Russell S. Thomas

Researcher

Why Is Russell S. Thomas Influential?

Russell S. Thomas's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Papers

The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models (2010) (453)
ToxCast Chemical Landscape: Paving the Road to 21st Century Toxicology. (2016) (388)
Integration of dosimetry, exposure, and high-throughput screening data in chemical toxicity assessment. (2012) (345)
A comparison of batch effect removal methods for enhancement of prediction performance using MAQC-II microarray gene expression data (2010) (272)
Incorporating human dosimetry and exposure into high-throughput in vitro toxicity screening. (2010) (236)
Integrated Model of Chemical Perturbations of a Biological Pathway Using 18 In Vitro High-Throughput Screening Assays for the Estrogen Receptor. (2015) (221)
Screening Chemicals for Estrogen Receptor Bioactivity Using a Computational Model. (2015) (212)
Incorporating New Technologies Into Toxicity Testing and Risk Assessment: Moving From 21st Century Vision to a Data-Driven Framework (2013) (203)
Estimating toxicity-related biological pathway altering doses for high-throughput chemical risk assessment. (2011) (202)
Incorporating High-Throughput Exposure Predictions With Dosimetry-Adjusted In Vitro Bioactivity to Inform Chemical Toxicity Testing (2015) (183)
A method to integrate benchmark dose estimates with genomic data to assess the functional effects of chemical exposure. (2007) (156)
BMDExpress: a software tool for the benchmark dose analyses of genomic data (2007) (149)
The Next Generation Blueprint of Computational Toxicology at the U.S. Environmental Protection Agency. (2019) (148)
Temporal concordance between apical and transcriptional points of departure for chemical risk assessment. (2013) (138)
IVT-seq reveals extreme bias in RNA sequencing (2014) (136)
Development and Validation of a Computational Model for Androgen Receptor Activity (2016) (135)
A comprehensive statistical analysis of predicting in vivo hazard using high-throughput in vitro screening. (2012) (132)
Genome-wide analysis of human HSF1 signaling reveals a transcriptional program linked to cellular adaptation and survival. (2006) (124)
Editor's Highlight: Analysis of the Effects of Cell Stress and Cytotoxicity on In Vitro Assay Activity Across a Diverse Chemical and Assay Space. (2016) (122)
In vitro and modelling approaches to risk assessment from the U.S. Environmental Protection Agency ToxCast programme. (2014) (118)
Relative impact of incorporating pharmacokinetics on predicting in vivo hazard and mode of action from high-throughput in vitro toxicity assays. (2013) (114)
Formaldehyde: integrating dosimetry, cytotoxicity, and genomics to understand dose-dependent transitions for an endogenous compound. (2010) (112)
Application of transcriptional benchmark dose values in quantitative cancer and noncancer risk assessment. (2011) (112)
Toxicokinetic Triage for Environmental Chemicals. (2015) (110)
Aryl Hydrocarbon Receptor Regulates Cell Cycle Progression in Human Breast Cancer Cells via a Functional Interaction with Cyclin-Dependent Kinase 4 (2010) (108)
Predicting hepatotoxicity using ToxCast in vitro bioactivity and chemical structure. (2015) (107)
A multi-stakeholder perspective on the use of alternative test strategies for nanomaterial safety assessment. (2013) (107)
Activation of the aryl-hydrocarbon receptor inhibits invasive and metastatic features of human breast cancer cells and promotes breast cancer cell differentiation. (2010) (105)
The US Federal Tox21 Program: A strategic and operational plan for continued leadership. (2018) (105)
Recommended approaches in the application of toxicogenomics to derive points of departure for chemical risk assessment (2016) (102)
Genome-scale functional profiling of the mammalian AP-1 signaling pathway (2003) (100)
Accelerating the Pace of Chemical Risk Assessment. (2018) (99)
Evaluating In Vitro-In Vivo Extrapolation of Toxicokinetics (2018) (95)
Genomic signatures and dose-dependent transitions in nasal epithelial responses to inhaled formaldehyde in the rat. (2008) (92)
Utility of In Vitro Bioactivity as a Lower Bound Estimate of In Vivo Adverse Effect Levels and in Risk-Based Prioritization. (2019) (91)
Analysis of the Effects of Cell Stress and Cytotoxicity onIn Vitro Assay Activity Across a Diverse Chemical and Assay Space (2016) (84)
BMDExpress 2: enhanced transcriptomic dose-response analysis workflow (2018) (83)
Aryl hydrocarbon receptor deficiency causes dysregulated cellular matrix metabolism and age-related macular degeneration-like pathology (2013) (77)
Dose-dependent transitions in Nrf2-mediated adaptive response and related stress responses to hypochlorous acid in mouse macrophages. (2009) (77)
Integrating pathway-based transcriptomic data into quantitative chemical risk assessment: a five chemical case study. (2012) (77)
EDGE: A Centralized Resource for the Comparison, Analysis, and Distribution of Toxicogenomic Information (2005) (74)
Quantitative analyses and transcriptomic profiling of circulating messenger RNAs as biomarkers of rat liver injury (2010) (73)
Systematically evaluating read-across prediction and performance using a local validity approach characterized by chemical structure and bioactivity information. (2016) (72)
The Next Generation of Risk Assessment Multi-Year Study—Highlights of Findings, Applications to Risk Assessment, and Future Directions (2016) (71)
Incorporating population variability and susceptible subpopulations into dosimetry for high-throughput toxicity testing. (2014) (70)
Identification of chemical modulators of the constitutive activated receptor (CAR) in a gene expression compendium (2015) (69)
Sequence variation and phylogenetic history of the mouse Ahr gene. (2002) (67)
Cross-species comparisons of transcriptomic alterations in human and rat primary hepatocytes exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. (2012) (65)
Suspect Screening Analysis of Chemicals in Consumer Products. (2018) (63)
Application of genomic biomarkers to predict increased lung tumor incidence in 2-year rodent cancer bioassays. (2007) (62)
Knockout of the aryl hydrocarbon receptor results in distinct hepatic and renal phenotypes in rats and mice. (2013) (61)
Using ToxCast™ Data to Reconstruct Dynamic Cell State Trajectories and Estimate Toxicological Points of Departure (2015) (59)
The Tox21 10K Compound Library: Collaborative Chemistry Advancing Toxicology (2020) (58)
Identification of Modulators of the Nuclear Receptor Peroxisome Proliferator-Activated Receptor α (PPARα) in a Mouse Liver Gene Expression Compendium (2015) (55)
Regulation of aryl hydrocarbon receptor function by selective estrogen receptor modulators. (2010) (55)
Technical guide for applications of gene expression profiling in human health risk assessment of environmental chemicals. (2015) (55)
The Human Toxome Project (2015) (54)
The SEURAT-1 approach towards animal free human safety assessment. (2015) (53)
Use of short-term transcriptional profiles to assess the long-term cancer-related safety of environmental and industrial chemicals. (2009) (51)
Expression profiling in canine osteosarcoma: identification of biomarkers and pathways associated with outcome (2010) (51)
Comparison of microarrays and RNA-seq for gene expression analyses of dose-response experiments. (2014) (49)
A comparison of transcriptomic and metabonomic technologies for identifying biomarkers predictive of two-year rodent cancer bioassays. (2007) (48)
An integrated genomic analysis of aryl hydrocarbon receptor-mediated inhibition of B-cell differentiation. (2010) (48)
New directions in incidence-dose modeling. (2005) (46)
A Chemical Category-Based Prioritization Approach for Selecting 75 Per- and Polyfluoroalkyl Substances (PFAS) for Tiered Toxicity and Toxicokinetic Testing (2019) (46)
Functional analysis of multiple genomic signatures demonstrates that classification algorithms choose phenotype-related genes (2010) (44)
Genome-wide analysis of DNA methylation and gene expression changes in the mouse lung following subchronic arsenate exposure. (2010) (44)
Comprehensive Analyses and Prioritization of Tox21 10K Chemicals Affecting Mitochondrial Function by in-Depth Mechanistic Studies (2018) (43)
Screening a mouse liver gene expression compendium identifies modulators of the aryl hydrocarbon receptor (AhR). (2015) (43)
Systems pharmacology assessment of the 5-fluorouracil pathway. (2011) (43)
Food for Thought … Systems Toxicology (2012) (40)
Aryl hydrocarbon receptor knock-out exacerbates choroidal neovascularization via multiple pathogenic pathways (2014) (40)
The aryl hydrocarbon receptor interacts with ATP5α1, a subunit of the ATP synthase complex, and modulates mitochondrial function. (2011) (40)
A bistable switch underlying B-cell differentiation and its disruption by the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin. (2010) (40)
Chemical mixture toxicology: from descriptive to mechanistic, and going on to in silico toxicology. (2004) (39)
Considerations for Strategic Use of High-Throughput Transcriptomics Chemical Screening Data in Regulatory Decisions. (2019) (39)
Editor's Highlight: Application of Gene Set Enrichment Analysis for Identification of Chemically Induced, Biologically Relevant Transcriptomic Networks and Potential Utilization in Human Health Risk Assessment (2017) (38)
Assessing Toxicokinetic Uncertainty and Variability in Risk Prioritization. (2019) (38)
SEURAT: Safety Evaluation Ultimately Replacing Animal Testing—Recommendations for future research in the field of predictive toxicology (2014) (37)
Physiologically based pharmacokinetic/pharmacodynamic modeling of the toxicologic interaction between carbon tetrachloride and Kepone (1996) (36)
Genomic analysis of human lung fibroblasts exposed to vanadium pentoxide to identify candidate genes for occupational bronchitis (2007) (36)
Using the concordance of in vitro and in vivo data to evaluate extrapolation assumptions (2019) (34)
Dose-response modeling in reproductive toxicology in the systems biology era. (2005) (34)
High-Throughput Transcriptomics Platform for Screening Environmental Chemicals. (2021) (34)
On selecting a minimal set of in vitro assays to reliably determine estrogen agonist activity (2017) (33)
Predicting Organ Toxicity Using in Vitro Bioactivity Data and Chemical Structure. (2017) (33)
Chemical Risk Assessment: Traditional vs Public Health Perspectives (2017) (33)
Application of genomics to toxicology research. (2002) (32)
Lineage-dependent effects of aryl hydrocarbon receptor agonists contribute to liver tumorigenesis (2015) (30)
Systems Biology and Biomarkers of Early Effects for Occupational Exposure Limit Setting (2015) (29)
Evaluation of gene expression changes in human primary uroepithelial cells following 24‐Hr exposures to inorganic arsenic and its methylated metabolites (2013) (27)
Profiling the ToxCast library with a pluripotent human (H9) stem cell line-based biomarker assay for developmental toxicity. (2020) (26)
Cross-species transcriptomic analysis of mouse and rat lung exposed to chloroprene. (2013) (26)
Regulation of Bach2 by the aryl hydrocarbon receptor as a mechanism for suppression of B-cell differentiation by 2,3,7,8-tetrachlorodibenzo-p-dioxin. (2011) (26)
mRNA transfection retrofits cell-based assays with xenobiotic metabolism. (2018) (24)
Aryl hydrocarbon receptor knockout rats are insensitive to the pathological effects of repeated oral exposure to 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (2016) (23)
MYC Is an Early Response Regulator of Human Adipogenesis in Adipose Stem Cells (2014) (22)
Stochastic Modeling of B Lymphocyte Terminal Differentiation and Its Suppression by Dioxin (2010) (22)
A functional map of NFκB signaling identifies novel modulators and multiple system controls (2007) (20)
BMDExpress Data Viewer ‐ a visualization tool to analyze BMDExpress datasets (2015) (20)
Biological Networks for Predicting Chemical Hepatocarcinogenicity Using Gene Expression Data from Treated Mice and Relevance across Human and Rat Species (2013) (20)
Progress Towards an OECD Reporting Framework for Transcriptomics and Metabolomics in Regulatory Toxicology. (2021) (20)
Research toward the development of a biologically based dose response assessment for inorganic arsenic carcinogenicity: a progress report. (2007) (20)
Hexabromocyclododecane (HBCD): A case study applying tiered testing for human health risk assessment. (2019) (19)
Variability in in vivo studies: Defining the upper limit of performance for predictions of systemic effect levels. (2020) (18)
Subchronic toxicity evaluation of potassium bromate in Fischer 344 rats. (2013) (18)
Stochastic simulation of hepatic preneoplastic foci development for four chlorobenzene congeners in a medium-term bioassay. (2003) (16)
All-or-none suppression of B cell terminal differentiation by environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin. (2013) (14)
Immunological characterization of the aryl hydrocarbon receptor (AHR) knockout rat in the presence and absence of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). (2016) (14)
NetAtlas: A Cytoscape Plugin to Examine Signaling Networks Based on Tissue Gene Expression (2008) (13)
EXCESS workshop: Descriptions of rising low-energy spectra (2022) (13)
The Aryl-Hydrocarbon Receptor Protein Interaction Network (AHR-PIN) as Identified by Tandem Affinity Purification (TAP) and Mass Spectrometry (2013) (13)
A conditional density error model for the statistical analysis of microarray data (2002) (12)
Workflow for defining reference chemicals for assessing performance of in vitro assays. (2018) (12)
Case Studies in Cellular Stress: Defining Adversity/Adaptation Tipping Points (2017) (11)
Biological responses in rats exposed to cigarette smoke and Middle East sand (dust) (2012) (10)
Immune cell-based screening assay for response to anticancer agents: applications in pharmacogenomics (2015) (10)
Subchronic Hepatotoxicity Evaluation of Hydrazobenzene in Fischer 344 Rats (2012) (9)
Systems toxicology. (2012) (9)
Risk science in the 21st century: a data-driven framework for incorporating new technologies into chemical safety assessment (2017) (9)
In utero exposure to chloroquine alters sexual development in the male fetal rat. (2009) (8)
Comment on “On the Utility of ToxCast™ and ToxPi as Methods for Identifying New Obesogens” (2017) (8)
The Alginate Immobilization of Metabolic Enzymes (AIME) Platform Retrofits an Estrogen Receptor Transactivation Assay with Metabolic Competence. (2020) (8)
Assessing bioactivity-exposure profiles of fruit and vegetable extracts in the BioMAP profiling system. (2019) (8)
Development of an In Vitro Human Thyroid Microtissue Model for Chemical Screening. (2019) (8)
Developing toxicologically predictive gene sets using cDNA microarrays and Bayesian classification. (2002) (7)
Development of 3D dynamic flow model of human liver and its application to prediction of metabolic clearance of 7-ethoxycoumarin. (2014) (7)
Subchronic hepatotoxicity evaluation of bromobenzene in Fischer 344 rats (2013) (7)
A genomics-based analysis of relative potencies of dioxin-like compounds in primary rat hepatocytes. (2013) (7)
Loss of Hif-2α Rescues the Hif-1α Deletion Phenotype of Neonatal Respiratory Distress In Mice (2015) (6)
Subchronic Hepatotoxicity Evaluation of 1,2,4-Tribromobenzene in Sprague-Dawley Rats (2012) (5)
A cellular genetics approach identifies gene-drug interactions and pinpoints drug toxicity pathway nodes (2014) (5)
Toxicogenomics in Predictive Carcinogenicity (2016) (5)
Subchronic urinary bladder toxicity evaluation of N‐Nitrosodiphenylamine in Fischer 344 rats (2013) (5)
Identifying genes that mediate anthracyline toxicity in immune cells (2015) (5)
Implementing in vitro bioactivity data to modernize priority setting of chemical inventories. (2021) (5)
Response to “Incorporating Biological, Chemical, and Toxicological Knowledge Into Predictive Models of Toxicity” (2012) (4)
Basal Gene Expression in Male and Female Sprague-Dawley Rat Nasal Respiratory and Olfactory Epithelium (2007) (4)
Correction to Screening Chemicals for Estrogen Receptor Bioactivity Using a Computational Model. (2017) (4)
Estimating Hepatotoxic Doses Using High-Content Imaging in Primary Hepatocytes. (2021) (4)
Subchronic Thyroid Toxicity Evaluation of 4,4′-Methylenebis(N,N′-Dimethyl)Aniline in Fischer 344 Rats (2012) (4)
A Framework that Considers the Impacts of Time, Cost, and Uncertainty in the Determination of the Cost Effectiveness of Toxicity‐Testing Methodologies (2021) (3)
Subchronic Hepatotoxicity Evaluation of 2,3,4,6-Tetrachlorophenol in Sprague Dawley Rats (2012) (3)
Batch Profile Estimation, Correction, and Scoring (2009) (2)
A Chemical Category-Based Approach for Selecting and Screening PFAS for Toxicity and Toxicokinetic Testing (2019) (2)
Chapter 5:Transcriptomic Dose–Response Analysis for Mode of Action and Risk Assessment (2016) (2)
Biologically Motivated Approaches to Extrapolation from High to Low Doses and the Advent of Systems Biology: The Road to Toxicological Safety Assessment (2007) (2)
A value of information framework for assessing the trade-offs associated with uncertainty, duration, and cost of chemical toxicity testing. (2022) (2)
IVT-seq reveals extreme bias in RNA-sequencing (2014) (2)
Incorporating Human Dosimetry and Exposure Information with High–Throughput Screening Data in Chemical Toxicity Assessment (2013) (2)
Chemical Screening in an Estrogen Receptor Transactivation Assay with Metabolic Competence. (2022) (2)
Corrigendum to: "Profiling the ToxCast Library With a Pluripotent Human (H9) Stem Cell Line-Based Biomarker Assay for Developmental Toxicity". (2020) (1)
Analysis of Transcriptomic Dose–Response Data for Toxicology and Risk Assessment (2011) (1)
Towards reproducible structure-based chemical categories for PFAS to inform and evaluate toxicity and toxicokinetic testing (2022) (1)
Subchronic Toxicity Evaluation of Anthraquinone in Fischer 344 Rats (2013) (1)
QSAR Modeling of Caco-2 Permeability for the Estimation of Oral Bioavailability (2019) (1)
Application of DNA microarrays for predicting toxicity and evaluating cross-species extrapolation (2003) (1)
Evolution of computational toxicology: From primitive beginnings to sophisticated application (2016) (1)
LETTER TO EDITOR Response to "Accurate Risk-Based Chemical Screening Relies on Robust Exposure Estimates" (2012) (0)
EPA’s Path Towards More Rapid, Efficient, and Protective Chemical Testing with Fewer Animals (2020) (0)
Assessing Safety without Animal Testing: The Road Ahead. (2022) (0)
Retrofitting an Estrogen Receptor Transactivation Assay with Metabolic Competence Using Alginate Immobilization of Metabolic Enzymes (AIME) (2018) (0)
Expression of Cyp4a10 and Pdk4 genes in the livers of mice exposed to reference compound activators of CAR, FXR, Nrf2, PPARα, and PXR. (2015) (0)
Supplementary File 8 (2010) (0)
Retrospective and Prospective Case Studies to Accelerate the Pace of Chemical Risk Assessment (2019) (0)
Supplementary File 9 (2010) (0)
Microarrays: Use in Gene Identification (2006) (0)
Genomic dose-response modeling to inform key events in mode-of-action risk assessment (2012) (0)
Positive Surgical Margins in Robotic Radical Prostatectomies: Impact of Learning Curve on Oncologic Outcomes.: (2005) (0)
Renal Lesions Too Small to Classify by CT: Outcome Study Based on Follow-up for 18 to 62 Months (38 Mean) by Multiphasic Helical CT or Laparoscopy.: (2005) (0)
The Identification of Protein Kinase C Iota as a Regulator of the Mammalian Heat Shock Response Using Functional Genomic Screens (2010) (0)
SEURAT: Safety Evaluation Ultimately Replacing Animal Testing—Recommendations for future research in the field of predictive toxicology (2014) (0)
Liver-Specific mRNAs Are Present in Cell-Free Plasma in Man and May Serve as Novel Biomarkers for Drug-Induced Liver Injury (2011) (0)
Food for Thought ... The US Federal Tox 21 Program : A Strategic and Operational Plan for Continued Leadership 1 (2018) (0)
Supplementary File 12 (2010) (0)
Alginate Immobilization of Metabolic Enzymes (AIME) Coupled to an Estrogen Receptor Transactivation Assay Detects Bioactivated and Bioinactivated Estrogen Receptor Agonists (2019) (0)
Evaluating NAMs for Toxicokinetics (2018) (0)
Recommended approaches in the application of toxicogenomics to derive points of departure for chemical risk assessment (2016) (0)
Supplementary File 10 (2010) (0)
Coming to Terms with the State of the Science in Environmental Toxicology and Defining a Path for the Future (2019) (0)
Overview of NCCT Activities in the Chemical Safety for Sustainability National Program (2018) (0)
Assessment of Chemicals, Using and Developing New Approach Methodologies (NAMs) (2018) (0)
Assessing Bioactivity-Exposure Profiles of Fruits and Vegetables in the BioMAP Profiling System (2019) (0)
Looking Back to Go Forward in Toxicology and Chemical Risk Assessment (2019) (0)
Risk Assessment Approaches for Chlorine and Other Respiratory Tract Irritant Gases (2010) (0)
New Approach Methodologies in TSCA Implementation: Perspectives from EPA ORD (2020) (0)
Supplementary File 14 (2010) (0)
Supplementary file 7. (2010) (0)

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What Schools Are Affiliated With Russell S. Thomas?

Russell S. Thomas is affiliated with the following schools:

University of Wisconsin–Madison
University of Chicago
Colorado State University
Tabor College