Steven S. Clark
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Steven S. Clarkbiology Degrees
Biology
#9743
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#12984
Historical Rank
Immunology
#588
World Rank
#607
Historical Rank

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Biology
Steven S. Clark's Degrees
- PhD Immunology Stanford University
- Doctorate Medicine University of California, San Francisco
Why Is Steven S. Clark Influential?
(Suggest an Edit or Addition)Steven S. Clark's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes (1989) (2070)
- The human hematopoietic colony-stimulating factors. (1987) (1630)
- Correlations and interactions in the production of interleukin-6 (IL-6), IL-1, and tumor necrosis factor (TNF) in human blood mononuclear cells: IL-6 suppresses IL-1 and TNF. (1990) (1034)
- Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers (1991) (1013)
- Interleukin 6 enhancement of interleukin 3-dependent proliferation of multipotential hemopoietic progenitors. (1987) (836)
- Human IL-3 (multi-CSF): Identification by expression cloning of a novel hematopoietic growth factor related to murine IL-3 (1986) (758)
- Recombinant human granulocyte-macrophage colony-stimulating factor stimulates in vitro mature human neutrophil and eosinophil function, surface receptor expression, and survival. (1986) (733)
- Response of resting human peripheral blood natural killer cells to interleukin 2 (1984) (617)
- Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine. (1990) (607)
- Human granulocyte-macrophage colony-stimulating factor is a neutrophil activator (1985) (527)
- Multiple actions of interleukin 6 within a cytokine network. (1988) (511)
- Biologic properties in vitro of a recombinant human granulocyte-macrophage colony-stimulating factor. (1986) (460)
- Purified human granulocyte-macrophage colony-stimulating factor: direct action on neutrophils. (1984) (450)
- Stimulation of haematopoiesis in primates by continuous infusion of recombinant human GM-CSF (1986) (396)
- B cell stimulatory factor-2 is involved in the differentiation of cytotoxic T lymphocytes. (1988) (381)
- A mechanism underlying synergy between IL-12 and IFN-gamma-inducing factor in enhanced production of IFN-gamma. (1997) (355)
- Human recombinant granulocyte-macrophage colony-stimulating factor: a multilineage hematopoietin. (1985) (354)
- Synergism between interleukin-6 and interleukin-3 in supporting proliferation of human hematopoietic stem cells: comparison with interleukin-1 alpha. (1988) (338)
- Molecular cloning of a cDNA encoding a human macrophage migration inhibitory factor. (1989) (334)
- B-cell-stimulatory factor 2 (beta 2 interferon) functions as a second signal for interleukin 2 production by mature murine T cells. (1987) (330)
- Human recombinant granulocyte-macrophage colony-stimulating factor increases cell-to-cell adhesion and surface expression of adhesion-promoting surface glycoproteins on mature granulocytes. (1986) (278)
- Leukaemia inhibitory factor is identical to the myeloid growth factor human interleukin for DA cells (1988) (278)
- Release of early human hematopoietic progenitors from quiescence by antisense transforming growth factor beta 1 or Rb oligonucleotides (1991) (271)
- Granulocyte colony-stimulating factor enhances interleukin 3-dependent proliferation of multipotential hemopoietic progenitors. (1988) (271)
- Molecular characterization and expression of the gene encoding human erythroid-potentiating activity (1985) (268)
- Analysis in serum-free culture of the targets of recombinant human hemopoietic growth factors: interleukin 3 and granulocyte/macrophage-colony-stimulating factor are specific for early developmental stages. (1988) (251)
- Direct and synergistic effects of interleukin 11 on murine hemopoiesis in culture. (1991) (235)
- Stimulation of murine hemopoietic colony formation by human IL-6. (1988) (233)
- Activation of neutrophils by recombinant interleukin 6. (1989) (225)
- Growth factor requirements for survival in G0 and entry into the cell cycle of primitive human hemopoietic progenitors. (1992) (220)
- Recombinant gibbon interleukin 3 supports formation of human multilineage colonies and blast cell colonies in culture: comparison with recombinant human granulocyte-macrophage colony-stimulating factor. (1987) (219)
- Suppression of in vitro haematopoiesis following human immunodeficiency virus infection (1987) (218)
- The effects of three recombinant growth factors, IL-3, GM-CSF, and G-CSF, on the blast cells of acute myeloblastic leukemia maintained in short-term suspension culture. (1987) (213)
- Comparison of the effects of IL-3, granulocyte-macrophage colony-stimulating factor, and macrophage colony-stimulating factor in supporting monocyte differentiation in culture. Analysis of macrophage antibody-dependent cellular cytotoxicity. (1990) (200)
- Release from quiescence of CD34+ CD38- human umbilical cord blood cells reveals their potentiality to engraft adults. (1993) (198)
- Stimulation of proliferation, differentiation, and function of human cells by primate interleukin 3. (1987) (197)
- Molecular characterization of genome of a novel human T-cell leukaemia virus (1983) (191)
- Production of hematopoietic colony-stimulating factors by human natural killer cells (1989) (189)
- Synergistic factors for stem cell proliferation: further studies of the target stem cells and the mechanism of stimulation by interleukin-1, interleukin-6, and granulocyte colony-stimulating factor. (1988) (178)
- Recombinant human granulocyte/macrophage colony-stimulating factor activates intracellular killing of Leishmania donovani by human monocyte-derived macrophages (1987) (174)
- A possible autocrine role for interleukin-6 in two lymphoma cell lines. (1989) (173)
- Enhancement of murine hematopoiesis by synergistic interactions between steel factor (ligand for c-kit), interleukin-11, and other early acting factors in culture. (1992) (171)
- The flt3 ligand supports proliferation of lymphohematopoietic progenitors and early B-lymphoid progenitors. (1995) (171)
- Recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF) shortens the period of neutropenia after autologous bone marrow transplantation in a primate model. (1987) (166)
- Growth regulation of human acute myeloid leukemia: effects of five recombinant hematopoietic factors in a serum-free culture system (1988) (161)
- Purification of fetal hematopoietic progenitors and demonstration of recombinant multipotential colony-stimulating activity. (1985) (159)
- Clonal proliferation of murine lymphohemopoietic progenitors in culture. (1992) (158)
- Differential capacities of CD4+, CD8+, and CD4-CD8- T cell subsets to express IL-18 receptor and produce IFN-gamma in response to IL-18. (1998) (143)
- Human recombinant granulocyte-macrophage colony stimulating factor and interleukin 3 have overlapping but distinct hematopoietic activities. (1988) (142)
- M‐07e human leukemic factor‐dependent cell line provides a rapid and sensitive bioassay for the human cytokines GM‐CSF and IL‐3 (1990) (139)
- The interleukin 3 gene is located on human chromosome 5 and is deleted in myeloid leukemias with a deletion of 5q. (1987) (136)
- Sequence similarity between NKSF and the IL-6/G-CSF family. (1992) (135)
- Stimulation of human hematopoietic colony formation by recombinant gibbon multi-colony-stimulating factor or interleukin 3. (1987) (134)
- Recombinant human interleukin-3 and granulocyte-macrophage colony-stimulating factor show common biological effects and binding characteristics on human monocytes. (1989) (129)
- Interleukin‐1 regulation of hematopoietic growth factor production by human stromal fibroblasts (1988) (128)
- Stage-specific expression of c-kit protein by murine hematopoietic progenitors. (1993) (127)
- The myeloid blood cell differentiation-inducing protein MGI-2A is interleukin-6 (1988) (121)
- Effects of hematopoietic growth factors on the survival of primitive stem cells in liquid suspension culture. (1991) (118)
- Leukemia inhibitory factor differentiation-inhibiting activity/human interleukin for DA cells augments proliferation of human hematopoietic stem cells. (1990) (117)
- Interleukin-6 enhances growth factor-dependent proliferation of the blast cells of acute myeloblastic leukemia. (1988) (116)
- Reciprocal inhibition of binding between interleukin 3 and granulocyte-macrophage colony-stimulating factor to human eosinophils. (1989) (112)
- Demonstration of burst-promoting activity of recombinant human GM-CSF on circulating erythroid progenitors using an assay involving the delayed addition of erythropoietin. (1985) (111)
- The human genes for GM-CSF and IL 3 are closely linked in tandem on chromosome 5 (1988) (108)
- Human thymic epithelial cells produce IL-6, granulocyte-monocyte-CSF, and leukemia inhibitory factor. (1990) (108)
- Human P40 T-cell growth factor (interleukin-9) supports erythroid colony formation. (1990) (107)
- The effect of recombinant GM-CSF on the recovery of monkeys transplanted with autologous bone marrow. (1987) (104)
- Growth of human hemopoietic colonies in response to recombinant gibbon interleukin 3: comparison with human recombinant granulocyte and granulocyte-macrophage colony-stimulating factor. (1987) (104)
- Interleukin 1 enhances growth factor-dependent proliferation of the clonogenic cells in acute myeloblastic leukemia and of normal human primitive hemopoietic precursors (1988) (101)
- Expression of human interleukin-3 (multi-CSF) is restricted to human lymphocytes and T-cell tumor lines. (1989) (100)
- Decreased G-CSF and IL-3 Production and Gene Expression from Mononuclear Cells of Newborn Infants (1992) (99)
- Recombinant human interleukin-3 stimulation of hematopoiesis in humans: loss of responsiveness with differentiation in the neutrophilic myeloid series. (1988) (97)
- The myeloid blood cell differentiation-inducing protein MGI-2A is interleukin-6. (1988) (94)
- Negative regulation of early B lymphopoiesis by interleukin 3 and interleukin 1 alpha. (1994) (92)
- Synergistic and antagonistic effects of recombinant human interleukin (IL) 3, IL-1 alpha, granulocyte and macrophage colony-stimulating factors (G-CSF and M-CSF) on the growth of GM-CSF-dependent leukemic cell lines. (1987) (87)
- Amplification of IL-2-driven T cell proliferation by recombinant human IL-3 and granulocyte-macrophage colony-stimulating factor. (1988) (87)
- Interleukin-11 stimulates multiple phases of erythropoiesis in vitro. (1992) (86)
- Human T-cell growth factor: partial amino acid sequence, cDNA cloning, and organization and expression in normal and leukemic cells. (1984) (84)
- Structure and expression of genes of GM-CSF and G-CSF in blast cells from patients with acute myeloblastic leukemia. (1988) (84)
- Synergistic interaction between interleukin-12 and steel factor in support of proliferation of murine lymphohematopoietic progenitors in culture. (1994) (83)
- Growth factor requirement for survival in cell-cycle dormancy of primitive murine lymphohematopoietic progenitors. (1993) (81)
- Chimeric mouse tumor models reveal differences in pathway activation between ERBB family– and KRAS-dependent lung adenocarcinomas (2010) (77)
- Recombinant gibbon interleukin-3 acts synergistically with recombinant human G-CSF and GM-CSF in vitro. (1988) (75)
- The effects of combinations of the recombinant growth factors GM-CSF, G-CSF, IL-3, and CSF-1 on leukemic blast cells in suspension culture. (1988) (68)
- Expression cloning of cDNA encoding a novel human hematopoietic growth factor: human homologue of murine T-cell growth factor P40. (1989) (66)
- The murine Il-6 gene maps to the proximal region of chromosome 5. (1989) (66)
- Erythroid burst-promoting activity of purified recombinant human GM-CSF and interleukin-3: studies with anti-GM-CSF and anti-IL-3 sera and studies in serum-free cultures. (1988) (63)
- Progenitor cell hyperplasia with rare development of myeloid leukemia in interleukin 11 bone marrow chimeras (1993) (62)
- Granulocyte-macrophage colony-stimulating factor is an endogenous regulator of cell proliferation in juvenile chronic myelogenous leukemia. (1989) (60)
