Stuart H. Yuspa

Q: What Schools Are Affiliated With Stuart H. Yuspa

Stuart H. Yuspa is affiliated with the following schools: Kyushu University, University of Debrecen, University of Zurich

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Stuart H. Yuspa

Philosophy

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#6165

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#2220

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philosophy Degrees

Stuart H. Yuspa

Biology

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#7268

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Cell Biology

#129

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#134

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Biochemistry

#544

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#632

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biology Degrees

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Philosophy
Biology

Stuart H. Yuspa's Degrees

PhD Biochemistry University of California, Berkeley
Doctorate Medicine University of California, San Francisco

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Stuart H. Yuspa's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Calcium regulation of growth and differentiation of mouse epidermal cells in culture (1980) (1794)
Characterization of bullous pemphigoid antigen: A unique basement membrane protein of stratified squamous epithelia (1981) (618)
Expression of murine epidermal differentiation markers is tightly regulated by restricted extracellular calcium concentrations in vitro (1989) (580)
Altered differentiation of mouse epidermal cells treated with retinyl acetate in vitro. (1974) (444)
Identification of a major keratinocyte cell envelope protein, loricrin (1990) (436)
Isolation and short-term culture of primary keratinocytes, hair follicle populations and dermal cells from newborn mice and keratinocytes from adult mice for in vitro analysis and for grafting to immunodeficient mice (2008) (397)
c-fos is required for malignant progression of skin tumors (1995) (376)
Malignant conversion of mouse skin tumours is increased by tumour initiators and unaffected by tumour promoters (1983) (341)
The pathogenesis of squamous cell cancer: lessons learned from studies of skin carcinogenesis. (1998) (337)
Retinoic acid induces transforming growth factor-beta 2 in cultured keratinocytes and mouse epidermis. (1989) (319)
A survey of transformation markers in differentiating epidermal cell lines in culture. (1980) (318)
Protein Kinase Cδ Targets Mitochondria, Alters Mitochondrial Membrane Potential, and Induces Apoptosis in Normal and Neoplastic Keratinocytes When Overexpressed by an Adenoviral Vector (1999) (302)
Tumour promoter induces anchorage independence irreversibly (1979) (295)
Chemical carcinogenesis: from animal models to molecular models in one decade. (1988) (274)
Phorbol esters stimulate DNA synthesis and ornithine decarboxylase activity in mouse epidermal cell cultures (1976) (263)
The pathogenesis of squamous cell cancer: lessons learned from studies of skin carcinogenesis--thirty-third G. H. A. Clowes Memorial Award Lecture. (1994) (259)
Coordinate changes in gene expression which mark the spinous to granular cell transition in epidermis are regulated by protein kinase C (1993) (255)
Divergent responses in epidermal basal cells exposed to the tumor promoter 12-O-tetradecanoylphorbol-13-acetate. (1982) (251)
Expression of the BNLF-1 oncogene of Epstein-Barr virus in the skin of transgenic mice induces hyperplasia and aberrant expression of keratin 6 (1990) (250)
Transplacental effects of 3'-azido-2',3'-dideoxythymidine (AZT): tumorigenicity in mice and genotoxicity in mice and monkeys. (1997) (247)
Reduced skin tumor development in cyclin D1-deficient mice highlights the oncogenic ras pathway in vivo. (1998) (246)
Targeted expression of a dominant‐negative FGF receptor mutant in the epidermis of transgenic mice reveals a role of FGF in keratinocyte organization and differentiation. (1993) (245)
Mouse skin cells resistant to terminal differentiation associated with initiation of carcinogenesis (1981) (241)
An activated Harvey ras oncogene produces benign tumours on mouse epidermal tissue (1986) (238)
Bryostatin 1, an activator of protein kinase C, inhibits tumor promotion by phorbol esters in SENCAR mouse skin. (1987) (235)
Genetically null mice reveal a central role for epidermal growth factor receptor in the differentiation of the hair follicle and normal hair development. (1997) (234)
Loss of expression of transforming growth factor beta in skin and skin tumors is associated with hyperproliferation and a high risk for malignant conversion. (1993) (220)
Platinum-DNA adducts in leukocyte DNA correlate with disease response in ovarian cancer patients receiving platinum-based chemotherapy. (1987) (217)
Reconstitution of hair follicle development in vivo: determination of follicle formation, hair growth, and hair quality by dermal cells. (1993) (210)
Activation of the Epidermal Growth Factor Receptor Signal Transduction Pathway Stimulates Tyrosine Phosphorylation of Protein Kinase C (*) (1996) (201)
Transcriptional control of high molecular weight keratin gene expression in multistage mouse skin carcinogenesis. (1988) (200)
Development of murine epidermal cell lines which contain an activated rasHa oncogene and form papillomas in skin grafts on athymic nude mouse hosts. (1988) (196)
Involvement of protein kinase C delta (PKCdelta) in phorbol ester-induced apoptosis in LNCaP prostate cancer cells. Lack of proteolytic cleavage of PKCdelta. (2000) (195)
Synthetic peptides corresponding to keratin subunits elicit highly specific antibodies. (1984) (191)
Regulated expression of differentiation-associated keratins in cultured epidermal cells detected by monospecific antibodies to unique peptides of mouse epidermal keratins. (1987) (190)
Specific protein kinase C isozymes mediate the induction of keratinocyte differentiation markers by calcium. (1995) (188)
FVB/N mice: an inbred strain sensitive to the chemical induction of squamous cell carcinomas in the skin. (1993) (184)
A pilot project in molecular cancer epidemiology: determination of benzo[a]pyrene--DNA adducts in animal and human tissues by immunoassays. (1982) (166)
mtCLIC/CLIC4, an Organellular Chloride Channel Protein, Is Increased by DNA Damage and Participates in the Apoptotic Response to p53 (2002) (164)
EGFR enhances early healing after cutaneous incisional wounding. (2004) (164)
Isolation and utilization of epidermal keratinocytes for oncogene research. (1995) (163)
Retinoic acid-induced transglutaminase in mouse epidermal cells is distinct from epidermal transglutaminase. (1985) (162)
Targeted deletion of the TGF-beta 1 gene causes rapid progression to squamous cell carcinoma. (1994) (162)
Expression of an oncogenic rasHa gene in murine keratinocytes induces tyrosine phosphorylation and reduced activity of protein kinase C delta. (1993) (161)
Keratin gene expression in mouse epidermis and cultured epidermal cells. (1983) (160)
Quantitation of benzo(a)pyrene-deoxyguanosine adducts by radioimmunoassay. (1980) (157)
Chemotactic Activity of S100A7 (Psoriasin) Is Mediated by the Receptor for Advanced Glycation End Products and Potentiates Inflammation with Highly Homologous but Functionally Distinct S100A151 (2008) (156)
Quantitation of cis-diamminedichloroplatinum II (cisplatin)-DNA-intrastrand adducts in testicular and ovarian cancer patients receiving cisplatin chemotherapy. (1986) (150)
Early signals for keratinocyte differentiation: role of Ca2+-mediated inositol lipid metabolism in normal and neoplastic epidermal cells. (1988) (140)
