Ronen Marmorstein

Ronen Marmorstein's AcademicInfluence.com Rankings

Ronen Marmorstein

Biology

#9346

World Rank

#12541

Historical Rank

Molecular Biology

#1268

World Rank

#1295

Historical Rank

Biochemistry

#1418

World Rank

#1542

Historical Rank

biology Degrees

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Biology

Ronen Marmorstein's Degrees

PhD Biochemistry University of Pennsylvania
Bachelors Chemistry University of California, Berkeley

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Ronen Marmorstein's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate (2009) (881)
p53 Sites Acetylated In Vitro by PCAF and p300 Are Acetylated In Vivo in Response to DNA Damage (1999) (816)
Acetylation of the p53 DNA-binding domain regulates apoptosis induction. (2006) (727)
Crystal structure of trp represser/operator complex at atomic resolution (1988) (653)
DNA recognition by GAL4: structure of a protein-DNA complex (1992) (633)
Phosphorylation of serine 10 in histone H3 is functionally linked in vitro and in vivo to Gcn5-mediated acetylation at lysine 14. (2000) (587)
Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor. (2010) (553)
Autophagy mediates degradation of nuclear lamina (2015) (450)
Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours (2017) (408)
The structural basis of protein acetylation by the p300/CBP transcriptional coactivator (2008) (397)
Histone acetyltransferases: function, structure, and catalysis. (2001) (381)
Writers and readers of histone acetylation: structure, mechanism, and inhibition. (2014) (369)
Histone modifying enzymes: structures, mechanisms, and specificities. (2009) (301)
Chemistry of acetyl transfer by histone modifying enzymes: structure, mechanism and implications for effector design (2007) (254)
Structure of Tetrahymena GCN5 bound to coenzyme A and a histone H3 peptide (1999) (252)
A tight junction-associated Merlin-angiomotin complex mediates Merlin's regulation of mitogenic signaling and tumor suppressive functions. (2011) (248)
Structure of the Human Papillomavirus E7 Oncoprotein and Its Mechanism for Inactivation of the Retinoblastoma Tumor Suppressor* (2006) (219)
Catalytic Mechanism and Function of Invariant Glutamic Acid 173 from the Histone Acetyltransferase GCN5 Transcriptional Coactivator* (1999) (217)
Protein modules that manipulate histone tails for chromatin regulation (2001) (203)
Maintenance of low histone ubiquitylation by Ubp10 correlates with telomere-proximal Sir2 association and gene silencing. (2005) (198)
Structurally sophisticated octahedral metal complexes as highly selective protein kinase inhibitors. (2011) (194)
Structural basis for DNA recognition by FoxO1 and its regulation by posttranslational modification. (2008) (189)
Structural basis for sirtuin function: what we know and what we don't. (2010) (189)
Targeting large kinase active site with rigid, bulky octahedral ruthenium complexes. (2008) (186)
Structure and function of histone acetyltransferases (2001) (178)
Inhibition of Eukaryotic DNA Replication by Geminin Binding to Cdt1 (2000) (176)
Crystal structure and mechanism of histone acetylation of the yeast GCN5 transcriptional coactivator. (1999) (174)
Structure of a human ASF1a–HIRA complex and insights into specificity of histone chaperone complex assembly (2006) (173)
Concurrent MEK2 mutation and BRAF amplification confer resistance to BRAF and MEK inhibitors in melanoma. (2013) (173)
Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD(+)-dependent Sir2 histone/protein deacetylases. (2004) (172)
Structure and chemistry of the p300/CBP and Rtt109 histone acetyltransferases: implications for histone acetyltransferase evolution and function. (2008) (167)
Structure of histone acetyltransferases. (2001) (164)
Human immunodeficiency virus type 1 Tat protein inhibits the SIRT1 deacetylase and induces T cell hyperactivation. (2008) (163)
The catalytic mechanism of the ESA1 histone acetyltransferase involves a self-acetylated intermediate (2002) (162)
Crystal structure of yeast Esa1 suggests a unified mechanism for catalysis and substrate binding by histone acetyltransferases. (2000) (161)
Crystal structure of a PPR1-DNA complex: DNA recognition by proteins containing a Zn2Cys6 binuclear cluster. (1994) (160)
Structural basis for histone and phosphohistone binding by the GCN5 histone acetyltransferase. (2003) (153)
Crystal structure of the retinoblastoma tumor suppressor protein bound to E2F and the molecular basis of its regulation (2003) (153)
Crystal structure of the histone acetyltransferase domain of the human PCAF transcriptional regulator bound to coenzyme A (1999) (150)
