Rudolph E. Tanzi | Academic Influence

Rudolph E. Tanzi's AcademicInfluence.com Rankings

Rudolph E. Tanzi

Medical

#470

World Rank

#643

Historical Rank

#189

USA Rank

Neurology

#32

World Rank

#64

Historical Rank

#15

USA Rank

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Medical

Rudolph E. Tanzi's Degrees

Masters Neurology Harvard University

Why Is Rudolph E. Tanzi Influential?

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According to Wikipedia, Rudolph Emile 'Rudy' Tanzi a professor of Neurology at Harvard University, vice-chair of neurology, director of the Genetics and Aging Research Unit, and co-director of the Henry and Allison McCance Center for Brain Health at Massachusetts General Hospital .

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Rudolph E. Tanzi's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis (1993) (6694)
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease (1995) (4114)
Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease (1996) (2328)
A polymorphic DNA marker genetically linked to Huntington's disease (1983) (2260)
Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database (2007) (1775)
Twenty Years of the Alzheimer’s Disease Amyloid Hypothesis: A Genetic Perspective (2005) (1770)
Common variants in MS4A4/MS4A6E, CD2uAP, CD33, and EPHA1 are associated with late-onset Alzheimer’s disease (2011) (1656)
Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus. (1987) (1493)
Rapid induction of Alzheimer A beta amyloid formation by zinc. (1994) (1389)
Mapping autism risk loci using genetic linkage and chromosomal rearrangements (2007) (1382)
Treatment with a Copper-Zinc Chelator Markedly and Rapidly Inhibits β-Amyloid Accumulation in Alzheimer's Disease Transgenic Mice (2001) (1349)
Association between microdeletion and microduplication at 16p11.2 and autism. (2008) (1338)
The Wilson disease gene is a copper transporting ATPase with homology to the Menkes disease gene (1993) (1270)
Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo (2003) (1226)
The genetic defect causing familial Alzheimer's disease maps on chromosome 21. (1987) (1180)
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing (2019) (1073)
Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database (2008) (1064)
The A beta peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction. (1999) (1048)
The genetics of Alzheimer disease. (2012) (984)
Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease (1988) (956)
Dramatic Aggregation of Alzheimer Aβ by Cu(II) Is Induced by Conditions Representing Physiological Acidosis* (1998) (947)
Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial. (2003) (922)
Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. (1996) (884)
A three-dimensional human neural cell culture model of Alzheimer’s disease (2014) (870)
Chronic Traumatic Encephalopathy in Blast-Exposed Military Veterans and a Blast Neurotrauma Mouse Model (2012) (817)
Alzheimer's disease: the cholesterol connection (2003) (814)
The Genetics of Alzheimer Disease: Back to the Future (2010) (805)
Increased hippocampal activation in mild cognitive impairment compared to normal aging and AD (2005) (765)
The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide (2010) (752)
Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta (2013) (742)
Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses (2008) (739)
Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo. (2003) (719)
Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction. (1999) (708)
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease (2017) (693)
Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease (2016) (678)
Alpha-2 macroglobulin is genetically associated with Alzheimer disease (1998) (665)
Use of structural magnetic resonance imaging to predict who will get Alzheimer's disease (2000) (661)
Rapid Restoration of Cognition in Alzheimer's Transgenic Mice with 8-Hydroxy Quinoline Analogs Is Associated with Decreased Interstitial Aβ (2008) (614)
Iron-Export Ferroxidase Activity of β-Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer's Disease (2010) (585)
Alzheimer–associated presenilins 1 and 2 : Neuronal expression in brain and localization to intracellular membranes in mammalian cells (1996) (580)
The genetic epidemiology of neurodegenerative disease. (2005) (561)
Characterization of copper interactions with alzheimer amyloid beta peptides: identification of an attomolar-affinity copper binding site on amyloid beta1-42. (2008) (548)
Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2). (2002) (546)
Comprehensive Research Synopsis and Systematic Meta-Analyses in Parkinson's Disease Genetics: The PDGene Database (2012) (546)
MRI measures of entorhinal cortex vs hippocampus in preclinical AD (2002) (536)
Evidence for genetic linkage of Alzheimer's disease to chromosome 10q. (2000) (521)
Preclinical prediction of AD using neuropsychological tests (2001) (519)
Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis. (2001) (500)
LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted β-amyloid precursor protein and mediates its degradation (1995) (499)
An Iron-responsive Element Type II in the 5′-Untranslated Region of the Alzheimer's Amyloid Precursor Protein Transcript* (2002) (499)
ApoE-4 and Age at Onset of Alzheimer's Disease (1997) (494)
Therapeutics for Alzheimer’s disease based on the metal hypothesis (2008) (491)
Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14 (1992) (472)
Mapping, cloning and genetic characterization of the region containing the Wilson disease gene (1993) (464)
New Frontiers in Alzheimer's Disease Genetics (2001) (463)
Aqueous Dissolution of Alzheimer’s Disease Aβ Amyloid Deposits by Biometal Depletion* (1999) (459)
Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE. (2008) (455)
Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer’s mouse model (2018) (440)
Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid β-peptide (2001) (433)
Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursor. (1992) (428)
Alzheimer's disease: genetic studies and transgenic models. (1998) (425)
Clearance of Alzheimer's Aβ Peptide The Many Roads to Perdition (2004) (403)
Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer’s disease (2016) (400)
Alzheimer’s Disease-Associated β-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection (2018) (398)
Redox‐Active Metals, Oxidative Stress, and Alzheimer's Disease Pathology (2004) (393)
Uptake of HIV-1 Tat protein mediated by low-density lipoprotein receptor-related protein disrupts the neuronal metabolic balance of the receptor ligands (2000) (375)
Homozygotes for Huntington's disease (1987) (372)
Genetic linkage of von Recklinghausen neurofibromatosis to the nerve growth factor receptor gene (1987) (370)
Expression of a ubiquitous, cross-reactive homologue of the mouse beta-amyloid precursor protein (APP). (1994) (363)
Results of a high-resolution genome screen of 437 Alzheimer's disease families. (2003) (362)
Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease. (1997) (362)
The Alzheimer's Disease-Associated Amyloid \(\beta\)-Protein Is an Antimicrobial Peptide (2010) (358)
Functional Links Between Aβ Toxicity, Endocytic Trafficking, and Alzheimer’s Disease Risk Factors in Yeast (2011) (358)
PBT2 rapidly improves cognition in Alzheimer's Disease: additional phase II analyses. (2010) (333)
Depletion of GGA3 Stabilizes BACE and Enhances β-Secretase Activity (2007) (325)
Presenilin-Mediated Modulation of Capacitative Calcium Entry (2000) (317)
Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis (2012) (308)
Zinc-induced Alzheimer’s Aβ1–40 Aggregation Is Mediated by Conformational Factors* (1997) (307)
A 3D Human Tri-Culture System Modeling Neurodegeneration and Neuroinflammation in Alzheimer’s Disease (2018) (304)
Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid β protein precursor (1993) (301)
Modulation of A beta adhesiveness and secretase site cleavage by zinc. (1994) (300)
Cytosolic β-amyloid deposition and supranuclear cataracts in lenses from people with Alzheimer's disease (2003) (300)
The common inhalation anesthetic isoflurane induces caspase activation and increases amyloid β‐protein level in vivo (2008) (295)
The Common Inhalation Anesthetic Isoflurane Induces Apoptosis and Increases Amyloid &bgr; Protein Levels (2006) (287)
Genetics of aging. (2003) (282)
Common variants at MS 4 A 4 / MS 4 A 6 E , CD 2 AP , CD 33 and EPHA 1 are associated with late-onset Alzheimer ’ s disease (2011) (274)
The genetic defect in familial Alzheimer's disease is not tightly linked to the amyloid β-protein gene (1987) (264)
The antimicrobial protection hypothesis of Alzheimer's disease (2018) (257)
The common inhalational anesthetic sevoflurane induces apoptosis and increases beta-amyloid protein levels. (2009) (256)
Amyloid β protein gene: cDNA, mRNA distribution and genetic linkage near the Alzheimer locus (1988) (255)
Neuropsychological measures in normal individuals that predict subsequent cognitive decline. (2007) (252)
Amyloid protein precursor messenger RNAs: differential expression in Alzheimer's disease. (1988) (245)
Modulation of beta-amyloid precursor protein processing by the low density lipoprotein receptor-related protein (LRP). Evidence that LRP contributes to the pathogenesis of Alzheimer's disease. (2000) (245)
The Inhalation Anesthetic Isoflurane Induces a Vicious Cycle of Apoptosis and Amyloid β-Protein Accumulation (2007) (240)
Trace metal contamination initiates the apparent auto-aggregation, amyloidosis, and oligomerization of Alzheimer’s Aβ peptides (2004) (239)
Family-based association between Alzheimer's disease and variants in UBQLN1. (2005) (233)
REVIEWThe Gene Defects Responsible for Familial Alzheimer's Disease (1996) (233)
Anesthetics isoflurane and desflurane differently affect mitochondrial function, learning, and memory (2012) (227)
Clearance of Alzheimer's Abeta peptide: the many roads to perdition. (2004) (226)
Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein. (2004) (225)
Endoproteolytic Cleavage and Proteasomal Degradation of Presenilin 2 in Transfected Cells* (1997) (225)
Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity. (2007) (223)
Genome-wide association studies in Alzheimer's disease. (2009) (221)
Modulation of γ-Secretase Reduces β-Amyloid Deposition in a Transgenic Mouse Model of Alzheimer's Disease (2010) (217)
Characterization of the Precursor Protein of the Non-Aβ Component of Senile Plaques (NACP) in the Human Central Nervous System (1996) (217)
