Ryoichiro Kageyama

Ryoichiro Kageyama's AcademicInfluence.com Rankings

Ryoichiro Kageyama

Physics

#4700

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#6415

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physics Degrees

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Physics

Ryoichiro Kageyama's Degrees

PhD Physics University of Tokyo
Masters Physics University of Tokyo
Bachelors Physics University of Tokyo

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Ryoichiro Kageyama's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Control of endodermal endocrine development by Hes-1 (2000) (1190)
Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain (2008) (1002)
Hes1 and Hes5 as Notch effectors in mammalian neuronal differentiation (1999) (838)
Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects. (1995) (747)
Oscillatory Expression of the bHLH Factor Hes1 Regulated by a Negative Feedback Loop (2002) (731)
Cloning and expression of cDNA for a human thromboxane A2 receptor (1991) (663)
The Hes gene family: repressors and oscillators that orchestrate embryogenesis (2007) (624)
Essential Roles of Notch Signaling in Maintenance of Neural Stem Cells in Developing and Adult Brains (2010) (622)
Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split. (1992) (618)
Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation (2004) (579)
Oscillations in Notch Signaling Regulate Maintenance of Neural Progenitors (2008) (549)
Roles of bHLH genes in neural stem cell differentiation. (2005) (507)
Potential for neural regeneration after neurotoxic injury in the adult mammalian retina. (2004) (440)
Oscillatory Control of Factors Determining Multipotency and Fate in Mouse Neural Progenitors (2013) (429)
Persistent expression of helix‐loop‐helix factor HES‐1 prevents mammalian neural differentiation in the central nervous system. (1994) (418)
Roles of the Basic Helix-Loop-Helix Genes Hes1 and Hes5 in Expansion of Neural Stem Cells of the Developing Brain* (2001) (411)
BMP2-mediated alteration in the developmental pathway of fetal mouse brain cells from neurogenesis to astrocytogenesis (2001) (390)
Basic helix-loop-helix transcription factors regulate the neuroendocrine differentiation of fetal mouse pulmonary epithelium. (2000) (388)
Helix-loop-helix factors in growth and differentiation of the vertebrate nervous system. (1997) (376)
A Mammalian Helix-Loop-Helix Factor Structurally Related to the Product of Drosophila Proneural Gene atonal Is a Positive Transcriptional Regulator Expressed in the Developing Nervous System(*) (1995) (355)
Dynamic expression and essential functions of Hes7 in somite segmentation. (2001) (354)
Mammalian hairy and Enhancer of Split Homolog 1 Regulates Differentiation of Retinal Neurons and Is Essential for Eye Morphogenesis (1996) (349)
Dynamic Notch signaling in neural progenitor cells and a revised view of lateral inhibition (2008) (319)
Real-time imaging of the somite segmentation clock: Revelation of unstable oscillators in the individual presomitic mesoderm cells (2006) (315)
Mammalian achaete–scute and atonal homologs regulate neuronal versus glial fate determination in the central nervous system (2000) (313)
Structure, chromosomal locus, and promoter analysis of the gene encoding the mouse helix-loop-helix factor HES-1. Negative autoregulation through the multiple N box elements. (1994) (310)
Molecular characterization of a rat negative regulator with a basic helix-loop-helix structure predominantly expressed in the developing nervous system. (1992) (309)
The Notch-Hes pathway in mammalian neural development (1999) (302)
Hes1 and Hes5 Activities Are Required for the Normal Development of the Hair Cells in the Mammalian Inner Ear (2001) (298)
Dclk1 distinguishes between tumor and normal stem cells in the intestine (2012) (293)
Roles of Hes genes in neural development (2008) (287)
Periodic repression by the bHLH factor Hes7 is an essential mechanism for the somite segmentation clock. (2003) (274)
Mouse Fbw7/Sel-10/Cdc4 Is Required for Notch Degradation during Vascular Development* (2004) (273)
Hes1 is a negative regulator of inner ear hair cell differentiation. (2000) (273)
The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation. (2000) (269)
Retinal cell fate determination and bHLH factors. (2004) (265)
The bHLH Gene Hes1 as a Repressor of the Neuronal Commitment of CNS Stem Cells (2000) (264)
Glial cell fate specification modulated by the bHLH gene Hes5 in mouse retina. (2000) (263)
Roles of homeobox and bHLH genes in specification of a retinal cell type. (2001) (263)
Topological defects control collective dynamics in neural progenitor cell cultures (2017) (254)
The cyclic gene Hes1 contributes to diverse differentiation responses of embryonic stem cells. (2009) (244)
The bHLH gene Hes1 is essential for expansion of early T cell precursors. (1999) (239)
Integrated regulation of Toll-like receptor responses by Notch and interferon-gamma pathways. (2008) (238)
Math3 and NeuroD regulate amacrine cell fate specification in the retina. (2002) (236)
Instability of Hes7 protein is crucial for the somite segmentation clock (2004) (236)
