Rosa Beddington
English developmental biologist
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Rosa Beddington's Degrees
- Bachelors Biology University of Oxford
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(Suggest an Edit or Addition)According to Wikipedia, Rosa Susan Penelope Beddington FRS was a British biologist whose career had a major impact on developmental biology. Education and early life Beddington was born on 23 March 1956, the second daughter of Roy and Anna Beddington . She was raised with her elder sister, Pippa Beddington. She attended Sherborne School for Girls where she not only excelled in academics, but in her arts and sports programs as well. She later attended Brasenose College, Oxford; from 1974, obtaining a First in Physiological Sciences in 1977. Beddington embarked on the study of anterior-posterior axial patterning in mammalian embryos, beginning with her doctoral thesis entitled, "Studies on cell fate and cell potency in the postimplantation mammalian embryo" supervised by Richard Gardner and Virginia Papaioannou, and was awarded a DPhil in 1981.
Rosa Beddington's Published Works
Published Works
- Cbfa1, a Candidate Gene for Cleidocranial Dysplasia Syndrome, Is Essential for Osteoblast Differentiation and Bone Development (1997) (2895)
- Netrin-1 Is Required for Commissural Axon Guidance in the Developing Vertebrate Nervous System (1996) (1269)
- Axis Development and Early Asymmetry in Mammals (1999) (763)
- Manipulating the Mouse Embryo (2007) (717)
- Mutations in the homeobox gene HESX1/Hesx1 associated with septo-optic dysplasia in human and mouse (1998) (714)
- An assessment of the developmental potential of embryonic stem cells in the midgestation mouse embryo. (1989) (591)
- Anterior primitive endoderm may be responsible for patterning the anterior neural plate in the mouse embryo (1996) (577)
- Hex: a homeobox gene revealing peri-implantation asymmetry in the mouse embryo and an early transient marker of endothelial cell precursors. (1998) (549)
- The homeobox gene Hex is required in definitive endodermal tissues for normal forebrain, liver and thyroid formation. (2000) (477)
- Renal agenesis in mice homozygous for a gene trap mutation in the gene encoding heparan sulfate 2-sulfotransferase. (1998) (470)
- Induction of a second neural axis by the mouse node. (1994) (438)
- The transcription factor GATA6 is essential for early extraembryonic development. (1999) (403)
- Mouse Dll3: a novel divergent Delta gene which may complement the function of other Delta homologues during early pattern formation in the mouse embryo. (1997) (396)
- The formation of mesodermal tissues in the mouse embryo during gastrulation and early organogenesis. (1987) (375)
- Wnt signaling in Xenopus embryos inhibits bmp4 expression and activates neural development. (1999) (362)
- Capturing genes encoding membrane and secreted proteins important for mouse development. (1995) (339)
- Anterior patterning in mouse. (1998) (308)
- Heterozygous HESX1 mutations associated with isolated congenital pituitary hypoplasia and septo-optic dysplasia. (2001) (305)
- Cystic fibrosis in the mouse by targeted insertional mutagenesis (1992) (288)
- Growth and Early Postimplantation Defects in Mice Deficient for the Bromodomain-Containing Protein Brd4 (2002) (285)
- Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas (2004) (260)
- The T gene is necessary for normal mesodermal morphogenetic cell movements during gastrulation. (1995) (226)
- Whole-mount in situ hybridization in the mouse embryo: gene expression in three dimensions. (1993) (221)
- Axial skeletal defects caused by mutation in the spondylocostal dysplasia/pudgy gene Dll3 are associated with disruption of the segmentation clock within the presomitic mesoderm. (2002) (219)
- Brachyury--a gene affecting mouse gastrulation and early organogenesis. (1992) (193)
- Cell fate and morphogenetic movement in the late mouse primitive streak (1996) (187)
- The Molecular Phenotype of Heparan Sulfate in theHs2st −/− Mutant Mouse* (2001) (180)
- Active cell migration drives the unilateral movements of the anterior visceral endoderm (2004) (177)
- Msg1 and Mrg1, founding members of a gene family, show distinct patterns of gene expression during mouse embryogenesis (1998) (177)
- Misexpression of Cwnt8C in the mouse induces an ectopic embryonic axis and causes a truncation of the anterior neuroectoderm. (1997) (172)
- Folic acid prevents exencephaly in Cited2 deficient mice. (2002) (164)
- Establishment and organization of germ layers in the gastrulating mouse embryo. (1992) (159)
- An in situ transgenic enzyme marker for the midgestation mouse embryo and the visualization of inner cell mass clones during early organogenesis. (1989) (153)
- Induction and migration of the anterior visceral endoderm is regulated by the extra-embryonic ectoderm (2005) (149)
- An autoradiographic analysis of tissue potency in different regions of the embryonic ectoderm during gastrulation in the mouse. (1982) (148)
- Multi-lineage ‘stem’ cells in the mammalian embryo (1988) (147)
- Molecular effects of novel mutations in Hesx1/HESX1 associated with human pituitary disorders. (2001) (131)
- Expression of inhibin subunits and follistatin during postimplantation mouse development: decidual expression of activin and expression of follistatin in primitive streak, somites and hindbrain. (1994) (130)
- Chimeric analysis of T (Brachyury) gene function. (1993) (125)
- Sp5, a new member of the Sp1 family, is dynamically expressed during development and genetically interacts with Brachyury. (2000) (119)
- BMP-7 influences pattern and growth of the developing hindbrain of mouse embryos. (1997) (115)
- A cell autonomous function of Brachyury in T/T embryonic stem cell chimaeras (1991) (112)
- Hex is a transcriptional repressor that contributes to anterior identity and suppresses Spemann organiser function. (2000) (107)
- The homeobox gene Hesx1 is required in the anterior neural ectoderm for normal forebrain formation. (2000) (106)
- Distinct enhancer elements control Hex expression during gastrulation and early organogenesis. (2001) (99)
- An anterior signalling centre in Xenopus revealed by the homeobox gene XHex (1999) (96)
- The transcription factor GATA6 is essential for early extraembryonic development. (1999) (87)
- Expression of T protein in the primitive streak is necessary and sufficient for posterior mesoderm movement and somite differentiation. (1997) (85)
- The role of the brachyury gene in heart development and left–right specification in the mouse (1998) (85)
- Cited1 Is Required in Trophoblasts for Placental Development and for Embryo Growth and Survival (2004) (82)
- Control of vertebrate gastrulation: inducing signals and responding genes. (1993) (80)
- Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. (1995) (70)
- Targeted deletion of the novel cytoplasmic dynein mD2LIC disrupts the embryonic organiser, formation of the body axes and specification of ventral cell fates (2004) (67)
- Histogenetic and neoplastic potential of different regions of the mouse embryonic egg cylinder. (1983) (66)
- The origin of the foetal tissues during gastrulation in the rodent (1983) (64)
- Foregut endoderm is required at head process stages for anteriormost neural patterning in chick. (2001) (60)
- Principles of Development, 2nd Edition (2002) (60)
- Getting your head around Hex and Hesx1: forebrain formation in mouse. (2001) (54)
- Dll3 pudgy mutation differentially disrupts dynamic expression of somite genes (2004) (51)
- Alterations in gene expression during mesoderm formation and axial patterning in Brachyury (T) embryos. (1994) (45)
- Permissiveness to murine leukemia, virus expression during preimplantation and early postimplantation mouse development. (1989) (43)
- Axis duplication and anterior identity in the mouse embryo. (1997) (42)
- Development of chick axial mesoderm: specification of prechordal mesoderm by anterior endoderm-derived TGFbeta family signalling. (2000) (38)
- The Metameric Organization of the Presomitic Mesoderm and Somite Specification in the Mouse Embryo (1986) (37)
- Molecular Genetics of Septo-Optic Dysplasia (2000) (33)
- Expression of v-src induces aberrant development and twinning in chimaeric mice. (1991) (32)
- The embryonic RNA helicase gene (ERH): a new member of the DEAD box family of RNA helicases. (1995) (31)
- Diverse requirements for Notch signalling in mammals. (2002) (31)
- T promoter activity in the absence of functional T protein during axis formation and elongation in the mouse. (1997) (29)
- Characterizing embryonic gene expression patterns in the mouse using nonredundant sequence-based selection. (2003) (27)
- An in situ transgenic enzyme marker to monitor migration of cells in the mid-gestation mouse embryo. Somite contribution to the early forelimb bud. (1989) (26)
- The expression of the imprinted gene Ipl is restricted to extra-embryonic tissues and embryonic lateral mesoderm during early mouse development. (2002) (24)
- Experimental approaches to mammalian embryonic development: Analysis of tissue fate and prospective potency in the egg cylinder (1987) (23)
- A radiation hybrid transcript map of the mouse genome (2001) (22)
- Use of chimeras to study gene function in mesodermal tissues during gastrulation and early organogenesis. (2007) (20)
- Detection of mRNA in whole mounts of mouse embryos using digoxigenin riboprobes. (1994) (17)
- Mouse gastrulation from a frog's perspective (1995) (16)
- Isolation of developmentally regulated genes by differential display screening of cDNA libraries. (1998) (14)
- The development of 12th to 14th day foetuses following reimplantation of pre- and early-primitive-streak-stage mouse embryos. (1985) (13)
- Cell surface proteoglycans in signalling and development (1999) (12)
- Left, right, left... turn (1996) (12)
- Toxigenics: strategic cell death in the embryo. (1988) (9)
- Developmental biology: Cripto-analysis of embryonic codes (1998) (9)
- Genetic mapping and embryonic expression of a novel, maternally transcribed gene Mem3 (1996) (8)
- Mouse mutagenesis: From gene to phenotype and back again (1998) (7)
- Transgenic mutagenesis in the mouse. (1992) (7)
- Transgenic strategies in mouse embryology and development. (1992) (6)
- The Analysis of Cell Lineages in the Postimplantation Mammalian Embryo (1982) (4)
- Erratum: A radiation hybrid transcript map of the mouse genome (Nature Genetics (2001) 29 (194-200)) (2001) (4)
- Opinions on left-right axis formation. (1995) (3)
- Pattern formation and developmental mechanisms. (1994) (2)
- The identification of novel sequences expressed in the mouse notochord (2009) (2)
- Teaching the Essential Principles of Development (2003) (1)
- Seaside signal success (1996) (1)
- 37 Axon guidance by diffusible attract ants and repellents (1996) (0)
- ARY T gene is necessary for normal ements during gastrulation (1995) (0)
- Topobiology: an introduction to molecular embryology: Gerald E. Edelman, Basic Books, 1988. $21.95 (xv + 240 pages) ISBN 0 465 08634 9 (1989) (0)
- Abstracts of papers presented at the 1996 Meeting on Mouse Molecular Genetics, August 28-September 1, 1996 (1996) (0)
- From Egg embryo (2nd edn): by J.M.W. Slack Cambridge University Press, 1991. £45.00/$75.00 hbk, £16.95/$32.50 pbk (xix + 328 pages) ISBN 0 521 40108 (1992) (0)
- Cellular and Molecular Aspects of Implantation, S.R. Glasser, D.W. Bullock (Eds.). Plenum Press, London (1981), ISBN: 0-306-40581-4 (1982) (0)
- Opinions on left-right axis formation. Author's reply (1995) (0)
- Hex in forebrain, liver and thyroid formation (2000) (0)
- Mammalian Embryo: Establishment of the Embryonic Axes (2001) (0)
- Abstracts of papers presented at the 1998 Meeting on Mouse Molecular Genetics, September 2-September 6, 1998 (1998) (0)
- Use of embryonic stem-cells for creating a CF mouse model (1992) (0)
- A loss-of-function mutation in the mouse delta-like3 (Dll3) (2002) (0)
- Transgenic LacZ as a marker for cell lineage analysis during mouse embryogenesis. (1990) (0)
- The atlas of mouse development (1993) (0)
- O-077 Dynamic events during the specification of the anterior–posterior axis Session – Law and ethics in ART (2005) (0)
- Axis Development and Early Review Asymmetry in Mammals (1999) (0)
- Pattern formation and developmental mechanisms. (1997) (0)
- Structure and bioactivity of heparan sulphate from the 2-O-sulphotransferase mutant mouse (2001) (0)
- Opinions on left-right axis formation [letter; comment] (1995) (0)
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