Roman Dziarski
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Polish-American microbiologist and immunologist
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Roman Dziarskibiology Degrees
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Microbiology
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Immunology
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Biology
Roman Dziarski's Degrees
- PhD Microbiology University of Warsaw
- Doctorate Immunology University of Warsaw
Why Is Roman Dziarski Influential?
(Suggest an Edit or Addition)According to Wikipedia, Roman Dziarski is a Polish-born American immunologist and microbiologist. He is best known for his research on innate immunity and bacterial peptidoglycan, for discovering the family of human peptidoglycan recognition proteins, which comprises PGLYRP1, PGLYRP2, PGLYRP3, and PGLYRP4, and for defining the functions of these proteins.
Roman Dziarski's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Peptidoglycan- and Lipoteichoic Acid-induced Cell Activation Is Mediated by Toll-like Receptor 2* (1999) (1941)
- Cutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2. (1999) (1401)
- The peptidoglycan recognition proteins (PGRPs) (2006) (394)
- Peptidoglycan recognition proteins: pleiotropic sensors and effectors of antimicrobial defences (2007) (393)
- A Subset of Toll-Like Receptor Ligands Induces Cross-presentation by Bone Marrow-Derived Dendritic Cells1 (2003) (333)
- Peptidoglycan recognition proteins: modulators of the microbiome and inflammation (2011) (313)
- Peptidoglycan Recognition Proteins (2001) (307)
- Binding of Bacterial Peptidoglycan to CD14* (1998) (286)
- Peptidoglycan recognition proteins (PGRPs). (2004) (264)
- Staphylococcus aureus Peptidoglycan Is a Toll-Like Receptor 2 Activator: a Reevaluation (2005) (245)
- CD14 Is a Cell-activating Receptor for Bacterial Peptidoglycan* (1996) (240)
- MD-2 Enables Toll-Like Receptor 2 (TLR2)-Mediated Responses to Lipopolysaccharide and Enhances TLR2-Mediated Responses to Gram-Positive and Gram-Negative Bacteria and Their Cell Wall Components1 (2001) (238)
- Human Peptidoglycan Recognition Protein-L Is an N-Acetylmuramoyl-L-alanine Amidase* (2003) (234)
- Chemokines Are the Main Proinflammatory Mediators in Human Monocytes Activated by Staphylococcus aureus, Peptidoglycan, and Endotoxin* (2000) (218)
- Mammalian Peptidoglycan Recognition Protein Binds Peptidoglycan with High Affinity, Is Expressed in Neutrophils, and Inhibits Bacterial Growth* (2000) (217)
- Peptidoglycan Recognition Proteins Are a New Class of Human Bactericidal Proteins* (2006) (215)
- Micrococci and Peptidoglycan Activate TLR2→MyD88→IRAK→TRAF→NIK→IKK→NF-κB Signal Transduction Pathway That Induces Transcription of Interleukin-8 (2001) (198)
- Pglyrp-Regulated Gut Microflora Prevotella falsenii, Parabacteroides distasonis and Bacteroides eggerthii Enhance and Alistipes finegoldii Attenuates Colitis in Mice (2016) (194)
- Recognition of bacterial peptidoglycan by the innate immune system (2003) (190)
- Soluble peptidoglycan-induced monokine production can be blocked by anti-CD14 monoclonal antibodies and by lipid A partial structures (1994) (189)
- Defect in neutrophil killing and increased susceptibility to infection with nonpathogenic gram-positive bacteria in peptidoglycan recognition protein-S (PGRP-S)-deficient mice. (2003) (181)
- Isolation of peptidoglycan and soluble peptidoglycan fragments. (1994) (172)
- Specific binding of soluble peptidoglycan and muramyldipeptide to CD14 on human monocytes (1997) (159)
- Review: Mammalian peptidoglycan recognition proteins (PGRPs) in innate immunity (2010) (150)
- Zebrafish peptidoglycan recognition proteins are bactericidal amidases essential for defense against bacterial infections. (2007) (121)
- Human Peptidoglycan Recognition Proteins Require Zinc to Kill Both Gram-Positive and Gram-Negative Bacteria and Are Synergistic with Antibacterial Peptides1 (2007) (119)
- Peptidoglycan recognition proteins protect mice from experimental colitis by promoting normal gut flora and preventing induction of interferon-gamma. (2010) (119)
- Differential activation of extracellular signal-regulated kinase (ERK) 1, ERK2, p38, and c-Jun NH2-terminal kinase mitogen-activated protein kinases by bacterial peptidoglycan. (1996) (116)
- Peptidoglycan Recognition Proteins A NOVEL FAMILY OF FOUR HUMAN INNATE IMMUNITY PATTERN RECOGNITION MOLECULES* (2001) (112)
- Mammalian PGRPs: novel antibacterial proteins (2006) (112)
- Preferential induction of autoantibody secretion in polyclonal activation by peptidoglycan and lipopolysaccharide. I. In vitro studies. (1982) (106)
- Peptidoglycan induces transcription and secretion of TNF-alpha and activation of lyn, extracellular signal-regulated kinase, and rsk signal transduction proteins in mouse macrophages. (1995) (101)
- Interactions of CD14 with components of gram-positive bacteria. (2000) (99)
- Autoimmunity: polyclonal activation or antigen induction? (1988) (95)
- Peptidoglycan recognition proteins kill bacteria by activating protein-sensing two-component systems (2011) (91)
- PGLYRP-2 and Nod2 are both required for peptidoglycan-induced arthritis and local inflammation. (2009) (91)
- Lipopolysaccharide and peptidoglycan: CD14-dependent bacterial inducers of inflammation. (1998) (89)
- Peptidoglycan Recognition Proteins Kill Bacteria by Inducing Oxidative, Thiol, and Metal Stress (2014) (88)
- Peptidoglycan Recognition Proteins kill bacteria by inducing suicide through protein-sensing two-component systems (2011) (84)
- Bacterial Peptidoglycan Induces CD14-dependent Activation of Transcription Factors CREB/ATF and AP-1* (1999) (83)
- Bacterial Peptidoglycan-Induced tnf-α Transcription Is Mediated Through the Transcription Factors Egr-1, Elk-1, and NF-κB1 (2001) (79)
- Peptidoglycan recognition in innate immunity. (2005) (74)
- Role of MD-2 in TLR2- and TLR4-mediated recognition of Gram-negative and Gram-positive bacteria and activation of chemokine genes (2000) (74)
- Peptidoglycan and lipopolysaccharide bind to the same binding site on lymphocytes. (1991) (68)
- Identification of serum N-acetylmuramoyl-l-alanine amidase as liver peptidoglycan recognition protein 2. (2005) (68)
- Cell-bound albumin is the 70-kDa peptidoglycan-, lipopolysaccharide-, and lipoteichoic acid-binding protein on lymphocytes and macrophages. (1994) (62)
- Role of MD-2 in TLR2- and TLR4-mediated recognition of Gram-negative and Gram-positive bacteria and activation of chemokine genes. (2000) (60)
- Demonstration of peptidoglycan-binding sites on lymphocytes and macrophages by photoaffinity cross-linking. (1991) (59)
- Peptidoglycan Recognition Protein 2 (N-Acetylmuramoyl-l-Ala Amidase) Is Induced in Keratinocytes by Bacteria through the p38 Kinase Pathway (2005) (53)
- Polyclonal activation of immunoglobulin secretion in B lymphocytes induced by staphylococcal peptidoglycan. (1980) (51)
- Differential Effects of Peptidoglycan Recognition Proteins on Experimental Atopic and Contact Dermatitis Mediated by Treg and Th17 Cells (2011) (47)
- Mitogenic activity of staphylococcal peptidoglycan (1979) (44)
- Bactericidal peptidoglycan recognition protein induces oxidative stress in Escherichia coli through a block in respiratory chain and increase in central carbon catabolism (2017) (40)
- Bacterial peptidoglycan-induced tnf-alpha transcription is mediated through the transcription factors Egr-1, Elk-1, and NF-kappaB. (2001) (39)
- Mammalian peptidoglycan recognition proteins kill bacteria by activating two-component systems and modulate microbiome and inflammation. (2012) (39)
- Peptidoglycan Recognition Protein 1 Enhances Experimental Asthma by Promoting Th2 and Th17 and Limiting Regulatory T Cell and Plasmacytoid Dendritic Cell Responses (2013) (39)
- Soluble CD14 Enhances Membrane CD14-Mediated Responses to Peptidoglycan: Structural Requirements Differ from Those for Responses to Lipopolysaccharide (2000) (38)
- Endothelial and epithelial cells do not respond to complexes of peptidoglycan with soluble CD14 but are activated indirectly by peptidoglycan-induced tumor necrosis factor-alpha and interleukin-1 from monocytes. (1998) (38)
- Peptidoglycan recognition in innate immunity (2005) (37)
- Nod2 and Nod2-regulated microbiota protect BALB/c mice from diet-induced obesity and metabolic dysfunction (2017) (36)
- Peptidoglycan Recognition Protein Pglyrp2 Protects Mice from Psoriasis-like Skin Inflammation by Promoting Regulatory T Cells and Limiting Th17 Responses (2011) (35)
- Correlation between ribosylation of pertussis toxin substrates and inhibition of peptidoglycan‐, muramyl dipeptide‐ and lipopolysaccharide‐induced mitogenic stimulation in B lymphocytes (1989) (34)
- Bacterial Peptidoglycan as a Driver of Chronic Brain Inflammation. (2020) (31)
- The Bacterial Cell: Peptidoglycan (2002) (29)
- Studies on the mechanism of peptidoglycan- and lipopolysaccharide-induced polyclonal activation (1982) (27)
- Peptidoglycan Recognition Protein 3 and Nod2 Synergistically Protect Mice from Dextran Sodium Sulfate–Induced Colitis (2014) (27)
- Preferential induction of autoantibody secretion in polyclonal activation by peptidoglycan and lipopolysaccharide. II. In vivo studies. (1982) (27)
- Genetic Association of Peptidoglycan Recognition Protein Variants with Inflammatory Bowel Disease (2013) (27)
- Heparin, sulfated heparinoids, and lipoteichoic acids bind to the 70-kDa peptidoglycan/lipopolysaccharide receptor protein on lymphocytes. (1994) (27)
- Enhancement of mixed leukocyte reaction and cytotoxic antitumor responses by heparin. (1989) (25)
- Effects of Peptidoglycan on the Cellular Components of the Immune System (1986) (25)
- How innate immunity proteins kill bacteria and why they are not prone to resistance (2018) (24)
- Staphylococcal peptidoglycan: T-cell-dependent mitogen and relatively T-cell-independent polyclonal B-cell activator of human lymphocytes (1983) (23)
- Mitogenic responsiveness of mouse, rat and human lymphocytes to Staphylococcus aureus cell wall, teichoic acid, and peptidoglycan. (1980) (23)
- Enhancement of B-cell stimulation by muramyl dipeptide through a mechanism not involving interleukin 1 or increased Ca2+ mobilization or protein kinase C activation. (1988) (20)
- Relationships between adjuvant, immunosuppressive, and mitogenic activities of staphylococcal peptidoglycan (1979) (20)
- Deadly plague versus mild-mannered TLR4 (2006) (19)
- PEPTIDOGLYCAN RECOGNITION PROTEINS: 259 (2004) (19)
- A novel antimicrobial peptidoglycan recognition protein in the cornea. (2009) (19)
- Analysis of in vitro polyclonal B cell differentiation responses to bacterial peptidoglycan and pokeweed mitogen in rheumatoid arthritis. (1984) (18)
- Comparison of in vitro and in vivo mitogenic and polyclonal antibody and autoantibody responses to peptidoglycan, LPS, protein A, PWM, PHA and Con A in normal and autoimmune mice. (1985) (16)
- A Balancing Act: PGRPs Preserve and Protect. (2018) (15)
- Anti-immunoglobulin autoantibodies are not preferentially induced in polyclonal activation of human and mouse lymphocytes, and more anti-DNA and anti-erythrocyte autoantibodies are induced in polyclonal activation of mouse than human lymphocytes. (1984) (14)
- Peptidoglycan Recognition Proteins and Lysozyme (2016) (13)
- Opposing effects of xid and nu mutations on proliferative and polyclonal antibody and autoantibody responses to peptidoglycan, LPS, protein A and PWM. (1984) (13)
- Interactions of Bacterial Lipopolysaccharide and Peptidoglycan with Mammalian CD14 (2002) (11)
- Specific endotoxic lipopolysaccharide-binding receptors on murine splenocytes: III. Binding specificity and characterization. (1992) (11)
- Biological effects of staphylococcal cell wall and its components in mice (1976) (10)
- Binding sites for peptidoglycan on mouse lymphocytes. (1987) (10)
- Synergistic enhancement of T cell responses and interleukin-1 receptor expression by interleukin-1 and heparin or dextran sulfate. (1992) (10)
- Splenic macrophages: mediators of immunosuppressive activity of staphylococcal peptidoglycan. (1979) (9)
- The Pglyrp1-Regulated Microbiome Enhances Experimental Allergic Asthma (2019) (9)
- Peptidoglycan recognition protein-S (PGRP-S) is upregulated by NF-κB (2008) (9)
- Immunosuppressive effect of Staphylococcus aureus peptidoglycan on antibody response in mice. (1978) (8)
- Susceptibility of Staphylococcus aureus, Streptococcus pyogenes and Diplococcus pneumoniae to antibiotics. Comparison of patterns in Poland and Federal Republic of Germany. (1976) (8)
- Bacterial peptidoglycan binds to tubulin. (2000) (7)
- Formate dehydrogenase, ubiquinone, and cytochrome bd-I are required for peptidoglycan recognition protein-induced oxidative stress and killing in Escherichia coli (2020) (6)
- Effects of Staphylococcal Cell Wall Products on Immunity (1981) (6)
- Modulation of polyclonal activation by plasma fibronectin and fibronectin fragments. (1987) (6)
- Nod2 protects mice from inflammation and obesity-dependent liver cancer (2020) (6)
- Modulation of mitogenic responsiveness by staphylococcal peptidoglycan (1980) (6)
- Antibody responses to Staphylococcus aureus cell wall antigens (1985) (6)
- Pyrogenicity of staphylococcal peptidoglycan (1976) (5)
- Letters Natural autoantibodies might prevent autoimmune disease. (1987) (5)
- Stimulation of reticuloendothelial system and toxicity to macrophages of Staphylococcus aureus cell wall, peptidoglycan, and teichoic acid. (1977) (4)
- Gram-Negative Bacteria and Their Cell TLR 2-Mediated Responses to Gram-Positive Lipopolysaccharide and Enhances ( TLR 2 )-Mediated Responses to MD2 Enables Toll-Like Receptor 2 (2001) (4)
- Polyclonal B-cell activation in SLE: Frequencies of autoantibody secreting cells (1985) (4)
- Correction: Peptidoglycan Recognition Protein 1 Enhances Experimental Asthma by Promoting Th2 and Th17 and Limiting Regulatory T Cell and Plasmacytoid Dendritic Cell Responses (2013) (3)
- Peptidoglycan recognition protein-S (PGRP-S) is upregulated by NF-kappaB. (2008) (3)
- Delayed type hypersensitivity to Staphylococcus aureus peptidoglycan in guinea pigs. (1978) (3)
- Function of CD14 as a peptidoglycan receptor: differences and similarities with LPS (1999) (2)
- Natural autoantibodies might prevent autoimmune disease (1987) (2)
- Ontogenic development of proliferative and polyclonal antibody and autoantibody responses to staphylococcal peptidoglycan, protein A and cell walls in mice. (1985) (2)
- Respiratory chain components are required for peptidoglycan recognition protein-induced thiol depletion and killing in Bacillus subtilis and Escherichia coli (2021) (2)
- Susceptibility of Streptococcus faecalis to 32 antimicrobial agents. Comparison of patterns in Poland and Federal Republic of Germany. (1976) (1)
- The role of DNA synthesis in peptidoglycan-induced generation of immunoglobulin-secreting cells in mice and humans. (1985) (1)
- Bacteria causing podiatric infections, and processing of clinical specimens. (1985) (1)
- RECEPTORS AND SIGNALING PATHWAYS FOR GRAM‐POSITIVE CELL WALL COMPOUNDS.: 676 (1997) (0)
- Erratum: Cutting edge: Combined treatment of TNF-α and IFN-γ causes redistribution of junctional adhesion molecule in human endothelial cells (Journal of Immunology (July 1)) (1999) (0)
- Author Correction: Nod2 and Nod2-regulated microbiota protect BALB/c mice from diet-induced obesity and metabolic dysfunction (2018) (0)
- Antibacterial agents, bacterial resistance, and susceptibility tests. (1985) (0)
- Marrow-Derived Dendritic Cells Induces Cross-presentation by Bone A Subset of Toll-Like Receptor Ligands (2003) (0)
- Biological properties of the cell wall components of staphylococci and streptococci (Polish) (1976) (0)
- deficient mice - protein-S (PGRP-S) nonpathogenic gram-positive bacteria in peptidoglycan recognition Defect in neutrophil killing and increased susceptibility to infection with (2013) (0)
- Respiratory chain components are required for peptidoglycan recognition protein-induced thiol depletion and killing in Bacillus subtilis and Escherichia coli (2021) (0)
- Macroanalysis of Integration of the Basic Sciences in a Problem-Based Learning Curriculum (1997) (0)
- Preferential induction of autoantibody secretion in polyclonal activation in immunologically normal and "autoimmune" mice. Abstr. (1982) (0)
- Contents, Vol. 63, 1980 (1980) (0)
- Staphylococcal cell wall polysaccharides (1977) (0)
- Measurement of Cytokine and Chemokine Gene Expression Patterns Using cDNA Array (2001) (0)
- Susceptibility of clinically important gram-negative bacilli to 15 antibiotics. Comparison of patterns in Poland and Federal Republic of Germany. (1976) (0)
- How innate immunity proteins kill bacteria and why they are not prone to resistance (2017) (0)
- Regression of murine tumor growth by enzymatic dermoclysis coupled with immunostimulation. Abstr. (1978) (0)
- Bacterial Peptidoglycan-Inducedtnf- Transcription Is Mediated Through the Transcription Factors Egr-1, Elk-1, and NF- B (2001) (0)
- Induces Transcription of Interleukin-8 B Signal Transduction Pathway That κ NF- → IKK → NIK → TRAF → IRAK → MyD88 → TLR2 Micrococci and Peptidoglycan Activate (2014) (0)
- Mitogenic activity of staphylococcal cell wall poly saccharides (1979) (0)
- Book Review:Immunology of the Bacterial Cell Envelope. D. E. S. Stewart-Tull, M. Davies (1986) (0)
- Immunosuppressive effect of staphylococcal extracellular enzymes on antibody response in mice. Abstr. (1978) (0)
- Pathobiology 9-16-2011 Differential Effects of Peptidoglycan Recognition Proteins on Experimental Atopic and Contact Dermatitis Mediated by Treg and Th 17 Cells (2018) (0)
- Control of Lung Inflammation by Microbiome and Peptidoglycan Recognition Protein (2017) (0)
- CD14, An Innate Immune Receptor for Various Bacterial Cell Wall Components (2020) (0)
- Nod2 and Nod2-regulated microbiota protect BALB/c mice from diet-induced obesity and metabolic dysfunction (2017) (0)
- Immunotherapy of murine tumor with hyaluronidase and immunostimulants. Abstr. (1980) (0)
- Author Correction: Nod2 and Nod2-regulated microbiota protect BALB/c mice from diet-induced obesity and metabolic dysfunction (2018) (0)
- Peptidoglycan recognition protein 3-regulated microbiome maintains healthy levels of Treg cells and protects mice from colitis (INC1P.346) (2015) (0)
- Measurement of Cytokine and Chemokine mRNA Using Nonisotopic Multiprobe RNase Protection Assay (2001) (0)
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