Ronald Anthony Depinho

Ronald Anthony Depinho's AcademicInfluence.com Rankings

Philosophy

#2799

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#4671

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Logic

#789

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#1325

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Philosophy

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Ronald Anthony Depinho's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Malignant astrocytic glioma: genetics, biology, and paths to treatment. (2007) (2301)
Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA (1997) (2094)
Hepatocellular carcinoma pathogenesis: from genes to environment (2006) (1917)
The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin (2005) (1899)
International network of cancer genome projects (2010) (1839)
ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF (1991) (1788)
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. (2004) (1747)
Role of the INK4a Locus in Tumor Suppression and Cell Mortality (1996) (1675)
The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus (1999) (1645)
The Ink4a Tumor Suppressor Gene Product, p19Arf, Interacts with MDM2 and Neutralizes MDM2's Inhibition of p53 (1998) (1637)
FoxOs Are Critical Mediators of Hematopoietic Stem Cell Resistance to Physiologic Oxidative Stress (2007) (1564)
Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism (2012) (1527)
Glutamine supports pancreatic cancer growth through a Kras-regulated metabolic pathway (2013) (1473)
HDAC2 negatively regulates memory formation and synaptic plasticity (2009) (1429)
Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice (1999) (1359)
Essential role of mouse telomerase in highly proliferative organs (1998) (1297)
Malignant glioma: genetics and biology of a grave matter. (2001) (1253)
Pancreatic cancer biology and genetics (2002) (1168)
Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice (2000) (1101)
Genetics and biology of pancreatic ductal adenocarcinoma. (2006) (1094)
The LKB1 tumor suppressor negatively regulates mTOR signaling. (2004) (1084)
Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a (2006) (1083)
FoxOs Are Lineage-Restricted Redundant Tumor Suppressors and Regulate Endothelial Cell Homeostasis (2007) (1038)
Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment. (2017) (1019)
Insulin Signaling in Osteoblasts Integrates Bone Remodeling and Energy Metabolism (2010) (1001)
Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma. (2003) (994)
p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis (1999) (973)
Telomere dysfunction induces metabolic and mitochondrial compromise (2011) (960)
Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function (2014) (927)
Coactivation of Receptor Tyrosine Kinases Affects the Response of Tumor Cells to Targeted Therapies (2007) (922)
Essential role for oncogenic Ras in tumour maintenance (1999) (913)
Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression (1997) (895)
Suppression of Ovarian Follicle Activation in Mice by the Transcription Factor Foxo3a (2003) (888)
How stem cells age and why this makes us grow old (2007) (847)
Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis (2001) (840)
BRafV600E cooperates with Pten silencing to elicit metastatic melanoma (2009) (836)
Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects. (2004) (807)
Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith–Wiedemann syndrome (1997) (784)
Telomeres and telomerase in cancer. (2010) (765)
Telomerase reactivation reverses tissue degeneration in aged telomerase deficient mice (2010) (735)
Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis. (2002) (698)
P53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation (2008) (687)
Linking functional decline of telomeres, mitochondria and stem cells during ageing (2010) (668)
p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens (1994) (653)
Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer. (2006) (632)
PI3 Kinase Signals BCR-Dependent Mature B Cell Survival (2009) (622)
Cellular Senescence Minireview Mitotic Clock or Culture Shock? (2000) (595)
Somatic mutations of the histone H3K27 demethylase, UTX, in human cancer (2009) (595)
Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development (2000) (584)
Connecting chromosomes, crisis, and cancer. (2002) (583)
Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes (2010) (577)
Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome. (2004) (573)
The age of cancer (2000) (571)
The INK4A/ARF locus and its two gene products. (1999) (568)
Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse. (2006) (567)
A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice. (1998) (550)
Genetics and biology of pancreatic ductal adenocarcinoma (2006) (542)
Yap1 Activation Enables Bypass of Oncogenic Kras Addiction in Pancreatic Cancer (2014) (538)
Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver. (2007) (537)
Telomere dysfunction and evolution of intestinal carcinoma in mice and humans (2001) (535)
Emerging insights into the molecular and cellular basis of glioblastoma. (2012) (527)
Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor (2009) (507)
DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway. (2000) (503)
A Genetic Screen for Candidate Tumor Suppressors Identifies REST (2005) (494)
Cellular senescence: mitotic clock or culture shock? (2000) (493)
Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma. (2010) (493)
Telomeres, stem cells, senescence, and cancer. (2004) (485)
Regulation of autophagy and the ubiquitin–proteasome system by the FoxO transcriptional network during muscle atrophy (2015) (482)
An inhibitor of oxidative phosphorylation exploits cancer vulnerability (2018) (481)
Olig2-Regulated Lineage-Restricted Pathway Controls Replication Competence in Neural Stem Cells and Malignant Glioma (2007) (479)
Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization. (2005) (472)
SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression (2011) (471)
Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation (2002) (454)
Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes. (2006) (452)
Essential role of limiting telomeres in the pathogenesis of Werner syndrome (2004) (450)
Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells (2010) (434)
PKM2 Isoform-Specific Deletion Reveals a Differential Requirement for Pyruvate Kinase in Tumor Cells (2013) (430)
Cooperative effects of INK4a and ras in melanoma susceptibility in vivo. (1997) (425)
A functional T3 molecule associated with a novel heterodimer on the surface of immature human thymocytes (1986) (424)
FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis. (2009) (418)
Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformation (1999) (416)
High-resolution genomic profiles define distinct clinico-pathogenetic subgroups of multiple myeloma patients. (2006) (416)
High-resolution genomic profiles of human lung cancer. (2005) (412)
Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers (2007) (405)
LKB1 regulates quiescence and metabolic homeostasis of hematopoietic stem cells (2010) (399)
Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing (2003) (398)
An amino-terminal domain of Mxi1 mediates anti-myc oncogenic activity and interacts with a homolog of the Yeast Transcriptional Repressor SIN3 (1995) (395)
Short Dysfunctional Telomeres Impair Tumorigenesis in the INK4aΔ2/3 Cancer-Prone Mouse (1999) (394)
Analysis of C-MYC function in normal cells via conditional gene-targeted mutation. (2001) (393)
Inhibition of experimental liver cirrhosis in mice by telomerase gene delivery. (2000) (388)
