Rudi Beyaert
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Engineering Computer Science
Rudi Beyaert's Degrees
- Masters Electrical Engineering Stanford University
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(Suggest an Edit or Addition)Rudi Beyaert's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation. (1992) (962)
- Inhibition of Caspases Increases the Sensitivity of L929 Cells to Necrosis Mediated by Tumor Necrosis Factor (1998) (900)
- More than one way to die: apoptosis, necrosis and reactive oxygen damage (1999) (893)
- Two tumour necrosis factor receptors: structure and function. (1995) (814)
- Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 (2021) (811)
- The p38/RK mitogen‐activated protein kinase pathway regulates interleukin‐6 synthesis response to tumor necrosis factor. (1996) (708)
- Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition) (2019) (627)
- Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene‐inductive effects of TNF. (1993) (579)
- Functional diversity and regulation of different interleukin-1 receptor-associated kinase (IRAK) family members. (2003) (566)
- Role of Toll-Like Receptors in Pathogen Recognition (2003) (554)
- Inhibition of Interleukin 1 Receptor/Toll-like Receptor Signaling through the Alternatively Spliced, Short Form of MyD88 Is Due to Its Failure to Recruit IRAK-4 (2003) (541)
- The ubiquitin-editing enzyme A20 (TNFAIP3) is a central regulator of immunopathology. (2009) (475)
- Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells (2015) (465)
- Limiting inflammation—the negative regulation of NF-κB and the NLRP3 inflammasome (2017) (438)
- Yolk Sac Macrophages, Fetal Liver, and Adult Monocytes Can Colonize an Empty Niche and Develop into Functional Tissue-Resident Macrophages. (2016) (426)
- Interleukin-1α controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33 (2012) (404)
- TLR-4, IL-1R and TNF-R signaling to NF-κB: variations on a common theme (2008) (399)
- Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis (2014) (386)
- A universal role for MyD88 in TLR/IL-1R-mediated signaling. (2002) (384)
- T cell antigen receptor stimulation induces MALT1 paracaspase–mediated cleavage of the NF-κB inhibitor A20 (2008) (380)
- A20 in inflammation and autoimmunity. (2014) (350)
- Proteolytic Processing of Interleukin-1 Family Cytokines: Variations on a Common Theme. (2015) (348)
- Stimulation of Toll-like receptor 3 and 4 induces interleukin-1β maturation by caspase-8 (2008) (324)
- Identification and characterization of a novel cell cycle-regulated internal ribosome entry site. (2000) (316)
- Non‐specific effects of methyl ketone peptide inhibitors of caspases (1999) (316)
- A20 and A20-binding proteins as cellular inhibitors of nuclear factor-kappa B-dependent gene expression and apoptosis. (2000) (315)
- Sensing of Viral Infection and Activation of Innate Immunity by Toll-Like Receptor 3 (2008) (299)
- Regulation of Interleukin-1- and Lipopolysaccharide-Induced NF-κB Activation by Alternative Splicing of MyD88 (2002) (297)
- A20: Central Gatekeeper in Inflammation and Immunity* (2009) (290)
- The Zinc Finger Protein A20 Inhibits TNF-induced NF-κB–dependent Gene Expression by Interfering with an RIP- or TRAF2-mediated Transactivation Signal and Directly Binds to a Novel NF-κB–inhibiting Protein ABIN (1999) (284)
- Enterocyte-specific A20 deficiency sensitizes to tumor necrosis factor–induced toxicity and experimental colitis (2010) (275)
- A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis (2011) (264)
- Molecular mechanisms of tumor necrosis factor‐induced cytotoxicity (1994) (257)
- Cell death induction by receptors of the TNF family: towards a molecular understanding (1997) (252)
- A20 inhibits NF-κB activation by dual ubiquitin-editing functions (2005) (251)
- Perinatal Activation of the Interleukin-33 Pathway Promotes Type 2 Immunity in the Developing Lung. (2016) (240)
- The ubiquitin-editing protein A20 prevents dendritic cell activation, recognition of apoptotic cells, and systemic autoimmunity. (2011) (231)
- Are the IKKs and IKK-related kinases TBK1 and IKK-epsilon similarly activated? (2008) (224)
- Ubiquitin binding mediates the NF-κB inhibitory potential of ABIN proteins (2008) (221)
- Hepatic tumor necrosis factor signaling and nuclear factor-kappaB: effects on liver homeostasis and beyond. (2007) (220)
- Characterization of seven murine caspase family members (1997) (209)
- Mechanisms of crosstalk between TNF-induced NF-kappaB and JNK activation in hepatocytes. (2006) (205)
- MicroRNA let-7 modulates the immune response to Mycobacterium tuberculosis infection via control of A20, an inhibitor of the NF-κB pathway. (2015) (204)
- MyD88S, a splice variant of MyD88, differentially modulates NF‐κB‐ and AP‐1‐dependent gene expression (2003) (196)
- T‐cell receptor‐induced JNK activation requires proteolytic inactivation of CYLD by MALT1 (2011) (193)
- A20 inhibits LUBAC‐mediated NF‐κB activation by binding linear polyubiquitin chains via its zinc finger 7 (2012) (193)
- The cytokine‐inducible zinc finger protein A20 inhibits IL‐1‐induced NF‐κB activation at the level of TRAF6 (1999) (191)
- B cells lacking the tumor suppressor TNFAIP3/A20 display impaired differentiation and hyperactivation and cause inflammation and autoimmunity in aged mice. (2011) (178)
- Expression, biological activities and mechanisms of action of A20 (TNFAIP3). (2010) (176)
- A Novel Type of Deubiquitinating Enzyme* (2003) (172)
- Neu1 desialylation of sialyl alpha-2,3-linked beta-galactosyl residues of TOLL-like receptor 4 is essential for receptor activation and cellular signaling. (2010) (171)
- ABINs: A20 binding inhibitors of NF-kappa B and apoptosis signaling. (2009) (167)
- CYLD, A20 and OTULIN deubiquitinases in NF-κB signaling and cell death: so similar, yet so different (2017) (166)
- The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock (2012) (165)
- Targeting Rac1 by the Yersinia Effector Protein YopE Inhibits Caspase-1-mediated Maturation and Release of Interleukin-1β* (2004) (164)
- Tumour necrosis factor-induced necrosis versus anti-Fas-induced apoptosis in L929 cells. (1997) (160)
- Inflammatory cardiac valvulitis in TAX1BP1‐deficient mice through selective NF‐κB activation (2008) (153)
- Patterns, Receptors, and Signals: Regulation of Phagosome Maturation (2017) (153)
- The S. Typhimurium effector SopE induces caspase-1 activation in stromal cells to initiate gut inflammation. (2009) (152)
- Yeast Two-Hybrid: State of the Art (1999) (152)
- Cathepsin B-mediated activation of the proinflammatory caspase-11. (1998) (149)
- The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases (1999) (147)
- Translational control of eukaryotic gene expression (2009) (141)
- Cleavage of PITSLRE Kinases by ICE/CASP-1 and CPP32/CASP-3 during Apoptosis Induced by Tumor Necrosis Factor* (1997) (141)
- Caspase-11 Gene Expression in Response to Lipopolysaccharide and Interferon-γ Requires Nuclear Factor-κB and Signal Transducer and Activator of Transcription (STAT) 1* (2002) (138)
- Tumor necrosis factor and lymphotoxin (1998) (133)
- Toll-like Receptor 4 Engagement on Dendritic Cells Restrains Phago-Lysosome Fusion and Promotes Cross-Presentation of Antigens. (2015) (133)
- TRAF2 multitasking in TNF receptor-induced signaling to NF-κB, MAP kinases and cell death. (2016) (131)
- Enterocyte death and intestinal barrier maintenance in homeostasis and disease. (2011) (130)
- Interleukin-21-Producing CD4(+) T Cells Promote Type 2 Immunity to House Dust Mites. (2015) (128)
- Up-regulation of MyD88s and SIGIRR, molecules inhibiting Toll-like receptor signaling, in monocytes from septic patients* (2006) (127)
- The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages (2016) (119)
- Dependence of pathogen molecule-induced Toll-like receptor activation and cell function on Neu1 sialidase (2009) (119)
- Pellino proteins are more than scaffold proteins in TLR/IL‐1R signalling: A role as novel RING E3–ubiquitin‐ligases (2006) (117)
- A20 inhibits NF-kappaB activation by dual ubiquitin-editing functions. (2005) (116)
- Nuclear factor kappa B (NF-κB) in multiple sclerosis pathology. (2013) (115)
- Function and regulation of tumor necrosis factor receptor type 2. (2004) (114)
- Abscisic Acid as Pathogen Effector and Immune Regulator (2017) (113)
- Effect of bcl-2 proto-oncogene expression on cellular sensitivity to tumor necrosis factor-mediated cytotoxicity. (1993) (113)
- Non-apoptotic functions of caspase-8. (2008) (112)
- TNF-induced intracellular signaling leading to gene induction or to cytotoxicity by necrosis or by apoptosis. (1995) (111)
- Reduced tumour necrosis factor-induced cytotoxicity by inhibitors of the arachidonic acid metabolism. (1987) (110)
- A role for hnRNP C1/C2 and Unr in internal initiation of translation during mitosis (2007) (108)
- Identification of a Novel A20-binding Inhibitor of Nuclear Factor-κB Activation Termed ABIN-2* (2001) (107)
- Structure–function analysis of the A20‐binding inhibitor of NF‐κB activation, ABIN‐1 (2003) (105)
- Cancer risk in immune-mediated inflammatory diseases (IMID) (2013) (104)
- A20 controls intestinal homeostasis through cell-specific activities (2014) (103)
- Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma (2017) (102)
- Structure and Function of the Type III Secretion System of Pseudomonas aeruginosa (2012) (98)
- Pellino Proteins: Novel Players in TLR and IL-1R Signalling (2007) (96)
- Genetic relationships between A20/TNFAIP3, chronic inflammation and autoimmune disease. (2011) (96)
- Emerging Role of Ubiquitination in Antiviral RIG-I Signaling (2012) (94)
- The polypyrimidine tract-binding protein stimulates HIF-1α IRES-mediated translation during hypoxia (2005) (94)
- The IL‐33/ST2 axis is crucial in type 2 airway responses induced by Staphylococcus aureus–derived serine protease–like protein D (2017) (92)
- Lithium chloride potentiates tumor necrosis factor-mediated cytotoxicity in vitro and in vivo. (1989) (87)
- Regulation of NF-κB signaling by caspases and MALT1 paracaspase (2011) (85)
- IκB kinase ɛ (IKKɛ): A therapeutic target in inflammation and cancer (2013) (85)
- Nuclear Factor кB (2003) (84)
- Keratinocyte-specific ablation of the NF-κB regulatory protein A20 (TNFAIP3) reveals a role in the control of epidermal homeostasis (2011) (81)
- Tumour-necrosis-factor-mediated cytotoxicity is correlated with phospholipase-A2 activity, but not with arachidonic acid release per se. (1991) (80)
- Crosstalk between NF-kappaB-activating and apoptosis-inducing proteins of the TNF-receptor complex. (2001) (79)
- LIND/ABIN-3 Is a Novel Lipopolysaccharide-inducible Inhibitor of NF-κB Activation* (2007) (78)
- A Novel TRAF6 Binding Site in MALT1 Defines Distinct Mechanisms of NF-κB Activation by API2·MALT1 Fusions* (2007) (77)
- A20 (Tnfaip3) Deficiency in Myeloid Cells Protects against Influenza A Virus Infection (2012) (77)
