Ronen Marmorstein
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Researcher ORCID ID = 0000-0003-4373-4752
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Ronen Marmorsteinbiology Degrees
Biology
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Molecular Biology
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Biochemistry
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Biology
Ronen Marmorstein's Degrees
- PhD Biochemistry University of Pennsylvania
- Bachelors Chemistry University of California, Berkeley
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(Suggest an Edit or Addition)Ronen Marmorstein's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate (2009) (881)
- p53 Sites Acetylated In Vitro by PCAF and p300 Are Acetylated In Vivo in Response to DNA Damage (1999) (816)
- Acetylation of the p53 DNA-binding domain regulates apoptosis induction. (2006) (727)
- Crystal structure of trp represser/operator complex at atomic resolution (1988) (653)
- DNA recognition by GAL4: structure of a protein-DNA complex (1992) (633)
- Phosphorylation of serine 10 in histone H3 is functionally linked in vitro and in vivo to Gcn5-mediated acetylation at lysine 14. (2000) (587)
- Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor. (2010) (553)
- Autophagy mediates degradation of nuclear lamina (2015) (450)
- Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours (2017) (408)
- The structural basis of protein acetylation by the p300/CBP transcriptional coactivator (2008) (397)
- Histone acetyltransferases: function, structure, and catalysis. (2001) (381)
- Writers and readers of histone acetylation: structure, mechanism, and inhibition. (2014) (369)
- Histone modifying enzymes: structures, mechanisms, and specificities. (2009) (301)
- Chemistry of acetyl transfer by histone modifying enzymes: structure, mechanism and implications for effector design (2007) (254)
- Structure of Tetrahymena GCN5 bound to coenzyme A and a histone H3 peptide (1999) (252)
- A tight junction-associated Merlin-angiomotin complex mediates Merlin's regulation of mitogenic signaling and tumor suppressive functions. (2011) (248)
- Structure of the Human Papillomavirus E7 Oncoprotein and Its Mechanism for Inactivation of the Retinoblastoma Tumor Suppressor* (2006) (219)
- Catalytic Mechanism and Function of Invariant Glutamic Acid 173 from the Histone Acetyltransferase GCN5 Transcriptional Coactivator* (1999) (217)
- Protein modules that manipulate histone tails for chromatin regulation (2001) (203)
- Maintenance of low histone ubiquitylation by Ubp10 correlates with telomere-proximal Sir2 association and gene silencing. (2005) (198)
- Structurally sophisticated octahedral metal complexes as highly selective protein kinase inhibitors. (2011) (194)
- Structural basis for DNA recognition by FoxO1 and its regulation by posttranslational modification. (2008) (189)
- Structural basis for sirtuin function: what we know and what we don't. (2010) (189)
- Targeting large kinase active site with rigid, bulky octahedral ruthenium complexes. (2008) (186)
- Structure and function of histone acetyltransferases (2001) (178)
- Inhibition of Eukaryotic DNA Replication by Geminin Binding to Cdt1 (2000) (176)
- Crystal structure and mechanism of histone acetylation of the yeast GCN5 transcriptional coactivator. (1999) (174)
- Structure of a human ASF1a–HIRA complex and insights into specificity of histone chaperone complex assembly (2006) (173)
- Concurrent MEK2 mutation and BRAF amplification confer resistance to BRAF and MEK inhibitors in melanoma. (2013) (173)
- Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD(+)-dependent Sir2 histone/protein deacetylases. (2004) (172)
- Structure and chemistry of the p300/CBP and Rtt109 histone acetyltransferases: implications for histone acetyltransferase evolution and function. (2008) (167)
- Structure of histone acetyltransferases. (2001) (164)
- Human immunodeficiency virus type 1 Tat protein inhibits the SIRT1 deacetylase and induces T cell hyperactivation. (2008) (163)
- The catalytic mechanism of the ESA1 histone acetyltransferase involves a self-acetylated intermediate (2002) (162)
- Crystal structure of yeast Esa1 suggests a unified mechanism for catalysis and substrate binding by histone acetyltransferases. (2000) (161)
- Crystal structure of a PPR1-DNA complex: DNA recognition by proteins containing a Zn2Cys6 binuclear cluster. (1994) (160)
- Structural basis for histone and phosphohistone binding by the GCN5 histone acetyltransferase. (2003) (153)
- Crystal structure of the retinoblastoma tumor suppressor protein bound to E2F and the molecular basis of its regulation (2003) (153)
- Crystal structure of the histone acetyltransferase domain of the human PCAF transcriptional regulator bound to coenzyme A (1999) (150)