- Binding of iodinated recombinant human GM-CSF to the blast cells of acute myeloblastic leukemia. (1988) (59)
- Interleukin-3 and interleukin-1 alpha allow earlier bone marrow progenitors to respond to human colony-stimulating factor 1. (1988) (58)
- The effects of recombinant CSF‐1 on the blast cells of acute myeloblastic leukemia in suspension culture (1988) (57)
- Characterization of granulocyte-macrophage colony-stimulating factor receptor on the blast cells of acute myeloblastic leukemia. (1990) (55)
- Establishment of a novel heterotransplantable acute lymphoblastic leukemia cell line with a t(17;19) chromosomal translocation the growth of which is inhibited by interleukin-3. (1991) (52)
- Human recombinant IL-3 stimulates B cell differentiation. (1989) (49)
- Modest stimulatory effect of recombinant human GM-CSF on colony growth from peripheral blood human megakaryocyte progenitor cells. (1987) (48)
- Survival of hemopoietic progenitors in the G0 period of the cell cycle does not require early hemopoietic regulators. (1989) (48)
- Specific binding, internalization, and degradation of human recombinant interleukin‐3 by cells of the acute myelogenous, leukemia line, KG‐1 (1988) (47)
- Studies of thyroglobulin autoantibody synthesis using a micro-ELISA assay. (1982) (47)
- Maturation of human acute myeloid leukaemia in vitro; the response to five recombinant haematopoietic factors in a serum‐free system (1989) (43)
- De novo discovery of a gamma-secretase inhibitor response signature using a novel in vivo breast tumor model. (2009) (43)
- The human genes for GM-CSF and IL 3 are closely linked in tandem on chromosome 5. (1988) (42)
- Recombinant gibbon interleukin‐3 stimulates megakaryocyte colony growth in vitro from human peripheral blood progenitor cells (1988) (40)
- Synergistic actions of stem cell factor and other burst-promoting activities on proliferation of CD34+ highly purified blood progenitors expressing HLA-DR or different levels of c-kit protein. (1994) (39)
- Synergistic interactions between interleukin-11 and interleukin-4 in support of proliferation of primitive hematopoietic progenitors of mice. (1991) (39)
- Crucial Role of the Residue R280 at the F′–G′ Loop of the Human Granulocyte/Macrophage Colony-stimulating Factor Receptor α Chain for Ligand Recognition (1997) (36)
- Biological activities of human granulocyte-macrophage colony-stimulating factor. (1988) (35)
- Synergistic interaction between interleukin-6 and interleukin-3 in support of stem cell proliferation in culture. (1988) (35)
- Interleukin‐6 production by the blast cells of acute myeloblastic leukemia: Regulation by endogenous interleukin‐1 and biological implications (1991) (34)
- In vitro production of granulocyte-macrophage colony-stimulating factor in aplastic anemia: possible mechanisms of action of antithymocyte globulin. (1991) (33)
- IL-3 inhibits the binding of GM-CSF to AML blasts, but the two cytokines act synergistically in supporting blast proliferation. (1990) (33)
- Composition and functional integrity of the in vitro hemopoietic microenvironment in acute myelogenous leukemia: effect of macrophage colony-stimulating factor. (1992) (30)
- Additive effects of steel factor and antisense TGF-beta 1 oligodeoxynucleotide on CD34+ hematopoietic progenitor cells. (1994) (29)
- Specific binding of human interleukin-3 and granulocyte-macrophage colony-stimulating factor to human basophils. (1990) (29)
- Interleukin 6: identification as a hematopoietic colony-stimulating factor. (1988) (28)
- Identification through chemical cross-linking of distinct granulocyte-macrophage colony-stimulating factor and interleukin-3 receptors on myeloid leukemic cells, KG-1. (1989) (28)
- Interleukin-3: molecular biology and biologic activities. (1989) (27)
- In polycythemia vera human interleukin 3 and granulocyte-macrophage colony-stimulating factor enhance erythroid colony growth in the absence of erythropoietin. (1989) (25)
- Interleukin 2 enhances natural killing of varicella-zoster virus-infected targets. (1986) (25)