- Neu1 Sialidase and Matrix Metalloproteinase-9 Cross-talk Is Essential for Toll-like Receptor Activation and Cellular Signaling* (2011) (76)
- UNR translation can be driven by an IRES element that is negatively regulated by polypyrimidine tract binding protein (2005) (76)
- Isolation and characterization of two novel A20-like proteins. (2001) (75)
- Regulation of the cell-cycle-dependent internal ribosome entry site of the PITSLRE protein kinase: roles of Unr (upstream of N-ras) protein and phosphorylated translation initiation factor eIF-2α (2005) (75)
- Casein Kinase-1 Phosphorylates the p75 Tumor Necrosis Factor Receptor and Negatively Regulates Tumor Necrosis Factor Signaling for Apoptosis (*) (1995) (75)
- TRAF1 is a TNF inducible regulator of NF‐κB activation (1999) (73)
- Functional redundancy of the zinc fingers of A20 for inhibition of NF‐κB activation and protein–protein interactions (2001) (72)
- Negative regulation of NF-κB and its involvement in rheumatoid arthritis (2011) (72)
- The tumor necrosis factor alpha-induced protein 3 (TNFAIP3, A20) imposes a brake on antitumor activity of CD8 T cells (2014) (69)
- Attenuated Expression of A20 Markedly Increases the Efficacy of Double-Stranded RNA-Activated Dendritic Cells As an Anti-Cancer Vaccine1 (2009) (68)
- Molecular mechanisms of IL-33-mediated stromal interactions in cancer metastasis. (2018) (67)
- MALT1 – a universal soldier: multiple strategies to ensure NF‐κB activation and target gene expression (2015) (67)
- Pharmacological inhibition of MALT1 protease activity protects mice in a mouse model of multiple sclerosis (2014) (66)
- Involvement of a serine protease in tumour-necrosis-factor-mediated cytotoxicity. (1988) (66)
- IL-33 targeting attenuates intestinal mucositis and enhances effective tumour chemotherapy in mice (2014) (65)
- Dominant-negative mutations in human IL6ST underlie hyper-IgE syndrome (2020) (64)
- Antiinflammatory properties of a plant-derived nonsteroidal, dissociated glucocorticoid receptor modulator in experimental autoimmune encephalomyelitis. (2010) (63)
- Enhanced osteoclast development in collagen-induced arthritis in interferon-γ receptor knock-out mice as related to increased splenic CD11b+ myelopoiesis (2004) (62)
- Paracaspase MALT1 Deficiency Protects Mice from Autoimmune-Mediated Demyelination (2013) (61)
- A20-Deficient Mast Cells Exacerbate Inflammatory Responses In Vivo (2014) (61)
- Death receptor signalling in central nervous system inflammation and demyelination (2011) (60)
- MALT1 cleaves the E3 ubiquitin ligase HOIL‐1 in activated T cells, generating a dominant negative inhibitor of LUBAC‐induced NF‐κB signaling (2016) (59)
- The paracaspase MALT1 mediates CARD14‐induced signaling in keratinocytes (2016) (59)
- Optineurin deficiency in mice is associated with increased sensitivity to Salmonella but does not affect proinflammatory NF‐κB signaling (2016) (58)
- TAX1BP1, a ubiquitin-binding adaptor protein in innate immunity and beyond. (2011) (57)
- TRAF2 plays a dual role in NF‐κB‐dependent gene activation by mediating the TNF‐induced activation of p38 MAPK and IκB kinase pathways (1998) (57)
- Ubiquitin: tool and target for intracellular NF-κB inhibitors (2006) (56)
- Identification of Interaction Sites for Dimerization and Adapter Recruitment in Toll/Interleukin-1 Receptor (TIR) Domain of Toll-like Receptor 4* (2011) (56)
- Endoplasmic reticulum chaperone gp96 is essential for infection with vesicular stomatitis virus (2010) (55)
- Oligodendrocyte-Specific FADD Deletion Protects Mice from Autoimmune-Mediated Demyelination (2010) (55)
- Regulation of TNF-induced NF-κB activation by different cytoplasmic ubiquitination events. (2011) (54)
- Two discrete types of tumor necrosis factor-resistant cells derived from the same cell line. (1991) (53)
- Signaling to gene activation and cell death by tumor necrosis factor receptors and Fas. (2002) (53)
- A20 inhibition of STAT1 expression in myeloid cells: a novel endogenous regulatory mechanism preventing development of enthesitis (2016) (53)
- Reversion of autoimmune lymphoproliferative syndrome with an antimalarial drug: preliminary results of a clinical cohort study and molecular observations (2002) (52)
- Nuclear factor-kappa B plays a central role in tumour necrosis factor-mediated liver disease. (2003) (52)
- Cleavage of caspase family members by granzyme B: a comparative study in vitro (1997) (52)
- A20 prevents chronic liver inflammation and cancer by protecting hepatocytes from death (2016) (51)
- Targeting MALT1 Proteolytic Activity in Immunity, Inflammation and Disease: Good or Bad? (2016) (51)
- Inflammation and NF-κB Signaling in Prostate Cancer: Mechanisms and Clinical Implications (2018) (50)
- The Cathepsin B Inhibitor z-FA.fmk Inhibits Cytokine Production in Macrophages Stimulated by Lipopolysaccharide* (2001) (49)
- The multifaceted role of the E3 ubiquitin ligase HOIL‐1: beyond linear ubiquitination (2015) (49)
- Classification and Nomenclature of Metacaspases and Paracaspases: No More Confusion with Caspases. (2020) (49)
- Regulation of the cell-cycle-dependent internal ribosome entry site of the PITSLRE protein kinase: roles of Unr (upstream of N-ras) protein and phosphorylated translation initiation factor eIF-2alpha. (2005) (48)
- Receptor proximal kinases in NF-κB signaling as potential therapeutic targets in cancer and inflammation. (2014) (47)
