beta1 induces autophagy and fibrosis but not mesenchymal transition of renal epithelial cells. (2010) (266)
New Hepatocyte In Vitro Systems for Drug Metabolism: Metabolic Capacity and Recommendations for Application in Basic Research and Drug Development, Standard Operation Procedures (2003) (264)
Antioxidative and protective properties of extracts from leaves of the artichoke (Cynara scolymus L.) against hydroperoxide-induced oxidative stress in cultured rat hepatocytes. (1997) (259)
Modulation of glutamine metabolism by the PI(3)K–PKB–FOXO network regulates autophagy (2012) (221)
Liver zonation: Novel aspects of its regulation and its impact on homeostasis. (2014) (216)
Inhibition of cholesterol biosynthesis in primary cultured rat hepatocytes by artichoke (Cynara scolymus L.) extracts. (1998) (174)
Differential inhibitory effects of garlic-derived organosulfur compounds on cholesterol biosynthesis in primary rat hepatocyte cultures (1996) (170)
Investigation of the membrane localization and distribution of flavonoids by high-resolution magic angle spinning NMR spectroscopy. (2004) (167)
Conditional tetracycline‐regulated expression of TGF‐β1 in liver of transgenic mice leads to reversible intermediary fibrosis (2003) (154)
Curcumin Inhibits Glyoxalase 1—A Possible Link to Its Anti-Inflammatory and Anti-Tumor Activity (2008) (151)
Primary mouse hepatocytes for systems biology approaches: a standardized in vitro system for modelling of signal transduction pathways. (2006) (139)
Non-linearity of neoplastic conversion induced in rat liver by low exposures to diethylnitrosamine. (1993) (129)
Overexpression of glutamine synthetase is associated with beta-catenin-mutations in mouse liver tumors during promotion of hepatocarcinogenesis by phenobarbital. (2002) (129)
Profibrogenic transforming growth factor‐β/activin receptor–like kinase 5 signaling via connective tissue growth factor expression in hepatocytes (2007) (121)
Protocols for staining of bile canalicular and sinusoidal networks of human, mouse and pig livers, three-dimensional reconstruction and quantification of tissue microarchitecture by image processing and analysis (2014) (121)
Oxidative stress, plant-derived antioxidants and liver fibrosis. (2002) (118)
Hepatocellular expression of glutamine synthetase: an indicator of morphogen actions as master regulators of zonation in adult liver. (2007) (109)
Correlation between β-catenin mutations and expression of Wnt-signaling target genes in hepatocellular carcinoma (2008) (108)
Integrated metabolic spatial‐temporal model for the prediction of ammonia detoxification during liver damage and regeneration (2014) (107)
Multiple inhibitory effects of garlic extracts on cholesterol biosynthesis in hepatocytes (1993) (104)
Antioxidant and hepatoprotective effects of artichoke extracts and constituents in cultured rat hepatocytes. (1997) (104)
Dietary fructose as a risk factor for non-alcoholic fatty liver disease (NAFLD) (2017) (102)
Protective effects of ellagic and chlorogenic acids against oxidative stress in PC12 cells (2005) (100)
Overexpression of glutamine synthetase in human primary liver cancer. (1994) (99)
Heterogeneous distribution of glutamine synthetase during rat liver development. (1987) (98)
Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue (2016) (97)
Model-guided identification of a therapeutic strategy to reduce hyperammonemia in liver diseases. (2016) (95)
Organ patterning in the adult stage: The role of Wnt/β‐catenin signaling in liver zonation and beyond (2009) (95)
Different capacities for amino acid transport in periportal and perivenous hepatocytes isolated by digitonin/collagenase perfusion (1989) (95)
Comparison of antioxidative capacities and inhibitory effects on cholesterol biosynthesis of quercetin and potential metabolites. (2002) (94)
Aldosterone and d-Glucose Stimulate the Proliferation of Human Cardiac Myofibroblasts In Vitro (2002) (93)
Transcription factors ETF, E2F, and SP‐1 are involved in cytokine‐independent proliferation of murine hepatocytes (2010) (92)
A systematic evaluation of the use of physiologically based pharmacokinetic modeling for cross-species extrapolation. (2015) (91)
Inhibition of cholesterol biosynthesis by allicin and ajoene in rat hepatocytes and HepG2 cells. (1994) (91)
Antioxidant properties of silybin glycosides (2002) (90)
“Artificial micro organs”—a microfluidic device for dielectrophoretic assembly of liver sinusoids (2011) (86)
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME (2013) (84)
Inhibition of cholesterol biosynthesis in HepG2 cells by artichoke extracts is reinforced by glucosidase pretreatment (2002) (83)
Permissive effect of dexamethasone on glucagon induction of urea-cycle enzymes in perifused primary monolayer cultures of rat hepatocytes. (1979) (82)
Inhibition of matrix metalloproteinase-2 and -9 activities by selected flavonoids. (2004) (82)
Mathematical modelling of liver regeneration after intoxication with CCl(4). (2007) (81)
Carnosine retards tumor growth in vivo in an NIH3T3-HER2/neu mouse model (2010) (78)
Perifused monolayer cultures of rat hepatocytes as an improved in vitro system for studies on ureogenesis. (1979) (77)
Biliary secretion of sodium fluorescein in primary monolayer cultures of adult rat hepatocytes and its stimulation by nicotinamide. (1982) (73)
Protective effects of flavonoids and two metabolites against oxidative stress in neuronal PC12 cells. (2010) (72)
An improved method for the isolation of hepatocytes from liver slices. Selective removal of Trypan blue-dyeable cells. (1977) (72)