The Differentiation and Stress Response Factor XBP-1 Drives Multiple Myeloma Pathogenesis (2007) (387)
Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation. (2008) (386)
SCFFBW 7 regulates cellular apoptosis by targeting MCL 1 for ubiquitylation and destruction (2011) (385)
Regulation of Genome Rearrangement Events during Lymphocyte Differentiation (1986) (384)
The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations. (2000) (364)
Effective Combinatorial Immunotherapy for Castration Resistant Prostate Cancer (2017) (358)
Targeting YAP-Dependent MDSC Infiltration Impairs Tumor Progression. (2016) (357)
DAP kinase activates a p19ARF/p53-mediated apoptotic checkpoint to suppress oncogenic transformation (2000) (350)
Model organisms: The mighty mouse: genetically engineered mouse models in cancer drug development (2006) (342)
Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway. (2008) (340)
Cooperation between the Cdk inhibitors p27(KIP1) and p57(KIP2) in the control of tissue growth and development. (1998) (331)
The INK4a/ARF tumor suppressor: one gene--two products--two pathways. (1998) (331)
Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferation (1998) (330)
A critical role for telomeres in suppressing and facilitating carcinogenesis. (2000) (330)
Genetics and biology of prostate cancer (2018) (329)
Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation. (2003) (324)
Stromal biology of pancreatic cancer (2007) (322)
N-myc can functionally replace c-myc in murine development, cellular growth, and differentiation. (2000) (320)
IL-7 Engages Multiple Mechanisms to Overcome Chronic Viral Infection and Limit Organ Pathology (2011) (313)
Constitutive telomerase expression promotes mammary carcinomas in aging mice (2002) (311)
Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation (2000) (308)
Context-dependent transformation of adult pancreatic cells by oncogenic K-Ras. (2009) (302)
Pten constrains centroacinar cell expansion and malignant transformation in the pancreas. (2005) (299)
Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion (2011) (298)
Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation (2008) (297)
SCFFbw7 Regulates Cellular Apoptosis By Targeting Mcl-1 for Ubiquitination and Destruction (2010) (296)
Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: assessment of an oral agent that stimulates erythropoietin production. (2006) (294)
Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein (1998) (294)
Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function. (2004) (293)
Passenger Deletions Generate Therapeutic Vulnerabilities in Cancer (2012) (292)
Axis of ageing: telomeres, p53 and mitochondria (2012) (291)
FoxO Transcription Factors Promote Cardiomyocyte Survival upon Induction of Oxidative Stress* (2010) (290)
High-resolution characterization of the pancreatic adenocarcinoma genome (2004) (278)
Foxo1 integrates insulin signaling with mitochondrial function in the liver (2009) (277)
Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells (2010) (273)
KRAS-IRF2 Axis Drives Immune Suppression and Immune Therapy Resistance in Colorectal Cancer. (2019) (268)
STAT3 is a negative regulator of granulopoiesis but is not required for G-CSF-dependent differentiation. (2002) (267)
FoxO1 is a positive regulator of bone formation by favoring protein synthesis and resistance to oxidative stress in osteoblasts. (2010) (266)
p53 Good Cop/Bad Cop (2002) (264)
A Foxo/Notch pathway controls myogenic differentiation and fiber type specification. (2007) (263)
Antitelomerase Therapy Provokes ALT and Mitochondrial Adaptive Mechanisms in Cancer (2012) (258)
Telomere dysfunction provokes regional amplification and deletion in cancer genomes. (2002) (253)
FoxO-mediated defense against oxidative stress in osteoblasts is indispensable for skeletal homeostasis in mice. (2010) (252)
AKT/FOXO Signaling Enforces Reversible Differentiation Blockade in Myeloid Leukemias (2011) (251)
A Mouse to Human Search for Plasma Proteome Changes Associated with Pancreatic Tumor Development (2008) (249)
Genome-wide retroviral insertional tagging of genes involved in cancer in Cdkn2a-deficient mice (2002) (239)
PLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and gliomas. (2010) (236)
myc family oncogenes in the development of normal and neoplastic cells. (1991) (235)
SUMO-1 Modification of Histone Deacetylase 1 (HDAC1) Modulates Its Biological Activities* (2002) (235)
Molecular diversity of astrocytes with implications for neurological disorders. (2004) (230)
The differential impact of p16INK4a or p19ARF deficiency on cell growth and tumorigenesis (2004) (223)
mSin3A corepressor regulates diverse transcriptional networks governing normal and neoplastic growth and survival. (2005) (220)
Secondary genomic rearrangement events in pre‐B cells: VHDJH replacement by a LINE‐1 sequence and directed class switching. (1986) (220)
Marked genomic differences characterize primary and secondary glioblastoma subtypes and identify two distinct molecular and clinical secondary glioblastoma entities. (2006) (216)
Class IA Phosphoinositide 3-Kinase Regulates Heart Size and Physiological Cardiac Hypertrophy (2005) (215)
Human N-myc is closely related in organization and nucleotide sequence to c-myc (1986) (214)
Transcription factor Foxo3 controls the magnitude of T cell immune responses by modulating the function of dendritic cells. (2009) (214)
Overlapping functions of Hdac1 and Hdac2 in cell cycle regulation and haematopoiesis (2010) (212)
Telomere Shortening Exposes Functions for the Mouse Werner and Bloom Syndrome Genes (2004) (211)
PCAF Modulates PTEN Activity*♦ (2006) (209)
Role of Mxi1 in ageing organ systems and the regulation of normal and neoplastic growth (1998) (203)
Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression. (2000) (203)
Targeted Nanoparticles for Imaging Incipient Pancreatic Ductal Adenocarcinoma (2007) (202)
Malignant melanoma: modern black plague and genetic black box. (1998) (202)
Adiponectin regulates bone mass via opposite central and peripheral mechanisms through FoxO1. (2013) (202)
Telomerase Reactivation following Telomere Dysfunction Yields Murine Prostate Tumors with Bone Metastases (2012) (202)
FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice. (2010) (202)
Epigenetic Activation of WNT5A Drives Glioblastoma Stem Cell Differentiation and Invasive Growth (2016) (202)
Genetic determinants of malignancy in a mouse model for oligodendroglioma. (2003) (195)
Telomere-based crisis: functional differences between telomerase activation and ALT in tumor progression. (2003) (195)
mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization (2008) (192)
Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway. (2005) (190)
Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer (2017) (187)
p19ARF targets certain E2F species for degradation (2001) (185)
PTEN is a major tumor suppressor in pancreatic ductal adenocarcinoma and regulates an NF-κB-cytokine network. (2011) (184)
HDAC 2 Negatively Regulates Memory Formation and Synaptic Plasticity (2012) (179)
p16(Ink4a) in melanocyte senescence and differentiation. (2002) (175)
Dual Inactivation of RB and p53 Pathways in RAS-Induced Melanomas (2001) (175)
Telomere dysfunction induces metabolic and mitochondrial compromise (2011) (168)
Impaired nonhomologous end-joining provokes soft tissue sarcomas harboring chromosomal translocations, amplifications, and deletions. (2001) (167)
Telomere dysfunction triggers developmentally regulated germ cell apoptosis. (2001) (167)
Pancreatic Lkb1 Deletion Leads to Acinar Polarity Defects and Cystic Neoplasms (2008) (165)