The Organellular Chloride Channel Protein CLIC4/mtCLIC Translocates to the Nucleus in Response to Cellular Stress and Accelerates Apoptosis* (2004) (139)
Induction of papillomas with a high probability of conversion to malignancy. (1985) (139)
Optimized conditions for the growth of human epidermal cells in culture. (1980) (139)
Intracellular calcium alterations in response to increased external calcium in normal and neoplastic keratinocytes. (1989) (138)
In vivo regulation of murine hair growth: insights from grafting defined cell populations onto nude mice. (1993) (133)
p53 and Tumor Necrosis Factor α Regulate the Expression of a Mitochondrial Chloride Channel Protein* (1999) (132)
HIF-1alpha regulates epithelial inflammation by cell autonomous NFkappaB activation and paracrine stromal remodeling. (2008) (132)
Role of ornithine decarboxylase in epidermal tumorigenesis. (1995) (130)
Critical Aspects of Initiation, Promotion, and Progression in Multistage Epidermal Carcinogenesis (1993) (125)
Transforming growth factor beta 1 suppresses genomic instability independent of a G1 arrest, p53, and Rb. (1996) (122)
Differentiation of mouse keratinocytes is accompanied by PKC-dependent changes in AP-1 proteins. (1996) (121)
Chloride channels in cancer: Focus on chloride intracellular channel 1 and 4 (CLIC1 AND CLIC4) proteins in tumor development and as novel therapeutic targets. (2015) (119)
Bryostatin 1 protects protein kinase C-delta from down-regulation in mouse keratinocytes in parallel with its inhibition of phorbol ester-induced differentiation. (1994) (119)
Cutaneous chemical carcinogenesis. (1986) (117)
Protein kinase C regulates keratinocyte transglutaminase (TGK) gene expression in cultured primary mouse epidermal keratinocytes induced to terminally differentiate by calcium. (1994) (116)
Dynamic aspects of the supramolecular organization of intermediate filament networks in cultured epidermal cells. (1982) (116)
Contrasting actions of staurosporine, a protein kinase C inhibitor, on human neutrophils and primary mouse epidermal cells. (1988) (115)
Acute or chronic topical retinoic acid treatment of human skin in vivo alters the expression of epidermal transglutaminase, loricrin, involucrin, filaggrin, and keratins 6 and 13 but not keratins 1, 10, and 14. (1992) (114)
Comparison of two-stage epidermal carcinogenesis initiated by 7,12-dimethylbenz(a)anthracene or N-methyl-N'-nitro-N-nitrosoguanidine in newborn and adult SENCAR and BALB/c mice. (1981) (114)
The Suprabasal Expression of α6β4 Integrin Is Associated with a High Risk for Malignant Progression in Mouse Skin Carcinogenesis (1993) (111)
Specific epidermal protein markers are modulated during calcium-induced terminal differentiation (1983) (111)
Keratinocytes blocked in phorbol ester-responsive early stage of terminal differentiation by sarcoma viruses (1985) (111)
Aberrant expression during two‐stage mouse skin carcinogenesis of a type 147‐kDa keratin, k13, normally associated with terminal differentiation of internal stratified epithelia (1988) (109)
Phorbol ester tumor promoters induce epidermal transglutaminase activity. (1980) (108)
Properties of carcinogen altered mouse epidermal cells resistant to calcium-induced terminal differentiation. (1983) (107)
Protein Kinase C Negatively Regulates Akt Activity and Modifies UVC-induced Apoptosis in Mouse Keratinocytes* (2006) (107)
Transcripts encoding protein kinase C‐α, ‐ϵ, ‐ζ, and ‐ζ are expressed in basal and differentiating mouse keratinocytes in vitro and exhibit quantitative changes in neoplastic cells (1992) (106)
S100A7 enhances mammary tumorigenesis through upregulation of inflammatory pathways. (2011) (105)
Stimulated DNA synthesis in mouse epidermal cell cultures treated with 12-O-tetradecanoyl-phorbol-13-acetate. (1976) (105)
p53-mediated transcriptional activity increases in differentiating epidermal keratinocytes in association with decreased p53 protein. (1995) (104)
Definition by specific antisense oligonucleotides of a role for protein kinase Cα in expression of differentiation markers in normal and neoplastic mouse epidermal keratinocytes (1997) (103)
The tumor promoter, 12-O-tetradecanoylphorbol-13-acetate accelerates keratinocyte differentiation and stimulates growth of an unidentified cell type in cultured human epidermis. (1982) (102)
Functions of the POU domain genes Skn-1a/i and Tst-1/Oct-6/SCIP in epidermal differentiation. (1997) (102)
Antibodies elicited against cis-diamminedichloroplatinum(II)-modified DNA are specific for cis-diamminedichloroplatinum(II)-DNA adducts formed in vivo and in vitro. (1982) (100)
Proteomic Analysis of Vascular Endothelial Growth Factor-induced Endothelial Cell Differentiation Reveals a Role for Chloride Intracellular Channel 4 (CLIC4) in Tubular Morphogenesis* (2005) (100)
Signal Transduction for Proliferation and Differentiation in Keratinocytes (1988) (99)
Factors influencing calcium‐induced terminal differentiation in cultured mouse epidermal cells (1983) (98)
Chelation of intracellular Ca2+ inhibits murine keratinocyte differentiation in vitro (1995) (98)
Differentiation of cultured human epidermal keratinocytes at high cell densities is mediated by endogenous activation of the protein kinase C signaling pathway. (1998) (97)
The measurement of cisplatin-DNA adduct levels in testicular cancer patients. (1988) (96)
Biochemical evidence for keratinization by mouse epidermal cells in culture. (1978) (96)
Alterations in murine keratinocyte differentiation induced by activated rasHa genes are mediated by protein kinase C-alpha. (1994) (95)
Quantitative assay for carcinogen altered differentiation in mouse epidermal cells. (1980) (93)
Cholesterol sulfate activates multiple protein kinase C isoenzymes and induces granular cell differentiation in cultured murine keratinocytes. (1995) (93)
Modulation of tissue and epidermal transglutaminases in mouse epidermal cells after treatment with 12-O-tetradecanoylphorbol-13-acetate and/or retinoic acid in vivo and in culture. (1988) (93)
Two oncogenes, v-fos and v-ras, cooperate to convert normal keratinocytes to squamous cell carcinoma. (1990) (91)
Detection of carcinogen–DNA adducts by radioimmunoassay (1977) (91)
Targeted disruption of the epidermal growth factor receptor impairs growth of squamous papillomas expressing the v-ras(Ha) oncogene but does not block in vitro keratinocyte responses to oncogenic ras. (1997) (90)
Cultivation of murine hair follicles as organoids in a collagen matrix. (1987) (86)
Evaluation of platinum-DNA adduct levels relative to known prognostic variables in a cohort of ovarian cancer patients. (1990) (86)
Altered Regulation of TGF‐β1 and TGF‐α in Primary Keratinocytes and Papillomas Expressing v‐Ha‐ras (1991) (85)
Retinoic acid induces transglutaminase activity but inhibits cornification of cultured epidermal cells. (1982) (85)
Induction and autocrine receptor binding of transforming growth factor-beta 2 during terminal differentiation of primary mouse keratinocytes. (1990) (85)
Development of a rapid approach to identification of tyrosine phosphorylation sites: application to PKC delta phosphorylated upon activation of the high affinity receptor for IgE in rat basophilic leukemia cells. (1995) (85)
Src Family Kinases Phosphorylate Protein Kinase C δ on Tyrosine Residues and Modify the Neoplastic Phenotype of Skin Keratinocytes* (2002) (85)
Extracellular matrix receptors and mouse skin carcinogenesis: altered expression linked to appearance of early markers of tumor progression. (1992) (84)
Partial parallelism and partial blockade by bryostatin 1 of effects of phorbol ester tumor promoters on primary mouse epidermal cells. (1987) (83)
Genetic Ablation of Epidermal EGFR Reveals the Dynamic Origin of Adverse Effects of Anti-EGFR Therapy (2013) (83)