Carnosine inhibits ATP production in cells from malignant glioma (2010) (71)
Effect of garlic powder on C-reactive protein and plasma lipids in overweight and smoking subjects. (2006) (70)
High Circulating Leptin Receptors with Normal Leptin Sensitivity in Liver-specific Insulin Receptor Knock-out (LIRKO) Mice* (2007) (69)
Heterogeneous expression of cholesterol 7 alpha-hydroxylase and sterol 27-hydroxylase genes in the rat liver lobulus. (1995) (66)
Cytochrome P-450-induced cytotoxicity of mitoxantrone by formation of electrophilic intermediates. (1993) (65)
Diethylnitrosamine exposure-responses for DNA damage, centrilobular cytotoxicity, cell proliferation and carcinogenesis in rat liver exhibit some non-linearities. (1996) (65)
Functional Interactions of Cu-ATPase ATP7B with Cisplatin and the Role of ATP7B in the Resistance of Cells to the Drug* (2009) (64)
Zonation of hepatic fatty acid metabolism - The diversity of its regulation and the benefit of modeling. (2015) (63)
Identification and functional characterization of regulatory elements of the glutamine synthetase gene from rat liver. (1993) (63)
Significant amounts of glycogen are synthesized from 3-carbon compounds in astroglial primary cultures from mice with participation of the mitochondrial phosphoenolpyruvate carboxykinase isoenzyme. (1995) (61)
Cadmium, cobalt and lead cause stress response, cell cycle deregulation and increased steroid as well as xenobiotic metabolism in primary normal human bronchial epithelial cells which is coordinated by at least nine transcription factors (2008) (61)
Inhibition of cholesterol biosynthesis by a water-soluble garlic extract in primary cultures of rat hepatocytes. (1991) (61)
The topography of filipin-cholesterol complexes in the plasma membrane of cultured hepatocytes and their relation to cell junction formation. (1982) (58)
Novel Regulatory Mechanisms for Generation of the Soluble Leptin Receptor: Implications for Leptin Action (2012) (58)
FK866-induced NAMPT inhibition activates AMPK and downregulates mTOR signaling in hepatocarcinoma cells. (2015) (58)
Alterations of hepatic enzyme levels and of the acinar distribution of glutamine synthetase in response to experimental liver injury in the rat (1988) (57)
Garlic and health. (2001) (57)
Dose response effects of 2-acetylaminofluorene on DNA damage, cytotoxicity, cell proliferation and neoplastic conversion in rat liver. (1993) (56)
Anticholestatic activity of flavonoids from artichoke (Cynara scolymus L.) and of their metabolites. (2001) (56)
Glycosylation of silybin (1997) (55)
Hedgehog signaling is a potent regulator of liver lipid metabolism and reveals a GLI-code associated with steatosis (2016) (54)
Changes in distribution and activity of glutamine synthetase in carbon tetrachloride‐induced cirrhosis in the rat: Potential role in hyperammonemia (1994) (54)
Glial fibrillary acidic protein as a marker of perisinusoidal stellate cells that can distinguish between the normal and myofibroblast‐like phenotypes (1996) (54)
Induction of glutamine synthetase in periportal hepatocytes by cocultivation with a liver epithelial cell line. (1990) (53)
Antioxidative, Antiproliferative and Biochemical Effects in HepG2 Cells of a Homeopathic Remedy and its Constituent Plant Tinctures Tested Separately or in Combination (2003) (53)
Metabolic and enzymatic characteristics of adult rat liver parenchymal cells in non-proliferating primary monolayer cultures. (1978) (52)
Hormonal regulation of amino acid transport system N in primary cultures of rat hepatocytes. (1987) (51)
Treatment of cirrhotic rats with L-ornithine-L-aspartate enhances urea synthesis and lowers serum ammonia levels. (1997) (51)
The role of growth hormone, dexamethasone and triiodothyronine in the regulation of glutamine synthetase in primary cultures of rat hepatocytes. (1979) (51)
Colocalization of three types of intermediate filament proteins in perisinusoidal stellate cells: glial fibrillary acidic protein as a new cellular marker. (1996) (51)
Heterogeneous expression of glutamine synthetase mRNA in rat liver parenchyma revealed by in situ hybridization and Northern blot analysis of RNA from periportal and perivenous hepatocytes (1988) (49)
Glutamine synthetase heterogeneous expression as a marker for the cellular lineage of preneoplastic and neoplastic liver populations. (1989) (49)
Purification and characterization of rat liver glutaminase. (1987) (48)
Different proliferative activity in vitro of periportal and perivenous hepatocytes. (1988) (48)
Alpha2-macroglobulin inhibits the malignant properties of astrocytoma cells by impeding beta-catenin signaling. (2010) (48)
Nonlinearities in 2-acetylaminofluorene exposure responses for genotoxic and epigenetic effects leading to initiation of carcinogenesis in rat liver. (1998) (47)
Cellular Distribution and Regulation of Glutamine Synthetase in Liver (1984) (45)
Flavonoid binding to a multi-drug-resistance transporter protein: an STD-NMR study (2004) (44)
Hedgehog signaling in glioblastoma multiforme (2012) (42)
Altered acinar distribution of glutamine synthetase and different growth response of cultured enzyme-positive and -negative hepatocytes after partial hepatectomy. (1990) (42)
Synthesis and biological evaluation of new derivatives of emodin. (2004) (41)
Inducible neuronal expression of transgenic TGF‐β1 in vivo: dissection of short‐term and long‐term effects (2005) (41)
Resveratrol Differentially Regulates NAMPT and SIRT1 in Hepatocarcinoma Cells and Primary Human Hepatocytes (2014) (41)
The immunoreactivity of glial fibrillary acidic protein in mesangial cells and podocytes of the glomeruli of rat kidney in vivo and in culture (1998) (41)
Carnosine Inhibits Growth of Cells Isolated from Human Glioblastoma Multiforme (2008) (40)
Hepatocellular heterogeneity in ammonia metabolism: demonstration of limited colocalization of carbamoylphosphate synthetase and glutamine synthetase. (1991) (40)
Heterogeneous (positional) expression of hepatic glutamine synthetase: features, regulation and implications for hepatocarcinogenesis. (1994) (40)
Hepatic Hedgehog signaling contributes to the regulation of IGF1 and IGFBP1 serum levels (2014) (40)
Tissue proteomics by one-dimensional gel electrophoresis combined with label-free protein quantification. (2012) (40)
Comparative in vitro toxicity of seven zinc-salts towards neuronal PC12 cells. (2009) (39)
Glutamine synthetase and hepatocarcinogenesis. (1995) (38)
Different proliferative responses of periportal and perivenous hepatocytes to EGF. (1991) (37)
A method for patterned in situ biofunctionalization in injection-molded microfluidic devices. (2010) (37)
Colocalization of glial fibrillary acidic protein, metallothionein, and MHC II in human, rat, NOD/SCID, and nude mouse skin keratinocytes and fibroblasts. (2007) (37)
Heterogeneity of rat liver parenchyma in cholesterol 7α-hydroxylase and bile acid synthesis (1991) (36)
Drug metabolizing enzyme activities in rat liver epithelial cell lines, hepatocytes and bile duct cells. (1991) (36)
Influence of Liver Fibrosis on Lobular Zonation (2019) (35)
The virtual liver: state of the art and future perspectives (2014) (35)
Glutamate uptake by cultured rat hepatocytes is mediated by hormonally inducible, sodium‐dependent transport systems (1983) (34)
In vitro screening of plant extracts and phytopharmaceuticals: novel approaches for the elucidation of active compounds and their mechanisms. (2000) (34)
Acinar heterogeneity of the epidermal growth factor receptor in the liver of male rats. (1991) (33)
Lessons from Hepatocyte-Specific Cyp51 Knockout Mice: Impaired Cholesterol Synthesis Leads to Oval Cell-Driven Liver Injury (2015) (33)
Primary cultures of rat hepatocytes as a model system of canalicular development, biliary secretion, and intrahepatic cholestasis. I. Distribution of filipin-cholesterol complexes during de novo formation of bile canaliculi. (1982) (33)
Optimality in the zonation of ammonia detoxification in rodent liver (2015) (33)
Cis-Regulatory Sequences from the First Intron of the Rat Glutamine Synthetase Gene Are Involved in Hepatocyte Specific Expression of the Enzyme (1997) (32)
Enhanced matrix degradation after withdrawal of TGF‐β1 triggers hepatocytes from apoptosis to proliferation and regeneration (2005) (31)
Effects of artichoke leaf extract (ALE) on lipoprotein metabolism in vitro and in vivo (1997) (31)
Cell-cell interactions in the regulation of the expression of hepatic enzymes (1997) (31)
Clearance mechanism of prostate specific antigen and its complexes with alpha2-macroglobulin and alpha1-antichymotrypsin. (1999) (30)
Reduction and expansion of the glutamine synthetase expressing zone in livers from tetracycline controlled TGF-beta1 transgenic mice and multiple starved mice. (2004) (30)
Promotion of preneoplastic foci in rat liver with 2,3,7,8-tetrachlorodibenzo-p-dioxin, 1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin and a defined mixture of 49 polychlorinated dibenzo-p-dioxins. (1994) (30)
A convenient and highly sensitive spectrophotometric assay for tryptophan 2,3-dioxygenase. (1982) (29)
Amplification of palmitate-induced inhibition of cholesterol biosynthesis in cultured rat hepatocytes by garlic-derived organosulfur compounds. (1995) (29)
Disrupting Hepatocyte Cyp51 from Cholesterol Synthesis Leads to Progressive Liver Injury in the Developing Mouse and Decreases RORC Signalling (2017) (29)
The RL-ET-14 cell line mediates expression of glutamine synthetase through the upstream enhancer/promoter region. (2005) (29)
E-cadherin as a reliable cell surface marker for the identification of liver specific stem cells (2007) (28)
Alterations in activity and ultrastructural localization of several phosphatases on the surface of adult rat hepatocytes in primary monolayer culture. (1982) (28)
Identification of Factors Involved in the Anti-Tumor Activity of Carnosine on Glioblastomas Using a Proteomics Approach (2011) (28)
Characterization of chemical-induced sterile inflammation in vitro: application of the model compound ketoconazole in a human hepatic co-culture system (2017) (28)
Long-term expression of foreign genes in normal human epidermal keratinocytes after transfection with lipid/DNA complexes (2001) (27)
An intronic silencer element is responsible for specific zonal expression of glutamine synthetase in the rat liver (2005) (26)
β-Catenin and Yes-Associated Protein 1 Cooperate in Hepatoblastoma Pathogenesis. (2019) (26)
Prevention of taurolithocholate-induced hepatic bile canalicular distortions by HPLC-characterized extracts of artichoke (Cynara scolymus) leaves. (2002) (25)
Selective loss of hormonal induction of glutamate transport in primary cultures of hepatocytes from rats treated with CCl4. (1987) (25)
Hedgehog signalling pathway in adult liver: a major new player in hepatocyte metabolism and zonation? (2013) (25)
Serum IGF-I is not a reliable pharmacodynamic marker of exogenous growth hormone activity in mice. (2011) (25)
Glucocorticoid induced expression of glutamine synthetase in hepatoma cells. (2002) (24)
