Rudolf Jaenisch

Q: What Schools Are Affiliated With Rudolf Jaenisch

Rudolf Jaenisch is affiliated with the following schools: Kyoto University, Harvard University, University of Alabama at Birmingham, Kyoto Prefectural University of Medicine, Tufts University, University of Hawaiʻi at Mānoa, Ludwig Maximilian University of Munich, Massachusetts Institute of Technology, Baylor College of Medicine, University of Hamburg

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Rudolf Jaenisch

Biology

#77

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#141

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Biotechnology

World Rank

Historical Rank

Genetics

#21

World Rank

#39

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Molecular Biology

#46

World Rank

#46

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Biology

Rudolf Jaenisch's Degrees

PhD Genetics University of Hamburg

Why Is Rudolf Jaenisch Influential?

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Rudolf Jaenisch is a founding member of the Whitehead Institute for Biomedical Research and a Professor of Biology at the Massachusetts Institute of Technology. He earned his M.D. from the University of Munich, where he specializes in transgenic science, which genetically modifies animals such as mice to study human diseases such as cancer. He completed his postdoctoral work at the Max Planck Institute, where he studied bacteriophages.

His laboratory has made breakthroughs that have improved therapies for sickle-cell anemia and Parkinson’s Disease. Jaenisch has been a vocal advocate for using transgenic methods to alter human cells, but he is opposed to human reproductive cloning.

Jaenisch’s work has received numerous awards, including the very first Genetics Prize of the Gruber Foundation, the Robert Koch Prize, the Max Delbruck Medal, Vilcek Prize in Biomedical Science, the Ernst Schering Prize, a National Medal of Science, the Wolf Prize in Medicine, the Otto Warburg Medal, and in 2015, the March of Dimes Prize in Developmental Biology. He is currently researching epigenetic regulation of gene expression, advancing our understanding of embryonic stem cells, and induced pluripotent stem cells.

He has held positions at Princeton University, Fox Chase Institute for Cancer Research, and the Salk Institute. He also contributed to the United Nation’s science conference on human cloning.

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Featured in Top Influential Biologists Today

According to Wikipedia, Rudolf Jaenisch is a Professor of Biology at MIT and a founding member of the Whitehead Institute for Biomedical Research. He is a pioneer of transgenic science, in which an animal’s genetic makeup is altered. Jaenisch has focused on creating genetically modified mice to study cancer, epigenetic reprogramming and neurological diseases.