The inhalation anesthetic isoflurane increases levels of proinflammatory TNF-α, IL-6, and IL-1β (2012) (216)
Expression and analysis of presenilin 1 in a human neuronal system: localization in cell bodies and dendrites. (1996) (216)
Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity. (2009) (212)
Magnetic resonance imaging white matter hyperintensities and brain volume in the prediction of mild cognitive impairment and dementia. (2008) (211)
Selective induction of Kunitz-type protease inhibitor domain-containing amyloid precursor protein mRNA after persistent focal ischemia in rat cerebral cortex (1991) (209)
Alzheimer's disease: one disorder, too many genes? (2004) (209)
Tau molecular diversity contributes to clinical heterogeneity in Alzheimer’s disease (2020) (200)
Assessment of amyloid beta-protein precursor gene mutations in a large set of familial and sporadic Alzheimer disease cases. (1992) (200)
A 3D human neural cell culture system for modeling Alzheimer's disease (2015) (197)
Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study (2019) (194)
ADAM10 Missense Mutations Potentiate β-Amyloid Accumulation by Impairing Prodomain Chaperone Function (2013) (192)
Apolipoprotein E, survival in Alzheimer's disease patients, and the competing risks of death and Alzheimer's disease (1995) (188)
Metal Chelation as a Potential Therapy for Alzheimer's Disease (2000) (183)
The synaptic Aβ hypothesis of Alzheimer disease (2005) (182)
Presenilins and Alzheimer's disease (1997) (181)
3-Hydroxykynurenine and 3-hydroxyanthranilic acid generate hydrogen peroxide and promote alpha-crystallin cross-linking by metal ion reduction. (2000) (178)
BACE Is Degraded via the Lysosomal Pathway* (2005) (171)
Alzheimer's disease-associated TREM2 variants exhibit either decreased or increased ligand-dependent activation (2017) (169)
The genetics of Alzheimer disease: current status and future prospects. (1998) (167)
TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer’s Disease (2019) (163)
Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE/PS1ΔE9 murine model of Alzheimer’s disease (2017) (159)
Alzheimer's disease and post-operative cognitive dysfunction (2006) (159)
The Zinc Dyshomeostasis Hypothesis of Alzheimer's Disease (2012) (158)
Curcumin Decreases Amyloid-β Peptide Levels by Attenuating the Maturation of Amyloid-β Precursor Protein* (2010) (156)
Longitudinal change in cognitive performance among individuals with mild cognitive impairment. (2007) (155)
Comment on “ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models” (2013) (153)
The gene defects responsible for familial Alzheimer's disease. (1996) (150)
Genetic association of an (α2-macroglobulin (Val1000lle) polymorphism and Alzheimer's disease (1998) (150)
Near-infrared fluorescence molecular imaging of amyloid beta species and monitoring therapy in animal models of Alzheimer’s disease (2015) (149)
Cytosolic beta-amyloid deposition and supranuclear cataracts in lenses from people with Alzheimer's disease. (2003) (149)
Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein. (1996) (148)
A genetic dichotomy model for the inheritance of Alzheimer's disease and common age-related disorders. (1999) (145)
Diabetes-Associated SorCS1 Regulates Alzheimer's Amyloid-β Metabolism: Evidence for Involvement of SorL1 and the Retromer Complex (2010) (145)
Calcium Responses in Fibroblasts from Asymptomatic Members of Alzheimer's Disease Families (1998) (144)
The 5′-untranslated region of Parkinson's disease α-synuclein messengerRNA contains a predicted iron responsive element (2007) (144)
Kunitz Protease Inhibitor‐Containing Amyloid β Protein Precursor Immunoreactivity in Alzheimer's Disease (1992) (143)
Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study. (2014) (140)
Absence of duplication of chromosome 21 genes in familial and sporadic Alzheimer's disease. (1987) (139)
Trial of Sodium Phenylbutyrate-Taurursodiol for Amyotrophic Lateral Sclerosis. (2020) (139)
The current status of Alzheimer's disease genetics: what do we tell the patients? (2004) (138)
The amyloid beta protein gene is not duplicated in brains from patients with Alzheimer's disease. (1987) (138)
Molecular and prospective phenotypic characterization of a pedigree with familial Alzheimer's disease and a missense mutation in codon 717 of the β‐amyloid precursor protein gene (1992) (133)
Association of a haplotype for tumor necrosis factor in siblings with late-onset Alzheimer disease: the NIMH Alzheimer Disease Genetics Initiative. (2000) (132)
Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid beta protein precursor. (1993) (131)
Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimerʼs disease (1988) (130)
BACE Maps to Chromosome 11 and a BACE Homolog, BACE2, Reside in the Obligate Down Syndrome Region of Chromosome 21 (1999) (127)
Preliminary studies of a novel bifunctional metal chelator targeting Alzheimer's amyloidogenesis (2004) (127)
Isoflurane-induced apoptosis: a potential pathogenic link between delirium and dementia. (2006) (123)
Localization of the huntington's disease gene to a small segment of chromosome 4 flanked by D4S10 and the telomere (1987) (122)
Deletion of Huntington's disease-linked G8 (D4S10) locus in Wolf–Hirschhorn syndrome (1985) (121)
Differential effects of apolipoprotein E isoforms on metal-induced aggregation of A beta using physiological concentrations. (1999) (119)
Blood–Brain Barrier Dysfunction in a 3D In Vitro Model of Alzheimer's Disease (2019) (119)
Copper, β-amyloid, and Alzheimer's disease: Tapping a sensitive connection (2003) (118)
Metal exposure and Alzheimer's pathogenesis. (2006) (118)
Alzheimer's Disease Amyloid-β Links Lens and Brain Pathology in Down Syndrome (2010) (118)
DNA markers for nervous system diseases. (1984) (118)
The amyloid beta-protein precursor and its mammalian homologues. Evidence for a zinc-modulated heparin-binding superfamily. (1994) (118)
DNA sequence and regional assignment of the human follicle-stimulating hormone beta-subunit gene to the short arm of human chromosome 11. (1987) (116)
Protein Aggregates and Novel Presenilin Gene Variants in Idiopathic Dilated Cardiomyopathy (2010) (115)
Isoflurane-Induced Caspase-3 Activation Is Dependent on Cytosolic Calcium and Can Be Attenuated by Memantine (2008) (115)
Genetic linkage map of human chromosome 21. (1988) (113)
The genetics of Alzheimer's disease (2000) (112)
Presenilin 2 Interacts with Sorcin, a Modulator of the Ryanodine Receptor* (2000) (110)
Relative Increase in Alzheimer’s Disease of Soluble Forms of Cerebral Aβ Amyloid Protein Precursor Containing the Kunitz Protease Inhibitory Domain* (1998) (106)
Alzheimer's mutation (1991) (105)
Induction of HSP70 mRNA after transient ischemia in gerbil brain (1991) (104)
Alzheimer's disease, beta-amyloid protein and zinc. (2000) (103)
The Effects of Isoflurane and Desflurane on Cognitive Function in Humans (2012) (103)
The Inhalation Anesthetic Desflurane Induces Caspase Activation and Increases Amyloid β-Protein Levels under Hypoxic Conditions* (2008) (100)
The role of clusterin, complement receptor 1, and phosphatidylinositol binding clathrin assembly protein in Alzheimer disease risk and cerebrospinal fluid biomarker levels. (2011) (97)
Association of GSK3B with Alzheimer disease and frontotemporal dementia. (2008) (96)
3D culture models of Alzheimer’s disease: a road map to a “cure-in-a-dish” (2016) (92)
Mutant presenilin 2 transgenic mice. A large increase in the levels of Abeta 42 is presumably associated with the low density membrane domain that contains decreased levels of glycerophospholipids and sphingomyelin. (2000) (92)
Cu(II) Potentiation of Alzheimer Aβ Neurotoxicity (1999) (92)
Astrocytic interleukin-3 programs microglia and limits Alzheimer’s disease (2021) (92)
The synaptic Abeta hypothesis of Alzheimer disease. (2005) (90)
Autoantibodies to Redox-modified Oligomeric Aβ Are Attenuated in the Plasma of Alzheimer's Disease Patients* (2005) (90)
Copper catalyzed oxidation of Alzheimer Abeta. (2000) (89)
Ubiquilin 1 Modulates Amyloid Precursor Protein Trafficking and Aβ Secretion* (2006) (89)
Age-dependent postoperative cognitive impairment and Alzheimer-related neuropathology in mice (2014) (88)
Induction of amyloid precursor protein mRNA after heat shock in cultured human lymphoblastoid cells (1991) (87)
Cerebrospinal Fluid Levels of Amyloid Precursor Protein and Amyloid β-Peptide in Alzheimer’s Disease and Major Depression – Inverse Correlation with Dementia Severity (1998) (87)
CRISPR/Cas9-Correctable mutation-related molecular and physiological phenotypes in iPSC-derived Alzheimer’s PSEN2N141I neurons (2017) (86)
The galvanization of β-amyloid in Alzheimer's disease (2002) (86)
Decreased Catalytic Activity of the Insulin-degrading Enzyme in Chromosome 10-Linked Alzheimer Disease Families* (2007) (86)
Family-based Association Analyses of Imputed Genotypes Reveal Genome-Wide Significant Association of Alzheimer’s disease with OSBPL6, PTPRG and PDCL3 (2015) (84)
Effect of potent γ-secretase modulator in human neurons derived from multiple presenilin 1-induced pluripotent stem cell mutant carriers. (2014) (84)
hFE65L Influences Amyloid Precursor Protein Maturation and Secretion (1999) (83)
Isolation of polymorphic DNA segments from human chromosome 21. (1985) (83)
Rare autosomal copy number variations in early-onset familial Alzheimer’s disease (2014) (82)
Human Neurospheroid Arrays for In Vitro Studies of Alzheimer’s Disease (2018) (81)
Genetic association of Alzheimer's disease with multiple polymorphisms in alpha-2-macroglobulin. (2003) (79)
Developmental Regulation of Presenilin mRNA Expression Parallels Notch Expression (1997) (79)
Chelation and intercalation: complementary properties in a compound for the treatment of Alzheimer's disease. (2000) (77)
Clearance of Alzheimer's Aβ PeptideThe Many Roads to Perdition (2004) (77)
A novel presenilin‐1 mutation: Increased β‐amyloid and neurofibrillary changes (1997) (77)
Screening for mutations in the open reading frame and promoter of the beta-amyloid precursor protein gene in familial Alzheimer's disease: identification of a further family with APP717 Val-->Ile. (1992) (77)
Alzheimer's in 3D culture: Challenges and perspectives (2015) (75)
Developing Effective Alzheimer’s Disease Therapies: Clinical Experience and Future Directions (2019) (74)
Cerebrospinal Fluid A&bgr; to Tau Ratio and Postoperative Cognitive Change (2013) (74)
Sex Differences in Cognitive Decline in Subjects with High Likelihood of Mild Cognitive Impairment due to Alzheimer’s disease (2018) (74)
Alzheimer's Disease‐Associated Ubiquilin‐1 Regulates Presenilin‐1 Accumulation and Aggresome Formation (2011) (72)
