Shoukat Dedhar
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Chemistry Biology
Shoukat Dedhar's Degrees
- PhD Biochemistry University of British Columbia
- Masters Chemistry University of British Columbia
- Bachelors Chemistry University of British Columbia
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(Suggest an Edit or Addition)Shoukat Dedhar's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The epithelial–mesenchymal transition: new insights in signaling, development, and disease (2006) (2006)
- Regulation of cell adhesion and anchorage-dependent growth by a new β1-integrin-linked protein kinase (1996) (1154)
- Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase. (1998) (1124)
- Guidelines and definitions for research on epithelial–mesenchymal transition (2020) (778)
- Reciprocal interactions between beta1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: a different perspective in epithelial biology. (1998) (691)
- Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors. (2011) (615)
- Integrin-linked kinase: a cancer therapeutic target unique among its ILK (2005) (605)
- NGF-Induced Axon Growth Is Mediated by Localized Inactivation of GSK-3β and Functions of the Microtubule Plus End Binding Protein APC (2004) (542)
- Snail Induction of Epithelial to Mesenchymal Transition in Tumor Cells Is Accompanied by MUC1 Repression andZEB1 Expression* (2002) (468)
- Cell adhesion and the integrin-linked kinase regulate the LEF-1 and beta-catenin signaling pathways. (1998) (461)
- Ureido-substituted benzenesulfonamides potently inhibit carbonic anhydrase IX and show antimetastatic activity in a model of breast cancer metastasis. (2011) (420)
- Integrin cytoplasmic interactions and bidirectional transmembrane signalling. (1996) (419)
- Interaction of nuclear receptors with the Wnt/beta-catenin/Tcf signaling axis: Wnt you like to know? (2005) (404)
- Calreticulin is essential for integrin-mediated calcium signalling and cell adhesion (1997) (403)
- Regulation of Protein Kinase B/Akt-Serine 473 Phosphorylation by Integrin-linked Kinase (2001) (394)
- Inhibition of nuclear hormone receptor activity by calreticulin (1994) (375)
- Cytoskeletal rearrangements accompanying salmonella entry into epithelial cells. (1991) (374)
- Recent Developments in Targeting Carbonic Anhydrase IX for Cancer Therapeutics (2012) (368)
- Regulation of Snail transcription during epithelial to mesenchymal transition of tumor cells (2004) (332)
- Integrin-linked kinase – essential roles in physiology and cancer biology (2008) (331)
- Integrin-linked Protein Kinase Regulates Fibronectin Matrix Assembly, E-cadherin Expression, and Tumorigenicity* (1998) (298)
- Conditional Knock-out of Integrin-linked Kinase Demonstrates an Essential Role in Protein Kinase B/Akt Activation* (2003) (296)
- Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche (2013) (287)
- A cell surface receptor complex for collagen type I recognizes the Arg- Gly-Asp sequence (1987) (284)
- Overexpression of the Integrin-linked Kinase Promotes Anchorage-independent Cell Cycle Progression* (1997) (281)
- Regulation of tumor angiogenesis by integrin-linked kinase (ILK). (2004) (277)
- Akt phosphorylates the Y-box binding protein 1 at Ser102 located in the cold shock domain and affects the anchorage-independent growth of breast cancer cells (2005) (277)
- Inhibition of integrin linked kinase (ILK) suppresses β-catenin-Lef/Tcf-dependent transcription and expression of the E-cadherin repressor, snail, in APC−/− human colon carcinoma cells (2001) (274)
- Tumor Suppressor Pten Inhibits Nuclear Accumulation of β-Catenin and T Cell/Lymphoid Enhancer Factor 1–Mediated Transcriptional Activation (2001) (267)
- Reduced contact-inhibition and substratum adhesion in epithelial cells expressing GlcNAc-transferase V (1995) (265)
- The Integrin-linked Kinase Regulates the Cyclin D1 Gene through Glycogen Synthase Kinase 3β and cAMP-responsive Element-binding Protein-dependent Pathways* (2000) (264)
- The integrin-linked kinase (ILK) suppresses anoikis (2000) (264)
- Integrin-linked kinase (ILK): a regulator of integrin and growth-factor signalling. (1999) (256)
- Integrin expression in human bone (1993) (251)
- Reduced chondrocyte proliferation and chondrodysplasia in mice lacking the integrin-linked kinase in chondrocytes (2003) (239)
- Alterations in integrin receptor expression on chemically transformed human cells: specific enhancement of laminin and collagen receptor complexes (1990) (237)
- Cell-substrate interactions and signaling through ILK. (2000) (235)
- Neuroprotection via matrix-trophic coupling between cerebral endothelial cells and neurons (2008) (234)
- Rictor and integrin-linked kinase interact and regulate Akt phosphorylation and cancer cell survival. (2008) (232)
- In vitro interaction of a polypeptide homologous to human Ro/SS-A antigen (calreticulin) with a highly conserved amino acid sequence in the cytoplasmic domain of integrin alpha subunits. (1991) (232)
- Human granulocyte-macrophage colony-stimulating factor is a growth factor active on a variety of cell types of nonhemopoietic origin. (1988) (224)
- Glycosyl coumarin carbonic anhydrase IX and XII inhibitors strongly attenuate the growth of primary breast tumors. (2011) (223)
