Ronald Germain

Q: What Schools Are Affiliated With Ronald Germain

Ronald Germain is affiliated with the following schools: Harvard University, University of Western Ontario, University of Lausanne, University of Texas Medical Branch, Chiba University, Royal Postgraduate Medical School, University of Toronto, Columbia University, University of California, San Francisco

Ronald Germain's AcademicInfluence.com Rankings

Ronald Germain

Biology

#3023

World Rank

#4685

Historical Rank

#1279

USA Rank

Cell Biology

#66

World Rank

#70

Historical Rank

#29

USA Rank

Immunology

#123

World Rank

#130

Historical Rank

#41

USA Rank

Molecular Biology

#207

World Rank

#211

Historical Rank

#97

USA Rank

biology Degrees

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Biology

Ronald Germain's Degrees

PhD Immunology University of California, San Francisco
Doctorate Medicine University of California, San Francisco

Why Is Ronald Germain Influential?

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According to Wikipedia, Ronald N. Germain is a scientist at the National Institutes of Health . He was elected a Member of the National Academy of Sciences in 2016.

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Ronald Germain's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

MHC-dependent antigen processing and peptide presentation: Providing ligands for T lymphocyte activation (1994) (1502)
Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy (2016) (1108)
House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells (2009) (1091)
The biochemistry and cell biology of antigen processing and presentation. (1993) (1078)
In Vivo Microbial Stimulation Induces Rapid CD40 Ligand–independent Production of Interleukin 12 by Dendritic Cells and their Redistribution to T Cell Areas (1997) (1049)
Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes. (2006) (935)
IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression. (1993) (930)
T-cell development and the CD4–CD8 lineage decision (2002) (807)
Localization, quantitation, and in situ detection of specific peptide-MHC class I complexes using a monoclonal antibody. (1997) (775)
In Vivo Imaging Reveals an Essential Role for Neutrophils in Leishmaniasis Transmitted by Sand Flies (2008) (762)
Dynamic Imaging of T Cell-Dendritic Cell Interactions in Lymph Nodes (2002) (752)
Chemokines enhance immunity by guiding naive CD8+ T cells to sites of CD4+ T cell–dendritic cell interaction (2006) (751)
The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP (2012) (738)
Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo (2013) (704)
Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagement (2006) (693)
Predominant Role for Directly Transfected Dendritic Cells in Antigen Presentation to CD8+ T Cells after Gene Gun Immunization (1998) (614)
SAP-controlled T-B cell interactions underlie germinal centre formation (2008) (594)
Extrafollicular Activation of Lymph Node B Cells by Antigen-Bearing Dendritic Cells (2006) (526)
The Adaptor MAVS Promotes NLRP3 Mitochondrial Localization and Inflammasome Activation (2013) (517)
Stromal cell contributions to the homeostasis and functionality of the immune system (2009) (492)
Induction of CD8+ cytotoxic T cells by immunization with purified HIV-1 envelope protein in ISCOMs (1990) (484)
The dynamics of T cell receptor signaling: complex orchestration and the key roles of tempo and cooperation. (1999) (474)
TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways (2003) (466)
Modeling T Cell Antigen Discrimination Based on Feedback Control of Digital ERK Responses (2005) (461)
Receptor-Mediated Uptake of Antigen/Heat Shock Protein Complexes Results in Major Histocompatibility Complex Class I Antigen Presentation via Two Distinct Processing Pathways (2000) (455)
The Formation of Immunogenic Major Histocompatibility Complex Class II–Peptide Ligands in Lysosomal Compartments of Dendritic Cells Is Regulated by Inflammatory Stimuli (2000) (448)
Commensal Microbiota Promote Lung Cancer Development via γδ T Cells (2019) (431)
Immunology: The ins and outs of antigen processing and presentations (1986) (415)
Constitutive Presentation of a Natural Tissue Autoantigen Exclusively by Dendritic Cells in the Draining Lymph Node (2002) (413)
Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes (2002) (410)
MHC class II structure, occupancy and surface expression determined by post-endoplasmic reticulum antigen binding (1991) (409)
MHC class II interaction with CD4 mediated by a region analogous to the MHC class I binding site for CD8 (1992) (398)
An immunodominant epitope of the human immunodeficiency virus envelope glycoprotein gp160 recognized by class I major histocompatibility complex molecule-restricted murine cytotoxic T lymphocytes. (1988) (394)
Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis (2009) (387)
Cooperation between CD4+ and CD8+ T cells: when, where, and how. (2006) (385)
The Immune Response Genes of the Major Histocompatibility Complex (1978) (375)
Optimal germinal center responses require a multistage T cell:B cell adhesion process involving integrins, SLAM-associated protein, and CD84. (2010) (362)
Defective major histocompatibility complex class II assembly, transport, peptide acquisition, and CD4+ T cell selection in mice lacking invariant chain expression (1993) (358)
Variability and Robustness in T Cell Activation from Regulated Heterogeneity in Protein Levels (2008) (344)
Global Analyses of Human Immune Variation Reveal Baseline Predictors of Postvaccination Responses (2014) (337)
S1P-dependent interorgan trafficking of group 2 innate lymphoid cells supports host defense (2018) (335)
Macrophage and T cell dynamics during the development and disintegration of mycobacterial granulomas. (2008) (328)
A Decade of Imaging Cellular Motility and Interaction Dynamics in the Immune System (2012) (328)
Histo-cytometry: a method for highly multiplex quantitative tissue imaging analysis applied to dendritic cell subset microanatomy in lymph nodes. (2012) (326)
Major histocompatibility complex class I presentation of peptides derived from soluble exogenous antigen by a subset of cells engaged in phagocytosis (1995) (320)
A Spatially-Organized Multicellular Innate Immune Response in Lymph Nodes Limits Systemic Pathogen Spread (2012) (317)
Natural killer cell behavior in lymph nodes revealed by static and real-time imaging (2006) (313)
CD4 T follicular helper cell dynamics during SIV infection. (2012) (309)
A Systems Analysis Identifies a Feedforward Inflammatory Circuit Leading to Lethal Influenza Infection (2013) (307)
Exclusion of CD43 from the immunological synapse is mediated by phosphorylation-regulated relocation of the cytoskeletal adaptor moesin. (2001) (302)
Dynamic imaging of the immune system: progress, pitfalls and promise (2006) (287)
A Single Major Pathway of T‐Lymphocyte Interactions in Antigen‐Specific Immune Suppression (1981) (282)
A role for peptide in determining MHC class II structure (1991) (281)
Antigen- and cytokine-driven accumulation of regulatory T cells in visceral adipose tissue of lean mice. (2015) (279)
The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate (2000) (278)
A novel lymphocyte function-associated antigen (LFA-1): cellular distribution, quantitative expression, and structure. (1981) (273)
ERM proteins regulate cytoskeleton relaxation promoting T cell–APC conjugation (2004) (270)
Peptide-major histocompatibility complex class II complexes with mixed agonist/antagonist properties provide evidence for ligand-related differences in T cell receptor-dependent intracellular signaling (1993) (261)
T cell-positive selection uses self-ligand binding strength to optimize repertoire recognition of foreign antigens. (2013) (258)
Single Cell Analysis Reveals Regulated Hierarchical T Cell Antigen Receptor Signaling Thresholds and Intraclonal Heterogeneity for Individual Cytokine Responses of CD4+ T Cells (1997) (257)
Monoclonal antibodies against the antigen receptor on a cloned T-cell hybrid. (1983) (256)
Immune homeostasis enforced by co-localized effector and regulatory T cells (2015) (248)
CD28-mediated costimulation of interleukin 2 (IL-2) production plays a critical role in T cell priming for IL-4 and interferon gamma production (1994) (243)