Mapping of the gene encoding the beta-amyloid precursor protein and its relationship to the Down syndrome region of chromosome 21. (1988) (72)
Alzheimer's Disease Amyloid-\(\beta\) Links Lens and Brain Pathology in Down Syndrome (2010) (71)
A brief history of Alzheimer's disease gene discovery. (2012) (71)
Assessment of Alzheimer’s disease case–control associations using family-based methods (2009) (71)
Selective localization of amyloid precursor-like protein 1 in the cerebral cortex postsynaptic density. (1995) (71)
Comparative mapping of DNA markers from the familial Alzheimer disease and Down syndrome regions of human chromosome 21 to mouse chromosomes 16 and 17. (1988) (71)
Generation of the β-Amyloid Peptide and the Amyloid Precursor Protein C-terminal Fragment γ Are Potentiated by FE65L1* (2003) (70)
Gain-of-function mutations in protein kinase Cα (PKCα) may promote synaptic defects in Alzheimer’s disease (2016) (70)
Progress toward valid transgenic mouse models for Alzheimer’s disease (1999) (70)
Evidence of Altered Posteromedial Cortical fMRI Activity in Subjects at Risk for Alzheimer Disease (2010) (70)
A genetic linkage map of human chromosome 21: analysis of recombination as a function of sex and age. (1992) (70)
Familial Alzheimer's disease: Progress and problems (1989) (70)
Molecular genetic approaches to Alzheimer's disease (1989) (69)
Meditation and vacation effects have an impact on disease-associated molecular phenotypes (2016) (67)
Dancing in the dark? (2001) (66)
HtrA2 Regulates β-Amyloid Precursor Protein (APP) Metabolism through Endoplasmic Reticulum-associated Degradation* (2007) (66)
Amyloid-β42/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer’s disease (2020) (65)
Isoflurane Decreases Self-renewal Capacity of Rat Cultured Neural Stem Cells (2011) (64)
Age-Dependent Effect of Apolipoprotein E4 on Functional Outcome after Controlled Cortical Impact in Mice (2011) (63)
Anesthetic Propofol Attenuates the Isoflurane-Induced Caspase-3 Activation and Aβ Oligomerization (2011) (63)
Abrogation of the Presenilin 1/β-Catenin Interaction and Preservation of the Heterodimeric Presenilin 1 Complex following Caspase Activation* (1998) (63)
Phosphorylation of Alzheimer beta-amyloid precursor-like proteins. (1997) (62)
Candidate genes showing no evidence for association or linkage with Alzheimer's disease using family-based methodologies (2000) (62)
Amyloid-b peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease (2016) (62)
The amyloid precursor-like protein (APLP) gene maps to the long arm of human chromosome 19. (1993) (60)
Identification of clusters of rapid and slow decliners among subjects at risk for Alzheimer’s disease (2017) (60)
RNA Interference Silencing of the Adaptor Molecules ShcC and Fe65 Differentially Affect Amyloid Precursor Protein Processing and Aβ Generation* (2007) (60)
Identification of NEEP21 as a β-Amyloid Precursor Protein-Interacting Protein In Vivo That Modulates Amyloidogenic Processing In Vitro (2010) (60)
Characterization of Copper Interactions with Alzheimer Amyloid β Peptides (2000) (60)
Spatial Memory Is Intact in Aged Rats After Propofol Anesthesia (2008) (59)
Author Correction: Exercise hormone irisin is a critical regulator of cognitive function (2021) (59)
Association of membrane-bound amyloid precursor protein APP with the apolipoprotein E receptor LRP. (2001) (59)
The Human Variome Project (2008) (59)
Cromolyn Reduces Levels of the Alzheimer’s Disease-Associated Amyloid β-Protein by Promoting Microglial Phagocytosis (2018) (58)
Staurosporine‐Induced Activation of Caspase‐3 Is Potentiated by Presenilin 1 Familial Alzheimer's Disease Mutations in Human Neuroglioma Cells (1999) (58)
Long‐term survival of participants in the CENTAUR trial of sodium phenylbutyrate‐taurursodiol in amyotrophic lateral sclerosis (2020) (58)
PLD3 gene variants and Alzheimer's disease (2015) (57)
Alzheimer’s disease drug discovery targeted to the APP mRNA 5′Untranslated region (2002) (56)
Peripheral Surgical Wounding and Age-Dependent Neuroinflammation in Mice (2014) (56)
The CALHM1 P86L polymorphism is a genetic modifier of age at onset in Alzheimer's disease: a meta-analysis study. (2010) (55)
Loss of Function of ATXN1 Increases Amyloid β-Protein Levels by Potentiating β-Secretase Processing of β-Amyloid Precursor Protein* (2010) (55)
No Association between CALHM1 and Alzheimer's Disease Risk (2008) (55)
Altered hippocampal gene expression 2 days after general anesthesia in rats. (2006) (55)
Molecular Mechanisms of Dementia (2013) (55)
Molecular genetics of Alzheimer disease amyloid. (1991) (55)
Alzheimer disease risk genes: 29 and counting (2019) (54)
A randomized, exploratory molecular imaging study targeting amyloid β with a novel 8-OH quinoline in Alzheimer's disease: The PBT2-204 IMAGINE study (2017) (54)
Caspase Activation Increases β-Amyloid Generation Independently of Caspase Cleavage of the β-Amyloid Precursor Protein (APP)* (2003) (54)
Alzheimer’s Disease-Associated β-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection (2018) (54)
Amyloid, dementia and Alzheimer's disease. (1992) (53)
Metal-Protein Attenuation With Iodochlorhydroxyquin (Clioquinol) Targeting A Amyloid Deposition and Toxicity in Alzheimer Disease (2003) (53)
The role of innate immune genes in Alzheimer's disease (2021) (53)
Neuronal Intranuclear Inclusions in Polyglutamine Diseases Nuclear Weapons or Nuclear Fallout? (1998) (53)
Genome-wide linkage analysis of 723 affected relative pairs with late-onset Alzheimer's disease. (2007) (53)
Meditation and Yoga Practices as Potential Adjunctive Treatment of SARS-CoV-2 Infection and COVID-19: A Brief Overview of Key Subjects. (2020) (52)
SUMO1 modulates Aβ generation via BACE1 accumulation (2013) (51)
Lack of hepatic apoE does not influence early Aβ deposition: observations from a new APOE knock-in model (2019) (51)
Optical Coherence Tomography for Brain Imaging and Developmental Biology (2016) (51)
An AICD-based functional screen to identify APP metabolism regulators (2007) (50)
GAB2 as an Alzheimer disease susceptibility gene: follow-up of genomewide association results. (2009) (49)
Blood Biomarkers for Detection of Brain Injury in COVID-19 Patients (2020) (49)
Huntington disease: no evidence for locus heterogeneity. (1989) (49)
Isolation and characterization of the Drosophila ubiquilin ortholog dUbqln: in vivo interaction with early-onset Alzheimer disease genes. (2007) (48)
GSK3β Forms a Tetrameric Complex with Endogenous PS1‐CTF/NTF and β‐Catenin: Effects of the D257/D385A and FAD‐linked Mutations (2000) (48)
Modulation of β-Amyloid Precursor Protein Processing by the Low Density Lipoprotein Receptor-related Protein (LRP) (2000) (47)
Metalloenzyme-like Activity of Alzheimer's Disease β-Amyloid (2002) (47)
In situ hybridization analysis of presenilin 1 mRNA in Alzheimer disease and in lesioned rat brain. (1996) (46)
RNA Interference-mediated Silencing of X11α and X11β Attenuates Amyloid β-Protein Levels via Differential Effects on β-Amyloid Precursor Protein Processing* (2005) (46)
Optogenetic pacing in Drosophila melanogaster (2015) (46)
Insulin-degrading enzyme is genetically associated with Alzheimer’s disease in the Finnish population (2007) (45)
TREM2 and Risk of Alzheimer's Disease--Friend or Foe? (2015) (45)
Is Alzheimer's Disease a Neurogenesis Disorder? (2019) (44)
Immunohistochemical and in situ analysis of amyloid precursor-like protein-1 and amyloid precursor-like protein-2 expression in Alzheimer disease and aged control brains (1998) (43)
Evaluation of the potential excess of statistically significant findings in published genetic association studies: application to Alzheimer's disease. (2008) (43)
A novel lysosome‐to‐mitochondria signaling pathway disrupted by amyloid‐β oligomers (2018) (43)
A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer’s disease (2018) (42)
Alzheimer disease: New light on an old CLU (2010) (42)
Genetic association of an alpha2-macroglobulin (Val1000lle) polymorphism and Alzheimer's disease. (1998) (42)
Peroxidase Activity of Cyclooxygenase-2 (COX-2) Cross-links β-Amyloid (Aβ) and Generates Aβ-COX-2 Hetero-oligomers That Are Increased in Alzheimer's Disease* (2004) (42)
Generation of the beta-amyloid peptide and the amyloid precursor protein C-terminal fragment gamma are potentiated by FE65L1. (2003) (41)
Emerging role of Alzheimer's disease-associated ubiquilin-1 in protein aggregation. (2010) (41)
The Pathway Coexpression Network: Revealing pathway relationships (2018) (41)
Copper, beta-amyloid, and Alzheimer's disease: tapping a sensitive connection. (2003) (41)
LRP-mediated clearance of Abeta is inhibited by KPI-containing isoforms of APP. (2005) (40)
Soluble γ-Secretase Modulators Selectively Inhibit the Production of the 42-Amino Acid Amyloid β Peptide Variant and Augment the Production of Multiple Carboxy-Truncated Amyloid β Species (2014) (40)
Cathepsin L Mediates the Degradation of Novel APP C-Terminal Fragments. (2015) (39)
Cellular specificity and regional distribution of amyloid beta protein precursor alternative transcripts are unaltered in Alzheimer hippocampal formation. (1993) (39)
Age-Dependent, Non-Cell-Autonomous Deposition of Amyloid from Synthesis of β-Amyloid by Cells Other Than Excitatory Neurons (2014) (39)
Rarity of the Alzheimer disease-protective APP A673T variant in the United States. (2015) (39)
The rare TREM2 R47H variant exerts only a modest effect on Alzheimer disease risk (2014) (38)
Loss of Ataxin-1 Potentiates Alzheimer’s Pathogenesis by Elevating Cerebral BACE1 Transcription (2019) (38)
A novel protein, amyloid precursor-like protein 2, is present in human brain, cerebrospinal fluid and conditioned media. (1995) (37)
Trisomy 21 (Down syndrome): studying nondisjunction and meiotic recombination by using cytogenetic and molecular polymorphisms that span chromosome 21. (1988) (36)
Recovering unused information in genome-wide association studies: the benefit of analyzing SNPs out of Hardy–Weinberg equilibrium (2009) (36)
The upstream stimulatory factor functionally interacts with the Alzheimer amyloid beta-protein precursor gene. (1995) (36)
Microglial dysfunction as a key pathological change in adrenomyeloneuropathy (2017) (36)
Alzheimer disease-related abnormalities of amyloid beta precursor protein isoforms in the platelet: the brain's delegate in the periphery? (1998) (36)
Inhibitors of β-Amyloid Formation Based on the β-Secretase Cleavage Site (2000) (35)
Alzheimer's disease: The latest suspect (2008) (35)
Synaptotagmins interact with APP and promote Aβ generation (2015) (35)