Studies on fructose metabolism in cultured astroglial cells and control hepatocytes: lack of fructokinase activity and immunoreactivity in astrocytes. (1996) (24)
Dexamethasone restores hormonal inducibility of ornithine decarboxylase in primary cultures of rat hepatocytes. (1985) (24)
A silencer element in the first intron of the glutamine synthetase gene represses induction by glucocorticoids. (2004) (24)
Differential effect of growth factors on growth stimulation and phenotypic stability of glutamine‐synthetase‐positive and ‐negative hepatocytes in primary culture (1986) (23)
Perifusion of co-cultured hepatocytes: optimization of studies on drug metabolism and cytotoxicity in vitro (1996) (23)
Strain- and sex-specific variations in hepatic glutamine synthetase activity and distribution in rats and mice. (2008) (23)
Common myofibroblastic features of newborn rat astrocytes and cirrhotic rat liver stellate cells in early cultures and in vivo (1999) (23)
Primary cultures of rat hepatocytes as a model system of canalicular development, biliary secretion, and intrahepatic cholestasis. III. Properties of the biliary transport of immunoglobulin A revealed by immunofluorescence. (1983) (22)
Hedgehog signalling in myeloid cells impacts on body weight, adipose tissue inflammation and glucose metabolism (2017) (22)
Heterogeneous hepatocellular expression of glutamine synthetase in developing mouse liver and in testicular transplants of fetal liver. (1995) (22)
Fuzzy modeling reveals a dynamic self-sustaining network of the GLI transcription factors controlling important metabolic regulators in adult mouse hepatocytes. (2015) (21)
Variable influence of kaempferol and myricetin on in vitro hepatocellular cholesterol biosynthesis. (2003) (21)
Amino acid transport in established adult rat liver epithelial cell lines (1986) (21)
Dual luciferase assay for secreted luciferases based on Gaussia and NanoLuc. (2013) (21)
Liver-Restricted Repin1 Deficiency Improves Whole-Body Insulin Sensitivity, Alters Lipid Metabolism, and Causes Secondary Changes in Adipose Tissue in Mice (2014) (21)
Acquisition of blood–tissue barrier–supporting features by hepatic stellate cells and astrocytes of myofibroblastic phenotype. Inverse dynamics of metallothionein and glial fibrillary acidic protein expression (2001) (20)
Different proliferative responses of periportal and pericentral rat hepatocytes to hepatocyte growth factor. (1995) (20)
Differential effect of growth factors on growth stimulation and phenotypic stability of glutamine-synthetase-positive and -negative hepatocytes in primary culture. (1986) (20)
Surface Modification of Polyethylene by Plasma Grafting with Styrene for Enhanced Biocompatibility (1997) (20)
Influence of organosulphur compounds from garlic on the secretion of matrix metalloproteinases and their inhibitor TIMP-1 by cultured HUVEC cells (2004) (19)
From teratogens to potential therapeutics: natural inhibitors of the Hedgehog signaling network come of age. (2009) (19)
Differential inhibition of matrix metalloproteinases-2, -9, and -13 activities by selected anthraquinones. (2009) (19)
Influence of biotransformation of luteolin, luteolin 7-O-glucoside, 3',4'-dihydroxyflavone and apigenin by cultured rat hepatocytes on antioxidative capacity and inhibition of EGF receptor tyrosine kinase activity. (2006) (19)
Oleate ameliorates palmitate-induced reduction of NAMPT activity and NAD levels in primary human hepatocytes and hepatocarcinoma cells (2017) (19)
Cell proliferation in the livers of male mice and rats exposed to the carcinogen P-dichlorobenzene: evidence for thresholds. (1998) (18)
Hepatic expression of glutamine synthetase in rats is controlled by STAT5 and TCF transcription factors (2006) (18)
Influence of hormones and drugs on glutathione-S-transferase levels in primary culture of adult rat hepatocytes (1990) (18)
Primary culture of rat hepatocytes as a model system of canalicular development, biliary secretion, and intrahepatic cholestasis (1983) (18)
Response of sinusoidal mouse liver cells to choline-deficient ethionine-supplemented diet (2010) (17)
CHOLERETIC AND ANTICHOLESTATIC ACTIVITIES OF FLAVONOIDS OF ARTICHOKE (CYNARA CARDUNCULUS L. SUBSP. SCOLYMUS (L.) HAYEK) (2005) (17)
The extended TILAR approach: a novel tool for dynamic modeling of the transcription factor network regulating the adaption to in vitro cultivation of murine hepatocytes (2012) (17)
Reestablishment of the heterogeneous distribution of hepatic glutamine synthetase during regeneration after CCl4-intoxication (2004) (17)
Central energy metabolism remains robust in acute steatotic hepatocytes challenged by a high free fatty acid load. (2012) (17)
Phosphatidylcholine dimers can be easily misinterpreted as cardiolipins in complex lipid mixtures: a matrix-assisted laser desorption/ionization time-of-flight mass spectrometric study of lipids from hepatocytes. (2011) (16)
Identification of a cis-acting element and a novel trans-acting factor of the glutamine synthetase gene in liver cells. (2001) (16)
Isolation of periportal and pericentral hepatocytes. (1998) (16)
Different proliferative potential of rat and pig hepatocytes in pure primary culture and coculture. (1992) (16)
Prevention of cadmium-induced toxicity in liver-derived cells by the combination preparation Hepeel(®). (2009) (16)
Comparison of uptake and neuroprotective potential of seven zinc-salts (2010) (16)
Inhibition by gonadectomy of effects of 2-acetylaminofluorene in livers of male, but not female rats. (1993) (15)
Different drug metabolizing capacities in cultured periportal and pericentral hepatocytes. (1994) (15)