Differential impact of telomere dysfunction on initiation and progression of hepatocellular carcinoma. (2003) (163)
FoxO1 integrates direct and indirect effects of insulin on hepatic glucose production and glucose utilization (2015) (163)
Suppression of cell transformation by the cyclin-dependent kinase inhibitor p57KIP2 requires binding to proliferating cell nuclear antigen. (1998) (162)
SLP-65 regulates immunoglobulin light chain gene recombination through the PI(3)K-PKB-Foxo pathway (2008) (162)
Effect of TERT over-expression on the long-term transplantation capacity of hematopoietic stem cells (2003) (160)
Lung cancer signatures in plasma based on proteome profiling of mouse tumor models. (2011) (158)
p19(Arf) induces p53-dependent apoptosis during abelson virus-mediated pre-B cell transformation. (1998) (158)
Cancer: Crime and punishment (2005) (156)
Generation Of Functional Insulin-Producing Cells In The Gut By Foxo1 Ablation (2012) (155)
FoxOs integrate pleiotropic actions of insulin in vascular endothelium to protect mice from atherosclerosis. (2012) (155)
Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer (2008) (152)
ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence (2007) (152)
Symbiotic Macrophage-Glioma Cell Interactions Reveal Synthetic Lethality in PTEN-Null Glioma. (2019) (151)
The Autophagy-related Gene 14 (Atg14) Is Regulated by Forkhead Box O Transcription Factors and Circadian Rhythms and Plays a Critical Role in Hepatic Autophagy and Lipid Metabolism* (2012) (150)
LKB1 (XEEK1) regulates Wnt signalling in vertebrate development (2003) (146)
Characterization of melanocyte‐specific inducible Cre recombinase transgenic mice (2006) (146)
Voltage-Activated K+ Channels and Membrane Depolarization Regulate Accumulation of the Cyclin-Dependent Kinase Inhibitors p27Kip1 and p21CIP1 in Glial Progenitor Cells (1999) (145)
Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma. (2007) (144)
Mice transgenic for human CD4 and CCR5 are susceptible to HIV infection. (1997) (143)
Synthetic essentiality of chromatin remodelling factor CHD1 in PTEN-deficient cancer (2017) (143)
The FoxO3/type 2 deiodinase pathway is required for normal mouse myogenesis and muscle regeneration. (2010) (141)
Proinvasion metastasis drivers in early-stage melanoma are oncogenes. (2011) (140)
Gene-target recognition among members of the Myc superfamily and implications for oncogenesis (2000) (140)
Bcl2L12-mediated inhibition of effector caspase-3 and caspase-7 via distinct mechanisms in glioblastoma (2008) (140)
Animal Model for Maturity-onset Diabetes of the Young Generated by Disruption of the Mouse Glucokinase Gene (*) (1995) (139)
Codependent activators direct myoblast-specific MyoD transcription. (2008) (138)
Compression of pancreatic tumor blood vessels by hyaluronan is caused by solid stress and not interstitial fluid pressure. (2014) (138)
Rescue of a telomere length defect of Nijmegen breakage syndrome cells requires NBS and telomerase catalytic subunit (2001) (138)
FoxOs enforce a progression checkpoint to constrain mTORC1-activated renal tumorigenesis. (2010) (137)
Hepatic suppression of Foxo1 and Foxo3 causes hypoglycemia and hyperlipidemia in mice. (2012) (136)
Telomeres: history, health, and hallmarks of aging (2021) (133)
Hepatic SREBP-2 and cholesterol biosynthesis are regulated by FoxO3 and Sirt6[S] (2013) (132)
Inhibitor of differentiation 4 drives brain tumor-initiating cell genesis through cyclin E and notch signaling. (2008) (131)
Mice without telomerase: what can they teach us about human cancer? (2000) (130)
FoxO3 Transcription Factor and Sirt6 Deacetylase Regulate Low Density Lipoprotein (LDL)-cholesterol Homeostasis via Control of the Proprotein Convertase Subtilisin/Kexin Type 9 (Pcsk9) Gene Expression* (2013) (128)
Suppression of Myc, but not E1a, transformation activity by Max-associated proteins, Mad and Mxi1. (1994) (127)
Future cancer research priorities in the USA: a Lancet Oncology Commission. (2017) (125)
Cellular transformation by the MSP58 oncogene is inhibited by its physical interaction with the PTEN tumor suppressor. (2005) (124)
Identification of Mammalian Sds3 as an Integral Component of the Sin3/Histone Deacetylase Corepressor Complex (2002) (121)
Repression by the Mad(Mxi1)‐Sin3 complex (1998) (120)
Hepatic FoxOs Regulate Lipid Metabolism via Modulation of Expression of the Nicotinamide Phosphoribosyltransferase Gene* (2011) (120)
Mig-6 controls EGFR trafficking and suppresses gliomagenesis (2010) (119)
Myc family oncoproteins function through a common pathway to transform normal cells in culture: cross-interference by Max and trans-acting dominant mutants. (1992) (118)
Mouse reporter strain for noninvasive bioluminescent imaging of cells that have undergone Cre-mediated recombination. (2003) (117)
Role of Telomere Dysfunction in Cardiac Failure in Duchenne Muscular Dystrophy (2013) (117)
Pten and p53 converge on c-Myc to control differentiation, self-renewal, and transformation of normal and neoplastic stem cells in glioblastoma. (2008) (117)
Expression and activity of L-Myc in normal mouse development (1996) (116)
Specific requirement of the chromatin modifier mSin3B in cell cycle exit and cellular differentiation (2008) (116)
Telomere dysfunction alters the chemotherapeutic profile of transformed cells (2001) (116)
Cooperative interactions of p53 mutation, telomere dysfunction, and chronic liver damage in hepatocellular carcinoma progression. (2006) (116)
Neurotransmitter receptor activation triggers p27(Kip1 )and p21(CIP1) accumulation and G1 cell cycle arrest in oligodendrocyte progenitors. (1999) (115)
FOXO1 in the ventromedial hypothalamus regulates energy balance. (2012) (115)
FoxO4 inhibits NF-kappaB and protects mice against colonic injury and inflammation. (2009) (114)
Oncogenic Kras drives invasion and maintains metastases in colorectal cancer. (2017) (114)
LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis (2008) (114)
The Obesity Susceptibility Gene Carboxypeptidase E Links FoxO1 Signaling in Hypothalamic Pro–opiomelanocortin Neurons with Regulation of Food Intake (2009) (114)
A genome-wide screen reveals functional gene clusters in the cancer genome and identifies EphA2 as a mitogen in glioblastoma. (2006) (113)
Decreased Cyclin-Dependent Kinase 5 (cdk5) Activity Is Accompanied by Redistribution of cdk5 and Cytoskeletal Proteins and Increased Cytoskeletal Protein Phosphorylation in p35 Null Mice (2003) (111)
Forkhead Box, Class O Transcription Factors in Brain: Regulation and Behavioral Manifestation (2009) (111)
Structure and expression of the murine N-myc gene. (1986) (110)
The human myc gene family. (1986) (110)
FoxO4 Regulates Tumor Necrosis Factor Alpha-Directed Smooth Muscle Cell Migration by Activating Matrix Metalloproteinase 9 Gene Transcription (2007) (110)
Telomeres and Mitochondria in the Aging Heart (2012) (110)
Neuroplastic changes occur early in the development of pancreatic ductal adenocarcinoma. (2014) (108)
Effects of the MYC oncogene antagonist, MAD, on proliferation, cell cycling and the malignant phenotype of human brain tumour cells (1995) (108)
Drosophila Myc is oncogenic in mammalian cells and plays a role in the diminutive phenotype. (1997) (107)
STAR RNA-binding protein Quaking suppresses cancer via stabilization of specific miRNA. (2012) (106)
Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase (2014) (106)
Erratum: Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment (Cancer Cell (2017) 32(1) (42–56.e6)(S1535610817302532)(10.1016/j.ccell.2017.06.003)) (2018) (105)
The human myc gene family: structure and activity of L-myc and an L-myc pseudogene. (1987) (102)