- Mini-Review Integrin-linked kinase (ILK) and its interactors: a new paradigm for the coupling of extracellular matrix to actin cytoskeleton and signaling (2001) (211)
- Integrin-linked kinase (ILK) and its interactors (2001) (211)
- Molecular pathways regulating EGF-induced epithelio-mesenchymal transition in human ovarian surface epithelium. (2006) (201)
- SPARC Regulates Extracellular Matrix Organization through Its Modulation of Integrin-linked Kinase Activity* (2005) (201)
- PTEN and GSK3β: key regulators of progression to androgen-independent prostate cancer (2006) (198)
- Signaling through beta-catenin and Lef/Tcf. (1999) (191)
- The integrin linked kinase (ILK) induces an invasive phenotype via AP-1 transcription factor-dependent upregulation of matrix metalloproteinase 9 (MMP-9) (2000) (189)
- Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase. (2004) (188)
- The role of integrin-linked kinase (ILK) in cancer progression (2003) (183)
- Cell-Extracellular Matrix Interactions Stimulate the AP-1 Transcription Factor in an Integrin-Linked Kinase- and Glycogen Synthase Kinase 3-Dependent Manner (1999) (177)
- Inactivation of the Hippo tumour suppressor pathway by integrin-linked kinase (2013) (175)
- Endothelin-1 promotes epithelial-to-mesenchymal transition in human ovarian cancer cells. (2005) (171)
- Targeted ablation of ILK from the murine heart results in dilated cardiomyopathy and spontaneous heart failure. (2006) (169)
- Bi-directional signal transduction by integrin receptors. (2000) (167)
- Signaling through β-catenin and Lef/Tcf (1999) (166)
- Podocyte-specific deletion of integrin-linked kinase results in severe glomerular basement membrane alterations and progressive glomerulosclerosis. (2006) (165)
- Integrin-Linked Kinase at the Heart of Cardiac Contractility, Repair, and Disease (2007) (157)
- Novel functions for calreticulin: interaction with integrins and modulation of gene expression? (1994) (156)
- Cell attachment to extracellular matrix substrates is inhibited upon downregulation of expression of calreticulin, an intracellular integrin alpha-subunit-binding protein. (1994) (151)
- Inducible interaction of integrin alpha 2 beta 1 with calreticulin. Dependence on the activation state of the integrin. (1995) (143)
- ILK mediates actin filament rearrangements and cell migration and invasion through PI3K/Akt/Rac1 signaling (2005) (142)
- Essential role of integrin-linked kinase in podocyte biology: Bridging the integrin and slit diaphragm signaling. (2006) (142)
- Integrin-Linked Kinase Regulates Endothelial Cell Survival and Vascular Development (2004) (141)
- Integration of cell attachment, cytoskeletal localization, and signaling by integrin-linked kinase (ILK), CH-ILKBP, and the tumor suppressor PTEN. (2003) (141)
- Preferential dependence of breast cancer cells versus normal cells on integrin-linked kinase for protein kinase B/Akt activation and cell survival. (2006) (139)
- Mammary epithelial-specific expression of the integrin linked kinase (ILK) results in the induction of mammary gland hyperplasias and tumors in transgenic mice (2001) (138)
- The receptor for the basement membrane glycoprotein entactin is the integrin alpha 3/beta 1. (1992) (136)
- Integrin-linked kinase localizes to the centrosome and regulates mitotic spindle organization (2008) (136)
- αv integrins regulate cell proliferation through integrin-linked kinase (ILK) in ovarian cancer cells (2003) (134)
- Heart, brain, and body wall defects in mice lacking calreticulin. (2000) (133)
- Rat Seminiferous Epithelium Contains a Unique Junction (Ectoplasmic Specialization) with Signaling Properties Both of Cell/Cell and Cell/Matrix Junctions (2001) (133)
- Integrin-linked kinase: Not so ‘pseudo’ after all (2011) (131)
- Role of the integrin-linked kinase (ILK)/Rictor complex in TGFβ-1-induced epithelial–mesenchymal transition (EMT) (2013) (127)
- Stimulation of tyrosine phosphorylation and accumulation of GTP-bound p21ras upon antibody-mediated alpha 2 beta 1 integrin activation in T-lymphoblastic cells. (1993) (127)
- Immunohistochemical localization of vitronectin, its receptor and beta-3 integrin in Alzheimer brain tissue (1991) (127)
- Regulation of pH by Carbonic Anhydrase 9 Mediates Survival of Pancreatic Cancer Cells With Activated KRAS in Response to Hypoxia. (2019) (126)
- Integrin-Linked Kinase Deletion from Mouse Cortex Results in Cortical Lamination Defects Resembling Cobblestone Lissencephaly (2005) (119)
- Epithelial–mesenchymal transition (EMT) is not sufficient for spontaneous murine breast cancer metastasis (2008) (118)
- Integrins and tumor invasion (1990) (118)
- Overexpression of the integrin-linked kinase mesenchymally transforms mammary epithelial cells. (2001) (117)
- Reciprocal interactions between human ovarian surface epithelial cells and adjacent extracellular matrix. (1994) (116)
- Inhibition of ILK in PTEN-mutant human glioblastomas inhibits PKB/Akt activation, induces apoptosis, and delays tumor growth (2005) (113)
- Targeting hypoxic tumour cells to overcome metastasis (2011) (109)
- Carbonic anhydrase IX promotes myeloid-derived suppressor cell mobilization and establishment of a metastatic niche by stimulating G-CSF production. (2015) (105)