Pharmacological and Toxicological Properties of the Potent Oral γ-Secretase Modulator BPN-15606 (2017) (35)
The Amazon rain forest plant Uncaria tomentosa (cat’s claw) and its specific proanthocyanidin constituents are potent inhibitors and reducers of both brain plaques and tangles (2019) (35)
APP substitutions V715F and L720P alter PS1 conformation and differentially affect Aβ and AICD generation (2005) (34)
Gene therapy for Alzheimer's Disease targeting CD33 reduces amyloid beta accumulation and neuroinflammation. (2020) (34)
Anti-apoptotic action of Alzheimer Ab (1999) (34)
Irradiation-reduced human chromosome 21 hybrids (1988) (34)
Hypocapnia Induces Caspase-3 Activation and Increases Aβ Production (2004) (33)
Of replications and refutations: The status of Alzheimer’s disease genetic research (2001) (33)
Identification of Altered Metabolomic Profiles Following a Panchakarma-based Ayurvedic Intervention in Healthy Subjects: The Self-Directed Biological Transformation Initiative (SBTI) (2016) (33)
Cysteine 27 Variant of the δ-Opioid Receptor Affects Amyloid Precursor Protein Processing through Altered Endocytic Trafficking (2011) (33)
Zinc and Alzheimers-Disease - Response (1995) (33)
Negative Regulation of the Sapk/Jnk Signaling Pathway by Presenilin 1 (2001) (33)
GSK3 beta forms a tetrameric complex with endogenous PS1-CTF/NTF and beta-catenin. Effects of the D257/D385A and FAD-linked mutations. (2000) (32)
No evidence for genetic association or linkage of the cathepsin D (CTSD) exon 2 polymorphism and Alzheimer disease (2001) (32)
Inhibition of death-associated protein kinase 1 attenuates the phosphorylation and amyloidogenic processing of amyloid precursor protein. (2016) (32)
Alzheimer's disease: the potential therapeutic role of the natural antibiotic amyloid-β peptide. (2016) (32)
Changes in the expression of the Alzheimer’s disease-associated presenilin gene in drosophila heart leads to cardiac dysfunction. (2011) (31)
Wilson's disease gene is homologous to hts causing abnormal copper transport in Long-Evans cinnamon rats. (1994) (31)
iPSC-derived familial Alzheimer’s PSEN2N141I cholinergic neurons exhibit mutation-dependent molecular pathology corrected by insulin signaling (2018) (31)
The role of the low-density lipoprotein receptor-related protein (LRP1) in alzheimer’s Aβ generation (2002) (31)
A γ-Secretase Inhibitor, but Not a γ-Secretase Modulator, Induced Defects in BDNF Axonal Trafficking and Signaling: Evidence for a Role for APP (2015) (30)
Effects of RNAi-mediated silencing of PEN-2, APH-1a, and nicastrin on wild-type vs FAD mutant forms of presenilin 1 (2007) (29)
Relationship between ubiquilin-1 and BACE1 in human Alzheimer's disease and APdE9 transgenic mouse brain and cell-based models (2016) (29)
The ETS genes on chromosome 21 are distal to the breakpoint of the acute myelogenous leukemia translocation (8;21). (1988) (29)
Silencing of the Drosophila ortholog of SOX5 in heart leads to cardiac dysfunction as detected by optical coherence tomography. (2013) (29)
A novel presenilin-1 mutation: increased beta-amyloid and neurofibrillary changes. (1997) (28)
Genome-wide association study of Alzheimer’s disease CSF biomarkers in the EMIF-AD Multimodal Biomarker Discovery dataset (2019) (28)
The anesthetic sevoflurane induces tau trafficking from neurons to microglia (2021) (28)
How Consciousness Becomes the Physical Universe (28)
Effects of Ubiquilin 1 on the Unfolded Protein Response (2009) (28)
Preclinical validation of a potent γ-secretase modulator for Alzheimer’s disease prevention (2021) (27)
Significant Upregulation of Alzheimer's β‐Amyloid Levels in a Living System Induced by Extracellular Elastin Polypeptides (2019) (27)
Molecular and cytogenetic characterization of a de novo t(5p;21q) in a patient previously diagnosed as monosomy 21. (1988) (27)
Caspase activation increases beta-amyloid generation independently of caspase cleavage of the beta-amyloid precursor protein (APP). (2003) (27)
Low‐density lipoprotein receptor‐related protein levels and endocytic function are reduced by overexpression of the FE65 adaptor protein, FE65L1 (2002) (27)
Monogenic determinants of familial Alzheimer's disease: presenilin-1 mutations (1998) (27)
Multi-omic comparison of Alzheimer’s variants in human ESC–derived microglia reveals convergence at APOE (2020) (26)
Neuropathology in the Down's syndrome brain (1996) (26)
A Circadian Clock Gene, Cry, Affects Heart Morphogenesis and Function in Drosophila as Revealed by Optical Coherence Microscopy (2015) (26)
Family-Based Association between Alzheimer ’ s Disease and Variants in UBQLN 1 (2005) (26)
Nonisotopic in situ hybridization of amyloid beta protein precursor in Alzheimer's disease: expression in neurofibrillary tangle bearing neurons and in the microenvironment surrounding senile plaques. (1993) (26)
Silencing of the Drosophila ortholog of SOX5 leads to abnormal neuronal development and behavioral impairment (2017) (26)
Author Correction: Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing (2019) (26)
Neuroinflammatory Responses in the Alzheimer's Disease Brain Promote the Oxidative Post‐translational Modification of Amyloid Deposits (2002) (26)
Stratifying risk for dementia onset using large-scale electronic health record data: a retrospective cohort study (2019) (25)
Alzheimer's Disease : Advances in Genetics, Molecular and Cellular Biology (2007) (25)
Cromolyn sodium delays disease onset and is neuroprotective in the SOD1G93A Mouse Model of amyotrophic lateral sclerosis (2019) (25)
Effects of RNA Interference-mediated Silencing of γ-Secretase Complex Components on Cell Sensitivity to Caspase-3 Activation* (2004) (25)
Identification of Novel Alzheimer’s Disease Loci Using Sex-Specific Family-Based Association Analysis of Whole-Genome Sequence Data (2020) (25)
Cytokine-mediated inflammation mediates painful neuropathy from metabolic syndrome (2018) (25)
RNA interference-mediated silencing of X11alpha and X11beta attenuates amyloid beta-protein levels via differential effects on beta-amyloid precursor protein processing. (2005) (25)
Genomic mechanisms in Alzheimer's disease (2020) (24)
iPSCs to the rescue in Alzheimer's research. (2012) (24)
Molecular epidemiology of Alzheimer's disease. (1995) (24)
Linkage analysis in a family with dominantly inherited torsion dystonia: exclusion of the pro-opiomelanocortin and glutamic acid decarboxylase genes and other chromosomal regions using DNA polymorphisms. (1986) (23)
Interaction between Presenilin 1 and Ubiquilin 1 as Detected by Fluorescence Lifetime Imaging Microscopy and a High-throughput Fluorescent Plate Reader* (2006) (23)
Correction: The Zinc Dyshomeostasis Hypothesis of Alzheimer's Disease (2012) (23)
Whole‐genome sequencing reveals new Alzheimer's disease–associated rare variants in loci related to synaptic function and neuronal development (2021) (23)
Tangles and neurodegenerative disease--a surprising twist. (2005) (23)
Relevance of the COPI complex for Alzheimer’s disease progression in vivo (2016) (23)
Molecular genetics of human chromosome 21. (1986) (22)
Molecular genetics of Alzheimer's disease and the amyloid beta peptide precursor gene. (1989) (22)
Analysis of hidradenitis suppurativa‐linked mutations in four genes and the effects of PSEN1‐P242LfsX11 on cytokine and chemokine expression in macrophages (2018) (22)
Elucidation of the BACE1 regulating factor GGA3 in Alzheimer's disease. (2013) (22)
Plasma IL‐12/IFN‐γ axis predicts cognitive trajectories in cognitively unimpaired older adults (2021) (21)
Potential use of γ-secretase modulators in the treatment of Alzheimer disease. (2012) (21)
Exploring candidate gene associations with neuropsychological performance (2007) (21)
Soluble Gamma-secretase Modulators Attenuate Alzheimer's β-amyloid Pathology and Induce Conformational Changes in Presenilin 1 (2017) (21)
Relationships among classifications of ayurvedic medicine diagnostics for imbalances and western measures of psychological states: An exploratory study (2018) (21)
Analysis of the c‐FOS gene on chromosome 14 and the promoter of the amyloid precursor protein gene in familial Alzheimer's disease (1993) (20)
Familial Alzheimer's disease mutations in presenilin 1 do not alter levels of the secreted amyloid-beta protein precursor generated by beta-secretase cleavage. (2009) (20)
Association of UBQLN1 mutation with Brown–Vialetto–Van Laere syndrome but not typical ALS (2012) (20)
Amyloid-β production via cleavage of amyloid-β protein precursor is modulated by cell density. (2010) (20)
Dissecting Alzheimer's disease pathogenesis in human 2D and 3D models (2020) (19)
Isolation, characterization, and mapping of gene encoding dihydrolipoyl succinyltransferase (E2k) of humanα-ketoglutarate dehydrogenase complex (1994) (19)
Axonal generation of amyloid-β from palmitoylated APP in mitochondria-associated endoplasmic reticulum membranes (2021) (19)
ANTI-APOPTOTIC ACTION OF ALZHEIMER BETA AMYLOID (1999) (19)
The role of the low-density lipoprotein receptor-related protein (LRP1) in Alzheimer's A beta generation: development of a cell-based model system. (2002) (19)
BACE1 Regulates Proliferation and Neuronal Differentiation of Newborn Cells in the Adult Hippocampus in Mice (2018) (19)
Potential therapeutic targets for Alzheimer’s disease (1998) (18)
PEN2 is not a genetic risk factor for Alzheimer’s disease in a large family sample (2004) (18)
The LDLR locus in alzheimer's disease: A family-based study and meta-analysis of case-control data (2007) (18)
Palmitoylated APP Forms Dimers, Cleaved by BACE1 (2016) (18)
Gut microbiota–driven brain Aβ amyloidosis in mice requires microglia (2021) (18)
Molecular genetics of Huntington's disease. (1986) (17)
Is α-T catenin (VR22) an Alzheimer’s disease risk gene? (2006) (17)
Peroxidase activity of cyclooxygenase-2 (COX-2) cross-links beta-amyloid (Abeta) and generates Abeta-COX-2 hetero-oligomers that are increased in Alzheimer's disease. (2004) (16)
Evidence against association of the FE65 gene (APBB1) intron 13 polymorphism in Alzheimer's patients (2000) (16)
FDA Approval of Aduhelm Paves a New Path for Alzheimer's Disease. (2021) (16)
Caspases land on APP: One small step for apoptosis, one giant leap for amyloidosis? (1999) (16)
Recapitulating amyloid β and tau pathology in human neural cell culture models: clinical implications. (2015) (16)
A Multidisciplinary Approach to Mind and Consciousness (2013) (15)
Low Evolutionary Selection Pressure in Senescence Does Not Explain the Persistence of Aβ in the Vertebrate Genome (2019) (15)