Syndecan1 is a critical mediator of macropinocytosis in pancreatic cancer (2019) (101)
ILF2 Is a Regulator of RNA Splicing and DNA Damage Response in 1q21-Amplified Multiple Myeloma. (2017) (101)
Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240 (2012) (101)
Contrasting roles for Myc and Mad proteins in cellular growth and differentiation. (1995) (99)
In Vivo Functional Platform Targeting Patient-Derived Xenografts Identifies WDR5-Myc Association as a Critical Determinant of Pancreatic Cancer. (2016) (98)
mSin3-associated protein, mSds3, is essential for pericentric heterochromatin formation and chromosome segregation in mammalian cells. (2003) (98)
Essential role for Max in early embryonic growth and development. (2000) (98)
mTORC1 signaling governs hematopoietic stem cell quiescence (2009) (97)
Cancer chromosomes in crisis (2004) (97)
Coxsackievirus and adenovirus receptor is essential for cardiomyocyte development (2005) (96)
Synergism between INK4a/ARF inactivation and aberrant HGF/SF signaling in rhabdomyosarcomagenesis (2002) (95)
Chronic bile duct injury associated with fibrotic matrix microenvironment provokes cholangiocarcinoma in p53-deficient mice. (2006) (95)
Ink4a/arf deficiency promotes ultraviolet radiation-induced melanomagenesis. (2002) (94)
Alu elements mediate MYB gene tandem duplication in human T-ALL (2007) (94)
Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer (2017) (92)
Collateral Lethality: A new therapeutic strategy in oncology. (2015) (92)
mTORC1 Promotes Denervation-Induced Muscle Atrophy Through a Mechanism Involving the Activation of FoxO and E3 Ubiquitin Ligases (2014) (92)
The Hermansky–Pudlak Syndrome: REPORT OF THREE CASES AND REVIEW OF PATHOPHYSIOLOGY AND MANAGEMENT CONSIDERATIONS (1985) (92)
Three-dimensional visualization of microvessel architecture of whole-mount tissue by confocal microscopy. (2006) (91)
IgH enhancer‐mediated deregulation of N‐myc gene expression in transgenic mice: generation of lymphoid neoplasias that lack c‐myc expression. (1989) (90)
Deletion of Hepatic FoxO1/3/4 Genes in Mice Significantly Impacts on Glucose Metabolism through Downregulation of Gluconeogenesis and Upregulation of Glycolysis (2013) (87)
Cancer research: past, present and future (2011) (86)
Foxo1 Links Hyperglycemia to LDL Oxidation and Endothelial Nitric Oxide Synthase Dysfunction in Vascular Endothelial Cells (2009) (86)
Oncolytic herpes virus with defective ICP6 specifically replicates in quiescent cells with homozygous genetic mutations in p16 (2008) (85)
Telomere dysfunction drives aberrant hematopoietic differentiation and myelodysplastic syndrome. (2015) (85)
Zebra fish myc family and max genes: differential expression and oncogenic activity throughout vertebrate evolution (1993) (84)
Oncogenic Kras driven metabolic reprogramming in pancreas cancer cells utilizes cytokines from the tumor microenvironment. (2020) (84)
Telomeres and the DNA damage response: why the fox is guarding the henhouse. (2004) (83)
Forkhead Transcription Factors (FoxOs) Promote Apoptosis of Insulin-Resistant Macrophages During Cholesterol-Induced Endoplasmic Reticulum Stress (2008) (82)
Use of the human EF-1alpha promoter for expression can significantly increase success in establishing stable cell lines with consistent expression: a study using the tetracycline-inducible system in human cancer cells. (1999) (82)
Efficiency Alleles of the Pctr1 Modifier Locus for Plasmacytoma Susceptibility (2001) (82)
Synergism between INK4a/ARF inactivation and aberrant HGF/SF signaling in rhabdomyosarcomagenesis (2003) (81)
Genetic analysis of Pten and Ink4a/Arf interactions in the suppression of tumorigenesis in mice. (2002) (81)
Genetic analysis of Pten and Ink4a/Arf interactions in the suppression of tumorigenesis in mice (2002) (80)
FoxO Function Is Essential for Maintenance of Autophagic Flux and Neuronal Morphogenesis in Adult Neurogenesis (2018) (80)
Brain metastasis: opportunities in basic and translational research. (2009) (79)
Glioma oncoprotein Bcl2L12 inhibits the p53 tumor suppressor. (2010) (78)
Obligate Roles for p16Ink4a and p19Arf-p53 in the Suppression of Murine Pancreatic Neoplasia (2002) (78)
Identification of novel alternative splice isoforms of circulating proteins in a mouse model of human pancreatic cancer. (2009) (78)
Chimeric mouse tumor models reveal differences in pathway activation between ERBB family– and KRAS-dependent lung adenocarcinomas (2010) (77)
Transcriptional repression: The cancer-chromatin connection (1998) (76)
DNA-Dependent Protein Kinase Catalytic Subunit Is Not Required for Dysfunctional Telomere Fusion and Checkpoint Response in the Telomerase-Deficient Mouse (2006) (76)
Common and distinct genomic events in sporadic colorectal cancer and diverse cancer types. (2007) (74)
Cyclin D- and E-Dependent Kinases and the p57KIP2 Inhibitor: Cooperative Interactions In Vivo (1999) (73)
Use of transgenic mice to study myc family gene function in normal mammalian development and in cancer. (1994) (72)
p16(INK4a) and p53 deficiency cooperate in tumorigenesis. (2002) (72)
SF2312 is a natural phosphonate inhibitor of Enolase (2016) (72)
Human CPR (cell cycle progression restoration) genes impart a Far- phenotype on yeast cells. (1997) (71)
Targeting EGFR Induced Oxidative Stress by PARP1 Inhibition in Glioblastoma Therapy (2010) (71)
Programmable base editing of mutated TERT promoter inhibits brain tumour growth (2020) (71)
Azathioprine and the liver. Evidence favoring idiosyncratic, mixed cholestatic-hepatocellular injury in humans. (1984) (70)
Sin3a Is Required by Sertoli Cells to Establish a Niche for Undifferentiated Spermatogonia, Germ Cell Tumors, and Spermatid Elongation (2010) (70)
Cancer Stemness Meets Immunity: From Mechanism to Therapy (2021) (69)
Neutralization of terminal differentiation in gliomagenesis (2013) (68)
Modeling chromosomal instability and epithelial carcinogenesis in the telomerase-deficient mouse. (2001) (67)
Circadian regulator CLOCK recruits immune suppressive microglia into the GBM tumor microenvironment. (2020) (67)
Metabolic Codependencies in the Tumor Microenvironment. (2021) (66)
FOXO1 orchestrates the bone-suppressing function of gut-derived serotonin. (2012) (65)
Prolonged activation of the mitogen-activated protein kinase pathway promotes DNA synthesis in primary hepatocytes from p21Cip-1/WAF1-null mice, but not in hepatocytes from p16INK4a-null mice. (1998) (65)
Towards patient-based cancer therapeutics (2010) (65)
Crosstalk between NOTCH and AKT signaling during murine megakaryocyte lineage specification. (2011) (65)
Telomerase extracurricular activities (2002) (64)
FoxO3 an important player in fibrogenesis and therapeutic target for idiopathic pulmonary fibrosis (2017) (64)
Structure and expression of the murine L‐myc gene. (1987) (62)
Molecular Chaperone gp96 Is a Novel Therapeutic Target of Multiple Myeloma (2013) (62)
Mutant Kras- and p16-regulated NOX4 activation overcomes metabolic checkpoints in development of pancreatic ductal adenocarcinoma (2017) (61)
Increased polyploidy in aortic vascular smooth muscle cells during aging is marked by cellular senescence (2007) (59)
Prognostic Determinants in Prostate Cancer (2011) (59)
Genetic events that limit the efficacy of MEK and RTK inhibitor therapies in a mouse model of KRAS-driven pancreatic cancer. (2015) (58)
Sustained mammary gland‐directed, ponasterone A‐inducible expression in transgenic mice (2000) (58)
Regulation of Pancreatic Juxtaductal Endocrine Cell Formation by FoxO1 (2009) (58)
Tumor microenvironment remodeling enables bypass of oncogenic KRAS dependency in pancreatic cancer. (2020) (58)
What drives intense apoptosis resistance and propensity for necrosis in glioblastoma? A role for Bcl2L12 as a multifunctional cell death regulator (2008) (57)
Genetic and biological hallmarks of colorectal cancer (2021) (57)
Unlimited Mileage from Telomerase? (1999) (57)
The PTEN and INK4A/ARF tumor suppressors maintain myelolymphoid homeostasis and cooperate to constrain histiocytic sarcoma development in humans. (2006) (57)
Ink4a/Arf tumor suppressor does not modulate the degenerative conditions or tumor spectrum of the telomerase-deficient mouse (2007) (55)
Up-regulation of c-Jun inhibits proliferation and induces apoptosis via caspase-triggered c-Abl cleavage in human multiple myeloma. (2007) (55)
PRKCI promotes immune suppression in ovarian cancer (2017) (55)
Structural and functional analysis of the mouse mdr1b gene promoter. (1991) (53)
IRS2 signaling in LepR-b neurons suppresses FoxO1 to control energy balance independently of leptin action. (2012) (53)
Dissecting genetic requirements of human breast tumorigenesis in a tissue transgenic model of human breast cancer in mice (2009) (52)
Impaired processing of DNA photoproducts and ultraviolet hypermutability with loss of p16INK4a or p19ARF. (2004) (51)
Beyond effector caspase inhibition (2011) (51)
P 53 and Pten control neural and glioma stem / progenitor cell renewal and differentiation (2014) (51)
STAT3 Inhibition Combined with CpG Immunostimulation Activates Antitumor Immunity to Eradicate Genetically Distinct Castration-Resistant Prostate Cancers (2018) (50)
Foxk1 promotes cell proliferation and represses myogenic differentiation by regulating Foxo4 and Mef2 (2012) (50)
Myc family of cellular oncogenes (1987) (50)
Modulation of epithelial neoplasia and lymphoid hyperplasia in PTEN+/- mice by the p85 regulatory subunits of phosphoinositide 3-kinase. (2005) (50)
Telomere dysfunction promotes genome instability and metastatic potential in a K-ras p53 mouse model of lung cancer. (2008) (49)
Murine dendritic cell rapamycin-resistant and rictor-independent mTOR controls IL-10, B7-H1, and regulatory T-cell induction. (2013) (49)
Direct transcriptional activation of promyelocytic leukemia protein by IFN regulatory factor 3 induces the p53-dependent growth inhibition of cancer cells. (2007) (47)
Lens complementation system for the genetic analysis of growth, differentiation, and apoptosis in vivo. (1996) (46)
Animal models of melanoma: recent advances and future prospects. (2000) (45)
Differential regulation of the N-myc gene in transfected cells and transgenic mice (1990) (45)
Loss of FOXO1 Cooperates with TMPRSS2-ERG Overexpression to Promote Prostate Tumorigenesis and Cell Invasion. (2017) (44)
Block of T cell development in P53-deficient mice accelerates development of lymphomas with characteristic RAG-dependent cytogenetic alterations. (2006) (44)
Effective combinatorial immunotherapy for penile squamous cell carcinoma (2020) (44)
Fungal mycobiome drives IL-33 secretion and type 2 immunity in pancreatic cancer. (2022) (44)
Mouse models for the study of telomerase. (1997) (44)
Survival factor NFIL3 restricts FOXO-induced gene expression in cancer. (2013) (43)
USP21 deubiquitinase promotes pancreas cancer cell stemness via Wnt pathway activation (2019) (43)
The genetics of pancreatic adenocarcinoma: a roadmap for a mouse model. (2001) (43)
Mouse Sin3A interacts with and can functionally substitute for the amino-terminal repression of the Myc antagonist Mxi1. (1996) (42)
Cancer biology: Gone but not forgotten (2007) (42)
Cdk5/p35 Phosphorylates mSds3 and Regulates mSds3-mediated Repression of Transcription* (2004) (42)
Endothelial FoxO1 is an intrinsic regulator of thrombospondin 1 expression that restrains angiogenesis in ischemic muscle (2013) (41)
Tetracycline-inducible system for photoreceptor-specific gene expression. (2000) (41)
Chromatin Regulator, CHD1, Remodels the Immunosuppressive Tumor Microenvironment in PTEN-Deficient Prostate Cancer. (2020) (41)
Erratum: Telomere dysfunction induces metabolic and mitochondrial compromise (Nature (2011) 470 (359-365)) (2011) (41)
Myc and Max: a putative transcriptional complex in search of a cellular target. (1992) (40)
Impact papers on aging in 2009 (2010) (40)
PAF-mediated MAPK signaling hyperactivation via LAMTOR3 induces pancreatic tumorigenesis. (2013) (39)
Telomere-dependent senescence (1999) (39)
Molecular basis of heavy-chain class switching and switch region deletion in an Abelson virus-transformed cell line (1984) (38)
Targeting cathepsin E in pancreatic cancer by a small molecule allows in vivo detection. (2013) (38)
Tissue plasminogen activator and NMDA receptor cleavage (2003) (37)
Inhibition of colon tumor progression and angiogenesis by the Ink4a/Arf locus. (2003) (37)
Unique challenges for glioblastoma immunotherapy - Discussions across neuro-oncology and non-neuro-oncology experts in cancer immunology. (2020) (36)
The genetic and environmental basis of hepatocellular carcinoma. (2006) (36)
SUMOylation of ROR-γt inhibits IL-17 expression and inflammation via HDAC2 (2018) (36)
The age of cancer: telomeres, checkpoints, and longevity. (2003) (36)
Induction of melanoma in murine macrophage inflammatory protein 2 transgenic mice heterozygous for inhibitor of kinase/alternate reading frame. (2001) (35)
PAF promotes stemness and radioresistance of glioma stem cells (2017) (35)
Flipping the oncogene switch: illumination of tumor maintenance and regression. (2000) (35)
IgH enhancer deregulated expression of L‐myc: abnormal T lymphocyte development and T cell lymphomagenesis. (1990) (35)
Distinct roles for Foxo1 at multiple stages of B cell differentiation (2008) (34)
Functional Genomics Reveals Synthetic Lethality between Phosphogluconate Dehydrogenase and Oxidative Phosphorylation. (2019) (34)
Identification and characterization of genes. (2002) (32)
Keeping telomerase in its place (2002) (31)
Evolutionary relationships and functional conservation among vertebrate Max-associated proteins: the zebra fish homolog of Mxi1. (1994) (31)
Telomere dysfunction activates YAP1 to drive tissue inflammation (2020) (30)
Comparative analysis of the expression and oncogenic activities of Xenopus c-, N-, and L-myc homologs (1993) (29)
An Enolase Inhibitor for the Targeted Treatment of ENO1-Deleted Cancers (2020) (29)
Erratum: Effects of the MYC oncogene antagonist, MAD, on proliferation, cell cycling and the malignant phenotype of human brain tumour cells (Nature Medicine (1995) 1 (638-643)) (1995) (29)
Take care of your chromosomes lest cancer take care of you. (2003) (29)
FoxO1 in dopaminergic neurons regulates energy homeostasis and targets tyrosine hydroxylase (2016) (29)
The role of Ink4a/Arf in ErbB2 mammary gland tumorigenesis. (2003) (28)
Overlapping functions of Hdac 1 and Hdac 2 in cell cycle regulation and hematopoiesis (2010) (28)
Distinct requirements for Sin3a in perinatal male gonocytes and differentiating spermatogonia. (2013) (28)
The WNT receptor ROR2 drives the interaction of multiple myeloma cells with the microenvironment through AKT activation (2019) (28)
A BAC transgenic reporter recapitulates in vivo regulation of human telomerase reverse transcriptase in development and tumorigenesis (2011) (27)
Opposing roles of TGFβ and BMP signaling in prostate cancer development (2017) (26)
Hepatocyte transplantation improves survival in mice with liver toxicity induced by hepatic overexpression of Mad1 transcription factor. (2000) (26)
Lipid-loaded tumor-associated macrophages sustain tumor growth and invasiveness in prostate cancer (2021) (26)
Optochemogenetics (OCG) allows more precise control of genetic engineering in mice with CreER regulators. (2012) (25)
Tailor-made monoclonal antibodies. (1986) (24)