Specific antigen—la activation of transfected human T cells expressing murine Ti αβ —human T3 receptor complexes (1987) (238)
Quantitative Impact of Thymic Clonal Deletion on the T Cell Repertoire (1997) (232)
Chemorepulsion by blood S1P regulates osteoclast precursor mobilization and bone remodeling in vivo (2010) (230)
Unexpectedly complex regulation of CD4/CD8 coreceptor expression supports a revised model for CD4+CD8+ thymocyte differentiation. (1996) (229)
Robust Anti-viral Immunity Requires Multiple Distinct T Cell-Dendritic Cell Interactions (2015) (229)
Strategically localized dendritic cells promote rapid T cell responses to lymph-borne particulate antigens. (2015) (227)
Split anergy in a CD8+ T cell: receptor-dependent cytolysis in the absence of interleukin-2 production. (1991) (223)
Microbiota-Dependent Sequelae of Acute Infection Compromise Tissue-Specific Immunity (2015) (221)
L-selectin-negative CCR7− effector and memory CD8+ T cells enter reactive lymph nodes and kill dendritic cells (2007) (219)
The Efficiency of CD4 Recruitment to Ligand-engaged TCR Controls the Agonist/Partial Agonist Properties of Peptide–MHC Molecule Ligands (1997) (216)
Innate and adaptive lymphocytes sequentially shape the gut microbiota and lipid metabolism (2018) (212)
Intravital imaging reveals limited antigen presentation and T cell effector function in mycobacterial granulomas. (2011) (211)
Efficient cell surface expression of class II MHC molecules in the absence of associated invariant chain (1986) (206)
CD8+ T Cells Orchestrate pDC‐XCR1+ Dendritic Cell Spatial and Functional Cooperativity to Optimize Priming (2017) (206)
Extensive trafficking of MHC class II-invariant chain complexes in the endocytic pathway and appearance of peptide-loaded class II in multiple compartments. (1995) (206)
Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage (2019) (202)
T-cell-receptor-dependent signal intensity dominantly controls CD4(+) T cell polarization In Vivo. (2014) (201)
Divergent changes in the sensitivity of maturing T cells to structurally related ligands underlies formation of a useful T cell repertoire. (1999) (200)
Superpenetration optical microscopy by iterative multiphoton adaptive compensation technique (2012) (199)
Multiplex, quantitative cellular analysis in large tissue volumes with clearing-enhanced 3D microscopy (Ce3D) (2017) (196)
The Art of the Probable: System Control in the Adaptive Immune System (2001) (195)
The CLIP region of invariant chain plays a critical role in regulating major histocompatibility complex class II folding, transport, and peptide occupancy (1994) (195)
Characterization of T cell receptor gamma chain expression in a subset of murine thymocytes. (1986) (194)
Tuning of antigen sensitivity by T cell receptor-dependent negative feedback controls T cell effector function in inflamed tissues. (2014) (193)
Fibroblastic Reticular Cells Guide T Lymphocyte Entry into and Migration within the Splenic T Cell Zone1 (2008) (187)
Relationships among TCR ligand potency, thresholds for effector function elicitation, and the quality of early signaling events in human T cells. (1998) (182)
CD4+ T cell survival is not directly linked to self-MHC–induced TCR signaling (2000) (182)
Systems biology in immunology: a computational modeling perspective. (2011) (174)
Thy-1 functions as a signal transduction molecule in T lymphocytes and transfected B lymphocytes (1986) (173)
Peripheral prepositioning and local CXCL9 chemokine-mediated guidance orchestrate rapid memory CD8+ T cell responses in the lymph node. (2013) (168)
Peptide binding inhibits protein aggregation of invariant-chain free class II dimers and promotes surface expression of occupied molecules (1993) (168)
Production, specificity, and functionality of monoclonal antibodies to specific peptide-major histocompatibility complex class II complexes formed by processing of exogenous protein. (1997) (162)
Protective T cell immunity in mice following protein-TLR7/8 agonist-conjugate immunization requires aggregation, type I IFN, and multiple DC subsets. (2011) (162)
Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis. (2020) (159)
Information transfer at the immunological synapse (2000) (156)
Antigen- and receptor-driven regulatory mechanisms. IV. Idiotype- bearing I-J+ suppressor T cell factors induce second-order suppressor T cells which express anti-idiotypic receptors (1980) (156)
A single amino acid interchange yields reciprocal CTL specificities for HIV-1 gp160. (1989) (156)
Relationship between invariant chain expression and major histocompatibility complex class II transport into early and late endocytic compartments (1993) (155)
Related Leucine-based Cytoplasmic Targeting Signals in Invariant Chain and Major Histocompatibility Complex Class II Molecules Control Endocytic Presentation of Distinct Determinants in a Single Protein (1997) (152)
T-cell signaling: The importance of receptor clustering (1997) (148)
Serial TCR engagement and down-modulation by peptide:MHC molecule ligands: relationship to the quality of individual TCR signaling events. (1999) (146)
Thy-1-mediated T-cell activation requires co-expression of CD3/Ti complex (1987) (145)
Analysis of adjuvant function by direct visualization of antigen presentation in vivo: endotoxin promotes accumulation of antigen-bearing dendritic cells in the T cell areas of lymphoid tissue. (1999) (145)
Continuous volumetric imaging via an optical phase-locked ultrasound lens (2015) (145)
Induction of broadly cross-reactive cytotoxic T cells recognizing an HIV-1 envelope determinant. (1992) (145)
Dynamic visualization of RANKL and Th17-mediated osteoclast function. (2013) (144)
Highways, byways and breadcrumbs: directing lymphocyte traffic in the lymph node. (2007) (144)
Antigen-unspecific B Cells and Lymphoid Dendritic Cells Both Show Extensive Surface Expression of Processed Antigen–Major Histocompatibility Complex Class II Complexes after Soluble Protein Exposure In Vivo or In Vitro (1997) (143)
Shared idiotypic determinants on antibodies and T-cell-derived suppressor factor specific for the random terpolymer L-glutamic acid60- L-alanine30-L-tyrosine10 (1979) (141)
The multiple faces of leukocyte interstitial migration (2014) (141)
DOCK8 regulates lymphocyte shape integrity for skin antiviral immunity (2014) (139)
Quantification of lymph node transit times reveals differences in antigen surveillance strategies of naïve CD4+ and CD8+ T cells (2012) (138)
Key Role of Local Regulation in Chemosensing Revealed by a New Molecular Interaction-Based Modeling Method (2006) (138)
Antigen presentation by MHC class II molecules: invariant chain function, protein trafficking, and the molecular basis of diverse determinant capture. (1997) (138)
MHC class II function preserved by low-affinity peptide interactions preceding stable binding (1994) (133)
Nucleotide sequence and expression of a mouse interleukin 2 receptor cDNA. (1985) (132)
Involvement of both major histocompatibility complex class II alpha and beta chains in CD4 function indicates a role for ordered oligomerization in T cell activation (1995) (130)
An innately interesting decade of research in immunology (2004) (129)
Spatiotemporal basis of innate and adaptive immunity in secondary lymphoid tissue. (2014) (128)
Follicular CD8 T cells accumulate in HIV infection and can kill infected cells in vitro via bispecific antibodies (2017) (128)
Partial signaling by CD8+ T cells in response to antagonist ligands (1996) (128)
Peptide and beta 2-microglobulin regulation of cell surface MHC class I conformation and expression. (1992) (127)
Expression of genes of the T-cell antigen receptor complex in precursor thymocytes (1985) (126)
Allelic differences affecting invariant chain dependency of MHC class II subunit assembly. (1995) (125)
Excess β2 microglobulin promoting functional peptide association with purified soluble class I MHC molecules (1991) (125)
Dendritic cell and antigen dispersal landscapes regulate T cell immunity (2017) (120)
Hapten-specific T-cell responses to 4-hydroxy-3-nitrophenyl acetyl. II. Demonstration of idiotypic determinants on suppressor T cells (1979) (119)
The importance of dominant negative effects of amino acid side chain substitution in peptide-MHC molecule interactions and T cell recognition. (1993) (119)