Cultivation and characterization of cells derived from mouse skin papillomas induced by an initiation-promotion protocol. (1986) (82)
The induction of epidermal transglutaminase and terminal differentiation by tumor promoters in cultured epidermal cells. (1983) (81)
Staurosporine induces protein kinase C agonist effects and maturation of normal and neoplastic mouse keratinocytes in vitro. (1991) (81)
Selenoproteins Are Essential for Proper Keratinocyte Function and Skin Development (2010) (78)
Keratinocyte growth factor receptor ligands induce transforming growth factor alpha expression and activate the epidermal growth factor receptor signaling pathway in cultured epidermal keratinocytes. (1994) (78)
Two-stage tumor promotion in mouse skin: an alternative interpretation. (1985) (78)
Activation of Cutaneous Protein Kinase Cα Induces Keratinocyte Apoptosis and Intraepidermal Inflammation by Independent Signaling Pathways (2003) (77)
Progress in cutaneous cancer research. (2002) (77)
Clonal growth of mouse epidermal cells in medium with reduced calcium concentration. (1981) (76)
Measurement of benzo(a)pyrene-DNA adducts by enzyme immunoassays and radioimmunoassay. (1981) (76)
Benzo(a)pyrene-DNA adduct formation and removal in mouse epidermis in vivo and in vitro: relationship of DNA binding to initiation of skin carcinogenesis. (1984) (76)
Gene from a Psoriasis Susceptibility Locus Primes the Skin for Inflammation (2010) (76)
Genetic deletion of p21WAF1 enhances papilloma formation but not malignant conversion in experimental mouse skin carcinogenesis. (1999) (75)
Reciprocal Modifications of CLIC4 in Tumor Epithelium and Stroma Mark Malignant Progression of Multiple Human Cancers (2007) (75)
Opposing activities of c-Fos and Fra-2 on AP-1 regulated transcriptional activity in mouse keratinocytes induced to differentiate by calcium and phorbol esters (1997) (75)
MyD88 and its divergent toll in carcinogenesis. (2013) (75)
Activator protein-1 activity regulates epithelial tumor cell identity. (2006) (75)
The growth of fetal mouse skin in cell culture and transplantation to F1 mice. (1970) (74)
TGFα stimulates growth of skin papillomas by autocrine and paracrine mechanisms but does not cause neoplastic progression (1988) (74)
Cutaneous chemical carcinogenesis: past, present, and future. (1976) (74)
Multiorgan transplacental and neonatal carcinogenicity of 3'-azido-3'-deoxythymidine in mice. (1999) (73)
The skin cancer chemotherapeutic agent ingenol-3-angelate (PEP005) is a substrate for the epidermal multidrug transporter (ABCB1) and targets tumor vasculature. (2010) (73)
The epidermal growth factor receptor is required to maintain the proliferative population in the basal compartment of epidermal tumors. (2000) (72)
Strain-dependent differences in malignant conversion of mouse skin tumors is an inherent property of the epidermal keratinocyte. (2004) (72)
The v‐ras oncogene inhibits the expression of differentiation markers and facilitates expression of cytokeratins 8 and 18 in mouse keratinocytes (1990) (72)
Autocrine transforming growth factor alpha is dispensible for v-rasHa-induced epidermal neoplasia: potential involvement of alternate epidermal growth factor receptor ligands. (1995) (71)
EGFR regulates the expression of keratinocyte-derived granulocyte/macrophage colony-stimulating factor in vitro and in vivo. (2010) (71)
Inducible cutaneous inflammation reveals a protumorigenic role for keratinocyte CXCR2 in skin carcinogenesis. (2009) (70)
Defects in transforming growth factor-beta signaling cooperate with a Ras oncogene to cause rapid aneuploidy and malignant transformation of mouse keratinocytes. (1999) (70)
Role of oncogenes and tumor suppressor genes in multistage carcinogenesis. (1994) (70)
Antisense suppression of the chloride intracellular channel family induces apoptosis, enhances tumor necrosis factor {alpha}-induced apoptosis, and inhibits tumor growth. (2005) (69)
Altered growth and differentiation of cultured mouse epidermal cells infected with oncogenic retrovirus: contrasting effects of viruses and chemicals. (1983) (69)
CXCR2 ligands and G-CSF mediate PKCα-induced intraepidermal inflammation (2006) (69)
Growth and differentiation of mouse epidermal cells in culture: effects of extracellular calcium. (1981) (68)
Protein Kinase Cα-Mediated Chemotaxis of Neutrophils Requires NF-κB Activity but Is Independent of TNFα Signaling in Mouse Skin In Vivo1 (2005) (68)
Malignant conversion of murine squamous papilloma cell lines by transfection with the fos oncogene (1988) (67)
Keratin gene expression in mouse skin tumors and in mouse skin treated with 12-O-tetradecanoylphorbol-13-acetate. (1985) (67)
Association of DNA strand breaks with accelerated terminal differentiation in mouse epidermal cells exposed to tumor promoters. (1985) (67)
Mouse skin tumor progression results in differential expression of retinoic acid and retinoid X receptors. (1995) (65)
Novel S100A7 (psoriasin)/S100A15 (koebnerisin) subfamily: highly homologous but distinct in regulation and function (2011) (65)
Selective changes in laminin adhesion and alpha 6 beta 4 integrin regulation are associated with the initial steps in keratinocyte maturation. (1996) (64)
Altered glycoprotein synthesis in mouse epidermal cells treated with retinyl acetate in vitro. (1974) (64)
Regulation of intracellular free calcium in normal murine keratinocytes. (1991) (63)
Subunit structure of the mouse epidermal keratin filament. (1979) (62)
The Use of cDNA Clones and Monospecific Antibodies as Probes to Monitor Keratin Gene Expression (1985) (61)
Association of resistance to terminal differentiation with initiation of carcinogenesis in adult mouse epidermal cells. (1985) (60)
Polyclonal antibodies to quantitate cis-diamminedichloroplatinum(II)--DNA adducts in cancer patients and animal models. (1985) (59)
Altered regulation of growth and expression of differentiation-associated keratins in benign mouse skin tumors. (1991) (59)
Molecular cloning of mouse epidermal cystatin A and detection of regulated expression in differentiation and tumorigenesis (1988) (59)
Growth factors specifically alter hair follicle cell proliferation and collagenolytic activity alone or in combination. (1990) (59)
Identification of control elements 3' to the human keratin 1 gene that regulate cell type and differentiation-specific expression. (1993) (57)
Effect of retinoic acid on cornified envelope formation: difference between spontaneous envelope formation in vivo or in vitro and expression of envelope competence. (1987) (57)
Synthesis of hyaluronic acid is decreased and synthesis of proteoglycans is increased when cultured mouse epidermal cells differentiate. (1986) (57)
Cross‐talk between epidermal growth factor receptor and protein kinase C during calcium‐induced differentiation of keratinocytes (2000) (57)
Transfection of the EJ rasHa gene into keratinocytes derived from carcinogen-induced mouse papillomas causes malignant progression (1986) (56)
TGF-β signalling is regulated by Schnurri-2 dependent nuclear translocation of CLIC4 and consequent stabilization of phospho Smad2–3 (2009) (56)
Formation and removal of specific acetylaminofluorene-DNA adducts in mouse and human cells measured by radioimmunoassay. (1979) (56)
CLIC4, an intracellular chloride channel protein, is a novel molecular target for cancer therapy. (2005) (54)
Mouse differentiation-specific keratins 1 and 10 require a preexisting keratin scaffold to form a filament network (1993) (54)
Reduced migration, altered matrix and enhanced TGFβ1 signaling are signatures of mouse keratinocytes lacking Sdc1 (2007) (54)
Mode of action of retinol. Involvement in glycosylation reactions of cultured mouse epidermal cells. (1979) (53)
Identification of filaggrin in cultured mouse keratinocytes and its regulation by calcium. (1983) (53)
Multistage carcinogenesis in the skin. (1996) (53)
Potassium mediation of calcium-induced terminal differentiation of epidermal cells in culture. (1983) (52)
CLIC4 mediates and is required for Ca2+-induced keratinocyte differentiation (2007) (52)
Changes in photo-aged human skin following topical application of all-trans retinoic acid. (1990) (51)
Intracellular chloride channels: critical mediators of cell viability and potential targets for cancer therapy. (2005) (51)
Loss of retinoic acid receptors in mouse skin and skin tumors is associated with activation of the ras(Ha) oncogene and high risk for premalignant progression. (1996) (51)
Suspension-induced murine keratinocyte differentiation is mediated by calcium. (1996) (51)
p53 gene dosage modifies growth and malignant progression of keratinocytes expressing the v-rasHa oncogene. (1994) (51)
Detection of pemphigoid antigen, pemphigus antigen, and keratin filaments by indirect immunofluorescence in cultured human epidermal cells. (1980) (51)
Aberrant Chloride Intracellular Channel 4 Expression Contributes to Endothelial Dysfunction in Pulmonary Arterial Hypertension (2014) (51)
A human epidermal differentiation-specific keratin gene is regulated by calcium but not negative modulators of differentiation in transgenic mouse keratinocytes. (1991) (51)
Targeted disruption of glutathione peroxidase 4 (GPx4) in mouse skin epithelial cells impairs postnatal hair follicle morphogenesis that is partially rescued through inhibition of COX-2 (2013) (50)
Inhibitors of the intracellular Ca(2+)-ATPase in cultured mouse keratinocytes reveal components of terminal differentiation that are regulated by distinct intracellular Ca2+ compartments. (1995) (50)
Induction of specific protein synthesis by phorbol esters in mouse epidermal cell culture. (1981) (50)
Inducible NOS-induced chloride intracellular channel 4 (CLIC4) nuclear translocation regulates macrophage deactivation (2012) (49)
Quantitative Proteomic Analysis of Myc-induced Apoptosis (2006) (48)
CXCR2 ligands and G-CSF mediate PKCalpha-induced intraepidermal inflammation. (2006) (48)
CRE DNA binding proteins bind to the AP-1 target sequence and suppress AP-1 transcriptional activity in mouse keratinocytes (1999) (48)
Initiator and promoter induced specific changes in epidermal function and biological potential. (1981) (47)
Overview of carcinogenesis: past, present and future. (2000) (47)
Ultraviolet light irradiation increases cellular diacylglycerol and induces translocation of diacylglycerol kinase in murine keratinocytes. (1992) (46)
CLIC4 is a tumor suppressor for cutaneous squamous cell cancer. (2012) (46)
Expression of interferon-β is associated with growth arrest of murine and human epidermal cells (1999) (45)
Expression profile of skin papillomas with high cancer risk displays a unique genetic signature that clusters with squamous cell carcinomas and predicts risk for malignant conversion (2007) (45)
Response of carcinogen-altered mouse epidermal cells to phorbol ester tumor promoters and calcium. (1987) (45)
Purified epidermal pentapeptide inhibits proliferation and enhances terminal differentiation in cultured mouse epidermal cells. (1986) (45)
Effect of culture conditions, cell type, and species of origin on the distribution of acetylated and deacetylated deoxyguanosine C-8 adducts of N-acetoxy-2-acetylaminofluorene. (1980) (45)
Identification and characterization of tumor initiating cells in human primary cutaneous squamous cell carcinoma (2011) (45)
Screening Compounds with a Novel High-Throughput ABCB1-Mediated Efflux Assay Identifies Drugs with Known Therapeutic Targets at Risk for Multidrug Resistance Interference (2013) (44)
Epidermal cell culture. (1980) (44)
The transcription factor CBFB suppresses breast cancer through orchestrating translation and transcription (2019) (44)
Retinyl acetate modulation of cell growth kinetics and carcinogen--cellular interaction in mouse epidermal cell cultures. (1977) (44)
Transformation of epidermal cells in culture. (1983) (43)
Tissue homeostasis and the control of the neoplastic phenotype in epithelial cancers. (2005) (43)
Epidermal growth factor receptor ligands regulate keratin 8 expression in keratinocytes, and transforming growth factor alpha mediates the induction of keratin 8 by the v-rasHa oncogene. (1993) (42)
RasGRP3 contributes to formation and maintenance of the prostate cancer phenotype. (2010) (42)
Short-term retinoic acid treatment increases in vivo, but decreases in vitro, epidermal transglutaminase-K enzyme activity and immunoreactivity. (1992) (41)
Regulation of epidermal transglutaminase activity and terminal differentiation by retinoids and phorbol esters. (1983) (41)
The contribution of epidermal stem cells to skin cancer (2007) (41)
S-Nitrosylation Regulates Nuclear Translocation of Chloride Intracellular Channel Protein CLIC4* (2010) (41)
Endogenous retroviruses promote homeostatic and inflammatory responses to the microbiota (2021) (41)
Overexpression of retinoic acid receptors alpha and gamma into neoplastic epidermal cells causes retinoic acid-induced growth arrest and apoptosis. (2001) (40)
Staurosporine induces a sequential program of mouse keratinocyte terminal differentiation through activation of PKC isozymes. (1996) (40)
Retinyl Acetate: Effect on Cellular Content of RNA in Epidermis in Cell Culture in Chemically Defined Medium (1973) (40)
Mouse keratinocytes derived from initiated skin or papillomas are resistant to DNA strand breakage by benzoyl peroxide: a possible mechanism for tumor promotion mediated by benzoyl peroxide. (1987) (40)
Highly homologous hS100A15 and hS100A7 proteins are distinctly expressed in normal breast tissue and breast cancer. (2009) (39)
Development of an in vitro analogue of initiated mouse epidermis to study tumor promoters and antipromoters. (1990) (39)
Relationship between the expression of differentiation‐specific keratins 1 and 10 and cell proliferation in epidermal tumors (1992) (39)
Effect of a tyrosine 155 to phenylalanine mutation of protein kinase cdelta on the proliferative and tumorigenic properties of NIH 3T3 fibroblasts. (2000) (39)
The black box illuminated: signals and signaling. (2012) (38)
RETINOIDS INHIBIT PROMOTER‐DEPENDENT PRENEOPLASTIC PROGRESSION IN MOUSE EPIDERMAL CELL LINES (1981) (38)
MODULATION OF TERMINAL DIFFERENTIATION AND RESPONSES TO TUMOR PROMOTERS BY RETINOIDS IN MOUSE EPIDERMAL CELL CULTURES (1981) (38)
Genomic structure and promoter analysis of PKC-δ (2003) (38)
Protein Kinase Cδ-mediated Phosphorylation of α6β4 Is Associated with Reduced Integrin Localization to the Hemidesmosome and Decreased Keratinocyte Attachment (2001) (38)
Spontaneous Ha‐ras Gene Activation in Cultured Primary Murine Keratinocytes: Consequences of Ha‐ras Gene Activation in Malignant Conversion and Malignant Progression (1989) (38)
Natural synchrony of newborn mouse epidermal cells in vitro. (1976) (38)
Milestones in skin carcinogenesis: the biology of multistage carcinogenesis. (2014) (37)
Skin tumorigenesis and Ki‐ras and Ha‐ras mutations in tumors from adult mice exposed in utero to 3′‐azido‐2′,3′‐dideoxythymidine (1998) (37)
Dissociation of tumor promoter-stimulated ornithine decarboxylase activity and DNA synthesis in mouse epidermis in vivo and in vitro by fluocinolone acetonide, a tumor-promotion inhibitor. (1977) (36)
Ultrasensitive enzymatic radioimmunoassay (USERIA) detects femtomoles of acetylaminofluorene-DNA adducts. (1980) (36)
Increased retinoic acid levels through ablation of Cyp26b1 determine the processes of embryonic skin barrier formation and peridermal development (2012) (36)
Maintenance of human skin on nude mice for studies of chemical carcinogenesis. (1979) (36)
Heterogeneity of [3H]phorbol 12,13-dibutyrate binding in primary mouse keratinocytes at different stages of maturation. (1985) (36)
A splice variant of alpha 6 integrin is associated with malignant conversion in mouse skin tumorigenesis. (1995) (36)
Cell protein cross-linking by erbstatin and related compounds. (1996) (35)
Mouse cell clones for improved quantitation of carcinogen-induced altered differentiation. (1985) (34)
Cell autonomous or systemic EGFR blockade alters the immune‐environment in squamous cell carcinomas (2016) (34)
Multigenic control of skin tumor susceptibility in SENCARA/Pt mice. (1998) (34)
Interaction of epidermal growth factor with basal and differentiating epidermal cells of mice resistant and sensitive to carcinogenesis. (1984) (34)
CLIC4, skin homeostasis and cutaneous cancer: Surprising connections (2007) (33)
The tumor promoter 12‐0‐tetradecanoylphorbol‐13‐acetate induces ornithine decarboxylase in proliferating basal cells but not in differentiating cells from mouse epidermis (1981) (33)
The mouse S100A15 ortholog parallels genomic organization, structure, gene expression, and protein-processing pattern of the human S100A7/A15 subfamily during epidermal maturation. (2006) (33)
Proto-oncogene expression during two-stage carcinogenesis in mouse skin. (1985) (33)
Correlation of initiating potency of skin carcinogens with potency to induce resistance to terminal differentiation in cultured mouse keratinocytes. (1985) (32)
Differential retinoic acid inhibition of ornithine decarboxylase induction by 12-O-tetradecanoylphorbol-13-acetate and by germicidal ultraviolet light. (1981) (32)
Effects of tumor promoters and steroidal anti-inflammatory agents on skin of newborn mice in vivo and in vitro. (1978) (32)
Characterization of a novel cyclin-dependent kinase 1 inhibitor, BMI-1026. (2003) (32)
RasGRP3, a Ras activator, contributes to signaling and the tumorigenic phenotype in human melanoma (2011) (32)
Induction of common patterns of polypeptide synthesis and phosphorylation by calcium and 12-O-tetradecanoylphorbol-13-acetate in mouse epidermal cell culture. (1987) (32)
The study of tumor promotion in a cell culture model for mouse skin--a tissue that exhibits multistage carcinogenesis in vivo. (1982) (31)
In vitro neoplastic transformation of mouse skin cells: morphology and ultrastructure of cells and tumors. (1974) (31)
Analysis of the rasH oncogene and its p21 product in chemically induced skin tumors and tumor-derived cell lines. (1987) (31)
Activity of diverse tumor promoters in a keratinocyte co-culture model of initiated epidermis. (1992) (31)
Reduced DNA repair in cultured melanocytes and nevus cells from a patient with xeroderma pigmentosum. (1989) (31)
The suprabasal expression of alpha 6 beta 4 integrin is associated with a high risk for malignant progression in mouse skin carcinogenesis. (1993) (30)
Indirect immunofluorescent localization of benzo[a]pyrene adducted to nucleic acids in cultured mouse keratinocyte nuclei. (1982) (30)
cis-Diamminedichloroplatinum (II)-DNA adduct formation in renal, gonadal, and tumor tissues of male and female rats. (1987) (30)
Benzo[alpha]pyrene diol epoxide I binds to DNA at replication forks. (1988) (30)
Enhanced malignant conversion of benign mouse skin tumors by cisplatin. (1990) (30)
Differences in the regulation of intracellular calcium in normal and neoplastic keratinocytes are not caused by ras gene mutations. (1991) (30)
Regulation of hair follicle development: an in vitro model for hair follicle invasion of dermis and associated connective tissue remodeling. (1993) (29)
Malignant conversion and metastasis of mouse skin tumors: a comparison of SENCAR and CD-1 mice. (1986) (29)
MET signaling in keratinocytes activates EGFR and initiates squamous carcinogenesis (2016) (28)
DNA adducts of cisplatin and carboplatin in tissues of cancer patients. (1988) (28)
Inhibition of tumor formation from grafted murine papilloma cells by treatment of grafts with staurosporine, an inducer of squamous differentiation. (1993) (28)
Differential regulation by anti-tumor-promoting 12-deoxyphorbol-13-phenylacetate reveals distinct roles of the classical and novel protein kinase C isozymes in biological responses of primary mouse keratinocytes. (1995) (27)
Xeroderma pigmentosum and D. N. A. repair. (1971) (27)
The binding of 7,12-dimethylbenz(A)anthracene to replicating and non-replicating DNA in cell culture. (1969) (27)
The high‐risk benign tumor: Evidence from the two‐stage skin cancer model and relevance for human cancer (2007) (27)
Hyperphosphorylation of cytokeratins by okadaic acid class tumor promoters in primary human keratinocytes. (1993) (27)
Expression of keratin genes in mouse epidermis and normal and malignantly transformed epidermal cells in culture. (1983) (27)
Sequential Changes in Gene Expression during Epidermal Differentiation (1988) (26)
A model for initiated mouse skin: suppression of papilloma but not carcinoma formation by normal epidermal cells in grafts on athymic nude mice. (1992) (26)
Direct quantification of polo-like kinase 1 activity in cells and tissues using a highly sensitive and specific ELISA assay (2009) (26)
Cutaneous Retinoic Acid Levels Determine Hair Follicle Development and Downgrowth* (2012) (26)
Activator protein 1 transcription factors are fundamental to v-rasHa-induced changes in gene expression in neoplastic keratinocytes. (2000) (26)
Staurosporine induces a complete program of terminal differentiation in neoplastic mouse keratinocytes via activation of protein kinase C. (1996) (26)
Dimethyl sulfoxide-induced enhancement of 7,12-dimethylbenz(a)anthracene metabolism and DNA binding in differentiating mouse epidermal cell cultures. (1976) (26)
A novel DLX3–PKC integrated signaling network drives keratinocyte differentiation (2017) (25)
Frequent codon 12 Ki‐ras mutations in mouse skin tumors initiated by N‐methyl‐N′‐nitro‐N‐nitrosoguanidine and promoted by mezerein (2000) (25)
A humanized stromal bed is required for engraftment of isolated human primary squamous cell carcinoma cells in immunocompromised mice (2011) (25)
The homeoprotein DLX3 and tumor suppressor p53 co-regulate cell cycle progression and squamous tumor growth (2015) (24)
Contrasting duration of inhibition of cell-cell communication in primary mouse epidermal cells by phorbol 12,13-dibutyrate and by bryostatin 1. (1988) (24)
Opposing functions of psoriasin (S100A7) and koebnerisin (S100A15) in epithelial carcinogenesis. (2013) (24)
Expression of transfected DNA by primary murine keratinocytes. (1988) (24)
New strains of inbred SENCAR mice with increased susceptibility to induction of papillomas and squamous cell carcinomas in skin (1997) (24)
Topical retinoic acid reduces skin papilloma formation but resistant papillomas are at high risk for malignant conversion. (1998) (23)
Development of an in vitro model to study carcinogen-induced neoplastic progression of initiated mouse epidermal cells. (1992) (23)
DNA adducts of cisplatin in nucleated peripheral blood cells and tissues of cancer patients. (1987) (22)
Protein kinase Cdelta-mediated phosphorylation of alpha6beta4 is associated with reduced integrin localization to the hemidesmosome and decreased keratinocyte attachment. (2001) (22)
Sensitivity to two-stage carcinogenesis of SENCAR mouse skin grafted to nude mice. (1982) (22)
Spontaneous skin erosions and reduced skin and corneal wound healing characterize CLIC4(NULL) mice. (2012) (22)
Genomic structure and promoter analysis of PKC-delta. (2003) (21)
Aluminum fluoride stimulates inositol phosphate metabolism and inhibits expression of differentiation markers in mouse keratinocytes (1991) (21)
Loss of syndecan‐1 is associated with malignant conversion in skin carcinogenesis (2010) (21)
Strontium induces murine keratinocyte differentiation in vitro in the presence of serum and calcium (1993) (21)
Expression of interferon-beta is associated with growth arrest of murine and human epidermal cells. (1999) (21)
Magnesium and phosphate enrichment of culture medium stimulates the proliferation of epidermal cells from newborn and adult mice (1990) (21)
A PMLRARA transgene results in a retinoid-deficient phenotype associated with enhanced susceptibility to skin tumorigenesis. (2003) (19)
Differential regulation of integrins and extracellular matrix binding in epidermal differentiation and squamous tumor progression. (1996) (19)
Altered regulation of TGF-beta 1 and TGF-alpha in primary keratinocytes and papillomas expressing v-Ha-ras. (1991) (19)
CLIC4 and Schnurri-2: A dynamic duo in TGFβ signaling with broader implications in cellular homeostasis and disease (2010) (19)
v‐Ha‐ras‐induced mouse skin papillomas exhibit aberrant expression of keratin K13 as do their 7,12‐dimethylbenz[a]anthracene/12‐O‐tetradecanoylphorbol‐13‐acetate‐induced analogues (1991) (18)
Identification of differentially expressed genes in chemically induced skin tumors (1997) (18)
Involvement of Protein Kinase C δ (PKCδ) in Phorbol Ester-induced Apoptosis in LNCaP Prostate Cancer Cells (2000) (18)
Involvement of Protein Kinase C d ( PKC d ) in Phorbol Ester-induced Apoptosis in LNCaP Prostate Cancer Cells (2000) (17)
Replication of DNA after binding of the carcinogen 7,12-dimethylbenz [a] anthracene. (1970) (17)
Chemical carcinogenesis studies in mouse epidermal cell cultures. (1980) (17)
Keratin expression in mouse epidermal tumors. (1989) (17)
Cytogenetic profile of mouse skin tumors induced by the viral Harvey-ras gene. (1988) (17)
Transforming growth factor beta1 enhances tumor promotion in mouse skin carcinogenesis. (2010) (16)
Cytogenetic evidence for gene amplification in mouse skin carcinogenesis. (1986) (16)
Modulation of Hair Follicle Cell Proliferation and Collagenolytic Activity by Specific Growth Factors a (1991) (16)
Tumorigenic suppression of a human cutaneous squamous cell carcinoma cell line in the nude mouse skin graft assay. (1992) (16)
A comparison of interfollicular and hair follicle derived cells as targets for the v-rasHa oncogene in mouse skin carcinogenesis. (1991) (16)
SENCAR mouse skin tumors produced by promotion alone have A to G mutations in codon 61 of the c-rasHa gene. (1994) (15)
Tumor promoters induce the synthesis of a secreted glycoprotein in mouse skin and cultured primary mouse epidermal cells. (1981) (15)
Detection of differential fetal and adult expression of chloride intracellular channel 4 (CLIC4) protein by analysis of a green fluorescent protein knock-in mouse line (2014) (15)
Specific quantification of mouse and human keratin proteins by radioimmunoassay. (1980) (14)
GERMICIDAL ULTRAVIOLET LIGHT INDUCES ORNITHINE DECARBOXYLASE IN MOUSE EPIDERMAL CELLS AND MODIFIES THE INDUCTION CAUSED BY PHORBOL ESTER TUMOR PROMOTERS (1980) (14)
Protein Kinase C -Mediated Chemotaxis of Neutrophils Requires NF- B Activity but Is Independent of TNF Signaling in Mouse Skin In Vivo (2005) (14)
Molecular and cellular basis for tumor promotion in mouse skin. (1983) (13)
Consequences of exposure to initiating levels of carcinogens in vitro and in vivo: altered differentiation and growth, mutations, and transformation. (1989) (13)
The erbstatin analogue methyl 2,5-dihydroxycinnamate cross-links proteins and is cytotoxic to normal and neoplastic epithelial cells by a mechanism independent of tyrosine kinase inhibition. (1995) (13)
Inhibition of epidermal terminal differentiation and tumour promotion by retinoids. (1985) (13)
In vitro cultivation of a chemically induced epidermal carcinoma: establishment of three cell lines and isolation of murine leukemia virus. (1973) (13)
Role of Retinoic Acid Receptor-γ in DNA Damage-Induced Necroptosis (2019) (13)
An Anchor for Tumor Cell Invasion (2005) (12)
Hair follicle development and hair growth from defined cell populations grafted onto nude mice. (1995) (12)
The role of growth factors in mouse skin tumor promotion and premalignant progression. (1995) (12)
Repair of daughter strand gaps in nascent DNA from mouse epidermal cells treated with dihydrodiol epoxide derivatives of benzo[a]pyrene. (1979) (12)
Immortalized rat whisker dermal papilla cells cooperate with mouse immature hair follicle buds to activate type IV procollagenases in collagen matrix coculture: correlation with ability to promote hair follicle development in nude mouse grafts. (1995) (12)
Quantitation by electron microscopy of the binding of highly specific antibodies to benzo[a]pyrene-DNA adducts. (1985) (11)
AZT IS A GENOTOXIC TRANSPLACENTAL CARCINOGEN IN ANIMAL MODELS: 52 (1997) (10)
Inhibition of 12-O-tetradecanoylphorbol-13-acetate induction of epidermal transglutaminase activity by protease inhibitors. (1983) (10)
The malignant conversion step of mouse skin carcinogenesis. (1990) (10)
Genetic ablation of cyclooxygenase-2 in keratinocytes produces a cell-autonomous defect in tumor formation. (2012) (9)
ALTERATIONS IN EPIDERMAL DIFFERENTIATION IN SKIN CARCINOGENESIS (1985) (9)
Factors mediating the interactions between epidermal and dermal cells in skin grafts that might be important for hair follicle development. (1995) (9)
Skin calcium-binding protein is a parvalbumin of the panniculus carnosus. (1986) (9)
Sensitivity of subpopulations of mouse skin papillomas to malignant conversion by urethane or 4-nitroquinoline N-oxide. (1990) (9)
Elevating CLIC4 in Multiple Cell Types Reveals a TGF-β Dependent Induction of a Dominant Negative Smad7 Splice Variant (2016) (9)
The Binding of Benz [a] anthracene to Replicating and NonReplicating DNA in Cell Culture (1970) (8)
Local anesthetics inhibit induction of ornithine decarboxylase by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate. (1980) (8)
Involvement of Protein Kinase C d (PKC d ) in Phorbol Ester-induced Apoptosis in LNCaP Prostate Cancer Cells LACK OF PROTEOLYTIC CLEAVAGE OF PKC d * (2000) (8)
Mechanisms of initiation and promotion in mouse epidermis. (1984) (8)
Biological activity of the bryostatin analog Merle 23 on mouse epidermal cells and mouse skin (2016) (8)
Differences in the regulation of phosphatidylinositol‐specific phospholipase C in normal and neoplastic keratinocytes (1994) (8)
Organ culture of rodent prostate. Effects of polyamines and testosterone. (1976) (8)
The human promyelocytic leukemia protein is a tumor suppressor for murine skin carcinogenesis (2009) (8)
Application of cantharidin or 12-O-tetradecanoylphorbol-13-acetate on mouse epidermis induces a cell population shift that causes altered keratin distribution. (1994) (8)
Keratinocyte p38δ loss inhibits Ras‐induced tumor formation, while systemic p38δ loss enhances skin inflammation in the early phase of chemical carcinogenesis in mouse skin (2016) (8)
HIF-1 (cid:1) regulates epithelial inﬂammation by cell autonomous NF (cid:2) B activation and paracrine stromal remodeling (2008) (7)
Topical Application of a Dual ABC Transporter Substrate and NF-κB Inhibitor Blocks Multiple Sources of Cutaneous Inflammation in Mouse Skin. (2019) (7)
Purification, crystallization and preliminary X-ray diffraction of human S100A15. (2006) (6)
An antibody to p53 recognizes soluble keratins in epidermal keratinocyte cultures under differentiating, but not proliferating, conditions. (1997) (6)
IDENTIFICATION OF CARCINOGEN-DNA ADDUCTS BY IMMUNOASSAYS (1983) (6)
Inhibition of calcium-induced terminal differentiation of epidermal cells by ouabain and A23187. (1983) (6)
Comparison of octahydromezerein and mezerein as protein kinase C activators and as mouse skin tumor promoters. (1989) (6)
Role of differentiation in determining responses of epidermal cells to phorbol esters. (1982) (5)
Restoration of differentiation and suppression of tumorigenicity in somatic cell hybrids of human squamous carcinoma cells and keratinocytes. (1994) (5)
Nonmelanoma skin cancer, melanomas, warts, and viral oncogenesis. (1984) (5)
DNA adduct formation and removal in N-acetoxy-2-acetylaminofluorene-exposed cultured cells and in organs from rats fed 2-acetylaminofluorene. (1983) (5)
Loss of DLX3 tumor suppressive function promotes progression of SCC through EGFR-ERBB2 pathway (2021) (5)
Head and neck squamous cancer progression is marked by CLIC4 attenuation in tumor epithelium and reciprocal stromal upregulation of miR-142-3p, a novel post-transcriptional regulator of CLIC4 (2019) (5)
A procedure for the culture of hair follicles as functionally intact organoids. (1988) (5)
Cellular and molecular mechanisms of carcinogenesis in lining epithelia. (1986) (4)
Modulation of Epidermal Differentiation by Retinoids1 (1991) (4)
Biomonitoring of cisplatin-DNA adducts in cancer patients receiving cisplatin chemotherapy. (1986) (4)
Alterations in epidermal functions resulting from exposure to initiators and promoters of carcinogenesis. (1983) (4)
Tumor Promotion: A Problem of Differential Responses of Normal and Neoplastic Cells to Trophic Stimuli (1987) (4)
Aberrant differentiation in mouse skin carcinogenesis. (1988) (4)
Cancer. An anchor for tumor cell invasion. (2005) (4)
Detection and quantitation of acetylated and deacetylated N-2-fluorenylacetamide-DNA adducts by radioimmunoassay. (1981) (4)
Susceptibility determinants for mouse epidermal carcinogenesis. (1982) (4)
Targeted deletion of the TGF-pi gene causes rapid progression to squamous cell carcinoma (2007) (3)
Organ specificity and tumor promotion. (1983) (3)
Modeling the Transcriptional Consequences of Epidermal Growth Factor Receptor Ablation in Ras-Initiated Squamous Cancer (2011) (3)
Regulated synthesis of low-molecular-weight antigens in keratinocyte cell cultures. (1986) (3)
Activation of the rasHa gene in urethane-initiated papillomas induced by protocols with high and low frequencies of malignant conversion. (1991) (3)
Milestones in Skin Carcinogenesis: The Biology of (2014) (3)
T-Cell Deletion of MyD88 Connects IL17 and IκBζ to RAS Oncogenesis (2019) (3)
Functionally Distinct S100A15 Inflammation with Highly Homologous but Glycation End Products and Potentiates Mediated by the Receptor for Advanced Chemotactic Activity of S100A7 (Psoriasin) Is (2008) (2)
Cell Receptors as Mediators of Metabolic Signals (1989) (2)
Interacting signaling pathways in the pathogenesis of squamous cell carcinoma. (2000) (2)
Inhibitory Effect of Pyridoxine Deficiency on Growth of a Transplanted Tumor in Rats.∗ (1966) (2)
Transforming Growth Factor ÃŸlSuppresses Genomic Instability Independent of a G! Arrest, p53, and Rb (2006) (2)
Abstract 18: Targeted epidermal ablation of EGFR causes local and systemic inflammation (2010) (2)
DimethylSulfoxide-inducedEnhancementof 7,12-Dimethylbenz(a)anthracene Metabolismand DNA Bindingin DifferentiatingMouse EpidermalCell Cultures (1976) (2)
Properties of murine pelage hair follicles in monolayer and collagen matrix cultures. (1991) (2)
The Cultured Murine Epidermal Keratinocyte and Studies of Differentiation (1988) (2)
Terminal differentiation assay for chemical carcinogenesis in mouse epidermal cells. Abstr. (1980) (2)
Carcinogenesis but not Malignant Conversion in Experimental Mouse Skin Enhances Papilloma FormationWAF 1 Genetic Deletion of p 21 Updated (2000) (2)
Science Signaling Podcast for 21 June 2016: MET and skin cancer (2016) (1)
Strand breaks in mouse epidermal DNA are associated with phorbol ester induced differentiation (1985) (1)
Interacting Signaling Pathways in Mouse Skin Tumor Initiation and Progression (2011) (1)
Polyclonal Antibodies to Quantitate Cis (2016) (1)
Microenvironment and Immunology S 100 A 7 Enhances Mammary Tumorigenesis through Upregulation of In fl ammatory Pathways (2012) (1)
Detection of differential fetal and adult expression of chloride intracellular channel 4 (CLIC4) protein by analysis of a green fluorescent protein knock-in mouse line (2014) (1)
Abstract 1777: The skin cancer chemotherapeutic agent PEP005 is a substrate for the epidermal multidrug transporter (ABCB1) and targets tumor vasculature (2010) (1)
Molecular intervention of retinol in glycosylation reactions in mouse epidermal cells in culture (1977) (1)
In vitro comparisons of SENCAR and BALB/c primary epidermal cells. (1986) (1)
The suprabasal expression of a6β4 integrin predicts a high risk for malignant progression in mouse skin carcinogenesis (1993) (1)
Analysis of v‐Ha‐ras and v‐fos oncogene transduction into a mouse epidermal cell line with “initiated” phenotype in culture but normal skin phenotype in vivo (1995) (1)
Effects of a steroidal anti inflammatory agent on DNA synthesis in adult and newborn mouse epidermis (1976) (1)
Antibodies elicited against cis-diamminedichloroplatinum ( II )-modified DNA are specific for cis-diamminedichloro-platinum ( II )-DNA adducts formed in vivo and in vitro ( antitumor drug / enzyme-linked immunosorbent assay / L 1210 cells / tumor-bearing mice ) (1)
RAS induced senescence of skin keratinocytes is mediated through Rho‐associated protein kinase (ROCK) (2021) (1)
Retinoids and Skin Carcinogenesis (1985) (1)
The oxidoreductase CLIC4 is required to maintain mitochondrial function and resistance to exogenous oxidants in breast cancer cells (2022) (1)
Properties of a SENCAR mouse epidermal cell line and effects of oncogene introduction (1990) (0)
Chloride Intracellular Channel Protein-4 In The Vascular Dysfunction Of Pulmonary Arterial Hypertension (2012) (0)
Epidermal Cell Lines in Culture A Survey of Transformation Markers in Differentiating Updated (2006) (0)
The transcription factor CBFB suppresses breast cancer through orchestrating translation and transcription (2019) (0)
Keratinocytes-induced Changes in Gene Expression in Neoplastic Haras v-Activator Protein 1 Transcription Factors Are Fundamental to Updated (2000) (0)
Cancer esearch cular and Cellular Pathobiology GRP 3 Contributes to Formation and Maintenance of the R state Cancer Phenotype (2010) (0)
Abstract 1924: miR-142-3p is a candidate mediator of chloride intracellular channel 4 (CLIC4) loss during squamous cancer progression (2016) (0)
Transforming growth factor b 1 enhances tumor promotion in mouse skin carcinogenesis (2010) (0)
Atlas of Genetics and Cytogenetics in Oncology and Haematology (2010) (0)
41 – Epithelial Skin Cancer (2015) (0)
Abstract #2222: Syndecan-1 is required for formation of cutaneous squamous cell carcinomas after chemical carcinogenesis. (2009) (0)
Participation of Fos and Jun in multistage carcinogenesis (2017) (0)
Retinoic acidinduces transforming growth factor-fl2 in cultured keratinocytes andmouse epidermis (1989) (0)
HL-1 Innate resistance, inflammation, and carcinogenesis (2010) (0)
Abstract 1482: Autocrine IL-1α mediates NF-κB activation by oncogenic ras in keratinocytes (2010) (0)
Effects of exposure to benzo(a)pyrene-diol-epoxide-I on DNA replication in C3H 10T1/2 cells (1986) (0)
Abstract 5029: RasGRP3- a new therapeutic target in human melanoma (2010) (0)
Abstract 2454: Comparison of the activity of the bryostatin derivative Merle 23 with that of bryostatin 1 and phorbol ester in mouse epidermal cells. (2013) (0)
‘Going green’ against skin cancer (2010) (0)
Abstract 3975: CLIC4 induces a Smad7 variant to enhance TGF-β signaling in keratinocytes (2010) (0)
Molecular mechanisms of malignant conversion in skin carcinogenesis. (1989) (0)
KGF induces TGFα expression and activates the EGF receptor signaling pathway to alter keratinocyte growth and differentiation in vitro (1993) (0)
105 Keratinocyte p38α loss results in increased tumor initiation, decreased malignant progression, and altered tumor type specification during two-stage chemical carcinogenesis in murine skin (2016) (0)
Montagna Symposium 2011: 60th Anniversary--Advances in Science and Medicine Catalyzed by Pioneering Skin Research. (2012) (0)
CLIC4/mtCLIC, a p53-Regulated Organellar Chloride Channel Protein, Translocates to the Nucleus Following Apoptotic Stimuli and Alters Nuclear Chloride Content and pH (2004) (0)
From the Editors (0)
Chapter 18 Integumentary System–An Overview (1980) (0)
Abstract 5165: ADAM17: a common effector for RAS and MET-driven transformation of primary keratinocytes (2016) (0)
Regulating skin structure and function. A review of current knowledge of the mechanisms for regulation of cell growth and wound healing in skin (1995) (0)
Loss of TGF-ß Expression is a Critical Component of Malignant Progression in Multistage Carcinogenesis of the Mouse Epidermis (1993) (0)
Factors influencing interactions of epidermal growth factor (egf) with mouse epidermal cells in culture. Abstr. (1983) (0)
156 Conditional expression of oncogenic Kras and Hras alleles in mouse keratinocytes reveals a dose dependent requirement for tumor formation (2019) (0)
142 Keratinocyte p38α ablation reveals a context-dependent regulation of tumor initiation, tumor type specification, maintenance, and malignant progression in several models of mouse skin tumorigenesis (2019) (0)
A quantitative assay for carcinogen-induced altered differentiation in epidermal cell cultures (1980) (0)
Development of a vector for achievement of gene expression in the epidermis of transgenic animals (1993) (0)
A process for the treatment of hyperproliferative epithelial lesions by topical application of hydroxylated aromatic protein crosslinking compounds (1996) (0)
Abstract 1064: The combined activation of MET signaling and PKCα is sufficient to induce tumors in mouse skin. (2013) (0)
From the editors (0)
Abstract 1042: CLIC4 is incorporated into extracellular vesicles of murine breast cancer cells and may influence metastatic burden (2017) (0)
From the Editors (0)
Effect of Retinoic Acid on Cornified Envelope Forl 11 ation : Difference Between Spontaneous Envelope Forl 11 ation In Vivo or In Vitro and Expression of Envelope COl 11 petence (2010) (0)
Epidermal Cells Effects of Phorbol Ester Tumor Promoters on Primary Mouse Partial Parallelism and Partial Blockade by Bryostatin 1 of Updated (2006) (0)
Tetradecanoylphorbol-13-acetate O Tumor Promoter 12-Divergent Responses in Epidermal Basal Cells Exposed to the Updated Version (2006) (0)
LB793 Rho-associated protein kinase (ROCK) controls cellular homeostasis of mouse primary keratinocytes (2016) (0)
Abstract 4923: MyD88 and IL-17 have essential local and systemic functions in promoting tumors on mouse skin (2017) (0)
O6. Nitric oxide directly regulates nuclear translocation of chloride intracellar channel CLIC4 (2008) (0)
From the editors (0)
Abstract 5635: Development of a high-throughput cell and fluorescent image-based ABCB1-mediated efflux assay for screening inhibitors of ABCB1. (2013) (0)
Targeted removal of the selenocysteine tRNA gene (trsp) in epidermis modulates skin function and development. (2008) (0)
Transgene Results in a Retinoid-deficient Phenotype Associated with Enhanced Susceptibility to Skin Tumorigenesis 1 (2003) (0)
of SENCARMouse Skin Grafted to Nude Mice1 (1982) (0)
Abstract 388: mS100a7a15 enhances mammary tumor growth and metastasis by recruiting tumor associated macrophages (2012) (0)
Murine models of HRAS-mediated cutaneous skeletal hypophosphatemia syndrome suggest bone as the FGF23 excess source (2023) (0)
Genes involved in initiation and promotion in skin carcinogenesis (1992) (0)
1095 Evaluating IKK 16 and ACHP as anti-inflammatory agents for treatment of skin inflammation: In vitro and in vivo (2018) (0)
Stem Cells in Nonmelanoma Skin Cancer (2004) (0)
Abstract 1418: CLIC4 regulates carcinogenesis in a TGF-β context-dependent manner. (2013) (0)
iNOS-induced CLIC4 nuclear translocation regulates macrophage deactivation and TGF-β signaling (2012) (0)
Abstract 1081: Rapamycin is a chemopreventive and chemotherapeutic agent for ras-driven epidermal squamous cell carcinoma: evidence from mouse models. (2013) (0)
Ninth aspen cancer conference: Mechanisms of toxicity and carcinogenesis (1995) (0)
288 DLX3- A Homeobox protein modulating regulatory networks and signaling pathways crucial for epidermal homeostasis (2019) (0)
Keratin Production as a Marker for Normal Differentiation in Mouse Epidermal Cell Cultures (1978) (0)
318 Homeostatic balance of DLX3-PKC interplay controls keratinocyte cell cycle, differentiation, and inflammation-related pathways (2016) (0)
A change at the helm (1992) (0)
Selective detachment of a tetraploid subline of primary keratinocytes after treatment with the tumor promoter 12-0-tetradecanoylphorbol-13-acetate. (1988) (0)
Cover Image, Volume 60, Issue 12 (2021) (0)
Epidermal Tumors the Proliferative Population in the Basal Compartment of The Epidermal Growth Factor Receptor Is Required to Maintain Updated (2000) (0)
Host CLIC4 expression in the tumor microenvironment is essential for breast cancer metastatic competence (2022) (0)
Abstract 1642: Bryostatin 1 and the simplified analog Merle 23 have similar and opposing properties on mouse epidermal cells and mouse skin (2014) (0)
Signaling Pathways Intraepidermal Inflammation by Independent Induces Keratinocyte Apoptosis and a Activation of Cutaneous Protein Kinase C (2003) (0)
Mascia Adverse Effects of Anti-EGFR Therapy Genetic Ablation of Epidermal EGFR Reveals the Dynamic Origin of (2013) (0)
Thirteenth Aspen Cancer Conference: Workshop on Mechanisms of Toxicity and Carcinogenesis (1999) (0)
Dissociation oftumorpromoter-stimulated ornithine decarboxylase activity andDNA synthesis inmouseepidermis invivoandinvitro byfluocinolone acetonide, atumor-promotion inhibitor (chemical carcinogenesis/polyamines/steroids) ULRIKELICHTI*, THOMASJ.SLAGAt, THERESABEN*,ELROYPATTERSON*, HENRYHENNINGS*, A (1977) (0)
Regulating normal skin function by polypeptide growth factors (1994) (0)
Localanesthetics inhibit induction ofornithine decarboxylase bythe tumorpromoter 12-O-tetradecanoylphorbol 13-acetate (polyamines/lidocaine/tetracaine/procaine) (1980) (0)
Role of Ornithine Decarboxylase in Epidermal Tumorigenesis 1 (2006) (0)
043 Loss of DLX3 tumor suppressive function is associated with poor prognosis in human SCCs (2021) (0)
Bryostatin 1 in Primary Mouse Epidermal Cells by Phorbol 12 , 13-Dibutyrate Contrasting Duration of Inhibition of Cell-Cell Communication (2006) (0)
Abstract 3949: S100A7 modulates growth factor-mediated signaling in estrogen receptor negative breast cancer (2010) (0)
RAS oncogene signal strength regulates matrisomal gene expression and tumorigenicity of mouse keratinocytes. (2022) (0)
127 ROCK inhibition reduces Ras-induced senescence in primary mouse keratinocytes (2020) (0)
Toll-Like Receptor Agonist Induces IFN-gþIL-17þ Polyfunctional T Cells That Mediate Rejection of Murine Tumors (2012) (0)
Frequent codon 12 Ki-ras mutations in mouse skin tumors initiated by N-methyl-N′-nitro-N-nitrosoguanidine and promoted by mezerein†This article is a US Government work and, as such, is in the public domain in the United States of America. (2000) (0)

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