PTEN: A Novel Anti-oncogenic Function Independent of Phosphatase Activity (2005) (24)
Transcription factors Foxo 3 a and Foxo 1 couple the E 3 ligase Cbl-b to the induction of Foxp 3 expression in induced regulatory T cells (2010) (24)
Complex transcriptional regulation of myc family gene expression in the developing mouse brain and liver (1991) (23)
A mouse plasma peptide atlas as a resource for disease proteomics (2008) (23)
A strong candidate gene for the Papg1 locus on mouse chromosome 4 affecting lung tumor progression (2002) (23)
Mouse Reporter Strain for Noninvasive Bioluminescent Imaging of Cells that have Undergone Cre-Mediated Recombination (2003) (23)
The interplay between nonhomologous end-joining and cell cycle checkpoint factors in development, genomic stability, and tumorigenesis. (2000) (22)
MAPRE1 as a Plasma Biomarker for Early-Stage Colorectal Cancer and Adenomas (2015) (22)
Transcription Factor FoxO1 Is Essential for Enamel Biomineralization (2012) (22)
Conquering the complexity of p53 (2004) (21)
Common and contrasting genomic profiles among the major human lung cancer subtypes. (2005) (20)
Differential expression of myc-family genes during development: normal and deregulated N-myc expression in transgenic mice. (1988) (19)
Activation of FoxO3a/Bim axis in patients with Primary Biliary Cirrhosis (2013) (19)
Synthetic essentiality: Targeting tumor suppressor deficiencies in cancer (2017) (19)
Single-cell RNA sequencing in pancreatic cancer (2021) (19)
Forkhead box O transcription factors in chondrocytes regulate endochondral bone formation (2016) (19)
The Ink4a Tumor Suppressor Gene Product, p19 Arf , Interacts with MDM2 and Neutralizes (1998) (19)
Coding of smooth eye movements in three-dimensional space by frontal cortex (19)
Loss of transcriptional attenuation in N-myc is associated with progression towards a more malignant phenotype. (1995) (19)
Absence of telomerase and shortened telomeres have minimal effects on skin and pancreatic carcinogenesis elicited by viral oncogenes. (2004) (18)
ZNF365 promotes stability of fragile sites and telomeres. (2013) (17)
Eradication of ENO1-deleted Glioblastoma through Collateral Lethality (2018) (17)
Haploinsufficiency of the mSds3 chromatin regulator promotes chromosomal instability and cancer only upon complete neutralization of p53 (2006) (16)
Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc (1999) (16)
Tumorigenic and developmental effects of combined germ-line mutations in Rb and p53. (1994) (15)
Telomere dysfunction instigates inflammation in inflammatory bowel disease (2021) (15)
Walking the telomere plank into cancer. (2003) (15)
Role of first exon/intron sequences in the regulation of myc family oncogenic potency. (1993) (15)
ATR-mediated CD47 and PD-L1 up-regulation restricts radiotherapy-induced immune priming and abscopal responses in colorectal cancer (2021) (14)
A Genome-Wide Screen Reveals Functional Gene Clusters in the Cancer Genome and Identifies EphA 2 as a Mitogen in Glioblastoma (2006) (13)
Overexpression of Mad transcription factor inhibits proliferation of cultured human hepatocellular carcinoma cells along with tumor formation in immunodeficient animals (2000) (13)
Modeling prostate cancer in the mouse. (2001) (12)
Diminished lifespan and acute stress-induced death in DNA-PKcs-deficient mice with limiting telomeres (2007) (12)
Foxo3 controls the magnitude of T cell immune responses by modulating dendritic cell function (2009) (12)
The glucocorticoid hormone signal transduction pathway in mice homozygous for chromosomal deletions causing failure of cell type-specific inducible gene expression. (1991) (12)
Context-Dependent Transformation of Adult Pancreatic Cells by Oncogenic KRas Citation (2009) (11)
Functional interactions among members of the Myc superfamily and potential relevance to cutaneous growth and development. (1996) (11)
USP21 deubiquitinase elevates macropinocytosis to enable oncogenic KRAS bypass in pancreatic cancer (2021) (11)
An In Vivo Screen Identifies PYGO2 as a Driver for Metastatic Prostate Cancer. (2018) (11)
p16Ink4a Interferes with Abelson Virus Transformation by Enhancing Apoptosis (2004) (11)
Impact papers on aging in 2009 - eScholarship (2010) (11)
Seminars in Cancer Biology: Introduction (2001) (10)
Erratum: Yap1 Activation Enables Bypass of Oncogenic Kras Addiction in Pancreatic Cancer (Yap1 Activation Enables Bypass of Oncogenic Kras Addiction in Pancreatic Cancer (2014) 158(1) (185–197), (S0092867414007247), (10.1016/j.cell.2014.06.003)) (2019) (10)
FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice (Journal of Clinical Investigation (2010) 120, 1 (357-368) (DOI: 10.1172/JCI39901)) (2010) (10)
Erratum: FoxO1 integrates direct and indirect effects of insulin on hepatic glucose production and glucose utilization (2015) (10)
FoxO1 is required for physiological cardiac hypertrophy induced by exercise but not by constitutively active PI3K. (2021) (10)
In vitro enzymatic activity assay for ENOLASE in mammalian cells in culture (2012) (9)
Cancer: Telomerase meets its mismatch (2001) (8)
A bumper crop of cancer genes (1999) (8)
Corrigendum: Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway (2013) (8)
Stereotactic Orthotopic Xenograft Injections into the Mouse Brain (2012) (8)
Cancer signaling: when phosphorylation meets methylation (2014) (8)
Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma (2021) (8)
Telomerase reverse transcriptase preserves neuron survival and cognition in Alzheimer’s disease models (2021) (7)
Studies on the Somatic Instability of Immunoglobulin Genes in vivo and in Cultured Cells (1987) (7)
How Disruption of Cell Cycle Regulators Might Predispose to Sun-Induced Skin Cancer (2005) (7)
Epigenetic Activation of WNT 5 A Drives Glioblastoma Stem Cell Differentiation and Invasive Growth Graphical Abstract Highlights (2018) (7)
Drivers of Transcriptional Variance in Human Intestinal Epithelial Organoids (2021) (6)
Erratum: Effective combinatorial immunotherapy for castration-resistant prostate cancer (2017) (6)
When the world turned cold (2007) (6)
Drivers of Transcriptional Variance in Human Intestinal Epithelial Organoids. (2021) (6)
A tumor vessel-targeting fusion protein elicits a chemotherapeutic bystander effect in pancreatic ductal adenocarcinoma. (2017) (5)
Comprehensive Genome-Wide Profile of Regional Gains and Losses in Multiple Myeloma Using Array-CGH: The 1q21 Amplification and Potential Role of the BCL-9 Gene in Multiple Myeloma Pathogenesis. (2004) (5)
Synthetic Essentiality of Tryptophan 2,3-dioxygenase 2 in APC-Mutated Colorectal Cancer. (2022) (5)
Cancer prevention in developing countries: a vision for preserving health in Mexico. (2016) (5)
Myc family genes: a dispersed multi-gene family. (1986) (5)
A biochemical and biological analysis of Myc superfamily interactions. (1997) (5)
Erratum: Synergism between INK4a/ARF inactivation and aberrant HGF/SF signaling in rhabdomyosarcomagenesis (Nature Medicine (2002) 8 (1276-1280)) (2003) (5)
Introduction. The laboratory mouse in cancer research. (2001) (5)
Cancer Drug Discovery Faces the FACT (2011) (5)
Erratum: Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma (Ecography (2007) 21 (98-111)) (2007) (5)
Targeted Overexpression of the Transcription Factor XBP-1 in B Cells Promotes Plasma Cell and Lymphoplasmacytic Neoplasms in Transgenic Mice. (2005) (4)
Targeting T cell checkpoints 41BB and LAG3 and myeloid cell CXCR1/CXCR2 results in antitumor immunity and durable response in pancreatic cancer (2022) (4)
Advances in Brief p 16 INK 4 a and p 53 Deficiency Cooperate in Tumorigenesis 1 (2002) (4)