Structure of the p53 Core Domain Dimer Bound to DNA*♦ (2006) (134)
A Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles. (2017) (131)
Structure and substrate binding properties of cobB, a Sir2 homolog protein deacetylase from Escherichia coli. (2004) (131)
A mechanism-based inactivator for histone demethylase LSD1. (2006) (131)
Molecular Basis for Amino-Terminal Acetylation by the Heterodimeric NatA Complex (2013) (129)
Structure and Mechanism of Lysine-specific Demethylase Enzymes* (2007) (124)
7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBER (2006) (123)
Characterization of histone acylations links chromatin modifications with metabolism (2017) (122)
The microtubule-associated tau protein has intrinsic acetyltransferase activity (2013) (121)
Fungal Rtt109 histone acetyltransferase is an unexpected structural homolog of metazoan p300/CBP (2008) (121)
PPT1 Promotes Tumor Growth and Is the Molecular Target of Chloroquine Derivatives in Cancer. (2018) (118)
MYST protein acetyltransferase activity requires active site lysine autoacetylation (2012) (118)
Solution structure of the DNA-binding domain of Cd2-GAL4 from S. cerevisiae (1992) (116)
Structure and activity of enzymes that remove histone modifications. (2005) (115)
Crystal structure of trp represser/operator complex at atomic resolution (1988) (111)
Structural Basis for Sirtuin Activity and Inhibition* (2012) (111)
DNA sequence preferences of GAL4 and PPR1: how a subset of Zn2 Cys6 binuclear cluster proteins recognizes DNA (1996) (111)
Structures of SAP-1 bound to DNA targets from the E74 and c-fos promoters: insights into DNA sequence discrimination by Ets proteins. (1998) (110)
Human UBN1 Is an Ortholog of Yeast Hpc2p and Has an Essential Role in the HIRA/ASF1a Chromatin-Remodeling Pathway in Senescent Cells (2008) (108)
Structural Basis for Ubiquitin Recognition by the Otu1 Ovarian Tumor Domain Protein* (2008) (108)
Structure of the yeast Hst2 protein deacetylase in ternary complex with 2'-O-acetyl ADP ribose and histone peptide. (2003) (103)
Structure and autoregulation of the yeast Hst2 homolog of Sir2 (2003) (103)
Structure of the GCN5 histone acetyltransferase bound to a bisubstrate inhibitor (2002) (102)
Structure of the Elk-1–DNA complex reveals how DNA-distal residues affect ETS domain recognition of DNA (2000) (102)
FRAX597, a Small Molecule Inhibitor of the p21-activated Kinases, Inhibits Tumorigenesis of Neurofibromatosis Type 2 (NF2)-associated Schwannomas* (2013) (101)
Ubinuclein-1 confers histone H3.3-specific-binding by the HIRA histone chaperone complex (2015) (100)
Site-specific introduction of an acetyl-lysine mimic into peptides and proteins by cysteine alkylation. (2010) (99)
Structure and function of the SWIRM domain, a conserved protein module found in chromatin regulatory complexes (2006) (99)
14-3-3 Interaction with Histone H3 Involves a Dual Modification Pattern of Phosphoacetylation (2008) (99)
Structure-function studies of the BTB/POZ transcriptional repression domain from the promyelocytic leukemia zinc finger oncoprotein. (1999) (98)
Structure of histone deacetylases: insights into substrate recognition and catalysis. (2001) (98)
Structure and function of bromodomains in chromatin-regulating complexes. (2001) (96)
Application of a fluorescent histone acetyltransferase assay to probe the substrate specificity of the human p300/CBP-associated factor. (2000) (95)
Structure of SET domain proteins: a new twist on histone methylation. (2003) (92)
Biochemical and cellular analysis of Ogden syndrome reveals downstream Nt-acetylation defects (2014) (91)
Crystal Structure of the Mouse p53 Core DNA-binding Domain at 2.7 Å Resolution* (2001) (88)
The art of filling protein pockets efficiently with octahedral metal complexes. (2012) (87)
Crystal Structure of the Stress-Inducible Human Heat Shock Protein 70 Substrate-Binding Domain in Complex with Peptide Substrate (2014) (87)
Structural basis for dimerization in DNA recognition by Gal4. (2008) (86)
Structure of the retinoblastoma protein bound to adenovirus E1A reveals the molecular basis for viral oncoprotein inactivation of a tumor suppressor. (2007) (86)
Crystal structure of a PUT3–DNA complex reveals a novel mechanism for DMA recognition by a protein containing a Zn2Cys6 binuclear cluster (1997) (85)
Structure of a Ternary Naa50p (NAT5/SAN) N-terminal Acetyltransferase Complex Reveals the Molecular Basis for Substrate-specific Acetylation* (2011) (84)
Human CABIN1 Is a Functional Member of the Human HIRA/UBN1/ASF1a Histone H3.3 Chaperone Complex (2011) (83)
Acridine derivatives activate p53 and induce tumor cell death through bax (2005) (82)
Histone acetyltransferases: Rising ancient counterparts to protein kinases (2013) (81)
