Stephen F. Lowry

Q: What Schools Are Affiliated With Stephen F. Lowry

Stephen F. Lowry is affiliated with the following schools: University of Amsterdam, University of Florida, Rockefeller University, Cornell University

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Stephen F. Lowry

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Stephen F. Lowry

Biology

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Molecular Biology

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Philosophy
Biology

Stephen F. Lowry's Degrees

PhD Biochemistry University of California, San Francisco
Doctorate Medicine Stanford University

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Stephen F. Lowry's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Shock and tissue injury induced by recombinant human cachectin. (1986) (2564)
Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia (1987) (2498)
Genomic responses in mouse models poorly mimic human inflammatory diseases (2013) (2016)
A network-based analysis of systemic inflammation in humans (2005) (1417)
Treatment of septic shock with the tumor necrosis factor receptor:Fc fusion protein. The Soluble TNF Receptor Sepsis Study Group. (1996) (1069)
A genomic storm in critically injured humans (2011) (949)
Recombinant Human Interleukin 1 Receptor Antagonist in the Treatment of Patients With Sepsis Syndrome: Results From a Randomized, Double-blind, Placebo-Controlled Trial (1994) (889)
Confirmatory interleukin-1 receptor antagonist trial in severe sepsis: a phase III, randomized, double-blind, placebo-controlled, multicenter trial. The Interleukin-1 Receptor Antagonist Sepsis Investigator Group. (1997) (811)
Tumor necrosis factor soluble receptors circulate during experimental and clinical inflammation and can protect against excessive tumor necrosis factor alpha in vitro and in vivo. (1992) (801)
Antibodies to cachectin/tumor necrosis factor reduce interleukin 1 beta and interleukin 6 appearance during lethal bacteremia (1989) (646)
Human toll-like receptor 4 mutations but not CD14 polymorphisms are associated with an increased risk of gram-negative infections. (2002) (598)
Macrophages secrete a novel heparin-binding protein with inflammatory and neutrophil chemokinetic properties (1988) (568)
Cytokine appearance in human endotoxemia and primate bacteremia. (1988) (548)
Epinephrine inhibits tumor necrosis factor-alpha and potentiates interleukin 10 production during human endotoxemia. (1996) (535)
Inflammatory cytokines and cell response in surgery. (2000) (532)
Tumor necrosis factor-a (1991) (499)
Cachectin/tumor necrosis factor induces lethal shock and stress hormone responses in the dog. (1987) (422)
Interleukin-6 gene-deficient mice show impaired defense against pneumococcal pneumonia. (1997) (419)
Acute Inflammatory Response to Endotoxin in Mice and Humans (2005) (394)
The acute splanchnic and peripheral tissue metabolic response to endotoxin in humans. (1990) (361)
IL-8 in septic shock, endotoxemia, and after IL-1 administration. (1991) (311)
Trial of short-course antimicrobial therapy for intraabdominal infection. (2015) (310)
Endogenous IL-10 protects mice from death during septic peritonitis. (1995) (299)
Interleukin-10 impairs host defense in murine pneumococcal pneumonia. (1996) (293)
Glucocorticoid therapy alters hormonal and cytokine responses to endotoxin in man. (1993) (289)
The biologic characteristics of cytokines and their implication in surgical injury. (1990) (256)
Total Parenteral Nutrition and Bowel Rest Modify the Metabolic Response to Endotoxin in Humans (1989) (253)
An overview of mortality risk prediction in sepsis. (1995) (248)
Tumor necrosis factor in sepsis: mediator of multiple organ failure or essential part of host defense? (1995) (245)
Cachectin/tumor necrosis factor‐α alters red blood cell kinetics and induces anemia in vivo (1989) (242)
Application of genome-wide expression analysis to human health and disease. (2005) (240)
Passive immunization against tumor necrosis factor-alpha impairs host defense during pneumococcal pneumonia in mice. (1997) (222)
Anticachectin/tumor necrosis factor‐α antibodies attenuate development of cachexia in tumor models (1989) (220)
Interleukin 1 receptor blockade attenuates the host inflammatory response. (1990) (218)
Tumor necrosis factor in the pathophysiology of infection and sepsis. (1990) (218)
Interleukin-1 receptor antagonist circulates in experimental inflammation and in human disease. (1992) (211)
Cytokine mediators of immunity and inflammation. (1993) (207)
Antiinflammatory cytokine responses during clinical sepsis and experimental endotoxemia: sequential measurements of plasma soluble interleukin (IL)-1 receptor type II, IL-10, and IL-13. (1997) (194)
The mature bone morphogenetic protein-2 is aberrantly expressed in non-small cell lung carcinomas and stimulates tumor growth of A549 cells. (2003) (185)
Effect of a recombinant dimeric tumor necrosis factor receptor on inflammatory responses to intravenous endotoxin in normal humans. (1997) (174)
Cachectin: a hormone that triggers acute shock and chronic cachexia. (1988) (171)
The role of cytokine mediators in septic shock. (1990) (169)
Cachexia and the acute‐phase protein response in inflammation are regulated by interleukin‐6 (1993) (166)
Cachectin/tumor necrosis factor mediates changes of skeletal muscle plasma membrane potential (1986) (164)