- Adenoviral gene transfer of ABIN‐1 protects mice from TNF/galactosamine‐induced acute liver failure and lethality (2005) (47)
- A20, an inhibitor of cell death, self‐associates by its zinc finger domain (1996) (46)
- Structure-function analysis of the A20-binding inhibitor of NF-kappa B activation, ABIN-1. (2003) (46)
- Glucocorticoid receptor dimers control intestinal STAT1 and TNF-induced inflammation in mice (2018) (45)
- TRAF1 is a TNF inducible regulator of NF-kappaB activation. (1999) (45)
- A20 Deficiency in Lung Epithelial Cells Protects against Influenza A Virus Infection (2016) (44)
- The Pseudomonas aeruginosa Type III Secretion System Has an Exotoxin S/T/Y Independent Pathogenic Role during Acute Lung Infection (2012) (44)
- Sensitization of tnf-induced apoptosis with polyamine synthesis inhibitors in different human and murine tumour cell lines. (1998) (43)
- Structure-Activity Relationship in Monosaccharide-Based Toll-Like Receptor 4 (TLR4) Antagonists. (2018) (43)
- Inflammatory cell-derived CXCL3 promotes pancreatic cancer metastasis through a novel myofibroblast-hijacked cancer escape mechanism (2021) (42)
- The influence of age and repeated lipopolysaccharide administration on body temperature and the concentration of interleukin-6 and IgM antibodies against lipopolysaccharide in broiler chickens (2008) (42)
- A20 Inhibits NF-κB Activation Independently of Binding to 14-3-3 Proteins (1997) (41)
- Characterization of an intravenous lipopolysaccharide inflammation model in broiler chickens (2009) (40)
- Differential activation of phospholipases during necrosis or apoptosis: A comparative study using tumor necrosis factor and anti‐Fas antibodies (1998) (39)
- TIM3+ TRBV11-2 T cells and IFNγ signature in patrolling monocytes and CD16+ NK cells delineate MIS-C (2021) (39)
- Functional Characterization of the Prodomain of Interleukin1β-converting Enzyme* (1996) (39)
- In Macrophages, Caspase-1 Activation by SopE and the Type III Secretion System-1 of S. Typhimurium Can Proceed in the Absence of Flagellin (2010) (38)
- Differential involvement of caspases in apoptosis of myeloid leukemic cells induced by chemotherapy versus growth factor withdrawal (1997) (38)
- IL-33trap is a novel IL-33-neutralizing biologic that inhibits allergic airway inflammation. (2019) (37)
- Adenoviral Gene Transfer of the NF-κB Inhibitory Protein ABIN-1 Decreases Allergic Airway Inflammation in a Murine Asthma Model* (2005) (37)
- Enhancement of tumor necrosis factor cytotoxicity by lithium chloride is associated with increased inositol phosphate accumulation. (1993) (36)
- Inhibition of tumor necrosis factor-induced necrotic cell death by the zinc finger protein A20. (1999) (35)
- Ubiquitin: tool and target for intracellular NF-kappaB inhibitors. (2006) (35)
- Two distinct ubiquitin-binding motifs in A20 mediate its anti-inflammatory and cell-protective activities (2020) (35)
- MAPPIT analysis of TLR adaptor complexes (2007) (34)
- Dichotomous function of IL‐33 in health and disease: From biology to clinical implications (2018) (34)
- A CARD9 Founder Mutation Disrupts NF-κB Signaling by Inhibiting BCL10 and MALT1 Recruitment and Signalosome Formation (2018) (33)
- Synergistic induction of interleukin‐6 by tumor necrosis factor and lithium chloride in mice: Possible role in the triggering and exacerbation of psoriasis by lithium treatment (1992) (33)
- Apoptosis of hematopoietic cells induced by growth factor withdrawal is associated with caspase-9 mediated cleavage of Raf-1 (2005) (32)
- The Zinc Finger Protein A 20 Inhibits TNF-induced NFk B – dependent Gene Expression by Interfering with an RIP-or TRAF 2-mediated Transactivation Signal and Directly Binds to a Novel NFk B – inhibiting Protein (1999) (32)
- Thymoquinone-induced Neu4 sialidase activates NFκB in macrophage cells and pro-inflammatory cytokines in vivo (2010) (31)
- Tumor necrosis factor cytotoxicity is associated with phospholipase D activation. (1993) (30)
- The Biology of A20-Binding Inhibitors of NF-κB Activation (ABINS) (2014) (30)
- TNFα- and IKKβ-mediated TANK/I-TRAF phosphorylation: implications for interaction with NEMO/IKKγ and NF-κB activation (2006) (30)
- Polo-like kinase 1 (PLK1) signaling in cancer and beyond. (2021) (30)
- MALT1 Proteolytic Activity Suppresses Autoimmunity in a T Cell Intrinsic Manner (2019) (30)
- NKT sublineage specification and survival requires the ubiquitin-modifying enzyme TNFAIP3/A20 (2016) (29)
- Thymoquinone from nutraceutical black cumin oil activates Neu4 sialidase in live macrophage, dendritic, and normal and type I sialidosis human fibroblast cells via GPCR Gαi proteins and matrix metalloproteinase-9 (2010) (29)
- CARD14-Mediated Activation of Paracaspase MALT1 in Keratinocytes: Implications for Psoriasis. (2017) (29)
- Cleavage by MALT1 induces cytosolic release of A20. (2010) (29)
- Inhibition by glucocorticoids of tumor necrosis factor‐mediated cytotoxicity (1990) (29)
- ABINs inhibit EGF receptor-mediated NF-κB activation and growth of EGF receptor-overexpressing tumour cells (2008) (29)
- Lithium chloride potentiates tumor necrosis factor-induced and interleukin 1-induced cytokine and cytokine receptor expression. (1991) (28)
- TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile (2019) (28)
- IL‐33 signalling contributes to pollutant‐induced allergic airway inflammation (2018) (28)
- Ubiquitination and phosphorylation of the CARD11-BCL10-MALT1 signalosome in T cells. (2019) (27)