Molecular basis for Gcn5/PCAF histone acetyltransferase selectivity for histone and nonhistone substrates. (2003) (80)
Structure and chemistry of the Sir2 family of NAD+-dependent histone/protein deactylases. (2004) (79)
Crystal structure of the CDK4/6 inhibitory protein p18INK4c provides insights into ankyrin-like repeat structure/function and tumor-derived p16INK4 mutations (1998) (79)
Structure of a HAP1–DNA complex reveals dramatically asymmetric DNA binding by a homodimeric protein (1999) (79)
Toward the development of a potent and selective organoruthenium mammalian sterile 20 kinase inhibitor. (2009) (73)
Crystal Structure of a p53 Core Tetramer Bound to DNA (2008) (72)
Crystal structure of a ternary SAP-1/SRF/c-fos SRE DNA complex. (2001) (72)
Inhibition of Epstein-Barr Virus OriP Function by Tankyrase, a Telomere-Associated Poly-ADP Ribose Polymerase That Binds and Modifies EBNA1 (2005) (71)
The crystal structure of BRAF in complex with an organoruthenium inhibitor reveals a mechanism for inhibition of an active form of BRAF kinase. (2009) (70)
Structure of the α-tubulin acetyltransferase, αTAT1, and implications for tubulin-specific acetylation (2012) (69)
Crystal structure and functional interpretation of the erythrocyte spectrin tetramerization domain complex. (2010) (69)
Structure and dimerization of the kinase domain from yeast Snf1, a member of the Snf1/AMPK protein family. (2006) (69)
Molecular Basis for Oligomeric-DNA Binding and Episome Maintenance by KSHV LANA (2013) (65)
Overexpression, Purification, Characterization, and Crystallization of the BTB/POZ Domain from the PLZF Oncoprotein* (1997) (63)
Identification of Host-Chromosome Binding Sites and Candidate Gene Targets for Kaposi's Sarcoma-Associated Herpesvirus LANA (2012) (63)
Structural basis for nicotinamide inhibition and base exchange in Sir2 enzymes. (2007) (62)
Structure of a Sir2 Substrate, Alba, Reveals a Mechanism for Deacetylation-induced Enhancement of DNA Binding* (2003) (62)
Identification of a novel family of BRAF(V600E) inhibitors. (2012) (62)
The structural basis for the interaction between L-tryptophan and the Escherichia coli trp aporepressor. (1987) (62)
Structure and mechanism of non‐histone protein acetyltransferase enzymes (2013) (61)
Architectural Organization of the Metabolic Regulatory Enzyme Ghrelin O-Acyltransferase* (2013) (61)
Structure of Vps75 and implications for histone chaperone function (2008) (60)
The molecular basis for histone H4- and H2A-specific amino-terminal acetylation by NatD. (2015) (59)
SIRT1 Contains N- and C-terminal Regions That Potentiate Deacetylase Activity* (2011) (59)
Structure of the p300 Histone Acetyltransferase Bound to Acetyl-Coenzyme A and Its Analogues (2014) (54)
The MEK/ERK Network as a Therapeutic Target in Human Cancer (2020) (54)
Structure of the Rtt109-AcCoA/Vps75 complex and implications for chaperone-mediated histone acetylation. (2011) (54)
Nuclear export modulates the cytoplasmic Sir2 homologue Hst2 (2006) (53)
The Human Monocytic Leukemia Zinc Finger Histone Acetyltransferase Domain Contains DNA-binding Activity Implicated in Chromatin Targeting* (2007) (52)
Salicylate, diflunisal and their metabolites inhibit CBP/p300 and exhibit anticancer activity (2016) (52)
Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pK a Polar Moiety. (2015) (52)
Coexpression of proteins in bacteria using T7-based expression plasmids: expression of heteromeric cell-cycle and transcriptional regulatory complexes. (2000) (51)
Structural Basis for the Inhibition of HSP70 and DnaK Chaperones by Small-Molecule Targeting of a C-Terminal Allosteric Pocket (2014) (50)
Structural determinants and cellular environment define processed actin as the sole substrate of the N-terminal acetyltransferase NAA80 (2018) (50)
Structure-based design of an organoruthenium phosphatidyl-inositol-3-kinase inhibitor reveals a switch governing lipid kinase potency and selectivity. (2008) (50)
Biochemical analysis of MST1 kinase: elucidation of a C-terminal regulatory region. (2008) (49)
Multiple roles for acetylation in the interaction of p300 HAT with ATF-2. (2007) (48)
Oligomerization properties of the viral oncoproteins adenovirus E1A and human papillomavirus E7 and their complexes with the retinoblastoma protein. (2000) (47)
Structure of Human NatA and Its Regulation by the Huntingtin Interacting Protein HYPK. (2018) (46)
The N-terminal Acetyltransferase Naa10/ARD1 Does Not Acetylate Lysine Residues* (2016) (45)
Discovery of Spiro Oxazolidinediones as Selective, Orally Bioavailable Inhibitors of p300/CBP Histone Acetyltransferases (2017) (44)