The role of notch signaling in the development of intrahepatic bile ducts. (2004) (234)
Molecular cloning and characterization of a human DNA binding factor that represses transcription (1989) (234)
Candidate markers for stem and early progenitor cells, Musashi‐1 and Hes1, are expressed in crypt base columnar cells of mouse small intestine (2003) (233)
Notch signaling via Hes1 transcription factor maintains survival of melanoblasts and melanocyte stem cells (2006) (233)
Conversion of biliary system to pancreatic tissue in Hes1-deficient mice (2004) (232)
Hes genes regulate sequential stages of neurogenesis in the olfactory epithelium. (2000) (231)
bHLH Factors in Self-Renewal, Multipotency, and Fate Choice of Neural Progenitor Cells (2014) (230)
Target Selectivity of Vertebrate Notch Proteins (2006) (229)
Cloning and sequence analysis of cDNA for human renin precursor. (1983) (225)
Cloning and sequence analysis of cDNA for rat angiotensinogen. (1983) (219)
Persistent and high levels of Hes1 expression regulate boundary formation in the developing central nervous system (2006) (216)
Hes1 Directly Controls Cell Proliferation through the Transcriptional Repression of p27Kip1 (2005) (207)
Defective Brain Development in Mice Lacking the Hif-1α Gene in Neural Cells (2003) (207)
Hes genes and neurogenin regulate non-neural versus neural fate specification in the dorsal telencephalic midline (2008) (201)
Id sustains Hes1 expression to inhibit precocious neurogenesis by releasing negative autoregulation of Hes1. (2007) (201)
bHLH transcription factors and mammalian neuronal differentiation. (1997) (198)
Regulation of retinal cell fate specification by multiple transcription factors (2008) (195)
Hes7: a bHLH‐type repressor gene regulated by Notch and expressed in the presomitic mesoderm (2001) (189)
Progenitor cell proliferation in the retina is dependent on Notch-independent Sonic hedgehog/Hes1 activity (2009) (185)
A Mechanism for Gene-Environment Interaction in the Etiology of Congenital Scoliosis (2012) (183)
Sustained Notch signaling in progenitors is required for sequential emergence of distinct cell lineages during organogenesis. (2006) (183)
The initiation and propagation of Hes7 oscillation are cooperatively regulated by Fgf and notch signaling in the somite segmentation clock. (2007) (182)
Temporal regulation of Cre recombinase activity in neural stem cells (2006) (181)
Continuous neurogenesis in the adult forebrain is required for innate olfactory responses (2011) (179)
High Levels of Cre Expression in Neuronal Progenitors Cause Defects in Brain Development Leading to Microencephaly and Hydrocephaly (2006) (170)
Otx2 Regulates Subtype Specification and Neurogenesis in the Midbrain (2005) (165)
Induction of photoreceptor-specific phenotypes in adult mammalian iris tissue (2001) (163)
Conversion of ectoderm into a neural fate by ATH‐3, a vertebrate basic helix–loop–helix gene homologous to Drosophila proneural gene atonal (1997) (159)
HES-1 preserves purified hematopoietic stem cells ex vivo and accumulates side population cells in vivo. (2003) (159)
Intronic delay is essential for oscillatory expression in the segmentation clock (2011) (159)
The Basic Helix-Loop-Helix Genes Hesr1/Hey1 and Hesr2/Hey2 Regulate Maintenance of Neural Precursor Cells in the Brain* (2003) (159)
Mash1 promotes neuronal differentiation in the retina (1996) (159)
Accelerating the tempo of the segmentation clock by reducing the number of introns in the Hes7 gene. (2013) (155)
The bHLH Gene Hes1 Regulates Differentiation of Multiple Cell Types (2000) (152)
Hes1 and Hes3 regulate maintenance of the isthmic organizer and development of the mid/hindbrain (2001) (152)
Ectopic pancreas formation in Hes1 -knockout mice reveals plasticity of endodermal progenitors of the gut, bile duct, and pancreas. (2006) (149)
Nuclear factor ETF specifically stimulates transcription from promoters without a TATA box. (1989) (145)
Requirement of Multiple Basic Helix-Loop-Helix Genes for Retinal Neuronal Subtype Specification* (2004) (144)
Primary structure of human preangiotensinogen deduced from the cloned cDNA sequence. (1984) (143)
Dynamic regulation of Notch signaling in neural progenitor cells. (2009) (141)
Ultradian oscillations of Stat, Smad, and Hes1 expression in response to serum (2007) (139)
Notch-Hes1 pathway is required for the development of IL-17-producing γδ T cells. (2011) (130)
Structure, chromosomal locus, and promoter of mouse Hes2 gene, a homologue of Drosophila hairy and Enhancer of split. (1998) (129)
Essential roles of the histone methyltransferase ESET in the epigenetic control of neural progenitor cells during development (2011) (126)
Defective brain development in mice lacking the Hif-1alpha gene in neural cells. (2003) (126)
Oscillations in notch signaling regulate maintenance of neural progenitors (2008) (125)
The role of Hes genes in intestinal development, homeostasis and tumor formation (2012) (122)
FGF induces oscillations of Hes1 expression and Ras/ERK activation (2008) (122)
Role of Toxoplasma gondii myosin A in powering parasite gliding and host cell invasion (2017) (120)
Prdm Proto-Oncogene Transcription Factor Family Expression and Interaction with the Notch-Hes Pathway in Mouse Neurogenesis (2008) (119)
Hes repressors are essential regulators of hematopoietic stem cell development downstream of Notch signaling (2013) (117)
Dynamic Expression of Notch Signaling Genes in Neural Stem/Progenitor Cells (2011) (116)
Oscillatory control of Delta-like1 in cell interactions regulates dynamic gene expression and tissue morphogenesis (2016) (115)
Visualization of embryonic neural stem cells using Hes promoters in transgenic mice (2006) (115)
MATH-2, a mammalian helix-loop-helix factor structurally related to the product of Drosophila proneural gene atonal, is specifically expressed in the nervous system. (1995) (114)
The Basic Helix-Loop-Helix Gene hesr2 Promotes Gliogenesis in Mouse Retina (2001) (113)
Epidermal growth factor (EGF) receptor gene transcription. Requirement for Sp1 and an EGF receptor-specific factor. (1988) (111)
Structure and Promoter Analysis of the Gene Encoding the Mouse Helix-Loop-Helix Factor HES-5 (1995) (110)
Species-specific segmentation clock periods are due to differential biochemical reaction speeds (2020) (109)
MicroRNA9 regulates neural stem cell differentiation by controlling Hes1 expression dynamics in the developing brain (2012) (109)
In vitro characterization of the human segmentation clock (2018) (108)
Fbxw7-dependent Degradation of Notch Is Required for Control of “Stemness” and Neuronal-Glial Differentiation in Neural Stem Cells* (2011) (106)
Six1 is essential for early neurogenesis in the development of olfactory epithelium. (2007) (105)
Ectopic expression of the bHLH gene Math1 disturbs neural development (1999) (104)
Fate of neural stem cells grafted into injured inner ears of mice (2003) (103)
The Role of Notch Signaling in Adult Neurogenesis (2011) (103)
Continuous Postnatal Neurogenesis Contributes to Formation of the Olfactory Bulb Neural Circuits and Flexible Olfactory Associative Learning (2014) (100)
Regulation of mammalian neural development by helix-loop-helix transcription factors. (1995) (94)
Different types of oscillations in Notch and Fgf signaling regulate the spatiotemporal periodicity of somitogenesis. (2011) (93)
Continuous neurogenesis in the adult brain (2009) (90)
Molecular characterization of transcription factors that bind to the cAMP responsive region of the substance P precursor gene. cDNA cloning of a novel C/EBP-related factor. (1991) (90)
High Hes1 expression and resultant Ascl1 suppression regulate quiescent vs. active neural stem cells in the adult mouse brain (2019) (89)
Hes1 and Hes5 control the progenitor pool, intermediate lobe specification, and posterior lobe formation in the pituitary development. (2007) (89)
CCAAT/Enhancer-Binding Protein Phosphorylation Biases Cortical Precursors to Generate Neurons Rather Than Astrocytes In Vivo (2005) (88)
Oscillations, clocks and segmentation. (2003) (86)
Cooperative functions of Hes/Hey genes in auditory hair cell and supporting cell development. (2011) (85)
Hes1 regulates embryonic stem cell differentiation by suppressing Notch signaling (2010) (82)
A transcription factor active on the epidermal growth factor receptor gene. (1988) (82)
Molecular characterization of HES-2, a mammalian helix-loop-helix factor structurally related to Drosophila hairy and Enhancer of split. (1993) (81)
Cadherin-based adhesions in the apical endfoot are required for active Notch signaling to control neurogenesis in vertebrates (2014) (81)
The functional significance of newly born neurons integrated into olfactory bulb circuits (2014) (80)
Induction of rat liver angiotensinogen mRNA following acute inflammation. (1985) (78)
Prethymic T‐cell development defined by the expression of paired immunoglobulin‐like receptors (2005) (77)
Maximizing Functional Photoreceptor Differentiation From Adult Human Retinal Stem Cells (2009) (77)
Generation of Structurally and Functionally Distinct Factors from the Basic Helix-Loop-Helix Gene Hes3 by Alternative First Exons* (2000) (76)
dlk Inhibits Stem Cell Factor‐Induced Colony Formation of Murine Hematopoietic Progenitors: Hes‐1‐Independent Effect (2001) (76)
Expression dynamics and functions of Hes factors in development and diseases. (2014) (75)
Oscillator mechanism of notch pathway in the segmentation clock (2007) (74)
Mind bomb 1 is required for pancreatic β-cell formation (2012) (73)
Transcription factor Hes1 modulates osteoarthritis development in cooperation with calcium/calmodulin-dependent protein kinase 2 (2015) (72)
Contents (2013) (71)
Differential expression of the multiple forms of rat prekininogen mRNAs after acute inflammation. (1985) (71)
Identification of a Novel Basic Helix-Loop-Helix Gene, Heslike, and Its Role in GABAergic Neurogenesis (2004) (70)
Otx2 homeobox gene induces photoreceptor-specific phenotypes in cells derived from adult iris and ciliary tissue. (2004) (70)
Ultradian oscillations and pulses: coordinating cellular responses and cell fate decisions (2014) (70)
Six1 is indispensable for production of functional progenitor cells during olfactory epithelial development. (2010) (69)
Notch1 expression is spatiotemporally correlated with neurogenesis and negatively regulated by Notch1-independent Hes genes in the developing nervous system. (2006) (69)