- Ancient Origin of the CARD–Coiled Coil/Bcl10/MALT1-Like Paracaspase Signaling Complex Indicates Unknown Critical Functions (2018) (27)
- MALT1 is not alone after all: identification of novel paracaspases (2016) (27)
- Inflammatory Properties and Adjuvant Potential of Synthetic Glycolipids Homologous to Mycolate Esters of the Cell Wall of Mycobacterium tuberculosis (2016) (26)
- Sensitization of tumor cells to tumor necrosis factor action by the protein kinase inhibitor staurosporine. (1993) (26)
- A human immune dysregulation syndrome characterized by severe hyperinflammation with a homozygous nonsense Roquin-1 mutation (2019) (26)
- Caspase-1 targets the TLR adaptor Mal at a crucial TIR-domain interaction site (2010) (25)
- A Novel TRAF6 binding site in MALT1 defines distinct mechanisms of NF-kappaB activation by API2middle dotMALT1 fusions. (2007) (25)
- A20 Restrains Thymic Regulatory T Cell Development (2017) (25)
- A20 Inhibits β-Cell Apoptosis by Multiple Mechanisms and Predicts Residual β-Cell Function in Type 1 Diabetes. (2016) (25)
- Regulation of Macrophage Motility by the Water Channel Aquaporin-1: Crucial Role of M0/M2 Phenotype Switch (2015) (25)
- TNF in combination with interferon-gamma is cytotoxic to normal, untransformed mouse and rat embryo fibroblast-like cells. (1989) (25)
- Expression of the NF-κB inhibitor ABIN-3 in response to TNF and toll-like receptor 4 stimulation is itself regulated by NF-κB (2007) (25)
- TRAF2 plays a dual role in NF-kappaB-dependent gene activation by mediating the TNF-induced activation of p38 MAPK and IkappaB kinase pathways. (1998) (24)
- Alzheimer's Disease Associated Presenilin 1 Interacts with HC5 and ZETA, Subunits of the Catalytic 20S Proteasome (1999) (24)
- Dexamethasone alters messenger RNA levels but not synthesis of collagens, fibronectin, or laminin by cultured rat fat‐storing cells (1996) (24)
- Hormone sensitivity in vitro and in vivo of v‐ras‐transfected mcf‐7 cell derivatives (1990) (23)
- Pharmacodynamics of tepoxalin, sodium-salicylate and ketoprofen in an intravenous lipopolysaccharide inflammation model in broiler chickens. (2010) (23)
- Caspase‐11 mediates ischemia‐induced astrocyte death: Involvement of endoplasmic reticulum stress and C/EBP homologous protein (2009) (23)
- A20 and CYLD Do Not Share Significant Overlapping Functions during B Cell Development and Activation (2012) (23)
- The biology of A20-binding inhibitors of NF-kappaB activation (ABINs). (2014) (22)
- Unusual Lipid A from a Cold‐Adapted Bacterium: Detailed Structural Characterization (2017) (22)
- Immune responses and therapeutic options in psoriasis (2021) (22)
- Isolation and characterization of two novel A20-like proteins (2001) (21)
- Novel carboxylate-based glycolipids: TLR4 antagonism, MD-2 binding and self-assembly properties (2019) (21)
- Differential role of calcium in tumour necrosis factor-mediated apoptosis and secretion of granulocyte-macrophage colony-stimulating factor in a T cell hybridoma. (1997) (21)
- The E3 ubiquitin ligases HOIP and cIAP1 are recruited to the TNFR2 signaling complex and mediate TNFR2‐induced canonical NF‐&kgr;B signaling (2018) (21)
- ST2 as checkpoint target for colorectal cancer immunotherapy. (2020) (21)
- MALT1-Deficient Mice Develop Atopic-Like Dermatitis Upon Aging (2019) (21)
- Linear ubiquitination in NF-κB signaling and inflammation: What we do understand and what we do not. (2011) (20)
- Development of αGlcN(1↔1)αMan-Based Lipid A Mimetics as a Novel Class of Potent Toll-like Receptor 4 Agonists (2014) (19)
- Nuclear factor kB: Regulation and role in disease (2003) (19)
- Impact of caspase-1/11, -3, -7, or IL-1β/IL-18 deficiency on rabies virus-induced macrophage cell death and onset of disease (2017) (18)
- Chemical Synthesis of Burkholderia Lipid A Modified with Glycosyl Phosphodiester-Linked 4-Amino-4-deoxy-β-l-arabinose and Its Immunomodulatory Potential (2015) (18)
- The kinase NIK as a therapeutic target in multiple myeloma (2011) (17)
- Smurf2 is a TRAF2 binding protein that triggers TNF-R2 ubiquitination and TNF-R2-induced JNK activation. (2008) (17)
- Disaccharide‐Based Anionic Amphiphiles as Potent Inhibitors of Lipopolysaccharide‐Induced Inflammation (2018) (16)
- TNFalpha- and IKKbeta-mediated TANK/I-TRAF phosphorylation: implications for interaction with NEMO/IKKgamma and NF-kappaB activation. (2006) (16)
- IL-17 Signaling Triggers Degradation of the Constitutive NF-κB Inhibitor ABIN-1 (2017) (15)
- Functional requirement of the two TNF receptors for induction of apoptosis in PC60 cells and the role of mitochondria in TNF-induced cytotoxicity. (1994) (14)
- MALT1 Controls Attenuated Rabies Virus by Inducing Early Inflammation and T Cell Activation in the Brain (2018) (14)
- Induction of inflammatory cell infiltration and necrosis in normal mouse skin by the combined treatment of tumor necrosis factor and lithium chloride. (1991) (14)
- A20: attractive without showing cleavage (2014) (14)
- High-fat nutrition reduces hepatic damage following exposure to bacterial DNA and hemorrhagic shock. (2009) (14)
- Mepazine Inhibits RANK-Induced Osteoclastogenesis Independent of Its MALT1 Inhibitory Function (2018) (14)
- T-cell receptor-induced JNK activation requires proteolytic inactivation of CYLD by MALT 1 (2011) (14)
- NF-κB activation by tumor necrosis factor and interleukin-1 (2003) (14)