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Rudolf Jaenisch's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals (2003) (5771)
A Bivalent Chromatin Structure Marks Key Developmental Genes in Embryonic Stem Cells (2006) (5120)
Core Transcriptional Regulatory Circuitry in Human Embryonic Stem Cells (2005) (4503)
Genome-wide maps of chromatin state in pluripotent and lineage-committed cells (2007) (4164)
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality (1992) (3993)
Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals (2009) (3820)
Histone H3K27ac separates active from poised enhancers and predicts developmental state (2010) (3345)
One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering (2013) (3180)
Polycomb complexes repress developmental regulators in murine embryonic stem cells (2006) (2592)
Genome-scale DNA methylation maps of pluripotent and differentiated cells (2008) (2515)
Control of Developmental Regulators by Polycomb in Human Embryonic Stem Cells (2006) (2393)
In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state (2007) (2319)
Role for DNA methylation in genomic imprinting (1993) (2197)
Epigenetic memory in induced pluripotent stem cells (2010) (2191)
A Chromatin Landmark and Transcription Initiation at Most Promoters in Human Cells (2007) (1979)
WT-1 is required for early kidney development (1993) (1963)
Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution. (2007) (1751)
MyoD or Myf-5 is required for the formation of skeletal muscle (1993) (1676)
HIF-1α Is Essential for Myeloid Cell-Mediated Inflammation (2003) (1651)
Treatment of Sickle Cell Anemia Mouse Model with iPS Cells Generated from Autologous Skin (2007) (1590)
Targeted Deletion Reveals Essential and Overlapping Functions of the miR-17∼92 Family of miRNA Clusters (2008) (1578)
Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors (2009) (1558)
Simplified mammalian DNA isolation procedure. (1991) (1556)
One-Step Generation of Mice Carrying Reporter and Conditional Alleles by CRISPR/Cas-Mediated Genome Engineering (2013) (1475)
HDAC2 negatively regulates memory formation and synaptic plasticity (2009) (1429)
Connecting microRNA Genes to the Core Transcriptional Regulatory Circuitry of Embryonic Stem Cells (2008) (1428)
Stem Cells, the Molecular Circuitry of Pluripotency and Nuclear Reprogramming (2008) (1417)
Chromosomal Instability and Tumors Promoted by DNA Hypomethylation (2003) (1382)
Derepression of BDNF Transcription Involves Calcium-Dependent Phosphorylation of MeCP2 (2003) (1257)
Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice (2001) (1248)
Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease (2008) (1228)
Induction of Tumors in Mice by Genomic Hypomethylation (2003) (1193)
YAP1 Increases Organ Size and Expands Undifferentiated Progenitor Cells (2007) (1165)
A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival. (2001) (1148)
Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages (1992) (1113)
Mice lacking brain-derived neurotrophic factor develop with sensory deficits (1994) (1073)
Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor (1995) (1062)
Dissecting direct reprogramming through integrative genomic analysis (2008) (1058)
Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases (2009) (1054)
β2-Microglobulin deficient mice lack CD4−8+ cytolytic T cells (1990) (1044)
DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal (2007) (1034)
Direct cell reprogramming is a stochastic process amenable to acceleration (2009) (1020)
Reduced representation bisulfite sequencing for comparative high-resolution DNA methylation analysis (2005) (1014)
Inactivation of MyoD in mice leads to up-regulation of the myogenic HLH gene Myf-5 and results in apparently normal muscle development (1992) (1001)
Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a. (2000) (965)
DNA hypomethylation leads to elevated mutation rates (1998) (959)
HIF-1alpha is essential for myeloid cell-mediated inflammation. (2003) (958)
Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system (1992) (952)
Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells (2014) (869)
Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells. (2008) (860)
Editing DNA Methylation in the Mammalian Genome (2016) (853)
Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs (2010) (839)
Ectopic Expression of Oct-4 Blocks Progenitor-Cell Differentiation and Causes Dysplasia in Epithelial Tissues (2005) (837)
De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells. (1996) (822)
Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents (1994) (817)
Single-Cell Expression Analyses during Cellular Reprogramming Reveal an Early Stochastic and a Late Hierarchic Phase (2012) (815)
Direct reprogramming of genetically unmodified fibroblasts into pluripotent stem cells (2007) (794)
Suppression of intestinal neoplasia by DNA hypomethylation (1995) (781)
Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity. (2001) (776)
Activation of proto-oncogenes by disruption of chromosome neighborhoods (2015) (769)
Alpha 3 beta 1 integrin has a crucial role in kidney and lung organogenesis. (1996) (739)
Epigenetic Instability in ES Cells and Cloned Mice (2001) (732)
Targeted inactivation of the muscle regulatory gene Myf-5 results in abnormal rib development and perinatal death (1992) (719)
Pluripotency and Cellular Reprogramming: Facts, Hypotheses, Unresolved Issues (2010) (718)
Chromosomal silencing and localization are mediated by different domains of Xist RNA (2002) (715)
Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation (2001) (713)
Xist-deficient mice are defective in dosage compensation but not spermatogenesis. (1997) (705)
Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system (2013) (701)
Toxicity of 5-aza-2'-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation. (1994) (681)
Generation of Isogenic Pluripotent Stem Cells Differing Exclusively at Two Early Onset Parkinson Point Mutations (2011) (675)
Cre-lox-regulated conditional RNA interference from transgenes. (2004) (660)
c-Myc is dispensable for direct reprogramming of mouse fibroblasts. (2008) (643)
Hybrid vigor, fetal overgrowth, and viability of mice derived by nuclear cloning and tetraploid embryo complementation (2001) (638)
Systematic Identification of Culture Conditions for Induction and Maintenance of Naive Human Pluripotency (2014) (629)
Correction of a Genetic Defect by Nuclear Transplantation and Combined Cell and Gene Therapy (2002) (614)
Transcription factor AP-2 essential for cranial closure and craniofacial development (1996) (612)
Reduced cortical activity due to a shift in the balance between excitation and inhibition in a mouse model of Rett syndrome. (2005) (610)
Functional analysis of activins during mammalian development (1995) (607)
Nuclear Cloning and Epigenetic Reprogramming of the Genome (2001) (601)
YY1 Is a Structural Regulator of Enhancer-Promoter Loops (2017) (588)
Direct Reprogramming of Terminally Differentiated Mature B Lymphocytes to Pluripotency (2008) (576)
A shift from reversible to irreversible X inactivation is triggered during ES cell differentiation. (2000) (571)
The Disease Progression of Mecp2 Mutant Mice Is Affected by the Level of BDNF Expression (2006) (562)
Monoclonal mice generated by nuclear transfer from mature B and T donor cells (2002) (546)
Microfluidic Control of Cell Pairing and Fusion (2009) (546)
Type III collagen is crucial for collagen I fibrillogenesis and for normal cardiovascular development. (1997) (540)
Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice (2009) (535)
Dissecting direct reprogramming through integrative genomic analysis (2008) (534)
Reprogramming of murine and human somatic cells using a single polycistronic vector (2009) (520)
Combinatorial Development of Biomaterials for Clonal Growth of Human Pluripotent Stem Cells (2010) (503)
De novo methylation and expression of retroviral genomes during mouse embryogenesis (1982) (498)
Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells (2009) (495)
Genetic engineering of human ES and iPS cells using TALE nucleases (2011) (489)
MHC class I deficiency: susceptibility to natural killer (NK) cells and impaired NK activity. (1991) (487)
Germ line integration and Mendelian transmission of the exogenous Moloney leukemia virus. (1976) (479)
Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats (2010) (479)
Efficient method to generate single‐copy transgenic mice by site‐specific integration in embryonic stem cells (2006) (475)
Synergism of Xist Rna, DNA Methylation, and Histone Hypoacetylation in Maintaining X Chromosome Inactivation (2001) (474)
Tet1 is dispensable for maintaining pluripotency and its loss is compatible with embryonic and postnatal development. (2011) (472)
A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types (2008) (468)
DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction (2009) (465)
ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damage (1998) (462)
Nuclear reprogramming and pluripotency (2006) (456)
Complementary roles of BDNF and NT-3 in vestibular and auditory development (1995) (455)
Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei (2003) (455)
Promoter CpG methylation contributes to ES cell gene regulation in parallel with Oct4/Nanog, PcG complex, and histone H3 K4/K27 trimethylation. (2008) (451)
Efficient derivation of microglia-like cells from human pluripotent stem cells (2016) (448)
Maternal and zygotic Dnmt1 are necessary and sufficient for the maintenance of DNA methylation imprints during preimplantation development. (2008) (448)
Generating genetically modified mice using CRISPR/Cas-mediated genome engineering (2014) (446)
The MyoD family of transcription factors and skeletal myogenesis (1995) (443)
THE ROLE OF DNA METHYLATION IN CANCER GENETICS AND EPIGENETICS (1996) (441)
Chromatin structure and gene expression programs of human embryonic and induced pluripotent stem cells. (2010) (436)
Wnt signaling promotes reprogramming of somatic cells to pluripotency. (2008) (435)
Rejection of class I MHC-deficient haemopoietic cells by irradiated MHC-matched mice (1991) (430)
DNA Methylation in the Human Cerebral Cortex Is Dynamically Regulated throughout the Life Span and Involves Differentiated Neurons (2007) (427)
α3β1 Integrin Is Required for Normal Development of the Epidermal Basement Membrane (1997) (422)
Abnormal gene expression in cloned mice derived from embryonic stem cell and cumulus cell nuclei (2002) (419)
Activin/inhibin beta B subunit gene disruption leads to defects in eyelid development and female reproduction. (1994) (417)
Simian virus 40 DNA sequences in DNA of healthy adult mice derived from preimplantation blastocysts injected with viral DNA. (1974) (416)
Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor. (2001) (413)
Clearance of influenza virus respiratory infection in mice lacking class I major histocompatibility complex-restricted CD8+ T cells (1991) (411)
Identification and Rescue of α-Synuclein Toxicity in Parkinson Patient–Derived Neurons (2013) (410)
Oct4 expression is not required for mouse somatic stem cell self-renewal. (2007) (407)
Technical challenges in using human induced pluripotent stem cells to model disease. (2009) (401)
Mechanisms and models of somatic cell reprogramming (2013) (401)
Combined deficiency of Tet1 and Tet2 causes epigenetic abnormalities but is compatible with postnatal development. (2013) (400)
DNA methylation and imprinting: why bother? (1997) (400)
Tet1 Is Critical for Neuronal Activity-Regulated Gene Expression and Memory Extinction (2013) (397)
Parkinson-associated risk variant in distal enhancer of α-synuclein modulates target gene expression (2016) (395)
Derivation of Pre-X Inactivation Human Embryonic Stem Cells under Physiological Oxygen Concentrations (2010) (394)
DNA hypomethylation can activate Xist expression and silence X-linked genes. (1996) (390)
Reprogramming of human peripheral blood cells to induced pluripotent stem cells. (2010) (390)
A drug-inducible system for direct reprogramming of human somatic cells to pluripotency. (2008) (383)
Induced Pluripotent Stem Cells Meet Genome Editing. (2016) (383)
Sensory but not motor neuron deficits in mice lacking NT4 and BDNF (1995) (380)
Mice cloned from olfactory sensory neurons (2004) (377)
Molecular Criteria for Defining the Naive Human Pluripotent State (2016) (377)
Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages. (1992) (376)
A generic intron increases gene expression in transgenic mice (1991) (367)
p75-Deficient trigeminal sensory neurons have an altered response to NGF but not to other neurotrophins (1993) (366)
DNA Hypomethylation Perturbs the Function and Survival of CNS Neurons in Postnatal Animals (2001) (364)
Expression of MeCP2 in postmitotic neurons rescues Rett syndrome in mice. (2004) (363)
Transcriptional profiling of a mouse model for Rett syndrome reveals subtle transcriptional changes in the brain (2002) (360)
Loss of Cardiac microRNA-Mediated Regulation Leads to Dilated Cardiomyopathy and Heart Failure (2009) (359)
Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4 (2009) (358)
Conditional deletion of Xist disrupts histone macroH2A localization but not maintenance of X inactivation (1999) (355)
Reprogramming of a melanoma genome by nuclear transplantation. (2004) (350)
Germ-line transmission of a disrupted β2microglobulin gene produced by homologous recombination in embryonic stem cells (1989) (349)
3D Chromosome Regulatory Landscape of Human Pluripotent Cells. (2016) (347)
Reprogramming of Neural Progenitor Cells into Induced Pluripotent Stem Cells in the Absence of Exogenous Sox2 Expression (2008) (344)
Activation and transposition of endogenous retroviral elements in hypomethylation induced tumors in mice (2008) (340)
H2AZ Is Enriched at Polycomb Complex Target Genes in ES Cells and Is Necessary for Lineage Commitment (2008) (337)
Generation of mice from wild-type and targeted ES cells by nuclear cloning (2000) (334)
Isogenic Human iPSC Parkinson’s Model Shows Nitrosative Stress-Induced Dysfunction in MEF2-PGC1α Transcription (2013) (332)
Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia (2010) (331)
Direct Reprogramming of Terminally Differentiated Mature B Lymphocytes to Pluripotency (2008) (330)
A 450 kb Transgene Displays Properties of the Mammalian X-Inactivation Center (1996) (329)
Hallmarks of pluripotency (2015) (322)
Rapid generation of inducible mouse mutants. (2003) (316)
Reprogramming factor stoichiometry influences the epigenetic state and biological properties of induced pluripotent stem cells. (2011) (315)
Embryonic lethal mutation in mice induced by retrovirus insertion into the α1(I) collagen gene (1983) (315)
Contrasting roles for histone 3 lysine 27 demethylases in acute lymphoblastic leukemia (2014) (311)
Loss of methylation activates Xist in somatic but not in embryonic cells. (1995) (311)
Setting Standards for Human Embryonic Stem Cells (2003) (311)
Chromosomal position and activation of retroviral genomes inserted into the germ line of mice (1981) (307)
X Chromosome Inactivation Is Mediated by Xist RNA Stabilization (1997) (306)
Development: DNA methylation in Drosophila melanogaster (2000) (298)
Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome. (2010) (295)
β2-Microglobulin–Deficient NOD Mice Do Not Develop Insulitis or Diabetes (1994) (295)
Retroviral Expression in Embryonic Stem Cells and Hematopoietic Stem Cells (2000) (292)
Germ-line passage is required for establishment of methylation and expression patterns of imprinted but not of nonimprinted genes. (1996) (291)
Optimal-Transport Analysis of Single-Cell Gene Expression Identifies Developmental Trajectories in Reprogramming (2019) (290)
Dnmt3b promotes tumorigenesis in vivo by gene-specific de novo methylation and transcriptional silencing. (2007) (290)
Long-range cis effects of ectopic X-inactivation centres on a mouse autosome (1997) (289)
Rescue of Fragile X Syndrome Neurons by DNA Methylation Editing of the FMR1 Gene (2018) (288)
Induction of Expansion and Folding in Human Cerebral Organoids. (2017) (287)
Deletion of integrin alpha 1 by homologous recombination permits normal murine development but gives rise to a specific deficit in cell adhesion. (1996) (285)
Mice lacking alpha 1 (IX) collagen develop noninflammatory degenerative joint disease. (1994) (284)
Reprogramming Efficiency Following Somatic Cell Nuclear Transfer Is Influenced by the Differentiation and Methylation State of the Donor Nucleus (2006) (282)
The recombination activating gene-1 (RAG-1) transcript is present in the murine central nervous system (1991) (280)
Global transcriptional and translational repression in human-embryonic-stem-cell-derived Rett syndrome neurons. (2013) (280)
Embryonic lethal mutation in mouse collagen I gene causes rupture of blood vessels and is associated with erythropoietic and mesenchymal cell death (1984) (279)
p75-deficient embryonic dorsal root sensory and neonatal sympathetic neurons display a decreased sensitivity to NGF. (1994) (279)
Suppressed Epileptogenesis in BDNF Mutant Mice (1995) (278)
Partial rescue of MeCP2 deficiency by postnatal activation of MeCP2 (2007) (278)
Mice lacking major histocompatibility complex class I and class II molecules. (1993) (275)
A targeted mutation at the known collagenase cleavage site in mouse type I collagen impairs tissue remodeling (1995) (274)
Metastable pluripotent states in NOD-mouse-derived ESCs. (2009) (273)
Loss of Tet enzymes compromises proper differentiation of embryonic stem cells. (2014) (272)
Dnmt1 Overexpression Causes Genomic Hypermethylation, Loss of Imprinting, and Embryonic Lethality (2002) (270)
DNA Methyltransferase Contributes to Delayed Ischemic Brain Injury (2000) (270)
Opposing effects of DNA hypomethylation on intestinal and liver carcinogenesis. (2005) (267)
X-Chromosome inactivation in cloned mouse embryos. (2000) (266)
DNA methylation and cancer. (1994) (265)
Delayed clearance of Sendai virus in mice lacking class I MHC-restricted CD8+ T cells. (1992) (265)
Global loss of imprinting leads to widespread tumorigenesis in adult mice. (2005) (265)
Functional integration of dopaminergic neurons directly converted from mouse fibroblasts. (2011) (259)
Molecular control of pluripotency. (2006) (254)
De novo methylation, expression, and infectivity of retroviral genomes introduced into embryonal carcinoma cells. (1982) (248)
Generation of nuclear transfer-derived pluripotent ES cells from cloned Cdx2-deficient blastocysts (2006) (247)
Postnatal Loss of Methyl-CpG Binding Protein 2 in the Forebrain is Sufficient to Mediate Behavioral Aspects of Rett Syndrome in Mice (2006) (237)
Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation (2015) (233)
Toward eliminating HLA class I expression to generate universal cells from allogeneic donors. (2013) (232)
Retrovirus integration and chromatin structure: Moloney murine leukemia proviral integration sites map near DNase I-hypersensitive sites (1987) (231)
Nuclear transplantation, embryonic stem cells, and the potential for cell therapy. (2003) (230)
Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function (2009) (229)
Generation of iPSCs from cultured human malignant cells. (2010) (224)
RNA and the Epigenetic Regulation of X Chromosome Inactivation (1998) (223)
Impaired autophagy in the lipid-storage disorder Niemann-Pick type C1 disease. (2013) (220)
ES cells derived from cloned and fertilized blastocysts are transcriptionally and functionally indistinguishable. (2006) (219)
Germline integration of Moloney murine leukemia virus at the Mov13 locus leads to recessive lethal mutation and early embryonic death (1983) (218)
Differential role of the low affinity neurotrophin receptor (p75) in retrograde axonal transport of the neurotrophins (1995) (211)
Targeted mutation in the col5a2 gene reveals a regulatory role for type V collagen during matrix assembly (1995) (211)
Mammalian (cytosine-5) methyltransferases cause genomic DNA methylation and lethality in Drosophila (1999) (210)
Retroviruses as probes for mammalian development: Allocation of cells to the somatic and germ cell lineages (1986) (207)
Mutagenicity of 5-aza-2'-deoxycytidine is mediated by the mammalian DNA methyltransferase. (1997) (204)
Dependence on p75 for innervation of some sympathetic targets. (1994) (202)
Perinatal lethal osteogenesis imperfecta in transgenic mice bearing an engineered mutant pro-α1(I) collagen gene (1988) (201)
Trisomy eight in ES cells is a common potential problem in gene targeting and interferes with germ line transmission (1997) (201)
Optimal-Transport Analysis of Single-Cell Gene Expression Identifies Developmental Trajectories in Reprogramming (2019) (200)
Antisense Transcription through theXist Locus Mediates Tsix Function in Embryonic Stem Cells (2001) (199)
Chromosomal position or virus mutation permits retrovirus expression in embryonal carcinoma cells (1986) (198)
Single-gene transgenic mouse strains for reprogramming adult somatic cells (2010) (197)
Retrovirus-induced de novo methylation of flanking host sequences correlates with gene inactivity (1985) (192)
DNA methylation and gene expression: endogenous retroviral genome becomes infectious after molecular cloning. (1981) (191)
TET1 is a tumor suppressor of hematopoietic malignancy (2015) (191)
The role of DNA methylation in cancer genetic and epigenetics. (1996) (189)
Normal development and growth of mice carrying a targeted disruption of the alpha 1 retinoic acid receptor gene. (1993) (187)
NT-3 facilitates hippocampal plasticity and learning and memory by regulating neurogenesis. (2006) (184)
Infection of preimplantation mouse embryos and of newborn mice with leukemia virus: tissue distribution of viral DNA and RNA and leukemogenesis in the adult animal. (1975) (179)
Genetic and Chemical Correction of Cholesterol Accumulation and Impaired Autophagy in Hepatic and Neural Cells Derived from Niemann-Pick Type C Patient-Specific iPS Cells (2014) (178)
Microinjection of cloned retroviral genomes into mouse zygotes: integration and expression in the animal (1981) (177)
Mutations in the WRN Gene in Mice Accelerate Mortality in a p53-Null Background (2000) (176)
Association of the Bloom syndrome protein with topoisomerase IIIalpha in somatic and meiotic cells. (2000) (175)
TET1 plays an essential oncogenic role in MLL-rearranged leukemia (2013) (175)
Human Naive Pluripotent Stem Cells Model X Chromosome Dampening and X Inactivation. (2017) (173)
MeCP2-regulated miRNAs control early human neurogenesis through differential effects on ERK and AKT signaling (2017) (172)
Nuclear cloning of embryonal carcinoma cells. (2004) (172)
SOX2 Co-Occupies Distal Enhancer Elements with Distinct POU Factors in ESCs and NPCs to Specify Cell State (2013) (172)
Zfx mutation results in small animal size and reduced germ cell number in male and female mice. (1997) (172)
Ablation of de novo DNA methyltransferase Dnmt3a in the nervous system leads to neuromuscular defects and shortened lifespan (2007) (172)
Regulation of ES cell differentiation by functional and conformational modulation of p53 (1997) (170)
Transgenic mouse model of kidney disease: Insertional inactivation of ubiquitously expressed gene leads to nephrotic syndrome (1990) (167)
Insertion of retrovirus into the first intron of alpha 1(I) collagen gene to embryonic lethal mutation in mice. (1984) (165)
Characterization of a highly variable eutherian microRNA gene. (2005) (163)
Hominoid-Specific Transposable Elements and KZFPs Facilitate Human Embryonic Genome Activation and Control Transcription in Naive Human ESCs (2019) (162)
Role of the Xist Gene in X Chromosome Choosing (1998) (161)
Recombination signatures distinguish embryonic stem cells derived by parthenogenesis and somatic cell nuclear transfer. (2007) (161)
Functional redundancy of the muscle-specific transcription factors Myf5 and myogenin (1996) (159)
Nuclear transplantation, embryonic stem cells and the potential for cell therapy. (2003) (158)
X-linked H3K27me3 demethylase Utx is required for embryonic development in a sex-specific manner (2012) (157)
Chromosomal deletion complexes in mice by radiation of embryonic stem cells (1997) (155)
Direct reprogramming of fibroblasts into embryonic Sertoli-like cells by defined factors. (2012) (153)
Studies on the physiological role of brain-derived neurotrophic factor and neurotrophin-3 in knockout mice. (1995) (152)
Skin graft rejection by beta 2-microglobulin-deficient mice (1992) (150)
Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment. (2018) (150)
Dynamics of lineage commitment revealed by single-cell transcriptomics of differentiating embryonic stem cells (2016) (149)
Developmentally regulated alterations in Polycomb repressive complex 1 proteins on the inactive X chromosome (2004) (149)
Surface-engineered substrates for improved human pluripotent stem cell culture under fully defined conditions (2011) (148)
Treatment of mice with 5-azacytidine efficiently activates silent retroviral genomes in different tissues. (1985) (148)
Mir-290–295 deficiency in mice results in partially penetrant embryonic lethality and germ cell defects (2011) (146)
MyoD expression marks the onset of skeletal myogenesis in Myf-5 mutant mice. (1994) (145)
The developmental potential of iPSCs is greatly influenced by reprogramming factor selection. (2014) (139)
Male and female mice derived from the same embryonic stem cell clone by tetraploid embryo complementation (2002) (138)
Retroviruses and embryogenesis: Microinjection of Moloney leukemia virus into midgestation mouse embryos (1980) (138)
Fibronectin binding site in type I collagen regulates fibronectin fibril formation (1993) (138)
Non-imprinted Igf2r expression decreases growth and rescues the Tme mutation in mice. (2001) (137)
Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity (2015) (137)
Infectivity and methylation of retroviral genomes is correlated with expression in the animal (1981) (136)
Neurotrophin–3 is required for proper cerebellar development (1999) (136)
Mitogenicity of DNA from different organisms for murine B cells. (1997) (136)
Most gamma delta T cells develop normally in beta 2-microglobulin-deficient mice. (1992) (133)
Targeted mutagenesis of Timp-1 reveals that lung tumor invasion is influenced by Timp-1 genotype of the tumor but not by that of the host. (1996) (132)
A Systematic Approach to Identify Candidate Transcription Factors that Control Cell Identity (2015) (132)
Parkinson-associated risk variant in enhancer element produces subtle effect on target gene expression (2016) (132)
Functional characterization of cardiomyocytes derived from murine induced pluripotent stem cells in vitro (2009) (132)
DNMT3B Expression Might Contribute to CpG Island Methylator Phenotype in Colorectal Cancer (2009) (131)
Reverse-transcribed SARS-CoV-2 RNA can integrate into the genome of cultured human cells and can be expressed in patient-derived tissues (2021) (130)
Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis. (2007) (129)
Abrogation of resistance to Theiler's virus-induced demyelination in H-2b mice deficient in beta 2-microglobulin. (1993) (128)
Deletion of the de novo DNA methyltransferase Dnmt3a promotes lung tumor progression (2011) (127)
Stem cells and interspecies chimaeras (2016) (126)
Broader implications of defining standards for the pluripotency of iPSCs. (2009) (126)
Retroviruses and insertional mutagenesis in mice: proviral integration at the Mov 34 locus leads to early embryonic death. (1987) (124)
Brain-Derived Neurotrophic Factor Is Essential for Opiate-Induced Plasticity of Noradrenergic Neurons (2002) (124)
Prenatal and postnatal requirements of NT-3 for sympathetic neuroblast survival and innervation of specific targets. (1996) (124)
Nuclear transplantation: lessons from frogs and mice. (2002) (123)
Molecular control of induced pluripotency. (2014) (123)
Jointly reduced inhibition and excitation underlies circuit-wide changes in cortical processing in Rett syndrome (2016) (123)
Isogenic Human iPSC Parkinson’s Model Shows Nitrosative Stress-Induced Dysfunction in MEF2-PGC1α Transcription (2013) (123)
Meiotic sex chromosome inactivation in male mice with targeted disruptions of Xist (2002) (123)
Asynchronous replication timing of imprinted loci is independent of DNA methylation, but consistent with differential subnuclear localization. (2003) (122)
Mammalian nuclear transfer (2006) (122)
Two-Step Imprinted X Inactivation: Repeat versus Genic Silencing in the Mouse (2010) (121)
DNA methylation, genomic imprinting, and mammalian development. (1993) (120)
Dnmt1 Expression in Pre- and Postimplantation Embryogenesis and the Maintenance of IAP Silencing (2004) (120)
Expression Pattern of the Rett Syndrome Gene MeCP2 in Primate Prefrontal Cortex (2001) (120)
Chromatin proteomic profiling reveals novel proteins associated with histone-marked genomic regions (2015) (120)
Replicating SV40 molecules containing closed circular template DNA strands. (1971) (120)
Single-cell analysis reveals that expression of nanog is biallelic and equally variable as that of other pluripotency factors in mouse ESCs. (2013) (119)
Human cloning - the science and ethics of nuclear transplantation. (2004) (119)
TALEN-mediated editing of the Mouse Y Chromosome (2013) (117)
Don't Clone Humans! (2001) (117)
Different Collagenase Gene Products Have Different Roles in Degradation of Type I Collagen* (1996) (116)
De novo DNA methylation by Dnmt3a and Dnmt3b is dispensable for nuclear reprogramming of somatic cells to a pluripotent state. (2011) (116)
The pluripotency regulator Oct4: A role in somatic stem cells? (2008) (115)
Tracing Dynamic Changes of DNA Methylation at Single-Cell Resolution (2015) (114)
Hematopoietic Precursor Cells Transiently Reestablish Permissiveness for XInactivation (2006) (114)
Serrate2 is disrupted in the mouse limb-development mutant syndactylism (1997) (113)
Structure of a full-length cDNA clone for the prepro alpha 1(I) chain of human type I procollagen. (1988) (112)
Suppression of Intestinal Neoplasia by Deletion of Dnmt3b (2006) (111)
Germ line transmission of a yeast artificial chromosome spanning the murine alpha 1(I) collagen locus. (1993) (110)
Double replacement: strategy for efficient introduction of subtle mutations into the murine Col1a-1 gene by homologous recombination in embryonic stem cells. (1994) (110)
Generation of collagenase-resistant collagen by site-directed mutagenesis of murine pro alpha 1(I) collagen gene. (1990) (109)
Increased postischemic brain injury in mice deficient in uracil-DNA glycosylase. (2004) (109)
Effects of cerebral ischemia in mice lacking DNA methyltransferase 1 in post-mitotic neurons (2001) (108)
Retrovirus insertion inactivates mouse α 1(I) collagen gene by blocking initiation of transcription (1986) (108)
Genetic and molecular identification of three human TPP1 functions in telomerase action: recruitment, activation, and homeostasis set point regulation (2014) (107)
Integration of Moloney leukaemia virus into the germ line of mice: correlation between site of integration and virus activation (1980) (107)
DGCR 8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal (2007) (107)
Baculovirus-mediated expression and characterization of the full-length murine DNA methyltransferase. (1997) (107)
Initial differentiation of the metanephric mesenchyme is independent of WT1 and the ureteric bud. (1999) (106)
Nanoparticles for gene transfer to human embryonic stem cell colonies. (2008) (106)
Retrovirus-induced lethal mutation in collagen I gene of mice is associated with an altered chromatin structure (1984) (106)
Knocking the NT4 gene into the BDNF locus rescues BDNF deficient mice and reveals distinct NT4 and BDNF activities (2000) (105)
Tissue-specific and ectopic expression of genes introduced into transgenic mice by retroviruses. (1986) (102)
Systematic Identification of Culture Conditions for Induction and Maintenance of Naive Human Pluripotency (2014) (102)
Different Roles for Tet1 and Tet2 Proteins in Reprogramming-Mediated Erasure of Imprints Induced by EGC Fusion (2013) (102)
A Latent Pro-Survival Function for the Mir-290-295 Cluster in Mouse Embryonic Stem Cells (2011) (101)
A murine skeletal adaptation that significantly increases cortical bone mechanical properties. Implications for human skeletal fragility. (1993) (101)
Retrovirus-induced insertional mutation in Mov13 mice affects collagen I expression in a tissue-specific manner (1989) (101)
Metastable Pluripotent States in NOD-Mouse-Derived ESCs (2015) (101)
Myogenin can substitute for Myf5 in promoting myogenesis but less efficiently. (1997) (100)
Transgenic Mice with Defined Combinations of Drug Inducible Reprogramming Factors (2008) (99)
A transgenic mouse strain expressing four drug-selectable marker genes. (1997) (98)
Messenger RNAs encoding mouse histone macroH2A1 isoforms are expressed at similar levels in male and female cells and result from alternative splicing. (1999) (97)
Dependence of developing group Ia afferents on neurotrophin‐3 (1995) (97)
Insertion of the bacterial gpt gene into the germ line of mice by retroviral infection. (1985) (96)
Insertional mutagenesis in mice (1987) (96)
Pluripotent stem cells are highly susceptible targets for syngeneic, allogeneic, and xenogeneic natural killer cells (2010) (95)
Uracil DNA Glycosylase Activity Is Dispensable for Immunoglobulin Class Switch (2004) (95)
In situ genome sequencing resolves DNA sequence and structure in intact biological samples (2020) (95)
Dynamic Relocalization of Histone Macroh2a1 from Centrosomes to Inactive X Chromosomes during X Inactivation (2000) (94)
Cardiac Myocytes Derived from Murine Reprogrammed Fibroblasts: Intact Hormonal Regulation, Cardiac Ion Channel Expression and Development of Contractility (2009) (93)
Complementation of methylation deficiency in embryonic stem cells by a DNA methyltransferase minigene. (1996) (92)
Parental origin-specific expression of Mash2 is established at the time of implantation with its imprinting mechanism highly resistant to genome-wide demethylation (1999) (92)
Stem Cells, Genome Editing, and the Path to Translational Medicine (2018) (92)
New advances in iPS cell research do not obviate the need for human embryonic stem cells. (2007) (92)
High rate of recombination and double crossovers in the mouse pseudoautosomal region during male meiosis. (1987) (91)
Folate deficiency induces genomic uracil misincorporation and hypomethylation but does not increase DNA point mutations. (2009) (91)
Normal epithelial branching morphogenesis in the absence of collagen I. (1986) (91)
Human iPSC-derived microglia assume a primary microglia-like state after transplantation into the neonatal mouse brain (2019) (91)
Human induced pluripotent stem cell-derived glial cells and neural progenitors display divergent responses to Zika and dengue infections (2018) (90)
A novel member of the F-box/WD40 gene family, encoding dactylin, is disrupted in the mouse dactylaplasia mutant (1999) (90)
Retrovirus genomes methylated by mammalian but not bacterial methylase are non-infectious (1983) (89)
Folate Deficiency Induces Neurodegeneration and Brain Dysfunction in Mice Lacking Uracil DNA Glycosylase (2008) (89)
S-Nitrosylation of PINK1 Attenuates PINK1/Parkin-Dependent Mitophagy in hiPSC-Based Parkinson's Disease Models. (2017) (89)
Transgenic animals. (1988) (88)
Blockade of transgenic gamma delta T cell development in beta 2‐microglobulin deficient mice. (1992) (88)
X‐chromosome inactivation during spermatogenesis is regulated by an Xist/Tsix‐independent mechanism in the mouse (2002) (86)
Embryonic lethal mutation in mice induced by retrovirus insertion into the alpha 1(I) collagen gene. (1983) (85)
Methylation, expression and chromosomal position of genes in mammals. (1984) (85)
Replication-competent Moloney murine leukemia virus carrying a bacterial suppressor tRNA gene: selective cloning of proviral and flanking host sequences. (1985) (84)
Human Intestinal Tissue with Adult Stem Cell Properties Derived from Pluripotent Stem Cells (2014) (84)
DNA Methylation in Early Mammalian Development (1984) (83)
Ischemic Brain Damage in Mice after Selectively Modifying BDNF or NT4 Gene Expression (2000) (82)
MeCP2 links heterochromatin condensates and neurodevelopmental disease (2020) (80)
The (epi)genetic control of mammalian X-chromosome inactivation. (1997) (80)
Induced Pluripotency and Epigenetic Reprogramming. (2015) (80)
Defining Hematopoietic Stem and Progenitor Cell Turnover by Analysis of Histone 2B-GFP Dilution (2008) (79)
Musashi proteins are post-transcriptional regulators of the epithelial-luminal cell state (2014) (79)
Mammalian neural crest cells participate in normal embryonic development on microinjection into post-implantation mouse embryos (1985) (79)
Genome-wide CRISPR screen for Zika virus resistance in human neural cells (2019) (78)
Analysis of the mouse embryonic stem cell regulatory networks obtained by ChIP-chip and ChIP-PET (2008) (77)
Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders (2015) (76)
Pharmacological enhancement of KCC2 gene expression exerts therapeutic effects on human Rett syndrome neurons and Mecp2 mutant mice (2019) (75)
Ubiquitous expression and embryonic requirement for RNA polymerase II coactivator subunit Srb7 in mice. (1999) (74)
Control of γδ T‐Cell Development (1991) (73)
At most three ES cells contribute to the somatic lineages of chimeric mice and of mice produced by ES-tetraploid complementation. (2004) (73)
Effects of mutations at the W locus (c-kit) on inner ear pigmentation and function in the mouse. (1994) (73)
Reprogramming of Postnatal Neurons into Induced Pluripotent Stem Cells by Defined Factors (2011) (73)
Retroviruses and mouse embryos: a rapid model for neurovirulence and transplacental antiviral therapy. (1987) (72)
Combined Loss of Tet1 and Tet2 Promotes B Cell, but Not Myeloid Malignancies, in Mice. (2015) (71)
Generation of Isogenic Pluripotent Stem Cells Differing Exclusively at Two Early Onset Parkinson Point Mutations (2011) (70)
Higher Vulnerability and Stress Sensitivity of Neuronal Precursor Cells Carrying an Alpha-Synuclein Gene Triplication (2014) (70)
Reconstruction of developmental landscapes by optimal-transport analysis of single-cell gene expression sheds light on cellular reprogramming (2017) (67)
Introduction of a selectable gene into different animal tissue by a retrovirus recombinant vector. (1984) (67)
Severe deficits in 5-HT2A -mediated neurotransmission in BDNF conditional mutant mice. (2006) (67)
Provirus integration into a gene encoding a ubiquitin-conjugating enzyme results in a placental defect and embryonic lethality. (1996) (66)
Clonal Cell Lines Produced by Infection of Neocortical Neuroblasts Using Multiple Oncogenes Transduced by Retroviruses (1996) (66)
Phenotypic rescue of mutant brown melanocytes by a retrovirus carrying a wild-type tyrosinase-related protein gene. (1990) (65)
Early TCR Expression and Aberrant T Cell Development in Mice with Endogenous Prerearranged T Cell Receptor Genes1 (2007) (65)
Two distinct sequence elements mediate retroviral gene expression in embryonal carcinoma cells (1987) (65)
Moloney leukemia virus gene expression and gene amplification in preleukemic and leukemic BALB/Mo mice. (1979) (64)
Somatic cell nuclear transfer and derivation of embryonic stem cells in the mouse. (2008) (64)
Genes methylated by DNA methyltransferase 3b are similar in mouse intestine and human colon cancer. (2011) (63)
A Short DNA Methyltransferase Isoform Restores Methylation In Vivo * (1998) (63)
Dose-dependent roles for canonical Wnt signalling in de novo crypt formation and cell cycle properties of the colonic epithelium (2013) (63)
Type I collagen‐deficient Mov‐13 mice do not retain SPARC in the extracellular matrix: Implications for fibroblast function (1996) (61)
Role of abortive retroviral infection of neurons in spongiform CNS degeneration (1990) (61)
Antigen-specific B cell receptor sensitizes B cells to infection by influenza virus (2013) (60)
Transnuclear Mice with Predefined T Cell Receptor Specificities Against Toxoplasma gondii Obtained via SCNT (2010) (60)
The putative Drosophila methyltransferase gene dDnmt2 is contained in a transposon-like element and is expressed specifically in ovaries (2000) (59)
DNA replication of SV40-infected cells. VII. Formation of SV40 catenated and circular dimers. (1973) (59)
Resource One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR / Cas-MediatedGenomeEngineering (2013) (59)
Beta 2-microglobulin deficient mice lack CD4-8+ cytolytic T cells. 1990. (2010) (58)
High frequency of unequal recombination in pseudoautosomal region shown by proviral insertion in transgenic mouse (1986) (58)
Migration and proliferation of cultured neural crest cells in W mutant neural crest chimeras. (1991) (58)
Tet 1 Is Dispensable for Maintaining Pluripotency and Its Loss Is Compatible with Embryonic and Postnatal Development (2011) (58)
Germ line integration of moloney leukemia virus: Effect of homozygosity at the M-MuLV locus (1977) (58)
Systematic Identification of Culture Conditions for Induction and Maintenance of Naive Human Pluripotency (2014) (57)
Small-molecule enhancers of autophagy modulate cellular disease phenotypes suggested by human genetics (2015) (56)
Chromosomal position and specific demethylation in enhancer sequences of germ line-transmitted retroviral genomes during mouse development (1985) (55)
Intravital imaging of mouse embryos (2020) (55)
Cloning of Two Genetically Transmitted Moloney Leukemia Proviral Genomes: Correlation Between Biological Activity of the Cloned DNA and Viral Genome Activation in the Animal (1982) (55)
Pan-Src family kinase inhibitors replace Sox2 during the direct reprogramming of somatic cells. (2011) (55)
Severe peripheral sensory neuron loss and modest motor neuron reduction in mice with combined deficiency of brain‐derived neurotrophic factor, neurotrophin 3 and neurotrophin 4/5 (2000) (55)
Gene targeting in human pluripotent cells. (2010) (54)
Stimulation of the collagen α1(I) endogenous gene and transgene in carbon tetrachloride–induced hepatic fibrosis (1993) (54)
Mechanisms of gene regulation in human embryos and pluripotent stem cells (2017) (54)
Dynamic Enhancer DNA Methylation as Basis for Transcriptional and Cellular Heterogeneity of ESCs. (2019) (53)
DNA CpG hypomethylation induces heterochromatin reorganization involving the histone variant macroH2A (2005) (53)
Blimp1 Expression Predicts Embryonic Stem Cell Development In Vitro (2011) (53)
SCNT-derived ESCs with mismatched mitochondria trigger an immune response in allogeneic hosts. (2015) (52)
The integration sites of endogenous and exogenous Moloney murine leukemia virus (1979) (52)
Reduction in the number of spinal motor neurons in neurotrophin-3-deficient mice (1995) (52)
A Gene-Targeting Approach Identifies a Function for the First Intron in Expression of the α1(I) Collagen Gene (1998) (52)
DNA replication in SV40-infected cells. V. Circular and catenated oligomers of SV40 DNA. (1972) (51)
X chromosome choice occurs independently of asynchronous replication timing (2005) (51)
Direct Lineage Conversion of Adult Mouse Liver Cells and B Lymphocytes to Neural Stem Cells (2014) (51)
Low-multiplicity infection of Moloney murine leukemia virus in mouse cells: effect on number of viral DNA copies and virus production in producer cells (1978) (50)
Dnmt3a Protects Active Chromosome Domains against Cancer-Associated Hypomethylation (2012) (50)
The role of GABAergic signalling in neurodevelopmental disorders (2021) (49)
Generating iPS cells from MEFS through forced expression of Sox-2, Oct-4, c-Myc, and Klf4. (2008) (49)
T-cell receptor-driven lymphomagenesis in mice derived from a reprogrammed T cell (2010) (48)
DNA Methylation by DNA Methyltransferase 1 Is Critical for Effector CD8 T Cell Expansion1 (2006) (48)
Increase of AKR-specific sequences in tumor tissues of leukemic AKR mice. (1976) (48)
Human neural crest cells contribute to coat pigmentation in interspecies chimeras after in utero injection into mouse embryos (2016) (48)
Construction and properties of replication-competent murine retroviral vectors encoding methotrexate resistance (1989) (47)
Tet1 and Tet2 Protect DNA Methylation Canyons against Hypermethylation (2015) (46)
The ras and myc oncogenes cooperate in tumor induction in many tissues when introduced into midgestation mouse embryos by retroviral vectors. (1989) (46)
Human physiomimetic model integrating microphysiological systems of the gut, liver, and brain for studies of neurodegenerative diseases (2021) (45)
Direct in vivo VH to JH rearrangement violating the 12/23 rule (2005) (45)
Introduction of the human pro alpha 1(I) collagen gene into pro alpha 1(I)-deficient Mov-13 mouse cells leads to formation of functional mouse-human hybrid type I collagen. (1987) (43)
Major Histocompatibility Complex Class I Deficiency Prolongs Islet Allograft Survival (1993) (42)
Involvement of the cell cycle-regulated nuclear factor HiNF-D in cell growth control of a human H4 histone gene during hepatic development in transgenic mice. (1991) (42)
Conformation of free and of integrated Moloney leukemia virus proviral DNA in preleukemic and leukemic BALB/Mo mice. (1980) (42)
Failure to replicate the STAP cell phenomenon (2015) (42)
Molecular analysis of the Mov 34 mutation: transcript disrupted by proviral integration in mice is conserved in Drosophila. (1990) (41)
IgG1+ ovalbumin-specific B-cell transnuclear mice show class switch recombination in rare allelically included B cells (2012) (41)
Formation of a full complement of cranial proprioceptors requires multiple neurotrophins (2000) (41)
V(D)J recombination is not activated by demethylation of the kappa locus. (2000) (41)
Tumor suppressor functions of Dnmt3a and Dnmt3b in the prevention of malignant mouse lymphopoiesis (2014) (40)
Tet1 in Nucleus Accumbens Opposes Depression- and Anxiety-Like Behaviors. (2017) (40)
TGFβ-induced epigenetic deregulation of SOCS3 facilitates STAT3-signaling to promote fibrosis. (2020) (40)
DNA methylation, retroviruses, and embryogenesis (1982) (40)
Wt1 functions in the development of germ cells in addition to somatic cell lineages of the testis. (2004) (40)
Transnuclear TRP1-Specific CD8 T Cells with High or Low Affinity TCRs Show Equivalent Antitumor Activity (2013) (40)
Epigenetic Hierarchy Governing Nestin Expression (2009) (39)
Germ line integration of Moloney leukemia virus: identification of the chromosomal integration site. (1979) (39)
Oncogenes in transgenic mice. (1988) (39)
Oncornavirus gene expression during embryonal development of the mouse. (1977) (39)
Reprogramming of somatic cell identity. (2008) (39)
Molecular complementation of a collagen mutation in mammalian cells using yeast artificial chromosomes. (1992) (39)
Nuclear cloning, epigenetic reprogramming and cellular differentiation. (2005) (38)
Sequence-specific methylation of the mouse H19 gene in embryonic cells deficient in the Dnmt-1 gene. (1998) (38)
Optical Imaging of a Tactile Illusion in Area 3 b of the Primary Somatosensory Cortex (38)
Cell-Specific TLR9 Trafficking in Primary APCs of Transgenic TLR9-GFP Mice (2013) (37)
SARS-CoV-2 RNA reverse-transcribed and integrated into the human genome (2020) (36)
SMARCE1 is required for the invasive progression of in situ cancers (2017) (36)
Retrovirus activation in embryonal carcinoma cells by cellular promoters. (1989) (36)
Oct 4 Expression Is Not Required for Mouse Somatic Stem Cell Self-Renewal (35)
Insertion of retrovirus into the first intron of al(I) collagen gene leads to embryonic lethal mutation in mice (34)
Retroviruses and insertional mutagenesis. (1985) (34)
Generation of pigmented stripes in albino mice by retroviral marking of neural crest melanoblasts. (1991) (34)
Matched Developmental Timing of Donor Cells with the Host Is Crucial for Chimera Formation (2018) (33)
Whole chromosome loss and genomic instability in mouse embryos after CRISPR-Cas9 genome editing (2021) (33)
A method for high efficiency YAC lipofection into murine embryonic stem cells. (1996) (32)
Neurotrophin-3 Promotes Cell Death Induced in Cerebral Ischemia, Oxygen-Glucose Deprivation, and Oxidative Stress: Possible Involvement of Oxygen Free Radicals (2002) (31)
Maternal transmission of retroviral disease and strategies for preventing infection of the neonate (1989) (31)
Neurotrophin-3 modulates noradrenergic neuron function and opiate withdrawal (2001) (31)
Replication of the Small Coliphage M13: Evidence for Long-living M13 Specific Messenger RNA (1970) (31)
Derivation and manipulation of murine embryonic stem cells. (2009) (31)
Hybrid Embryonic Stem Cell-Derived Tetraploid Mice Show Apparently Normal Morphological, Physiological, and Neurological Characteristics (2003) (31)
Chapter 5 Target derived and putative local actions of neurotrophins in the peripheral nervous system (1994) (30)
Establishment of human pluripotent stem cell-derived pancreatic β-like cells in the mouse pancreas (2018) (30)
Endogenous Moloney leukemia virus in nonviremic Mov substrains of mice carries defects in the proviral genome (1983) (30)
Development : genetics, epigenetics, and environmental regulation (1999) (30)
Retrovirus-induced insertional mutagenesis: mechanism of collagen mutation in Mov13 mice (1991) (29)
Matrix Remodeling Maintains Embryonic Stem Cell Self‐Renewal by Activating Stat3 (2013) (29)
Endogenous retroviruses lead to the expression of a histocompatibility antigen detectable by skin graft rejection. (1987) (29)
Differentiation of F1 embryonic stem cells into viable male and female mice by tetraploid embryo complementation. (2003) (28)
Passive immunotherapy prevents expression of endogenous Moloney virus and amplification of proviral DNA in BALB/Mo mice. (1980) (28)
Uber infektiöse Substrukturen aus Escherichia coli Bakteriophagen. VIII. On the tertiary structure and biological properties of phiX174 replicative form. (1966) (28)
X chromosome-linked transmission and expression of retroviral genomes microinjected into mouse zygotes. (1983) (28)
Expression of oncogenic K-ras from its endogenous promoter leads to a partial block of erythroid differentiation and hyperactivation of cytokine-dependent signaling pathways. (2007) (28)
Editing the Epigenome to Tackle Brain Disorders (2019) (27)
Building Capacity for a Global Genome Editing Observatory: Conceptual Challenges. (2018) (27)
Nuclear cloning, epigenetic reprogramming, and cellular differentiation. (2004) (27)
Structure and chromosomal mapping of a highly polymorphic repetitive DNA sequence from the pseudoautosomal region of the mouse sex chromosomes. (1990) (27)
Microcephaly Modeling of Kinetochore Mutation Reveals a Brain-Specific Phenotype (2018) (26)
Proviral inactivation of the Npat gene of Mpv 20 mice results in early embryonic arrest (1997) (26)
Parent-of-Origin DNA Methylation Dynamics during Mouse Development. (2016) (26)
Stem cells, pluripotency and nuclear reprogramming (2009) (26)
Position-Dependent Silencing of Germline Vβ Segments on TCRβ Alleles Containing Preassembled VβDJβCβ1 Genes (2010) (26)
Chromosomal mapping of four different integration sites of Moloney murine leukemia virus including the locus for alpha 1(I) collagen in mouse. (1986) (26)
Maternal transmission of retroviral disease: transgenic mice as a rapid test system for evaluating perinatal and transplacental antiretroviral therapy. (1988) (25)
Isolation of circular DNA by zonal centrifugation. Separation of normallength, double length and catenated M13 replicative form DNA and of host specific "episomal" DNA. (1969) (25)
Formation of Human Neuroblastoma in Mouse-Human Neural Crest Chimeras. (2020) (25)
Corrigendum: Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation (2015) (25)
Evidence for SV40 specific RNA containing virus and host specific sequences. (1972) (24)
Infectious Nucleic Acids of Escherichia coli Bacteriophages (1967) (24)
Chromatin Conformation of Integrated Moloney Leukemia Virus DNA Sequences in Tissues of BALB/Mo Mice and in Virus-Infected Cell Lines (1980) (24)
On the cloning of animals from terminally differentiated cells (2007) (23)
Developmental biology. Don't clone humans! (2001) (23)
An X-linked human collagen transgene escapes X inactivation in a subset of cells. (1992) (22)
A stochastic model dissects cell states in biological transition processes (2014) (22)
Retroviral transduction of the human c-Ha-ras-1 oncogene into midgestation mouse embryos promotes rapid epithelial hyperplasia (1989) (22)
Nuclear cloning and direct reprogramming: the long and the short path to Stockholm. (2012) (22)
Building Capacity for a Global Genome Editing Observatory: Institutional Design. (2018) (21)
Normal eye-specific patterning of retinal inputs to murine subcortical visual nuclei in the absence of brain-derived neurotrophic factor (2005) (21)
Partial FMRP expression is sufficient to normalize neuronal hyperactivity in Fragile X neurons (2019) (21)
The murine Mov-34 gene: full-length cDNA and genomic organization. (1991) (21)
Neurotrophin‐3 and trkC in muscle are non‐essential for the development of mouse muscle spindles (1998) (20)
Mammalian X chromosome inactivation. (1998) (20)
Susceptibility of type I collagen containing mutated alpha 1(1) chains to cleavage by human neutrophil collagenase. (1993) (20)
CD8(+) T cells from mice transnuclear for a TCR that recognizes a single H-2K(b)-restricted MHV68 epitope derived from gB-ORF8 help control infection. (2012) (19)
CNS disease models with human pluripotent stem cells in the CRISPR age. (2016) (19)
Transcriptionally Profiling Cells Sorted by Transcript Abundance (2014) (19)
Infection of mouse blastocysts with SV40 DNA: normal development of the infected embryos and persistence of SV40-specific DNA sequences in the adult animals. (1975) (19)
DNA replication in SV40-infected cells. VI. The effect of cycloheximide on the formation of SV40 oligomeric DNA. (1972) (19)
Nuclear Cloning and Epigenetic Reprogramming (2004) (19)
TCRβ Feedback Signals Inhibit the Coupling of Recombinationally Accessible Vβ14 Segments with DJβ Complexes (2009) (18)
Alternative SET/TAFI Promoters Regulate Embryonic Stem Cell Differentiation (2017) (18)
Virus-specific transcription and translation in organs of BALB/Mo mice: comparative study using quantitative hybridization, in situ hybridization, and immunocytochemistry. (1982) (18)
Rescue of type I collagen-deficient phenotype by retroviral-vector-mediated transfer of human pro alpha 1(I) collagen gene into Mov-13 cells (1987) (18)
Analysis of 3'-azido-3'-deoxythymidine levels in tissues and milk by isocratic high-performance liquid chromatography. (1990) (18)
Genetic manipulation of the early mammalian embryo (1985) (18)
Transgene Excision Has No Impact on In Vivo Integration of Human iPS Derived Neural Precursors (2011) (18)
Human Embryo Editing: Opportunities and Importance of Transnational Cooperation. (2017) (17)
Interview with Rudolf Jaenisch, M.D. (2008) (17)
An Endogenously Tagged Fluorescent Fusion Protein Library in Mouse Embryonic Stem Cells (2017) (17)
Figures and figure supplements Control of TSC 2-Rheb signaling axis by arginine regulates mTORC 1 activity (2016) (17)
Restarting stalled autophagy a potential therapeutic approach for the lipid storage disorder, Niemann-Pick type C1 disease (2014) (17)
Expression of Xist RNA is sufficient to initiate macrochromatin body formation (2001) (16)
Transdifferentiation by defined factors as a powerful research tool to address basic biological questions (2012) (16)
Combined Loss of Tet1 and Tet2 Promotes B-Cell, but Not Myeloid Malignancies in Mice (2015) (16)
Infectivity and structure of molecular clones obtained from two genetically transmitted Moloney leukemia proviral genomes. (1982) (16)
Transcription of endogenous C-type viruses in resting and proliferating tissues of BALB/Mo mice. (1979) (16)
Skin Graft Rejection by 132-microglobulin- deficient Mice By Maarten Zijlstra,* Hugh Auchincloss, Jr.,~ Janet M. Loring,* (1992) (15)
Conformation of Moloney murine leukaemia proviral sequences in chromatin from leukaemic and nonleukaemic cells (1979) (15)
Stroke Damage in Mice after Knocking the Neutrophin-4 Gene into the Brain-Derived Neurotrophic Factor Locus (2003) (15)
Commentary: Isolated Stem Cells—Patentable as Cultural Artifacts? (2007) (15)
Target derived and putative local actions of neurotrophins in the peripheral nervous system. (1994) (15)
Dose-dependent roles for canonical Wnt signalling in de novo crypt formation and cell cycle properties of the colonic epithelium (2013) (15)
Politically correct human embryonic stem cells? (2006) (15)
Differentiation and virus expression in BALB/Mo mice: endogenous Moloney leukemia virus is not activated in hematopoietic cells. (1982) (14)
A role for p75 receptor in neurotrophin-3 functioning during the development of limb proprioception (1999) (14)
Probing the signaling requirements for naive human pluripotency by high-throughput chemical screening (2021) (14)
Experimental manipulation of genomic methylation. (1996) (14)
Transfer of a mutant dihydrofolate reductase gene into pre- and postimplantation mouse embryos by a replication-competent retrovirus vector (1989) (13)
Chapter 4 – Germ Line Integration and Mendelian Transmission of Exogenous Type C Viruses (1980) (13)
Flp recombinase regulated lacZ expression at the ROSA26 locus (2002) (13)
Infection of primary African green monkey cells with SV40 monomeric and dimeric DNA. (1971) (13)
Human cerebral organoids reveal deficits in neurogenesis and neuronal migration in MeCP2-deficient neural progenitors (2018) (13)
One-step generation of monoclonal B cell receptor mice capable of isotype switching and somatic hypermutation (2018) (12)
Utility of C57BL/6J × 129/SvJae embryonic stem cells for generating chromosomal deletions: tolerance to γ radiation and microsatellite polymorphism (1998) (12)
Uber infektiöse Substrukturen aus Bakteriophagen. VI. A simple method for separating the replicative form from single-stranded phiX174 DNA. (1966) (12)
DNase I sensitivity of endogenous and exogenous proviral genome copies in M-MuLV-induced tumors of Mov-3 Mice. (1982) (12)
Collagen synthesis by cell lines derived from Mov-13 mouse embryos which have a lethal mutation in the collagen alpha 1(I) gene. (1987) (12)
Functional analysis of CX3CR1 in human induced pluripotent stem (iPS) cell‐derived microglia‐like cells (2020) (11)
Infection of developing mouse embryos with murine leukemia virus: tissue specificity and genetic transmission of the virus. (1976) (11)
Whsc1 links pluripotency exit with mesendoderm specification (2019) (11)
Metastable Pluripotent States in NOD Mouse Derived ES Cells (2009) (11)
Transnuclear mice with pre-defined T cell receptor specificities against Toxoplasma gondii obtained via SCNT. (2010) (10)
Cytotoxic Escherichia coli strains encoding colibactin isolated from immunocompromised mice with urosepsis and meningitis (2018) (10)
Transplacental Antiretroviral Therapy with 9-(2‐Phosphonylmethoxyethyl)adenine Is Embryotoxic in Transgenic Mice (1991) (10)
Infection by polyomavirus of murine cells deficient in class I major histocompatibility complex expression (1992) (10)
Human T Cells Expressing a CD19 CAR-T Receptor Provide Insights into Mechanisms of Human CD19-Positive β Cell Destruction (2020) (10)
Control of gamma delta T-cell development. (1991) (10)
Genetic transmission of Moloney leukemia virus: mapping of the chromosomal integration site. (1979) (9)
Retroviruses and mouse embryos: a model system in which to study gene expression in development and differentiation. (1983) (9)
OCT4 cooperates with distinct ATP-dependent chromatin remodelers in naïve and primed pluripotent states in human (2021) (9)
Engineered tissues and strategies to overcome challenges in drug development (2020) (9)
Retroviruses and embryogenesis: de novo methylation activity involved in gene expression. (1983) (9)
Telomerase expression marks transitional growth‐associated skeletal progenitor/stem cells (2021) (8)
Erratum: HIF-1α is essential for myeloid cell-mediated inflammation (Cell 112:5 (648)) (2003) (8)
Replication of the single-stranded DNA bacteriophage M 13. On the transcription in vivo of the M 13 replicative-form DNA. (1973) (8)
Erratum: TET1 is a tumor suppressor of hematopoietic malignancy (2015) (8)
Dissecting risk haplotypes in sporadic Alzheimer's disease. (2015) (8)
Strategies to induce nuclear reprogramming. (2006) (8)
Monitoring Dynamics of DNA Methylation at Single-Cell Resolution during Development and Disease. (2015) (8)
Effects of murine leukemia virus infection on long-term hematopoiesis in vitro emphasized by increased survival of bone marrow cultures derived from BALB/Mo mice. (1981) (8)
YAP1 Increases Organ Size and Expands Undifferentiated Progenitor Cells (2007) (8)
Autophagy promotes cell survival by maintaining NAD levels. (2021) (7)
Response to Comment on "Chromosomal Instability and Tumors Promoted by DNA Hypomethylation" and "Induction of Tumors in Mice by Genomic Hypomethylation" (2003) (7)
Response to Parry et al.: Strong evidence for genomic integration of SARS-CoV-2 sequences and expression in patient tissues (2021) (7)
Highly inducible cell lines derived from mice genetically transmitting the Moloney murine leukemia virus genome (1979) (7)
Nuclear cloning, embryonic stem cells, and transplantation therapy. (2002) (7)
Air-liquid interface culture promotes maturation and allows environmental exposure of pluripotent stem cell–derived alveolar epithelium (2022) (7)
GERM LINE INTEGRATION AND LEUKEMOGENESIS OF EXOGENOUS AND ENDOGENOUS MURINE LEUKEMIA VIRUSES (1976) (6)
Cellular transcripts encoded at a locus which permits retrovirus expression in mouse embryonic cells. (1991) (6)
Activation of endogenous retroviral genomes in Mov strains of mice. (1987) (6)
Human Intestinal Tissue with Adult Stem Cell Properties Derived from Pluripotent Stem Cells (2014) (6)
A strategy for rapid production and screening of yeast artificial chromosome libraries (2004) (6)
Correction for Blelloch et al., Inaugural Article: Nuclear cloning of embryonal carcinoma cells, PNAS 2004 101:13985-13990 (2004) (6)
Development of a physiological insulin resistance model in human stem cell–derived adipocytes (2022) (6)
Supplemental Data Core Transcriptional Regulatory Circuitry in Human Embryonic Stem Cells (2005) (6)
Cell lineage as a predictor of immune response in neuroblastoma (2021) (6)
Non-H-2 histocompatibility antigens encoded by Moloney-murine leukemia virus in Mov mouse strains are detectable by skin grafting and cytolytic T lymphocytes. (1988) (6)
Nuclear Reprogramming: Biological and Technological Constraints (2002) (5)
JIP2 haploinsufficiency contributes to neurodevelopmental abnormalities in human pluripotent stem cell–derived neural progenitors and cortical neurons (2018) (5)
A brief review of genome editing technology for generating animal models (2020) (5)
Retroviruses as tools for mammalian development. (1986) (5)
Site-directed mutagenesis of type I collagen: effect on susceptibility to collagenase. (1992) (5)
16pdel lipid changes in iPSC-derived neurons and function of FAM57B in lipid metabolism and synaptogenesis (2021) (5)
The Study of Collagen Structure and Function by Site‐Directed Mutagenesis of Collagen Genes a (1990) (5)
Generation of embryonic stem (ES) cell-derived embryos and mice by tetraploid-embryo complementation. (2006) (4)
Matrix Remodeling Maintains ESC Self-Renewal by Activating Stat3 (2013) (4)
Genome Editing in Neurosciences (2017) (4)
Effect of DNA hypomethylation on neural control of respiration: a genetic model. (2001) (4)
New insights into the molecular pathology of osteogenesis imperfecta. (1989) (4)
Targeted Inactivation of the Muscle Regulatory Genes Myf-5 and MyoD: Effect on Muscle and Skeletal Development (1993) (4)
Micromanipulating dosage compensation: understanding X-chromosome inactivation through nuclear transplantation. (2003) (4)
Endogenous retroviruses (1983) (4)
Sixteenth Annual Pezcoller Symposium (2004) (4)
An American scientist in Tehran (2007) (4)
Collagen Protein Abnormalities Produced by Site-Directed Mutagenesis of the Proal(I) Gene (1989) (4)
The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes. (2022) (4)
Sixteenth Annual Pezcoller Symposium: Stem Cells and Epigenesis in Cancer (2004) (3)
Erratum: Human intestinal tissue with adult stem cell properties derived from pluripotent stem cells (Stem Cell Reports (2014) 2 (838-852)) (2014) (3)
TCRb Feedback Signals Inhibit the Coupling of Recombinationally Accessible Vb14 Segments with DJb Complexes (2009) (3)
Mesenchymal and adrenergic cell lineage states in neuroblastoma possess distinct immunogenic phenotypes (2022) (3)
Retroviruses and embryogenesis, Seventh Adolf Butenandt Lecture given to the Gesellschaft für Biologische Chemie in Damp 2000 on September 29, 1982. (1982) (3)
Cloning The Laboratory Mouse by Nuclear Transfer (2006) (3)
Pillars Article: β2-Microglobulin Deficient Mice Lack CD4−8+ Cytolytic T Cells. Nature. 1990. 344: 742–746 (2010) (3)
Isolation of functional MHC class I-deficient islet cells. (1993) (3)
Principles of Cloning: Second Edition (2013) (3)
Tumorviruses, neoplastic transformation and differentiation. (2011) (3)
Genomic sequence of mouse COL1A1 encoding the collagen propeptides. (1993) (3)
Transnuclear TRP 1-specific CD 8 T cells with high or low affinity TCRs show equivalent anti-tumor activity (2014) (3)
Expression of retroviruses during early mouse embryogenesis. (1983) (3)
In Vitro Modeling of Complex Neurological Diseases (2017) (3)
Developmental Mutations Generated by Retroviral Insertional Mutagenesis (1992) (2)
Response to “Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation” (2021) (2)
SARS-CoV-2 infection of human pluripotent stem cell-derived liver organoids reveals potential mechanisms of liver pathology (2022) (2)
Transcriptional profiling of cells sorted by transcript abundance (2014) (2)
Isolation of Simian Virus 40 Recombinants from Cells Infected with Oligomeric Forms of Simian Virus 40 Deoxyribonucleic Acid (1972) (2)
Erratum: Nuclear cloning of embryonal carcinoma cells (Proceedings of the National Academy of Sciences of the United States of America (September 28, 2004) 101:39 (13985-13990)) (2004) (2)
CRISPR/Cas9-Mediated Knockin and Knockout in Zebrafish -- Genome Editing in Neurosciences (2017) (2)
Tunable Conductive Hydrogel Scaffolds for Neural Cell Differentiation (2022) (2)
DERIVATION OF THREE MOUSE STRAINS CARRYING MOLONEY LEUKEMIA VIRUS IN THEIR GERM LINE AT DIFFERENT GENETIC LOCI (1980) (2)
Multiplex Epigenome Editing of MECP2 to Rescue Rett Syndrome Neurons (2022) (2)
Different Roles for Tet1 and Tet2 Proteins in Reprogramming-Mediated Erasure of Imprints Induced by EGC Fusion (2013) (2)
NAD depletion mediates cytotoxicity in human neurons with autophagy deficiency. (2023) (2)
RNA and the Epigenetic Minireview Regulation of X Chromosome Inactivation (1998) (2)
STUDYING REPROGRAMMING OF SOMATIC CELLS VIA FUSION WITH EMBRYONIC STEM CELLS : A MASSIVELY PARALLEL DEVICE FOR CELL FUSION (2007) (2)
A Short DNA Methyltransferase Isoform Restores Methylation (1998) (2)
Reply to Briggs et al.: Genomic integration and expression of SARS-CoV-2 sequences can explain prolonged or recurrent viral RNA detection (2021) (2)
The Ethics of Inheritable Genetic Modification: Nuclear cloning, embryonic stem cells, and gene transfer (2006) (2)
iPS Cell Technology and Disease Research: Issues To Be Resolved (2013) (2)
Expression of oncogenic Kras from its endogenous promoter leads to a partial block of erythroid differentiation and hyperactivation of cytokine-dependent signaling pathways (2007) (2)
Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors (2009) (2)
Epigenetic reprogramming and nuclear transfer From frog cloning to customized human embryonic stem cells (2006) (1)
Stem Cells in Translation (2013) (1)
Celebrating 10 years of hESC lines: an interview with Rudolf Jaenisch. (2008) (1)
The dynamic clustering of insulin receptor underlies its signaling and is disrupted in insulin resistance (2022) (1)
Corrigendum: Failure to replicate the STAP cell phenomenon (2015) (1)
Transdifferentiation and adult stem cells: Myth or reality? (2004) (1)
Role of Epigenetics (DNA Methylation) in RPE and Photoreceptor Development (2010) (1)
Early Development of the Muscle Spindle and its Dependence on Neurotrophic Factors (1995) (1)
Fragile X Syndrome Patient–Derived Neurons Developing in the Mouse Brain Show FMR1-Dependent Phenotypes (2021) (1)
Mitochondrial Proteins Possess Antigenicity and Can Cause Rejection (2016) (1)
Stem Cell Research: Promise and Progress (2015) (1)
Direct Reprogramming of Somatic Cells to a Pluripotent State (2009) (1)
FAM57B is a modulator of ceramide synthesis that regulates sphingolipid homeostasis and synaptic composition in the developing brain (2021) (1)
The Role of Dnmt1 in Retinal Differentiation (2011) (1)
factors and The MyoD family of transcription skeletal myogenesis (1995) (1)
Single-cell analysis reveals that expression of Nanog is biallelic and equally variable as that of other pluripotency factors in mouse embryonic stem cells (2014) (1)
Rett Syndrome astrocytes disrupt neuronal activity and cerebral organoid development through transfer of dysfunctional mitochondria (2023) (1)
Early Lineage Bifurcation during Differentiation of Embryonic Stem Cells Revealed by Single-Cell Transcriptomics (2015) (1)
Development of Human Neuroblastomas in Mouse-Human Neural Crest Chimeras (2019) (1)
Position-Dependent Silencing of Germline V beta Segments on TCR beta Alleles Containing Preassembled V beta DJ beta C beta 1 Genes (2010) (1)
Mechanisms and models of somatic cell reprogramming Citation (2014) (1)
Chromosomal Position andSpecific Demethylation inEnhancer Sequences ofGermLine-Transmitted Retroviral GenomesDuring MouseDevelopment (1985) (1)
Neuroscience Research Using Non-human Primate Models and Genome Editing -- Genome Editing in Neurosciences (2017) (1)
Chromatin Structure and Gene Expression Programs of Human Embryonic and Induced Pluripotent Stem Cells Citation (2010) (1)
A Possible Role Of Microglia In Zika Virus Infection Of The Fetal Human Brain (2017) (1)
Retroviral spongiform degenerative disease produced by the murine neurotropic retrovirus Cas-Br-E. (1993) (1)
A stochastic model dissects cellular states and heterogeneity in transition processes (2014) (1)
Abstract B67: The DLK1-DIO3 imprinted region regulates long-term proliferation in normal and malignant breast epithelium (2018) (0)
RescueofTypeICollagen-Deficient Phenotype byRetroviral- Vector-Mediated Transfer ofHumanprocl(I) Collagen Geneinto Mov-13Cells (1987) (0)
Abstract B59: Transnuclear mice as models of the immune response to pancreatic cancer (2015) (0)
Dynamics of lineage commitment revealed by single-cell transcriptomics of differentiating embryonic stem cells (2017) (0)