Hes5 regulates the transition timing of neurogenesis and gliogenesis in mammalian neocortical development (2017) (68)
Dynamic control of neural stem cells by bHLH factors (2019) (66)
Zinc finger genes Fezf1 and Fezf2 control neuronal differentiation by repressing Hes5 expression in the forebrain (2010) (66)
Roles of the bHLH gene Hes1 in retinal morphogenesis (2004) (63)
Oscillatory gene expression and somitogenesis (2012) (63)
Coupling delay controls synchronized oscillation in the segmentation clock (2020) (62)
Genetic Methods to Identify and Manipulate Newly Born Neurons in the Adult Brain (2011) (61)
Sustained mobilization of endogenous neural progenitors delays disease progression in a transgenic model of Huntington's disease. (2013) (61)
Hedgehog signaling regulates prosensory cell properties during the basal-to-apical wave of hair cell differentiation in the mammalian cochlea (2013) (60)
Hes1 and Hes5 Regulate the Development of the Cranial and Spinal Nerve Systems (2006) (59)
Notch‐Hes1 pathway contributes to the cochlear prosensory formation potentially through the transcriptional down‐regulation of p27Kip1 (2009) (57)
The Parkinson’s Disease-Associated Protein Kinase LRRK2 Modulates Notch Signaling through the Endosomal Pathway (2015) (55)
Gene Expression Profiling of Neural Stem Cells and Identification of Regulators of Neural Differentiation During Cortical Development (2011) (55)
Notch and HES5 are regulated during human cartilage differentiation (2007) (55)
Math6, a bHLH gene expressed in the developing nervous system, regulates neuronal versus glial differentiation (2001) (54)
Hes1-deficient mice show precocious differentiation of Paneth cells in the small intestine. (2005) (54)
Iris-derived cells from adult rodents and primates adopt photoreceptor-specific phenotypes. (2005) (53)
Oscillatory control of bHLH factors in neural progenitors (2014) (53)
Ultradian oscillations in Notch signaling regulate dynamic biological events. (2010) (53)
Retrovirus-mediated gene transfer to retinal explants. (2002) (52)
Enhanced lysosomal degradation maintains the quiescent state of neural stem cells (2019) (51)
Mash1 and Math3 Are Required for Development of Branchiomotor Neurons and Maintenance of Neural Progenitors (2005) (51)
Dynamic expression and roles of Hes factors in neural development (2014) (50)
Genetic visualization of notch signaling in mammalian neurogenesis (2012) (49)
Hes1 Regulates Corneal Development and the Function of Corneal Epithelial Stem/Progenitor Cells (2008) (49)
Developing HSCs become Notch independent by the end of maturation in the AGM region. (2016) (48)
Oscillations of MyoD and Hes1 proteins regulate the maintenance of activated muscle stem cells (2019) (44)
Regulation of active and quiescent somatic stem cells by Notch signaling (2019) (43)
Deubiquitinating enzymes regulate Hes1 stability and neuronal differentiation (2015) (42)
The role of neurogenesis in olfaction-dependent behaviors (2012) (42)
Epidermal growth factor (EGF) receptor gene transcription (1988) (41)
Oscillatory control of Delta-like1 in somitogenesis and neurogenesis: A unified model for different oscillatory dynamics. (2016) (41)
ES cell-derived presomitic mesoderm-like tissues for analysis of synchronized oscillations in the segmentation clock (2018) (39)
Optogenetic perturbation and bioluminescence imaging to analyze cell-to-cell transfer of oscillatory information. (2017) (39)
Therapeutic targeting of HES1 transcriptional programs in T-ALL. (2015) (37)
Hes1 Oscillations Contribute to Heterogeneous Differentiation Responses in Embryonic Stem Cells (2011) (37)
Hes1 suppresses acute myeloid leukemia development through FLT3 repression (2014) (36)
The roles and mechanism of ultradian oscillatory expression of the mouse Hes genes. (2014) (33)
Significance of proneural basic helix-loop-helix transcription factors in neuroendocrine differentiation of fetal lung epithelial cells and lung carcinoma cells. (2001) (32)
Hbp1 regulates the timing of neuronal differentiation during cortical development by controlling cell cycle progression (2015) (31)
A multifunctional teal-fluorescent Rosa26 reporter mouse line for Cre- and Flp-mediated recombination (2012) (31)
Retinoid Acid Specifies Neuronal Identity through Graded Expression of Ascl1 (2013) (31)
Notch1 mediates visfatin-induced FGF-2 up-regulation and endothelial angiogenesis. (2011) (31)
Hes1 in the somatic cells of the murine ovary is necessary for oocyte survival and maturation. (2013) (31)
Helix-loop-helix-type transcription factor (HES-1) is expressed in osteoblastic cells, suppressed by 1,25(OH)2 vitamin D3, and modulates 1,25(OH)2 vitamin D3 enhancement of osteopontin gene expression. (1997) (30)
Hyperpolarisation‐activated cyclic nucleotide‐gated channels regulate the spontaneous firing rate of olfactory receptor neurons and affect glomerular formation in mice (2013) (30)
Complementary DNA sequences of renin. State-of-the-art review. (1984) (28)
Mutation of HES7 in a large extended family with spondylocostal dysostosis and dextrocardia with situs inversus (2013) (28)