- A screening assay for Selective Dimerizing Glucocorticoid Receptor Agonists and Modulators (SEDIGRAM) that are effective against acute inflammation (2018) (13)
- XEDAR activates the non-canonical NF-κB pathway. (2015) (13)
- A20 deficiency sensitizes pancreatic beta cells to cytokine-induced apoptosis in vitro but does not influence type 1 diabetes development in vivo (2015) (13)
- Importance of Validating Antibodies and Small Compound Inhibitors Using Genetic Knockout Studies—T Cell Receptor-Induced CYLD Phosphorylation by IKKε/TBK1 as a Case Study (2018) (13)
- MAPPIT (mammalian protein-protein interaction trap) analysis of early steps in toll-like receptor signalling. (2009) (13)
- Defining the combinatorial space of PKC::CARD‐CC signal transduction nodes (2020) (12)
- Engineering a minimal cloning vector from a pUC18 plasmid backbone with an extended multiple cloning site. (2019) (12)
- Anti-endotoxic activity and structural basis for human MD-2·TLR4 antagonism of tetraacylated lipid A mimetics based on βGlcN(1↔1)αGlcN scaffold (2015) (12)
- Use of the yeast three-hybrid system as a tool to study caspases. (1998) (12)
- Cytotoxic activity of tumor necrosis factor is inhibited by amiloride derivatives without involvement of the Na+/H+ antiporter (1990) (12)
- MALT1 targeting suppresses CARD14‐induced psoriatic dermatitis in mice (2020) (12)
- IL-5-producing CD4+ T cells and eosinophils cooperate to enhance response to immune checkpoint blockade in breast cancer. (2022) (12)
- 99mTc-labelled S-HYNIC certolizumab pegol in rheumatoid arthritis and spondyloarthritis patients: a biodistribution and dosimetry study (2016) (11)
- A 20 ( Tnfaip 3 ) Deficiency in Myeloid Cells Protects against Influenza A Virus Infection (2012) (11)
- Spatiotemporal Changes of the Phagosomal Proteome in Dendritic Cells in Response to LPS Stimulation* (2019) (11)
- SHP works a double shift to control TLR signaling (2011) (11)
- Gene cloning and structure--function relationship of cytokines such as TNF and interleukins. (1987) (11)
- Bidirectional Crosstalk Between Hypoxia Inducible Factors and Glucocorticoid Signalling in Health and Disease (2021) (11)
- Phytohormones: Multifunctional nutraceuticals against metabolic syndrome and comorbid diseases. (2020) (11)
- Yeast two-hybrid screening for proteins interacting with the anti-apoptotic protein A20. (2004) (11)
- Long-Term MALT1 Inhibition in Adult Mice Without Severe Systemic Autoimmunity (2020) (10)
- A20 inhibits NF-kappaB activation independently of binding to 14-3-3 proteins. (1997) (10)
- The p110 delta isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock (vol 13, pg 1045, 2012) (2013) (9)
- Inhibition of MALT1 Decreases Neuroinflammation and Pathogenicity of Virulent Rabies Virus in Mice (2018) (9)
- Potentiation of tumour necrosis factor-mediated activities by lithium salts: a review (1992) (9)
- Zinc inhibits lethal inflammatory shock by preventing microbe‐induced interferon signature in intestinal epithelium (2020) (9)
- Cyclin D2 overexpression drives B1a-derived MCL-like lymphoma in mice (2021) (9)
- Aspergillus fumigatus Recognition by Dendritic Cells Negatively Regulates Allergic Lung Inflammation Through a TLR2/MyD88 Pathway. (2020) (8)
- GC Content of Early Metazoan Genes and Its Impact on Gene Expression Levels in Mammalian Cell Lines (2018) (8)
- A two-step activation mechanism of MALT1 paracaspase. (2012) (8)
- Bradyrhizobium Lipid A: Immunological Properties and Molecular Basis of Its Binding to the Myeloid Differentiation Protein-2/Toll-Like Receptor 4 Complex (2018) (8)
- Genetic relationships between A 20 / TNFAIP 3 , chronic inflammation and autoimmune disease (2011) (8)
- Tumor-educated Tregs drive organ-specific metastasis in breast cancer by impairing NK cells in the lymph node niche. (2022) (8)
- IRG1 controls immunometabolic host response and restricts intracellular Mycobacterium tuberculosis infection (2019) (8)
- Correction: A20 (Tnfaip3) Deficiency in Myeloid Cells Protects against Influenza A Virus Infection (2012) (8)
- A20 deletion in T cells modulates acute graft‐versus‐host disease in mice (2017) (8)
- GAL4 is a substrate for caspases: implications for two-hybrid screening and other GAL4-based assays. (1999) (7)
- Reprogramming of glucocorticoid receptor function by hypoxia (2021) (7)
- A novel link between Lck, Bak expression and chemosensitivity (2006) (7)
- Tumor necrosis factor: a potential antitumor agent? (1987) (7)
- The ubiquitin editing enzyme A20 (TNFAIP3) is upregulated during permanent middle cerebral artery occlusion but does not influence disease outcome (2013) (7)
- Role of the Bacterial Type VI Secretion System in the Modulation of Mammalian Host Cell Immunity. (2015) (6)
- TNF: its potential as an antitumour agent. (1988) (6)
- Single-Chain Soluble Receptor Fusion Proteins as Versatile Cytokine Inhibitors (2020) (6)
- Lithium Sensitizes Tumor Cells in an NF-κB-independent Way to Caspase Activation and Apoptosis Induced by Tumor Necrosis Factor (TNF) (2001) (6)
- Deletion of Mucosa‐Associated Lymphoid Tissue Lymphoma Translocation Protein 1 in Mouse T Cells Protects Against Development of Autoimmune Arthritis but Leads to Spontaneous Osteoporosis (2019) (5)
- Tumor Necrosis Factor Cytotoxicity is Associated with Activation of Cellular Phospholipases (1993) (5)
- Engineering a Minimal Cloning Vector from a pUC18 Plasmid Backbone with an Extended Multiple Cloning Site (2018) (5)
- Trabid epigenetically drives expression of IL-12 and IL-23 (2016) (5)