Dioxin mediates downregulation of the reduced folate carrier transport activity via the arylhydrocarbon receptor signalling pathway. (2010) (14)
Stereological assessment of sexual dimorphism in the rat liver reveals differences in hepatocytes and Kupffer cells but not hepatic stellate cells (2016) (14)
Keratinocytes as Depository of Ammonium-Inducible Glutamine Synthetase: Age- and Anatomy-Dependent Distribution in Human and Rat Skin (2009) (13)
The Wnt/β‐catenin pathway determines the predisposition and efficiency of liver‐to‐pancreas reprogramming (2018) (13)
Tick-tock hedgehog-mutual crosstalk with liver circadian clock promotes liver steatosis. (2019) (13)
Heterogeneity of rat liver parenchyma in cholesterol 7 alpha-hydroxylase and bile acid synthesis. (1991) (13)
Specific chromosomal abnormalities characterize four established cell lines derived from malignant human gliomas (2004) (13)
Correction: α 2-Macroglobulin Inhibits the Malignant Properties of Astrocytoma Cells by Impeding β -Catenin Signaling (2010) (12)
Transient transfection of primary cultured hepatocytes using CaPO4/DNA precipitation. (1996) (12)
Cell‐cell interactions: Clues to hepatocyte heterogeneity and beyond? (1992) (12)
Oval cell proliferation in p16INK4a expressing mouse liver is triggered by chronic growth stimuli (2007) (12)
4-Aminoethylamino-emodin – a novel potent inhibitor of GSK-3β– acts as an insulin-sensitizer avoiding downstream effects of activated β-catenin (2009) (12)
Hepatic autophagy is differentially regulated in periportal and pericentral zones - a general mechanism relevant for other tissues? (2013) (12)
Primary cultures of rat hepatocytes as a model system of canalicular development, biliary secretion, and intrahepatic cholestasis. II. Taurolithocholate-induced alterations of canalicular morphology and of the distribution of filipin-cholesterol complexes. (1982) (12)
Primary cultures of rat hepatocytes as a model system of canalicular development, biliary secretion, and intrahepatic cholestasis. IV. Disintegration of bile canaliculi and disturbance of tight junction formation caused by vinblastine. (1983) (11)
The Diurnal Timing of Starvation Differently Impacts Murine Hepatic Gene Expression and Lipid Metabolism – A Systems Biology Analysis Using Self-Organizing Maps (2018) (11)
Glutamate uptake in primary cultures of biliary epithelial cells from normal rat liver (1991) (11)
Sequential Functional and Morphological Alterations During Hepatocarcinogenesis Induced in Rats by Feeding of a Low Dose of 2-Acetylaminofluorene (1994) (11)
Mutual Zonated Interactions of Wnt and Hh Signaling Are Orchestrating the Metabolism of the Adult Liver in Mice and Human. (2019) (11)
Ligand-dependent redistribution of the IgA receptor on cultured rat hepatocytes and its disturbance by cytochalasin B. (1987) (11)
A Novel Model of Fibroblast‐Mediated Cartilage Destruction (2005) (11)
Post-transcriptional inhibition of glutamine synthetase induction in rat liver epithelial cells exerted by conditioned medium from rat hepatocytes. (2000) (10)
The spontaneous induction of glutamine synthetase in pig hepatocytes cocultured with RL-ET-14 cells is completely inhibited by trijodothyronine and okadaic acid. (1998) (10)
Disappearance of visible bile canaliculi caused by vinblastine in primary cultures of rat hepatocytes. (1983) (10)
Decreased fibronectin in rat liver altered foci and adenomas induced by N-2-fluorenylacetamide. (1988) (10)
Conditional loss of hepatocellular Hedgehog signaling in female mice leads to the persistence of hepatic steroidogenesis, androgenization and infertility (2017) (10)
Garlic and Cardiovascular Diseases (2007) (9)
The many faces of Hedgehog signalling in the liver: recent progress reveals striking cellular diversity and the importance of microenvironments. (2014) (9)
Glycosylation of Silybin. (1997) (9)
Improved Determination of Drug Metabolism by Perifusion of Recombinant V79 Cells Carrying Human CYP3A4. (1999) (9)
Heterogeneous distribution of the epidermal growth factor receptor in rat liver parenchyma. (1992) (9)
Screening, Surveillance, and Primary Prevention for Colorectal Cancer: A Review of the Recent Literature (2009) (9)
Cellular characteristics of epithelial cell lines from juvenile rat liver: selective induction of glutamine synthetase by dexamethasone (1998) (9)
Dual origin, development, and fate of bovine pancreatic islets (2013) (8)
Induction of glutamine synthetase and transient co-expression with carbamoylphosphate synthetase in hepatocytes transplanted into fat pads of syngeneic hosts (2004) (8)
Heterogeneous expression of suppressor of cytokine signalling 2 (SOCS‐2) in liver tissue (2009) (8)
Heterogeneous intrahepatic distribution of glutamine synthetase. (1990) (8)
Speeding up hepatocyte proliferation: How triiodothyronine and β‐catenin join forces (2014) (8)
Tailoring microfluidic systems for organ-like cell culture applications using multiphysics simulations (2013) (8)
Citric acid as the last therapeutic approach in an acute life-threatening metabolic decompensation of propionic acidaemia (2013) (7)
Dynamics of glial fibrillary acidic protein distribution in cultured glomerular podocytes and mesangial cells of the rat kidney (1999) (7)
Co-cultivation of liver epithelial cells with hepatocytes. (2002) (7)
Reactivity of lipophilic diSchiff-Base coordinated copper in rat hepatocytes. (1996) (7)
Dynamic Network Reconstruction from Gene Expression Data Describing the Effect of LiCl Stimulation on Hepatocytes (2005) (7)
Towards knowledge-driven cross-species extrapolation (2016) (6)
Heterogeneity of rat liver parenchyma in taurocholate uptake. (2003) (6)
Heterogeneous carbamoylphosphate synthetase I expression in testicular transplants of fetal mouse liver. (1998) (6)
Enhanced sensitivity of perifused primary rat hepatocytes to mitogens and growth modulation by carcinogens. (1995) (6)
Complementary expression of glutamine synthetase and carbamoylphosphate synthetase I in ornithine carbamoyltransferase-deficient mouse liver (spf–ash mouse) (1997) (6)
Immunohistochemical localization of glutamine synthetase in human liver (1989) (6)
Hormonal Control of Amino Acid Transport Systems in Cultured Periportal and Perivenous Hepatocytes (1989) (6)
The oxidative biotransformation of losoxantrone (CI-941). (2002) (6)
Global Increase of p16INK4a in APC-Deficient Mouse Liver Drives Clonal Growth of p16INK4a-Negative Tumors (2014) (6)
INHIBITION OF CHOLESTROL BIOSYNTHESIS IN PRIMARY CULTURES RAT HEPATOCYTES BY ARTICHOKE (CYNARA SCOLYMUS L.) EXTRACT (1998) (5)
Dehydroepiandrosterone increases in zone of glutamine synthetase-positive hepatocytes in female rat liver: a putative androgenic effect (1999) (5)
Heterogeneous expression of mRNA in rat liver lobules as detected by differential display (2000) (5)
Histochemical approaches to the screening of carcinogens in vitro. (1991) (5)
Garlic: the key to sophisticated lowering of hepatocellular lipid. (1997) (5)
Antifibrotic Effects of Amyloid-Beta and Its Loss in Cirrhotic Liver (2020) (5)
Sensitive detection of growth stimulating tumour promoters in perifused primary rat hepatocyte cultures. (1997) (4)
Perifusion culture of hepatocytes. (1998) (4)
Zonal gene expression in murine liver: Are tumors helping us to solve the mystery? (2006) (4)
Spermidine level and protein synthesis are coregulated in nonproliferating hepatocytes. (1989) (4)
Stimulation of acid secretion by extracts of Gentiana lutea L. in cultured cells from rat gastric mucosa (1997) (4)
Dehydroepiandrosterone increases the zone [correction of in zone] of glutamine synthetase-positive hepatocytes in female rat liver: a putative androgenic effect. (1999) (4)
Conditioned medium from cultured rat hepatocytes completely blocks induction of glutamine synthetase by dexamethasone in several rat liver epithelial cell lines (1998) (4)
Influence of Traumeel on cultured chondrocytes and recombinant human matrix metalloproteinases: Implications for chronic joint diseases (2009) (4)
HepaChip-MP - a twenty-four chamber microplate for a continuously perfused liver coculture model. (2020) (4)
A 2-compartment model of glutamine and ammonia metabolism in liver tissue (2007) (4)
Monoclonal antibodies directed against rat liver epithelial cell lines selectively recognize bile duct epithelium in livers of adult rats (1988) (4)
Expression of glial fibrillary acidic protein in the rat endocard, cardiac interstitial Cajal-like cells, and perivascular structures of the spleen (2008) (4)
Towards Artificial Liver Sinusoids by Dielectrophoretic Cell Assembly in Microfluidic System for Use in Substance Screening (2009) (4)
Combination of Hemodialysis and Hemoperfusion in a Single Hollow-Fiber Unit for Treatment of Uremia (1978) (4)
Cyclopamine and Rapamycin Synergistically Inhibit mTOR Signalling in Mouse Hepatocytes, Revealing an Interaction of Hedgehog and mTor Signalling in the Liver (2020) (4)
Dynamic Model of Amino Acid and Carbohydrate Metabolism in Primary Human Liver Cells (2006) (3)
Correction: Curcumin Inhibits Glyoxalase 1—A Possible Link to Its Anti-Inflammatory and Anti-Tumor Activity (2011) (3)
Intercellular Compartmentation of Hepatic Ammonia Metabolism: A Basis for the Differential Regulatory Influence of Hormones on Related Enzymes and Amino Acid Transport Systems? (1984) (3)
Inactivation of lactate dehydrogenase during freezing in the presence of metyrapone : Implications for in vitro cytotoxicity studies (2000) (3)
Inhibition of cholesterol-biosynthesis in cultured hepatocytes by garlic components (1993) (3)
Model-based optimization to explain liver zonation in nitrogen metabolism (2010) (3)
TRANSFECTION OF NORMAL HUMAN EPIDERMAL KERATINOCYTES WITH LIPID/DNA COMPLEXES IN VITRO (2001) (2)
[Treatment of cutaneous and cutaneously metastasizing malignant neoplasms using massive doses of antineoplastic agents]. (1972) (2)
Differential and stereoselective in vitro cytotoxicity of eremophilane sesquiterpenes of Petasites hybridus rhizomes in rat hepatocytes. (2011) (2)
Correction: Keratinocytes as Depository of Ammonium-Inducible Glutamine Synthetase: Age- and Anatomy-Dependent Distribution in Human and Rat Skin (2009) (2)
Promotion of hepatocarcinogenesis is mediated by overexpression of glutamine synthetase in beta-catenine-mutated mouse liver tumors (2002) (2)
DEVELOPMENT OF BILIARY MEMBRANE DIFFERENTIATION IN CULTURED HEPATOCYTES (1981) (1)
Continous, non-invasive monitoring of oxygen consumption in a parallelized microfluidic in vitro system provides novel insight into the response to nutrients and drugs of primary human hepatocytes (2022) (1)
Hepatic Hedgehog Signaling Participates in the Crosstalk between Liver and Adipose Tissue in Mice by Regulating FGF21 (2022) (1)
Altered capacities for amino acid transport in response to liver injury by CC14 and during subsequent regeneration (1990) (1)
International Congress on Hepatocytes-Applications in Cell Biology, Toxicology and Medicine (2004) (1)
Model predicts fundamental role of biomechanical control of cell cycle progression during liver regeneration after partial hepatectomy. (2020) (1)
Obtaining of Monoclonal Antibodies by Means of DNA Immunization (2001) (1)
Contents Vol. 18, 1996 (2004) (1)
Participation of microtubules and microfilaments in the transcellular biliary secretion of immunoglobulin A in primary cultures of rat hepatocytes (1984) (1)
Hepatic Hedgehog signaling contributes to the regulation of IGF1 and IGFBP1 serum levels (2014) (1)
Liposomes as carriers: not as innocent as one would like (2015) (1)
[Studies on the systemic effect of extensively applied topical steroids]. (1972) (1)
12 Animal Models for Studies on Liver Regeneration (2011) (1)
Glutamine and Autophagy (2017) (1)
Liver regeneration after intoxication with CCl4: Spatial–temporal mathematical modelling in triple transgenic mice (2007) (1)
["Collagen-like protein" content in serum of psoriatics]. (1970) (0)
Rolle von β-Catenin bei der Regulation der Glutaminsynthetase in Hepatocyten und HepG2 Zellen (2004) (0)
Cytochrome P-450-induced Cytotoxicity of Mitoxantrone by Formation of Electrophilic Intermediates1 (2006) (0)
Phyllanthus use for the treatment of chronic fibrotic and inflammatory processes. (2000) (0)
Regulation of energy metabolism in hepatocytes with induced steatosis (2015) (0)
374 Transgenic Expression of R122H_hPRSS1 Aggravates Experimental Pancreatitis in BALB/C Mice (2009) (0)
Novel insights in the cross-talk of Ppar+ (2013) (0)
A quantitative metabolomic profiling and corresponding modeling approach of hepatocytes with activated Wnt/ß-Catenin signaling (2015) (0)
[Secondary gout in skin diseases]. (1967) (0)
The emerging realm of morphogens in the adult liver of mice and human – a deep insight into distribution, interaction and regulation (2018) (0)
Hepatic autophagy is differentially regulated in periportal and pericentral zones - a general mechanism relevant for other tissues? (2013) (0)
The lipogenic transcription factors Pparα and Pparγ as possible linkage between lipid metabolism and Hedgehog-Signalling Pathway? (2014) (0)
Cross-linking of liver metabolism - hedgehog as a key regulator of energy metabolism, regulating mechanistic target of rapamycin activity (2020) (0)
Die Rolle von β-Catenin-Mutationen für die Expression der Glutaminsythetase in hepatozellulären Karzinomen (2006) (0)
[Universal acute toxic epidermolysis (Lyell's syndrome)]. (1970) (0)
Liposomes as carriers: not as innocent as one would like (2015) (0)
Cooperation of Hedgehog and Wnt/β-Catenin signalling in regulation of steroidogenesis in the liver (2015) (0)
TICK-TOCK-HEDGEHOG: Hedgehog signalling controls the liver circadian clock and vice versa (2014) (0)
Forthcoming conferences (2010) (0)
A new modelling approach for Gli transcription factor network in hepatocytes (2015) (0)
Scotland's Rural College Stereological assessment of sexual dimorphism in the rat liver reveals differences in hepatocytes and Kupffer cells but not hepatic stellate cells (2018) (0)
MALDI-imaging: a tool to study lipid distribution in liver tissue during regeneration (2010) (0)
The effect of leptin and insulin on free fatty acid (FFA)-induced steatosis in primary mouse hepatocytes (2013) (0)
P89 Recombinant human GH stimulates IGF-I mRNA expression and secretion in hepatocytes of C57BL/6 mice in vitro, but not in vivo (2010) (0)
Increased CTGF expression occurs in human and mouse hepatocytes of damaged livers and is mediated by TGF-β signaling (2007) (0)
Use of the opposite cell differentiation program (OCDP) for the treatment of degenerated, properties under pathological condition organs (2007) (0)
Effect of Hyper-IL-6 on cultured primary mouse hepatocytes (2005) (0)
Differentielle Regulation von Akutphase Genen in primären Hepatozyten durch Interleukin–6 (2006) (0)
Profibrogenic TGF-beta/ALK5 signaling via CTGF expression in hepatocytes (2007) (0)
Dietary fructose as a risk factor for non-alcoholic fatty liver disease (NAFLD) (2016) (0)
The role of Suppressor of Fused in the regulation of Hedgehog and Wnt/ß-Catenin signaling pathway in adult liver (2012) (0)
Liver epithelial cell culture. (2002) (0)
[On the effectiveness of highly concentrated fluocinolone acetonide cream in various skin diseases]. (1969) (0)
Author response: Hedgehog signaling is a potent regulator of liver lipid metabolism and reveals a GLI-code associated with steatosis (2016) (0)
[Studies on the plasma DHEA content of psoriasis patients]. (1970) (0)
Wnt-signaling gradients and their impact on liver parenchymal heterogeneity – a link to xenobiotic metabolism (2014) (0)
Inhibition of eholesterol-biosynthesis in eultured hepatoeytes by garlie eomponents (1993) (0)
In vitro evaluation of the cytotoxicity of several eremophilane constituents of Petasites hybridus in rat hepatocytes (2007) (0)
[On the distribution of the LDH isoenzyme in serum of patients with psoriasis]. (1968) (0)
The major findings of the garlic & health project (2005) (0)
1277 SECRET MISSION OF MORPHOGENS IN ADULT LIVER – NEW INSIGHTS IN METABOLIC CONTROL BY Wnt AND Hedgehog SIGNALING (2013) (0)
Subject Index Vol. 18, 1996 (1996) (0)
Liver regeneration after intoxication with CCl4: spatial-temporal mathematical modelling in triple transgenic mice (2008) (0)
The hedgehog effect: mediating crosstalk between liver and adipose tissue (2020) (0)
Hedgehog around the clock (2012) (0)
Regulation of Hepatic Glutamine and Ammonia Metabolism by Morphogens (2017) (0)
Optimality in the zonation of ammonia detoxification in rodent liver (2015) (0)
Formation of Electrophilic Intermediates Cytochrome P-450-induced Cytotoxicity of Mitoxantrone by Updated Version (2006) (0)
TGF-beta and hepatocyte transdifferentiation in liver fibrogenesis (2007) (0)
3D in vitro reconstruction of synthetic liver sinusoids in a microfluidic cell culture device (2013) (0)
6 Regulation of Hepatic Glutamine and Ammonia Metabolism by Morphogens (2017) (0)
Hyper-Interleukin-6 dependent changes in normal and regenerating mouse livers (2013) (0)
P1219 : Hepatic hedgehog signaling and steroidogenesis -an evil partnership? (2015) (0)
CR Kahn High Circulating Leptin Receptors with Normal Leptin Sensitivity in Liver-Specific Insulin Receptor Knockout ( LIRKO ) Mice (2007) (0)
P0930 : Lessons from hepatocyte-specific CYP51 knockout mice: Impaired cholesterol synthesis leads to NASH-like oval cell driven liver injury (2015) (0)
Regulatory modules of miRNA and transcription factors affect gene expression in cultivated hepatocytes (2011) (0)
Feedback inhibition of apolipoprotein A-I synthesis by its propeptide in hepatocyte cell culture and in the cell-free system (2017) (0)
Global Increase of p 16 INK 4 a in APC-De fi cient Mouse Liver Drives Clonal Growth of p 16 INK 4 a-Negative Tumors (2014) (0)
Influence of Carbon Chain Length on Formation and Composition of Triglycerides in Free Fatty Acid- induced Steatosis (2014) (0)
alpha 2-Macroglobulin Inhibits the Malignant Properties of Astrocytoma Cells by Impeding beta-Catenin Signaling (vol 70, pg 277, 2010) (2010) (0)
Up and Down of Hedgehog Signaling leads to Down and Up of Steroidogenesis in the Liver (2015) (0)
Negative Tumors (2017) (0)
The role of detoxification and drainage in integrative medicine: A modern, scientific approach, using basic and clinical research on a homeopathic medicine as an illustration (2008) (0)
Poster Session 1 (2009) (0)
Wnt-signaling and glutamine synthetase expression in human hepatocellular carcinomas (2007) (0)
Characterization of chemical-induced sterile inflammation in vitro: application of the model compound ketoconazole in a human hepatic co-culture system (2016) (0)
Integrated metabolic and spatial-temporal modelling identified a novel mechanism of ammonia detoxification (2014) (0)
Improved Drug Metabolizing Capacity of Hepatocytes Co‐Cultured with Epithelial Cells and Maintained in a Perifusion System (2008) (0)
Use of Phyllanthus for treating oxidative stress and other symptoms (1999) (0)
Erratum to “Heterogeneity of rat liver parenchyma in taurocholate uptake” [Hepatol. Res. 27 (3) (2003) 238–247] (2004) (0)
Ueberham et al . Comparative Hepatology 2010 (2014) (0)
Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue (2016) (0)
TGF-b drives hepatic progenitor cell activation during liver damage (2009) (0)
Use of luteolin-7-O-glucuronide as an active ingredient in an anticholestatic drug (2000) (0)
Poster and Lecture Abstracts (2004) (0)
4-Aminoethylaminoemodin als neuer Inhibitor der Glykogensynthasekinase-3β mit viel versprechenden Eigenschaften (2010) (0)
A Microfluidic 3D Hepatocyte Culture System -HepaChip®- For Drug And Toxicity Investigations (2012) (0)
Resveratrol differentially regulates NAMPT and SIRT1 in hepatocarcinoma cells and primary human hepatocytes (2014) (0)
Protocols for staining of bile canalicular and sinusoidal networks of human, mouse and pig livers, three-dimensional reconstruction and quantification of tissue microarchitecture by image processing and analysis (2014) (0)
Su2066 Tissue Remodelling and Ammonia Detoxification in Atp7b-/-Mice a Model for Wilson Disease (2012) (0)
[Massive-dose cytostatic therapy of malignant skin neoplasms and of malignant neoplasms with skin metastases]. (1972) (0)
[Steroids and skin. V. Plasma dehydroepiandrosterone and erythrocyte glucose-6-phosphate dehydrogenase activity in psoriatic patients before and after the administration of dehydroepiandrosterone sulfate]. (1971) (0)
Dynamics of glial fibrillary acidic protein distribution in cultured glomerular podocytes and mesangial cells of the rat kidney. (1999) (0)
Conditional loss of hepatocellular Hedgehog signaling in female mice leads to the persistence of hepatic steroidogenesis, androgenization and infertility (2017) (0)
P0921 : Male prevalence and features of advanced NASH with cirrhosis in the liver knockout of CYP51 from cholesterol synthesis (2015) (0)
Oleate ameliorates palmitate-induced reduction of NAMPT activity and NAD levels in primary human hepatocytes and hepatocarcinoma cells (2017) (0)
Impact of kava cultivar, plant part and extraction medium on in-vitro cytotoxicity of kava (Piper methysticum) in HepG2 and Hep3B cells (2006) (0)
Unravelling the role of the Hedgehog siganlling pathway in the hepato-ovarian axis (2018) (0)
Hedgehog signalling pathway is involved in the regulation of circadian rhythm within hepatic lipid metabolism (2013) (0)
808 - Hedgehog Signaling Directly Regulates Metabolism and Proliferation in Hepatocytes and is Critical for Normal Liver Regeneration Following Partial Hepatectomy in Mice (2018) (0)
Cultivation of primary hepatocytes induces an inflammation-cholestasis response that resembles features of in vivo inflammation during damage and regeneration (2012) (0)
A silencer element in the first intron of the glutamine synthetase gene and its role in hepatocellular expression (2004) (0)
New Results - Tissue growth, regeneration and cell movment (2008) (0)
[358] ZONATION OF ADULT LIVER IS CONTROLLED BY MORPHOGENS ON DIFFERENT LEVELS OF HEPATOCELLULAR GENE EXPRESSION (2007) (0)
HEDGEHOG AROUND THE CLOCK: Mutual interaction between circadian rhythms of hepatic lipid metabolism and hedgehog morphogen pathway (2013) (0)

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