Visualization and Identification of IL-7 Producing Cells in Reporter Mice (2009) (116)
An immunodominant class I-restricted cytotoxic T lymphocyte determinant of human immunodeficiency virus type 1 induces CD4 class II-restricted help for itself (1990) (116)
Variant TCR ligands: new insights into the molecular basis of antigen-dependent signal transduction and T-cell activation. (1996) (113)
A Tunable Diffusion‐Consumption Mechanism of Cytokine Propagation Enables Plasticity in Cell‐to‐Cell Communication in the Immune System (2017) (113)
B-cell follicle development remodels the conduit system and allows soluble antigen delivery to follicular dendritic cells. (2009) (111)
Cross-antagonism of a T cell clone expressing two distinct T cell receptors. (1999) (111)
Direct delivery of exogenous MHC class I molecule-binding oligopeptides to the endoplasmic reticulum of viable cells. (1997) (110)
Development of mature CD8+ thymocytes: selection rather than instruction? (1993) (107)
Allele-specific control of Ia molecule surface expression and conformation: implications for a general model of Ia structure-function relationships. (1987) (106)
A molecular map of T cell development. (1998) (105)
Serum angiotensin-1 converting enzyme activity processes a human immunodeficiency virus 1 gp160 peptide for presentation by major histocompatibility complex class I molecules (1992) (105)
Immune complexes stimulate CCR7-dependent dendritic cell migration to lymph nodes (2014) (104)
Processing and Presentation of Endocytically Acquired Protein Antigens by MHC Class II and Class I Molecules (1996) (104)
Influence of allelic polymorphism on the assembly and surface expression of class II MHC (Ia) molecules (1985) (103)
Immune regulation by glucocorticoids can be linked to cell type–dependent transcriptional responses (2019) (103)
Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis (2010) (101)
Rearrangement and transcription of a T-cell receptor beta-chain gene in different T-cell subsets. (1985) (101)
Murine I-A beta chain polymorphism: nucleotide sequences of three allelic I-A beta genes. (1983) (99)
Structural requirements for class I MHC molecule-mediated antigen presentation and cytotoxic T cell recognition of an immunodominant determinant of the human immunodeficiency virus envelope protein (1989) (99)
Unexpected expression of a unique mixed-isotype class II MHC molecule by transfected L-cells (1986) (99)
Cytolytic thymus-derived lymphocytes specific for allogeneic stimulator cells crossreact with chemically modified syngeneic cells. (1977) (98)
Thy-1+ dendritic epidermal cells belong to the T-cell lineage. (1987) (97)
Interleukin 2 production, not the pattern of early T-cell antigen receptor-dependent tyrosine phosphorylation, controls anergy induction by both agonists and partial agonists. (1996) (96)
Analysis of the expression and function of class-II major histocompatibility complex-encoded molecules by DNA-mediated gene transfer. (1986) (95)
Cancer-associated epithelial cell adhesion molecule (EpCAM; CD326) enables epidermal Langerhans cell motility and migration in vivo (2012) (93)
Functionally distinct subsites on a class II major histocompatibility complex molecule (1987) (93)
Lymph-Node Resident CD8α+ Dendritic Cells Capture Antigens from Migratory Malaria Sporozoites and Induce CD8+ T Cell Responses (2015) (92)
Thy-1- and Ly-6-mediated lymphokine production and growth inhibition of a T cell hybridoma require co-expression of the T cell antigen receptor complex. (1988) (92)
Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. V. Role of idiotypes in the suppressor pathway (1980) (92)
Invariant chain promotes egress of poorly expressed, haplotype-mismatched class II major histocompatibility complex A alpha A beta dimers from the endoplasmic reticulum/cis-Golgi compartment. (1991) (91)
Computational Modeling of Cellular Signaling Processes Embedded into Dynamic Spatial Contexts (2012) (90)
In vivo antigen presentation. (2004) (88)
Making friends in out‐of‐the‐way places: how cells of the immune system get together and how they conduct their business as revealed by intravital imaging (2008) (88)
Illuminating the landscape of in vivo immunity: insights from dynamic in situ imaging of secondary lymphoid tissues. (2004) (87)
Vaccines and the future of human immunology. (2010) (86)
Selective Induction of Apoptosis in Mature T Lymphocytes by Variant T Cell Receptor Ligands (1998) (85)
Membrane Ia expression and antigen-presenting accessory cell function of L cells transfected with class II major histocompatibility complex genes (1984) (85)
Dissociation of phosphoinositide hydrolysis and Ca2+ fluxes from the biological responses of a T-cell hybridoma (1988) (85)
Qualitative and quantitative studies of antigen-presenting cell function by using I-A-expressing L cells. (1985) (85)
Commensal-driven immune zonation of the liver promotes host defence (2020) (85)
Evidence that binding site occupancy is necessary and sufficient for effective major histocompatibility complex (MHC) class II transport through the secretory pathway redefines the primary function of class II-associated invariant chain peptides (CLIP) (1996) (84)
Quantitative challenges in understanding ligand discrimination by αβ T cells (2008) (83)
Induction of macrophage Ia antigen expression by rIFN-gamma and down-regulation by IFN-alpha/beta and dexamethasone are mediated by changes in steady-state levels of Ia mRNA. (1987) (83)
Large protein fragments as substrates for endocytic antigen capture by MHC class II molecules. (1998) (80)
Chemokine-Guided CD4+ T Cell Help Enhances Generation of IL-6RαhighIL-7Rαhigh Prememory CD8+ T Cells1 (2007) (80)
Spatial distribution and function of T follicular regulatory cells in human lymph nodes (2018) (79)
Regulatory T Cells Selectively Control CD8+ T Cell Effector Pool Size via IL-2 Restriction (2011) (79)
An epitope in human immunodeficiency virus 1 reverse transcriptase recognized by both mouse and human cytotoxic T lymphocytes. (1990) (79)
Revisiting thymic positive selection and the mature T cell repertoire for antigen. (2014) (79)
Accessory cell stimulation of T cell proliferation requires active antigen processing, Ia-restricted antigen presentation, and a separate nonspecific 2nd signal. (1981) (78)
Spatial mapping of protein composition and tissue organization: a primer for multiplexed antibody-based imaging (2021) (78)
Distinct NF-κB and MAPK Activation Thresholds Uncouple Steady-State Microbe Sensing from Anti-pathogen Inflammatory Responses. (2016) (77)
High-dimensional cell-level analysis of tissues with Ce3D multiplex volume imaging (2019) (77)
"Exon-shuffling" maps control of antibody- and T-cell-recognition sites to the NH2-terminal domain of the class II major histocompatibility polypeptide A beta. (1985) (77)
High endothelial venules as traffic control points maintaining lymphocyte population homeostasis in lymph nodes. (2011) (77)
How MHC class II molecules work: peptide-dependent completion of protein folding. (1992) (76)
Enhancement of carrier-specific helper T cell function by the synthetic adjuvant, N-acetyl muramyl-L-alanyl-D-isoglutamine (MDP). (1978) (76)
Maintaining system homeostasis: the third law of Newtonian immunology (2012) (74)
Structure-function analysis of the Abm12 beta mutation using site-directed mutagenesis and DNA-mediated gene transfer. (1987) (72)
The T Cell Receptor for Antigen: Signaling and Ligand Discrimination* (2001) (72)
Antigen-specific T cell-mediated suppression. IV. Role of macrophages in generation of L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT)-specific suppressor T cells in responder mouse strains. (1978) (71)
Structurally interdependent and independent regions of allelic polymorphism in class II MHC molecules. Implications for Ia function and evolution. (1990) (70)
On the role of self‐recognition in T cell responses to foreign antigen (2003) (69)
Network representations of immune system complexity (2015) (69)
Special regulatory T‐cell review: A rose by any other name: from suppressor T cells to Tregs, approbation to unbridled enthusiasm (2008) (69)
Lipid-gated monovalent ion fluxes regulate endocytic traffic and support immune surveillance (2019) (68)
Antigen- and receptor-driven regulatory mechanisms. VIII. Suppression of idiotype-negative, p-azobenzenearsonate-specific T cells results from the interaction of an anti-idiotypic second-order T suppressor cell with a cross-reactive-idiotype-positive, p-azobenzenearsonate- primed T cell target (1981) (67)
Cross-reactive lysis of trinitrophenyl (TNP)-derivatized H-2 incompatible target cells by cytolytic T lymphocytes generated against syngeneic TNP spleen cells (1976) (67)
Inhibition of cell-mediated cytolysis of trinitrophenyl-derivatized target cells by alloantisera directed to the products of the K and D loci of the H-2 complex. (1976) (66)
The Chemoattractant Receptor Ebi2 Drives Intranodal Naive CD4+ T Cell Peripheralization to Promote Effective Adaptive Immunity. (2019) (65)
Thymocyte resistance to glucocorticoids leads to antigen-specific unresponsiveness due to "holes" in the T cell repertoire. (2000) (64)
Navigating the network: signaling cross-talk in hematopoietic cells (2009) (63)
A Plaidoyer for ‘Systems Immunology’ (2006) (63)
An extended vision for dynamic high-resolution intravital immune imaging. (2005) (63)
The Biochemistry and Cell Biology of Antigen Presentation by MHC Class I and Class II Molecules (1995) (63)
Imaging of T‐cell interactions with antigen presenting cells in culture and in intact lymphoid tissue (2002) (62)
NK-DC crosstalk controls the autopathogenic Th17 response through an innate IFN-γ–IL-27 axis (2015) (62)
Marked differences in the efficiency of expression of distinct alpha beta T cell receptor heterodimers. (1989) (62)
MHC class I surface expression in embryo-derived cell lines inducible with peptide or interferon (1991) (62)
Tissue clonality of dendritic cell subsets and emergency DCpoiesis revealed by multicolor fate mapping of DC progenitors (2019) (62)
Hyperactivated PI3Kδ promotes self and commensal reactivity at the expense of optimal humoral immunity (2018) (61)
Early genetic events in T cell development analyzed by in situ hybridization (1987) (60)
Immunologic effects of whole-body ultraviolet irradiation: selective defect in splenic adherent cell function in vitro. (1980) (60)
Antigen processing and CD4+ T cell depletion in AIDS (1988) (59)
Memory-phenotype CD4+ T cells spontaneously generated under steady-state conditions exert innate TH1-like effector function (2017) (59)
Specific and nonspecific antitumor immunity. II. Macrophage-mediated nonspecific effector activity induced by BCG and similar agents. (1975) (59)
Predictable acquisition of a new MHC recognition specificity following expression of a transfected T-cell receptor β-chain gene (1987) (58)
Antigen-Specific T Cell-Mediated Suppression (1978) (56)
Processing of a minimal antigenic peptide alters its interaction with MHC molecules (1988) (56)
Antigen- and receptor-driven regulatory mechanisms. VII. H-2-restricted anti-idiotypic suppressor factor from efferent suppressor T cells (1981) (56)
T-cell recognition of a chimaeric class II/class I MHC molecule and the role of L3T4 (1985) (56)
TCR Signaling for Initiation and Completion of Thymocyte Positive Selection Has Distinct Requirements for Ligand Quality and Presenting Cell Type (2000) (56)
B-lymphocyte responses to trinitrophenyl-conjugated Ficoll: requirement for T lymphocytes and Ia-bearing adherent cells. (1981) (54)
In vivo effects of anti-Ia alloantisera. I. Elimination of specific suppression by in vivo administration of antisera specific for I-J controlled determinants (1978) (54)
IBEX: A versatile multiplex optical imaging approach for deep phenotyping and spatial analysis of cells in complex tissues (2020) (53)
Adjuvant and carrier protein-dependent T-cell priming promotes a robust antibody response against the Plasmodium falciparum Pfs25 vaccine candidate (2017) (53)
Transient Aggregation of Major Histocompatibility Complex Class II Chains during Assembly in Normal Spleen Cells (*) (1995) (52)
The molecular basis of class II MHC allelic control of T cell responses. (1991) (51)
Cell surface T3 expression requires the presence of both alpha- and beta-chains of the T cell receptor. (1987) (51)
Defective intracellular transport as a common mechanism limiting expression of inappropriately paired class II major histocompatibility complex alpha/beta chains (1991) (51)
Antigen-Specific T Cell-Mediated Suppression: III. Induction of Antigen-Specific Suppressor T Cells (TS2) in L-Glutamic Acid60-L-Alanine30-L-Tyrosine10 (GAT) Responder Mice by Nonresponder-Derived GAT-Suppressor Factor (GAT-TSF) (1978) (51)
AS03-adjuvanted H5N1 vaccine promotes antibody diversity and affinity maturation, NAI titers, cross-clade H5N1 neutralization, but not H1N1 cross-subtype neutralization (2018) (51)
Opening a Window on Thymic Positive Selection: Developmental Changes in the Influence of Cosignaling by Integrins and CD28 on Selection Events Induced by TCR Engagement (2000) (50)
Distinct contributions of different CD40 TRAF binding sites to CD154‐induced dendritic cell maturation and IL‐12 secretion (2003) (50)
The transmembrane segment of invariant chain mediates binding to MHC class II molecules in a CLIP‐independent manner (2001) (50)
Prime and target immunization protects against liver-stage malaria in mice (2017) (50)
Functional expression of a transfected murine class II MHC gene (1983) (50)
Diminished antigen processing by endosomal acidification mutant antigen-presenting cells. (1989) (49)
Predominant role of amino-terminal sequences in dictating efficiency of class II major histocompatibility complex alpha beta dimer expression. (1987) (49)
Faculty Opinions recommendation of Human placenta has no microbiome but can contain potential pathogens. (2019) (49)
Neutrophils self-limit swarming to contain bacterial growth in vivo (2021) (49)
Chemokine-guided CD4+ T cell help enhances generation of IL-6RalphahighIL-7Ralpha high prememory CD8+ T cells. (2007) (47)
The structural basis of CD4-MHC class II interactions: coreceptor contributions to T cell receptor antigen recognition and oligomerization-dependent signal transduction. (1996) (47)
I-A-restricted T cell antigen recognition. Analysis of the roles of A alpha and A beta using DNA-mediated gene transfer (1986) (45)
Surface expression of only gamma delta and/or alpha beta T cell receptor heterodimers by cells with four (alpha, beta, gamma, delta) functional receptor chains (1988) (45)
Analysis of Ir gene function using monoclonal antibodies: independent regulation of GAT and GLPhe T cell responses by I-A and I-E subregion products on a single accessory cell population. (1981) (44)
Seeing is believing: A focus on the contribution of microscopic imaging to our understanding of immune system function (2007) (44)
The role of Ia molecules in the activation of T lymphocytes. II. Ia-restricted recognition of allo K/D antigens is required for class I MHC-stimulated mixed lymphocyte responses. (1983) (41)
Quantifying cellular interaction dynamics in 3D fluorescence microscopy data (2009) (40)
Role of syngeneic Ia+ accessory cells in the generation of allospecific CTL responses. (1982) (40)
Co-stimulatory function in primary germinal center responses: CD40 and B7 are required on distinct antigen-presenting cells (2017) (40)
CD2 can mediate TCR/CD3-independent T cell activation. (1991) (40)
Host conditioning with IL-1β improves the antitumor function of adoptively transferred T cells (2019) (40)
Quantitative challenges in understanding ligand discrimination by alphabeta T cells. (2008) (39)
Peptides corresponding to CD4-interacting regions of murine MHC class II molecules modulate immune responses of CD4+ T lymphocytes in vitro and in vivo. (1996) (38)
MHC-dependent survival of naïve T cells? A complicated answer to a simple question. (2002) (38)
The complete sequences of plasmids pFNeo and pMH-Neo: convenient expression vectors for high-level expression of eukaryotic genes in hematopoietic cell lines. (1993) (37)
The mouse E beta 2 gene: a class II MHC beta gene with limited intraspecies polymorphism and an unusual pattern of transcription. (1986) (36)
Suppression of lethal autoimmunity by regulatory T cells with a single TCR specificity (2017) (36)
The lymph node at a glance – how spatial organization optimizes the immune response (2020) (36)
Structural and functional studies of HLA-DR restricted antigen recognition by human helper T lymphocyte clones by using transfected murine cell lines. (1988) (36)
Extensive polymorphism surrounding the murine Ia A beta chain gene. (1983) (36)
Intracellular competition for component chains determines class II MHC cell surface phenotype (1989) (35)
Comparison of MHC genes among distantly related members of the genus Mus. (1985) (35)
Loss of Ia-bearing splenic adherent cells after whole body ultraviolet irradiation. (1980) (35)
Fine specificity of antibodies to poly(Glu60Ala30Tyr10) produced by hybrid cell lines. (1979) (35)
Feedback suppression of the immune response in vitro. I. Activity of antigen-stimulated B cells (1980) (35)
ILC2s - resident lymphocytes pre-adapted to a specific tissue or migratory effectors that adapt to where they move? (2019) (35)
Secondary antibody responses in vitro to L-glutamic acid60-L-alanine30- L-tyrosine10 (GAT) by (responder X nonresponder)F1 spleen cells stimulated by parental GAT-macrophages (1977) (35)
A local regulatory T cell feedback circuit maintains immune homeostasis by pruning self-activated T cells (2021) (34)
T cell heterogeneity: firmly fixed, predominantly plastic or merely malleable? (2008) (34)
Inhibition of invariant chain (Ii)-calnexin interaction results in enhanced degradation of Ii but does not prevent the assembly of alpha beta Ii complexes (1995) (34)
Presentation of antigen by mixed isotype class II molecules in normal H- 2d mice (1992) (33)
The future of immunoimaging — Deeper, bigger, more precise, and definitively more colorful (2013) (33)
Migrating Myeloid Cells Sense Temporal Dynamics of Chemoattractant Concentrations (2017) (33)
The Murine Interleukin‐2 Receptor: Biochemical Structure and Regulation of Expression (1986) (32)
T-cell recognition of Ia molecules selectively altered by a single amino acid substitution. (1986) (32)
Decreased CD4 expression by polarized T helper 2 cells contributes to suboptimal TCR‐induced phosphorylation and reduced Ca2+ signaling (2005) (32)
The race for the prize: T-cell trafficking strategies for optimal surveillance. (2012) (32)
Acquisition of syngeneic I-A determinants by T cells proliferating in response to poly (Glu60Ala30Tyr10). (1981) (32)
Feedback suppression of the immune response in vitro. II. IgVH- restricted antibody-dependent suppression (1980) (31)
A single monoclonal anti-Ia antibody inhibits antigen-specific T cell proliferation controlled by distinct Ir genes mapping in different H-2 I subregions. (1982) (31)
Immunologic effects of whole body ultraviolet (UV) irradiation. II. Defect in splenic adherent cell antigen presentation for stimulation of T cell proliferation. (1980) (31)
Antigen presentation and related immunological aspects of HIV-1 vaccines. (1998) (30)
Binding domain regulation of MHC class II molecule assembly, trafficking, fate, and function. (1995) (30)
Evidence for lineage commitment and initiation of positive selection by thymocytes with intermediate surface phenotypes. (1995) (30)
The second class story (1991) (29)
Helper and suppressor T cell factors (1980) (28)
The Generation and Selection of the T Cell Repertoire: Insights from Studies of the Molecular Basis of T Cell Recognition (1988) (28)
The in situ dynamics of dendritic cell interactions (2010) (27)
Self-recognition and the regulation of CD4+ T cell survival. (2002) (27)
Robust control of the adaptive immune system. (2017) (27)
Potentiation of a primary in vivo antibody response by alloantisera against gene products of the I region of the H-2 complex. (1977) (27)
Idiotypic analysis of monoclonal antibodies to poly(Glu60Ala30Tyr10). (1979) (27)
Cancer prognosis with shallow tumor RNA sequencing (2020) (27)
Activation properties of T cell receptor-gamma delta hybridomas expressing diversity in both gamma- and delta-chains. (1988) (27)
Specific suppressor responses to antigen under I region control. (1979) (26)
Suppressor factor from a T cell hybrid inhibits delayed-type hypersensitivity responses to azobenzenearsonate. (1981) (26)
Trafficking of a Dual-Modality Magnetic Resonance and Fluorescence Imaging Superparamagnetic Iron Oxide-Based Nanoprobe to Lymph Nodes (2011) (25)
Tissue-specific expression of messenger RNAs encoding endogenous viral superantigens. (1994) (25)
Influence of accessory cell and T cell surface antigens on mitogen-induced IL 2 receptor expression. (1985) (25)
Functional expression of the murine Thy-1.2 gene in transfected human T cells (1986) (24)
Making a molecular match (1990) (24)
Quantifying in situ adaptive immune cell cognate interactions in humans (2019) (24)
Specific antigen-Ia activation of transfected human T cells expressing murine Ti alpha beta-human T3 receptor complexes. (1987) (23)
Responses to the H–2Kba mutant involve recognition of syngeneic Ia molecules (1983) (23)
Specific and nonspecific antitumor immunity. I. Description of an in vitro assay based on inhibition of DNA synthesis in tumor cells. (1975) (23)
Healing the NIH-Funded Biomedical Research Enterprise (2015) (23)
Global Analyses of Human Immune Variation Reveal Baseline Predictors of Postvaccination Responses (2014) (22)
Biologic activity of an idiotype-bearing suppressor T cell factor produced by a long-term T cell hybridoma. (1982) (22)
Single Cell Analysis Reveals Regulated Hierarchical T Cell Antigen Receptor Signaling Thresholds and Intraclonal Heterogeneity for Individual Cytokine Responses of CD 4 1 T Cells (1997) (22)
Cell surface expression of hybrid murine/human MHC class II beta alpha dimers. Key influence of residues in the amino-terminal portion of the beta 1 domain. (1990) (22)
The human condition: an immunological perspective (2011) (21)
Pathogen-Related Differences in the Abundance of Presented Antigen Are Reflected in CD4+ T Cell Dynamic Behavior and Effector Function in the Lung (2014) (21)
A subtractive PCR-based cDNA library made from fetal thymic stromal cells. (1998) (21)
Cell surface expression of an in vitro recombinant class II/class I major histocompatibility complex gene product (1985) (19)
The regulation of the immune system. (1984) (19)
Thinking differently about ILCs—Not just tissue resident and not just the same as CD4+ T‐cell effectors (2018) (19)
Immune responses to complex protein antigens I. MHC control of immune responses to bovine albumin. (1982) (19)
Computational analysis of T cell receptor signaling and ligand discrimination – Past, present, and future (2010) (18)
Idiotypic analysis of anti-GAT antibodies. VI. Identification and strain distribution of the GA-1 idiotype. (1979) (18)
The contribution of mutant amino acids to alloantigenicity (1989) (18)
Recent progress using systems biology approaches to better understand molecular mechanisms of immunity. (2013) (18)
IgE response to synthetic polypeptide antigens. II. Idiotypic analysis of the IgE response to L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT). (1980) (17)
Will Systems Biology Deliver Its Promise and Contribute to the Development of New or Improved Vaccines? What Really Constitutes the Study of "Systems Biology" and How Might Such an Approach Facilitate Vaccine Design. (2018) (17)
Serum Angiotensin-1 Conver~_'ng Enzyme Activity Processes a Human Immunodeficiency Virus 1 gp160 Peptide for Presentation by Major Histocompatibility Complex Class I Molecules By Steven Kozlowski,* Maripat Corr,* Toshiyuki Takeshita,$ (1992) (16)
Idiotypic analysis of anti-GAT antibodies. VII. Common idiotype on hybridoma antibodies to poly(Glu60 Ala40) (1980) (16)
Tuning T cell receptor sensitivity through catch bond engineering (2022) (16)
Perspectives for computer modeling in the study of T cell activation. (2010) (16)
Ligand-dependent regulation of T cell development and activation (2003) (16)
Antigen and receptor-driven regulatory mechanisms. VI. Demonstration of cross-reactive idiotypic determinants on azobenzenearsonate-specific antigen-binding suppressor T cells producing soluble suppressor factor(s). (1980) (16)
An interactive web-based application for Comprehensive Analysis of RNAi-screen Data (2016) (16)
The involvement of suppressor T cells in Ir gene regulation of secondary antibody responses of primed (responder X nonresponder)F1 mice to macrophage-bound L-glutamic acid60-L-alanine30-L-tyrosine (1978) (16)
A New Year for Immunity (2005) (16)
The role of dendritic cells in the initiation of host resistance to Toxoplasma gondii. (1998) (15)
Allergen-Induced CD4+ T Cell Cytokine Production within Airway Mucosal Dendritic Cell–T Cell Clusters Drives the Local Recruitment of Myeloid Effector Cells (2017) (15)
Immunologic effects of whole-body ultraviolet (uv) irradiation. III Defective splenic adherent cell function in alloantigen-stimulated T-cell proliferation. (1981) (15)
Visualization and dynamic analysis of host-pathogen interactions. (2014) (14)
Computational reconstruction of cell and tissue surfaces for modeling and data analysis (2009) (14)
The different roles of MHC class recognition in thymocyte CD4 versus CD8 lineage commitment and positive selection. (1994) (14)
DNA origami patterning of synthetic T cell receptors reveals spatial control of the sensitivity and kinetics of signal activation (2021) (14)
Comparison of thymocyte development in normal and invariant chain-deficient mice provides evidence that maturation-related changes in TCR and co-receptor levels play a critical role in cell fate. (1996) (14)
IBEX: an iterative immunolabeling and chemical bleaching method for high-content imaging of diverse tissues (2022) (13)
Uncovering the Role of Invariant Chain in Controlling MHC Class II Antigen Capture (2011) (13)
Role of I-region gene products in T cell activation. I. Stimulation of T lymphocyte proliferative responses by subcellular membrane preparations containing Ia alloantigens. (1982) (13)
Antigen-specific T cell-mediated suppression. II. In vitro induction by I-J-coded L-glutamic acid50-L-tyrosine50 (GT)-specific T cell suppressor factor (GT-T8F) of suppressor T cells (T82) bearing distinct I-J determinants. (1978) (13)
Targeted Proteomics-Driven Computational Modeling of Macrophage S1P Chemosensing* (2015) (13)
T-cell Activation: The Power of One (2003) (13)
Idiotypic analysis of anti-GAT antibodies. VIII. Comparison of interstrain and allotype-associated idiotypic specificities. (1981) (12)
Modern Concepts in Immune Recognition and Lymphocyte Activation: Relevance for the Development of Useful Vaccines (1994) (12)
correction: The duration of antigen receptor signalling determines CD4 + versus CD8+ T-cell lineage fate (2000) (12)
Transfected human B lymphoblastoid cells express the mouse Ad beta-chain in association with DR alpha. (1986) (12)
Life and death as a T lymphocyte: from immune protection to HIV pathogenesis (2009) (11)
IgE responses to synthetic polypeptide antigens. I. Simultaneous Ir gene and isotype-specific regulation of IgE responses to L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT). (1979) (10)
House dust mite allergen induces asthma via TLR 4 triggering of airway structural cells (2009) (10)
Intubation-free in vivo imaging of the tracheal mucosa using two-photon microscopy (2017) (10)
Cell surface expression of the amino-terminal domain of A kappa alpha. Recognition of an isolated MHC antigenic structure by allospecific T cells but not alloantibodies. (1988) (10)
IFN-mediated negative feedback supports bacteria class-specific macrophage inflammatory responses (2019) (10)
Antigen-specific T cell-mediated suppression. V. H-2-linked genetic control of distinct antigen-specific defects in the production and activity of L-glutamic acid50-L-tyrosine50 suppressor factor (1980) (10)
Age-related differences in immune dynamics during SARS-CoV-2 infection in rhesus macaques (2021) (10)
Induction by i-j-coded l-glutamic acid50-l-tyrosine50 (gt)- -specific t cell suppressor factor (gt-tsf) of suppressor t cells (ts2) bearing distinct i-j determinants. (1978) (10)
Antigen specific T cell-mediated suppression. VI. Properties of in vitro generated L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT)-specific T-suppressor factor(s) (GAT-TsF) in responder mouse strains. (1979) (9)
T-cell repertoire: Political correctness in the immune system (1996) (9)
The molecular basis of antigen presentation. (1988) (8)
Gut Helicobacter presentation by multiple dendritic cell subsets enables context-specific regulatory T cell generation (2021) (8)
T cell subset-selective IL2RA enhancers shape autoimmune diabetes risk (2020) (8)
Focusing in on T Cell Cross-Reactivity (2014) (8)
The molecular basis of MHC-restricted antigen recognition by T cells. (1988) (8)
Spatial meta-transcriptomics reveal associations of intratumor bacteria burden with lung cancer cells showing a distinct oncogenic signature (2022) (7)
In Vivo Intradermal Delivery of Bacteria by Using Microneedle Arrays (2018) (7)
How Can Systems Biology Test Principles and Tools Using Immune Cells as a Model? (2018) (6)
Imaging dynamic interactions in immune responses. (2005) (6)
Modified T-cell receptor ligands: moving beyond a strict occupancy model for T-cell activation by antigen. (1995) (6)
TGF-β regulates the stem-like state of PD-1+ TCF-1+ virus-specific CD8 T cells during chronic infection (2022) (6)
NCI Think-Tank Meeting Report on Proteomic Cartography and Biomarkers at the Single-Cell Level: Interrogation of Premalignant Lesions. (2020) (6)
Genetic and cellular factors in the immune response. 3. The cellular response to poly(Glu52Lys33Tyr15) in the highly responding ACI and poorly responding F344 strains of inbred rats. (1971) (5)
Structure and function of murine class II major histocompatibility complex genes. (1986) (5)
Plaque-forming cell responses to trinitrophenyl (TNP)-L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT) in microcultures are not under conventional Ir gene control. (1981) (4)
Class II essential for CD4 survival - Response (2001) (4)
Specific and nonspecific antitumor immunity. III. Specific T lymphocyte-mediated cytolysis of P815 mastocytoma and SL2 lymphoma by draining lymph node cells from syngeneic tumor-bearing DBA/2J mice. (1976) (4)
Open questions: A rose is a rose is a rose - or not? (2014) (4)
Intravital and high-content multiplex imaging of the immune system (2021) (4)
Antigen presentation. The second class story. (1991) (4)
Response to 'Class II essential for CD4 survival' (2001) (4)
A Multi-scale, Multiomic Atlas of Human Normal and Follicular Lymphoma Lymph Nodes (2022) (4)
Analyzing Inter-Leukocyte Communication and Migration In Vitro: Neutrophils Play an Essential Role in Monocyte Activation During Swarming (2021) (3)
Immunology. Making a molecular match. (1990) (3)
Casting a Wider Net (2003) (3)
Understanding immunity in a tissue‐centric context: Combining novel imaging methods and mathematics to extract new insights into function and dysfunction * (2021) (3)
Role of Suppressor T Cells in Ir Gene Restricted Macrophage-T Cell Interactions in (Responder × Nonresponder)F1 Mice Primed to l-Glutamic Acid60-l-Alanine30-l-Tyrosine10 (GAT) (1978) (2)
Use of molecular techniques for analysis of Ia structure-function relationships. (1985) (2)
Seeing double (1993) (2)
Commensal-driven immune zonation of the liver promotes host defence (2020) (2)
Corrigendum: An interactive web-based application for Comprehensive Analysis of RNAi-screen Data (2016) (2)
A Remembrance of Baruj Benacerraf (AAI '57) 1920–2011 (2011) (2)
Inflammatory ILC2: An IL-25-activated circulating ILC population with a protective role during helminthic infection (2017) (2)
Faculty Opinions recommendation of Therapeutic cell engineering with surface-conjugated synthetic nanoparticles. (2010) (2)
The Cellular Determinants of Adaptive Immunity. (2019) (2)
Fine specificity of antibodies to poly ( Glu 60 Ala 30 Tyr 10 ) produced by hybrid cell lines ( cell hybridization / monoclonal antibodies / idiotype ) (2)
" Exon-shuffling " maps control of antibody-and T-cell-recognition sites to the NH 2-terminal domain of the class II major histocompatibility polypeptide A 8 ( gene transfer / hiistocompatibility antigens / immune response / antigen presentation ) (2003) (2)
William E. Paul, M.D. (1936–2015). (2015) (2)
National Cancer Institute Think-Tank Meeting Report on Proteomic Cartography and Biomarkers at the Single-Cell Level: Interrogation of Premalignant Lesions (2020) (2)
THE ROLE OF MACROPHAGES IN DETERMINING THE BALANCE OF REGULATORY T CELLS SPECIFIC FOR L-GLUTAMIC ACID 60 -L-ALANINE 30 -L-TYROSINE 10 (GAT) (1980) (2)
Double knockin mice show NF-κB trajectories in immune signaling and aging (2022) (2)
Mitochondria play a central role in NLRP3 inflammasome activation (349.1) (2014) (2)
Two hats too many (2002) (1)
Monoclonal antibodies against the antigen receptor on a cloned (1999) (1)
3D-IBEX: Achieving multiplex 3-dimensional imaging for deep phenotyping of cells in tissues (2022) (1)
Human T follicular regulatory cells (Tfr) able to inhibit antibody production are enriched at the lymph node T-B border and rare in germinal centers (2017) (1)
Mesoscale T cell antigen discrimination emerges from intercellular feedback. (2021) (1)
Baruj Benacerraf (1920–2011) (2011) (1)
Lymphoid Tissue Antigen-Bearing Dendritic Cells in the T Cell Vivo : Endotoxin Promotes Accumulation of Visualization of Antigen Presentation In Analysis of Adjuvant Function by Direct (1999) (1)
As data floods in, Germain works overtime to decipher which immunological information matters and how it can be applied to saving lives. Ron Germain: Towards a grand unified theory (2010) (1)
Efficient Immune Cell Genome Engineering with Improved CRISPR Editing Tools (2020) (1)
Allogeneically sensitized cytolytic t lymphocytes specifically lyse tnp derivatized targets h-2 identical to the effectors. Abstr. (1977) (1)
Complementation of H-2 linked genetic defects in the production and function of antigen specific suppressor factor: implications for suppressor cell activation. (1980) (1)
A sustained small increase in NOD1 expression promotes ligand-independent oncogenic activity (2019) (1)
Chapter 22 What Lies Ahead? Scientists Look into Their Crystal Balls (2016) (1)
Abstract 98: Automated cell tracking and interaction analysis in intra-vital two-photon microscopy image data (2010) (1)
Inhibition of Invariant Chain (Ii)-Calnexin Interaction Results in Enhanced Degradation of Ii but Does Not Prevent the Assembly of otpIi Complexes (2003) (1)
Faculty Opinions recommendation of Social network architecture of human immune cells unveiled by quantitative proteomics. (2017) (1)
The role of CD4/L3T4 in T-lymphocyte function. (1987) (1)
THU0374 Use and Validation of Cell Distance Mapping (CDM) in Studying the Pathogenesis of Tubulointerstitial Inflammation in Human Lupus Nephritis (2015) (1)
A SINGLE MONOCLONAL ANTI-la ANTIBODY INHIBITS ANTIGEN-SPECIFIC T CELL SUBREGIONS' PROLIFERATION CONTROLLED BY DISTINCT h GENES MAPPING IN DIFFERENT H-2 I (1982) (1)
SURFACE EXPRESSION OF ONLY yS AND/OR a(3 T CELL RECEPTOR HETERODIMERS BY CELLS WITH FOUR (2003) (1)
The role of idiotype in guiding cellular responses to immunoglobulin idiotypes. (1981) (1)
Author response: IFN-mediated negative feedback supports bacteria class-specific macrophage inflammatory responses (2019) (1)
William E. Paul, MD (1936-2015). (2015) (1)
Niche-Specific Re-Programming of Epigenetic Landscapes Drives Myeloid Cell Diversity in NASH (2020) (1)
Lymphatic Voyage: Communicating 4D Immune Cell Dynamics and Lymph Node Architecture Using WebGL-based Animation and Interactivity (2018) (1)
Tracking the T cell repertoire (2015) (1)
A small sustained increase in NOD1 abundance promotes ligand-independent inflammatory and oncogene transcriptional responses (2020) (1)
Imaging Immunity : Creating a Spatiotemporal Understanding of Host Defense (2016) (1)
Robust, persistent adaptive immune responses to SARS-CoV-2 in the oropharyngeal lymphoid tissue of children (2022) (1)
IBEX: An open and extensible method for high content multiplex imaging of diverse tissues (2021) (1)
Hyperactivated PI3Kδ promotes self and commensal reactivity at the expense of optimal humoral immunity (2018) (1)
IRAK1 attenuates TLR signaling and activates the inflammasome in response to dual-TLR stimulation (2017) (1)
Targeted Proteomics‐Driven Computational Modeling of Macrophage Microbial Sensing Pathways (2018) (1)
Adaptive immune responses to SARS-CoV-2 persist in the pharyngeal lymphoid tissue of children (2022) (1)
Absolute protein quantitation of the mouse macrophage Toll-like receptor and chemotaxis pathways (2022) (1)
II-07 Generation of cell distance mapping plus (CDM+): mapping cognate T cell: dendritic cell interactions and their relationship to cell shape (2016) (0)
Invariant chain regulation of MHC class II function in the secretory and endocytic pathways (1997) (0)
Leading Edge Commentary Healing the NIH-Funded Biomedical Research Enterprise (2015) (0)
Author response: Gut Helicobacter presentation by multiple dendritic cell subsets enables context-specific regulatory T cell generation (2020) (0)
IgE Responses to Synthetic Polypeptide Antigens (1979) (0)
Specific and Nonspecific Antitumor Immunity .MIastocytoma and SL2 Lyymphonma by Draining Lynmph Node Cells From Syngeneic Ttmnior-Bearing DBA 2jJ Mice (2007) (0)
Extensive Restriction Site Polymorphism Surrounding a Single Copy I-Aβ Gene (1983) (0)
Agonistic anti-CD40 converts Tregs into Type 1 effectors within the tumor micro-environment (2022) (0)
Faculty Opinions recommendation of Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation. (2011) (0)
Faculty of 1000 evaluation for Microbial stimulation of different Toll-like receptor signalling pathways induces diverse metabolic programmes in human monocytes. (2018) (0)
Using single cell spatial and transcriptional analysis to understand early host response to RNA virus infections (2021) (0)
Dendritic cells present a tissue-specific autoantigen under steady state and autoimmune conditions in the draining lymph node (2003) (0)
Idiotypic-anti-idiotypic interaction of suppressor t cells modulating immunity to azobenzenearsonate. Abstr. (1980) (0)
Regulation of Suppressor T Cell Function Specific for Ir Controlled Antigens (1978) (0)
Understanding signaling pathways regulating CD4 + T cell effector function (2009) (0)
Medullary Macrophages CD 169 + SCS Macrophages Lymph-Borne Pathogen LS-DCs 1 (2014) (0)
TrendsTalk What Can Immunologists Learn from Systems Approaches ? (2018) (0)
Imaging the immune system redux (2022) (0)
Molecular biology and chemistry of major histocompatibility complex- and Tla-encoded molecules (1985) (0)
CD4+T Cells Are Programmed to Differentiate Before Entry into Division (2016) (0)
ROLE OF SYNGENEIC la' ACCESSORY CELLS IN THE CTL RESPONSES GENERATION OF ALLOSPECIFIC (1982) (0)
The level of an immunological response to a T-dependent antigen is determined by a series of interactions among different subpopulations of effector and regulatory T lymphocytes (2003) (0)
System control of auto-reactive T cells (2017) (0)
33 Visualization and Identification of IL-7 Producing Cells (2007) (0)
Exploiting altered enhancer landscapes to decode pathogenic changes in gene expression of diverse hepatic macrophages (2019) (0)
Double Knock-In Reporter Mice Reveal NF-κB Trajectories in Signaling, Immune Cell Development, and Aging (2022) (0)
AS03-adjuvanted H5N1 vaccine promotes antibody diversity and affinity maturation, NAI titers, cross-clade H5N1 neutralization, but not H1N1 cross-subtype neutralization (2018) (0)
William E. Paul, M.D. (1936–2015), President, The American Association of Immunologists, 1986–1987 (2015) (0)
B-108 Germinal center CD8 T cells can be redirected to eliminate HIV-expressing T follicular helper cells (2014) (0)
Invariant chain promotes egress of poorly expressed, haplotype- mismatched class II major histocompatibility complex AaAf3 dimers from the endoplasmic reticulum/cis-Golgi compartment (protein folding/protein biosynthesis/protein transport/Ia molecules/antigen presentation) (2016) (0)
CRISPR Editing Tools Efficient Immune Cell Genome Engineering with Enhanced (2021) (0)
Faculty Opinions recommendation of The atypical chemokine receptor CCRL1 shapes functional CCL21 gradients in lymph nodes. (2014) (0)
Book Review:Regulatory T Lymphocytes. Benvenuto Pernis, Henry J. Vogel (1981) (0)
Cancer prognosis with shallow tumor RNA sequencing (2020) (0)
The multiple faces of leukocyte interstitial migration (2014) (0)
Involvement of Syngeneic Ia in T Cell Responses to Class I Alloantigens (1983) (0)
Faculty Opinions recommendation of Specific sequences of infectious challenge lead to secondary hemophagocytic lymphohistiocytosis-like disease in mice. (2019) (0)
-bearing I-j+ suppressor t cell factors induce second-order suppres- sor t cells which express anti-idiotypic receptors. (1980) (0)
Blood gene expression-based prediction of lethality after respiratory infection by influenza A virus in mice (2020) (0)
Surface expression and function of class ii mhc molecules in the presence and absence of invariant chain (1987) (0)
Variant Ligands, Altered T Cell Receptor Signaling, Hierarchical Response Thresholds, and CD4 + Effector Responses (2002) (0)
Humoral responses require a multi-stage T:B lymphocyte interaction process (99.5) (2010) (0)
Individual TCR Signaling Events Ligands : Relationship to the Quality of Down-Modulation by Peptide : MHC Molecule Serial TCR Engagement and (1999) (0)
IL-1 uses distinct mechanisms to enhance CD8+ T cell expansion and differentiation. (2016) (0)
Integration and Iteration: Using Advanced, High-Content Imaging and Single-Cell Gene Expression Analysis to Uncover Unique Aspects of Follicular Lymphoma Biology (2020) (0)
Induced negative regulation decodes PAMP quality and quantity to generate bacteria-specific inflammatory responses (2017) (0)
TCR strength of signal is upstream of and dominates over cytokine effects in controlling CD4+ T cell polarization in vivo (IRC2P.449) (2014) (0)
Immuno imaging (SY4-3) Chairpersons: Takashi Saito, Susan Pierce (2010) (0)
EngagementCD28 on Selection Events Induced by TCR Influence of Cosignaling by Integrins and Selection: Developmental Changes in the Opening a Window on Thymic Positive (2000) (0)
and Effector Function in the Lung T Cell Dynamic Behavior + Reflected in CD4 Abundance of Presented Antigen Are Pathogen-Related Differences in the (2014) (0)
CD4+ T-cell cytokine production within airway mucosal DC-T-cell clusters drives the local recruitment of myeloid effector cells in response to house dust mite allergen. (2016) (0)
Idiotypic analysis of monoclonal antibodies to p 6 ly ( Glu 60 Ala 30 Tyr 10 ) ( hybridoma antibody / idiotype / antibody diversity ) (0)
Recent Progress Using Systems Biology to Better Understand Molecular Mechanisms of Immunity (2013) (0)
Single Cell Analysis Reveals Regulated Hierarchical T Cell Antigen Receptor Signaling Thresholds and Intraclonal Heterogeneity for Individual Cytokine Responses of CD4 (cid:49) T Cells (1997) (0)
Are there Unique I Region-Controlled Determinants on T-Cells? (2019) (0)
Abstract 70: Mechanisms of tumor dormancy induction mediated by abrogation of myeloid tgfβ signaling (2023) (0)
Faculty Opinions recommendation of Proteomics of SARS-CoV-2-infected host cells reveals therapy targets. (2020) (0)
Multiplex imaging to reveal the dynamics of MAVS-mediated control of Ebola virus replication in tissues. (2022) (0)
Allele-specific control of la molecu (2016) (0)
Lentivirus-mediated Conditional Gene Expression (2021) (0)
Abstract 1527: Hijacking Suppression: Anti-CD40 Converts Regulatory T Cells Into Type I Effectors (2023) (0)
A modest change in regulation of NOD1 expression has a major impact on inflammation and gastric cancer (2018) (0)
574 Multiplex microscopy reveals unique spatiotemporal effects of cancer immunotherapies (2021) (0)
Distinct spatial localization of resident dendritic cell subsets in lymph nodes (100.30) (2011) (0)
The role of lymphoid micro-architecture in dendritic cell-mediated antigen capture and initiation of cellular adaptive immunity (P5200) (2013) (0)
Intravital 2-Photon Microscopy of Dendritic Cell Extension Sampling Pathogen Bacteria Into the Small Bowel Lumen (2006) (0)
3D visualization of sex differences in the immune response to influenza infection in the mouse lung (2017) (0)
Mitogenic activation of EL-4 cells does not require surface Thy-1 expression. (1988) (0)
Abstract A62: Directly visualizing interactions between lung microbiota, tissue-resident immune cells and tumor cells in a genetically engineered lung adenocarcinoma mouse model (2020) (0)
Response (2001) (0)
Open questions: A rose is a rose is a rose - or not? (2014) (0)
Intubation-free in vivo imaging of the tracheal mucosa using two-photon microscopy (2017) (0)
Faculty Opinions recommendation of Antigen presentation profiling reveals recognition of lymphoma immunoglobulin neoantigens. (2018) (0)
Obituary: Charles A. Janeway Jr (1943–2003) (2003) (0)
Immunological techniques. (1989) (0)
How can systems approaches help us understand and treat infectious disease? (2022) (0)
Increased immune activation during chronic SIV infection drives the TFH dynamics. (105.33) (2012) (0)
Faculty Opinions recommendation of A platelet-mediated system for shuttling blood-borne bacteria to CD8α+ dendritic cells depends on glycoprotein GPIb and complement C3. (2011) (0)
Workshop Summary: Transfection of MHC Genes (1986) (0)
"Antigen processing and presentation". (1992) (0)
Modeling collective cell behavior in cancer: Perspectives from an interdisciplinary conversation. (2023) (0)
Presenting Cell Type Requirements for Ligand Quality and of Thymocyte Positive Selection Has Distinct TCR Signaling for Initiation and Completion (2000) (0)
Author Correction: Commensal-driven immune zonation of the liver promotes host defence (2022) (0)
Structural and functional analysis of T cell responses to Ia antigens (1984) (0)
High-dimensional cell-level analysis of tissues with Ce3D multiplex volume imaging (2019) (0)
PL2-1. Bottom-up and Top-Down Systems Biology Approaches to Understanding Immunity (2011) (0)
Quantifying in situ adaptive immune cell cognate interactions in humans (2019) (0)
Author Correction: Commensal-driven immune zonation of the liver promotes host defence (2021) (0)
Immune regulation by glucocorticoids can be linked to cell-lineage-specific transcriptional responses (2018) (0)
Immunodominant ctl epitope of hiv 1 envelope protein the relationship between viral mutation and ctl specificity (1990) (0)
Efficient Immune Cell Genome Engineering with Enhanced CRISPR Editing Tools (2021) (0)
William E. Paul (1936–2015) (2015) (0)
Dominant-activating Gαi2 mutations cause human immunodeficiency and autoimmunity by causing defective leukocyte migration and altered T cell activation (2017) (0)
Absolute protein quantitation of the mouse macrophage Toll-like receptor and chemotaxis pathways (2022) (0)
Correction for Gaiser et al., Cancer-associated epithelial cell adhesion molecule (EpCAM; CD326) enables epidermal Langerhans cell motility and migration in vivo (2016) (0)
Abstract NG04: Agonistic anti-CD40 converts regulatory T cells in to Type 1 effector cells within the tumor microenvironment (2023) (0)
Faculty Opinions recommendation of Selective autophagy of the adaptor TRIF regulates innate inflammatory signaling. (2018) (0)
Dynamic intravital imaging of immune cell migration, interaction, and effector function (2009) (0)
ANTIGEN-SPECIFIC T CELL-MEDIATED SUPPRESSION V. H-2-1inked Genetic Control of Distinct Antigen-specific Defects in the Production and Activity of L-Glutamic AcidS°-L-Tyrosine 5° Suppressor Factor* (2003) (0)
9 – Ia Structure and Immune Recognition (1988) (0)
Combining gene expression data from inflamed tissue and machine learning for blood biomarker discovery (2017) (0)
Regulation of TCR-induced stop signal and T cell-effector function in peripheral tissue through PD-L1-PD-1 signaling (2013) (0)
Novel tissue clearing method for preservation of morphology, fluorescence and epitope integrity permits quantitative cellular analysis in intact organs (2016) (0)
Agonistic-CD40 therapy alters the spatial localization of immune cells in the tumor microenvironment: implications for therapeutic responsiveness (2020) (0)
Regulatory T cells (PP-045) (2010) (0)
Sequential activity of innate and adaptive lymphocytes supports non-inflammatory gut microbial commensalism (2017) (0)
Faculty Opinions recommendation of Integration of multi-omics data and deep phenotyping enables prediction of cytokine responses. (2019) (0)
TD-03 Convolutional neural networks identify in situ adaptive immune cell architectures in human lupus (2018) (0)
Peptide Binding, Conformational Changes, And Intra-cellular Transport In The Mhc Class I And Class Ii Presentation Pathways (1993) (0)
NK-DC crosstalk controls the autopathogenic Th17 response and suppresses uveitis through an innate IFN-γ/IL-27 axis (2015) (0)
Dendritic cell subset positioning governs clonal diversity and magnitude of the CD8 T cell response (2016) (0)

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