- Overcoming Hypoxia-Mediated Tumor Progression: Combinatorial Approaches Targeting pH Regulation, Angiogenesis and Immune Dysfunction (2016) (105)
- Modulation of Wnt3a-mediated nuclear β-catenin accumulation and activation by integrin-linked kinase in mammalian cells (2006) (104)
- Mapping the integrin-linked kinase interactome using SILAC. (2008) (101)
- Role of Integrin-Linked Kinase in Nerve Growth Factor-Stimulated Neurite Outgrowth (2003) (100)
- Human osteosarcoma cells resistant to detachment by an Arg-Gly-Asp- containing peptide overproduce the fibronectin receptor (1987) (97)
- Neurotrophins support regenerative axon assembly over CSPGs by an ECM-integrin-independent mechanism (2006) (96)
- PTEN and GSK3beta: key regulators of progression to androgen-independent prostate cancer. (2006) (94)
- Dysregulation of integrin-linked kinase (ILK) signaling in colonic polyposis (2001) (93)
- Liver‐specific ablation of integrin‐linked kinase in mice results in abnormal histology, enhanced cell proliferation, and hepatomegaly (2008) (93)
- A Phase 1 Study of SLC-0111, a Novel Inhibitor of Carbonic Anhydrase IX, in Patients With Advanced Solid Tumors (2020) (91)
- Integrin-Linked Kinase Is a Functional Mn2+-Dependent Protein Kinase that Regulates Glycogen Synthase Kinase-3β (GSK-3β) Phosphorylation (2010) (88)
- A critical role of integrin-linked kinase, ch-TOG and TACC3 in centrosome clustering in cancer cells (2011) (87)
- Carbonic Anhydrase Inhibitors Targeting Metabolism and Tumor Microenvironment (2020) (87)
- Addition of carbonic anhydrase 9 inhibitor SLC-0111 to temozolomide treatment delays glioblastoma growth in vivo. (2017) (86)
- The interactome of metabolic enzyme carbonic anhydrase IX reveals novel roles in tumor cell migration and invadopodia/MMP14-mediated invasion (2017) (85)
- Targeting Hypoxia-Induced Carbonic Anhydrase IX Enhances Immune-Checkpoint Blockade Locally and Systemically (2019) (85)
- Integrin-linked Kinase Regulates Inducible Nitric Oxide Synthase and Cyclooxygenase-2 Expression in an NF-κB-dependent Manner* (2002) (83)
- Tubular epithelial cell dedifferentiation is driven by the helix-loop-helix transcriptional inhibitor Id1. (2007) (82)
- Integrin-linked kinase activity regulates Rac- and Cdc42-mediated actin cytoskeleton reorganization via α-PIX (2005) (81)
- Targeting hypoxic response for cancer therapy (2016) (81)
- alpha(v) integrins regulate cell proliferation through integrin-linked kinase (ILK) in ovarian cancer cells. (2003) (81)
- Integrin-linked kinase functions as a downstream mediator of endothelin-1 to promote invasive behavior in ovarian carcinoma (2006) (80)
- Regulation of expression of the cell adhesion receptors, integrins, by recombinant human interleukin‐1β in human osteosarcoma cells: Inhibition of cell proliferation and stimulation of alkaline phosphatase activity (1989) (79)
- An Essential Role for the Integrin-Linked Kinase–Glycogen Synthase Kinase-3β Pathway during Dendrite Initiation and Growth (2006) (78)
- Novel matrix metalloproteinase inhibitor [18F]marimastat-aryltrifluoroborate as a probe for in vivo positron emission tomography imaging in cancer. (2010) (76)
- Molecular dissection of integrin signalling proteins in the control of mammary epithelial development and differentiation (2009) (75)
- Integrin‐linked kinase is an essential link between integrins and uptake of bacterial pathogens by epithelial cells (2006) (74)
- Integrins and signal transduction. (1999) (73)
- Isolation of a novel integrin receptor mediating Arg-Gly-Asp-directed cell adhesion to fibronectin and type I collagen from human neuroblastoma cells. Association of a novel beta 1-related subunit with alpha v (1990) (73)
- Integrin‐linked kinase regulates E‐cadherin expression through PARP‐1 (2008) (71)
- BMP promotes motility and represses growth of smooth muscle cells by activation of tandem Wnt pathways (2011) (71)
- Ligand-specific, transient interaction between integrins and calreticulin during cell adhesion to extracellular matrix proteins is dependent upon phosphorylation/dephosphorylation events. (1999) (70)
- Impaired hair follicle morphogenesis and polarized keratinocyte movement upon conditional inactivation of integrin-linked kinase in the epidermis. (2008) (70)
- QLT0267, a small molecule inhibitor targeting integrin-linked kinase (ILK), and docetaxel can combine to produce synergistic interactions linked to enhanced cytotoxicity, reductions in P-AKT levels, altered F-actin architecture and improved treatment outcomes in an orthotopic breast cancer model (2009) (69)
- Signal transduction via the β1 integrins is a required intermediate in interleukin-1β induction of alkaline phosphatase activity in human osteosarcoma cells☆ (1989) (67)
- Suppression of VEGF secretion and changes in glioblastoma multiforme microenvironment by inhibition of Integrin-linked kinase (ILK) (2008) (66)
- The Role of Epithelial– Mesenchymal Transition in Cancer Metastasis (2015) (66)
- Integrin-linked kinase activity regulates Rac- and Cdc42-mediated actin cytoskeleton reorganization via alpha-PIX. (2005) (66)
- The role of integrin-linked kinase in melanoma cell migration, invasion, and tumor growth (2007) (65)