Cachetin/TNF-α in Septic Shock and Septic Adult Respiratory Distress Syndrome (1988) (164)
Abnormal liver function during parenteral nutrition: Relation to infusion excess (1979) (162)
CANCER CACHEXIA AND PROTEIN METABOLISM (1984) (162)
Effects of IL-10 on systemic inflammatory responses during sublethal primate endotoxemia. (1997) (161)
Quantitative Proteome Analysis of Human Plasma following in Vivo Lipopolysaccharide Administration Using 16O/18O Labeling and the Accurate Mass and Time Tag Approach*S (2005) (159)
HUMAN ENDOTOXEMIA: A MODEL FOR MECHANISTIC INSIGHT AND THERAPEUTIC TARGETING (2005) (154)
Recombinant human platelet-activating factor acetylhydrolase for treatment of severe sepsis: Results of a phase III, multicenter, randomized, double-blind, placebo-controlled, clinical trial* (2004) (154)
Effects of intravenous IL-8 administration in nonhuman primates. (1992) (141)
APOε4 is associated with enhanced in vivo innate immune responses in human subjects. (2014) (136)
Tumor necrosis factor soluble receptors circulate during experimental and clinical inflammation and can protect against excessive tumor necrosis factor a in vitro and in vivo (135)
Hypercortisolemia increases plasma interleukin-10 concentrations during human endotoxemia--a clinical research center study. (1996) (130)
Peripheral blood leukocyte kinetics following in vivo lipopolysaccharide (LPS) administration to normal human subjects. Influence of elicited hormones and cytokines. (1989) (123)
Interleukin-1 blockade attenuates mediator release and dysregulation of the hemostatic mechanism during human sepsis. (1995) (119)
Comparative proteome analyses of human plasma following in vivo lipopolysaccharide administration using multidimensional separations coupled with tandem mass spectrometry (2005) (114)
Modeling the influence of circadian rhythms on the acute inflammatory response. (2010) (112)
In vivo endotoxin synchronizes and suppresses clock gene expression in human peripheral blood leukocytes* (2010) (111)
Persistently elevated soluble tumor necrosis factor receptor and interleukin-1 receptor antagonist levels in critically ill patients. (1994) (105)
Benefit/risk profile of drotrecogin alfa (activated) in surgical patients with severe sepsis. (2004) (103)
Increased neutrophil mobilization and decreased chemotaxis during cortisol and epinephrine infusions. (1991) (103)
Isolated aneurysms of the iliac artery. (1978) (102)
Biologic Control of Injury and Inflammation: Much More than Too Little or Too Late (1996) (99)
Efficacy and safety of LY315920Na/S-5920, a selective inhibitor of 14-kDa group IIA secretory phospholipase A2, in patients with suspected sepsis and organ failure (2003) (99)
Roles of SIRT1 in the Acute and Restorative Phases following Induction of Inflammation* (2010) (97)
Catecholamines increase monocyte TNF receptors and inhibit TNF through β2-adrenoreceptor activation. (1997) (94)
Harry M. Vars award. Glutamine or fiber supplementation of a defined formula diet: impact on bacterial translocation, tissue composition, and response to endotoxin. (1990) (93)
Epinephrine inhibits endotoxin-induced IL-1β production: roles of tumor necrosis factor-α and IL-10. (1997) (93)
Interleukin-1 alpha and tumor necrosis factor alpha cause placental injury in the rat. (1989) (93)
One hundred and fourteen fistulas of the gastrointestinal tract treated with total parenteral nutrition. (1986) (92)
The route of feeding influences injury responses. (1990) (91)
Postoperative Sepsis in the United States (2010) (91)
Elevation of IL-18 in Human Sepsis (2000) (90)
Changes in endotoxin-induced cytokine production by whole blood after in vivo exposure of normal humans to endotoxin. (1996) (88)
Infectious complications after elective vascular surgical procedures. (2010) (87)
Essential fatty acid deficiency in total parenteral nutrition: time course of development and suggestions for therapy. (1978) (85)
Effects of Drotrecogin Alfa (Activated) in Human Endotoxemia (2004) (85)
Agent-Based Modeling of Endotoxin-Induced Acute Inflammatory Response in Human Blood Leukocytes (2010) (83)
Lipopolysaccharide-induced interleukin 8 production by human whole blood is enhanced by epinephrine and inhibited by hydrocortisone (1997) (83)
Recombinant human growth hormone enhances the metabolic efficacy of parenteral nutrition: a double-blind, randomized controlled study. (1992) (82)
Modeling endotoxin-induced systemic inflammation using an indirect response approach. (2009) (82)
Recombinant platelet-activating factor acetylhydrolase to prevent acute respiratory distress syndrome and mortality in severe sepsis: Phase IIb, multicenter, randomized, placebo-controlled, clinical trial. (2003) (81)
Interleukin-1 receptor blockade does not affect endotoxin-induced changes in plasma thyroid hormone and thyrotropin concentrations in man. (1995) (80)
Bacterial overgrowth and intestinal atrophy in the etiology of gut barrier failure in the rat. (1991) (79)
Modulation of the Lipopolysaccharide Receptor Complex (CD14, TLR4, MD-2) and Toll-Like Receptor 2 in Systemic Inflammatory Response Syndrome-Positive Patients With and Without Infection: Relationship to Tolerance (2003) (78)
Endotoxin induces downregulation of tumor necrosis factor receptors on circulating monocytes and granulocytes in humans. (1995) (77)
Integrins are required for the differentiation of visceral endoderm (2009) (76)
In vivo effects of the antiglucocorticoid RU 486 on glucocorticoid and cytokine responses to Escherichia coli endotoxin (1992) (75)
Changes in polymorphonuclear leukocyte surface and plasma bactericidal/permeability-increasing protein and plasma lipopolysaccharide binding protein during endotoxemia or sepsis. (1994) (75)
Influence of IL-1 receptor blockade on the human response to endotoxemia. (1995) (74)
Identification of a novel tumor necrosis factor alpha/cachectin from the livers of burned and infected rats. (1990) (74)
A prospective, randomized study of adjuvant parenteral nutrition in the treatment of sarcomas: results of metabolic and survival studies. (1984) (73)
Cachectin/TNF production in experimental burns and Pseudomonas infection. (1988) (73)
Contribution of interleukin-1 to activation of coagulation and fibrinolysis, neutrophil degranulation, and the release of secretory-type phospholipase A2 in sepsis: studies in nonhuman primates after interleukin-1 alpha administration and during lethal bacteremia (1995) (73)
In-hospital delay of elective surgery for high volume procedures: the impact on infectious complications. (2010) (72)
Secretory leukocyte protease inhibitor, an inhibitor of neutrophil activation, is elevated in serum in human sepsis and experimental endotoxemia (2000) (69)
Epinephrine inhibits endotoxin-induced IL-1 beta production: roles of tumor necrosis factor-alpha and IL-10. (1997) (69)
The role of cytokines in cancer cachexia. (1992) (68)
Voluntarily Produced Increases in Heart Rate Variability Modulate Autonomic Effects of Endotoxin Induced Systemic Inflammation: An Exploratory Study (2010) (67)
Recombinant growth hormone enhances muscle myosin heavy-chain mRNA accumulation and amino acid accrual in humans. (1989) (67)
Lipopolysaccharide and sepsis-associated myocardial dysfunction (2011) (65)
Insulin-like growth factor-1 activity is inhibited by interleukin-1 alpha, tumor necrosis factor-alpha, and interleukin-6. (1993) (64)
Cachectin: its impact on metabolism and nutritional status. (1988) (63)
In Silico Simulation of Corticosteroids Effect on an NFkB- Dependent Physicochemical Model of Systemic Inflammation (2009) (62)
Tolerance to endotoxin prevents mortality in infected thermal injury: association with attenuated cytokine responses. (1992) (61)
Protection against lethal Escherichia coli bacteremia in baboons (Papio anubis) by pretreatment with a 55-kDa TNF receptor (CD120a)-Ig fusion protein, Ro 45-2081. (1996) (61)
Influence of hypercortisolemia on soluble tumor necrosis factor receptor II and interleukin-1 receptor antagonist responses to endotoxin in human beings. (1995) (60)
Epinephrine Exerts Anticoagulant Effects during Human Endotoxemia (1997) (60)
Inflammation and the Host Response to Injury, a large-scale collaborative project: Patient-Oriented Research Core--standard operating procedures for clinical care. I. Guidelines for mechanical ventilation of the trauma patient. (2005) (60)
A human tumor necrosis factor p75 receptor agonist stimulates in vitro T cell proliferation but does not produce inflammation or shock in the baboon (1996) (60)
Tumor necrosis factor-alpha induces activation of coagulation and fibrinolysis in baboons through an exclusive effect on the p55 receptor. (1996) (57)
The effect of total parenteral nutrition on chemotherapy-induced myelosuppression. A randomized study. (1983) (57)
Influence of hypercortisolemia on the acute-phase protein response to endotoxin in humans. (1992) (57)
Trends in postoperative sepsis: are we improving outcomes? (2009) (57)
Effect of hypertriglyceridemia on endotoxin responsiveness in humans (1995) (56)
Entrainment of peripheral clock genes by cortisol. (2012) (55)
Metabolic alterations in a noncachectic animal tumor system (1981) (55)
Monocyte tumor necrosis factor receptor levels as a predictor of risk in human sepsis. (1996) (52)
RELATIONSHIP OF BASAL HEART RATE VARIABILITY TO IN VIVO CYTOKINE RESPONSES after endotoxin exposure (2010) (51)
GENDER INFLUENCES IN VIVO HUMAN RESPONSES TO ENDOTOXIN (2006) (51)
Modeling autonomic regulation of cardiac function and heart rate variability in human endotoxemia. (2011) (51)
Significant reduction in incidence of wound contamination by skin flora through use of microbial sealant. (2008) (50)
Insulin-like growth factor I preserves host lean tissue mass in cancer cachexia. (1992) (47)
Contribution of interleukin-1 to activation of coagulation and fibrinolysis, neutrophil degranulation, and the release of secretory-type phospholipase A2 in sepsis: studies in nonhuman primates after interleukin-1 alpha administration and during lethal bacteremia. (1995) (47)
Low-dose steroid alters in vivo endotoxin-induced systemic inflammation but does not influence autonomic dysfunction (2007) (47)
Cancer cachexia and the rate of whole body lipolysis in man. (1986) (47)
Appearance of hybridoma growth factor/interleukin-6 in the serum of mice bearing a methylcholanthrene-induced sarcoma. (1988) (46)
Influence of Acute Epinephrine Infusion on Endotoxin-Induced Parameters of Heart Rate Variability: A Randomized Controlled Trial (2009) (46)
Tumor necrosis factor-enhanced leukotriene B4 generation and chemotaxis in human neutrophils. (1988) (45)
The Human Response to Endotoxin (1998) (45)
Catecholamines increase monocyte TNF receptors and inhibit TNF through beta 2-adrenoreceptor activation. (1997) (45)
Interleukin-1α (IL-1α) and Tumor Necrosis Factor α (TNFα) Regulate Insulin-Like Growth Factor Binding Protein-1 (IGFBP-1) Levels and mRNA Abundance In Vivo and In Vitro* (1999) (44)
Multiscale model for the assessment of autonomic dysfunction in human endotoxemia. (2010) (44)
PEG-BP-30 monotherapy attenuates the cytokine-mediated inflammatory cascade in baboon Escherichia coli septic shock. (1995) (43)
Whole body and splanchnic leucine, phenylalanine, and glucose kinetics during endotoxemia in humans. (1994) (42)
A Physiological Model for Autonomic Heart Rate Regulation in Human Endotoxemia (2011) (42)
Down-regulation of surface receptors for TNF and IL-1 on circulating monocytes and granulocytes during human endotoxemia: effect of neutralization of endotoxin-induced TNF activity by infusion of a recombinant dimeric TNF receptor. (1997) (42)
Protein and substrate metabolism during starvation and parenteral refeeding. (1988) (39)
Response to systemic endotoxemia among humans bearing polymorphisms of the Toll-like receptor 4 (hTLR4). (2006) (39)
Nutritional manipulations and tumor growth. II. The effects of intravenous feeding. (1979) (39)
Talin1 Regulates Integrin Turnover To Promote Embryonic Epithelial Morphogenesis (2011) (39)
Nutritional support and cancer cachexia. Evolving concepts of mechanisms and adjunctive therapies. (1991) (38)
Transcriptional implications of ultradian glucocorticoid secretion in homeostasis and in the acute stress response. (2012) (38)
The metabolic effects of platelet-activating factor antagonism in endotoxemic man. (1994) (38)
Impact of infectious complications after elective surgery on hospital readmission and late deaths in the U.S. Medicare population. (2012) (38)
Effect of total parenteral nutrition on whole body protein kinetics in cachectic patients with benign or malignant disease. (1988) (38)
Cachectin/TNF mediates the pathophysiological effects of bacterial endotoxin/lipopolysaccharide (LPS). (1988) (37)
Inflammatory cytokines in major surgery: a functional perspective (1999) (37)
Anti‐Endotoxin Therapy in Primate Bacteremia with HA‐1A and BPI (1994) (37)
Parenteral vitamin requirements during intravenous feeding. (1978) (37)
Nutritional modulation of immunity and the inflammatory response. (1998) (37)
Translational Potential of Systems‐Based Models of Inflammation (2009) (37)
Cachetin/TNF-alpha in septic shock and septic adult respiratory distress syndrome. (1988) (36)
Role of interleukin-1 and the therapeutic potential of interleukin-1 receptor antagonist in sepsis. (1994) (36)
Interleukin 1 binding to its type I, but not type II receptor, modulates the in vivo acute phase response. (1995) (36)
Tracer priming in human protein turnover studies with [15N]glycine. (1985) (34)
Inflammation and the host response to injury, a large-scale collaborative project: patient-oriented research core--standard operating procedures for clinical care VIII--Nutritional support of the trauma patient. (2008) (34)
Whole-body protein breakdown and 3-methylhistidine excretion during brief fasting, starvation, and intravenous repletion in man. (1985) (34)
The stressed host response to infection: the disruptive signals and rhythms of systemic inflammation. (2009) (33)
Body weight change and nutritional adequacy in the parenterally alimented rat. (1978) (33)
Abnormalities of zinc and copper during total parenteral nutrition. (1979) (33)
Challenges for modeling and interpreting the complex biology of severe injury and inflammation (2008) (32)
Rac1 Is Essential for Basement Membrane-Dependent Epiblast Survival (2010) (31)
Physiological responses to cachectin. (1987) (31)
Fat Emulsion Infusion Potentiates Coagulation Activation during Human Endotoxemia (1996) (31)
Total parenteral nutrition in patients with insulin-requiring diabetes mellitus. (1986) (31)
Nutritional manipulations and tumor growth. I. The effects of starvation. (1979) (31)
Comparison of Peripheral Blood Leukocyte Kinetics After Live Escherichia coli, Endotoxin, or Interleukin‐1 α Administration Studies Using a Novel Interleukin‐1 Receptor Antagonist (1993) (30)
Effect of chronic protein malnutrition on host-tumor composition and growth. (1979) (29)
Microfluidic leukocyte isolation for gene expression analysis in critically ill hospitalized patients. (2008) (29)
Sepsis and its complications: clinical definitions and therapeutic prospects. (1994) (28)
A dual negative regulation model of Toll-like receptor 4 signaling for endotoxin preconditioning in human endotoxemia. (2011) (28)
The effects of glucocorticoid therapy on inflammatory responses to coronary artery bypass graft surgery. (2001) (28)
International integrated database for the evaluation of severe sepsis and drotrecogin alfa (activated) therapy: analysis of efficacy and safety data in a large surgical cohort. (2006) (28)
Selective Activation of Peripheral Blood T Cell Subsets by Endotoxin Infusion in Healthy Human Subjects Corresponds to Differential Chemokine Activation1 (2005) (28)
Interleukin-1 alpha (IL-1 alpha) and tumor necrosis factor alpha (TNF alpha) regulate insulin-like growth factor binding protein-1 (IGFBP-1) levels and mRNA abundance in vivo and in vitro. (1999) (27)
Modulating the metabolic response to injury and infection (1992) (27)
Efficacy of nutritional pharmacology in surgical patients. (1998) (26)
A novel model of common Toll-like receptor 4- and injury-induced transcriptional themes in human leukocytes (2010) (26)
Cdc42 Controls Vascular Network Assembly Through Protein Kinase C&igr; During Embryonic Vasculogenesis (2011) (25)
Influence of the TNF-α and TNF-β polymorphisms upon infectious risk and outcome in surgical intensive care patients (2003) (25)
Effect of the route of nutrient administration on whole-body protein kinetics in man. (1987) (24)
Deep Venous Thromboembolism in Patients Undergoing Inguinal Lymph Node Dissection for Melanoma (1981) (23)
International integrated database for the evaluation of severe sepsis and drotrecogin alfa (activated) therapy: analysis of efficacy and safety data in a large surgical cohort. (2007) (23)
Parenteral nutrition and liver dysfunction--new insight? (1995) (23)
Comparison of numerical and phenotypic leukocyte changes during constant hydrocortisone infusion in normal humans with those in thermally injured patients. (1987) (23)
The lack of an effect by insulin or insulin-like growth factor-1 in attenuating colon-2-mediated cancer cachexia. (1996) (23)
Epinephrine attenuates down‐regulation of monocyte tumor necrosis factor receptors during human endotoxemia (1997) (22)
Computational Identification of Transcriptional Regulators in Human Endotoxemia (2011) (22)
Cachectin: a pluripotent hormone released during the host response to invasion. (1987) (22)
Effect of work-induced hypertrophy on skeletal muscle of tumor- and nontumor-bearing rats. (1979) (22)
Starvation leads to decreased levels of mRNA for myofibrillar proteins. (1989) (22)
Zinc and copper replacement during total parenteral nutrition. (1981) (22)
Effect of prostaglandin E in multiple experimental models. IV. Effect on resistance to endotoxin and tumor necrosis factor shock. (1990) (22)
Neutralization of TNF does not influence endotoxininduced changes in thyroid hormone metabolism in humans. (1999) (21)
Influence of increasing dietary intake on whole body protein kinetics in normal man. (1986) (20)
Impact of exogenous growth hormone on host preservation and tumor cell-cycle distribution in a rat sarcoma model. (1991) (20)
The Impact of Hospital Volume on the Development of Infectious Complications After Elective Abdominal Aortic Surgery in the Medicare Population (2011) (20)
Parenteral nutrition facilitates activation of coagulation but not of fibrinolysis during human endotoxemia. (1998) (20)
The pathophysiologic role of cachectin/TNF in septic shock and cachexia. (1988) (19)
Extremity amino acid metabolism during starvation and intravenous refeeding in humans. (1986) (19)
Measurement of Inflammatory Mediators in Clinical Sepsis (1995) (19)
Orotic acid excretion during starvation and refeeding in normal men. (1985) (19)
Physiologic Variability at the Verge of Systemic Inflammation: Multiscale Entropy of Heart Rate Variability Is Affected by Very Low Doses of Endotoxin (2015) (19)
Multivariate analysis of 9 disease-associated variables for outcome prediction in patients with sepsis. (1998) (19)
Effect of Combined Cortisol-Endotoxin Administration on Peripheral Blood Leukocyte Counts and Phenotype in Cortisol-Endotoxin (1992) (18)
The influence of human endotoxemia on CD95-induced apoptosis. (1998) (17)
Low plasma carnitine in patients on prolonged total parenteral nutrition: association with low plasma lysine. (1990) (17)
Cachetin/TNF: a macrophage protein that induces cachexia and shock. (1988) (17)
Hormonal regulation of protein metabolism. (1990) (16)
A multiscale modeling approach to inflammation: A case study in human endotoxemia (2013) (16)
Metabolic alterations in a noncachectic animal tumor system. (1981) (16)
An Agent-Based Model of Cellular Dynamics and Circadian Variability in Human Endotoxemia (2013) (15)
Influence of enterectomy on peripheral tissue glutamine efflux in critically ill patients. (1990) (15)
Safety of drotrecogin alfa (activated) in surgical patients with severe sepsis. (2004) (15)
Influence of substrate background on peripheral tissue responses to growth hormone. (1988) (15)
Appendicitis and appendiceal abscess (2012) (15)
Surgery: Basic science and clinical evidence: Second edition (2008) (15)
Glucose Disposal and Gluconeogenesis From Alanine in Tumor-Bearing Fischer Gluconeogenesis 344 Rats (1981) (15)
Glucose turnover and gluconeogenesis in a patient with somatostatinoma. (1981) (15)
Skeletal muscle amino acid and myofibrillar protein mRNA response to thermal injury and infection. (1991) (14)
Biological Responses to Endotoxin in Humans1 (1995) (14)
Exercise-mediated peripheral tissue and whole-body amino acid metabolism during intravenous feeding in normal man. (1989) (14)
Pretreatment with a 55-kDa tumor necrosis factor receptor-immunoglobulin fusion protein attenuates activation of coagulation, but not of fibrinolysis, during lethal bacteremia in baboons. (1997) (14)
Cachectin/tumor necrosis factor production by fetal and newborn rat hepatic macrophages. (1989) (14)
Corrigendum: A network-based analysis of systemic inflammation in humans (2005) (14)
The evolution of an inflammatory response. (2009) (14)
The influence of substrate background on the acute metabolic response to epinephrine and cortisol. (1991) (13)
The effect of interleukin-1α and tumor necrosis factor α on the secretion of human chorionic gonadotropin by JAR human choriocarcinoma cells (1989) (13)
Influence of the TNF-alpha and TNF-beta polymorphisms upon infectious risk and outcome in surgical intensive care patients. (2003) (13)
Fas-Mediated Neutrophil Apoptosis and Associated A1 Protein Expression During Systemic Inflammation Are Regulated Independently of Both Tumor Necrosis Factor Receptors (2003) (13)
Elemental diet promotes spontaneous bacterial translocation and alters mortality after endotoxin challenge (1989) (13)
Parenteral nutrition alters monocyte TNF receptor activity. (1995) (13)
Interleukin-1 contributes to increased concentrations of soluble tumor necrosis factor receptor type I in sepsis. (1995) (13)
Endogenous Mechanisms Regulating TNF and IL-1 during Sepsis (1995) (12)
ACTIVATED PROTEIN C SUPPRESSES ADRENOMEDULLIN AND AMELIORATES LIPOPOLYSACCHARIDE-INDUCED HYPOTENSION (2007) (12)
The effect of starvation and total parenteral nutrition on skeletal muscle amino acid content and membrane potential difference in normal man. (1988) (12)
Effect of combined cortisol-endotoxin administration on peripheral blood leukocyte counts and phenotype in normal humans. (1992) (12)
Peripheral tissue metabolism in man with varied disease states and similar weight loss. (1986) (12)
Neutralization of TNF does not influence endotoxininduced changes in thyroid hormone metabolism in humans. (1999) (11)
Predictors of educational outcome: factors impacting performance on a standardized clinical evaluation. (2002) (11)
Selectin neutralization: does it make biological sense? (1999) (11)
Tumour location influences local cytokine production and host metabolism. (1992) (11)
Static and dynamic assessment of biomarkers in surgical patients with severe sepsis. (2004) (10)
Anticytokine therapies in sepsis. (1993) (10)
Cellular Metabolic Regulators: Novel Indicators of Low-Grade Inflammation in Humans (2014) (10)
Effect of protein malnutrition on host-tumor composition and growth. (1977) (10)
Pulsatile Glucocorticoid Secretion: Origins and Downstream Effects (2011) (10)
Hormone and Cytokine Regulation of Injury Metabolism (1993) (10)
The role of house staff in undergraduate surgical education. (1976) (9)
The response of fibronectin to differing parenteral caloric sources in normal man. (1985) (9)
POLYMORPHISMS OF HEAT SHOCK PROTEIN-70 (HSPA1B AND HSPA1L LOCI) DO NOT INFLUENCE INFECTION OR OUTCOME RISK IN CRITICALLY ILL SURGICAL PATIENTS (2006) (9)
Alterations in Immunocyte Tumor Necrosis Factor Receptor and Apoptosis in Patients With Congestive Heart Failure (2002) (9)
Insulin-like growth factor binding protein-3 is upregulated in LPS-treated THP-1 cells. (2002) (9)
Protein Synthesis Efficiency and the Route of Nutrient Administration in Man (1987) (8)
Cytokine Markers of the Human Response to Sepsis (1994) (8)
Endogenous cachectin/tumour necrosis factor-alpha production contributes to experimental cancer-associated cachexia. (1989) (8)
The role of bactericidal/permeability-increasing protein in the treatment of primate bacteremia and septic shock (1994) (8)
The biologic control of systemic inflammatory response (1997) (8)
Host metabolic response to injury (1986) (8)
Modeling the human injury response (2010) (8)
Glucose turnover and gluconeogenesis during hypocaloric glucose infusion in tumor-bearing F344 male rats. (1980) (8)
A single nucleotide polymorphism in the Mdm2 promoter and risk of sepsis. (2009) (8)
Hepatocellular membrane function during chronic burn injury. (1989) (8)
Body protein kinetics during perioperative intravenous nutritional support. (1986) (8)
Interleukin‐1 and Interleukin‐6 Synergize to Increase Plasma Amyloid P and C3 Concentrations in the Mouse a (1989) (8)
TUMOR NECROSIS FACTOR RECEPTOR REGULATION OF BONE MARROW CELL APOPTOSIS DURING ENDOTOXIN-INDUCED SYSTEMIC INFLAMMATION (2006) (8)
An indirect response model of endotoxin-induced systemic inflammation (2007) (8)
Submaximal Exercise During Intravenous Hyperalimentation of Depleted Subjects (1988) (7)
Glucose disposal and gluconeogenesis from alanine in tumor-bearing Fischer 344 rats. (1981) (7)
LPS-induced decrease of neutrophil apoptosis is regulated through TLR2, not through TLR4 (2004) (7)
Intravenous refeeding blocks growth hormone (GH)-provoked rises in serum free fatty acids and blunting of somatotroph response to GH-releasing hormone in normal men. (1989) (7)
Protean Manifestations of Neonatal Hyperinsulinism (1981) (7)
RELATIONSHIP OFBASAL HEART RATE VARIABILITY TO IN VIVO CYTOKINE RESPONSES FOLLOWING ENDOTOXIN (2009) (6)
Correlation between Acute Physiology and Chronic Health Evaluation (APACHE) III score and immunological parameters in critically ill patients with sepsis (1996) (6)
Effect of starvation and total parenteral nutrition on electrolyte homeostasis in normal man. (1988) (6)
Continuous Enteral and Parenteral Feeding Each Reduces Heart Rate Variability But Differentially Influences Monocyte Gene Expression in Humans (2012) (6)
Effects of anti-interleukin 6 on inflammatory responses during murine septic peritonitis (1996) (5)
DROTRECOGIN ALFA (ACTIVATED) IN A HUMAN ENDOTOXIN MODEL: 440 (2002) (5)
Endogenous interleukin-10 protects against death in septic peritonitis in mice (1994) (5)
Effect of hormonal and substrate backgrounds on cell membrane function in normal males. (1987) (5)
Cachectin/tumor necrosis factor participates in reduction of skeletal muscle membrane potential: Evidence for bioactivity in plasma during critical illness (1986) (5)
A new model of nutrition influenced inflammatory risk. (2007) (5)
Composition and functional consequences of fiber and glutamine supplementation of enteral diets (1989) (5)
Determine whether 1 week of total parenteral nutrition (TPN) in healthy subjects alters systemic responses to a subsequent dose of endotoxin. (1996) (5)
Strategies for Modulation of Systemic and Tissue Cytokine Responses to Sepsis (1992) (4)
Circulating cytokine antagonists in endotoxemia and sepsis (1993) (4)
Modulation of Cytokine Responses in Sepsis a (1993) (4)
Cytokines and Cytokine Antagonists in Sepsis and Critical Illness (1992) (4)
Tumor Necrosis Factor and Other Cytokines as Mediators of Clinical Sepsis (1993) (4)
Mediators of Inflammation and Injury (2008) (3)
A multiscale model for the assessment of autonomic dysfunction in human endotoxemia (2009) (3)
Nutrient modification of inflammatory mediator production. (1994) (3)
Effect of indomethacin on resistance to endotoxin shock (1990) (3)
Experimental and clinical applications of molecular cell biology in nutrition and metabolism. (1992) (3)
Modulation of the Cytokine Response in Sepsis (1991) (3)
Metabolic Responses to Anti-Cytokine Therapies (1993) (3)
Brain Disorders in Critical Illness: Autonomic dysfunction in SIRS and sepsis (2013) (3)
The need for flexibility in the operative management of type III paraesophageal hernias. (2006) (3)
Review: Experimental and Clinical Applications of Molecular Cell Biology in Nutrition and Metabolism (1992) (3)
2008 Surgical Infection Society Presidential Address The Value of Connections (2009) (3)
Essential Practice of Surgery (2003) (3)
Tumor Necrosis Factor-cw Induces Activation of Coagulation and Fibrinolysis in Baboons Through an Exclusive Effect on the p 55 Receptor (2002) (3)
A Role for Interleukin-1 in Septic Shock (1993) (3)
Substrate Metabolism in Surgery (2001) (2)
Towards in silico models of decomplexification in human endotoxemia (2011) (2)
Tumor Necrosis Factor as a Mediator of Sepsis (1993) (2)
Comprar Surgery · Basic Science and Clinical Evidence | Norton, Jeffrey A. | 9780387308005 | Springer (2008) (2)
Infected burn injury alters hepatic monokine and albumin mRNA contents (1988) (2)
endotoxin infusion in human volunteers: Assessment of the early cellular membrane response (1987) (2)
Influence of nutritional status on exertion-induced forearm amino acid metabolism in normal man. (1984) (2)
THE SAFETY OF DROTRECOGIN ALFA (ACTIVATED): INDEPTH DATA ANALYSIS SUGGESTS SURVIVAL BENEFIT INDEPENDENT OF SERIOUS ADVERSE EVENT OCCURRENCES (2005) (2)
University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School. (2010) (2)
Thermogenic and nitrogen response to submaximal exercise in parenterally repleted normal man. (1987) (2)
TNF Receptor (TNFR) regulation of Fas-mediated polymorphonuclear cell (PMN) apoptosis during systemic inflammation (2000) (1)
Tumor necrosis factor-alpha. (1991) (1)
LPS modulates monocyte cell surface and genomic expression of scavenger receptors (2007) (1)
DIFFERENTIAL CELL DEATH GENE EXPRESSION IN MONOCYTES FROM LPS-CHALLENGED HEALTHY HUMAN VOLUNTEERS PRE-TREATED WITH CORTISOL (2006) (1)
Influence of gender on endotoxin-induced parameters of heart rate variability and innate immune response (2008) (1)
Modeling Circadian Rhythms in Inflammation (2010) (1)
Nutrition in burn patients. (1993) (1)
Influence of tumor location on cytokine production and host metabolism (1990) (1)
Glucose turnover and gluconeogenesis from alanine in tumor-bearing animals. (1978) (1)
Colon and Rectum (2005) (1)
Instantaneous frequency analysis shows greater sensitivity to parasympathetic components of heart rate than spectral analysis (2013) (1)
Cytokines and Their Soluble Antagonists in Sepsis and Critical Illness1 (1995) (1)
Fluid, Electrolyte, and Acid-Base Disorders in the Surgery Patient (2005) (1)
Disordered Apoptosis as a Mechanism for Adverse Outcome (1997) (1)
RNA Silencing in Surgical Disease—Invited Critique (2003) (0)
Agent based of human endotoxemia accounting for circadian variability (2011) (0)
, in Mice and Humans Acute Inflammatory Response to Endotoxin (2004) (0)
Cachectin/TNF: A Mediator of Lethal Endotoxemia (1987) (0)
Integrin-mediated upregulation of cyclooxygenase-2 in monocytes is dependent on extracellular signal-related kinase (ERK) phosphorylation (2000) (0)
Interleukin-1 causes a decrease in plasma IGF-1 concentrations in baboons (1990) (0)
WHAT'S NEW IN SHOCK, AUGUST 2007? (2007) (0)
Understanding homeostatic dynamics of the HPA axis using a glucocorticoid pulsatile model (2011) (0)
Dynamic Complexity of the Temporal Transcriptional Regulation Program in Human Endotoxemia (2010) (0)
Thanks for the memories... (2010) (0)
Insulin or insulin-like growth factor-1 do not attenuate the cachexia in colon-26 cancer (1995) (0)
Inflammation: How Much Is Too Much and Can It Be Controlled? (1999) (0)
Learning Surgery: The Surgery Clerkship Manual (2006) (0)
Influences on insulin-like growth factor-1 in burned infected rats (1993) (0)
T Cell Subpopulations Following Thermal Injury Effect of the Acute Stress Response (1987) (0)
Secretory Leukocyte Protease Inhibitor, an Inhibitor of Neutrophil Activation, Is Elevated in Serum in Human Sepsis and Correlates With Severity of Organ Dysfunction: (1999) (0)
Back to the future: is lipid A an appropriate target for the therapy of sepsis? (2000) (0)
CHAPTER 32: MALNUTRITION (2001) (0)
The heart rate variability and entropy gaps of serious injury (2010) (0)
Preservation of functional aerobic capacity with daily submaximal exercise during intravenous feeding in hospitalized normal man (1988) (0)
RR23. Infectious Complications after Elective Open AAA Repair: Impact of Leapfrog Volume Criteria, Hospital Characteristics, and Patient Demographics (2009) (0)
534b) Peripheral clock gene entrainment by cortisol (2011) (0)
INCREASED NEUTROPHIL (PMN) MOBILIZATION AND DECREASED CHEMOTAXIS (CTX) DURING CORTISOL (CORT) AND EPINEPHRINE (EPI) INFUSIONS (1990) (0)
A Human Tumor Necrosis Factor (TNF) c~ Mutant That Binds Exclusively to the p55 TNF Receptor Produces Toxicity in the Baboon By Kimberly (2003) (0)
List of Contributors and Discussants (1981) (0)
Counterregulation of Severe Inflammation: When More is Too Much and Less is Inadequate (2000) (0)
UvA-DARE (Digital Academic Repository) Epinephrine exerts anticoagulant effects during human endotoxemia (1997) (0)
Implications of ultradian rhythms in glucocorticoid secret (2011) (0)
In silico simulation of corticosteroids effect on a nuclear factor - Kb dependent indirect response model of systemic inflammation in peripheral human blood leukocytes (2008) (0)
The Metabolic Impact of Gluconeogenic Blockade in Tumor‐Bearing Man (1984) (0)
Differential metabolic response of myocardial versus skeletal muscle during catabolic postburn infection (1989) (0)
MORTALITY RISK PREDICTION IN SEPSIS. AUTHORS' REPLY (1995) (0)
INDEPTH DATABASE OF SEVERE SEPSIS PATIENTS SHOWS FEWER CARDIAC EVENTS IN DROTRECOGIN ALFA (ACTIVATED) PATIENTS VS PLACEBO PATIENTS (2005) (0)
Vitamin requirements of intravenously fed man. (1985) (0)
RU 486on Glucocorticoid andCytokine Responses to Escherichia coli Endotoxin (1992) (0)
Cortisol alters tnf-receptor associated factor expression in vivo before and after IPS exposure (2006) (0)
Rapid Communication lnterleukin-1 a and Tumor Necrosis Factor a Cause Placental Injury in the Rat (2007) (0)
Whole‐body Protein Breakdown and 3‐Methylhistidine Excretion During Brief Fasting, Starvation, and Intravenous Repletion in Man (1985) (0)
Impact of a teaching OSCE on RIME skills (2003) (0)
Hormone-cytokine responses to total parenteral nutrition in humans (1990) (0)
What's new in Shock, August 2008? (2008) (0)
Differential Chemokine Activation Healthy Human Subjects Corresponds to Cell Subsets by Endotoxin Infusion in Selective Activation of Peripheral Blood T (2005) (0)
Variation of endogenous endotoxin immunity between UK and US surgical patients (1999) (0)
Perspectives on healthcare from the 2011 Edward J. Ill Excellence in Medicine honorees. (2011) (0)
What's new in Shock, February 2008? (2008) (0)
SS23. The Incidence of Infectious Complications After Elective Vascular Surgery in the United States (2009) (0)
Interactions Between Cytokine Production and Inflammation to Infection (2020) (0)
8: Relationship between endotoxin antibodies and the pro-inflammatory response to endotoxin challenge in healthy subjects (1998) (0)
Clinical administration of LPS endotoxin show changes in heart rate variability are detected prior to changes in temperature (2014) (0)
WHAT'S NEW IN SHOCK, MARCH 2009? (2009) (0)
A physiologic model for autonomic heart rate regulation in human endotoxemia (2011) (0)
The effect of interleukin-1 alpha and tumor necrosis factor alpha on the secretion of human chorionic gonadotropin by JAR human choriocarcinoma cells. (1989) (0)
Recruiting students into surgery (2003) (0)
Multiscale rhythmic influences on heart rate variability in human endotoxemia (2012) (0)
WHAT'S NEW IN SHOCK, MARCH 2007? (2007) (0)
Monocyte gene expression is effected by route of feeding in healthy human volunteers (2005) (0)
WHAT'S NEW IN SHOCK, NOVEMBER 2007? (2007) (0)
Mortality Risk Prediction in Sepsis (1995) (0)
Preservation of functional aerobic capacity with daily submaximal exercise during intravenous feeding in hospitalized normal man. (1988) (0)
(243b) Multiscale variability in human endotoxemia: Circadian, ultradian, and higher frequency rhythms in heart rate variability (2011) (0)
What's New in SHOCK, April 2011? (2011) (0)
What's new in Shock, November 2008? (2008) (0)
Decreased communication leads to diminished physiologic variability in a multiscale model of inflammation (2011) (0)
Autonomic dysregulation precedes evidence of systemic inflammation in endotoxinemia (2009) (0)
LPS INFUSION IN HUMAN VOLUNTEERS IMPAIRS MONOCYTE LPS‐STIMULATED MITOGEN ACTIVATED PROTEIN KINASE (MAPK): 244 (2004) (0)
EPINEPHRINE MODULATES TLR2 AND TLR4 EXPRESSION AFTER EX VIVO LPS STIMULATION: A BETA-EFFECT: 481 (2004) (0)
WHAT'S NEW IN SHOCK, NOVEMBER 2006? (2006) (0)
OF MICE AND MEN: THE INFLAMMATORY RESPONSE TO LIPOPOLYSACCHARIDE (LPS): 115 (2003) (0)
Sleep and Its Disorders: What You Should Know, by Robert (2001) (0)
Letter to the editor (2005) (0)
Dynamic Models of Disease Progression: Toward a Multiscale Model of Systemic Inflammation in Humans (2011) (0)
Decreased Cytokine Expression in Peripheral Blood Leukocytes of Patients With Severe Sepsis—Invited Critique (2002) (0)
Invited commentary (2005) (0)
Nutrition Support in the Surgery Patient (2005) (0)
lipopolysaccharide-treated rats during acute systemic inflammation in Differential gene expression profiling in whole blood (2015) (0)

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