The PTEN and INK4A/ARF tumor suppressors maintain myelolymphoid homeostasis and cooperate to constrain histiocytic sarcoma development in humans (DOI: 10.1016/j.ccr.2006.03.028) (2006) (4)
Identification of Blood-Based Biomarkers for the Prediction of the Response to Neoadjuvant Chemoradiation in Rectal Cancer (2021) (4)
governing normal and neoplastic growth and survival mSin 3 A corepressor regulates diverse transcriptional networks data (2005) (4)
5 Modeling Cancer and Aging in the Telomerase-deficient Mouse (2006) (4)
Cancer moonshot countdown (2016) (4)
Involvement of the Ink4a gene (p16 and p19arf) in murine tumorigenesis. (1999) (4)
Instability of immunoglobulin genes in S107 cell line (1991) (4)
Ink 4 a Interferes with Abelson Virus Transformation by Enhancing Apoptosis (2004) (4)
Cancer Therapy : Preclinical Molecular Chaperone gp 96 Is a Novel Therapeutic Target of Multiple Myeloma (2013) (4)
3D imaging analysis on an organoid-based platform guides personalized treatment in pancreatic ductal adenocarcinoma (2022) (3)
The Role of Ink 4 a / Arf in ErbB 2 Mammary Gland Tumorigenesis 1 (2003) (3)
glioblastoma Bcl 2 L 12 inhibits post-mitochondrial apoptosis signaling in Material Supplemental (2006) (3)
Corrigendum: Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome. (2019) (3)
FoxO1 regulates leptin-induced mood behavior by targeting tyrosine hydroxylase. (2019) (3)
AKT/FOXO Signaling Enforces Reversible Differentiation Blockade in Myeloid Leukemias (2011) (3)
HDAC2 in Primary Sensory Neurons Constitutively Restrains Chronic Pain by Repressing α2δ-1 Expression and Associated NMDA Receptor Activity (2022) (3)
Syndecan 1 is a critical mediator of macropinocytosis in pancreatic cancer (2019) (3)
FoxO Are Critical Mediators of Hematopoietic Stem Cell Resistance to Physiologic Oxidative Stress. (2006) (2)
Straight talk with... Ronald DePinho. Interview by Rebecca Hersher. (2012) (2)
The role of monoclonal antibodies and the recombinant DNA technology in studying autoantibody production. (1986) (2)
Quantification of telomere length by FISH and laser scanning cytometry (2008) (2)
Telomere Dysfunction as an Initiator of Inflammation: Clues to an Age-Old Mystery (2021) (2)
cooperativity of Ink 4 a / ARF and Trp 53 loss of function mice : Pax 3 : FkhrAlveolar rhabdomyosarcomas in conditional data (2004) (2)
A Regulatory Network Between Notch and AKT Signaling Pathways Differentially Controls Megakaryocyte Development From Hematopoietic Stem or Committed Progenitor Cells. (2009) (2)
Foxo1 links hyperglycemia to LDL oxidation and eNOS dysfunction in vascular endothelial cells (2009) (2)
Ink 4 a / Arf Deficiency Promotes Ultraviolet Radiation-induced Melanomagenesis 1 (2002) (2)
Introductory comments (1999) (2)
Telomere dysfunction suppresses multiple endocrine neoplasia in mice (2014) (2)
Mouse model for regulation of telomerase (1997) (1)
Leukemogenic Transformation of Hematopoietic Cells by Constitutive Activation of Canonical Wnt Signaling in Osteoblast Precursors (2012) (1)
Repression by the Mad‐Sin3 complex (1998) (1)
AR-negative prostate cancer is vulnerable to loss of JMJD1C demethylase (2021) (1)
genesis through cyclin E and notch signaling Inhibitor of differentiation 4 drives brain tumor-initiating cell (2008) (1)
ILF2 Is a Regulator of RNA Splicing and DNA Damage Response in 1q21-Amplified Multiple Myeloma (2014) (1)
FoxO3 transcription factor and Sirt6 deacetylase regulate LDL-cholesterol homeostasis via control of the proprotein convertase subtilisin/kexin type 9 (Pcsk9) gene expression (2013) (1)
Erratum: Molecular diversity of astrocytes with implications for neurological disorders (Proceedings of the National Academy of Sciencs of the United States of America (June 1, 2004) 101, 22 (8384-8389)) (2004) (1)
Corrigendum: Passenger deletions generate therapeutic vulnerabilities in cancer (2015) (1)
Regulation of the Assembly and Expression of Immunoglobulin Genes: Variable Region Assembly and Heavy Chain Class Switching (1986) (1)
Erratum: Telomere-based crisis: Functional differences between telomerase activation and alt in tumor progression (Genes and Development (2003) 17 (88-100)) (2003) (1)
Cardiac-Specific Deletion of Foxo1 Causes Heart Dysfunction in Mice (2010) (1)
Endothelial FoxO1 is an intrinsic regulator of thrombospondin 1 expression that restrains angiogenesis in ischemic muscle (2013) (1)
Correction: Targeting EGFR Induced Oxidative Stress by PARP1 Inhibition in Glioblastoma Therapy (2011) (1)
Abstract A39: Pomhex, a cell-permeable high potency enolase inhibitor with utility for collateral lethality treatment of cancer (2017) (1)
Abstract A51: Oncogenic Kras is required for pancreatic tumor maintenance through the regulation of anabolic glucose metabolism. (2012) (0)
Abstract PR13: Pancreatic tumor stem cells resistant to inhibition of oncogenic signaling are dependent on mitochondrial function (2015) (0)
[Transcultural psychiatry in Brazil: Rubim de Pinho and "psychoses" of the national culture]. (2003) (0)
Telomerase extracurricular a( (2016) (0)
Knowledge about the HPV vaccine among employees at a tertiary cancer center: Room for improvement (2016) (0)
Molecular Basis ofHeavy-Chain Class Switching andSwitch Region Deletion inan Abelson Virus-Transformed CellLine (1984) (0)
treatmentastrocytic glioma: genetics, biology, and paths to (2008) (0)
Inhibition of C-MYC transactl vat I on by mad transcription factor interrupts cycling in hepatocellular carcinoma cells (1996) (0)
FoxO Transcription Factors in Brain: Regulation and Behavioral Manifestation (2009) (0)
Up-Regulation of c-Jun contributes to the Induction of Apoptosis by Adaphostin in Human Multiple Myeloma Cells. (2005) (0)
Therapeutic Effects of Metformin The Kinase LKB 1 Mediates Glucose Homeostasis in Liver and (2012) (0)
An inhibitor of oxidative phosphorylation exploits cancer vulnerability (2018) (0)
Abstract LB-290: Telomere dysfunction is a driver of inflammatory bowel disease (2019) (0)
Large Scale Copy Number Variation Upregulates the Expression of MYB in Human T-ALL. (2006) (0)
Yap1 Activation Enables Bypass of Oncogenic Kras Addiction in Pancreatic Cancer (2014) (0)
The power of lifestyle choices (2018) (0)
KRAS-IRF 2 Axis Drives Im mune Suppression and Immune Therapy Resistance in Colorectal Cancer Graphical (2019) (0)
A family of novel TEAD palmitoylation site inhibitors with exceptional pre-clinical anti-neoplastic activity as a monotherapy and in combination with MAPK inhibitors (2022) (0)
Abstract IA27: Context-dependent role of KRAS in GI malignancies (2020) (0)
The familial melanoma gene, INK4a, cooperates with activated RAS in development of melanoma: A mouse model (1998) (0)
Abstract 117: Lysyl oxidase secreted by PTEN-deficient glioblastoma cells recruits macrophages and promotes malignant growth (2018) (0)
Abstract IA24: YAP in cancer and inflammation (2020) (0)
DNA-Dependent Protein Kinase Catalytic Subunit Is Not Required for Dysfunctional Telomere Fusion and Checkpoint Response in the Telomerase-Deﬁcient Mouse (cid:1) (2007) (0)
Abstract 777: Malic enzyme 3 as a collateral lethality target in pancreatic cancer (2018) (0)
Targeting YAP-dependent MDSC infiltration impairs tumor progression (2015) (0)
412 Neuroplastic Changes in a Mouse Model of Pancreatic Ductal Adenocarcinoma (PDAC) (2010) (0)
Erratum: Adiponectin regulates bone mass via opposite central and peripheral mechanisms through FoxO1 (Cell Metabolism (2013) 17 (901-915)) (2014) (0)
Abstract A060: Targeting glioma-macrophage interplay via LOX in PTEN-deficient glioblastoma (2019) (0)
Abstract PR03: Global quantitative proteomic and phosphoproteomic analysis of oncogenic Kras-driven mouse pancreatic cancer (2014) (0)
Modeles de cancer (2003) (0)
Effective combinatorial immunotherapy for penile squamous cell carcinoma (2020) (0)
TMIC-22. DECIPHERING GLIOMA INTRINSIC TRANSCRIPTIONAL SUBTYPES IDENTIFIES TUMOR EVOLUTION ASSOCIATES WITH CHANGES IN IMMUNE-MICROENVIRONMENT (2017) (0)
An enolase inhibitor for the targeted treatment of ENO1-deleted cancers (2020) (0)
The transcription factor FoxO1 is required in endothelial cells for vascular remodeling of the mouse yolk sac (2011) (0)
Synthetic Essentiality of Tryptophan 2 , 3-dioxygenase 2 in APC-Mutated 1 Colorectal Cancer 2 3 (2022) (0)
SUMOylation of ROR-γt inhibits IL-17 expression and inflammation via HDAC2 (2018) (0)
Tu1678 Global Quantitative Proteomic and Phosphoproteomic Analysis of Oncogenic Kras-Driven Mouse Pancreatic Cancer (2014) (0)
Akt/foxo signaling pathway enforces the differentiation blockade in myeloid leukemias (2011) (0)
Suppression of mouse colon tumor angiogenesis by the INK4a/ARF locus (2001) (0)
Author Correction: An enolase inhibitor for the targeted treatment of ENO1-deleted cancers (2020) (0)
Abstract PR4: Neuroplastic changes and pain-related behavior in a transgenic mouse model of pancreatic ductal adenocarcinoma (PDAC). (2012) (0)
Abstract A37: Anti-telomerase therapy provokes ALT and mitochondrial adaptive mechanism in cancer (2012) (0)
Telomere shortening inhibits progression of hepatoma in telomerase deficient mice (2002) (0)
Abstract C183: Pomhex: a cell-permeable high potency Enolase inhibitor with in vivo anti-neoplastic activity (2015) (0)
TMIC-14. AUTO-/PARACRINE SIGNALING OF PI3K/AKT/YKL-40 IN MESENCHYMAL GLIOBLASTOMA PROGRESSION (2018) (0)
The use of deregulated myc expression and dominant interference to study normal cellular differentiation in vivo (1992) (0)
The Challenges of an Aging World Population and the Impact of Science on Controlling the Aging Process and Associated Diseases. (2013) (0)
Genetic depletion of de novo coenzyme A biosynthesis exacerbates puromycin toxicity (2022) (0)
POMHEX, a cell-permeable enolase inhibitor for collateral lethality targeting of ENO1-deleted glioblastoma (2016) (0)
Telomere Dysfunction-Induced DNA Damage Drives Hematopoietic Stem Cell Fate (2015) (0)
Knowledge About the Human Papillomavirus Vaccine Among Employees at a Tertiary Cancer Center: Room for Improvement (2019) (0)
Identification of mSds3, a component of transcriptional repressor complex, as a novel p35-interacting protein (2004) (0)
Abstract IA01: Modeling and understanding tumor biologic mechanisms (2020) (0)
Title: Neuroplastic changes occur early in the development of pancreatic ductal adenocarcinoma (2014) (0)
Metabolic Co-dependencies in the Tumor Microenvironment (2021) (0)
p16INK4a Is a Key Downstream Mediator of the Deleterious Effects of FoxO Deficiency on Maintenance of the Hematopoietic Stem Cell Compartment. (2008) (0)
Identification of differentially regulated gene targets in the Myc and Mad family proteins (1999) (0)
The Role for ink4a in Melanoma Pathogenesis (1998) (0)
Abstract A18: Syndecan-1 is required for oncogenic Kras-driven PDAC tumorigenesis and maintenance (2015) (0)
Abstract 3208: Angiogenesis inhibitors strongly synergize with therapeutics targeting tumor metabolism (2022) (0)
Abstract IA014: Synthetic essentiality identifies TDO2 as a key target in APC-deficient CRC (2022) (0)
Upregulation of c-Jun inhibits proliferation and induces apoptosis via caspase-triggered c-Abl cleavage in human multiple myeloma and other malignancies (2007) (0)
Abstract B52: KRAS-IRF2 axis drives immune suppression and immune therapy resistance in colorectal cancer (2020) (0)
Histone demethylase KDM5D drives sex-specific differences in colorectal cancer (2022) (0)
Pillars Article: A Functional T3 Molecule Associated with a Novel Heterodimer on the Surface of Immature Human Thymocytes. Nature. 1986. 322: 179-181. (2016) (0)
The Role of Forkhead Transcription Factors FoxO1, FoxO3 and FoxO4 in Hematopoiesis and Leukemogenesis. (2005) (0)
Abstract 2831: Collateral lethality: A new target for personalized oncology (2018) (0)
Differential Regulation oftheN-mycGeneinTransfected Cells and Transgenic Mice (1990) (0)
Foxo1 links trafficking and survival of naïve T cells through regulation of L-selectin, Ccr7 and IL-7Rα expression (82.17) (2009) (0)
In Vivo Interactions p57 KIP2 Inhibitor: Cooperative Cyclin D- and E-Dependent Kinases and the (2013) (0)
Upregulation of c-Jun Induces Cell Death Via Caspase-Triggered c-Abl Cleavage in Human Multiple Myeloma. (2006) (0)
Telomere dysfunction cooperates with Werner deficiency to promote premature aging and cancer in mice (2005) (0)
NAD+ biosynthesis as a collateral lethality target for precision oncology (2022) (0)
Severe growth plate abnormalities and increased bone volume in mice with chondrocyte-specific inactivation of Forkhead Box O (FOXO) transcription factors (2011) (0)
Chinese scientists and US leadership in the life sciences (2019) (0)
Abstract SY15-01: Using comparative oncogenomics to guide personalized cancer medicine (2010) (0)
The myc family of nuclear oncoproteins: Structure, biochemistry, and activities (2018) (0)
Abstract IA16: Kras-directed anabolic processes in PDAC tumor maintenance. (2012) (0)
Abstract LB-125: KDM5D as a novel gender-specific gene target for metastatic colorectal cancer (2019) (0)
PENILE CARCINOMA: GENETICALLY ENGINEERED MODELS FOR NOVEL THERAPEUTICS IDENTIFICATION: MP81‐07 (2017) (0)
Abstract A28: USP21 promotes stemness of pancreatic cancer cells and bypass of KRAS extinction (2020) (0)
An Screen Identifies PYGO2 as a Driver for Metastatic Prostate Cancer. (2018) (0)
Forkhead Box O (FoxO) Transcription Factors in the Actions of 1,25-Dihydroxyvitamin D3 on Osteoblasts (2010) (0)
Erratum: The glucocorticoid hormone signal transduction pathway in mice homozygous for chromosomal deletions causing failure of cell type-specific inducible gene expression (Proc. Natl. Acad. Sci. USA (July 1991) 88 (5607-5610)) (1991) (0)
Abstract CT118: A phase I/II trial of a CXCR1/2 inhibitor in combination with anti-PD-1 for circulating tumor DNA (ctDNA) positive & refractoryRAS-mutated microsatellite stable (MSS) colorectal cancer (2023) (0)
Regulation of PI3K signaling and transformation by PTEN C-terminal interacting proteins (2005) (0)
PTEN C-terminal domain suppresses transformation (2005) (0)
Impact papers on aging in 2009 Citation (2022) (0)
ILF2-YB1 Protein Interaction Modulates RNA Splicing to Induce Resistance to Chemotherapy in High Risk Multiple Myeloma (2016) (0)
Activation directe de la kinase activee par l'amp reposant sur l'utilisation de la kinase lkb1, suppresseur de tumeurs (2004) (0)
QnAs with Ronald DePinho. Interview by Prashant Nair. (2013) (0)
2703 PTEN C-terminal domain suppresses transformation (2005) (0)
Structure, expression, and oncogenic activity of the myc gene family (2018) (0)
An interview with Ronald DePinho by Misia Landau. (2013) (0)
Abstract 3837: Passenger deletion of ENO1 as a collateral lethality target in cancer (2016) (0)
A Mouse Model of Telomere Dysfunction Recapitulates Hallmark Features of Human Myelodysplastic Syndrome (2014) (0)
Abstract 6053: Sulfation is required for prostate cancer xenograft tumor formation but is dispensable for cell viabilityin vitro (2023) (0)
Foxo1 links trafficking and survival of naive T cells through regulation of L-selectin, Ccr7 and IL-7R{alpha} expression (2009) (0)
Abstract A09: CD4 T cells mediated protumorigenic pathway in pancreatic cancer (2019) (0)
Abstract 4757: Loss of KDM5A supports KRAS-driven pancreatic cancer (2023) (0)
Targeting T cell checkpoints and myeloid suppressor cells is effective in pancreatic cancer (2023) (0)

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