- Carbonic anhydrase IX (CAIX) as a mediator of hypoxia-induced stress response in cancer cells. (2014) (64)
- Inhibition of tumor cell invasion and angiogenesis by motuporamines. (2001) (64)
- Association of 1 alpha,25-dihydroxyvitamin D3-occupied vitamin D receptors with cellular membrane acceptance sites. (1996) (62)
- Synthesis and evaluation of 18F-labeled carbonic anhydrase IX inhibitors for imaging with positron emission tomography (2014) (62)
- A dual role for integrin-linked kinase in platelets: regulating integrin function and α-granule secretion (2008) (61)
- Role of the integrin-linked kinase/PINCH1/alpha-parvin complex in cardiac myocyte hypertrophy (2005) (61)
- Role of the integrin-linked kinase (ILK) in determining neuronal polarity. (2007) (60)
- Loss of integrin linked kinase from mouse hepatocytes in vitro and in vivo results in apoptosis and hepatitis (2007) (60)
- Combined inhibition of the phosphatidylinositol 3-kinase/Akt and Ras/mitogen-activated protein kinase pathways results in synergistic effects in glioblastoma cells (2006) (59)
- Targeted Deletion of Integrin-Linked Kinase Reveals a Role in T-Cell Chemotaxis and Survival (2005) (58)
- Critical Role of Integrin-Linked Kinase in Granule Cell Precursor Proliferation and Cerebellar Development (2006) (57)
- A methotrexate insensitive variant of folate reductase present in two lines of methotrexate-resistant L5178Y cells. (1980) (57)
- Novel Role for Integrin-Linked Kinase in Modulation of Coxsackievirus B3 Replication and Virus-Induced Cardiomyocyte Injury (2006) (57)
- Specific alterations in the expression of alpha 3 beta 1 and alpha 6 beta 4 integrins in highly invasive and metastatic variants of human prostate carcinoma cells selected by in vitro invasion through reconstituted basement membrane. (1993) (56)
- Integrin-linked Kinase Regulates the Nuclear Entry of the c-Jun Coactivator α-NAC and Its Coactivation Potency* (2004) (55)
- Suppression of Her2/neu expression through ILK inhibition is regulated by a pathway involving TWIST and YB-1 (2010) (55)
- Induction of expression of the alpha v beta 1 and alpha v beta 3 integrin heterodimers during retinoic acid-induced neuronal differentiation of murine embryonal carcinoma cells. (1991) (54)
- Integrin-linked kinase as a target for ERG-mediated invasive properties in prostate cancer models. (2012) (52)
- The importance of integrin‐linked kinase in the regulation of bladder cancer invasion (2012) (52)
- Characterisation of integrin-linked kinase signalling in sporadic human colon cancer (2003) (52)
- Protein kinase mediators of integrin signal transduction (1997) (50)
- Induction of the intestinal stem cell signature gene SMOC-2 is required for L1-mediated colon cancer progression (2016) (50)
- Role of Integrin-linked Kinase in Leukocyte Recruitment* (2002) (50)
- Integrin-linked kinase has a critical role in ErbB2 mammary tumor progression: implications for human breast cancer (2010) (49)
- Stimulation of tyrosine phosphorylation of distinct proteins in response to antibody-mediated ligation and clustering of alpha 3 and alpha 6 integrins. (1995) (48)
- Aortic Aneurysm Generation in Mice With Targeted Deletion of Integrin-Linked Kinase in Vascular Smooth Muscle Cells (2011) (48)
- Genome-wide synthetic lethal screen unveils novel CAIX-NFS1/xCT axis as a targetable vulnerability in hypoxic solid tumors (2021) (47)
- Mapping of the gene encoding the integrin-linked kinase, ILK, to human chromosome 11p15.5-p15.4. (1997) (47)
- Discovery of 4-Hydroxy-3-(3-(phenylureido)benzenesulfonamides as SLC-0111 Analogues for the Treatment of Hypoxic Tumors Overexpressing Carbonic Anhydrase IX. (2018) (47)
- Inhibition of the phosphatidylinositol 3'-kinase pathway promotes autocrine Fas-induced death of phosphatase and tensin homologue-deficient prostate cancer cells. (2006) (46)
- Specific alterations in the expression of α3β1 and α6β4 integrins in highly invasive and metastatic variants of human prostate carcinoma cells selected by in vitro invasion through reconstituted basement membrane (1993) (45)
- Integrin-linked kinase regulates cell proliferation and tumour growth in murine colitis-associated carcinogenesis (2008) (44)
- Distribution of integrins on human peripheral blood mononuclear cells. (1989) (44)
- The effect of GM‐CSF and G‐CSF on the growth of human osteosarcoma cells in vitro and in vivo (1994) (42)
- Constitutive expression of calreticulin in osteoblasts inhibits mineralization (1995) (41)
- Specific and sensitive combined high-performance liquid chromatographic-flow fluorometric assay for intracellular 6-thioguanine nucleotides metabolites of 6-mercaptopurine and 6-thioguanine. (1978) (41)
- Immunostaining of human brain capillaries by antibodies to very late antigens (1990) (40)
- Combined inhibition of integrin linked kinase and FMS-like tyrosine kinase 3 is cytotoxic to acute myeloid leukemia progenitor cells. (2009) (39)
- Coordinated Regulation of Metabolic Transporters and Migration/Invasion by Carbonic Anhydrase IX (2018) (38)
- Beyond focal adhesions: Integrin linked kinase associates with tubulin and regulates mitotic spindle organization (2008) (36)