- Structure of the p53 Core Domain Dimer Bound to DNA*♦ (2006) (134)
- A Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles. (2017) (131)
- Structure and substrate binding properties of cobB, a Sir2 homolog protein deacetylase from Escherichia coli. (2004) (131)
- A mechanism-based inactivator for histone demethylase LSD1. (2006) (131)
- Molecular Basis for Amino-Terminal Acetylation by the Heterodimeric NatA Complex (2013) (129)
- Structure and Mechanism of Lysine-specific Demethylase Enzymes* (2007) (124)
- 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBER (2006) (123)
- Characterization of histone acylations links chromatin modifications with metabolism (2017) (122)
- The microtubule-associated tau protein has intrinsic acetyltransferase activity (2013) (121)
- Fungal Rtt109 histone acetyltransferase is an unexpected structural homolog of metazoan p300/CBP (2008) (121)
- PPT1 Promotes Tumor Growth and Is the Molecular Target of Chloroquine Derivatives in Cancer. (2018) (118)
- MYST protein acetyltransferase activity requires active site lysine autoacetylation (2012) (118)
- Solution structure of the DNA-binding domain of Cd2-GAL4 from S. cerevisiae (1992) (116)
- Structure and activity of enzymes that remove histone modifications. (2005) (115)
- Crystal structure of trp represser/operator complex at atomic resolution (1988) (111)
- Structural Basis for Sirtuin Activity and Inhibition* (2012) (111)
- DNA sequence preferences of GAL4 and PPR1: how a subset of Zn2 Cys6 binuclear cluster proteins recognizes DNA (1996) (111)
- Structures of SAP-1 bound to DNA targets from the E74 and c-fos promoters: insights into DNA sequence discrimination by Ets proteins. (1998) (110)
- Human UBN1 Is an Ortholog of Yeast Hpc2p and Has an Essential Role in the HIRA/ASF1a Chromatin-Remodeling Pathway in Senescent Cells (2008) (108)
- Structural Basis for Ubiquitin Recognition by the Otu1 Ovarian Tumor Domain Protein* (2008) (108)
- Structure of the yeast Hst2 protein deacetylase in ternary complex with 2'-O-acetyl ADP ribose and histone peptide. (2003) (103)
- Structure and autoregulation of the yeast Hst2 homolog of Sir2 (2003) (103)
- Structure of the GCN5 histone acetyltransferase bound to a bisubstrate inhibitor (2002) (102)
- Structure of the Elk-1–DNA complex reveals how DNA-distal residues affect ETS domain recognition of DNA (2000) (102)
- FRAX597, a Small Molecule Inhibitor of the p21-activated Kinases, Inhibits Tumorigenesis of Neurofibromatosis Type 2 (NF2)-associated Schwannomas* (2013) (101)
- Ubinuclein-1 confers histone H3.3-specific-binding by the HIRA histone chaperone complex (2015) (100)
- Site-specific introduction of an acetyl-lysine mimic into peptides and proteins by cysteine alkylation. (2010) (99)
- Structure and function of the SWIRM domain, a conserved protein module found in chromatin regulatory complexes (2006) (99)
- 14-3-3 Interaction with Histone H3 Involves a Dual Modification Pattern of Phosphoacetylation (2008) (99)
- Structure-function studies of the BTB/POZ transcriptional repression domain from the promyelocytic leukemia zinc finger oncoprotein. (1999) (98)
- Structure of histone deacetylases: insights into substrate recognition and catalysis. (2001) (98)
- Structure and function of bromodomains in chromatin-regulating complexes. (2001) (96)
- Application of a fluorescent histone acetyltransferase assay to probe the substrate specificity of the human p300/CBP-associated factor. (2000) (95)
- Structure of SET domain proteins: a new twist on histone methylation. (2003) (92)
- Biochemical and cellular analysis of Ogden syndrome reveals downstream Nt-acetylation defects (2014) (91)
- Crystal Structure of the Mouse p53 Core DNA-binding Domain at 2.7 Å Resolution* (2001) (88)
- The art of filling protein pockets efficiently with octahedral metal complexes. (2012) (87)
- Crystal Structure of the Stress-Inducible Human Heat Shock Protein 70 Substrate-Binding Domain in Complex with Peptide Substrate (2014) (87)
- Structural basis for dimerization in DNA recognition by Gal4. (2008) (86)
- Structure of the retinoblastoma protein bound to adenovirus E1A reveals the molecular basis for viral oncoprotein inactivation of a tumor suppressor. (2007) (86)
- Crystal structure of a PUT3–DNA complex reveals a novel mechanism for DMA recognition by a protein containing a Zn2Cys6 binuclear cluster (1997) (85)
- Structure of a Ternary Naa50p (NAT5/SAN) N-terminal Acetyltransferase Complex Reveals the Molecular Basis for Substrate-specific Acetylation* (2011) (84)
- Human CABIN1 Is a Functional Member of the Human HIRA/UBN1/ASF1a Histone H3.3 Chaperone Complex (2011) (83)
- Acridine derivatives activate p53 and induce tumor cell death through bax (2005) (82)