- How Good Roommates Can Protect against Microbial Sepsis. (2018) (5)
- In vitro and in vivo Action of Tumor Necrosis Factor1 (1990) (5)
- An E3 ubiquitin ligase-independent role of LUBAC. (2014) (4)
- Corrigendum: The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock (2013) (4)
- Tailored Modulation of Cellular Pro-inflammatory Responses With Disaccharide Lipid A Mimetics (2021) (4)
- MALT1-deletion in T-cells protects against the development of auto-immune arthritis, but causes spontaneous osteoporosis. (2019) (4)
- Analysis of T cells in mouse lymphoid tissue and blood with flow cytometry (2021) (4)
- Psoriasis Plays a Wild CARD. (2018) (4)
- Monitoring Ubiquitin-Coated Bacteria via Confocal Microscopy. (2016) (4)
- Spatiotemporal Changes of the Phagosomal Proteome in Dendritic Cells in Response to LPS Stimulation. (2019) (4)
- autoimmunity in aged mice differentiation and hyperactivation and cause inflammation and B cells lacking the tumor suppressor TNFAIP3/A20 display impaired (2011) (3)
- GTF3A mutations predispose to herpes simplex encephalitis by disrupting biogenesis of the host-derived RIG-I ligand RNA5SP141 (2022) (3)
- NF-κB as an emerging target in atopy (1999) (3)
- Mutations in RNU7-1 Weaken Secondary RNA Structure, Induce MCP-1 and CXCL10 in CSF, and Result in Aicardi-Goutières Syndrome with Severe End-Organ Involvement (2022) (3)
- CARD14 Signalling Ensures Cell Survival and Cancer Associated Gene Expression in Prostate Cancer Cells (2022) (3)
- Cellular expression of A20 and ABIN-3 in response to Toll-like receptor-4 stimulation. (2009) (3)
- Tumour necrosis factor: mechanism of action at the molecular, cellular and in vivo level. (1992) (3)
- Tumour Necrosis Factor and Interleukin-6: Structure and Mechanism of Action of the Molecular, Cellular and in Vivo Level (1989) (2)
- Resistance to tumor necrosis factor (TNF) cytotoxicity by autocrine TNF production is independent of intracellular signaling pathways (1997) (2)
- Lipid A structural characterization from the LPS of the Siberian psychro-tolerant Psychrobacter arcticus 273-4 grown at low temperature (2018) (2)
- NF-KB ACTIVATION BY TUMOR NECROSIS FACTOR AND INTERLEUKIN-l (2003) (2)
- Author Correction: A human immune dysregulation syndrome characterized by severe hyperinflammation with a homozygous nonsense Roquin-1 mutation (2019) (2)
- Synergy between interferon and tumor-necrosis-factor - mechanism of action (1987) (2)
- IRG1 controls host responses to restrict Mycobacterium tuberculosis infection (2022) (1)
- A Novel Type of Deubiquitinating Enzyme*□S (2003) (1)
- OP0176 The paracaspase MALT1 plays a central role in the pathogenesis of rheumatoid arthritis (2017) (1)
- Targeting the EGF receptor ectodomain in the context of cancer (2009) (1)
- PS2-048. A20/TNFAIP3 in intestinal homeostasis and inflammation (2011) (1)
- 2: Generation and characterization of IL-33 cytokine traps as anti-cytokine blockers (2014) (1)
- Editor Profile: Rudi Beyaert (2022) (1)
- A20/TNFAIP3 as a brake on intestinal inflammation and tumorigenesis (2014) (1)
- Cancer risk in immune-mediated inflammatory diseases (IMID) (2013) (1)
- Priming IKKβ kinase for action. (2014) (1)
- No ubiquitin anchors and fully RIGged. (2012) (1)
- ZBTB32 performs crosstalk with the glucocorticoid receptor and is crucial in glucocorticoid responses to starvation (2021) (1)
- Differential role of calcium in TNF-mediated apoptosis and GM-CSF secretion in a T cell hybridoma (1997) (1)
- B Inhibitor ABIN-1 κ IL-17 Signaling Triggers Degradation of the Constitutive NF - (2017) (1)
- A sensitizing function for lithium ions in tumor necrosis factor and interleukin-1 signalling (1999) (1)
- Oligodendrocyte-Specific FADD Deletion (2010) (0)
- SP0121 TNFAIP3/A20 in arthritis and autoimmunity (2013) (0)
- A20 (TNFAIP3) deficiency in myeloid cells triggers rheumatoid arthritis (2011) (0)
- Role of the adaptor protein Trif in Toll-like receptor signaling to caspase-1 (2005) (0)
- Supplementary Material for: Inflammatory Properties and Adjuvant Potential of Synthetic Glycolipids Homologous to Mycolate Esters of the Cell Wall of Mycobacterium tuberculosis (2016) (0)
- Is er leven na de (cel)dood (1998) (0)
- A CARD9 Turkisch founder mutation disrupts NF-κB signaling by inhibiting Bcl10 recruitment (2017) (0)
- “Franken-CARD9”: chimeric proteins for high-resolution studies of activating mutations in CARD10, CARD11 and CARD14 (2023) (0)
- MALT1 contributes to the pathogenicity of the virulent rabies virus CVS-11 in mice (2016) (0)
- A1.11 A20 controls activation of STAT1, but has no effect on STAT3: Implications for development of enthesitis (2016) (0)
- Tumour necrosis factor: intracellular mechanism of action (1997) (0)
- 158 Study of the Role of FAS-associated Death Domain Protein FADD in Brain Pathology by Conditional Gene Inactivation (2007) (0)
- Cytotoxicity of gamma versus alpha radiation in lymphoid cell lines with defects in the TNF receptor family mediated and NF-kappa B related apoptotic and anti-apoptotic pathways (2003) (0)
- The CARD-CC/Bcl10/paracaspase signaling complex is functionally conserved since the last common ancestor of Planulozoa (2016) (0)
- Increased Factor IX (2009) (0)
- CARD9 p.R70W, a Turkish founder mutation associated with mucosal and invasive fungal infections, disrupts downstream NF-κB signaling by inhibiting Bcl10 recruitment (2017) (0)
- MALT1 is not alone after all: identification of novel paracaspases (2015) (0)
- Amino acid sequences directed against toll-like receptors and polypeptides comprising the same for the treatment of diseases related to toll-like receptors (2009) (0)
- Engineering a highly sensitive biosensor for abscisic acid in mammalian cells (2022) (0)
- Abin to protect against hepatitis (2002) (0)
- A20 is a master switch of IL-33 signalling in macrophages and determines IL-33-induced lung immunity. (2023) (0)
- Protection against hepatitis mediated abin. (2002) (0)
- Novel carboxylate-based glycolipids: TLR4 antagonism, MD-2 binding and self-assembly properties (2019) (0)
- Normal lymphocyte homeostasis and function in MALT1 protease‐resistant HOIL‐1 knock‐in mice (2022) (0)
- Inducible Costimulator Deficiency (2009) (0)
- The yeast three-hybrid system as a tool to study caspases. (2004) (0)
- Fragility can be a good thing in cancer (2019) (0)
- A screening assay for Selective Dimerizing Glucocorticoid Receptor Agonists and Modulators (SEDIGRAM) that are effective against acute inflammation (2018) (0)
- Inhibiteurs de l'activation de nf-kb (1999) (0)
- Sensitization of T \ imor Cells to l \ imor Necrosis Factor Action by the Protein Kinase Inhibitor Staurosporine 1 (2006) (0)
- SP0075 The Multifaceted Role of Ubiquitination in Inflammation (2014) (0)
- Immune modulation by the pseudomonas type III secretion system (2007) (0)
- Cover Feature: Unusual Lipid A from a Cold‐Adapted Bacterium: Detailed Structural Characterization (ChemBioChem 18/2017) (2017) (0)
- Role of IL-33 signaling in pollutant-induced allergic airway inflammation (2018) (0)
- DemyelinationMice from Autoimmune-Mediated Paracaspase MALT1 Deficiency Protects (2013) (0)
- Two Pathways of Tumor Necrosis Factor Signal Transduction: In vitro and in vivo Implications (1993) (0)
- Editorial Board: Eur. J. Immunol. 10'15 (2015) (0)
- Correction: Dominant-negative mutations in human IL6ST underlie hyper-IgE syndrome (2020) (0)
- A sensitizing function for lithium ions in tumor necrosis factor apoptosis (1999) (0)
- IL-17 signaling inducibly degrades ABIN1, a constitutive inhibitor of inflammatory signaling (2017) (0)
- Foxp3-specific deletion of CREB generates ST-2 positive regulatory T-cells with shifts towards type 2 immune responses (2022) (0)
- Immune responses and therapeutic options in psoriasis (2021) (0)
- Two distinct ubiquitin-binding motifs in A20 mediate its anti-inflammatory and cell-protective activities (2020) (0)
- The impact of hepatocyte-specific deletion of hypoxia-inducible factors on the development of polymicrobial sepsis with focus on GR and PPARα function (2023) (0)
- Tumor necrosis factor: Mechanisms of action and potential role in cancer treatment (1993) (0)
- A clinio-pathological and biological approach to the function of the c-erbB-2 protein in breast cancer (2002) (0)
- Lipid A structural characterization from the LPS of the Siberian psychro-tolerant Psychrobacter arcticus 273-4 grown at low temperature (2018) (0)
- Taking the STING Out of Sepsis? (2020) (0)
- Gastroenterology Editorial Board (2006) (0)
- Defining the relevant combinatorial space of the PKC/CARD-CC signal transduction nodes (2017) (0)
- Fragility can be a good thing in cancer (2019) (0)
- Tumor Necrosis Factor: Mechanism of Action and its Potential for Anticancer Therapy (1992) (0)
- Engineering a Minimal 1185 Bp Cloning Vector from a Puc18 Plasmid Backbone with an Extended Multiple Cloning Site (2018) (0)
- Regulation of IL-1 receptor- and TLR-induced NF-κB activation by alternative splicing of MyD88 (2003) (0)
- Editorial Board (2011) (0)
- Pharmacological inhibition of MALT1 protease activity protects mice in a mouse model of multiple sclerosis (2014) (0)
- The generation of mitochondrial oxygen radicals as a crucial step in the cytotoxic action of TNF (1991) (0)
- 02.08 The paracaspase malt1 plays a central role in the pathogenesis of rheumatoid arthritis (2017) (0)
- IL-33TRAP-MEDIATED IL-33 neutralization does not exacerbate choroidal neovascularization, but fails to protect against retinal degeneration in a dry age-related macular degeneration model. (2021) (0)
- 161 Identification and Evaluation of Protein–Protein Interactions Involved in NF-kB Signaling Using MAPPIT Technology (2007) (0)
- Anti-Cancer Vaccine RNA-Activated Dendritic Cells As an Increases the Efficacy of Double-Stranded Attenuated Expression of A 20 Markedly (2008) (0)
- Hot off the Press A 20 : attractive without showing cleavage (2014) (0)
- Antiinflammatory Properties of a Plant-Derived Nonsteroidal, Dissociated Glucocorticoid Receptor Modulator in Experimental Autoimmune Encephalomyelitis. (2009) (0)
- DemyelinationProtects Mice from Autoimmune-Mediated Oligodendrocyte-Specific FADD Deletion (2010) (0)
- Reversion of Autoimmune Lymphoproliferative Syndrome with an anti malaria drug: Clinical and molecular observations (2000) (0)
- Proteolytic Activity of the Paracaspase MALT1 Is Involved in Epithelial Restitution and Mucosal Healing (2023) (0)
- Presenilins and Alzheimer's disease: identification of proteins that interact with presenilin I using the yeast two-hybrid system (1997) (0)
- Charaterisation of an LPS inflammation model in chickens (2006) (0)
- Selected talk 2 A phosphoproteome analysis at the host-respiratory syncytial virus interphase (2014) (0)
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What Schools Are Affiliated With Rudi Beyaert?
Rudi Beyaert is affiliated with the following schools:
