Steven E. Shoelson

Steven E. Shoelson's AcademicInfluence.com Rankings

Steven E. Shoelson

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Philosophy

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Steven E. Shoelson's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Type 2 diabetes as an inflammatory disease (2011) (2886)
SH2 domains recognize specific phosphopeptide sequences (1993) (2618)
Inflammation and insulin resistance. (2006) (2510)
Backbone dynamics of a free and phosphopeptide-complexed Src homology 2 domain studied by 15N NMR relaxation. (1994) (1996)
Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB (2005) (1988)
Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkβ (2001) (1955)
Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters (2009) (1846)
Obesity, inflammation, and insulin resistance. (2007) (1676)
IKKβ/NF-κB Activation Causes Severe Muscle Wasting in Mice (2004) (1153)
Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. (2005) (1054)
Identification of SOCS-3 as a potential mediator of central leptin resistance. (1998) (1029)
Phosphorylation of Ser307 in Insulin Receptor Substrate-1 Blocks Interactions with the Insulin Receptor and Inhibits Insulin Action* (2002) (959)
PPARγ is a major driver of the accumulation and phenotype of adipose-tissue Treg cells (2012) (930)
Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav (1994) (926)
Phosphatidylinositol 3′‐kinase is activated by association with IRS‐1 during insulin stimulation. (1992) (917)
SOCS-1 and SOCS-3 Block Insulin Signaling by Ubiquitin-mediated Degradation of IRS1 and IRS2* (2002) (892)
Crystal Structure of the Tyrosine Phosphatase SHP-2 (1998) (872)
Prevention of fat-induced insulin resistance by salicylate. (2001) (742)
IKKbeta/NF-kappaB activation causes severe muscle wasting in mice. (2004) (719)
Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes. (2002) (692)
Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: Crystal structures of the complexed and peptide-free forms (1993) (671)
Recognition of a high-affinity phosphotyrosyl peptide by the Src homology-2 domain of p56lck (1993) (461)
IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85. (1992) (460)
Immunometabolism: an emerging frontier (2011) (410)
A cascade of tyrosine autophosphorylation in the beta-subunit activates the phosphotransferase of the insulin receptor. (1988) (393)
The Effects of Salsalate on Glycemic Control in Patients With Type 2 Diabetes (2010) (372)
Phosphoinositide 3-kinase is activated by phosphopeptides that bind to the SH2 domains of the 85-kDa subunit. (1993) (365)
Metabolic Syndrome, Insulin Resistance, and Roles of Inflammation – Mechanisms and Therapeutic Targets (2012) (352)
Dileucine‐based sorting signals bind to the β chain of AP‐1 at a site distinct and regulated differently from the tyrosine‐based motif‐binding site (1998) (317)
Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor. (1993) (298)
T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif. (1994) (298)
Structure of the IRS-1 PTB Domain Bound to the Juxtamembrane Region of the Insulin Receptor (1996) (295)
Inflammation and the IKKβ/IκB/NF-κB axis in obesity- and diet-induced insulin resistance (2003) (290)
Use of Salsalate to Target Inflammation in the Treatment of Insulin Resistance and Type 2 Diabetes (2008) (281)
Crystal Structure of the HNF4α Ligand Binding Domain in Complex with Endogenous Fatty Acid Ligand* (2002) (263)
Potent Stimulation of SH-PTP2 Phosphatase Activity by Simultaneous Occupancy of Both SH2 Domains (*) (1995) (258)
Identification and characterization of a high-affinity interaction between v-Crk and tyrosine-phosphorylated paxillin in CT10-transformed fibroblasts (1993) (258)
Structure of the Globular Tail of Nuclear Lamin* (2002) (255)
Syp (SH-PTP2) is a positive mediator of growth factor-stimulated mitogenic signal transduction. (1994) (241)
Insulin Resistance Due to Phosphorylation of Insulin Receptor Substrate-1 at Serine 302* (2004) (239)
Regulatory interactions in the recognition of endocytic sorting signals by AP‐2 complexes (1997) (233)
The Cbl Phosphotyrosine-binding Domain Selects a D(N/D)XpY Motif and Binds to the Tyr292Negative Regulatory Phosphorylation Site of ZAP-70* (1997) (229)
Structure of the regulatory domains of the Src-family tyrosine kinase Lck (1994) (228)
PTB Domains of IRS-1 and Shc Have Distinct but Overlapping Binding Specificities (*) (1995) (225)
Tandem SH2 Domains Confer High Specificity in Tyrosine Kinase Signaling* (1998) (222)
Receptor binding redefined by a structural switch in a mutant human insulin (1994) (222)
Inflammation and the IKK beta/I kappa B/NF-kappa B axis in obesity- and diet-induced insulin resistance. (2003) (218)
Nuclear magnetic resonance structure of an SH2 domain of phospholipase C-γ1 complexed with a high affinity binding peptide (1994) (217)
Salicylate (Salsalate) in Patients With Type 2 Diabetes (2013) (215)
Adipose Natural Killer Cells Regulate Adipose Tissue Macrophages to Promote Insulin Resistance in Obesity. (2016) (214)
Activation of the SH2-containing protein tyrosine phosphatase, SH-PTP2, by phosphotyrosine-containing peptides derived from insulin receptor substrate-1. (1994) (211)
Two New Substrates in Insulin Signaling, IRS5/DOK4 and IRS6/DOK5* (2003) (206)
Crystal Structure of Human Frataxin* (2000) (204)
The SH3 Domain-binding T Cell Tyrosyl Phosphoprotein p120 (1995) (197)
Spatial constraints on the recognition of phosphoproteins by the tandem SH2 domains of the phosphatase SH-PTP2 (1996) (193)
Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase. (1994) (178)
Interaction of Shc with Grb2 regulates association of Grb2 with mSOS (1995) (178)
Stimulation through the T Cell Receptor Induces Cbl Association with Crk Proteins and the Guanine Nucleotide Exchange Protein C3G (*) (1996) (177)
SH2 domains exhibit high-affinity binding to tyrosine-phosphorylated peptides yet also exhibit rapid dissociation and exchange (1993) (173)
CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells (1995) (172)
A conserved amino-terminal Shc domain binds to phosphotyrosine motifs in activated receptors and phosphopeptides (1995) (170)
Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity (2008) (169)
The Phosphotyrosine Interaction Domain of SHC Recognizes Tyrosine-phosphorylated NPXY Motif (*) (1995) (169)
T cell antigen CD28 binds to the GRB‐2/SOS complex, regulators of p21ras (1995) (166)
p120 Is a Major Substrate of Tyrosine Phosphorylation upon B Cell Antigen Receptor Stimulation and Interacts in Vivo with Fyn and Syk Tyrosine Kinases, Grb2 and Shc Adaptors, and the p85 Subunit of Phosphatidylinositol 3-Kinase (*) (1996) (157)
Nonhydrolyzable phosphotyrosyl mimetics for the preparation of phosphatase-resistant SH2 domain inhibitors. (1994) (156)
Specific phosphopeptide binding regulates a conformational change in the PI 3‐kinase SH2 domain associated with enzyme activation. (1993) (155)
Three mutant insulins in man (1983) (146)
YMXM motifs of IRS-1 define substrate specificity of the insulin receptor kinase. (1992) (145)
Inflammation and adipose tissue macrophages in lipodystrophic mice (2009) (144)
Phosphatidylinositol 3-kinase p85 SH2 domain specificity defined by direct phosphopeptide/SH2 domain binding. (1993) (143)
Association of IRS-1 with the insulin receptor and the phosphatidylinositol 3'-kinase. Formation of binary and ternary signaling complexes in intact cells. (1993) (137)
Structural basis for IL-4 receptor phosphopeptide recognition by thelRS-1 PTB domain (1996) (136)
Tryptic activation of the insulin receptor. Proteolytic truncation of the alpha-subunit releases the beta-subunit from inhibitory control. (1988) (132)
Crystal structure of the PI 3-kinase p85 amino-terminal SH2 domain and its phosphopeptide complexes (1996) (128)
SH-PTP2/Syp SH2 domain binding specificity is defined by direct interactions with platelet-derived growth factor beta-receptor, epidermal growth factor receptor, and insulin receptor substrate-1-derived phosphopeptides. (1994) (128)
Therapeutic approaches to target inflammation in type 2 diabetes. (2011) (123)
Inhibition of SH2 domain/phosphoprotein association by a nonhydrolyzable phosphonopeptide. (1992) (122)
Regulation of IκB kinase and NF-κB in contracting adult rat skeletal muscle (2005) (121)
The Role of a Lymphoid-restricted, Grb2-like SH3-SH2-SH3 Protein in T Cell Receptor Signaling* (1997) (116)
Activated Mutants of SHP-2 Preferentially Induce Elongation of Xenopus Animal Caps (2000) (115)
Human GRB-IRbeta/GRB10. Splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains. (1997) (114)
Grb10 Inhibits Insulin-stimulated Insulin Receptor Substrate (IRS)-Phosphatidylinositol 3-Kinase/Akt Signaling Pathway by Disrupting the Association of IRS-1/IRS-2 with the Insulin Receptor* (2003) (114)
A randomised trial of salsalate for insulin resistance and cardiovascular risk factors in persons with abnormal glucose tolerance (2013) (112)
Evidence for a role for the phosphotyrosine-binding domain of Shc in interleukin 2 signaling. (1996) (112)
Correlation between binding and dynamics at SH2 domain interfaces (1998) (111)
Therapeutic approaches targeting inflammation for diabetes and associated cardiovascular risk. (2017) (110)
Familial hyperinsulinemia due to a structurally abnormal insulin. Definition of an emerging new clinical syndrome. (1984) (101)
Getting away from glucose: fanning the flames of obesity-induced inflammation (2009) (100)
Insulin receptors internalize by a rapid, saturable pathway requiring receptor autophosphorylation and an intact juxtamembrane region (1991) (99)
SH2 and PTB domain interactions in tyrosine kinase signal transduction. (1997) (97)
The insulin receptor juxtamembrane region contains two independent tyrosine/beta-turn internalization signals (1992) (96)
Vascular RAGE transports oxytocin into the brain to elicit its maternal bonding behaviour in mice (2019) (96)
Specificity of the PTB Domain of Shc for β Turn-forming Pentapeptide Motifs Amino-terminal to Phosphotyrosine (*) (1995) (96)
T Cell Activation-dependent Association between the p85 Subunit of the Phosphatidylinositol 3-Kinase and Grb2/Phospholipase C-γ1-binding Phosphotyrosyl Protein pp36/38 (*) (1995) (92)
NMR and photo-CIDNP studies of human proinsulin and prohormone processing intermediates with application to endopeptidase recognition. (1990) (91)
Kinetics of p56lck and p60src Src homology 2 domain binding to tyrosine-phosphorylated peptides determined by a competition assay or surface plasmon resonance. (1993) (91)
The insulin receptor and its substrate: molecular determinants of early events in insulin action. (1993) (90)
Evidence for a Physical Association between the Shc-PTB Domain and the βc Chain of the Granulocyte-Macrophage Colony-stimulating Factor Receptor (*) (1996) (87)
Crystal structure of the pleckstrin homology-phosphotyrosine binding (PH-PTB) targeting region of insulin receptor substrate 1. (1999) (86)
4'-O-[2-(2-fluoromalonyl)]-L-tyrosine: a phosphotyrosyl mimic for the preparation of signal transduction inhibitory peptides. (1996) (84)
Preferential cleavage of des-31,32-proinsulin over intact proinsulin by the insulin secretory granule type II endopeptidase. Implication of a favored route for prohormone processing. (1992) (83)
Diabetes mutations delineate an atypical POU domain in HNF-1alpha. (2002) (82)
Tag Polymorphisms at the A20 (TNFAIP3) Locus Are Associated With Lower Gene Expression and Increased Risk of Coronary Artery Disease in Type 2 Diabetes (2007) (81)
Heteronuclear 2D NMR studies of an engineered insulin monomer: assignment and characterization of the receptor-binding surface by selective 2H and 13C labeling with application to protein design. (1991) (80)
NF-κB activation is required for the transition of pulmonary inflammation to muscle atrophy. (2012) (80)
Expression, purification, and characterization of SH2-containing protein tyrosine phosphatase, SH-PTP2. (1993) (78)
Biochemical and clinical implications of proinsulin conversion intermediates. (1985) (77)
Characterization of Insulin Autoantibodies in Relatives of Patients With Type I Diabetes (1993) (75)
Two-dimensional NMR and photo-CIDNP studies of the insulin monomer: assignment of aromatic resonances with application to protein folding, structure, and dynamics. (1989) (72)
Structural Basis for HNF-4α Activation by Ligand and Coactivator Binding* (2004) (72)
Rapid T-cell receptor-mediated tyrosine phosphorylation of p120, an Fyn/Lck Src homology 3 domain-binding protein. (1994) (72)
Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins (1998) (71)
Cathepsins in human obesity: changes in energy balance predominantly affect cathepsin s in adipose tissue and in circulation. (2010) (70)
Kinase Activation through Dimerization by Human SH2-B (2005) (69)
Mutations at the dimer, hexamer, and receptor-binding surfaces of insulin independently affect insulin-insulin and insulin-receptor interactions. (1992) (67)
Insulin-stimulated oocyte maturation requires insulin receptor substrate 1 and interaction with the SH2 domains of phosphatidylinositol 3-kinase (1993) (66)
Identification of a mutant human insulin predicted to contain a serine-for-phenylalanine substitution. (1983) (64)
Lipocortins 1 and 2 as substrates for the insulin receptor kinase in rat liver. (1988) (64)
Conformationally constrained phosphotyrosyl mimetics designed as monomeric Src homology 2 domain inhibitors. (1995) (64)
Plasma somatostatin 28 increases in response to feeding in man. (1983) (63)
Physical and functional interactions between SH2 and SH3 domains of the Src family protein tyrosine kinase p59fyn (1994) (61)
Role of IGF-I and the TNFα/NF-κB pathway in the induction of muscle atrogenes by acute inflammation. (2012) (61)
L-O-(2-malonyl)tyrosine: a new phosphotyrosyl mimetic for the preparation of Src homology 2 domain inhibitory peptides. (1995) (57)
Tyrosine-phosphorylated Cbl binds to Crk after T cell activation. (1996) (57)
Polyoma virus middle T antigen-pp60c-src complex associates with purified phosphatidylinositol 3-kinase in vitro. (1992) (57)
Insulin receptor autophosphorylation occurs asymmetrically. (1993) (56)
Conformational changes of the insulin receptor upon insulin binding and activation as monitored by fluorescence spectroscopy. (1997) (55)
Phosphorylation of synthetic peptides containing Tyr-Met-X-Met motifs by nonreceptor tyrosine kinases in vitro. (1993) (55)
A phenylalanine zipper mediates APS dimerization (2004) (54)
Age-associated NF-κB signaling in myofibers alters the satellite cell niche and re-strains muscle stem cell function (2016) (54)
Familial hyperproinsulinemia. Two cohorts secreting indistinguishable type II intermediates of proinsulin conversion. (1984) (53)
BpaB25 insulins. Photoactivatable analogues that quantitatively cross-link, radiolabel, and activate the insulin receptor. (1993) (52)
Regulation of IkappaB kinase and NF-kappaB in contracting adult rat skeletal muscle. (2005) (51)
Targeting Inflammation Using Salsalate in Patients With Type 2 Diabetes: Effects on Flow-Mediated Dilation (TINSAL-FMD) (2013) (50)
A Radioimmunoassay for Circulating Human Proinsulin (1985) (50)
Insulin Receptor Activation with Transmembrane Domain Ligands* (2014) (47)
Substitution of the erbB-2 oncoprotein transmembrane domain activates the insulin receptor and modulates the action of insulin and insulin-receptor substrate 1. (1993) (46)
Identification of residues in the beta platelet-derived growth factor receptor that confer specificity for binding to phospholipase C-gamma 1. (1993) (46)
Human insulin B24 (Phe----Ser). Secretion and metabolic clearance of the abnormal insulin in man and in a dog model. (1984) (45)
Effect of Targeting Inflammation With Salsalate: The TINSAL-CVD Randomized Clinical Trial on Progression of Coronary Plaque in Overweight and Obese Patients Using Statins. (2016) (45)
Functional Roles of the Shc Phosphotyrosine Binding and Src Homology 2 Domains in Insulin and Epidermal Growth Factor Signaling* (1996) (43)
NF-κB activation and polyubiquitin conjugation are required for pulmonary inflammation-induced diaphragm atrophy. (2012) (41)
Hepatocyte-specific IKKβ expression aggravates atherosclerosis development in APOE*3-Leiden mice. (2012) (40)
Retinal not systemic oxidative and inflammatory stress correlated with VEGF expression in rodent models of insulin resistance and diabetes. (2012) (40)
Substitution of the insulin receptor transmembrane domain with the c-neu/erbB2 transmembrane domain constitutively activates the insulin receptor kinase in vitro. (1992) (39)
A photoaffinity scan maps regions of the p85 SH2 domain involved in phosphoprotein binding. (1993) (36)
Nonphosphorylatable substrate analogs selectively block autophosphorylation and activation of the insulin receptor, epidermal growth factor receptor, and pp60v-src kinases. (1989) (36)
Paradoxical structure and function in a mutant human insulin associated with diabetes mellitus. (1993) (35)
The phosphopeptide-binding specificity of Src family SH2 domains. (1994) (33)
Expansion and contraction: treating diabetes with bariatric surgery (2009) (31)
JMM – Past and Present (2002) (31)
Solid-phase synthesis of nonhydrolyzable phosphotyrosyl peptide analogues with Nα-Fmoc-(O,O-di-t-butyl)phosphono-p-methylphenylalanine (1991) (31)
Optimizing transmembrane domain helicity accelerates insulin receptor internalization and lateral mobility. (1993) (31)
Cellular effects of phosphotyrosine-binding domain inhibitors on insulin receptor signaling and trafficking (1997) (31)
Insulin differentially regulates protein phosphotyrosine phosphatase activity in rat hepatoma cells. (1992) (31)
Antiinsulin receptor antibodies in an insulin-dependent diabetic may arise as autoantiidiotypes. (1986) (30)
Binding of a High Affinity Phosphotyrosyl Peptide to the Src SH 2 Domain : Crystal Structures of the Complexed and Peptide (2004) (29)
Aspirin reduces hypertriglyceridemia by lowering VLDL-triglyceride production in mice fed a high-fat diet. (2011) (29)
The Impact of Salsalate Treatment on Serum Levels of Advanced Glycation End Products in Type 2 Diabetes (2014) (29)
Shf, a Shb-like Adapter Protein, Is Involved in PDGF-α-Receptor Regulation of Apoptosis (2000) (28)
Role of the Transmembrane Domain and Flanking Amino Acids in Internalization and Down-regulation of the Insulin Receptor * (1995) (28)
Autophosphorylation within insulin receptor beta-subunits can occur as an intramolecular process. (1991) (28)
Banking on ATM as a new target in metabolic syndrome. (2006) (28)
Functional Characterization of Obesity-Associated Variants Involving the α and β Isoforms of Human SH2B1 (2014) (28)
Crystal Structures of Human TBC1D1 and TBC1D4 (AS160) RabGTPase-activating Protein (RabGAP) Domains Reveal Critical Elements for GLUT4 Translocation* (2011) (27)
Multiple Binding Modes between HNF4α and the LXXLL Motifs of PGC-1α Lead to Full Activation* (2009) (26)
Hepatocyte-specific IKK-β activation enhances VLDL-triglyceride production in APOE*3-Leiden mice[S] (2011) (25)
Identification and functional characterization of a novel mutation of hepatocyte nuclear factor-1α gene in a Korean family with MODY3 (2003) (24)
Profilin-1 Haploinsufficiency Protects Against Obesity-Associated Glucose Intolerance and Preserves Adipose Tissue Immune Homeostasis (2013) (24)
Interaction of Shc with Grb2 Regulates the Grb2 Association with mSOS (1995) (23)
Possible v-Crk-induced Transformation through Activation of Src Kinases (*) (1995) (23)
Nonlocal structural perturbations in a mutant human insulin: sequential resonance assignment and 13C-isotope-aided 2D-NMR studies of [PheB24-->Gly]insulin with implications for receptor recognition. (1992) (22)
Cathepsins in Human Obesity: Changes in Energy Balance Predominantly Affect Cathepsin S in Adipose Tissue and in Circulation (2010) (22)
Muscle-Specific Inhibition of the Classical Nuclear Factor-&kgr;B Pathway Is Protective Against Diaphragmatic Weakness in Murine Endotoxemia (2014) (21)
Regulation of Diet-Induced Adipose Tissue and Systemic Inflammation by Salicylates and Pioglitazone (2013) (21)
Evidence for the Presence of Somatostatin 28 in Plasma (1982) (21)
DIABETES MUTATIONS DELINEATE AN ATYPICAL POU DOMAIN IN HNF1A. (2002) (20)
Sustained NFκB inhibition improves insulin sensitivity but is detrimental to muscle health (2017) (20)
Inflammation and obesity: STAMPing out insulin resistance? (2007) (20)
Circulating forms of somatostatinlike immunoreactivity in human plasma. (1986) (20)
Products of Therapeutic Insulins in the Blood of Insulin-dependent (Type I) Diabetic Patients (1985) (19)
Cooperative self-assembly of SH2 domain fragments restores phosphopeptide binding. (1993) (18)
Shf, a Shb-like adapter protein, is involved in PDGF-alpha-receptor regulation of apoptosis. (2000) (15)
Salsalate improves glycaemia in overweight persons with diabetes risk factors of stable statin‐treated cardiovascular disease: A 30‐month randomized placebo‐controlled trial (2017) (15)
Cyclic peptide inhibitors of phosphatidylinositol 3-kinase p85 SH2 domain binding. (1994) (15)
Transmembrane domain inversion blocks ER release and insulin receptor signaling. (1995) (13)
Fat T reg cells : a liaison between the immune and metabolic systems (2011) (13)
X-ray Crystallographic Structure of TIR-Domain from the Human TIR-Domain Containing Adaptor Protein/MyD88 Adaptor-Like Protein (TIRAP/MAL) (2012) (12)
High-performance liquid chromatography (HPLC): A rapid, flexible and sensitive method for separating islet proinsulin and insulin (1986) (11)
An irregularity in the transmembrane domain helix correlates with the rate of insulin receptor internalization. (1994) (11)
Invited comment on W. Ebstein: On the therapy of diabetes mellitus, in particular on the application of sodium salicylate (2002) (10)
Functional characterisation of obesity-associated variants involving the alpha and beta isoforms of human SH 2 B 1 (2014) (10)
Phosphopeptide occupancy and photoaffinity cross-linking of the v-Src SH2 domain attenuates tyrosine kinase activity. (1994) (10)
Sustained NF-κB Activation and Inhibition in β-Cells Have Minimal Effects on Function and Islet Transplant Outcomes (2013) (10)
Norleucine as a replacement for methionine in phosphatase-resistant linear and cyclic peptides which bind to p85 SH2 domains (1994) (8)
Symposium III: Biomarkers of Acute Kidney Injury: Early Diagnosis, Pathogenesis, and Recovery (2007) (8)
NFκB Regulates Muscle Development and Mitochondrial Function. (2018) (8)
TYROSINE PHOSPHATASE SHP-2 (1999) (7)
Effects of the anti-inflammatory drug salsalate on bone turnover in type 2 diabetes mellitus (2015) (6)
Externalized phosphatidylinositides on apoptotic cells are eat-me signals recognized by CD14 (2022) (6)
The carboxy-terminal region of the TBC1D4 (AS160) RabGAP mediates protein homodimerization. (2017) (6)
Response to Comment on Goldfine et al. Targeting Inflammation Using Salsalate in Patients With Type 2 Diabetes: Effects on Flow-Mediated Dilation (TINSAL-FMD). Diabetes Care 2013;36:4132–4139 (2014) (5)
Intermolecular Phosphorylation between Insulin Holoreceptors Does Not Stimulate Substrate Kinase Activity (*) (1995) (4)
Glu-mediated dimerization of the transmembrane region of the oncogenic neu protein (1994) (4)
When a domain is not a domain (2008) (4)
Synthesis and structure-activity studies of SH2 binding peptides containing hydrolytically stable analogs of O -phosphotyrosine (1994) (3)
Structure of the Globular Tail of (2002) (3)
Human GRB-IRβ/GRB10 (1997) (3)
Insulin and Other Antidiabetic Agents (2009) (3)
Genetic variability in insulin action inhibitor Ikkbeta (IKBKB) does not play a major role in the development of type 2 diabetes. (2002) (2)
RabGTPase-activating Protein ( RabGAP ) Domains Reveal Critical Elements for GLUT 4 Translocation * (2011) (2)
COMMENT: Genetic Variability in Insulin Action Inhibitor Ikkβ (IKBKB) Does Not Play a Major Role in the Development of Type 2 Diabetes (2002) (2)
Fat-Specific Expression of Activated IKKβ Causes Insulin Resistance in Mice (2002) (2)
Socs1 Induces Insulin Resistance by Promoting Ubiquitin-Mediated Degradation of IRS1 and IRS2 (2002) (2)
Synthesis and structure activity studies of phosphatase resistant SH2 domain inhibiting peptides: D-amino acid effects (1995) (1)
SYMPOSIUM III (2007) (1)
association of Grb2 with mSOS. Interaction of Shc with Grb2 regulates (2013) (0)
IRS PROTEIN STRUCTURE (2002) (0)
Crystal structure of the PI3-kinase p85 N-terminal SH2 domain in complex with c-Kit phosphotyrosyl peptide (2006) (0)
Crystal structure of the PI3-kinase p85 N-terminal SH2 domain in complex with PDGFR phosphotyrosyl peptide (2006) (0)
HEPATOCYTE NUCLEAR FACTOR 1A BOUND TO DNA : MODY3 GENE PRODUCT (2002) (0)
A photoaffinity scan maps regions of an SH2 domain involved in phosphoprotein interactions (1994) (0)
P408 LIVER-SPECIFIC IKK-β ACTIVATION SEVERELY AGGRAVATES ATHEROSCLEROSIS DEVELOPMENT IN APOE*3-LEIDEN MICE (2010) (0)
TargetingInflammationUsingSalsalatein Patients With Type 2 Diabetes: Effects on Flow-Mediated Dilation (TINSAL-FMD). Diabetes Care 2013;36:4132-4139 (2014) (0)
Abstract: P700 CHRONIC HEPATIC INFLAMMATION SEVERELY AGGRAVATES ATHEROSCLEROSIS DEVELOPMENT (2009) (0)
Hepatocyte-specific inflammation enhances VLDL production in mice (2008) (0)
Use of a Monomeric Insulin Template for Studying Structural Effects of Substitutions within Insulin's Receptor-Binding Surface, (1992) (0)
An Anti-Inflammatory Approach to Treating Diabetes and Atherosclerosis Using Salicylate (2014) (0)
Crystal structure of the PI3-kinase p85 N-terminal SH2 domain (2006) (0)
3 ASPIRIN REDUCES HYPERTRIGLYCERIDEMIA BY LOWERING VLDL-TRIGLYCERIDE PRODUCTION IN MICE FED A HIGH-FAT DIET (2013) (0)
Vascular RAGE transports oxytocin into the brain to elicit its maternal bonding behaviour in mice (2019) (0)
OP031 ROLE OF IGF-I AND TNF-ALPHA/NF-KAPPA B PATHWAY IN THE INDUCTION OF THE TRANSCRIPTIONAL MUSCLE ATROPHY PROGRAM BY ACUTE INFLAMMATION (2012) (0)
Responses of somatostatin components to oral glucose in human plasma. (1983) (0)
Crystal Structure of Human TBC1D1 RabGAP domain (2011) (0)
Determinants of specificity in phosphoprotein/ SH2 domain interactions (1994) (0)
Specific Activation of the Insulin Receptor by the Transmembrane Domain Peptides (2001) (0)
Comparative 2D NMR studies of the Phe B24 → Leu mutant human insulin (1988) (0)
Effects Of Muscle-Specific Inhibition Of The NF-kB Pathway On Diaphragmatic Function In Murine Sepsis (2010) (0)
Physical and Functional Interactions between SH 2 and SH 3 Domains of the Src Family Protein Tyrosine Kinase p 59 fi 5 (0)
Adenovirus-Mediated Expression of Activated IKKβ or Inhibitory IκB Causes Insulin Resistance or Reverses It, Respectively, in Mice (2002) (0)
Blood glucose levels in STZ diabetic male C57BL/6AF1 mice transplanted with 150 fresh islets with administration of salicylate in the water (closed triangles) or regular water (open triangles). (2013) (0)
Bpa-Insulins: Photoactivatable Analogs for Identifying Site-Site Interactions Between Insulin and the Insulin Receptor, (1992) (0)
CRYSTAL STRUCTURE OF THE PH-PTB TARGETING REGION OF IRS-1 (1999) (0)
MATURE HUMAN FRATAXIN (2000) (0)
Crystal structure of HNF4a LBD in complex with the ligand and the coactivator SRC-1 peptide (2004) (0)
Hepatocyte-specific Inflammation Directly Enhances VLDL-triglyceride Production in Mice (2010) (0)
Point-counterpoint: Interleukin-6 does/does not have a beneficial role in insulin sensitivity and glucose homeostasis. (2007) (0)
HNF4a ligand binding domain with bound fatty acid (2003) (0)
Phosphatase-resistant SH2 domain inhibitors (1994) (0)
Structure of Lamin A/C Globular Domain (2002) (0)
NFκB Regulation of Mitochondrial Function in Skeletal and Cardiac Muscle (2018) (0)
insulin sensitivity and glucose homeostasis Interleukin-6 does/does not have a beneficial role in (2007) (0)

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