Stereochemical effects of L-tryptophan and its analogues on trp repressor's affinity for operator-DNA. (1989) (44)
Identification and Characterization of Small Molecule Human Papillomavirus E6 Inhibitors (2014) (43)
Molecular Basis for Histone Acetyltransferase Regulation by Binding Partners, Associated Domains, and Autoacetylation. (2016) (41)
Nonenzymatic Protein Acetylation Detected by NAPPA Protein Arrays. (2015) (41)
Implications for the evolution of eukaryotic amino-terminal acetyltransferase (NAT) enzymes from the structure of an archaeal ortholog (2013) (40)
Crystal Structure of the Golgi-Associated Human Nα-Acetyltransferase 60 Reveals the Molecular Determinants for Substrate-Specific Acetylation. (2016) (39)
Erratum: Crystal structure of trp represser/operator complex at atomic resolution (Nature (1988) 335 (321-329)) (1988) (39)
Viral Reprogramming of the Daxx Histone H3.3 Chaperone during Early Epstein-Barr Virus Infection (2014) (38)
Development of small-molecule inhibitors of the group I p21-activated kinases, emerging therapeutic targets in cancer. (2010) (38)
Identification of BRAF inhibitors through in silico screening. (2008) (36)
DAXX represents a new type of protein-folding enabler (2021) (35)
Phenotypic and biochemical analysis of an international cohort of individuals with variants in NAA10 and NAA15. (2019) (35)
Functional activity of the H3.3 histone chaperone complex HIRA requires trimerization of the HIRA subunit (2018) (33)
A Molecular Prospective for HIRA Complex Assembly and H3.3-Specific Histone Chaperone Function. (2017) (31)
Menin and Daxx Interact to Suppress Neuroendocrine Tumors through Epigenetic Control of the Membrane Metallo-Endopeptidase. (2017) (31)
Identification and characterization of novel sirtuin inhibitor scaffolds. (2009) (30)
Protein N-Terminal Acetylation: Structural Basis, Mechanism, Versatility, and Regulation. (2020) (29)
Probing the interaction between NatA and the ribosome for co-translational protein acetylation (2017) (28)
Fungal Rtt109 histone acetyltransferase is an unexpected structural homolog of metazoan p300/CBP (2008) (28)
Structure and Mechanism of Acetylation by the N-Terminal Dual Enzyme NatA/Naa50 Complex. (2019) (28)
Identification and characterization of small molecule antagonists of pRb inactivation by viral oncoproteins. (2012) (28)
Identification of an ubinuclein 1 region required for stability and function of the human HIRA/UBN1/CABIN1/ASF1a histone H3.3 chaperone complex. (2012) (27)
Structural Basis for Interaction between the Ubp3 Deubiquitinating Enzyme and Its Bre5 Cofactor* (2005) (27)
Modulation of DNA-binding domains for sequence-specific DNA recognition. (2003) (26)
The structurally disordered KRAB repression domain is incorporated into a protease resistant core upon binding to KAP-1-RBCC domain. (2007) (26)
Catalytic mechanism of histone acetyltransferase p300: from the proton transfer to acetylation reaction. (2014) (26)
Chaperone-mediated acetylation of histones by Rtt109 identified by quantitative proteomics. (2013) (25)
Structure and Biochemical Characterization of Protein Acetyltransferase from Sulfolobus solfataricus* (2009) (25)
Biochemical and structural characterization of recombinant histone acetyltransferase proteins. (2004) (24)
Molecular basis for bre5 cofactor recognition by the ubp3 deubiquitylating enzyme. (2007) (24)
Molecular basis for N-terminal acetylation by human NatE and its modulation by HYPK (2020) (24)
Structure of HAP1-18–DNA implicates direct allosteric effect of protein–DNA interactions on transcriptional activation (1999) (24)
An alkaline phosphatase protection assay to investigate trp repressor/operator interactions. (1991) (23)
Dissecting the Molecular Roles of Histone Chaperones in Histone Acetylation by Type B Histone Acetyltransferases (HAT-B)* (2015) (21)
Crystals of the trp repressor-operator complex suitable for X-ray diffraction analysis. (1987) (21)
Structural and chemical basis of histone acetylation. (2004) (20)
FRAX 597 , a Small Molecule Inhibitor of the p 21-activated Kinases , Inhibits Tumorigenesis of Neurofibromatosis Type 2 ( NF 2 )-associated Schwannomas * (2013) (19)
High-resolution structure of the p53 core domain: implications for binding small-molecule stabilizing compounds. (2006) (19)
When viral oncoprotein meets tumor suppressor: a structural view. (2006) (19)
Chemically Linked Vemurafenib Inhibitors Promote an Inactive BRAFV600E Conformation. (2016) (18)
Development of a novel class of B-Raf(V600E)-selective inhibitors through virtual screening and hierarchical hit optimization. (2012) (18)
Structure of a Leu3-DNA complex: recognition of everted CGG half-sites by a Zn2Cys6 binuclear cluster protein. (2006) (18)
Ankyrin for methylated lysines (2008) (18)
Mechanism of BRAF Activation through Biochemical Characterization of the Recombinant Full‐Length Protein (2018) (16)
Molecular basis for acetyl-CoA production by ATP-citrate lyase (2019) (16)
ATP-citrate lyase multimerization is required for coenzyme-A substrate binding and catalysis (2019) (16)
Development of Organometallic S6K1 Inhibitors (2014) (15)
Conserved Lysine Acetylation within the Microtubule-Binding Domain Regulates MAP2/Tau Family Members (2016) (15)
Structural and Functional Role of Acetyltransferase hMOF K274 Autoacetylation* (2016) (14)
Molecular Basis for Cohesin Acetylation by Establishment of Sister Chromatid Cohesion N-Acetyltransferase ESCO1* (2016) (14)
Different regions of the HPV-E7 and Ad-E1A viral oncoproteins bind competitively but through distinct mechanisms to the CH1 transactivation domain of p300. (2012) (14)
Crystal structure and mechanism of histone acetylation of the yeast GCN 5 transcriptional coactivator (1999) (13)
Crystallization of Macromolecules (2003) (13)
Red Wine, Toast of the Town (Again) (2013) (13)
Drugging the “Undruggable” MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers (2021) (13)
Structural Basis for MARK1 Kinase Autoinhibition by Its KA1 Domain. (2018) (12)
The scaffolding protein JADE1 physically links the acetyltransferase subunit HBO1 with its histone H3–H4 substrate (2018) (12)
Actin's N‐terminal acetyltransferase uncovered (2018) (11)
Intramolecular autoinhibition of checkpoint kinase 1 is mediated by conserved basic motifs of the C-terminal kinase–associated 1 domain (2017) (11)
Molecular basis for chromatin assembly and modification by multiprotein complexes (2018) (11)
Structure-based Design of p18INK4cProteins with Increased Thermodynamic Stability and Cell Cycle Inhibitory Activity* (2002) (11)
Molecular basis for N-terminal alpha-synuclein acetylation by human NatB (2020) (11)
Phenotypic and biochemical analysis of an international cohort of individuals with variants in NAA10 and NAA15. (2020) (10)
Rap1‐mediated nucleosome displacement can regulate gene expression in senescent cells without impacting the pace of senescence (2019) (10)
The copper chaperone CCS facilitates copper binding to MEK1/2 to promote kinase activation. (2021) (10)
P-donor ligand containing ruthenium half-sandwich complexes as protein kinase inhibitors (2011) (10)
STRUCTURES OF SAP-1 BOUND TO DNA SEQUENCES FROM THE E74 AND C-FOS PROMOTERS PROVIDE INSIGHTS INTO HOW ETS PROTEINS DISCRIMINATE BETWEEN RELATED DNA TARGETS (1998) (9)
Insights into structure and function of GCN5/PCAF and yEsa 1 histone acetyltransferase domains:. (2003) (9)
Structure of HAP1-PC7 bound to DNA: implications for DNA recognition and allosteric effects of DNA-binding on transcriptional activation. (2000) (9)
Opposing Functions of the N-terminal Acetyltransferases Naa50 and NatA in Sister-chromatid Cohesion* (2016) (8)
Dehydrogenases, NAD, and transcription--what's the connection? (2002) (8)
The HIRA histone chaperone complex subunit UBN1 harbors H3/H4- and DNA-binding activity (2019) (7)
Author Correction: Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours (2018) (7)
6-Nitro-L-tryptophan: a novel spectroscopic probe of trp aporepressor and human serum albumin. (1988) (7)
Specificity and Versatility of Substrate Binding Sites in Four Catalytic Domains of Human N-Terminal Acetyltransferases (2012) (6)
Discovery of Spirohydantoins as Selective, Orally Bioavailable Inhibitors of p300/CBP Histone Acetyltransferases. (2021) (6)
N-(7-Cyano-6-(4-fluoro-3-(2-(3-(trifluoromethyl)phenyl)acetamido)phenoxy)benzo[d]thiazol-2-yl)cyclopropanecarboxamide (TAK632) Promotes Inhibition of BRAF through the Induction of Inhibited Dimers. (2018) (6)
CTCF-Induced Circular DNA Complexes Observed by Atomic Force Microscopy. (2018) (6)
Generation and characterization of monoclonal antibodies against the E6 and E7 oncoproteins of HPV. (2001) (6)
Naa12 compensates for Naa10 in mice in the amino-terminal acetylation pathway (2020) (5)
N-alpha-acetylation of Huntingtin protein increases its propensity to aggregate (2021) (5)
Co-expression of proteins in E. coli using dual expression vectors. (2003) (5)
Remodelin Is a Cryptic Assay Interference Chemotype That Does Not Inhibit NAT10-Dependent Cytidine Acetylation. (2020) (5)
Chapter 3:Structural Basis for Sequence-specific DNA Recognition by Transcription Factors and their Complexes (2008) (4)
Structure and Mechanism of the trp Repressor/Operator System (1989) (4)
Identification and synthesis of N-(thiophen-2-yl) benzamide derivatives as BRAF(V600E) inhibitors. (2013) (4)
Molecular mechanism of N-terminal acetylation by the ternary NatC complex (2021) (4)