330 Regenerative Therapy after Myocardial Infarction: Role of mtDNA in SCNT Derived Embryonic Stem Cells (2012) (0)
Human-mouse chimeric Fragile X syndrome model reveals FMR1-dependent neuronal phenotypes (2020) (0)
A conversation with Rudolf Jaenisch. (2015) (0)
Abstract B24: Delineating the roles of lysine 27 methylation-associated epigenetic modulators in T cell leukemia. (2015) (0)
Induction of Expansion an d Folding in Human Cerebral Organoids Graphical (0)
Mutations in Transgenic Mice (1989) (0)
Starting signal: Aberrant kinase activation as a trigger for SARS-CoV-2 induced axonal damage (2022) (0)
2 The Role of Polycomb Group Proteins in the Maintenance of Embryonic Stem Cell Pluripotency (2006) (0)
Isogenic iPSC-derived models of disease (2013) (0)
Fibroblasts-derived from Pluripotent Cells Harboring a Single Allele Knockout in Two Pluripotency Genes Exhibit DNA Methylation Abnormalities and pluripotency induction Defects (2022) (0)
Genetic and Epigenetic Analysis of Human Embryonic Stem Cell (2007) (0)
Corrigendum to “a role for p75 receptor in neurotrophin-3 functioning during the development of limb proprioception” [Neuroscience 90 (1) 259–268] (2003) (0)
[Various aspects in the long-term planning of infectious disease wards in the DDR]. (1975) (0)
ヒトI型プロコラーゲンのプレプロα1(I)鎖に対する完全長cDNAクローンの構造 (1988) (0)
Yeun Chung Derived Neurons − Patient-Synuclein Toxicity in Parkinson α Identification and Rescue (2016) (0)
A method for culturing non-human mammalian animals (2001) (0)
The cloning of mammals: what are the problems? (2003) (0)
Resource Optimal-Transport Analysis of Single-Cell Gene Expression Identifies Developmental Trajectories in Reprogramming Graphical (0)
Animal virus genetics : proceedings of the 1980 ICN-UCLA Symposia on Animal Virus Genetics held in Keystone, Colo., March 9-14, 1980 (1980) (0)
Role of Epigenetics (DNA Methylation) in Retinal Differentiation (2009) (0)
Document S1. Supplemental Experimental Procedures and Figures S1 and S2 (2013) (0)
An Oncogene-Regulated Epigenetic Switch in T Cell Acute Lymphoblastic Leukemia (2014) (0)
Roadmaps of epigenetic reprogramming : surface markers and reporter genes (2014) (0)
Beatrice Mintz, a giant in mammalian development (2022) (0)
from allogeneic donors Towards eliminating HLA class I expression to generate universal cells (2013) (0)
Correction: Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity (2020) (0)
Formation of a full complement of cranial proprioceptors requires multiple neurotrophins (2002) (0)
Genome-Wide Genetic Screening in the Mammalian CNS -- Genome Editing in Neurosciences (2017) (0)
Human embryonic stem cells with biological and epigenetic to those of mouse ESCs (2010) (0)
#33: Single-cell RNA sequencing analysis of Zika virus infection in human stem cell-derived neuroprogenitor cells and cerebral organoids (2021) (0)
NUCLEAR CLONING , EMBRYONIC STEM CELLS AND THE PROMISE FOR TRANSPLANTATION THERAPY (2013) (0)
Genome Editing in Neuroscinces (2017) (0)
Resource An Endogenously Tagged Fluorescent Fusion Protein Library in Mouse Embryonic Stem Cells (2017) (0)
#71: Single-cell RNA Sequencing Analysis of Zika Virus Infection in Human Stem Cell-Derived Neuroprogenitor Cells and Cerebral Organoids (2021) (0)
Protein Labelling Using Alkyne– Azide Methodology Quantifying the Polar Wind (0)
LINE1-Mediated Reverse Transcription and Genomic Integration of SARS-CoV-2 mRNA Detected in Virus-Infected but Not in Viral mRNA-Transfected Cells (2023) (0)
Jacob Hanna , iPS Cells Generated from Autologous Skin Treatment of Sickle Cell Anemia Mouse (2008) (0)
Abstract A07: Characterizing the specific oncogenic and tumor suppressor roles of H3K27me3 epigenetic modulators in T cell leukemia (2013) (0)
One-step generation of monoclonal B cell receptor mice capable of class switch recombination and somatic hypermutation (2017) (0)
Table of Contents (1992) (0)
Parent-of-Origin DNA Met hylation Dynamics during Mouse Development Graphical (2016) (0)
Introduction of the human proal ( I ) collagen gene into proal ( I )-deficient Mov 413 mouse cells leads to formation of functional mousehuman hybrid type I collagen ( osteogenesis imperfecta / human-mouse collagen heterotrimer ) (0)
Requirement for Neurotrophin-3 in the Development of the Muscle Proprioceptive System (1995) (0)
New Wilms' tumour suppressor gene (WT1) functions revealed by YAC transgenic analysis (1998) (0)
Problems in Differentiation Pathways and Cellular Targets for Leukemogens Group Report (1985) (0)
Samples Symposium Ceremony (2003) (0)
Abstract A08: Divergent tumor cell states in neuroblastoma possess distinct immunogenic phenotypes (2022) (0)
Stem Cell Society Singapore Symposium 2013 " Early Human Development & Fetal-maternal Medicine" (2013) (0)
Multiscale Genome Engineering: Genome-Wide Screens and Targeted Approaches -- Genome Editing in Neurosciences (2017) (0)
Normal development and growth of mice carrying a targeted disruption of the al retinoic acid receptor gene (homologous recombination/gene targeting) (2016) (0)
Brief report Expression of oncogenic K-ras from its endogenous promoter leads to a partial block of erythroid differentiation and hyperactivation of cytokine-dependent signaling pathways (2007) (0)
Stimulation of the Wnt pathway in reprogramming somatic cells (2008) (0)
Human tissue with adult stem cell properties derived from pluripotent stem cells. (2014) (0)
Immunobiology of SCNT Derived Embryonic Stem Cells: Pivotal Role of mtDNA in Rejection of Transplanted Stem Cells: 2141 (2012) (0)
Infection byPolyomavirus ofMurineCells Deficient inClassI MajorHistocompatibili ty ComplexExpressiont (1992) (0)
Human iPS cell-derived sensory neurons can be infected by SARS-CoV-2 strain WA1/2020 as well as variants delta and omicron (2023) (0)
Konrad Hochedlinger: ISSCR Outstanding Young Investigator for 2009 (2009) (0)
hromosomal Position or Virus Mutation Per Expression in Embryonal Carcinom ells (1986) (0)
Immunobiology of embryonic stem cells: Foreign mtDNA as an immunological barrier in SCNT derived embryonic stem cells transplantation (2013) (0)
Corrigendum: Hallmarks of pluripotency (2015) (0)
Transcription of cloned Moloney murine leukemia proviral DNA injected into Xenopus laevis oocytes. (1983) (0)
JIP2 haploinsufficiency contributes to neurodevelopmental abnormalities in human pluripotent stem cell-derived neural progenitors and cortical neurons (2017) (0)
Running title: HLA-A disruption in donor cells (2017) (0)
Webinar | Generating CRISPR mouse models: Challenges and solutions (2017) (0)
Molecular Dopamine Transporter Efflux in ADHD (2008) (0)
Chung Derived Neurons − Patient-Synuclein Toxicity in Parkinson α Identification and Rescue of (2014) (0)
Results Mice Carrying a Colla-1 Transgene with Mutations at the Collagenase Cleavage Site Die During Late Gestation (2002) (0)
CD 8 [ superscript + ] T Cells from Mice Transnuclear for a TCR that Recognizes a Single H-2 K [ superscript b ]-Restricted MHV 68 Epitope Derived from gB-ORF 8 Help (2012) (0)
Differentiation and virus expressiol Endogenous Moloney leukemia virv hematopoietic cells (transplantation of hematopoietic stem cells/Mov-1 genome. expressioi (2016) (0)
Multiplex genome editing of human pluripotent stem cells using Cpf1 (2022) (0)
Abstract PR03: Delineating the roles of lysine 27 methylation-associated epigenetic modulators in T cell leukemia. (2015) (0)
Rapid iPSC inclusionopathy models shed light on formation, consequence and molecular subtype of α-synuclein inclusions (2022) (0)
A nuclear receptor facilitates differentiation of human PSCs into more mature hepatocytes (2022) (0)
VARIABLES ASSOCIATED WITH DERMATOSIS IN BROILERS Fátima (2012) (0)
Genetic Manipulation of the Mammalian Genome (1998) (0)
MeCP2 links heterochromatin condensates and neurodevelopmental disease (2020) (0)
Hominoid-Specific Transp osable Elements and KZFPs Facilitate Human Embryonic Genome Activation and Control Transcription in Naive Human ESCs Graphical (2019) (0)
Cell Stem Cell Review epigenetic differences in cellular (0)
The Role of K-ras Signaling in Erythropoiesis In Vivo. (2005) (0)
Cell Stem Cell Review Induced Pluripotent Stem Cells Meet Genome Editing (0)
Recessive and dominant mutations in transgenic mice. (1990) (0)
Stem cells, pluripotency and nuclear reprogramming (2013) (0)
Moloney murine leukemia virus encodes a non h 2 histocompatibility antigen in viremic mov strains (1988) (0)
Role of CD8+ αβ T Cells in Respiratory Infections Caused by Sendai Virus and Influenza Virus (1993) (0)
Prerearranged T Cell Receptor Genes Development in Mice with Endogenous Early TCR Expression and Aberrant T Cell (2007) (0)
The 16p11.2-Linked Gene, FAM57B Encodes a Modulator of Ceramide Synthesis that Regulates Lipid Levels and Synaptic Composition in the Developing Brain (2021) (0)
Aquatic Model Organisms in Neurosciences: The Genome-Editing Revolution -- Genome Editing in Neurosciences (2017) (0)
CD8[superscript +] T Cells from Mice Transnuclear for a TCR that Recognizes a Single H-2K[superscript b]-Restricted MHV68 Epitope Derived from gB-ORF8 Help Control Infection (2012) (0)
Whsc1 links pluripotency exit with mesendoderm specification (2019) (0)
Making the paper (2006) (0)
Methylphenidate modifies the motion of the circadian clock Lamotrigine in mood disorders and cocaine dependence Cortical glutamate in postpartum depression Tet 1 in Nucleus Accumbens Opposes Depression-and Anxiety-Like Behaviors (2017) (0)
973. Single-cell RNA Sequencing Analysis of Zika Virus Infection in Human Stem Cell-Derived Cerebral Organoids (2019) (0)
This information is current as Expansion 1 Is Critical for Effector CD 8 T Cell DNA Methylation by DNA Methyltransferase Jaenisch and Joshy (2006) (0)
Transcription of nicotinic acetylcholine receptor A7 in monocytic and patient‐derived microglial cell lines (2020) (0)
Collagen protein abnormalities produced by site-directed mutagenesis of the pro alpha 1(I) gene. (1989) (0)
[Genetic inheritance of tumor viruses]. (1980) (0)
Therapeutic Gene Editing in Muscles and Muscle Stem Cells -- Genome Editing in Neurosciences (2017) (0)
Response to “Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation” (2021) (0)
NEWSLETTER of the (2006) (0)
The Replication of Simian Virus 40 DNA (1974) (0)
into a safe harbor locus in the human genome isogenic settings using zinc finger nuclease-driven transgenesis Functional genomics , proteomics , and regulatory DNA analysis in Material Supplemental (2010) (0)
Maintenance of IAP Silencing Postimplantation Embryogenesis and the Dnmt 1 Expression in Pre-and (2004) (0)
Retroviruses as Insertional Mutagens (1987) (0)
Stem Cell Repor ts Q&A Interspecies Chimeras: An Interview with Rudolf Jaenisch (2018) (0)
Rejection of reliC Disparate Grafts by Wild-Type and ~ 2m Mutant Mice (2003) (0)
Autophagy is Required for the Maintenance of NAD (2022) (0)
Nuclear cloning, stem cells and epigenetic reprogramming (2007) (0)
The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes. (2022) (0)
Replication-competent Moloney mu bacterial suppressor tRNA gene: S and flanking host sequences (2016) (0)
Feodor-Lynen-Lecture: Stem cells, pluripotency and nuclear reprogramming (2008) (0)
Imprinted genes are epigenetically silenced on one of the two parental chromosomes in diploid embryonic cells. More than 30 protein-coding genes, plus a growing number of non-coding RNAs, have now been shown to be imprinted in both mice (2001) (0)
INVITED SPEAKERS; STEM CELLS, REPROGRAMMING AND PERSONALIZED MEDICINE: PROMISE, PROBLEMS, REALITY (2010) (0)
Correction for Reprogramming of murine and human somatic cells using a single polycistronic vector, by Bryce W. Carey (2009) (0)
APCs of Transgenic TLR9-GFP Mice Cell-Specific TLR9 Trafficking in Primary (2012) (0)
INVITED SPEAKERS; STEM CELLS AND THE MOLECULAR CONTROL OF PLURIPOTENCY (2010) (0)

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