Expression and chromosomal localization of the gene for the human transcriptional repressor GCF. (1992) (27)
Mash1 is required for neuroendocrine cell development in the glandular stomach (2007) (27)
Three-dimensional live imaging of Atoh1 reveals the dynamics of hair cell induction and organization in the developing cochlea (2019) (27)
Impact of Sox9 Dosage and Hes1-mediated Notch Signaling in Controlling the Plasticity of Adult Pancreatic Duct Cells in Mice (2015) (26)
Control of Hes7 Expression by Tbx6, the Wnt Pathway and the Chemical Gsk3 Inhibitor LiCl in the Mouse Segmentation Clock (2013) (26)
Jag1 Modulates an Oscillatory Dll1-Notch-Hes1 Signaling Module to Coordinate Growth and Fate of Pancreatic Progenitors. (2020) (26)
Regulation of temporal properties of neural stem cells and transition timing of neurogenesis and gliogenesis during mammalian neocortical development. (2019) (25)
Oscillatory Control of Notch Signaling in Development. (2018) (24)
Structure and chromosomal locus of the mouse gene encoding a cerebellar Purkinje cell-specific helix-loop-helix factor Hes-3. (1994) (23)
Rhythmic gene expression in somite formation and neural development (2009) (23)
Regulated expression of neurogenic basic helix-loop-helix transcription factors during differentiation of the immortalized neuronal progenitor cell line HC2S2 into neurons (1998) (23)
The first Hes1 dimer inhibitors from natural products. (2009) (23)
Hes1 plays an essential role in Kras-driven pancreatic tumorigenesis (2019) (22)
Disappearance of centroacinar cells in the Notch ligand‐deficient pancreas (2015) (22)
Differing utilization of homologous transcription initiation sites of rat K and T kininogen genes under inflammation condition. (1987) (21)
Structure and promoter analysis of Math3 gene, a mouse homolog of Drosophila proneural gene atonal. Neural-specific expression by dual promoter elements. (1998) (21)
Hes1 oscillation: Making variable choices for stem cell differentiation (2010) (20)
Fgf4 maintains Hes7 levels critical for normal somite segmentation clock function (2020) (20)
Simultaneous Requirements for Hes1 in Retinal Neurogenesis and Optic Cup–Stalk Boundary Maintenance (2020) (20)
Dynamic Advances in NF-κB Signaling Analysis (2009) (19)
ATP and spontaneous calcium oscillations control neural stem cell fate determination in Huntington’s disease: a novel approach for cell clock research (2020) (18)
Small-molecule screening yields a compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone (2018) (18)
Oscillations of Delta-like1 regulate the balance between differentiation and maintenance of muscle stem cells (2021) (18)
Oscillatory links of Fgf signaling and Hes7 in the segmentation clock. (2013) (17)
Fbxw 7-dependent degradation of Notch is required for control of stemness and neuronal-glial differentiation in neural stem cells (2011) (17)
Oscillatory expression of Hes1 regulates cell proliferation and neuronal differentiation in the embryonic brain (2020) (17)
The ALK-1/SMAD/ATOH8 axis attenuates hypoxic responses and protects against the development of pulmonary arterial hypertension (2019) (17)
Transcriptional Regulation of Mouse Type 1 Inositol 1,4,5‐Trisphosphate Receptor Gene by NeuroD‐Related Factor (1999) (16)
BMP-induced Atoh8 attenuates osteoclastogenesis by suppressing Runx2 transcriptional activity and reducing the Rankl/Opg expression ratio in osteoblasts (2020) (16)
Jag1 modulates an oscillatory Dll1-Notch-Hes1 signaling module to coordinate growth and fate of pancreatic progenitors (2018) (16)
Hes1 and Hes5 are required for differentiation of pituicytes and formation of the neurohypophysis in pituitary development (2015) (15)
Multilayered gene control drives timely exit from the stem cell state in uncommitted progenitors during Drosophila asymmetric neural stem cell division (2018) (15)
Real-time imaging of bHLH transcription factors reveals their dynamic control in the multipotency and fate choice of neural stem cells (2015) (14)
Amygdala kindling induces nestin expression in the leptomeninges of the neocortex (2013) (13)
Spatiotemporal pattern in somitogenesis: a non-Turing scenario with wave propagation. (2009) (13)
HES1 and HES5 Are Dispensable for Cartilage and Endochondral Bone Formation (2010) (13)
Hes1 overexpression leads to expansion of embryonic neural stem cell pool and stem cell reservoir in the postnatal brain (2021) (12)
Methylation deficiency disrupts biological rhythms from bacteria to humans (2020) (12)
Expression and regulation of the gene for arginase I in mouse salivary glands: requirement of CCAAT/enhancer-binding protein alpha for the expression in the parotid gland. (2002) (12)
Roles of Hes bHLH Factors in Neural Development (2006) (11)
Ultradian oscillators in somite segmentation and other biological events. (2007) (11)
Generation of a MOR‐CreER knock‐in mouse line to study cells and neural circuits involved in mu opioid receptor signaling (2020) (11)
A novel cis-acting element regulates HES-1 gene expression in P19 embryonal carcinoma cells treated with retinoic acid. (2000) (11)
Cell cycle arrest determines adult neural stem cell ontogeny by an embryonic Notch-nonoscillatory Hey1 module (2021) (10)
Use of cell type‐specific transcriptome to identify genes specifically involved in Müller glia differentiation during retinal development (2014) (10)
Reconstitution of an Ultradian Oscillator in Mammalian Cells by a Synthetic Biology Approach. (2018) (10)
Goosecoid suppresses cell growth and enhances neuronal differentiation of PC12 cells. (2000) (10)
In vivo overactivation of the Notch signaling pathway in the developing cochlear epithelium (2015) (10)
Oscillatory expression of Hes1 regulates cell proliferation and neuronal differentiation in the embryonic brain. (2020) (10)
Lysosomes and signaling pathways for maintenance of quiescence in adult neural stem cells (2020) (10)
Light-induced silencing of neural activity in Rosa26 knock-in mice conditionally expressing the microbial halorhodopsin eNpHR2.0 (2013) (10)
Angiotensinogen and kininogen: cloning and sequence analysis of the cDNAs. (1983) (9)
Species-specific oscillation periods of human and mouse segmentation clocks are due to cell autonomous differences in biochemical reaction parameters (2019) (9)
The proneural bHLH genes Mash1, Math3 and NeuroD are required for pituitary development. (2018) (9)
The significance of gene expression dynamics in neural stem cell regulation (2020) (9)
Overexpression of RFT induces G1-S arrest and apoptosis via p53/p21(Waf1) pathway in glioma cell. (2004) (9)
Making Waves toward the Shore by Synchronicity. (2016) (9)
Automatic reconstruction of the mouse segmentation network from an experimental evidence database (2010) (8)
Notch–Hes signaling in pituitary development (2008) (8)
Retroviral vectors for gene delivery to neural precursor cells. (2003) (8)
Dynamic Notch Signaling in Neural Progenitor Cells (2013) (7)
Visualization of Notch signaling oscillation in cells and tissues. (2014) (7)
Genetic mapping of four mouse bHLH genes related to Drosophila proneural gene atonal. (1996) (7)
Hes1 expression in mature neurons in the adult mouse brain is required for normal behaviors (2019) (7)
Sonic hedgehog expands neural stem cells in the neocortical region leading to an expanded and wrinkled neocortical surface (2021) (7)
Structure and Promoter Analysis of Math3 Gene, a Mouse Homolog of Drosophila Proneural Geneatonal (1998) (7)
Hopf bifurcation in the presomitic mesoderm during the mouse segmentation. (2009) (6)
In vivo evaluation of PhiC31 recombinase activity in transgenic mice (2012) (6)
Hes1 Is Essential in Proliferating Ductal Cell–Mediated Development of Intrahepatic Cholangiocarcinoma (2020) (6)
Therapeutic targeting of HES 1 transcriptional programs in TALL (2015) (5)
Requirement of multiple lysine residues for the transcriptional activity and the instability of Hes7. (2008) (5)
Topological defect launches 3D mound in the active nematic sheet of neural progenitors (2016) (5)
Practical Lessons from Theoretical Models about the Somitogenesis (2007) (4)
In vitro characterization of the human segmentation clock (2020) (4)
Novel Roles of Small Extracellular Vesicles in Regulating the Quiescence and Proliferation of Neural Stem Cells (2021) (4)
Virus Vectors for use in the Central Nervous System (2003) (4)
Functional rejuvenation of aged neural stem cells by Plagl2 and anti-Dyrk1a activity (2021) (4)
The Basic Helix-Loop-Helix Transcription Factors in Neural Differentiation (2010) (4)
Six1 is indispensable for production of functional apical and basal progenitors during olfactory epithelial development (2010) (4)
Fgf4 is critical for maintaining Hes7 levels and Notch oscillations in the somite segmentation clock (2020) (4)
Hbp1 regulates the timing of neuronal differentiation during cortical development by controlling cell cycle progression (2015) (3)
The proneural bHLH genes Mash1, Math3 and NeuroD are required for pituitary development (2018) (3)
Dual activation of Shh and Notch signaling induces dramatic enlargement of neocortical surface area (2021) (3)
BMP-induced Atoh8 attenuates osteoclastogenesis by suppressing Runx2 transcriptional activity and reducing the Rankl/Opg expression ratio in osteoblasts. (2020) (3)
Segmentation Genes Enter an Excited State. (2017) (3)
Author Correction: Oscillations of Delta-like1 regulate the balance between differentiation and maintenance of muscle stem cells (2021) (3)
Oscillatory expression of Ascl1 in oligodendrogenesis. (2021) (3)
Id genes are required for morphogenesis and cellular patterning in the developing mammalian cochlea. (2019) (3)
Hes1 oscillation frequency correlates with activation of neural stem cells. (2021) (3)
Illuminating information transfer in signaling dynamics by optogenetics. (2017) (2)
Essential role of Notch/Hes1 signaling in postnatal pancreatic exocrine development (2021) (2)
CLOCK/BMAL1 interferes with segmentation clock oscillation in mouse embryonic organoids (2020) (2)
Circadian key component CLOCK/BMAL1 interferes with segmentation clock in mouse embryonic organoids (2020) (2)
Control of kininogen gene expression. (1989) (2)
Gene delivery to the nervous system by direct injection of retroviral vector (1995) (2)
Modification of gene expression and soluble factor secretion in the lateral ventricle choroid plexus: Analysis of the impacts on the neocortical development (2021) (2)