Structure of the Sir2 Family of NAD+-Dependent Histone/Protein Deacetylases (2006) (4)
Transcription Initiation at Its Most Basic Level (2003) (4)
Identi fi cation and Characterization of Small Molecule Human Papillomavirus E 6 Inhibitors (2014) (3)
In Vitro Activity Assays for MYST Histone Acetyltransferases and Adaptation for High-Throughput Inhibitor Screening. (2016) (3)
Author Correction: Molecular basis for acetyl-CoA production by ATP-citrate lyase (2019) (3)
Structure of the alpha-tubulin acetyltransferase, alpha-TAT1 (2012) (3)
CRYSTAL STRUCTURE OF TETRAHYMENA GCN5 WITH BOUND COENZYME A AND HISTONE H3 PEPTIDE (1999) (3)
Identification and Characterization of a B-Raf Kinase Alpha Helix Critical for the Activity of MEK Kinase in MAPK Signaling (2020) (2)
Erratum: CTCF binding site sequence differences are associated with unique regulatory and functional trends during embryonic stem cell differentiation (Nucleic Acids Research (2014) 42 (774-789) DOI:10.1093/nar/gkt910) (2014) (2)
Expanding the Phenotypic spectrum of Ogden syndrome (NAA10-related neurodevelopmental syndrome) and NAA15-related neurodevelopmental syndrome (2022) (2)
Structural and molecular determinants of CCS-mediated copper activation of MEK1/2 (2020) (2)
Biochemical and structural analysis of N-terminal acetyltransferases. (2019) (2)
Novel Bisubstrate Inhibitors for Protein N-Terminal Acetyltransferase D. (2021) (2)
Allosteric role of a structural NADP+ molecule in glucose-6-phosphate dehydrogenase activity (2022) (2)
Structural biology: Hypoxia response becomes crystal clear (2015) (2)
The heme-regulated inhibitor kinase requires dimerization for heme-sensing activity (2022) (1)
Unfolding Mechanisms and Conformational Stability of the Dimeric Endophilin N-BAR Domain (2021) (1)
Crystal structure of p300 histone acetyltransferase domain in complex with a bisubstrate inhibitor, Lys-CoA (2008) (1)
STRUCTURE OF A HAP1-18/DNA COMPLEX REVEALS THAT PROTEIN/DNA INTERACTIONS CAN HAVE DIRECT ALLOSTERIC EFFECTS ON TRANSCRIPTIONAL ACTIVATION (1999) (1)
Novel bisubstrate inhibitors for protein N-terminal acetyltransferase D (2021) (1)
Crystallization of Macromolecules (2003) (1)
Molecular basis for acetyl-CoA production by ATP-citrate lyase (2019) (1)
Enzymes of Epigenetics (2016) (1)
Anticipating drug resistance in the MAP kinase pathway (2010) (1)
Crystal structure of the mouse p53 core domain at 1.55 A (2006) (0)
Tyrosine phosphorylation is critical for ACLY activity in lipid metabolism and cancer (2020) (0)
Tyrosine phosphorylation of ACLY regulates lipid metabolism and oncogenesis in ALK positive Anaplastic Large Cell Lymphoma (2020) (0)
Decameric ring structure of KSHV (HHV-8) latency-associated nuclear antigen (LANA) DNA binding domain (2013) (0)
Cryo-EM structure of S. Pombe NatC complex with a Bisubstrate inhibitor and inositol hexaphosphate (2021) (0)
Cryo-EM structure of human NatB complex (2020) (0)
Expanding the phenotypic spectrum of NAA10-related neurodevelopmental syndrome and NAA15-related neurodevelopmental syndrome. (2023) (0)
Non-catalytic regulation of 18S rRNA methyltransferase DIMT1 in acute myeloid leukemia (2023) (0)
Archaeal amino-terminal acetyltransferase (NAT) bound to acetyl coenzyme A (2013) (0)
CRYSTAL STRUCTURE OF P18-INK4C(INK6) (1998) (0)
TITLE : Structure-Based Design of Molecules to Reactivate Tumor Derived p 53 Mutations (0)
Crystal Structure of Tetrahymena GCN5 with Bound Coenzyme A and a Phosphorylated, 19-residue Histone H3 peptide (2003) (0)
Structure-Based Design of CSDK4-Specific Inhibitors (2003) (0)
Structure of ATP citrate lyase with CoA in a partially open conformation (2019) (0)
Crystal Structure of FoxO1 DBD Bound to DBE1 DNA (2008) (0)
Crystal structure of yeast Esa1 histone acetyltransferase E338Q mutant complexed with acetyl coenzyme A (2002) (0)
Crystal structure of KA1-autoinhibited MARK1 kinase (2018) (0)
Functional activity of the H3.3 histone chaperone complex HIRA requires trimerization of the HIRA subunit (2018) (0)
Crystal structure of p300 histone acetyltransferase domain in complex with Acetyl-Coenzyme A (2014) (0)
Mouse p53 core domain soaked with 2-propanol (2006) (0)
Structure of death-associated protein Kinase 1 (dapk1) in complex with a ruthenium octasporine ligand (OSV) (2011) (0)
Crystal Structure of the HAT domain of the human MOZ protein (2007) (0)
Link between histone deubiquitination and protection of telomeres (2005) (0)
A Novel Continuous Assay for the Mechanistic Characterization of Histone Deacetylases and Homologues Using a Small Molecule Fluorescent Substrate (2001) (0)
Thetrprepressor/operator system: the crystallography of ligand-activated genetic regulation (1987) (0)
Crystal Structure of the Vps75 Histone Chaperone (2008) (0)
STRUCTURE OF HAP1-PC7 COMPLEXED TO THE UAS OF CYC7 (2000) (0)
Crystal structure of yeast Esa1 HAT domain complexed with H4K16CoA bisubstrate inhibitor (2011) (0)
Crystal structure of yeast Esa1(C304S) mutant complexed with Coenzyme A (2002) (0)
Reply to: Acetyl-CoA is produced by the citrate synthase homology module of ATP-citrate lyase (2021) (0)
Structure And Chemistry Of The Human P300/CBP And Yeast Rtt109 Histone Acetyltransferases (2009) (0)
Crystal structure of PI3K p110gamma catalytical domain in complex with organoruthenium inhibitor E5E2 (2008) (0)
Crystal Structure of Wild Type BRAF kinase domain in complex with organometallic inhibitor CNS292 (2011) (0)
Cryo-EM structure of human NatE complex (NatA/Naa50) (2020) (0)
CRYSTAL STRUCTURE OF TETRAHYMENA GCN5 WITH BOUND ACETYL-COENZYME A (1999) (0)
CRYSTAL STRUCTURE OF YEAST ESA1 HISTONE ACETYLTRANSFERASE DOMAIN COMPLEXED WITH COENZYME A (2000) (0)
Crystal structure of human NatF (hNaa60) homodimer bound to Coenzyme A (2016) (0)
HAT DOMAIN OF GCN5 FROM SACCHAROMYCES CEREVISIAE (1999) (0)
Structure of the Tetrameric p53 Tumor Suppressor Bound to DNA (2002) (0)
Crystal structure of p300 histone acetyltransferase domain in complex with an inhibitor, Acetonyl-Coenzyme A (2014) (0)
Structure of Ovarian Tumor (OTU) domain in complex with Ubiquitin (2008) (0)
Crystal structure of NatD (Naa40p) bound to acetyl CoA (2015) (0)
Structure of the Tetrarneric p53 Tumor Supressor Bound to DNA (2000) (0)
Hst2 bound to ADP-HPD and Acetylated histone H4 (2007) (0)
UBN1 peptide bound to H3.3/H4/Asf1 (2015) (0)
Crystal structure of the DnaK C-terminus (Dnak-SBD-A) (2014) (0)
Author Correction: Molecular basis for acetyl-CoA production by ATP-citrate lyase (2020) (0)
CRYSTAL STRUCTURE OF THE PCAF/COENZYME-A COMPLEX (1999) (0)
BRAFV600E Kinase Domain In Complex with Chemically Linked Vemurafenib Inhibitor VEM-BISAMIDE (2016) (0)
Structure and chemistry of the human p300/CBP and yeast Rtt109 histone acetyltransferase (2009) (0)
The NatA (Naa10p/Naa15p) amino-terminal acetyltrasferase complex bound to AcCoA (2013) (0)
Structure of human ATP citrate lyase E599Q mutant in complex with Mg2+, citrate, ATP and CoA (2019) (0)
CTCF binding site sequence differences are associated with unique regulatory and functional trends during embryonic stem cell differentiation (2014) (0)
Human MOF E350Q crystal structure with active site lysine partially acetylated (2011) (0)
Structure of human ATP citrate lyase (2020) (0)
Structure of F71N mutant of p18INK4c (2002) (0)
Crystal Structure of NatD bound to H4/H2A peptide and CoA (2015) (0)
Cryo-EM structure of human NatE/HYPK complex (2020) (0)
Crystal structure of PAK1 in complex with an inhibitor compound FRAX1036 (2016) (0)
Molecular Basis for Regulation of Mammalian Fatty Acid Synthase (2022) (0)
Elk-1/DNA structure reveals how DNA-distal residues effect ETS-domain recognition of DNA. (2000) (0)
Crystal Structure of Leu3 DNA-binding domain with a single H50C mutation complexed with a 15mer DNA duplex (2006) (0)
Structure-Function Studies of the BTB / POZ Transcriptional Repression Domain from the Promyelocytic Leukemia Zinc Finger Oncoprotein 1 (1999) (0)
Human MOF K274P crystal structure (2016) (0)
BRAF in complex with an organic inhibitor 7898734 (2012) (0)
Allosteric role of the citrate synthase homology domain of ATP citrate lyase (2023) (0)
Crystal structure of human NatD (NAA40) bound to a bisubstrate analogue (2021) (0)
Crystal structure of PAK1 kinase domain with ruthenium complex DW1 (2009) (0)
Crystal structure of a PPRl-DNA complex: DNA recognition by proteins containing a ZujCys^ binuclear cluster (2007) (0)
Crystal Structure of HPV E7 CR3 domain (2005) (0)
Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours (2017) (0)
Crystal structure of human NatD (NAA40) bound to a bisubstrate analogue with a C-3 linker (2021) (0)
Structure of human ATP citrate lyase in complex with acetyl-CoA and oxaloacetate (2019) (0)
Crystal Structure of RTT109-AC-COA Complex (2008) (0)
Crystal Structure of a Leu3 DNA-binding domain complexed with a 15mer DNA duplex (2006) (0)
Crystal structure of human NatF (hNaa60) bound to a bisubstrate analogue (2016) (0)
Hait Sphingosine-1-Phosphate Regulation of Histone Acetylation in the Nucleus (2010) (0)
Local refinement of human ATP citrate lyase E599Q mutant ASH domain (2021) (0)
Crystal Structure of yHst2 bound to the intermediate analogue ADP-HPD, and and aceylated H4 peptide (2007) (0)
Structure of the Histone Acetyltransferase Domains of the GCN5, P/CAF and ESA1 Transcriptional Coactivators (2000) (0)
Crystal structure of the DnaK C-terminus with the inhibitor PET-16 (2014) (0)
ELK-1/DNA STRUCTURE REVEALS HOW RESIDUES DISTAL FROM DNA-BINDING SURFACE AFFECT DNA-RECOGNITION (2000) (0)
Crystal structure of the DnaK C-terminus with the substrate peptide NRLLLTG (2014) (0)
Epigenetics meets metabolism through PHB-mediated histone H3.3 deposition by HIRA. (2017) (0)
14-3-3 Interaction with Histone H3 Involves a Dual Modiﬁcation Pattern of Phosphoacetylation (cid:1) (2008) (0)
Structure-Based Design of Cdk4/6-Specific Inhibitors (2005) (0)
Crystal Structure of Yeast UBP3-associated Protein BRE5 (2005) (0)
P238: Discovery of the phenotypic landscape and mechanistic understanding of NAA10-related and NAA15-related neurodevelopmental syndromes, using mouse models and iPSCs* (2023) (0)
Hst2 bound to ADP-HPD, acetyllated histone H4 and nicotinamide (2007) (0)
SERUM RESPONSE FACTOR ACCESSORY PROTEIN 1A (SAP-1)/DNA COMPLEX (1999) (0)
The NatA (Naa10p/Naa15p) amino-terminal acetyltransferase complex bound to a bisubstrate analog (2013) (0)
The Human NatA (Naa10/Naa15) amino-terminal acetyltransferase complex bound to HYPK (2018) (0)
Structure of p18INK4c (F82Q) (2002) (0)
Structure and Function of the AIB1 (Amplified in Breast Cancer-1) Protein (2002) (0)
Crystal structure of the retinoblastoma tumour suppressor protein bound to E2F peptide (2003) (0)
Crystal Structure of the Erythrocyte Spectrin Tetramerization Domain Complex (2010) (0)
Molecular basis for N-terminal acetylation by human NatE and its modulation by HYPK (2020) (0)
Characterization of histone acylations links chromatin modifications with metabolism (2017) (0)
Crystal structure of yeast Esa1 E338Q HAT domain bound to coenzyme A with active site lysine acetylated (2011) (0)
Title Salicylate , diflunisal and their metabolites inhibit CBP / p 300 and exhibit anticancer activity (2019) (0)
Crystal Structure of Tetrahymena GCN5 With Bound Coenzyme A and a 19-residue Histone H4 Peptide (2004) (0)
Structure of the retinoblastoma protein pocket domain in complex with adenovirus E1A CR1 domain (2007) (0)
Crystal structure of PAK1 kinase domain with the ruthenium phthalimide complex (2012) (0)
Naa50p amino-terminal acetyltransferase bound to substrate peptide fragment and CoA (2011) (0)
Structure studies on the retinoblastoma tumour suppressor protein and its role in the cell cycle (2002) (0)
Human p70s6k1 with ruthenium-based inhibitor FL772 (2015) (0)
Rational design of a genetically encoded NMR zinc sensor (2023) (0)
Structure-Based Design of Molecules to Reactivate Tumor-Derived p53 Mutations (2006) (0)
yeast Deubiquitinase Ubp3 and Bre5 cofactor complex (2007) (0)
CRYSTAL STRUCTURE OF PUT3/DNA COMPLEX (1998) (0)
Biochemical characterization of the bile acid synthetic enzyme 3β‐hydroxy‐Δ5‐C27 steroid dehydrogenase/isomerase type VII (2022) (0)
as an Effector Protein Rab 35 Controls Actin Bundling by Recruiting Fascin (2009) (0)
The Human NatA (Naa10/Naa15) amino-terminal acetyltransferase complex (2018) (0)
Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD (cid:1) -dependent Sir2 histone (cid:1) protein deacetylases (2004) (0)
AD Award Number : DAMD 17-011-0461 TITLE : Structure and Function of AIB 1 ( Amplified in Breast Cancer-1 ) Protein (0)
TETRAHYMENA GCN5 WITH BOUND BISUBSTRATE ANALOG INHIBITOR (2002) (0)
Crystal structure of PAK1 kinase domain in complex with FRAX597 inhibitor (2013) (0)
Semi-synthetic CoA-α-Synuclein Constructs Trap N-terminal Acetyltransferase NatB for Binding Mechanism Studies (2023) (0)
Molecular Characterization of the HIRA Histone Chaperone Complex from Chaetomium thermophilum (2020) (0)
Crystal structure of selenomethionine labeled SpNatD (2015) (0)
CRYSTAL STRUCTURE OF TETRAHYMENA GCN5 (1999) (0)
Noncatalytic regulation of 18S rRNA methyltransferase DIMT1 in acute myeloid leukemia. (2023) (0)
Molecular role of NAA38 in thermostability and catalytic activity of the human NatC N-terminal acetyltransferase. (2022) (0)
Crystal structure of PAK1 kinase domain with ruthenium complex lambda-FL172 (2009) (0)
Human MOF C316S, E350Q crystal structure (2016) (0)
Crystal structure of Naa10 (Ard1) bound to AcCoA (2013) (0)
Crystal structure of the KA1 domain from human Chk1 (2017) (0)
Crystal structure of the mouse p53 core domain (2006) (0)
Crystal structure of Naa80 bound to a bisubstrate analogue (2018) (0)
Crystal Structure of Tetrahymena GCN5 with Bound Coenzyme A and a 19-residue Histone H3 Peptide (2003) (0)

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Harvard University
University of Pennsylvania
Institute of Cancer Research
University of California, Berkeley
University of Marburg

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