- Overcoming Adaptive Resistance to KRAS and MEK Inhibitors by Co-targeting mTORC1/2 Complexes in Pancreatic Cancer (2020) (35)
- Transformation-associated alterations in interactions between pre-B cells and fibronectin. (1990) (35)
- Identification of novel small molecule inhibitors of centrosome clustering in cancer cells (2013) (34)
- The Tumor Invasion Inhibitor Dihydromotuporamine C Activates RHO, Remodels Stress Fibers and Focal Adhesions, and Stimulates Sodium–Proton Exchange (2004) (34)
- Deletion of Integrin-Linked Kinase from Skeletal Muscles of Mice Resembles Muscular Dystrophy Due to α7β1-Integrin Deficiency (2007) (34)
- The osteoblast-like differentiated phenotype of a variant of MG-63 osteosarcoma cell line correlated with altered adhesive properties. (1989) (33)
- Cooperative signaling between Wnt1 and integrin-linked kinase induces accelerated breast tumor development (2010) (33)
- Stat3 regulates centrosome clustering in cancer cells via Stathmin/PLK1 (2017) (33)
- Development and assessment of conventional and targeted drug combinations for use in the treatment of aggressive breast cancers. (2006) (32)
- β1 integrin, ILK and mTOR regulate collagen synthesis in mechanically loaded tendon cells (2020) (32)
- Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition. (2017) (31)
- Integrin mediated signal transduction in oncogenesis: An overview (1995) (31)
- Paxillin phosphorylation: bifurcation point downstream of integrin‐linked kinase (ILK) in streptococcal invasion (2007) (31)
- Integrin-linked kinase functions as a downstream signal of platelet-derived growth factor to regulate actin polymerization and vascular smooth muscle cell migration (2010) (31)
- Deletion of integrin-linked kinase from skeletal muscles of mice resembles muscular dystrophy due to alpha 7 beta 1-integrin deficiency. (2007) (29)
- Osteoclast‐specific inactivation of the integrin‐linked kinase (ILK) inhibits bone resorption (2010) (29)
- The mitotic functions of integrin-linked kinase (2009) (28)
- Targeting integrin linked kinase and FMS-like tyrosine kinase-3 is cytotoxic to acute myeloid leukemia stem cells but spares normal progenitors. (2010) (28)
- Modulation of the retinoic acid and retinoid X receptor signaling pathways in P19 embryonal carcinoma cells by calreticulin. (1997) (28)
- Integrin-linked kinase (ILK) modulates wound healing through regulation of hepatocyte growth factor (HGF). (2012) (27)
- Cancer Therapeutic Targeting of Hypoxia Induced Carbonic Anhydrase IX: From Bench to Bedside (2022) (27)
- Harnessing Induced Essentiality: Targeting Carbonic Anhydrase IX and Angiogenesis Reduces Lung Metastasis of Triple Negative Breast Cancer Xenografts (2019) (27)
- Interaction of smoothened with integrin‐linked kinase in primary cilia mediates Hedgehog signalling (2013) (26)
- Increased dihydrofolate reductase activity in methotrexate-resistant human promyelocytic-leukaemia (HL-60) cells. Lack of correlation between increased activity and overproduction. (1985) (25)
- Integrin-Linked Kinase Mediates Therapeutic Resistance of Quiescent CML Stem Cells to Tyrosine Kinase Inhibitors. (2020) (24)
- LIMD2 is a small LIM-only protein overexpressed in metastatic lesions that regulates cell motility and tumor progression by directly binding to and activating the integrin-linked kinase. (2014) (23)
- Integrin-linked kinase deletion in the developing lens leads to capsule rupture, impaired fiber migration and non-apoptotic epithelial cell death. (2012) (23)
- Integrin linked kinase (ILK) is required for lens epithelial cell survival, proliferation and differentiation. (2014) (23)
- Inducible Interaction of Integrin α2β1 with Calreticulin (1995) (23)
- Heterogeneity in the specific activity and methotrexate sensitivity of dihydrofolate reductase from blast cells of acute myelogenous leukemia patients. (1985) (22)
- Integrin-linked kinase regulates integrin signaling in human trabecular meshwork cells. (2011) (22)
- Identification of a novel form of the alpha 3 integrin subunit: covalent association with transferrin receptor. (1995) (22)
- Integrin-Linked Kinase Regulates Interphase and Mitotic Microtubule Dynamics (2013) (22)
- Tetraspanin 8 is a novel regulator of ILK-driven β1 integrin adhesion and signaling in invasive melanoma cells (2017) (22)
- f-[18F]fluoroethanol and 3-[18F]fluoropropanol: facile preparation, biodistribution in mice, and their application as nucleophiles in the synthesis of [18F]fluoroalkyl aryl ester and ether PET tracers. (2013) (22)
- Role of epithelial integrin-linked kinase in promoting intestinal inflammation: effects on CCL2, fibronectin and the T cell repertoire (2011) (22)
- Integrin‐linked kinase regulates tubular aquaporin‐2 content and intracellular location: a link between the extracellular matrix and water reabsorption (2014) (21)
- Integrin-Linked Kinase links Dynactin-1/Dynactin-2 with cortical Integrin receptors to orient the mitotic spindle relative to the substratum (2015) (20)
- Integrin-linked kinase (ILK) in combination molecular targeting. (2004) (16)
- An adhesion variant of the MG-63 osteosarcoma cell line displays an osteoblast-like phenotype. (1988) (16)
- Inducible Interaction of Integrin a2b1 with Calreticulin DEPENDENCE ON THE ACTIVATION STATE OF THE INTEGRIN* (1995) (16)
- Signal transduction via the beta 1 integrins is a required intermediate in interleukin-1 beta induction of alkaline phosphatase activity in human osteosarcoma cells. (1989) (16)
- Stimulation of tyrosine phosphorylation of distinct proteins in response to antibody-mediated ligation and clustering of α 3 and α 6 integrins (1995) (16)
- Overproduction of two antigenically distinct forms of dihydrofolate reductase in a highly methotrexate-resistant mouse leukemia cell line. (1983) (16)
- Deep Sequence Analysis of Gene Expression Identifies Osteopontin as a Downstream Effector of Integrin-Linked Kinase (ILK) in Cardiac-Specific ILK Knockout Mice (2013) (15)
- A novel inhibitory effect of oxazol-5-one compounds on ROCKII signaling in human coronary artery vascular smooth muscle cells (2016) (14)
- Specific overproduction of very late antigen 1 integrin in two human neuroblastoma cell lines selected for resistance to detachment by an Arg-Gly-Asp-containing synthetic peptide. (1989) (14)
- Response to Perspectives on the Classical Enzyme Carbonic Anhydrase and the Search for Inhibitors. (2020) (14)
- Properties of a methotrexate-insensitive variant of dihydrofolate reductase derived from methotrexate-resistant L5178Y cells. (1981) (14)
- New mechanisms of regulation of the genomic actions of vitamin D in bone cells: interaction of the vitamin D receptor with non-classical response elements and with the multifunctional protein, calreticulin. (1996) (11)
- Inhibition of a methotrexate-insensitive dihydrofolate reductase from L5178Y cells by substituted triazines and quinazolines. (1983) (10)
- Methotrexate-resistant human promyelocytic leukemia (HL-60) cells express a dihydrofolate reductase with altered properties associated with increased enzyme activity. (1985) (10)
- Interplay of Carbonic Anhydrase IX With Amino Acid and Acid/Base Transporters in the Hypoxic Tumor Microenvironment (2020) (10)
- Integrin-Linked Kinase Is a Functional Mn 2 +-Dependent Protein Kinase that Regulates Glycogen Synthase Kinase-3 b ( GSK-3 b ) Phosphorylation (2010) (10)
- Urokinase-type Plasminogen Activator (uPA) is Inhibited with QLT0267 a Small Molecule Targeting Integrin-linked Kinase (ILK) (2007) (10)
- Identification and characterization of a novel high-molecular-weight form of the integrin α3 subunit (1992) (9)
- Inactivation of the integrin-linked kinase (ILK) in osteoblasts increases mineralization. (2014) (9)
- Ilk conditional deletion in adult animals increases cyclic GMP-dependent vasorelaxation. (2013) (9)
- Evidence that at “high” extracellular methotrexate concentrations the transport barrier is unlikely to be an important mechanism of drug resistance☆ (1982) (9)
- Further studies on substituted quinazolines and triazines as inhibitors of a methotrexate-insensitive murine dihydrofolate reductase. (1986) (8)
- Author Correction: Guidelines and definitions for research on epithelial–mesenchymal transition (2021) (7)
- Carving out its niche: A role for carbonic anhydrase IX in pre-metastatic niche development (2015) (7)
- Insulin attenuates apoptosis in neuronal cells by an integrin-linked kinase-dependent mechanism (2019) (6)
- Integrin-linked kinase: both Jekyll and Hyde in rhabdomyosarcoma. (2009) (6)
- Ablation of beta 1 integrin, focal adhesion kinase and integrin linked kinase in mammary epithelium reveals a critical role for integrin in glandular morphogenesis and differentiation [Abstract] (2005) (6)
- A Model of Differential Mammary Growth Initiation by Stat3 and Asymmetric Integrin-α6 Inheritance. (2020) (6)
- Granulocyte Colony Stimulating Factor Expression in Breast Cancer and Its Association with Carbonic Anhydrase IX and Immune Checkpoints (2021) (6)
- Prognostic value of the PrPC-ILK-IDO1 axis in the mesenchymal colorectal cancer subtype (2021) (6)
- New Perspectives on the Role of Integrin-Linked Kinase (ILK) Signaling in Cancer Metastasis (2022) (4)
- pH regulators of the tumoral microenvironment: A general overview (2021) (4)
- Preliminary communications. (1982) (4)
- Abstract 841: Therapeutic targeting of cancer cells in the hypoxic microenvironment using an orally bioavailable small molecule inhibitor of carbonic anhydrase IX (2014) (4)
- Isolation and characterization of monoclonal antibodies against human carbonic anhydrase-IX (2021) (3)
- Abstract B03: Hypoxia-induced carbonic anhydrase IX promotes MDSC recruitment and establishment of the breast cancer premetastatic niche by stimulating G-CSF production (2015) (3)
- The Role of Integrin-Linked Kinase in Cancer Development and Progression (2010) (3)
- Cancer esearch apeutics , Targets , and Chemical Biology el Matrix Metalloproteinase Inhibitor [ 18 F ] Marimastat-ltrifluoroborate as a Probe for In vivo Positron R ission Tomography Imaging in Cancer (2010) (2)
- Inactivation of the Integrin-Linked Kinase (ILK) in osteoblasts increases mineralization (2008) (2)
- The Effect of Conditional Null Mutation of Integrin-Linked Kinase (Ilk) on Lens Development (2008) (2)
- The Focal Adhesion Complex Ilk-Pinch-Parvin Is Key to Niche Interactions and Survival of Quiescent Stem Cells in Chronic Myeloid Leukemia In Vitro and In Vivo (2016) (2)
- Evaluation of carbonic anhydrase IX as a potential therapeutic target in urothelial carcinoma. (2021) (2)
- 136 Regulation of tumour angiogenesis and cell survival by integrin-linked kinase (ILK): pre-clinical evaluation of novel small molecule inhibitors (2004) (2)
- Stat3 in mitosis: A new role in clustering excess centrosomes (2017) (1)
- Integrin-mediated signal transduction in transgenic mouse models of human breast cancer (2003) (1)
- Hydrogen-deuterium exchange mass spectrometry reveals three unique binding responses of mAbs directed to the catalytic domain of hCAIX (2021) (1)
- Methotrexate resistance in murine and human continuous tumour cell lines: an examination of the different mechanisms involved depending on the order of resistance expressed. (1987) (1)
- Effects of hematopoietic growth factors on nonhematopoietic cells. (1992) (1)
- Conditional Integrin-Linked Kinase Knockout in Epithelial Cells Reveals a Unique Phenotype With Simultaneously Enhanced Proliferation and Apoptosis (2011) (1)
- Identification and characterization of a novel high-molecular-weight form of the integrin alpha 3 subunit. (1992) (1)
- Guidelines and definitions for research on epithelial–mesenchymal transition (2020) (1)
- 2. Survival Impact of HER-2/Neu, Cox-2, Urokinase Plasminogen Activator (upa), Cytokeratin 17/5,6 and other Markers with Long-Term Outcome of Early Breast Cancer. Report from the British Columbia Tissue Micro-Array Project (BCTMAP) (2003) (1)
- Integrin linked kinase is important in platelet signalling and function (2007) (1)
- Syntaxin4-Munc18c Interaction Promotes Breast Tumor Invasion and Metastasis by Regulating MT1-MMP Trafficking (2021) (1)
- Interaction of smoothened with integrin‐linked kinase in primary cilia mediates Hedgehog signalling (2013) (1)
- Divergence in patterns of invasion among subpopulations derived from a human carcinoma clone: roles of intercellular contacts and of cell-substratum adhesion. (1992) (1)
- ILK (integrin-linked kinase) (2017) (1)
- Integrin-Linked Kinase Promotes Colitis Through Regulation of CCL2, Fibronectin and Regulatory T Cells (2011) (1)
- Abstract 324: The integrin-linked kinase (ILK) / Rictor complex is required for TGFβ-1-induced epithelial to mesenchymal transition (EMT) (2012) (1)
- Abstract 3305: The role of carbonic anhydrase IX in tumor hypoxia, metastasis and the cancer stem cell niche (2012) (1)
- LIMD2 is an intracellular activator of Integrin Linked Kinase(ILK) activity and GSK‐3/Akt/beta‐catenin signaling (2018) (1)
- Abstract 3887: A screen for new cancer specific drugs that target centrosome clustering (2012) (1)
- Anastasis, recovery from the brink of death as a mechanism of drug resistance (2021) (1)
- A Carbonic Anhydrase IX/SLC1A5 Axis Regulates Glutamine Metabolism Dependent Ferroptosis in Hypoxic Tumor Cells (2022) (0)
- Subject Index, Vol. 13, 1992 (1992) (0)
- Abstract 455: Hypoxia induced carbonic anhydrase IX is essential for the growth and metastasis of breast tumors (2010) (0)
- EXTH-44. ADDITION OF THE CARBONIC ANHYDRASE IX INHIBITOR SLC-0111 TO TEMOZOLOMIDE EXTENDS SURVIVAL OF MICE BEARING ORTHOTOPIC GLIOBLASTOMAS (2017) (0)
- Abstract 2983: Stat3 regulates supernumerary centrosome clustering in cancer cells via Stathmin/PLK1 (2016) (0)
- Induction of Expression of the arvfll and aVfl3 Integrin Heterodimers during Retinoic Acid-induced Neuronal Differentiation of Murine Embryonal Carcinoma Cells* (2001) (0)
- Abstract 1778: Bacterial regulation of innate and adaptive tumor immunity in metastatic breast cancer (2021) (0)
- Integrin-Linked Kinase As a Key Mediator of Stromal Cell-Enhanced Resistance of Primitive CML Cells to Tyrosine Kinase Inhibitors (2014) (0)
- Supplementary Figure 3 (2010) (0)
- Synthase Kinase 3-Dependent Manner an Integrin-Linked Kinase-and Glycogen Stimulate the AP-1 Transcription Factor in Cell-Extracellular Matrix Interactions (1999) (0)
- Abstract 2989: Integrin-linked kinase regulates mitotic spindle dynamics and its overexpression leads to resistance to paclitaxel-induced cell death (2011) (0)
- Use of the Yeast Two-Hybrid System for the Characterization of Integrin Signal Transduction Pathways: Identification of the Integrin-Linked Kinase, p59ILK (2019) (0)
- Abstract PO-035: Overcoming adaptive resistance to mutant KRAS and MEK inhibitors by co-targeting mTORC1/2 in pancreatic cancer (2020) (0)
- Molecular and Cellular Pathobiology LIMD 2 Is a Small LIM-Only Protein Overexpressed in Metastatic Lesions That Regulates Cell Motility and Tumor Progression by Directly Binding to and Activating the Integrin-Linked Kinase (2014) (0)
- Integrin‐Linked Kinase (ILK) Modulates Coxsackievirus B3‐Induced Myocardial Injury via Protein Kinase B/Akt Activation: A Potential Therapeutic Approach for Entorviral Myocarditis (2006) (0)
- Title Targeting hypoxic response for cancer therapy (2019) (0)
- Abstract 5271: Chemotherapy-induced anastasis as a novel mechanism of therapeutic resistance (2020) (0)
- Profiling the effects of carbonic anhydrase 9/12 inhibition on tumor associated macrophage/microglia polarization in glioma (2018) (0)
- Overexpression of integrin linked kinase (ILK) induces oncogenic transformation and fibronectin matrix assembly in epithelial cells (1997) (0)
- A methotrexate insenitive form of folate reductase present in methotrexate resistant l5178y cells. Abstr. (1979) (0)
- Depletion of Integrin‐Linked Kinase (ILK) from Primary Mouse Hepatocytes Leads to Apoptosis (2006) (0)
- Abstract P038: Identification and functional evaluation of monoclonal antibodies specifically targeting human Carbonic Anhydrase IX (2022) (0)
- Abstract 5897: Tumor-derived bacteria drive breast cancer metastasis (2023) (0)
- Contributors (2021) (0)
- Methotrexate resistance in L5178Y mouse leukemia cells (1982) (0)
- via cAMP signaling pathways PI3-kinase/Akt modulates vascular smooth muscle tone (2015) (0)
- Integrin-linked kinase regulates E-cadherin expression by means of the transcription factor Snail (2001) (0)
- Carbonic Anhydrase IX Interactome and the Regulation of Cancer Progression (2021) (0)
- Abstract CT161: Phase I clinical trials of SLC-0111, a novel inhibitor of carbonic anhydrase IX, in patients with advanced solid tumors (2020) (0)
- Abstract 171: Targeting the tumor microenvironment: inhibition of carbonic anhydrase 9 impedes brain tumor initiating cell chemoresistance and delays glioblastoma growth in vivo (2017) (0)
- Integrin-linked kinase, their inhibitors, and their use for therapeutic treatment method; gene therapy and provision of inhibitors that act as pseudo-substrates (1996) (0)
- Synthesis and evaluation of an 18F-labeled sulfonamide inhibitor for imaging carbonic anhydrase IX expression in cancers (2013) (0)
- Abstract 5997: The role of neutrophil extracellular trap-CCDC25-integrin linked kinase complex in pancreatic cancer progression and metastasis (2022) (0)
- Abstract 754: Targeting carbonic anhydrase IX in multiple pancreatic ductal adenocarcinoma models results in tumor growth inhibition and increased survival (2016) (0)
- A well-trained and well-organised scientific method is what science is (2022) (0)
- SPECT imaging with novel 111In labeled anti-carbonic anhydrase IX monoclonal antibodies: Comparison between internalizing and non-internalizing antibodies (2014) (0)
- EXTH-26. TARGETING BRAIN TUMOR INITIATING CELL CHEMORESISTANCE WITH THE CARBONIC ANHYDRASE IX INHIBITOR SLC-0111 DELAYS GLIOBLASTOMA GROWTH IN VIVO (2016) (0)
- Integrin Linked Kinase (ILK) Modulates the Organization of the Actin Cytoskeleton in Human Trabecular Meshwork (HTM) Cells (2005) (0)
- Isolation of integrin ?-subunit binding cytoplasmic proteins (1990) (0)
- 594 POSTER Combined targeting of mTOR and ILK for maximal suppression of cancer cell growth, Akt activation and cell survival (2006) (0)
- Erratum: Interaction of smoothened with integrin-linked kinase in primary cilia mediates Hedgehog signalling (EMBO Reports (2013) 14 ( 679-682) Doi:10.1038/embor.2013.97) (2013) (0)
- Abstract A047: Tumor-derived bacteria drive breast cancer metastasis (2023) (0)
- Abstract 1002: Perinatal Mortality Following Smooth Muscle Cell-Restricted Deletion of Integrin-Linked Kinase (2006) (0)
- Explorer Molecular dissection of integrin signalling proteins in the control of mammary epithelial development and differentiation (2017) (0)
- Abstract 769: Integrin-Linked Kinase (ILK) breaks Merlin's spell to inhibit the Hippo tumor suppressor pathway and activate the YAP oncogene. (2013) (0)
- Abstract 1906: Combination MEK and mTORC1/2 inhibition overcomes resistance to single agent therapy in pancreatic cancer (2020) (0)
- Studies on the expression of normal and structurally altered dihydrofolate reductase in mouse and human methotrexate-resistant tumour cells (1984) (0)
- 1046 Evaluation of carbonic anhydrase IX as a potential therapeutic target in urothelial carcinoma (2016) (0)
- Epithelial-Mesenchymal Transitions – New Insights into Signaling, Development and Pathogenesis (2007) (0)
- Integrin‐linked kinase KO mice display abnormal liver histology and hepatomegaly following partial hepatectomy (2008) (0)
- Targeting ILK impairs TKI-resistance of quiescent leukemic stem cells in vitro and in vivo (2017) (0)
- The focal adhesion protein ilk is key to niche interactions and survival of CML stem cells (2015) (0)
- QLT0267, a Small Molecule Inhibitor of ILK and FLT3 Is Cytotoxic to Acute Myeloid Leukemia (AML) ‘Stem Cells’ Detected in Immunodeficient Mice. (2008) (0)
- Watch this intracellular space (1993) (0)
- Integrin-Linked Kinase (ilk) is Critical for Stability of the Lens Capsule Extracellular Matrix and for Survival of Lens Epithelial Cells (2010) (0)
- Abstract 992: LIMD2 is a small LIM-only protein overexpressed in metastatic lesions which regulates cell motility and tumor progression by directly binding to and activating the integrin-linked-kinase (2014) (0)
- The role of integrin-linked kinase in the regulation of the Wnt signaling pathway (2004) (0)
- Abstract 2015: Interplay of the pH regulator, carbonic anhydrase IX and the glutamine transporter, ASCT2 in hypoxic tumor microenvironment (2021) (0)
- CALRETICULIN EXPRESSION IN THE POSTNATAL HUMAN BRAIN (1996) (0)
- 61 Mutant-PTEN leads to constitutive integrin-linked kinase (ILK) activity that regulates PKB/Akt activity in glioblastoma cancer cells and targeting ILK results in tumor growth-delay in vivo (2004) (0)
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