Chronic traumatic encephalopathy (CTE) in blast-exposed U.S. military veterans and a new blast neurotrauma mouse model (2012) (15)
Effect of sodium phenylbutyrate/taurursodiol on tracheostomy/ventilation-free survival and hospitalisation in amyotrophic lateral sclerosis: long-term results from the CENTAUR trial (2022) (15)
Whole-genome sequencing reveals new Alzheimer's disease-associated rare variants in loci related to synaptic function and neuronal development (2020) (15)
Inhibitors of beta-amyloid formation based on the beta-secretase cleavage site. (2000) (15)
Genetic heterogeneity of gene defects responsible for familial Alzheimer disease (2005) (15)
A Curcumin Analog Reduces Levels of the Alzheimer's Disease-Associated Amyloid-β Protein by Modulating AβPP Processing and Autophagy. (2019) (15)
Hypoxic ischemia and proteasome dysfunction alter tau isoform ratio by inhibiting exon 10 splicing (2010) (14)
Targeting ubiquilin-1 in Alzheimer's disease (2013) (14)
Extracellular Elastin Molecule Modulates Alzheimer’s Aβ Dynamics In Vitro and In Vivo by Affecting Microglial Activities (2020) (14)
A current view of Alzheimer's disease (2009) (14)
Design and synthesis of aminothiazole modulators of the gamma-secretase enzyme. (2016) (14)
Brown adipose tissue-derived MaR2 contributes to cold-induced resolution of inflammation (2022) (14)
TREM2 and neurodegenerative disease. (2013) (14)
Further evidence for LBP-1c/CP2/LSF association in Alzheimer’s disease families (2005) (14)
Aβ-accelerated neurodegeneration caused by Alzheimer’s-associated ACE variant R1279Q is rescued by angiotensin system inhibition in mice (2020) (14)
RNAi-mediated knock-down of Dab and Numb attenuate Aβ levels via γ-secretase mediated APP processing (2012) (14)
CALHM1 P86L polymorphism does not alter amyloid-β or tau in cerebrospinal fluid (2010) (14)
Association of GSK 3 B With Alzheimer Disease and Frontotemporal Dementia (2008) (14)
Gene mutations in inherited amyloidopathies of the nervous system. (1991) (13)
Upregulation of Alzheimer's Disease Amyloid-β Protein Precursor in Astrocytes Both in vitro and in vivo. (2020) (13)
Welcome to the complex disease world Alpha2-macroglobulin and Alzheimer's disease (2003) (13)
Is alpha-T catenin (VR22) an Alzheimer's disease risk gene? (2007) (13)
Single-nucleotide polymorphism rs498055 on chromosome 10q24 is not associated with Alzheimer disease in two independent family samples. (2006) (13)
A novel but non-pathogenic mutation in exon 4 of the human amyloid precursor protein (APP) gene (1992) (12)
Prognostic value of the immunocytochemical detection of extramural venous invasion in Dukes' C colorectal adenocarcinomas. A preliminary study. (1989) (12)
Decoding Darkness: The Search for the Genetic Causes of Alzheimer’s Disease (2000) (12)
The double-edged role of copper in the fate of amyloid beta in the presence of anti-oxidants† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc01787a Click here for additional data file. (2017) (12)
Patterns of mucous secretion in normal and pathological conditions of the endocervix. (1986) (12)
O‐acetylated sialic acid variants in intestinal glandular metaplasia of the urinary tract (1986) (12)
A promising animal model of Alzheimer's disease. (1995) (12)
Follow‐up mapping supports the evidence for linkage in the candidate region at 9q22 in the NIMH Alzheimer's disease Genetics Initiative cohort (2007) (12)
Chromosomal localization of the mouse homolog of the Huntington's disease linked G8 (D4S10) marker. (1987) (11)
787 Association of the cytoplasmic domain of the β-amyloid protein with a novel human FE65-like protein (1996) (11)
The beta amyloid protein precursor: mRNAs, membrane-associated forms, and soluble derivatives. (1989) (11)
Search for the Genes Responsible for Familial Alzheimer's Disease (1993) (11)
Quantitative Analysis of Neuronal Dendritic Arborization Complexity in Drosophila. (2019) (11)
Change in Sense of Nondual Awareness and Spiritual Awakening in Response to a Multidimensional Well-Being Program. (2018) (11)
Apolipoprotein E4 impairs the response of neurodegenerative retinal microglia and prevents neuronal loss in glaucoma. (2022) (11)
Genetic and physical mapping of the GLUR5 glutamate receptor gene on human chromosome 21 (1994) (11)
Involvement of ubiquilin-1 transcript variants in protein degradation and accumulation (2011) (11)
γ‐Secretase modulators reduce endogenous amyloid β42 levels in human neural progenitor cells without altering neuronal differentiation (2015) (11)
Reduced amyloidogenic processing of the amyloid beta-protein precursor by the small-molecule Differentiation Inducing Factor-1. (2009) (10)
Adjusting heterogeneous ascertainment bias for genetic association analysis with extended families (2015) (10)
Non-Amyloid Approaches to Disease Modification for Alzheimer’s Disease: An EU/US CTAD Task Force Report (2020) (10)
Gga3 deletion and a GGA3 rare variant associated with late onset Alzheimer’s disease trigger BACE1 accumulation in axonal swellings (2020) (10)
A genetic linkage map of the chromosome 4 short arm (1993) (10)
Of calcium, caspases, and cognitive decline (1998) (10)
On the association analysis of genome‐sequencing data: A spatial clustering approach for partitioning the entire genome into nonoverlapping windows (2017) (10)
Drosophila Preparation and Longitudinal Imaging of Heart Function In Vivo Using Optical Coherence Microscopy (OCM). (2016) (10)
Exercise hormone irisin is a critical regulator of cognitive function (2021) (10)
Cytoplasmic Presenilin Aggregates in Proteasome Inhibitor‐treated Cells (2000) (9)
Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE/PS1ΔE9 murine model of Alzheimer’s disease (2017) (9)
Primary prevention recommendations to reduce the risk of cognitive decline (2022) (9)
Ubiquilin 1 Modulates Amyloid Precursor Protein Trafficking (2006) (9)
Studies of Amyloid β‐Protein Precursor Expression in Alzheimer's Disease (1991) (9)
Pseudogene of dihydrolipoyl succinyltransferase (E2k) found by PCR amplification and direct sequencing of rodent-human cell hybrid DNAs (1994) (9)
Mechanisms that synergistically regulate η-secretase processing of APP and Aη-α protein levels: relevance to pathogenesis and treatment of Alzheimer's disease. (2017) (9)
Natural Modulators of Amyloid-Beta Precursor Protein Processing. (2012) (9)
TMEM106B and CPOX are genetic determinants of cerebrospinal fluid Alzheimer's disease biomarker levels (2021) (9)
Ubiquilin-1 modulates γ-secretase-mediated ε-site cleavage in neuronal cells. (2013) (9)
A linkage map of three anonymous human DNA fragments and SOD‐1 on chromosome 21. (1985) (9)
Non-invasive red-light optogenetic control of Drosophila cardiac function (2020) (9)
Alzheimer's disease risk and the Interleukin‐1 genes (2000) (9)
Alzheimer's disease-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation (2010) (8)
Genetic Linkage Map for Chromosome 21 a (1985) (8)
Rapid Biomarker Screening of Alzheimer’s Disease by Interpretable Machine Learning and Graphene-Assisted Raman Spectroscopy (2021) (8)
RFLPS at the D21S19 locus of human chromosome 21. (1985) (8)
Sequence-tagged sites (STSs) for a set of mapped markers on chromosome 21. (1992) (8)
FlyNet 2.0: drosophila heart 3D (2D + time) segmentation in optical coherence microscopy images using a convolutional long short-term memory neural network. (2020) (8)
Zinc and Alzheimer's Disease: An Update. (1999) (8)
Etiological Clues from Gene Defects Causing Early Onset Familial Alzheimer’s Disease (1997) (8)
Studies of a DNA marker (G8) genetically linked to Huntington disease in British families (1986) (8)
An α-2-macroglobulin insertion-deletion polymorphism in Alzheimer disease (reply) (1999) (8)
Genetic studies of Alzheimer's disease: Lessons learned and future imperatives (1994) (8)
FE65 and FE65L1 amyloid precursor protein‐binding protein compound null mice display adult‐onset cataract and muscle weakness (2015) (7)
Segmentation of Drosophila heart in optical coherence microscopy images using convolutional neural networks (2018) (7)
Genetic linkage studies of human neurodegenerative disorders (1991) (7)
Characterization of an unusual and complex chromosome 21 rearrangement using somatic cell genetics and cloned DNA probes. (1989) (7)
Novel therapeutics for Alzheimer’s disease (2008) (7)
Molecular imaging of Alzheimer’s disease–related gamma-secretase in mice and nonhuman primates (2020) (7)
Genome‐wide association analysis of COVID‐19 mortality risk in SARS‐CoV‐2 genomes identifies mutation in the SARS‐CoV‐2 spike protein that colocalizes with P.1 of the Brazilian strain (2021) (7)
Alternatives to amyloid for Alzheimer's disease therapies—a symposium report (2020) (7)
Massachusetts Alzheimer's Disease Research Center: Progress and challenges (2015) (7)
Alteration of Vascular Endothelial Cadherin in Alzheimer’s Disease Patient and Mouse Model (2018) (7)
The GSM BPN-15606 as a Potential Candidate for Preventative Therapy in Alzheimer's Disease. (2020) (7)
Analysis of the beta-amyloid protein precursor of Alzheimer's disease: mRNAs and protein products. (1990) (6)
The Amyloid P-Protein Precursor and Its Mammalian Homologues (1994) (6)
Endotype reversal as a novel strategy for screening drugs targeting familial Alzheimer's disease (2022) (6)
Region-based analysis of rare genomic variants in whole-genome sequencing datasets reveal two novel Alzheimer’s disease-associated genes: DTNB and DLG2 (2021) (6)
624 Proteolytic processing of wild-type and mutant forms of presenilin 2 (1996) (6)
Maximizing the Power of Genome-Wide Association Studies: A Novel Class of Powerful Family-Based Association Tests (2009) (6)
Isolation of polymorphic DNA fragments from human chromosome 4. (1987) (6)
On the Meta-Analysis of Genome-Wide Association Studies: A Robust and Efficient Approach to Combine Population and Family-Based Studies (2012) (6)
An APP ectodomain mutation outside of the Aβ domain promotes Aβ production in vitro and deposition in vivo (2021) (6)
The Genetic Basis of Alzheimer's Disease: Findings From Genome-Wide Studies (2016) (6)
Nanoplasmonic fiber tip probe detects significant reduction of intracellular Alzheimer’s disease-related oligomers by curcumin (2017) (6)
Effects of Species-Specific Genetics on Alzheimer’s Mouse Models (2019) (6)
Negative Evidence for a Role of APH1B T27I Variant in Alzheimer's Disease. (2020) (6)
Genomic structure, expression pattern, and chromosomal localization of the human calsenilin gene: no association between an exonic polymorphism and Alzheimer's disease (2000) (5)
Regulation of key proteins in Alzheimer’s disease molecular pathogenesis by ubiquilin-1 (2013) (5)
Infection and inflammation: New perspectives on Alzheimer's disease (2022) (5)
Most Pathways Can Be Related to the Pathogenesis of Alzheimer’s Disease (2022) (5)
ACAT1 is not associated with Alzheimer's disease in two independent family-based samples (2005) (5)
The Alzheimer disease-associated amyloid beta protein precursor gene and familial Alzheimer disease. (1990) (5)
Genetic heterogeneity of gene defects responsible for familial Alzheimer disease. (1993) (5)
The Self-Directed Biological Transformation Initiative and Well-Being. (2016) (5)
Molecular Genetic Evidence for Etiologic Heterogeneity of Alzheimer’s Disease (1992) (5)
Neuroinflammatory Environments Promote Amyloid-ß Deposition and Posttranslational Modification (2003) (5)
Search for the familial Alzheimer's disease gene. (1987) (5)
Neurotechnological Approaches to the Diagnosis and Treatment of Alzheimer’s Disease (2022) (5)
TMEM106B and CPOX are genetic determinants of cerebrospinal fluid Alzheimer’s disease biomarker levels (2020) (5)
Lack of specific association of presenilin 1 (PS-1) protein with plaques and tangles in Alzheimer's disease (1998) (5)
Linkage analysis in familial Alzheimer disease: Description of the Duke and Boston data sets (1993) (5)
Degradation and inhibition of epigenetic regulatory protein BRD4 exacerbate Alzheimer’s disease-related neuropathology in cell models (2022) (5)
The neuroimmune axis of Alzheimer’s disease (2023) (4)
Manifestations of Alzheimer’s disease genetic risk in the blood are evident in a multiomic analysis in healthy adults aged 18 to 90 (2022) (4)
Molecular genetics of familial Alzheimer's disease. (1989) (4)
Correction: The Zinc Dyshomeostasis Hypothesis of Alzheimer's Disease (2012) (4)
Molecular Genetic Strategies in Familial Alzheimer’s Disease: Theoretical and Practical Considerations (1988) (4)
A morphometric study of cystadenolymphoma (Warthin's tumor). (1987) (4)
Visualization of Receptor-Interacting Protein Kinase 1 (RIPK1) by Brain Imaging with Positron Emission Tomography. (2021) (4)
Cerebral Zinc Metabolism in Alzheimer’s Disease (1997) (4)
The Genetic Basis of Alzheimer’s Disease (2016) (4)
Familial Alzheimer's Disease‐linked Mutant Presenilins Attenuate Capacitative Calcium Entry (2002) (4)
Corrigendum: Identification of Altered Metabolomic Profiles Following a Panchakarma-based Ayurvedic Intervention in Healthy Subjects: The Self-Directed Biological Transformation Initiative (SBTI) (2016) (3)
Patterning of interconnected human brain spheroids. (2021) (3)
Genetic Testing in the Early Diagnosis of Alzheimer’s Disease (2000) (3)
Dedifferentiation orchestrated through remodeling of the chromatin landscape defines PSEN1 mutation-induced Alzheimer’s Disease (2019) (3)
In vivo Early Detection of Alzheimer’s Disease-Linked Aβ Peptide Accumulation in the Lens Using Quasi-Elastic Light Scattering (2008) (3)
Neurodegenerative Diseases: Genetics of Alzheimer's disease (2005) (3)
Genetic Screening in Alzheimer's Disease (2000) (3)
G‐cell density in the antral mucosa: a feasibility study (1997) (3)
Decoding Alzheimer’s in the age of genome-wide analyses (2013) (3)
Author Correction: Tau molecular diversity contributes to clinical heterogeneity in Alzheimer’s disease (2021) (3)
149 The Presenilin 1 and 2 mutations linked to familial Alzheimer's Disease increase the extracellular concentration of amyloid 0 protein (Aβ) ending at Aβ42(43) (1996) (3)
S-4-2 Abnormal homeostasis of pH and Zinc: The prelude for cerebral Aβ amyloid formation? (1996) (3)
Human amyloid-derived aßcontains tyrosine cross-linked oligomers (2000) (3)
Design and synthesis of novel methoxypyridine-derived gamma-secretase modulators. (2020) (3)
In vitro comparison of major memory-support dietary supplements for their effectiveness in reduction/inhibition of beta-amyloid protein fibrils and tau protein tangles: key primary targets for memory loss (2021) (3)
DNA Markers in Familial Alzheimer’s Disease (1986) (3)
Unraveling the Genetics of Alzheimer Disease (2000) (3)
In Vivo Quasi-Elastic Light Scattering Eye Scanner Detects Molecular Aging in Humans and Mice (2018) (3)
Enhanced activity of Alzheimer disease-associated variant of protein kinase Cα drives cognitive decline in a mouse model (2021) (3)
522 Abnormal homeostasis of pH and zinc: The prelude for cerebral Aβ amyloid formation? (1996) (3)
PILRA polymorphism modifies the effect of APOE4 and GM17 on Alzheimer’s disease risk (2022) (2)
Small blood vessels or lymphatic channels with neoplastic microemboli: a comparative immunohistochemical study. (1986) (2)
O-acylated sialic acid variants in mucinous tumours of the ovary (2004) (2)
Alzheimer’s Disease: Causes, Mechanisms, and Steps Toward Prevention (2020) (2)
No association between marker D10S1423 and Alzheimer's disease (2003) (2)
A screening platform based on epitope editing for drug discovery (2019) (2)
Fluorinated Cromolyn Derivatives for Potential Alzheimer’s Disease Treatment (2019) (2)
Copper-mediated aggregation and polymerization of A-beta (1997) (2)
Immunohistochemical study of carcinoembryonic antigen, epithelial membrane antigen, and secretory immunoglobulin system in the large bowel adenoma-carcinoma sequence. (1986) (2)
Response to Mancuso et al.: Curcumin and Alzheimer Disease: This Marriage Is Not to Be Performed (2011) (2)
Animal Models of Alzheimer's Disease Should Be Controlled for Roseolovirus. (2020) (2)
Molecular genetics of human chromosome 4. (1986) (2)
Alzheimer’s disease amyloid-β pathology in the lens of the eye (2022) (2)
Correspondence to Sand et al. “Critical Reappraisal of a Catechol-O-Methyltransferase Transversion Variant in Schizophrenia” (2010) (2)
Discovery of Potent Gamma Secretase Modulators for the Treatment of Alzheimer’s Disease (2016) (2)
Goldstein and a Blast Neurotrauma Mouse Model Chronic Traumatic Encephalopathy in Blast-Exposed Military Veterans (2)
Characterizing Gene and Protein Crosstalks in Subjects at Risk of Developing Alzheimer’s Disease: A New Computational Approach (2017) (2)
α-Ketoglutarate Dehydrogenase in Alzheimer’s Disease (1996) (2)
New light on an old CLU (2010) (2)
Development of a potential PET probe for HDAC6 imaging in Alzheimer's disease (2022) (2)
Genetics of Neurodegenerative Diseases (2012) (2)
22 – Etiology, Genetics, and Pathogenesis of Alzheimer's Disease (2001) (2)
Enhanced redox interaction of copper-Aβ by homocysteine (2000) (2)
Your Brain is the Universe (Part 2) (2013) (2)
The neuronal-specific isoform of BIN1 regulates β-secretase cleavage of APP and Aβ generation in a RIN3-dependent manner (2022) (2)
3D Alzheimer's disease in a dish: Implications for drug discovery (2021) (2)
Adult neurogenesis in Alzheimer's disease (2023) (2)
Evaluation of Fluorinated Cromolyn Derivatives as Potential Therapeutics for Alzheimer's Disease. (2021) (2)
Non-Amyloid Approaches to Disease Modification for Alzheimer's Disease: An EU/US CTAD Task Force Report. (2020) (2)
Correction to Cathepsin L Mediates the Degradation of Novel APP C-Terminal Fragments. (2015) (2)
[Pulmonary carcinoma (microcytoma) with metastases in liver angiomas (cavernomas)]. (1976) (2)
Tissue evaluation of epithelial and functional markers of cell differentiation and mucins in colonic malignancy: assessment of diagnostic and prognostic value. (1988) (2)
THE EMERGING ANTIMICROBIAL PROTECTION HYPOTHESIS OF ALZHEIMER’S DISEASE (2017) (2)
Using Deep Learning to Identify Patients with Cognitive Impairment in Electronic Health Records (2021) (1)
[Lamellar osmiophilic bodies of type II alveolar cells in human and animal lung. Considerations on their origin, structure and function (author's transl)]. (1979) (1)
O4-01-08 Apolipoprotein E inhibits generation of neurotoxic cross-linked beta-amyloid species (CAPS) (2006) (1)
P1-379: In vivo detection of Alzheimer's disease–linked Aβ peptide accumulation in the lens (2008) (1)
The Diverse Molecular Nature of Inherited Alzheimer’s Disease (1994) (1)
Author Correction: Exercise hormone irisin is a critical regulator of cognitive function (2021) (1)
Two RFLPs detected by a cosmid at locus D16S144. (1990) (1)
Optogenetic Cardiac Control in Drosophila Using Red-light (2018) (1)
O3-01-02 Early, premorbid detection of beta-amyloid pathology by non-invasive in vivo quasi-elastic light scattering in the lens (2006) (1)
AN EXPLORATORY MOLECULAR IMAGING STUDY TARGETING Aβ WITH A NOVEL 8-OH QUINOLINE IN ALZHEIMER’S DISEASE (THE PBT2-204 IMAGINE STUDY) (2016) (1)
Assessment of Alzheimer's disease risk genes with CSF-biomarker levels (2013) (1)
Protein Processing through Altered Endocytic Trafficking (2011) (1)
Candidate Genes Showing No Evidence of Association with Alzheimer's Disease: Results of the NIMH‐AD Genetics Initiative (2002) (1)
Cytosolic β-amyloid deposition and supranuclear cataracts in lenses from people with down syndrome (2009) (1)
Regulation of key proteins in Alzheimer’s disease molecular pathogenesis by ubiquilin-1 (2013) (1)
The Impact of the Cellular Environment and Aging on Modeling Alzheimer's Disease in 3D Cell Culture Models (2023) (1)
Plasma IL‐12/IFN‐γ axis predicts cognitive trajectories in cognitively normal older adults (2020) (1)
S2-01-01 Systematic meta-analysis of Alzheimer’s disease genetic association studies - the AlzGene database (2006) (1)
Detailed genetic linkage map of human chromosome 21: patterns of recombination according to age and sex. (1990) (1)
Artefactual effects of lipid-based cell transfection reagents on AβPP processing and Aβ production (2006) (1)
RNAi-mediated knock-down of Dab and Numb attenuate Aβ levels via γ-secretase mediated APP processing (2012) (1)
Preclinical Prediction of AD: Relation Between Neuropsychological and Neuroimaging Findings (2002) (1)
IC-P-127 Non-invasive early detection of beta-amyloid molecular pathology by quasi-elastic light scattering in vivo (2006) (1)
Presenilin 2 — APP Interactions (1998) (1)
Adult hippocampal neurogenesis in Alzheimer's disease: A roadmap to clinical relevance. (2023) (1)
THE EXPRESSION OF ALZHEIMERʼS DISEASE CHROMOSOME 14Q24.3 GENE PRESENILIN-1(PS1) IN RAT BRAIN AND IN RESPONSE TO EXCITOTOXIC BRAIN INJURY (1996) (1)
Identification of Novel Alzheimer’s Disease Loci Using Sex-Specific Family-Based Association Analysis of Whole-Genome Sequence Data (2020) (1)
Molecular imaging of NAD+‐dependent deacetylase SIRT1 in the brain (2021) (1)
Candidate genes showing no evidence of association with Alzheimer disease — Results of the Nimh-Alzheimer disease genetics initiative (2000) (1)
Molecular Neurodegeneration: Basic biology and disease pathways (2013) (1)
[Adenolymphoma cystadenolymphoma) of the salivary glands. Review of 58 cases]. (1982) (1)
545 Characterization and analysis of presenilin 2 in mammalian cells: Normal role and effect of FAD-associated mutations (1996) (1)
A NOVEL DRUG-SCREENING PLATFORM IN MICROGLIAL CELLS IDENTIFIES POTENTIAL AD DRUGS (2017) (1)
Nutrient-induced Mitochondrial Activation (NiMA): A Novel Lysosome-to-Mitochondria Signaling Pathway Disrupted by Amyloid-β Oligomers (2018) (1)
Optogenetic control of Drosophila cardiac function with red-shifted opsins (Conference Presentation) (2018) (0)
S1-01-01 Regulating a-beta: clues from AD genetic studies (2004) (0)
Faculty Opinions recommendation of Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1. (2004) (0)
Modulators of expression and function of LRP in Alzheimer's disease (1997) (0)
The Alzheimer's Association, Connecticut Chapter and the members of the Medical Scientific Advisory Council cordially invite you to the 4th Annual Symposium for Advanced Professionals (2010) (0)
Synaptotagmins interact with APP and promote Aβ generation (2015) (0)
3D culture models of Alzheimer’s disease: a road map to a “cure-in-a-dish” (2016) (0)
Activated astrocytes may contribute to lower levels of soluble and aggregated β-amyloid in insulin-degrading enzyme knockout/APP transgenic mice (2009) (0)
Allele-specific miRNA mediated regulation of APP expression (2012) (0)
O2-03-05 (2006) (0)
The galvanization of p-amylc (2016) (0)
Impact and blast neurotrauma mouse models of chronic traumatic encephalopathy validated by human neuropathology (2013) (0)
Preliminary considerations on the identity of first and second-type alveolar cells in the human lung. (1976) (0)
Editorial Board (2007) (0)
602 The genes responsible for familial Alzheimer's disease: Toward a common etiological pathway (1996) (0)
An Integrated Optical Coherence Microscopy Imaging and Optical Stimulation System for Optogenetic Pacing in Drosophila melanogaster (2016) (0)
Molecular genetics ofhumanchromosome 4 (1986) (0)
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing (2019) (0)
Assessment of the interaction between presenilin 1 (PS1) and ubiquilin 1 splice variants in intact cells (2007) (0)
Meta-Analysis Evaluation of the Potential Excess of Statistically Significant Findings in Published Genetic Association Studies : Application to Alzheimer ’ s Disease (2008) (0)
Alzheimer ' s Disease Risk Factors in Yeast Toxicity , Endocytic Trafficking , and β Functional Links Between A (2013) (0)
Tau molecular diversity contributes to clinical heterogeneity in Alzheimer’s disease (2020) (0)
A smoothed version of the Lassosum penalty for fitting integrated risk models (2021) (0)
Mechanistic pathobiology of acute concussion, traumatic brain injury, and chronic traumatic encephalopathy in mouse models of blast neurotrauma and impact concussion (2015) (0)
A NOVEL LYSOSOME TO MITOCHONDRIA SIGNALING PATHWAY REGULATES MITOCHONDRIAL ACTIVITY AND IS DISRUPTED BY AMYLOID-β OLIGOMERS (2018) (0)
389 Phosphorylation of APLP2 in cell cycle-dependent manner (1996) (0)
A comparison between similarity matrices for principal component analysis to assess population stratification in sequenced genetic data sets (2022) (0)
Huntington's Disease Homozygotes (1987) (0)
Nutritional metabolism and cerebral bioenergetics in Alzheimer's disease and related dementias (2022) (0)
P1-375: Alzheimer's disease beta-amyloid pathology in Down syndrome cataract (2008) (0)
NeuraHealth: An Automated Screening Pipeline to Detect Undiagnosed Cognitive Impairment in Electronic Health Records with Deep Learning and Natural Language Processing (2022) (0)
Alternative Endoproteolysis of the Presenilins and Familial Alzheimer’s Disease (1998) (0)
Genetic linkage analysis and molecular characterization of candidate β-secretases, BACE1 and BACE2 (2000) (0)
Abnormal mitochondrial constituents coded by the nuclear genome in Alzheimer disease (1996) (0)
[Morphological studies using the optical and electron microscope and short histogenetic considerations on 8 cases of Wilms' tumor]. (1976) (0)
P3-262: Assessment of Alzheimer's disease case-control association findings in a large collection of family-based samples (2008) (0)
CRISPR/Cas9-Correctable mutation-related molecular and physiological phenotypes in iPSC-derived Alzheimer’s PSEN2N141I neurons (2017) (0)
University of Groningen Soluble gamma-secretase modulators attenuate Alzheimer's β-amyloid pathology and induce conformational changes in presenilin 1 Raven, (2017) (0)
CHARACTERIZATION OF BASAL FOREBRAIN CHOLINERGIC NEURONS FROM INDUCED PLURIPOTENT STEM CELLS HARBORING FAMILIAL ALZHEIMER’S MUTATION PSEN2 N141I (2016) (0)
527 Modulation of Aβ and mutant aggregation in vitro by zinc and pH (1996) (0)
546 Detection of wild-type and mutant forms of presenilin 1 in mammalian cell membranes (1996) (0)
Regulation of APP metabolism by the Rho GTPase cdc42 (2009) (0)
[The concept of the adenoma-carcinoma sequence in the colon and rectum: histochemical and immunohistochemical study]. (1985) (0)
Pleiotropy genes affect multiple and apparently unrelated phenotypes. Here we describe pleiotropy gene presenilins, mutations in which have been detected in three genetically heterogeneous diseases: early-onset familial Alzheimer's disease, familial or sporadic dilated cardiomyopathy, and familial h (2013) (0)
Optogenetic pacing in Drosophila melanogaster (Conference Presentation) (2016) (0)
P1-204 Effects of ubiquilin-1 RNA interference (RNA1) on APP processing (2004) (0)
Pbt2 for Pre-dementia Alzheimer's Disease: Animal and Clinical Evidence (2009) (0)
Faculty of 1000 evaluation for Anti-aβ therapeutics in Alzheimer's disease: the need for a paradigm shift. (2011) (0)
Beta–Amyloid Lens Pathology and Alzheimer's–Like Equatorial Supranuclear/Deep Cortical Cataracts in Down's Syndrome (Trisomy 21) (2006) (0)
O1-03-03: Reduced β-amyloid deposition in amyloid precursor protein transgenic mice lacking the insulin-degrading enzyme (2008) (0)
Author Correction: The neuronal-specific isoform of BIN1 regulates β-secretase cleavage of APP and Aβ generation in a RIN3-dependent manner (2022) (0)
Hypoxia, Hypocapnia and Presenilin 1-Related Cellular Apoptosis: [2002][A-798] (2002) (0)
Presenilin 1 processing in cholesterol mutant cells treated with proteasome inhibitors (2000) (0)
Identification of clusters of rapid and slow decliners among subjects at risk for Alzheimer’s disease (2017) (0)
Science Signaling Podcast for 10 May 2016: PKCα in Alzheimer’s disease (2016) (0)
Natural medicine HLXL targets multiple pathways of amyloid-mediated neuroinflammation and immune response in treating alzheimer's disease. (2022) (0)
Studies on parathyroid scintiphotography (1976) (0)
Physical mapping of human chromosome 22 using yeast artificial chromosomes (1991) (0)
LOSS-OF-FUNCTION OF ATXN1 INCREASES A β LEVELS BY POTENTIATING β SECRETASE PROCESSING OF APP (2009) (0)
ALZHEIMER’S DISEASE Advances in Genetics, Molecular and Cellular Biology ALZHEIMER’S DISEASE Advances in Genetics, Molecular and Cellular Biology (2013) (0)
ORAL SESSIONS O2-12 MOLECULAR AND CELL BIOLOGY: CELL BIOLOGYAND PHYSIOLOGY O2-12-01 LYSOSOMAL DYSFUNCTION AND ALTERED TAU METABOLISM IN STEM CELL MODELS OFAUTOSOMAL DOMINANTALZHEIMER’S DISEASE (2018) (0)
Optogenetic pacing in Drosophila melanogaster this article openly available. Please share how this access benefits you. Your story matters (2015) (0)
P4-193 Increased activity of β-amyloidogenic secretases via stabilization of BACE and γ-secretase complex components during apoptosis (2004) (0)
A Matter of Timing: Rudy Tanzi on Alzheimer's Disease (2022) (0)
S1-04-02: Genetic association studies in Alzheimer's disease (2008) (0)
Cardiac optogenetic pacing in drosophila melanogaster using red-shifted opsins (Conference Presentation) (2017) (0)
Impact of FE651, an APP- and LRP-binding protein, on the endocytic function of LRP (2000) (0)
Isolation ofpolymorphic DNA segments fromhumanchromosome 21 (1985) (0)
O2-02-08: Dimeric cross-linked Abeta species disrupt and oxidize membranes (2008) (0)
P2‐032: Withdrawn (2015) (0)
Heartbeat recovery after cardiac arrest and association of maximum pace-able heart rate with aging via optogenetic pacing and OCM imaging of Drosophila (Conference Presentation) (2020) (0)
IC-P-118 Vascular risks and MRI measures of white matter hyperintensities and brain atrophy in the prediction of cognitive decline (2006) (0)
In situ hybridization analysis of presenilin 1 mRNA in Alzheimer disease and in lesioned rat brain (hippocampal formationyexcitotoxic lesion) (1996) (0)
Use of Victoria blue in the detection of intrahepatocyte HBs Ag: comparison with other methods. (1984) (0)
The regulation of caspase-3 at the synapse. (2011) (0)
P4-102 Functional analysis of the insulin degrading enzyme in genetically-associated AD families (2004) (0)
Sex Differences in Cognitive Decline in Subjects with High Likelihood of Mild Cognitive Impairment due to Alzheimer’s disease (2018) (0)
Neuronal Intranuclear Inclusions Minireview in Polyglutamine Diseases: Nuclear Weapons or Nuclear Fallout? (1998) (0)
Loss of Ataxin-1 Elevates BACE1 Expression and Impairs Axonal Targeting in the Cerebrum (2018) (0)
Optogenetic Cardiac Pacing (2021) (0)
P3-368 Endogenous human APP possesses oxidase activity (2006) (0)
Reporting amyloid beta levels via bioluminescence imaging with amyloid reservoirs in Alzheimer’s disease models (2021) (0)
Gut microbiome perturbations influence brain amyloidosis only in the presence of microglia in APPPS1‐21 mice (2020) (0)
The Double-Edges Role of Copper in the Fate of Amyloid Beta in the Presence of Anti-Oxidants (2021) (0)
Optogenetic Cardiac Pacing and Its Applications (2021) (0)
Beta-amyloid oligomers for use in the treatment, alleviation or prevention of Alzheimer's disease (2001) (0)
Genetic basis of cerebral amyloidosis (2005) (0)
Effects of presenilin mutations on γ-secretase cleavage and turnover of the amyloid β-protein precursor C-terminal fragment (2000) (0)
From the amyloid β protein (A4) to isolation of the first Alzheimer’s disease gene: amyloid β (A4) precursor protein (APP) (2006) (0)
Volume TOC (2004) (0)
Upregulation of Alzheimer’s amyloid- β protein precursor in astrocytes both in vitro and in vivo (2020) (0)
Non–Invasive Molecular Imaging of Alzheimer’s Disease ß–Amyloid and Scrapieform Prion Protein (Prpsc) in the Lens (2006) (0)
P4-402 Alzheimer's disease drug discovery targeted to the APP MRNA 5′ untranslated region, a validated target (2004) (0)
A Serine Protease Inhibitor Domain Encoded Within the Alzheimer Disease-Associated Amyloid ß-Protein Precursor Gene (1990) (0)
Diabetes-linked SORCS1, a gamma-secretase substrate and regulator of Alzheimer APP metabolism, forms complexes with multiple Alzheimer-linked proteins (APP, PS1, BACE, VPS35, and SORLA) (2010) (0)
IC-P-071 The effect of APOE-4 on fMRI deactivation in older controls, MCI subjects and AD patients (2006) (0)
Genetic Studies of the Alzheimer’s Disease-Associated Amyloid β-Protein Precursor Gene and Familial Alzheimer’s Disease (1989) (0)
Abnormal conditions in AD brain may modulate LRP-mediated catabolism of Aβand APP (2000) (0)
Novel PKC signaling in Alzheimer’s Disease (2022) (0)
P4-119 Genetic association of UBQLN1 and Alzheimer's disease in multiple independent study populations (2004) (0)
Caspase Activation Increases (cid:1) -Amyloid Generation Independently of Caspase Cleavage of the (cid:1) -Amyloid Precursor Protein (APP)* (2003) (0)
Microfluidic separation of axonal and somal compartments of neural progenitor cells differentiated in a 3D matrix (2022) (0)
Presenilin-containing aggresome formation in cholesterol mutant cells (2000) (0)
Molecular andCytogenetic Characterization ofa DeNovot(Sp;21q) ina Patient Previously Diagnosed as Monosomy21 (1988) (0)
216. The effect of amyloid precursor protein and presenilin mutations on amyloid beta protein (1996) (0)
An integrated optical coherence microscopy imaging and optical stimulation system for optogenetic pacing in Drosophila melanogaster (Conference Presentation) (2016) (0)
Role of intracellular cholesterol compartmentation in APP processing and Aβgeneration (2000) (0)
Pharmacological and Toxicological Properties of the Potent Oral g -Secretase Modulator BPN-15606 s (2017) (0)
Modeling and elucidating the pathobiology of blast-induced traumatic brain injury in the mouse (2013) (0)
Effects of staurosporine-mediated cell death on aβproduction and caspase-mediated cleavage of amyloid precursor protein and presenilins (2000) (0)
P2-357 Vascular risks and MRI measures of white matter hyperintensities and brain atrophy in the prediction of cognitive decline (2006) (0)
O2-02-08 Levels of autoantibodies to redox-modified abeta are attenuated in the plasma of Alzheimer's disease patients (2004) (0)
Genome-wide screening for novel Alzheimer's disease genes: What have we found? (2009) (0)
Nanoplasmonic fiber tip probe detects significant reduction of intracellular Alzheimer’s disease-related oligomers by curcumin (2017) (0)
Epitope alteration by small molecules and applications in drug discovery (2022) (0)
Decoding Alzheimer’s in the age of genome-wide analyses (2013) (0)
Inhibition of capacitative calcium entry pathway potentiates presenilin-associated ‘-secretase activities of the amyloid β-precursor protein and Notch (2000) (0)
79 What are genetic studies teaching us about how to treat Alzheimer's disease? (2012) (0)
O4-01-02 The effect of APOE-4 on fMRI deactivation in older controls, MCI subjects and AD patients (2006) (0)
Clinical phenotype of chromosome 14q24 associated FAD in the Italian-American (Feldman FAD Family) pedigree (1994) (0)
Alzheimer’s disease β-amyloid protein precursor is a ferroxidase that promotes iron export (2009) (0)
The Amazon rain forest plant Uncaria tomentosa (cat’s claw) and its specific proanthocyanidin constituents are potent inhibitors and reducers of both brain plaques and tangles (2019) (0)
Rapid removal of amyloid-β aggregates using superparamagnetic nanoparticles (2019) (0)
iPSC-derived familial Alzheimer’s PSEN2N141I cholinergic neurons exhibit mutation-dependent molecular pathology corrected by insulin signaling (2018) (0)
Invited Editorial: GeneMutations inInherited Amyloidopathies oftheNervousSystem (1991) (0)
P4-182 BACE1 is degraded via the lysosomal pathway (2004) (0)
P1-131 (Aβ) in human lens & aqueous humor: further characterization of a novel AD biomarker (2004) (0)
A NOVEL PHARMACOLOGICAL INTERVENTION TO NEUROINFLAMMATORY OUTCOMES OF AIR POLLUTION: THE GAMMA SECRETASE MODULATOR BPN-15606 ATTENUATED MICROGLIAL AND AMYLOID INDUCTION BY URBAN NANO-PARTICULATE (NPM) IN YOUNG MALE C57BL/6J MICE (2019) (0)
Non-invasive red light optogenetic pacing and optical coherence microscopy (OCM) imaging for drosophila melanogaster (Conference Presentation) (2017) (0)
Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study (2020) (0)
P1-354 Cross sectional and longitudinal analysis of Alzheimer’s disease quantitative phenotypes (2006) (0)
IN VIVO ASSESSMENT OF MOLECULAR AGING BY QUASI-ELASTIC LIGHT SCATTERING IN HUMAN LENS (2016) (0)
O2-03-05 Early detection of Alzheimer’s disease-linked aβ peptide accumulation in the lens by non-invasive quasi-elastic light scattering (2007) (0)
Intrinsic ferroxidase activity in the Alzheimer's amyloid precursor protein (2000) (0)
In vivo Detection of Early Alzheimer's Disease-Linked Aβ Peptide Accumulation in the Lens by Non-Invasive Quasi-Elastic Light Scattering (2010) (0)
Guest editor’s introduction (2007) (0)
Early Detection of Alzheimer’s Disease-Linked Aß Peptide Accumulation in the Lens by Non-Invasive Quasi-Elastic Light Scattering (2007) (0)
microRNA-mediated regulation of APP expression (2010) (0)
The Telomere Connection (2018) (0)
Cardiac recovery after pacing as an indicator of cardiac health in Drosophila (Conference Presentation) (2019) (0)
P4-114 Protection from AD by the XMNI gamma (G) polymorphism may be mediated by interactions between vascular AB1-42 and methemoglobin (2004) (0)
Optogenetic Pacing: Current Insights and Future Potential (2020) (0)
Expression and Further Characterization of Alzheimer's Disease Beta-amyloid (Abeta) in Human Aqueous Humor and Lens (2003) (0)
Effect of familial Alzheimer's disease mutations on the formation of presenilin aggregates in proteasome inhibitor treated cells (2000) (0)
[Use of anti-keratin antibodies in the definition of the grading of laryngeal carcinoma and the study of micro-metastases of the lymph nodes]. (1987) (0)
Lack of hepatic apoE does not influence early Aβ deposition: observations from a new APOE knock-in model (2019) (0)
AMYLOID PROTEIN PRECURSOR mRNA LACKING THE KUNITZ PROTEASE INHIBITOR SEQUENCE INCREASES IN AD NUCLEUS BASALIS AND LOCUS CERULEUS NEURONS (1988) (0)
Genetic analysis of the FE65 intron 13 biallelic polymorphism in a family-based and a case control study (2000) (0)
Second Generation Laser Ophthalmic Technology for Quantitative Non-Invasive Detection of Alzheimer’s Disease Molecular Pathology in the Lens (2009) (0)
Completamente automatizzata la procedura di amplificazione del DNA mediante Polymerase Chain Reaction (PCR) (1988) (0)
The Role of the Presenilins in Alzheimer's Disease (1998) (0)
Amyloid-β42/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer’s disease (2020) (0)
HtrA2Regulates-AmyloidPrecursorProtein(APP)Metabolism throughEndoplasmicReticulum-associatedDegradation *□ (2007) (0)
Regulation of Epigenetic BET Proteins on Alzheimer’s Disease in Preclinical Models (2022) (0)
Protective Alzheimer's disease-associated APP A673T variant predominantly decreases sAPPβ levels in cerebrospinal fluid and 2D/3D cell culture models (2023) (0)
Cromolyn Reduces Levels of the Alzheimer’s Disease-Associated Amyloid β-Protein by Promoting Microglial Phagocytosis (2018) (0)
Protein Aggregation and Human Disorders (2006) (0)
P1-128 Non-invasive early detection of beta-amyloid molecular pathology by quasi-elastic light scattering in vivo (2006) (0)
d role of copper in the fate of amyloid beta in the presence of antioxidants † (2017) (0)
The Amyloid Precursor Protein V717I Mutation Increases Susceptibility to Cell Death in a Cholesterol‐dependent Manner (2002) (0)
A Smoothed Version of the Lassosum Penalty for Fitting Integrated Risk Models Using Summary Statistics or Individual-Level Data (2022) (0)
Reply to Neupane et al.: Replication study of AD‐associated rare variants (2022) (0)
Faculty of 1000 evaluation for Will the ubiquitin system furnish as many drug targets as protein kinases (2010) (0)
Chapter 8:Biological Metals: Metallostasis and Alzheimer's Disease (2011) (0)
Human Neurospheroid Arrays for In Vitro Studies of Alzheimer’s Disease (2018) (0)
Studies on pancreatic scintiphotography (1975) (0)
The Common Inhalation Anesthetic Isoﬂurane Induces Apoptosis and Increases Amyloid (cid:1) Protein Levels (2006) (0)
Design, synthesis, and anti-inflammatory activity characterization of novel brain-permeable HDAC6 inhibitors. (2023) (0)
Keystone Symposia Meeting, Part 1—Alzheimer’s Disease: Genes, Cellular Pathways and Therapies (2006) (0)
P1-274 In search of novel Alzheimer’s disease genes on chromosome 19 (2006) (0)
Characterization and Non–Invasive Imaging of Lens ß–Amyloid in the Tg2576 Mouse Model of Alzheimer's Disease (2005) (0)
Significant association of coding (Missense) SNPs with familial LOAD based on a functional genome-wide association screen (2011) (0)
O2-03-03: Depletion of GGA3 regulates BACE in vivo (2008) (0)
Gutmicrobiome perturbations influence brain amyloidosis only in the presence ofmicroglia in APPPS1-21mice (2020) (0)
A novel Alzheimer's disease model based on 3D-cultured human neural progenitor cells (2013) (0)
NOVEL GAMMA-SECRETASE MODULATOR REGULATES APP PROCESSING AND INFLAMMATORY RESPONSES IN NPM-EXPOSED MICE (2019) (0)
RETRACTED: Genome-wide assessment of copy number variations in early-onset Alzheimer's disease (2011) (0)
RECONSTRUCTING ALZHEIMER AMYLOID AND TAU PATHOLOGY IN 3D CELL CULTURES FROM STEM CELLS (2016) (0)
Correction: The Zinc Dyshomeostasis Hypothesis of Alzheimer's Disease (2013) (0)
Endogenous human APP possesses oxidase activity (2006) (0)
Why publish single observations? Because Science Matters. (2016) (0)
Alzheimer disease DNA sequence variants in APP Role of common and rare (2012) (0)
GENETIC ANALYSIS OF THE ALZHEIMER'S ASSOCIATED AMYLOID BETA PEPTIDE GENE (1988) (0)
Beta-Amyloid Promotes Lens Protein Aggregation and is Associated with Supranuclear Lens Opacification (2002) (0)
Immunohistochemical Evaluation of epithelial markers (IgAs, SC, EMA and CEA) in the adenoma-carcinoma sequence of the large bowel. (1983) (0)
Anticorps anti-oligomeres reticules de la proteine $g(b)-amyloide (2005) (0)
Retromer proteins reduced in Down syndrome and the Dp16 model: impact of APP dose and preclinical studies of a γ-secretase modulator. (2023) (0)
P3-325: Alzheimer's disease β-amyloid protein precursor is ferroxidase II, a ceruloplasmin-like iron detoxification enzyme (2008) (0)
P1-281 Genetic association analysis of BACE2 with Alzheimer’s disease (2006) (0)
Faculty Opinions recommendation of LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms. (2004) (0)
The Roles of Zinc and Copper in the Function and Metabolism of the Amyloid Protein Precursor Superfamily (1994) (0)

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