[Regulation of neuronal differentiation by bHLH factors]. (2000) (2)
Helix-loop-helix (bHLH) proteins: Hes family (2009) (2)
Ultradian Oscillation Networks in Somite Segmentation and Other Biological Events (2009) (2)
Roles of notch signaling in adult neural stem cells (2010) (2)
Continuous neurogenesis in the adult forebrain is required for gender-specific activities (2011) (2)
Light-induced silencing of neural activity in Rosa26 knock-in and BAC transgenic mice conditionally expressing the microbial halorhodopsin eNpHR3 (2020) (1)
In vitro transcription of epidermal growth factor receptor gene. (1991) (1)
High Hes1 expression and resultant Ascl1 suppression regulate quiescent versus active neural stem cells in the adult mouse brain (2019) (1)
Id proteins sustain Hes1 expression to maintain neural stem cells (2008) (1)
The significance and mechanism of adult neurogenesis (2009) (1)
Roles of bHLH genes in neural development (2006) (1)
Dynamic Delta-like1 expression in presomitic mesoderm cells during somite segmentation. (2019) (1)
Biological significance of the coupling delay in synchronized oscillations. (2022) (1)
Maintenance of Neural Stem Cells in the Brain: Role of Notch Signaling (2012) (1)
Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis. (2019) (1)
A spinal synergy of excitatory and inhibitory neurons coordinates ipsilateral body movements (2023) (1)
[Transcription factor network that regulates neural development]. (2008) (1)
The cyclic gene Hes1 contributes to diverse differentiation responses of mouse embryonic stem (ES) cells by regulating Notch signaling activation (2010) (1)
Roles of Hes genes in development of cerebral cortex and choroid plexus (2006) (1)
Hesl is required for the development of intrahepatic bile ducts (2003) (1)
Publisher Correction: Methylation deficiency disrupts biological rhythms from bacteria to humans (2020) (1)
An Optogenetic Method to Control and Analyze Gene Expression Patterns in Cell-to-cell Interactions. (2018) (1)
[Regulation of neural differentiation by HES helix-loop-helix transcription factors]. (1995) (1)
Analysis of basic helix-loop-helix transcription factors mRNA in the developing mouse lungs. (1999) (0)
Jag1 coordinates release from multipotency with cell fate choice in the developing pancreas (2019) (0)
[Regulation of neural development by the bHLH factor Hes1]. (2008) (0)
Methylation deficiency disrupts biological rhythms from bacteria to humans (2020) (0)
Coupling delay controls synchronized oscillation in the segmentation clock (2020) (0)
[Regulatory mechanisms and transcription factors for cell differentiation and body morphogenesis]. (2000) (0)
Six1 is a key regulator of multiple cell type differentiation in olfactory epithelium (2006) (0)
Requirement of continuous neurogenesis for the structural and functional integrity of the adult brain (2008) (0)
[Mechanisms for maintenance and differentiation of neural stem cells]. (2004) (0)
Title Ultradian oscillations and pulses : coordinating cellularresponses and cell fate decisions (2019) (0)
250 : Selective regulation of cytokine and chemokine expression by the Notch pathway (2013) (0)
Notch signaling dynamics during murine morphogenesis (2016) (0)
Optogenetic control of neural stem cells (2018) (0)
DEPARTMENT OF CELL BIOLOGY LABORATORY OF GROWTH REGULATION The research interest of this laboratory is to understand the molecular mechanism of cell differentiation and organogenesis. Particularly, we are interested in basic helix-loop-helix (bHLH) transcription factors that regulate mammalian neura (2010) (0)
Correction: Carcagno et al., “Neurogenin3 Restricts Serotonergic Neuron Differentiation to the Hindbrain” (2015) (0)
Regulation of osteoblast differentiation by a BMP signaling-inducible gene Atoh8 (2016) (0)
Oscillatory versus persistent Hes1 expression promotes proliferation and differentiation of neural progenitors (2007) (0)
A novel role of notch pathway in region-specific induction of pancreatogenesis by regulating ptf1a expression (2006) (0)
Title The functional significance of newly born neurons integratedinto olfactory bulb circuits (2018) (0)
In vitro analysis of CNS neural precursor cells in HES-1 knockout mice (1997) (0)
Math3 and NeuroD in amacrine cell fate specification (2002) (0)
Table of Contents (1994) (0)
SS3-3 Positive and negative regulation of cytokine expression by Notch pathway (2010) (0)
Contents page + Editorial Board + Cover figure legend (2014) (0)
Requirement of Multiple bHLH Genes for Retinal Cell Fate Specification (2003) (0)
Genetic analysis of the function of helix‐loop‐helix transcription regulators in neurogenesis in the mouse (1995) (0)
Cooperative functions of Hes/Hey genes in auditory hair cell and supporting cell development (2009) (0)
GABAergic neuron production in the mouse neocortex induced by amygdala kindling (2011) (0)
Dll1 and Jag1 are Differentially Required to Specify Proximal and Distal Pancreatic Duct Compartments (2018) (0)
Increased OTX2/CRX and Decreased CHX10 Induce Optimal Photoreceptor Differentiation From Adult Human Retinal Stem Cells (2005) (0)
Hes1 Is Responsible For Notch Signaling-Mediated Suppression Of Acute Myeloid Leukemia Development Via Suppression Of FLT3 Expression (2013) (0)
Hes1 expression in mature neurons in the adult mouse brain is required for normal behaviors (2019) (0)
3P132 How To Achieve Sequential Local Folding of Epithelial Tube in Epididymis Development: Experimental and Mathematical Study(09. Development & Differentation,Poster) (2013) (0)
Title : Oscillatory control of determination factors for multipotency versus fate choice in mouse neural progenitors (2016) (0)
13-P145 Coupled oscillations in Notch and Fgf signaling underlie the coordination of the segmentation clock and the wavefront for periodic somite formation (2009) (0)
he Role of Notch Signaling in the Development of ntrahepatic Bile Ducts (2004) (0)
[Transcription factor network that regulates brain development]. (2008) (0)
Light-induced silencing of neural activity in Rosa26 knock-in and BAC transgenic mice conditionally expressing the microbial halorhodopsin eNpHR3 (2020) (0)
Correlated with Neurogenesis and Negatively Regulated by Notch1- Independent Hes Genes in the Developing Nervous System (2006) (0)
Roles of Notch-Hes signaling in adult neural stem cells (2010) (0)
The methyl cycle is a conserved regulator of biological clocks (2019) (0)
PDFlib PLOP: PDF Linearization, Optimization, Protection Page inserted by evaluation version (2001) (0)
Atoh8, a direct target gene of BMP signaling, regulates osteoblast differentiation (2015) (0)
CHAPTER 9:Light Control of Transcription in Cells (2018) (0)
Imaging and manipulating the segmentation clock (2020) (0)
[Helix-loop-helix transcription factor network regulating mammalian neurogenesis]. (1996) (0)
Induction of presomitic mesoderm-like tissue from ES cells for analysis of synchronized oscillations in the segmentation clock (2017) (0)
Potential for neural regeneration following neurotoxic injury in the adult mammalian retina (2004) (0)
Hedgehog signaling is needed for development and maintenance of the cochlear sensory epithelium (2011) (0)
Title Impact of Sox 9 Dosage and Hes 1-mediated Notch Signaling in Controlling the Plasticity of Adult Pancreatic Duct Cells in Mice (2019) (0)
Gamma-delta T cells (WS-094) Chairpersons: Yoshimasa Tanaka, Marc Bonneville (2010) (0)
GATA-2 partially rescued generation of hematopoietic cells from Jag 1 / AGM cells (2013) (0)
[Notch pathway in neural development]. (2000) (0)
The 20th IUBMB International Congress in Kyoto (2006) (0)
Two-hour cycle biological clock Hes regulates embryogenesis (2003) (0)
Genetic visualization of notch signaling in mammalian neurogenesis (2012) (0)
Collective Behavior of Cells and Topological Defects (2018) (0)
Notch-Hes1 pathway is required for the development of IL-17–producing (cid:1)(cid:2) T cells (2011) (0)
Dynamic Notch signaling in embryonic and adult neurogenesis (2010) (0)
Fork head/winged helix transcription factors, Foxa1 and Foxa2, are essential regulators of midbrain dopaminergic differentiation (2006) (0)
8 Positive and negative transcriptional regulators in mouse neurogenesis (1996) (0)
Developmental timing and oscillating gene expression (2010) (0)
Analysis Of Hes1 Function In Hedgehog Signaling During Mouse Retinal Development (2011) (0)
25 years of the segmentation clock gene (2022) (0)
Rhythmic Expression of Notch Signaling in Neural Progenitor Cells (2010) (0)
Roles of the HLH Factor HES1 in Mammalian Neural Differentiation : II. REVISITING CONGENITAL ANOMALIES WITH MOLECULAR APPROACHES : Symposia (1997) (0)
Bursting the Notch Bubble: New Insights into In Vivo Transcriptional Dynamics. (2019) (0)
Title Accelerating the Tempo of the Segmentation Clock byReducing the Number of Introns in the Hes 7 Gene (2018) (0)
Timing and shaping mechanisms of neural development (2019) (0)
Single-cell imaging of segmentation clock gene Hes7 for analyzing osillator phase coupling (2017) (0)
Title Hbp 1 regulates the timing of neuronal differentiation duringcortical development by controlling cell cycle progression (2019) (0)
Functional significance of adult neurogenesis in the mouse brain (2007) (0)
Author response: Fgf4 maintains Hes7 levels critical for normal somite segmentation clock function (2020) (0)
Generation of structurally and functionally distinct factors from the bHLH gene Hes3 by alternative first exons (2000) (0)
Cell differentiation. (1995) (0)
Retinoid Acid Specifies Neuronal Identity through Graded Expression of Ascl1 (2013) (0)
[Developmental chronobiology: two-hour cycle biological clocks]. (2004) (0)
DEV104497 3627..3636 (2014) (0)
Regulatory mechanisms of adult neurogenesis from neural stem cells (2011) (0)
Dynamic expression and roles of Hes factors in neural development (2014) (0)
Roles of the bHLH genes Hes1/Hes3/Hes5 in neural development (2006) (0)
[Biological clock as a conductor for embryogenesis]. (2006) (0)
Time-Lapse Bioluminescence Imaging of Hes7 Expression In Vitro and Ex Vivo. (2022) (0)
Title Dynamic regulation of Notch signaling in neural progenitor cells (2017) (0)

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What Schools Are Affiliated With Ryoichiro Kageyama?

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