- Human interleukin-4 inhibits proliferation of megakaryocyte progenitor cells in culture (1993) (24)
- Expression of the CSF‐1 gene in the blast cells of acute myeloblastic leukemia: Association with reduced growth capacity (1988) (24)
- Effects of interleukin‐12 on natural killer cell cytotoxicity and the production of interferon‐7 and tumour necrosis factor‐a in patients with myelodysplastic syndromes (1995) (23)
- Molecular Determinants of the Granulocyte-Macrophage Colony-stimulating Factor Receptor Complex Assembly* (1999) (22)
- Transcriptional modulation of human IL-6 gene expression by verapamil. (1990) (22)
- Serum-free culture of enriched hematopoietic progenitors reflects physiologic levels of fetal hemoglobin biosynthesis. (1990) (20)
- Basic biology of the hematopoietic growth factors. (1992) (19)
- Inhibition of hematopoiesis in normal human long-term marrow cultures treated with recombinant human macrophage colony-stimulating factor. (1991) (19)
- Human B cell proliferation in response to IL-4 is associated with enhanced production of B cell-derived growth factors. (1989) (18)
- Human interleukin‐9 supports formation of a subpopulation of erythroid bursts that are responsive to interleukin‐3 (1992) (18)
- Combinations of stem cell factor with other hematopoietic growth factors enhance growth and sensitivity to cytosine arabinoside of blast progenitors in acute myelogenous leukemia. (1994) (17)
- Molecular Cloning of a Primate cDNA and the Human Gene for Interleukin 3 (1988) (17)
- Human interleukin-4 inhibits proliferation of megakaryocyte progenitor cells in culture. (1993) (16)
- Interleukin-4 as a growth regulator of clonogenic cells in acute myelogenous leukemia in suspension culture. (1991) (16)
- Effects of Interleukin-11 on the Proliferation and Cell Cycle Status of Myeloid Leukemic Cells (1993) (16)
- Immunogenotypes and clonal culture analysis in B-precursor acute lymphoblastic leukemia. (1992) (13)
- Generation of mature CD3+ and T cell receptor (TCR) + T cells from a leukemic analogue of the putative human stem cell by T cell conditioned medium containing IL-3, IL-2, and GM-CSF. (1988) (13)
- The structure and dynamics of the granulocyte macrophage colony-stimulating factor receptor defined by the ternary complex model. (1993) (13)
- The interleukin 3 gene is located on human chromosome 5 and is deleted in myeloid leukemias with a deletion of 5 q ( gene mapping / hematopoietic growth factors / chromosomal deletions / malignant transformation ) (12)
- Sequential Administration of Interleukin-6 and Granulocyte-Colony Stimulating Factor in Newborn Rats: Modulation of Newborn Granulopoiesis and Thrombopoiesis (1991) (12)
- Effect of rhCSF-1 on human hemopoiesis in long-term cultures from patients with acute myelogenous leukemia. (1991) (11)
- DEFICIENT T CELL GRANULOCYTE‐MACROPHAGE COLONY STIMULATING FACTOR PRODUCTION IN ALLOGENEIC BONE MARROW TRANSPLANT RECIPIENTS (1990) (10)
- Deletion of carboxy-terminal residues of murine granulocyte-macrophage colony-stimulating factor results in a loss of biologic activity and altered glycosylation. (1990) (9)
- The role of interleukin-6 in mitogenic T-cell activation: detection of interleukin-2 heteronuclear RNA by polymerase chain reaction. (1991) (8)
- Effects of interferons and interleukin 2 on natural killing of cytomegalovirus-infected fibroblasts. (1987) (8)
- Structure of the gene for human interleukin-3 or multi-CSF. (1987) (6)
- Molecular cloning and biological characterization of human interleukin-3 (IL-3). (1989) (6)
- Human interleukin 3: analysis of the gene and its role in the regulation of hematopoiesis. (1990) (6)
- Effects of lethal irradiation and cyclosporin A treatment on the growth and tumoricidal activity of a T cell clone potentially useful in cancer therapy (1995) (5)
- Induction of IgE synthesis in anti-IgM-activated nonatopic human B cells by recombinant interleukin-3. (1989) (5)
- Thrombopoiesis and thrombopoietin: the significance of "non-Tpo" cytokines. (1996) (5)
- Cytokine modulation of the susceptibility of acute T-lymphoblastic leukemia cell lines to LAK activity. (1993) (4)
- Autocrine transforming growth factor-β controls G0 phase of early human hematopoietic progenitors in serum- or serum-free culture (1991) (4)
- Biological and molecular evidence for the production of IL-6 by human natural killer cells in culture. (1989) (4)
- Granulocyte colony-stimulating factors as therapeutic agents. (1992) (3)
- Response to IL-18 γ and Produce IFN-T Cell Subsets to Express IL-18 Receptor − CD 8 − , and CD 4 + , CD 8 + Differential Capacities of CD 4 (1998) (3)
- Autocrine Transforming Growth-Factor-Beta Controls G0 Phase of Early Human Hematopoietic Progenitors in Serum-Free or Serum-Free Culture (1991) (2)
- In vivo hematological effects of seven days of rhIL-6 in neonatal rats. (1992) (2)
- Molecular Cloning and Characterization of the Human Gene for Interleukin-3 (IL-3) (1987) (2)
- Primate hematopoietic growth factors IL-3 and pharmaceutical compositions (1990) (1)
- 4868119 Hematopoietic growth factors (1990) (1)
- The stem cell mavens had a blast. Second International Symposium on the Molecular Biology of Hematopoiesis, Innsbruck, Austria, July 14-18, 1991. (1992) (1)
- Antisense Oligonucleotides for Inhibitors and Tumor-Suppressor Genes Reveal the Hematopoietic Potential of Quiescent Progenitors (1993) (1)
- Essai de validation de cible (2006) (0)
- A process for producing a polypeptide of primate. (1987) (0)
- IL-3 protein, in particular human IL-3, its preparation and use in pharmaceuticals, vector encoding the protein, as well as cells transformed with the vector (1988) (0)
- interleukin-6 The myeloid blood cell differentiation-inducing protein MGI-2A is (2011) (0)
- Molecular cloning of a primate complementary dna and the human gene for interleukin 3 (1988) (0)
- Framstaellning Science purifying lymfokin. (1986) (0)
- Human IL-3 protein, pharmaceutical composition containing the protein, vector, coding for the protein, the cell transformed with (1988) (0)
- Preparation and Use of IL-6 (1987) (0)
- Procedes in vivo de validation du role d'un gene d'entretien tumoral (2003) (0)
- A process for producing an IL-6 protein. (1987) (0)
- antithymocyte globulin factor in aplastic anemia: possible mechanisms of action of In vitro production of granulocyte-macrophage colony-stimulating (2011) (0)
- A process for preparing M-CSF (1988) (0)
- Human Granulocyte/Macrophage Colony-stimulating Factor Receptor a Chain for Ligand Recognition (1997) (0)
- Family of IP3-like hematopoietic growth factors of primates (1987) (0)
- and Produce IFN- T Cell Subsets to Express IL-18 Receptor - CD8 - Differential Capacities of CD4+, CD8+, and CD4 (2013) (0)
- Preparation of M-CSF. (1987) (0)
- Potential therapeutic uses for hematopoietic colony stimulating factors. (1987) (0)
- Biology of growth factors: requirements for stem cell survival. (1991) (0)
- Treg GMP isolation for clinical trial in haematopoietic stem cell transplantation: lessons and experience (2011) (0)
- Hematopoiesis : proceedings of a UCLA Symposium held at Tamarron, Colorado, February 20-26, 1989 (1990) (0)
- Molecular Cloning of the Human CSF Complementary DNAs (2015) (0)
- Human cytokine, interleukin-9 (1990) (0)
- Chronic Myelogenous Leukemia as a Model System for Stem Cell Growth Regulation and Hematolymphoid Development (1986) (0)
- The method of producing a non-human primate IL-3 protein and recombinant protein encoding DNA sequence (1989) (0)
- Natural killer cell-stimulation factor (1989) (0)
- chromosome 5 The human genes for GM-CSF and IL 3 are closely linked in tandem on (2011) (0)
- A process for the treatment of damaged or reduced cells (1993) (0)
- Abstract 642: Novel EGFR inhibitory antibodies directed against EGFR mutants with potentially reduced toxicity (2011) (0)
- A process for producing m-csf (1987) (0)
- A process for the treatment of damaged cells and reduced (1993) (0)
- Production et purification de lymphokine (1985) (0)
- Process for treating injury or cell decreases. (1993) (0)
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Steven S. Clark is affiliated with the following schools: