Stephen J. H. Ashcroft
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Stephen J. H. Ashcroftbiology Degrees
Biology
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Molecular Biology
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Biochemistry
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Biology
Stephen J. H. Ashcroft's Degrees
- Bachelors Biochemistry University of Oxford
Why Is Stephen J. H. Ashcroft Influential?
(Suggest an Edit or Addition)Stephen J. H. Ashcroft's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Glucose induces closure of single potassium channels in isolated rat pancreatic β-cells (1984) (1095)
- Properties and functions of ATP-sensitive K-channels. (1990) (696)
- AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic beta cells, and may regulate insulin release. (1998) (427)
- The pentose cycle and insulin release in mouse pancreatic islets. (1972) (299)
- Interrelationship of islet metabolism, adenosine triphosphate content and insulin release. (1973) (281)
- The sulfonylurea receptor. (1992) (267)
- The ATP‐sensitivity of K+ channels in rat pancreatic B‐cells is modulated by ADP (1986) (245)
- Organelle Selection Determines Agonist-specific Ca2+ Signals in Pancreatic Acinar and β Cells* (2004) (219)
- Glucose metabolism in mouse pancreatic islets. (1970) (202)
- Identification of the high-affinity tolbutamide site on the SUR1 subunit of the K(ATP) channel. (1999) (193)
- The Insulin Gene Promoter: A Simplified Nomenclature (1995) (174)
- Promiscuous coupling between the sulphonylurea receptor and inwardly rectifying potassium channels (1996) (169)
- NAADP A New Second Messenger for Glucose-Induced Ca2+ Responses in Clonal Pancreatic β Cells (2003) (167)
- Acute effects of fatty acids on insulin secretion from rat and human islets of Langerhans. (2002) (155)
- Metabotropic glutamate and GABAB receptors contribute to the modulation of glucose-stimulated insulin secretion in pancreatic beta cells (2002) (150)
- Properties of single potassium channels modulated by glucose in rat pancreatic beta‐cells. (1988) (142)
- Presence and possible role of calcium‐dependent regulator (calmodulin) in rat islets of langerhans (1979) (128)
- Isoforms of endoplasmic reticulum Ca(2+)-ATPase are differentially expressed in normal and diabetic islets of Langerhans. (1996) (123)
- Insulin Secretion Mechanisms and Glucose Metabolism in Isolated Islets (1972) (114)
- Identification of functional ionotropic glutamate receptor proteins in pancreatic β‐cells and in islets of Langerhans (1995) (99)
- Sequence variants of the sarco(endo)plasmic reticulum Ca2+-transport ATPase 3 gene (SERCA3) in Caucasian Type II diabetic patients (UK Prospective Diabetes Study 48) (1999) (92)
- Enzymes of glucose metabolism in normal mouse pancreatic islets. (1970) (89)
- Control of insulin gene expression by glucose. (1992) (88)
- Molecular structure of the glibenclamide binding site of the β‐cell KATP channel (2001) (85)
- Pharmacological characterisation of the antihyperglycaemic properties of Tinospora crispa extract. (1998) (84)
- Sulfonylureas enhance exocytosis from pancreatic beta-cells by a mechanism that does not involve direct activation of protein kinase C. (1998) (82)
- Protein kinase C in beta-cells: expression of multiple isoforms and involvement in cholinergic stimulation of insulin secretion (1996) (82)
- The effect of sugars on (pro)insulin biosynthesis. (1978) (81)
- Glucoreceptor mechanisms and the control of insulin release and biosynthesis (2005) (79)
- Evidence for the participation of calmodulin in stimulus-secretion coupling in the pancreatic beta-cell. (1980) (78)
- Insulin : molecular biology to pathology (1992) (77)
- Antidiabetic effects of Tinospora crispa in rats. (1989) (67)
- Isolation of human pancreatic islets capable of releasing insulin and metabolising glucose in vitro. (1971) (64)
- Effects of 2‐ketoisocaproate on insulin release and single potassium channel activity in dispersed rat pancreatic beta‐cells. (1987) (58)
- Concentration of adenosine 3':5'-cyclic monophosphate in mouse pancreatic islets measured by a protein-binding radioassay. (1973) (55)
- The dependence on intracellular ATP concentration of ATP‐sensitive K‐channels and of Na,K‐ATPase in intact HIT‐T15β‐cells (1989) (54)
- Glucose regulates preproinsulin messenger RNA levels in a clonal cell line of simian virus 40‐transformed B cells (1987) (54)
- The β-Cell KATP Channel (2000) (52)
- Cyclic nucleotide phosphodiesterase activity in normal mouse pancreatic islets (1972) (51)
- Superoxide Dismutase Activity in Lymphocytes and Polymorphonuclear Cells of Diabetic Patients (1997) (51)
- The β-Cell K ATP Channel (2000) (50)
- A novel pancreatic β‐cell isoform of calcium/calmodulin‐dependent protein kinase II (β 3 isoform) contains a proline‐rich tandem repeat in the association domain (1995) (49)
- The effect of nickel on secretory systems. Studies on the release of amylase, insulin and growth hormone. (1974) (46)
- Insulin release from human pancreatic islets in vitro (1980) (46)
- Effect of adrenal steroids on insulin release from cultured rat islets of Langerhans (1986) (46)
- Characteristics of the adenohypophyseal Ca2+-phospholipid-dependent protein kinase (1984) (45)
- Glucose modulation of ATP-sensitive K-currents in wild-type, homozygous and heterozygous glucokinase knock-out mice (1998) (44)
- Studies on the role of calcium ions in the stimulation by adrenaline of amylase release from rat parotid. (1974) (43)
- Calcitonin gene-related peptide and somatostatin inhibit insulin release from individual rat B cells (1988) (42)
- Cloning of the Promoters for the β-Cell ATP-Sensitive K-Channel Subunits Kir6.2 and SUR1 (1998) (42)
- A unique combination of plasma membrane Ca2+-ATPase isoforms is expressed in islets of Langerhans and pancreatic beta-cell lines. (1996) (42)
- Molecular structure of the glibenclamide binding site of the beta-cell K(ATP) channel. (2001) (42)
- Effects of Ca2+, calmodulin and cyclic AMP on the phosphorylation of endogenous proteins by homogenates of rt islets of langerhans. (1982) (41)
- The hypoglycaemic and insulinotropic activity of Tinospora crispa: studies with human and rat islets and HIT-T15 B cells (1989) (41)
- Effects of glucose on the cytosolic ration of reduced/oxidized nicotinamide-adenine dinucleotide phosphate in rat islets of Langerhans. (1979) (41)
- Cyclic AMP-dependent protein phosphorylation and insulin secretion in intact islets of Langerhans. (1984) (40)
- Regulation and specificity of glucose‐stimulated insulin gene expression in human islets of Langerhans (1987) (40)
- The beta-cell glibenclamide receptor is an ADP-binding protein. (1990) (40)
- Identification and characterization of Ca2+-phospholipid-dependent protein kinase in rat islets and hamster β-cells (1984) (38)
- Protein kinase activities in rat pancreatic islets of Langerhans. (1979) (38)
- The role of cytosolic free Ca2+ and protein kinase C in acetylcholine-induced insulin release in the clonal beta-cell line, HIT-T15. (1990) (38)
- Interactions of the Sulfonylurea Receptor 1 Subunit in the Molecular Assembly of β-Cell KATP Channels* (2000) (35)
- Expression of functionally active ATP‐sensitive K‐channels in insect cells using baculovirus (1998) (35)
- Expression of voltage‐gated K+ channels in insulin‐producing cells (1990) (34)
- Insulin secretory responses of a clonal cell line of simian virus 40-transformed B cells (1986) (33)
- Tracing and identification of uricase reaction intermediates : a direct 13C-NMR/isotope-labelling evidence (1992) (33)
- Glucose-6-phosphatase Activity of Mouse Pancreatic Islets (1968) (33)
- Morphological localisation of sulfonylurea receptor 1 in endocrine cells of human, mouse and rat pancreas (2007) (31)
- Stimulation of insulin release by vasopressin in the clonal beta-cell line, HIT-T15: the role of protein kinase C. (1992) (30)
- Cyclic nucleotide phosphodiesterase of rat pancreatic islets. Effects of Ca2+, calmodulin and trifluoperazine. (1981) (30)
- Effects of a phorbol ester and clomiphene on protein phosphorylation and insulin secretion in rat pancreatic islets. (1988) (29)
- The glucose sensor in HIT cells is the glucose transporter (1987) (29)
- Characterization of Ca2+/calmodulin-dependent protein kinase in rat pancreatic islets. (1993) (28)
- A truncated isoform of Ca2+/calmodulin‐dependent protein kinase II expressed in human islets of Langerhans may result from trans‐splicing (1997) (28)
- Differential expression of the inwardly-rectifying K-channel ROMK1 in rat brain. (1994) (27)
- Possible involvement of protein phosphorylation in the regulation of the sulphonylurea receptor of a pancreatic beta-cell line, HIT T15. (1991) (25)
- Potentiators of insulin secretion modulate Ca2+ sensitivity in rat pancreatic islets (1987) (24)
- The control of insulin release by sugars. (1976) (24)
- GLUCOSE METABOLISM AND INSULIN RELEASE BY PANCREATIC ISLETS (1968) (23)
- Effects of cholinergic agonists on diacylglycerol and intracellular calcium levels in pancreatic beta-cells. (1993) (23)
- Investigation of the molecular assembly of β‐cell KATP channels (2000) (22)
- Human calcium/calmodulin-dependent protein kinase II gamma gene (CAMK2G): cloning, genomic structure and detection of variants in subjects with Type II diabetes (2002) (21)
- Characterization of the solubilized glibenclamide receptor in a hamster pancreatic beta-cell line, HIT T15. (1991) (21)
- A potassium channel modulated by glucose metabolism in rat pancreatic beta-cells. (1986) (21)
- Glucose phosphorylation in mouse pancreatic islets. (1968) (21)
- Protein carboxymethylation in rat islets of Langerhans (1982) (20)
- ATP-sensitive K-channels in HIT T15 β-cells studied by patch-clamp methods, 86Rb efflux and glibenclamide binding (1989) (20)
- Human islets of Langerhans express multiple isoforms of calcium/calmodulin-dependent protein kinase II. (1997) (19)
- The beta-cell K(ATP) channel. (2000) (19)
- Expression of K channels in Xenopus laevis oocytes injected with poly(A+) mRNA from the insulin‐secreting β‐cell line, HIT T15 (1988) (19)
- Intracellular second messengers. (1997) (19)
- Protein phosphorylation and beta-cell function (1994) (19)
- The beta-cell sulfonylurea receptor. (1993) (18)
- Substrates for cyclic AMP-dependent protein kinase in islets of Langerhans. Studies with forskolin and catalytic subunit. (1985) (18)
- Antibodies to Synthetic Corticotrophin (1966) (18)
- Characterisation of endoplasmic reticulum and plasma membrane Ca(2+)-ATPases in pancreatic beta-cells and in islets of Langerhans. (1995) (18)
- Effect of secretagogues on cytosolic free Ca2+ and insulin release in the hamster clonal beta-cell line HIT-T15. (1988) (17)
- The effect of N-acylglucosamines on the biosynthesis and secretion of insulin in the rat. (1976) (17)
- The effects of glucose, N-acetylglucosamine, glyceraldehyde and other sugars on insulin release in vivo (1975) (16)
- Effects of dehydrouramil on protein phosphorylation and insulin secretion in rat islets of Langerhans. (1986) (16)
- Effects of phloretin and dextran-linked phloretin on pancreatic islet metabolism and insulin release. (1978) (16)
- Effects of growth hormone on insulin release in the rat (1980) (16)
- A novel pancreatic beta-cell isoform of calcium/calmodulin-dependent protein kinase II (beta 3 isoform) contains a proline-rich tandem repeat in the association domain. (1995) (15)
- 6 – Metabolic Controls of Insulin Secretion (1981) (15)
- Insulinotropic activity of Tinospora crispa extract: effect on ß‐cell Ca2+ handling (1998) (14)
- Effect of secretagogues on cytosolic free Ca2+ and insulin release at different extracellular Ca2+ concentrations in the hamster clonal β-cell line HIT-T15 (1989) (13)
- Phosphoenolpyruvate in rat pancreatic islets: A possible intracellular trigger of insulin release? (1977) (13)
- Protein phosphorylation in the regulation of insulin secretion and biosynthesis. (1990) (12)
- Effects of phosphoenolpyruvate, other glycolytic intermediates and methylxanthines on calcium uptake by a mitochondrial fraction from rat pancreatic islets (1978) (12)
- N‐acetylglucosamine and the substrate‐site hypothesis for the control of insulin biosynthesis and secretion (1978) (11)
- Identification and characterization of Ca2+-phospholipid-dependent protein kinase in rat islets and hamster beta-cells. (1984) (11)
- Characterization and solubilization of the sulphonylurea receptor in rat brain (1993) (11)
- Investigation of the molecular assembly of beta-cell K(ATP) channels. (2000) (10)
- Protein phosphorylation in the pancreatic B-cell (1984) (10)
- Determination of the molecular mass of the native β‐cell sulfonylurea receptor (1994) (10)
- [Metabolism and insulin secretion in isolated islets]. (1969) (9)
- Effect of Creatine on the Pancreatic ß -Cell (2007) (9)
- Structure‐activity relationships of alloxan‐like compounds derived from uric acid (1986) (8)
- Time course studies of glucose-induced changes in glucose-6-phosphate and fructose-1, 6-diphosphate content of mouse and rat pancreatic islets (1973) (8)
- Plasma uric acid and total antioxidant status in patients with diabetes mellitus. (1997) (7)
- GLUCOSE PHOSPHORYLATION AND GLUCOSE OXIDATION IN MOUSE PANCREATIC ISLETS AND THE RELEASE OF INSULIN (1970) (7)
- Carbohydrate metabolism in pancreatic islets and the release of insulin. (1969) (6)
- β-Cell recognition of stereoisomers of D-glucose (1979) (6)
- Control of insulin release by glucose. (1968) (5)
- Carbohydrate metabolism and the glucoreceptor mechanism. (1980) (5)
- Diabetogenic action of alloxan-like compounds: The effect of dehydrouramil hydrate hydrochloride on isolated islets of langerhans of the rat (1983) (5)
- Effect of creatine on the pancreatic beta-cell. (2007) (5)
- The beta-cell Ca2+/calmodulin-dependent protein kinase II (CaM kinase II) β3 isoform containing a proline-rich tandem repeat in the association domain can be found in the human genome (2001) (4)
- Effects of protein phosphorylation on the sulphonylurea receptor of the pancreatic beta-cell. (1997) (4)
- Structure-function relationships in the beta-cell K(ATP) channel. (2002) (4)
- Human islets of Langerhans express the δC isoform of calcium/calmodulin‐dependent protein kinase II (1999) (4)
- Effects of an enkephalin analogue (DAMME) on insulin release from cultured rat islets of langerhans (1981) (4)
- Detection of islet cell surface antibodies using cloned beta cells and comparison of their incidence with that of islet cell cytoplasmic antibodies. (1985) (4)
- THE USE OF GLUCOSE ANALOGUES IN THE ELUCIDATION OF THE MECHANISMS OF INSULIN RELEASE AND BIOSYNTHESIS (1978) (4)
- Effects of hypophysectomy and growth hormone on cultured islets of Langerhans of the rat (1982) (3)
- [Bioenergetics of islet function: islet glucose metabolism]. (1970) (3)
- Mechanisms in the control of insulin release by glucose and other substances. (1970) (3)
- Determination of the molecular mass of the native beta-cell sulfonylurea receptor. (1994) (3)
- Response to glucose of transcription factor binding to the rat insulin-1 gene promoter. (1994) (3)
- Diabetogenic action of alloxan-like compounds: cytotoxic effects of 5-hydroxy-pseudouric acid and dehydrouramil hydrate hydrochloride on rat pancreatic β cells (1984) (3)
- A novel simple method for the investigation of drug binding to the K(ATP) channel sulfonylurea receptor. (2002) (2)
- Trans-acting factor(s) confer glucose-responsive transcriptional regulation in the insulin gene. (1997) (2)
- Ca2+-activated K+ channels from an insulin-secreting cell line incorporated into planar lipid bilayers (1992) (2)
- Beta-cell recognition of stereoisomers of D-glucose. (1979) (2)
- The beta-cell ATP-sensitive K(+)-channel: effects of ADP at the sulphonylurea binding site. (1990) (2)
- Seventh Annual Meeting of the European Association for the Study Of Diabetes Southampton, England, September 15–17, 1971 Abstacts, Part 1 (1971) (1)
- Molecular Cloning of the cDNA Encoding β-Cell Calcium/Calmodulin-Dependent Protein Kinase II (1997) (1)
- INHIBITION OF LIPOLYTIC ACTIVITY OF SYNTHETIC β1–24 AND β1–39 CORTICOTROPHIN BY ANTI-ACTH ANTISERUM (1966) (1)
- Human insulin promoter driven reporter gene expression. (1993) (1)
- Molecular cloning of the cDNA encoding beta-cell calcium/calmodulin-dependent protein kinase II. (1997) (1)
- British Diabetic Association Abstracts (1968) (1)
- Functional effect of metabotropic glutamate and GABA receptors on Insulin Secretion (2000) (1)
- Annual Meeting of the Scandinavian Society for the Study of Diabetes (1972) (1)
- British Diabetic Association Abstracts Medical and Scientific Section, Autumn Meeting (1969) (0)
- Cyclic AMP, calmodulin and insulin secretion (1982) (0)
- Erratum (2004) (0)
- Glucose Metabolism inMousePancreatic Islets (1970) (0)
- Inter- and intramolecular interactions in the assembly of β-cell K-ATP channels (2000) (0)
- Ca2+-dependent phosphorylation of protein and phospholipid in homogenates of rat islets of Langerhans (1981) (0)
- Modulation of insulin release and islet protein phosphorylation by a phorbol ester tpa and clomiphene citrate cc (1987) (0)
- Ca(2+)-activated K+ channels from an insulin-secreting cell line incorporated into planar lipid bilayers. (1990) (0)
- Great Britain 547-Identification and characterization of Ca 2 +-phospholipid-dependent protein kinase in rat islets and hamster p-cells (2005) (0)
- Glucose Homeostasis (1968) (0)
- Eighth annual meeting of the European Association for the Study of Diabetes (1973) (0)
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