- Histone acetyltransferases: Rising ancient counterparts to protein kinases (2013) (81)
- Molecular basis for Gcn5/PCAF histone acetyltransferase selectivity for histone and nonhistone substrates. (2003) (80)
- Structure and chemistry of the Sir2 family of NAD+-dependent histone/protein deactylases. (2004) (79)
- Crystal structure of the CDK4/6 inhibitory protein p18INK4c provides insights into ankyrin-like repeat structure/function and tumor-derived p16INK4 mutations (1998) (79)
- Structure of a HAP1–DNA complex reveals dramatically asymmetric DNA binding by a homodimeric protein (1999) (79)
- Toward the development of a potent and selective organoruthenium mammalian sterile 20 kinase inhibitor. (2009) (73)
- Crystal Structure of a p53 Core Tetramer Bound to DNA (2008) (72)
- Crystal structure of a ternary SAP-1/SRF/c-fos SRE DNA complex. (2001) (72)
- Inhibition of Epstein-Barr Virus OriP Function by Tankyrase, a Telomere-Associated Poly-ADP Ribose Polymerase That Binds and Modifies EBNA1 (2005) (71)
- The crystal structure of BRAF in complex with an organoruthenium inhibitor reveals a mechanism for inhibition of an active form of BRAF kinase. (2009) (70)
- Structure of the α-tubulin acetyltransferase, αTAT1, and implications for tubulin-specific acetylation (2012) (69)
- Crystal structure and functional interpretation of the erythrocyte spectrin tetramerization domain complex. (2010) (69)
- Structure and dimerization of the kinase domain from yeast Snf1, a member of the Snf1/AMPK protein family. (2006) (69)
- Molecular Basis for Oligomeric-DNA Binding and Episome Maintenance by KSHV LANA (2013) (65)
- Overexpression, Purification, Characterization, and Crystallization of the BTB/POZ Domain from the PLZF Oncoprotein* (1997) (63)
- Identification of Host-Chromosome Binding Sites and Candidate Gene Targets for Kaposi's Sarcoma-Associated Herpesvirus LANA (2012) (63)
- Structural basis for nicotinamide inhibition and base exchange in Sir2 enzymes. (2007) (62)
- Structure of a Sir2 Substrate, Alba, Reveals a Mechanism for Deacetylation-induced Enhancement of DNA Binding* (2003) (62)
- Identification of a novel family of BRAF(V600E) inhibitors. (2012) (62)
- The structural basis for the interaction between L-tryptophan and the Escherichia coli trp aporepressor. (1987) (62)
- Structure and mechanism of non‐histone protein acetyltransferase enzymes (2013) (61)
- Architectural Organization of the Metabolic Regulatory Enzyme Ghrelin O-Acyltransferase* (2013) (61)
- Structure of Vps75 and implications for histone chaperone function (2008) (60)
- The molecular basis for histone H4- and H2A-specific amino-terminal acetylation by NatD. (2015) (59)
- SIRT1 Contains N- and C-terminal Regions That Potentiate Deacetylase Activity* (2011) (59)
- Structure of the p300 Histone Acetyltransferase Bound to Acetyl-Coenzyme A and Its Analogues (2014) (54)
- The MEK/ERK Network as a Therapeutic Target in Human Cancer (2020) (54)
- Structure of the Rtt109-AcCoA/Vps75 complex and implications for chaperone-mediated histone acetylation. (2011) (54)
- Nuclear export modulates the cytoplasmic Sir2 homologue Hst2 (2006) (53)
- The Human Monocytic Leukemia Zinc Finger Histone Acetyltransferase Domain Contains DNA-binding Activity Implicated in Chromatin Targeting* (2007) (52)
- Salicylate, diflunisal and their metabolites inhibit CBP/p300 and exhibit anticancer activity (2016) (52)
- Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pK a Polar Moiety. (2015) (52)
- Coexpression of proteins in bacteria using T7-based expression plasmids: expression of heteromeric cell-cycle and transcriptional regulatory complexes. (2000) (51)
- Structural Basis for the Inhibition of HSP70 and DnaK Chaperones by Small-Molecule Targeting of a C-Terminal Allosteric Pocket (2014) (50)
- Structural determinants and cellular environment define processed actin as the sole substrate of the N-terminal acetyltransferase NAA80 (2018) (50)
- Structure-based design of an organoruthenium phosphatidyl-inositol-3-kinase inhibitor reveals a switch governing lipid kinase potency and selectivity. (2008) (50)
- Biochemical analysis of MST1 kinase: elucidation of a C-terminal regulatory region. (2008) (49)
- Multiple roles for acetylation in the interaction of p300 HAT with ATF-2. (2007) (48)
- Oligomerization properties of the viral oncoproteins adenovirus E1A and human papillomavirus E7 and their complexes with the retinoblastoma protein. (2000) (47)
- Structure of Human NatA and Its Regulation by the Huntingtin Interacting Protein HYPK. (2018) (46)
- The N-terminal Acetyltransferase Naa10/ARD1 Does Not Acetylate Lysine Residues* (2016) (45)
- Discovery of Spiro Oxazolidinediones as Selective, Orally Bioavailable Inhibitors of p300/CBP Histone Acetyltransferases (2017) (44)
- Stereochemical effects of L-tryptophan and its analogues on trp repressor's affinity for operator-DNA. (1989) (44)
- Identification and Characterization of Small Molecule Human Papillomavirus E6 Inhibitors (2014) (43)
- Molecular Basis for Histone Acetyltransferase Regulation by Binding Partners, Associated Domains, and Autoacetylation. (2016) (41)
- Nonenzymatic Protein Acetylation Detected by NAPPA Protein Arrays. (2015) (41)
- Implications for the evolution of eukaryotic amino-terminal acetyltransferase (NAT) enzymes from the structure of an archaeal ortholog (2013) (40)
- Crystal Structure of the Golgi-Associated Human Nα-Acetyltransferase 60 Reveals the Molecular Determinants for Substrate-Specific Acetylation. (2016) (39)
- Erratum: Crystal structure of trp represser/operator complex at atomic resolution (Nature (1988) 335 (321-329)) (1988) (39)
- Viral Reprogramming of the Daxx Histone H3.3 Chaperone during Early Epstein-Barr Virus Infection (2014) (38)
- Development of small-molecule inhibitors of the group I p21-activated kinases, emerging therapeutic targets in cancer. (2010) (38)
- Identification of BRAF inhibitors through in silico screening. (2008) (36)
- DAXX represents a new type of protein-folding enabler (2021) (35)
- Phenotypic and biochemical analysis of an international cohort of individuals with variants in NAA10 and NAA15. (2019) (35)
- Functional activity of the H3.3 histone chaperone complex HIRA requires trimerization of the HIRA subunit (2018) (33)
- A Molecular Prospective for HIRA Complex Assembly and H3.3-Specific Histone Chaperone Function. (2017) (31)
- Menin and Daxx Interact to Suppress Neuroendocrine Tumors through Epigenetic Control of the Membrane Metallo-Endopeptidase. (2017) (31)
- Identification and characterization of novel sirtuin inhibitor scaffolds. (2009) (30)
- Protein N-Terminal Acetylation: Structural Basis, Mechanism, Versatility, and Regulation. (2020) (29)
- Probing the interaction between NatA and the ribosome for co-translational protein acetylation (2017) (28)
- Fungal Rtt109 histone acetyltransferase is an unexpected structural homolog of metazoan p300/CBP (2008) (28)
- Structure and Mechanism of Acetylation by the N-Terminal Dual Enzyme NatA/Naa50 Complex. (2019) (28)
- Identification and characterization of small molecule antagonists of pRb inactivation by viral oncoproteins. (2012) (28)
- Identification of an ubinuclein 1 region required for stability and function of the human HIRA/UBN1/CABIN1/ASF1a histone H3.3 chaperone complex. (2012) (27)
- Structural Basis for Interaction between the Ubp3 Deubiquitinating Enzyme and Its Bre5 Cofactor* (2005) (27)
- Modulation of DNA-binding domains for sequence-specific DNA recognition. (2003) (26)
- The structurally disordered KRAB repression domain is incorporated into a protease resistant core upon binding to KAP-1-RBCC domain. (2007) (26)
- Catalytic mechanism of histone acetyltransferase p300: from the proton transfer to acetylation reaction. (2014) (26)
- Chaperone-mediated acetylation of histones by Rtt109 identified by quantitative proteomics. (2013) (25)
- Structure and Biochemical Characterization of Protein Acetyltransferase from Sulfolobus solfataricus* (2009) (25)
- Biochemical and structural characterization of recombinant histone acetyltransferase proteins. (2004) (24)
- Molecular basis for bre5 cofactor recognition by the ubp3 deubiquitylating enzyme. (2007) (24)
- Molecular basis for N-terminal acetylation by human NatE and its modulation by HYPK (2020) (24)
- Structure of HAP1-18–DNA implicates direct allosteric effect of protein–DNA interactions on transcriptional activation (1999) (24)
- An alkaline phosphatase protection assay to investigate trp repressor/operator interactions. (1991) (23)
- Dissecting the Molecular Roles of Histone Chaperones in Histone Acetylation by Type B Histone Acetyltransferases (HAT-B)* (2015) (21)
- Crystals of the trp repressor-operator complex suitable for X-ray diffraction analysis. (1987) (21)
- Structural and chemical basis of histone acetylation. (2004) (20)
- FRAX 597 , a Small Molecule Inhibitor of the p 21-activated Kinases , Inhibits Tumorigenesis of Neurofibromatosis Type 2 ( NF 2 )-associated Schwannomas * (2013) (19)
- High-resolution structure of the p53 core domain: implications for binding small-molecule stabilizing compounds. (2006) (19)
- When viral oncoprotein meets tumor suppressor: a structural view. (2006) (19)
- Chemically Linked Vemurafenib Inhibitors Promote an Inactive BRAFV600E Conformation. (2016) (18)
- Development of a novel class of B-Raf(V600E)-selective inhibitors through virtual screening and hierarchical hit optimization. (2012) (18)
- Structure of a Leu3-DNA complex: recognition of everted CGG half-sites by a Zn2Cys6 binuclear cluster protein. (2006) (18)
- Ankyrin for methylated lysines (2008) (18)
- Mechanism of BRAF Activation through Biochemical Characterization of the Recombinant Full‐Length Protein (2018) (16)
- Molecular basis for acetyl-CoA production by ATP-citrate lyase (2019) (16)
- ATP-citrate lyase multimerization is required for coenzyme-A substrate binding and catalysis (2019) (16)
- Development of Organometallic S6K1 Inhibitors (2014) (15)
- Conserved Lysine Acetylation within the Microtubule-Binding Domain Regulates MAP2/Tau Family Members (2016) (15)
- Structural and Functional Role of Acetyltransferase hMOF K274 Autoacetylation* (2016) (14)
- Molecular Basis for Cohesin Acetylation by Establishment of Sister Chromatid Cohesion N-Acetyltransferase ESCO1* (2016) (14)
- Different regions of the HPV-E7 and Ad-E1A viral oncoproteins bind competitively but through distinct mechanisms to the CH1 transactivation domain of p300. (2012) (14)
- Crystal structure and mechanism of histone acetylation of the yeast GCN 5 transcriptional coactivator (1999) (13)
- Crystallization of Macromolecules (2003) (13)
- Red Wine, Toast of the Town (Again) (2013) (13)
- Drugging the “Undruggable” MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers (2021) (13)
- Structural Basis for MARK1 Kinase Autoinhibition by Its KA1 Domain. (2018) (12)
- The scaffolding protein JADE1 physically links the acetyltransferase subunit HBO1 with its histone H3–H4 substrate (2018) (12)
- Actin's N‐terminal acetyltransferase uncovered (2018) (11)
- Intramolecular autoinhibition of checkpoint kinase 1 is mediated by conserved basic motifs of the C-terminal kinase–associated 1 domain (2017) (11)
- Molecular basis for chromatin assembly and modification by multiprotein complexes (2018) (11)
- Structure-based Design of p18INK4cProteins with Increased Thermodynamic Stability and Cell Cycle Inhibitory Activity* (2002) (11)
- Molecular basis for N-terminal alpha-synuclein acetylation by human NatB (2020) (11)
- Phenotypic and biochemical analysis of an international cohort of individuals with variants in NAA10 and NAA15. (2020) (10)
- Rap1‐mediated nucleosome displacement can regulate gene expression in senescent cells without impacting the pace of senescence (2019) (10)
- The copper chaperone CCS facilitates copper binding to MEK1/2 to promote kinase activation. (2021) (10)
- P-donor ligand containing ruthenium half-sandwich complexes as protein kinase inhibitors (2011) (10)
- STRUCTURES OF SAP-1 BOUND TO DNA SEQUENCES FROM THE E74 AND C-FOS PROMOTERS PROVIDE INSIGHTS INTO HOW ETS PROTEINS DISCRIMINATE BETWEEN RELATED DNA TARGETS (1998) (9)
- Insights into structure and function of GCN5/PCAF and yEsa 1 histone acetyltransferase domains:. (2003) (9)
- Structure of HAP1-PC7 bound to DNA: implications for DNA recognition and allosteric effects of DNA-binding on transcriptional activation. (2000) (9)
- Opposing Functions of the N-terminal Acetyltransferases Naa50 and NatA in Sister-chromatid Cohesion* (2016) (8)
- Dehydrogenases, NAD, and transcription--what's the connection? (2002) (8)
- The HIRA histone chaperone complex subunit UBN1 harbors H3/H4- and DNA-binding activity (2019) (7)
- Author Correction: Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours (2018) (7)
- 6-Nitro-L-tryptophan: a novel spectroscopic probe of trp aporepressor and human serum albumin. (1988) (7)
- Specificity and Versatility of Substrate Binding Sites in Four Catalytic Domains of Human N-Terminal Acetyltransferases (2012) (6)
- Discovery of Spirohydantoins as Selective, Orally Bioavailable Inhibitors of p300/CBP Histone Acetyltransferases. (2021) (6)
- N-(7-Cyano-6-(4-fluoro-3-(2-(3-(trifluoromethyl)phenyl)acetamido)phenoxy)benzo[d]thiazol-2-yl)cyclopropanecarboxamide (TAK632) Promotes Inhibition of BRAF through the Induction of Inhibited Dimers. (2018) (6)
- CTCF-Induced Circular DNA Complexes Observed by Atomic Force Microscopy. (2018) (6)
- Generation and characterization of monoclonal antibodies against the E6 and E7 oncoproteins of HPV. (2001) (6)
- Naa12 compensates for Naa10 in mice in the amino-terminal acetylation pathway (2020) (5)
- N-alpha-acetylation of Huntingtin protein increases its propensity to aggregate (2021) (5)
- Co-expression of proteins in E. coli using dual expression vectors. (2003) (5)
- Remodelin Is a Cryptic Assay Interference Chemotype That Does Not Inhibit NAT10-Dependent Cytidine Acetylation. (2020) (5)
- Chapter 3:Structural Basis for Sequence-specific DNA Recognition by Transcription Factors and their Complexes (2008) (4)
- Structure and Mechanism of the trp Repressor/Operator System (1989) (4)
- Identification and synthesis of N-(thiophen-2-yl) benzamide derivatives as BRAF(V600E) inhibitors. (2013) (4)
- Molecular mechanism of N-terminal acetylation by the ternary NatC complex (2021) (4)
- Structure of the Sir2 Family of NAD+-Dependent Histone/Protein Deacetylases (2006) (4)
- Transcription Initiation at Its Most Basic Level (2003) (4)
- Identi fi cation and Characterization of Small Molecule Human Papillomavirus E 6 Inhibitors (2014) (3)
- In Vitro Activity Assays for MYST Histone Acetyltransferases and Adaptation for High-Throughput Inhibitor Screening. (2016) (3)
- Author Correction: Molecular basis for acetyl-CoA production by ATP-citrate lyase (2019) (3)
- Structure of the alpha-tubulin acetyltransferase, alpha-TAT1 (2012) (3)
- CRYSTAL STRUCTURE OF TETRAHYMENA GCN5 WITH BOUND COENZYME A AND HISTONE H3 PEPTIDE (1999) (3)
- Identification and Characterization of a B-Raf Kinase Alpha Helix Critical for the Activity of MEK Kinase in MAPK Signaling (2020) (2)
- Erratum: CTCF binding site sequence differences are associated with unique regulatory and functional trends during embryonic stem cell differentiation (Nucleic Acids Research (2014) 42 (774-789) DOI:10.1093/nar/gkt910) (2014) (2)
- Expanding the Phenotypic spectrum of Ogden syndrome (NAA10-related neurodevelopmental syndrome) and NAA15-related neurodevelopmental syndrome (2022) (2)
- Structural and molecular determinants of CCS-mediated copper activation of MEK1/2 (2020) (2)
- Biochemical and structural analysis of N-terminal acetyltransferases. (2019) (2)
- Novel Bisubstrate Inhibitors for Protein N-Terminal Acetyltransferase D. (2021) (2)
- Allosteric role of a structural NADP+ molecule in glucose-6-phosphate dehydrogenase activity (2022) (2)
- Structural biology: Hypoxia response becomes crystal clear (2015) (2)
- The heme-regulated inhibitor kinase requires dimerization for heme-sensing activity (2022) (1)
- Unfolding Mechanisms and Conformational Stability of the Dimeric Endophilin N-BAR Domain (2021) (1)
- Crystal structure of p300 histone acetyltransferase domain in complex with a bisubstrate inhibitor, Lys-CoA (2008) (1)
- STRUCTURE OF A HAP1-18/DNA COMPLEX REVEALS THAT PROTEIN/DNA INTERACTIONS CAN HAVE DIRECT ALLOSTERIC EFFECTS ON TRANSCRIPTIONAL ACTIVATION (1999) (1)
- Novel bisubstrate inhibitors for protein N-terminal acetyltransferase D (2021) (1)
- Crystallization of Macromolecules (2003) (1)
- Molecular basis for acetyl-CoA production by ATP-citrate lyase (2019) (1)
- Enzymes of Epigenetics (2016) (1)
- Anticipating drug resistance in the MAP kinase pathway (2010) (1)
- Crystal structure of the mouse p53 core domain at 1.55 A (2006) (0)
- Tyrosine phosphorylation is critical for ACLY activity in lipid metabolism and cancer (2020) (0)
- Tyrosine phosphorylation of ACLY regulates lipid metabolism and oncogenesis in ALK positive Anaplastic Large Cell Lymphoma (2020) (0)
- Decameric ring structure of KSHV (HHV-8) latency-associated nuclear antigen (LANA) DNA binding domain (2013) (0)
- Cryo-EM structure of S. Pombe NatC complex with a Bisubstrate inhibitor and inositol hexaphosphate (2021) (0)
- Cryo-EM structure of human NatB complex (2020) (0)
- Expanding the phenotypic spectrum of NAA10-related neurodevelopmental syndrome and NAA15-related neurodevelopmental syndrome. (2023) (0)
- Non-catalytic regulation of 18S rRNA methyltransferase DIMT1 in acute myeloid leukemia (2023) (0)
- Archaeal amino-terminal acetyltransferase (NAT) bound to acetyl coenzyme A (2013) (0)
- CRYSTAL STRUCTURE OF P18-INK4C(INK6) (1998) (0)
- TITLE : Structure-Based Design of Molecules to Reactivate Tumor Derived p 53 Mutations (0)
- Crystal Structure of Tetrahymena GCN5 with Bound Coenzyme A and a Phosphorylated, 19-residue Histone H3 peptide (2003) (0)
- Structure-Based Design of CSDK4-Specific Inhibitors (2003) (0)
- Structure of ATP citrate lyase with CoA in a partially open conformation (2019) (0)
- Crystal Structure of FoxO1 DBD Bound to DBE1 DNA (2008) (0)
- Crystal structure of yeast Esa1 histone acetyltransferase E338Q mutant complexed with acetyl coenzyme A (2002) (0)
- Crystal structure of KA1-autoinhibited MARK1 kinase (2018) (0)
- Functional activity of the H3.3 histone chaperone complex HIRA requires trimerization of the HIRA subunit (2018) (0)
- Crystal structure of p300 histone acetyltransferase domain in complex with Acetyl-Coenzyme A (2014) (0)
- Mouse p53 core domain soaked with 2-propanol (2006) (0)
- Structure of death-associated protein Kinase 1 (dapk1) in complex with a ruthenium octasporine ligand (OSV) (2011) (0)
- Crystal Structure of the HAT domain of the human MOZ protein (2007) (0)
- Link between histone deubiquitination and protection of telomeres (2005) (0)
- A Novel Continuous Assay for the Mechanistic Characterization of Histone Deacetylases and Homologues Using a Small Molecule Fluorescent Substrate (2001) (0)
- Thetrprepressor/operator system: the crystallography of ligand-activated genetic regulation (1987) (0)
- Crystal Structure of the Vps75 Histone Chaperone (2008) (0)
- STRUCTURE OF HAP1-PC7 COMPLEXED TO THE UAS OF CYC7 (2000) (0)
- Crystal structure of yeast Esa1 HAT domain complexed with H4K16CoA bisubstrate inhibitor (2011) (0)
- Crystal structure of yeast Esa1(C304S) mutant complexed with Coenzyme A (2002) (0)
- Reply to: Acetyl-CoA is produced by the citrate synthase homology module of ATP-citrate lyase (2021) (0)
- Structure And Chemistry Of The Human P300/CBP And Yeast Rtt109 Histone Acetyltransferases (2009) (0)
- Crystal structure of PI3K p110gamma catalytical domain in complex with organoruthenium inhibitor E5E2 (2008) (0)
- Crystal Structure of Wild Type BRAF kinase domain in complex with organometallic inhibitor CNS292 (2011) (0)
- Cryo-EM structure of human NatE complex (NatA/Naa50) (2020) (0)
- CRYSTAL STRUCTURE OF TETRAHYMENA GCN5 WITH BOUND ACETYL-COENZYME A (1999) (0)
- CRYSTAL STRUCTURE OF YEAST ESA1 HISTONE ACETYLTRANSFERASE DOMAIN COMPLEXED WITH COENZYME A (2000) (0)
- Crystal structure of human NatF (hNaa60) homodimer bound to Coenzyme A (2016) (0)
- HAT DOMAIN OF GCN5 FROM SACCHAROMYCES CEREVISIAE (1999) (0)
- Structure of the Tetrameric p53 Tumor Suppressor Bound to DNA (2002) (0)
- Crystal structure of p300 histone acetyltransferase domain in complex with an inhibitor, Acetonyl-Coenzyme A (2014) (0)
- Structure of Ovarian Tumor (OTU) domain in complex with Ubiquitin (2008) (0)
- Crystal structure of NatD (Naa40p) bound to acetyl CoA (2015) (0)
- Structure of the Tetrarneric p53 Tumor Supressor Bound to DNA (2000) (0)
- Hst2 bound to ADP-HPD and Acetylated histone H4 (2007) (0)
- UBN1 peptide bound to H3.3/H4/Asf1 (2015) (0)
- Crystal structure of the DnaK C-terminus (Dnak-SBD-A) (2014) (0)
- Author Correction: Molecular basis for acetyl-CoA production by ATP-citrate lyase (2020) (0)
- CRYSTAL STRUCTURE OF THE PCAF/COENZYME-A COMPLEX (1999) (0)
- BRAFV600E Kinase Domain In Complex with Chemically Linked Vemurafenib Inhibitor VEM-BISAMIDE (2016) (0)
- Structure and chemistry of the human p300/CBP and yeast Rtt109 histone acetyltransferase (2009) (0)
- The NatA (Naa10p/Naa15p) amino-terminal acetyltrasferase complex bound to AcCoA (2013) (0)
- Structure of human ATP citrate lyase E599Q mutant in complex with Mg2+, citrate, ATP and CoA (2019) (0)
- CTCF binding site sequence differences are associated with unique regulatory and functional trends during embryonic stem cell differentiation (2014) (0)
- Human MOF E350Q crystal structure with active site lysine partially acetylated (2011) (0)
- Structure of human ATP citrate lyase (2020) (0)
- Structure of F71N mutant of p18INK4c (2002) (0)
- Crystal Structure of NatD bound to H4/H2A peptide and CoA (2015) (0)
- Cryo-EM structure of human NatE/HYPK complex (2020) (0)
- Crystal structure of PAK1 in complex with an inhibitor compound FRAX1036 (2016) (0)
- Molecular Basis for Regulation of Mammalian Fatty Acid Synthase (2022) (0)
- Elk-1/DNA structure reveals how DNA-distal residues effect ETS-domain recognition of DNA. (2000) (0)
- Crystal Structure of Leu3 DNA-binding domain with a single H50C mutation complexed with a 15mer DNA duplex (2006) (0)
- Structure-Function Studies of the BTB / POZ Transcriptional Repression Domain from the Promyelocytic Leukemia Zinc Finger Oncoprotein 1 (1999) (0)
- Human MOF K274P crystal structure (2016) (0)
- BRAF in complex with an organic inhibitor 7898734 (2012) (0)
- Allosteric role of the citrate synthase homology domain of ATP citrate lyase (2023) (0)
- Crystal structure of human NatD (NAA40) bound to a bisubstrate analogue (2021) (0)
- Crystal structure of PAK1 kinase domain with ruthenium complex DW1 (2009) (0)
- Crystal structure of a PPRl-DNA complex: DNA recognition by proteins containing a ZujCys^ binuclear cluster (2007) (0)
- Crystal Structure of HPV E7 CR3 domain (2005) (0)
- Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours (2017) (0)
- Crystal structure of human NatD (NAA40) bound to a bisubstrate analogue with a C-3 linker (2021) (0)
- Structure of human ATP citrate lyase in complex with acetyl-CoA and oxaloacetate (2019) (0)
- Crystal Structure of RTT109-AC-COA Complex (2008) (0)
- Crystal Structure of a Leu3 DNA-binding domain complexed with a 15mer DNA duplex (2006) (0)
- Crystal structure of human NatF (hNaa60) bound to a bisubstrate analogue (2016) (0)
- Hait Sphingosine-1-Phosphate Regulation of Histone Acetylation in the Nucleus (2010) (0)
- Local refinement of human ATP citrate lyase E599Q mutant ASH domain (2021) (0)
- Crystal Structure of yHst2 bound to the intermediate analogue ADP-HPD, and and aceylated H4 peptide (2007) (0)
- Structure of the Histone Acetyltransferase Domains of the GCN5, P/CAF and ESA1 Transcriptional Coactivators (2000) (0)
- Crystal structure of the DnaK C-terminus with the inhibitor PET-16 (2014) (0)
- ELK-1/DNA STRUCTURE REVEALS HOW RESIDUES DISTAL FROM DNA-BINDING SURFACE AFFECT DNA-RECOGNITION (2000) (0)
- Crystal structure of the DnaK C-terminus with the substrate peptide NRLLLTG (2014) (0)
- Epigenetics meets metabolism through PHB-mediated histone H3.3 deposition by HIRA. (2017) (0)
- 14-3-3 Interaction with Histone H3 Involves a Dual Modification Pattern of Phosphoacetylation (cid:1) (2008) (0)
- Structure-Based Design of Cdk4/6-Specific Inhibitors (2005) (0)
- Crystal Structure of Yeast UBP3-associated Protein BRE5 (2005) (0)
- P238: Discovery of the phenotypic landscape and mechanistic understanding of NAA10-related and NAA15-related neurodevelopmental syndromes, using mouse models and iPSCs* (2023) (0)
- Hst2 bound to ADP-HPD, acetyllated histone H4 and nicotinamide (2007) (0)
- SERUM RESPONSE FACTOR ACCESSORY PROTEIN 1A (SAP-1)/DNA COMPLEX (1999) (0)
- The NatA (Naa10p/Naa15p) amino-terminal acetyltransferase complex bound to a bisubstrate analog (2013) (0)
- The Human NatA (Naa10/Naa15) amino-terminal acetyltransferase complex bound to HYPK (2018) (0)
- Structure of p18INK4c (F82Q) (2002) (0)
- Structure and Function of the AIB1 (Amplified in Breast Cancer-1) Protein (2002) (0)
- Crystal structure of the retinoblastoma tumour suppressor protein bound to E2F peptide (2003) (0)
- Crystal Structure of the Erythrocyte Spectrin Tetramerization Domain Complex (2010) (0)
- Molecular basis for N-terminal acetylation by human NatE and its modulation by HYPK (2020) (0)
- Characterization of histone acylations links chromatin modifications with metabolism (2017) (0)
- Crystal structure of yeast Esa1 E338Q HAT domain bound to coenzyme A with active site lysine acetylated (2011) (0)
- Title Salicylate , diflunisal and their metabolites inhibit CBP / p 300 and exhibit anticancer activity (2019) (0)
- Crystal Structure of Tetrahymena GCN5 With Bound Coenzyme A and a 19-residue Histone H4 Peptide (2004) (0)
- Structure of the retinoblastoma protein pocket domain in complex with adenovirus E1A CR1 domain (2007) (0)
- Crystal structure of PAK1 kinase domain with the ruthenium phthalimide complex (2012) (0)
- Naa50p amino-terminal acetyltransferase bound to substrate peptide fragment and CoA (2011) (0)
- Structure studies on the retinoblastoma tumour suppressor protein and its role in the cell cycle (2002) (0)
- Human p70s6k1 with ruthenium-based inhibitor FL772 (2015) (0)
- Rational design of a genetically encoded NMR zinc sensor (2023) (0)
- Structure-Based Design of Molecules to Reactivate Tumor-Derived p53 Mutations (2006) (0)
- yeast Deubiquitinase Ubp3 and Bre5 cofactor complex (2007) (0)
- CRYSTAL STRUCTURE OF PUT3/DNA COMPLEX (1998) (0)
- Biochemical characterization of the bile acid synthetic enzyme 3β‐hydroxy‐Δ5‐C27 steroid dehydrogenase/isomerase type VII (2022) (0)
- as an Effector Protein Rab 35 Controls Actin Bundling by Recruiting Fascin (2009) (0)
- The Human NatA (Naa10/Naa15) amino-terminal acetyltransferase complex (2018) (0)
- Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD (cid:1) -dependent Sir2 histone (cid:1) protein deacetylases (2004) (0)
- AD Award Number : DAMD 17-011-0461 TITLE : Structure and Function of AIB 1 ( Amplified in Breast Cancer-1 ) Protein (0)
- TETRAHYMENA GCN5 WITH BOUND BISUBSTRATE ANALOG INHIBITOR (2002) (0)
- Crystal structure of PAK1 kinase domain in complex with FRAX597 inhibitor (2013) (0)
- Semi-synthetic CoA-α-Synuclein Constructs Trap N-terminal Acetyltransferase NatB for Binding Mechanism Studies (2023) (0)
- Molecular Characterization of the HIRA Histone Chaperone Complex from Chaetomium thermophilum (2020) (0)
- Crystal structure of selenomethionine labeled SpNatD (2015) (0)
- CRYSTAL STRUCTURE OF TETRAHYMENA GCN5 (1999) (0)
- Noncatalytic regulation of 18S rRNA methyltransferase DIMT1 in acute myeloid leukemia. (2023) (0)
- Molecular role of NAA38 in thermostability and catalytic activity of the human NatC N-terminal acetyltransferase. (2022) (0)
- Crystal structure of PAK1 kinase domain with ruthenium complex lambda-FL172 (2009) (0)
- Human MOF C316S, E350Q crystal structure (2016) (0)
- Crystal structure of Naa10 (Ard1) bound to AcCoA (2013) (0)
- Crystal structure of the KA1 domain from human Chk1 (2017) (0)
- Crystal structure of the mouse p53 core domain (2006) (0)
- Crystal structure of Naa80 bound to a bisubstrate analogue (2018) (0)
- Crystal Structure of Tetrahymena GCN5 with Bound Coenzyme A and a 19-residue Histone H3 Peptide (2003) (0)
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