Steven E. Shoelson
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(Suggest an Edit or Addition)Steven E. Shoelson's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Type 2 diabetes as an inflammatory disease (2011) (2886)
- SH2 domains recognize specific phosphopeptide sequences (1993) (2618)
- Inflammation and insulin resistance. (2006) (2510)
- Backbone dynamics of a free and phosphopeptide-complexed Src homology 2 domain studied by 15N NMR relaxation. (1994) (1996)
- Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB (2005) (1988)
- Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkβ (2001) (1955)
- Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters (2009) (1846)
- Obesity, inflammation, and insulin resistance. (2007) (1676)
- IKKβ/NF-κB Activation Causes Severe Muscle Wasting in Mice (2004) (1153)
- Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. (2005) (1054)
- Identification of SOCS-3 as a potential mediator of central leptin resistance. (1998) (1029)
- Phosphorylation of Ser307 in Insulin Receptor Substrate-1 Blocks Interactions with the Insulin Receptor and Inhibits Insulin Action* (2002) (959)
- PPARγ is a major driver of the accumulation and phenotype of adipose-tissue Treg cells (2012) (930)
- Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav (1994) (926)
- Phosphatidylinositol 3′‐kinase is activated by association with IRS‐1 during insulin stimulation. (1992) (917)
- SOCS-1 and SOCS-3 Block Insulin Signaling by Ubiquitin-mediated Degradation of IRS1 and IRS2* (2002) (892)
- Crystal Structure of the Tyrosine Phosphatase SHP-2 (1998) (872)
- Prevention of fat-induced insulin resistance by salicylate. (2001) (742)
- IKKbeta/NF-kappaB activation causes severe muscle wasting in mice. (2004) (719)
- Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes. (2002) (692)
- Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: Crystal structures of the complexed and peptide-free forms (1993) (671)
- Recognition of a high-affinity phosphotyrosyl peptide by the Src homology-2 domain of p56lck (1993) (461)
- IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85. (1992) (460)
- Immunometabolism: an emerging frontier (2011) (410)
- A cascade of tyrosine autophosphorylation in the beta-subunit activates the phosphotransferase of the insulin receptor. (1988) (393)
- The Effects of Salsalate on Glycemic Control in Patients With Type 2 Diabetes (2010) (372)
- Phosphoinositide 3-kinase is activated by phosphopeptides that bind to the SH2 domains of the 85-kDa subunit. (1993) (365)
- Metabolic Syndrome, Insulin Resistance, and Roles of Inflammation – Mechanisms and Therapeutic Targets (2012) (352)
- Dileucine‐based sorting signals bind to the β chain of AP‐1 at a site distinct and regulated differently from the tyrosine‐based motif‐binding site (1998) (317)
- Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor. (1993) (298)
- T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif. (1994) (298)
- Structure of the IRS-1 PTB Domain Bound to the Juxtamembrane Region of the Insulin Receptor (1996) (295)
- Inflammation and the IKKβ/IκB/NF-κB axis in obesity- and diet-induced insulin resistance (2003) (290)
- Use of Salsalate to Target Inflammation in the Treatment of Insulin Resistance and Type 2 Diabetes (2008) (281)
- Crystal Structure of the HNF4α Ligand Binding Domain in Complex with Endogenous Fatty Acid Ligand* (2002) (263)
- Potent Stimulation of SH-PTP2 Phosphatase Activity by Simultaneous Occupancy of Both SH2 Domains (*) (1995) (258)
- Identification and characterization of a high-affinity interaction between v-Crk and tyrosine-phosphorylated paxillin in CT10-transformed fibroblasts (1993) (258)
- Structure of the Globular Tail of Nuclear Lamin* (2002) (255)
- Syp (SH-PTP2) is a positive mediator of growth factor-stimulated mitogenic signal transduction. (1994) (241)
- Insulin Resistance Due to Phosphorylation of Insulin Receptor Substrate-1 at Serine 302* (2004) (239)
- Regulatory interactions in the recognition of endocytic sorting signals by AP‐2 complexes (1997) (233)
- The Cbl Phosphotyrosine-binding Domain Selects a D(N/D)XpY Motif and Binds to the Tyr292Negative Regulatory Phosphorylation Site of ZAP-70* (1997) (229)
- Structure of the regulatory domains of the Src-family tyrosine kinase Lck (1994) (228)
- PTB Domains of IRS-1 and Shc Have Distinct but Overlapping Binding Specificities (*) (1995) (225)
- Tandem SH2 Domains Confer High Specificity in Tyrosine Kinase Signaling* (1998) (222)
- Receptor binding redefined by a structural switch in a mutant human insulin (1994) (222)
- Inflammation and the IKK beta/I kappa B/NF-kappa B axis in obesity- and diet-induced insulin resistance. (2003) (218)
- Nuclear magnetic resonance structure of an SH2 domain of phospholipase C-γ1 complexed with a high affinity binding peptide (1994) (217)
- Salicylate (Salsalate) in Patients With Type 2 Diabetes (2013) (215)
- Adipose Natural Killer Cells Regulate Adipose Tissue Macrophages to Promote Insulin Resistance in Obesity. (2016) (214)
- Activation of the SH2-containing protein tyrosine phosphatase, SH-PTP2, by phosphotyrosine-containing peptides derived from insulin receptor substrate-1. (1994) (211)
- Two New Substrates in Insulin Signaling, IRS5/DOK4 and IRS6/DOK5* (2003) (206)
- Crystal Structure of Human Frataxin* (2000) (204)
- The SH3 Domain-binding T Cell Tyrosyl Phosphoprotein p120 (1995) (197)
- Spatial constraints on the recognition of phosphoproteins by the tandem SH2 domains of the phosphatase SH-PTP2 (1996) (193)
- Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase. (1994) (178)
- Interaction of Shc with Grb2 regulates association of Grb2 with mSOS (1995) (178)
- Stimulation through the T Cell Receptor Induces Cbl Association with Crk Proteins and the Guanine Nucleotide Exchange Protein C3G (*) (1996) (177)
- SH2 domains exhibit high-affinity binding to tyrosine-phosphorylated peptides yet also exhibit rapid dissociation and exchange (1993) (173)
- CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells (1995) (172)
- A conserved amino-terminal Shc domain binds to phosphotyrosine motifs in activated receptors and phosphopeptides (1995) (170)
- Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity (2008) (169)
- The Phosphotyrosine Interaction Domain of SHC Recognizes Tyrosine-phosphorylated NPXY Motif (*) (1995) (169)
- T cell antigen CD28 binds to the GRB‐2/SOS complex, regulators of p21ras (1995) (166)
- p120 Is a Major Substrate of Tyrosine Phosphorylation upon B Cell Antigen Receptor Stimulation and Interacts in Vivo with Fyn and Syk Tyrosine Kinases, Grb2 and Shc Adaptors, and the p85 Subunit of Phosphatidylinositol 3-Kinase (*) (1996) (157)
- Nonhydrolyzable phosphotyrosyl mimetics for the preparation of phosphatase-resistant SH2 domain inhibitors. (1994) (156)
- Specific phosphopeptide binding regulates a conformational change in the PI 3‐kinase SH2 domain associated with enzyme activation. (1993) (155)
- Three mutant insulins in man (1983) (146)
- YMXM motifs of IRS-1 define substrate specificity of the insulin receptor kinase. (1992) (145)
- Inflammation and adipose tissue macrophages in lipodystrophic mice (2009) (144)
- Phosphatidylinositol 3-kinase p85 SH2 domain specificity defined by direct phosphopeptide/SH2 domain binding. (1993) (143)
- Association of IRS-1 with the insulin receptor and the phosphatidylinositol 3'-kinase. Formation of binary and ternary signaling complexes in intact cells. (1993) (137)
- Structural basis for IL-4 receptor phosphopeptide recognition by thelRS-1 PTB domain (1996) (136)
- Tryptic activation of the insulin receptor. Proteolytic truncation of the alpha-subunit releases the beta-subunit from inhibitory control. (1988) (132)
- Crystal structure of the PI 3-kinase p85 amino-terminal SH2 domain and its phosphopeptide complexes (1996) (128)
- SH-PTP2/Syp SH2 domain binding specificity is defined by direct interactions with platelet-derived growth factor beta-receptor, epidermal growth factor receptor, and insulin receptor substrate-1-derived phosphopeptides. (1994) (128)
- Therapeutic approaches to target inflammation in type 2 diabetes. (2011) (123)
- Inhibition of SH2 domain/phosphoprotein association by a nonhydrolyzable phosphonopeptide. (1992) (122)
- Regulation of IκB kinase and NF-κB in contracting adult rat skeletal muscle (2005) (121)
- The Role of a Lymphoid-restricted, Grb2-like SH3-SH2-SH3 Protein in T Cell Receptor Signaling* (1997) (116)
- Activated Mutants of SHP-2 Preferentially Induce Elongation of Xenopus Animal Caps (2000) (115)
- Human GRB-IRbeta/GRB10. Splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains. (1997) (114)
- Grb10 Inhibits Insulin-stimulated Insulin Receptor Substrate (IRS)-Phosphatidylinositol 3-Kinase/Akt Signaling Pathway by Disrupting the Association of IRS-1/IRS-2 with the Insulin Receptor* (2003) (114)
- A randomised trial of salsalate for insulin resistance and cardiovascular risk factors in persons with abnormal glucose tolerance (2013) (112)
- Evidence for a role for the phosphotyrosine-binding domain of Shc in interleukin 2 signaling. (1996) (112)
- Correlation between binding and dynamics at SH2 domain interfaces (1998) (111)
- Therapeutic approaches targeting inflammation for diabetes and associated cardiovascular risk. (2017) (110)
- Familial hyperinsulinemia due to a structurally abnormal insulin. Definition of an emerging new clinical syndrome. (1984) (101)
- Getting away from glucose: fanning the flames of obesity-induced inflammation (2009) (100)
- Insulin receptors internalize by a rapid, saturable pathway requiring receptor autophosphorylation and an intact juxtamembrane region (1991) (99)
- SH2 and PTB domain interactions in tyrosine kinase signal transduction. (1997) (97)
- The insulin receptor juxtamembrane region contains two independent tyrosine/beta-turn internalization signals (1992) (96)
- Vascular RAGE transports oxytocin into the brain to elicit its maternal bonding behaviour in mice (2019) (96)
- Specificity of the PTB Domain of Shc for β Turn-forming Pentapeptide Motifs Amino-terminal to Phosphotyrosine (*) (1995) (96)
- T Cell Activation-dependent Association between the p85 Subunit of the Phosphatidylinositol 3-Kinase and Grb2/Phospholipase C-γ1-binding Phosphotyrosyl Protein pp36/38 (*) (1995) (92)
- NMR and photo-CIDNP studies of human proinsulin and prohormone processing intermediates with application to endopeptidase recognition. (1990) (91)
- Kinetics of p56lck and p60src Src homology 2 domain binding to tyrosine-phosphorylated peptides determined by a competition assay or surface plasmon resonance. (1993) (91)
- The insulin receptor and its substrate: molecular determinants of early events in insulin action. (1993) (90)
- Evidence for a Physical Association between the Shc-PTB Domain and the βc Chain of the Granulocyte-Macrophage Colony-stimulating Factor Receptor (*) (1996) (87)
- Crystal structure of the pleckstrin homology-phosphotyrosine binding (PH-PTB) targeting region of insulin receptor substrate 1. (1999) (86)
- 4'-O-[2-(2-fluoromalonyl)]-L-tyrosine: a phosphotyrosyl mimic for the preparation of signal transduction inhibitory peptides. (1996) (84)
- Preferential cleavage of des-31,32-proinsulin over intact proinsulin by the insulin secretory granule type II endopeptidase. Implication of a favored route for prohormone processing. (1992) (83)
- Diabetes mutations delineate an atypical POU domain in HNF-1alpha. (2002) (82)
- Tag Polymorphisms at the A20 (TNFAIP3) Locus Are Associated With Lower Gene Expression and Increased Risk of Coronary Artery Disease in Type 2 Diabetes (2007) (81)
- Heteronuclear 2D NMR studies of an engineered insulin monomer: assignment and characterization of the receptor-binding surface by selective 2H and 13C labeling with application to protein design. (1991) (80)
- NF-κB activation is required for the transition of pulmonary inflammation to muscle atrophy. (2012) (80)
- Expression, purification, and characterization of SH2-containing protein tyrosine phosphatase, SH-PTP2. (1993) (78)
- Biochemical and clinical implications of proinsulin conversion intermediates. (1985) (77)
- Characterization of Insulin Autoantibodies in Relatives of Patients With Type I Diabetes (1993) (75)
- Two-dimensional NMR and photo-CIDNP studies of the insulin monomer: assignment of aromatic resonances with application to protein folding, structure, and dynamics. (1989) (72)
- Structural Basis for HNF-4α Activation by Ligand and Coactivator Binding* (2004) (72)
- Rapid T-cell receptor-mediated tyrosine phosphorylation of p120, an Fyn/Lck Src homology 3 domain-binding protein. (1994) (72)
- Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins (1998) (71)
- Cathepsins in human obesity: changes in energy balance predominantly affect cathepsin s in adipose tissue and in circulation. (2010) (70)
- Kinase Activation through Dimerization by Human SH2-B (2005) (69)
- Mutations at the dimer, hexamer, and receptor-binding surfaces of insulin independently affect insulin-insulin and insulin-receptor interactions. (1992) (67)
- Insulin-stimulated oocyte maturation requires insulin receptor substrate 1 and interaction with the SH2 domains of phosphatidylinositol 3-kinase (1993) (66)
- Identification of a mutant human insulin predicted to contain a serine-for-phenylalanine substitution. (1983) (64)
- Lipocortins 1 and 2 as substrates for the insulin receptor kinase in rat liver. (1988) (64)
- Conformationally constrained phosphotyrosyl mimetics designed as monomeric Src homology 2 domain inhibitors. (1995) (64)
- Plasma somatostatin 28 increases in response to feeding in man. (1983) (63)
- Physical and functional interactions between SH2 and SH3 domains of the Src family protein tyrosine kinase p59fyn (1994) (61)
- Role of IGF-I and the TNFα/NF-κB pathway in the induction of muscle atrogenes by acute inflammation. (2012) (61)
- L-O-(2-malonyl)tyrosine: a new phosphotyrosyl mimetic for the preparation of Src homology 2 domain inhibitory peptides. (1995) (57)
- Tyrosine-phosphorylated Cbl binds to Crk after T cell activation. (1996) (57)
- Polyoma virus middle T antigen-pp60c-src complex associates with purified phosphatidylinositol 3-kinase in vitro. (1992) (57)
- Insulin receptor autophosphorylation occurs asymmetrically. (1993) (56)
- Conformational changes of the insulin receptor upon insulin binding and activation as monitored by fluorescence spectroscopy. (1997) (55)
- Phosphorylation of synthetic peptides containing Tyr-Met-X-Met motifs by nonreceptor tyrosine kinases in vitro. (1993) (55)
- A phenylalanine zipper mediates APS dimerization (2004) (54)
- Age-associated NF-κB signaling in myofibers alters the satellite cell niche and re-strains muscle stem cell function (2016) (54)
- Familial hyperproinsulinemia. Two cohorts secreting indistinguishable type II intermediates of proinsulin conversion. (1984) (53)
- BpaB25 insulins. Photoactivatable analogues that quantitatively cross-link, radiolabel, and activate the insulin receptor. (1993) (52)
- Regulation of IkappaB kinase and NF-kappaB in contracting adult rat skeletal muscle. (2005) (51)
- Targeting Inflammation Using Salsalate in Patients With Type 2 Diabetes: Effects on Flow-Mediated Dilation (TINSAL-FMD) (2013) (50)
- A Radioimmunoassay for Circulating Human Proinsulin (1985) (50)
- Insulin Receptor Activation with Transmembrane Domain Ligands* (2014) (47)
- Substitution of the erbB-2 oncoprotein transmembrane domain activates the insulin receptor and modulates the action of insulin and insulin-receptor substrate 1. (1993) (46)
- Identification of residues in the beta platelet-derived growth factor receptor that confer specificity for binding to phospholipase C-gamma 1. (1993) (46)
- Human insulin B24 (Phe----Ser). Secretion and metabolic clearance of the abnormal insulin in man and in a dog model. (1984) (45)
- Effect of Targeting Inflammation With Salsalate: The TINSAL-CVD Randomized Clinical Trial on Progression of Coronary Plaque in Overweight and Obese Patients Using Statins. (2016) (45)
- Functional Roles of the Shc Phosphotyrosine Binding and Src Homology 2 Domains in Insulin and Epidermal Growth Factor Signaling* (1996) (43)
- NF-κB activation and polyubiquitin conjugation are required for pulmonary inflammation-induced diaphragm atrophy. (2012) (41)
- Hepatocyte-specific IKKβ expression aggravates atherosclerosis development in APOE*3-Leiden mice. (2012) (40)
- Retinal not systemic oxidative and inflammatory stress correlated with VEGF expression in rodent models of insulin resistance and diabetes. (2012) (40)
- Substitution of the insulin receptor transmembrane domain with the c-neu/erbB2 transmembrane domain constitutively activates the insulin receptor kinase in vitro. (1992) (39)
- A photoaffinity scan maps regions of the p85 SH2 domain involved in phosphoprotein binding. (1993) (36)
- Nonphosphorylatable substrate analogs selectively block autophosphorylation and activation of the insulin receptor, epidermal growth factor receptor, and pp60v-src kinases. (1989) (36)
- Paradoxical structure and function in a mutant human insulin associated with diabetes mellitus. (1993) (35)
- The phosphopeptide-binding specificity of Src family SH2 domains. (1994) (33)
- Expansion and contraction: treating diabetes with bariatric surgery (2009) (31)
- JMM – Past and Present (2002) (31)
- Solid-phase synthesis of nonhydrolyzable phosphotyrosyl peptide analogues with Nα-Fmoc-(O,O-di-t-butyl)phosphono-p-methylphenylalanine (1991) (31)
- Optimizing transmembrane domain helicity accelerates insulin receptor internalization and lateral mobility. (1993) (31)
- Cellular effects of phosphotyrosine-binding domain inhibitors on insulin receptor signaling and trafficking (1997) (31)
- Insulin differentially regulates protein phosphotyrosine phosphatase activity in rat hepatoma cells. (1992) (31)
- Antiinsulin receptor antibodies in an insulin-dependent diabetic may arise as autoantiidiotypes. (1986) (30)
- Binding of a High Affinity Phosphotyrosyl Peptide to the Src SH 2 Domain : Crystal Structures of the Complexed and Peptide (2004) (29)
- Aspirin reduces hypertriglyceridemia by lowering VLDL-triglyceride production in mice fed a high-fat diet. (2011) (29)
- The Impact of Salsalate Treatment on Serum Levels of Advanced Glycation End Products in Type 2 Diabetes (2014) (29)
- Shf, a Shb-like Adapter Protein, Is Involved in PDGF-α-Receptor Regulation of Apoptosis (2000) (28)
- Role of the Transmembrane Domain and Flanking Amino Acids in Internalization and Down-regulation of the Insulin Receptor * (1995) (28)
- Autophosphorylation within insulin receptor beta-subunits can occur as an intramolecular process. (1991) (28)
- Banking on ATM as a new target in metabolic syndrome. (2006) (28)
- Functional Characterization of Obesity-Associated Variants Involving the α and β Isoforms of Human SH2B1 (2014) (28)
- Crystal Structures of Human TBC1D1 and TBC1D4 (AS160) RabGTPase-activating Protein (RabGAP) Domains Reveal Critical Elements for GLUT4 Translocation* (2011) (27)
- Multiple Binding Modes between HNF4α and the LXXLL Motifs of PGC-1α Lead to Full Activation* (2009) (26)
- Hepatocyte-specific IKK-β activation enhances VLDL-triglyceride production in APOE*3-Leiden mice[S] (2011) (25)
- Identification and functional characterization of a novel mutation of hepatocyte nuclear factor-1α gene in a Korean family with MODY3 (2003) (24)
- Profilin-1 Haploinsufficiency Protects Against Obesity-Associated Glucose Intolerance and Preserves Adipose Tissue Immune Homeostasis (2013) (24)
- Interaction of Shc with Grb2 Regulates the Grb2 Association with mSOS (1995) (23)
- Possible v-Crk-induced Transformation through Activation of Src Kinases (*) (1995) (23)
- Nonlocal structural perturbations in a mutant human insulin: sequential resonance assignment and 13C-isotope-aided 2D-NMR studies of [PheB24-->Gly]insulin with implications for receptor recognition. (1992) (22)
- Cathepsins in Human Obesity: Changes in Energy Balance Predominantly Affect Cathepsin S in Adipose Tissue and in Circulation (2010) (22)
- Muscle-Specific Inhibition of the Classical Nuclear Factor-&kgr;B Pathway Is Protective Against Diaphragmatic Weakness in Murine Endotoxemia (2014) (21)
- Regulation of Diet-Induced Adipose Tissue and Systemic Inflammation by Salicylates and Pioglitazone (2013) (21)
- Evidence for the Presence of Somatostatin 28 in Plasma (1982) (21)
- DIABETES MUTATIONS DELINEATE AN ATYPICAL POU DOMAIN IN HNF1A. (2002) (20)
- Sustained NFκB inhibition improves insulin sensitivity but is detrimental to muscle health (2017) (20)
- Inflammation and obesity: STAMPing out insulin resistance? (2007) (20)
- Circulating forms of somatostatinlike immunoreactivity in human plasma. (1986) (20)
- Products of Therapeutic Insulins in the Blood of Insulin-dependent (Type I) Diabetic Patients (1985) (19)
- Cooperative self-assembly of SH2 domain fragments restores phosphopeptide binding. (1993) (18)
- Shf, a Shb-like adapter protein, is involved in PDGF-alpha-receptor regulation of apoptosis. (2000) (15)
- Salsalate improves glycaemia in overweight persons with diabetes risk factors of stable statin‐treated cardiovascular disease: A 30‐month randomized placebo‐controlled trial (2017) (15)
- Cyclic peptide inhibitors of phosphatidylinositol 3-kinase p85 SH2 domain binding. (1994) (15)
- Transmembrane domain inversion blocks ER release and insulin receptor signaling. (1995) (13)
- Fat T reg cells : a liaison between the immune and metabolic systems (2011) (13)
- X-ray Crystallographic Structure of TIR-Domain from the Human TIR-Domain Containing Adaptor Protein/MyD88 Adaptor-Like Protein (TIRAP/MAL) (2012) (12)
- High-performance liquid chromatography (HPLC): A rapid, flexible and sensitive method for separating islet proinsulin and insulin (1986) (11)
- An irregularity in the transmembrane domain helix correlates with the rate of insulin receptor internalization. (1994) (11)
- Invited comment on W. Ebstein: On the therapy of diabetes mellitus, in particular on the application of sodium salicylate (2002) (10)
- Functional characterisation of obesity-associated variants involving the alpha and beta isoforms of human SH 2 B 1 (2014) (10)
- Phosphopeptide occupancy and photoaffinity cross-linking of the v-Src SH2 domain attenuates tyrosine kinase activity. (1994) (10)
- Sustained NF-κB Activation and Inhibition in β-Cells Have Minimal Effects on Function and Islet Transplant Outcomes (2013) (10)
- Norleucine as a replacement for methionine in phosphatase-resistant linear and cyclic peptides which bind to p85 SH2 domains (1994) (8)
- Symposium III: Biomarkers of Acute Kidney Injury: Early Diagnosis, Pathogenesis, and Recovery (2007) (8)
- NFκB Regulates Muscle Development and Mitochondrial Function. (2018) (8)
- TYROSINE PHOSPHATASE SHP-2 (1999) (7)
- Effects of the anti-inflammatory drug salsalate on bone turnover in type 2 diabetes mellitus (2015) (6)
- Externalized phosphatidylinositides on apoptotic cells are eat-me signals recognized by CD14 (2022) (6)
- The carboxy-terminal region of the TBC1D4 (AS160) RabGAP mediates protein homodimerization. (2017) (6)
- Response to Comment on Goldfine et al. Targeting Inflammation Using Salsalate in Patients With Type 2 Diabetes: Effects on Flow-Mediated Dilation (TINSAL-FMD). Diabetes Care 2013;36:4132–4139 (2014) (5)
- Intermolecular Phosphorylation between Insulin Holoreceptors Does Not Stimulate Substrate Kinase Activity (*) (1995) (4)
- Glu-mediated dimerization of the transmembrane region of the oncogenic neu protein (1994) (4)
- When a domain is not a domain (2008) (4)
- Synthesis and structure-activity studies of SH2 binding peptides containing hydrolytically stable analogs of O -phosphotyrosine (1994) (3)
- Structure of the Globular Tail of (2002) (3)
- Human GRB-IRβ/GRB10 (1997) (3)
- Insulin and Other Antidiabetic Agents (2009) (3)
- Genetic variability in insulin action inhibitor Ikkbeta (IKBKB) does not play a major role in the development of type 2 diabetes. (2002) (2)
- RabGTPase-activating Protein ( RabGAP ) Domains Reveal Critical Elements for GLUT 4 Translocation * (2011) (2)
- COMMENT: Genetic Variability in Insulin Action Inhibitor Ikkβ (IKBKB) Does Not Play a Major Role in the Development of Type 2 Diabetes (2002) (2)
- Fat-Specific Expression of Activated IKKβ Causes Insulin Resistance in Mice (2002) (2)
- Socs1 Induces Insulin Resistance by Promoting Ubiquitin-Mediated Degradation of IRS1 and IRS2 (2002) (2)
- Synthesis and structure activity studies of phosphatase resistant SH2 domain inhibiting peptides: D-amino acid effects (1995) (1)
- SYMPOSIUM III (2007) (1)
- association of Grb2 with mSOS. Interaction of Shc with Grb2 regulates (2013) (0)
- IRS PROTEIN STRUCTURE (2002) (0)
- Crystal structure of the PI3-kinase p85 N-terminal SH2 domain in complex with c-Kit phosphotyrosyl peptide (2006) (0)
- Crystal structure of the PI3-kinase p85 N-terminal SH2 domain in complex with PDGFR phosphotyrosyl peptide (2006) (0)
- HEPATOCYTE NUCLEAR FACTOR 1A BOUND TO DNA : MODY3 GENE PRODUCT (2002) (0)
- A photoaffinity scan maps regions of an SH2 domain involved in phosphoprotein interactions (1994) (0)
- P408 LIVER-SPECIFIC IKK-β ACTIVATION SEVERELY AGGRAVATES ATHEROSCLEROSIS DEVELOPMENT IN APOE*3-LEIDEN MICE (2010) (0)
- TargetingInflammationUsingSalsalatein Patients With Type 2 Diabetes: Effects on Flow-Mediated Dilation (TINSAL-FMD). Diabetes Care 2013;36:4132-4139 (2014) (0)
- Abstract: P700 CHRONIC HEPATIC INFLAMMATION SEVERELY AGGRAVATES ATHEROSCLEROSIS DEVELOPMENT (2009) (0)
- Hepatocyte-specific inflammation enhances VLDL production in mice (2008) (0)
- Use of a Monomeric Insulin Template for Studying Structural Effects of Substitutions within Insulin's Receptor-Binding Surface, (1992) (0)
- An Anti-Inflammatory Approach to Treating Diabetes and Atherosclerosis Using Salicylate (2014) (0)
- Crystal structure of the PI3-kinase p85 N-terminal SH2 domain (2006) (0)
- 3 ASPIRIN REDUCES HYPERTRIGLYCERIDEMIA BY LOWERING VLDL-TRIGLYCERIDE PRODUCTION IN MICE FED A HIGH-FAT DIET (2013) (0)
- Vascular RAGE transports oxytocin into the brain to elicit its maternal bonding behaviour in mice (2019) (0)
- OP031 ROLE OF IGF-I AND TNF-ALPHA/NF-KAPPA B PATHWAY IN THE INDUCTION OF THE TRANSCRIPTIONAL MUSCLE ATROPHY PROGRAM BY ACUTE INFLAMMATION (2012) (0)
- Responses of somatostatin components to oral glucose in human plasma. (1983) (0)
- Crystal Structure of Human TBC1D1 RabGAP domain (2011) (0)
- Determinants of specificity in phosphoprotein/ SH2 domain interactions (1994) (0)
- Specific Activation of the Insulin Receptor by the Transmembrane Domain Peptides (2001) (0)
- Comparative 2D NMR studies of the Phe B24 → Leu mutant human insulin (1988) (0)
- Effects Of Muscle-Specific Inhibition Of The NF-kB Pathway On Diaphragmatic Function In Murine Sepsis (2010) (0)
- Physical and Functional Interactions between SH 2 and SH 3 Domains of the Src Family Protein Tyrosine Kinase p 59 fi 5 (0)
- Adenovirus-Mediated Expression of Activated IKKβ or Inhibitory IκB Causes Insulin Resistance or Reverses It, Respectively, in Mice (2002) (0)
- Blood glucose levels in STZ diabetic male C57BL/6AF1 mice transplanted with 150 fresh islets with administration of salicylate in the water (closed triangles) or regular water (open triangles). (2013) (0)
- Bpa-Insulins: Photoactivatable Analogs for Identifying Site-Site Interactions Between Insulin and the Insulin Receptor, (1992) (0)
- CRYSTAL STRUCTURE OF THE PH-PTB TARGETING REGION OF IRS-1 (1999) (0)
- MATURE HUMAN FRATAXIN (2000) (0)
- Crystal structure of HNF4a LBD in complex with the ligand and the coactivator SRC-1 peptide (2004) (0)
- Hepatocyte-specific Inflammation Directly Enhances VLDL-triglyceride Production in Mice (2010) (0)
- Point-counterpoint: Interleukin-6 does/does not have a beneficial role in insulin sensitivity and glucose homeostasis. (2007) (0)
- HNF4a ligand binding domain with bound fatty acid (2003) (0)
- Phosphatase-resistant SH2 domain inhibitors (1994) (0)
- Structure of Lamin A/C Globular Domain (2002) (0)
- NFκB Regulation of Mitochondrial Function in Skeletal and Cardiac Muscle (2018) (0)
- insulin sensitivity and glucose homeostasis Interleukin-6 does/does not have a beneficial role in (2007) (0)
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What Schools Are Affiliated With Steven E. Shoelson?
Steven E. Shoelson is affiliated with the following schools: