Steven Jacobs
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Biology
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Molecular Biology
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Biochemistry
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Biology
Steven Jacobs's Degrees
- PhD Biochemistry University of California, Berkeley
- Bachelors Chemistry University of California, Berkeley
Why Is Steven Jacobs Influential?
(Suggest an Edit or Addition)Steven Jacobs's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Monoclonal antibodies to receptors for insulin and somatomedin-C. (1983) (375)
- Blockade of the type I somatomedin receptor inhibits growth of human breast cancer cells in athymic mice. (1989) (361)
- Somatomedin-C stimulates the phosphorylation of the beta-subunit of its own receptor. (1983) (298)
- Insulin-like growth factor I receptor beta-subunit heterogeneity. Evidence for hybrid tetramers composed of insulin-like growth factor I and insulin receptor heterodimers. (1989) (240)
- Cellular receptor for 125I-labeled tumor necrosis factor: specific binding, affinity labeling, and relationship to sensitivity. (1985) (234)
- Phorbol esters stimulate the phosphorylation of receptors for insulin and somatomedin C. (1983) (217)
- The mobile receptor hypothesis and "cooperativity" of hormone binding. Application to insulin. (1976) (216)
- An antibody to the receptor for insulin-like growth factor I inhibits the growth of MCF-7 cells in tissue culture. (1987) (191)
- Structural similarities between human receptors for somatomedin C and insulin: analysis by affinity labeling. (1981) (176)
- Antibodies to purified insulin receptor have insulin-like activity. (1978) (170)
- Quantitative aspects of hormone-receptor interactions of high affinity. Effect of receptor concentration and measurement of dissociation constants of labeled and unlabeled hormones. (1975) (170)
- Insulin receptor: structure and function. (1981) (166)
- Association of phorbol ester-induced hyperphosphorylation and reversible regulation of transferrin membrane receptors in HL60 cells. (1984) (162)
- Insulin receptor: covalent labeling and identification of subunits. (1979) (161)
- Evidence from monoclonal antibody studies that insulin stimulates deoxyribonucleic acid synthesis through the type I somatomedin receptor. (1985) (155)
- Estimation of hormone receptor affinity by competitive displacement of labeled ligand: effect of concentration of receptor and of labeled ligand. (1975) (143)
- Purification and properties of insulin receptors from rat liver membranes. (1977) (141)
- Characterization of a neuronal subtype of insulin-like growth factor I receptor. (1987) (118)
- Monensin blocks the maturation of receptors for insulin and somatomedin C: identification of receptor precursors. (1983) (115)
- Purification and properties of the human placental insulin receptor. (1981) (106)
- Fluorescent labeling of hormone receptors in viable cells: preparation and properties of highly fluorescent derivatives of epidermal growth factor and insulin. (1978) (98)
- The subunit structure of rat liver insulin receptor. Antibodies directed against the insulin-binding subunit. (1980) (90)
- Mechanism of phorbol diester-induced regulation of surface transferrin receptor involves the action of activated protein kinase C and an intact cytoskeleton. (1985) (83)
- Modulation of binding and bioactivity of insulin by anti-insulin antibody: relation to possible role of receptor self-aggregation in hormone action. (1979) (82)
- Phosphorylation of receptors for insulin and insulin-like growth factor I. Effects of hormones and phorbol esters. (1986) (81)
- Interaction of the Monoclonal Antibodies αlR-1 and αIR-3 with Insulin and Somatomedin-C Receptors (1986) (71)
- Association of phosphorylated insulin-like growth factor-I receptor with the SH2 domains of phosphatidylinositol 3-kinase p85. (1992) (67)
- Putative mediators of insulin action: regulation of pyruvate dehydrogenase and adenylate cyclase activities. (1982) (65)
- Insulin stimulates the release from liver plasma membranes of a chemical modulator of pyruvate dehydrogenase. (1981) (63)
- Monoclonal and anti-idiotypic antibodies as probes for receptor structure and function. (1984) (50)
- Putative mediators of insulin action regulate hepatic acetyl CoA carboxylase activity. (1983) (50)
- Purification of insulin-like growth factor I receptor from human placental membranes. (1986) (44)
- Effects of inhibitors of N-linked oligosaccharide processing on the biosynthesis and function of insulin and insulin-like growth factor-I receptors. (1988) (43)
- Digestion of insulin receptors with proteolytic and glycosidic enzymes-effects on purified and membrane-associated receptor subunits. (1980) (42)
- Monoclonal antibody αIR‐3 inhibits non‐small cell lung cancer growth in vitro and in vivo (1996) (42)
- Activation of adenylate cyclase by phosphoramidate and phosphonate analogs of GTP: possible role of covalent enzyme-substrate intermediates in the mechanism of hormonal activation. (1975) (41)
- Partial down‐regulation of protein kinase C reverses the growth inhibitory effect of phorbol esters on HepG2 cells (1990) (40)
- A monoclonal antibody to human insulin receptor. (1982) (39)
- Disulfide reduction converts the insulin receptor of human placenta to a low affinity form. (1980) (39)
- Insulin/IGF‐I receptor hybrids: A mechanism for increasing receptor diversity (1992) (38)
- Complete glycosylation of the insulin and insulin-like growth factor I receptors is not necessary for their biosynthesis and function. Use of swainsonine as an inhibitor in IM-9 cells. (1986) (38)
- The mobile receptor hypothesis for cell membrane receptor action (1977) (24)
- Cell receptors in disease. (1977) (21)
- Membrane receptors : methods for purification and characterization (1981) (20)
- The effect of protein kinase-C inhibition on insulin receptor phosphorylation. (1990) (17)
- Monoclonal antibody alpha IR-3 inhibits non-small cell lung cancer growth in vitro and in vivo. (1996) (13)
- Interaction of the monoclonal antibodies alpha IR-1 and alpha IR-3 with insulin and somatomedin-C receptors. (1986) (11)
- Visualization of the Insulin Receptor by Immunoblotting (1984) (10)
- Insulin receptor antibodies. (1981) (10)
- Binding of (3H)guanylylimidodiphosphate to membranes: lack of correlation with adenylate cyclase activation. (1976) (8)
- Kinetics of irreversible activation of adenylate cyclase of fat cell membranes by phosphonium and phosphoramidate analogs of gtp1. (1976) (7)
- Insulin receptors. (1983) (7)
- Analysis of the insulin receptor by anti-receptor antibodies and flow cytometry. (1984) (6)
- [35] Purification of insulin receptor from human placenta (1985) (6)
- Purification of insulin receptor from human placenta. (1985) (4)
- Affinity Chromatography for Membrane Receptor Purification (1981) (4)
- Insulin receptors and insulin receptor antibodies: structure-function relationships. (1982) (3)
- Immunochemical Characterization of Receptors for Insulin and Insulinlike Growth Factor-I (1985) (3)
- Problems in Studying Hormone Receptor Binding (1979) (3)
- Insulin-like Growth Factor I Receptors (1990) (3)
- Activation of adenylate cyclase by Guanosine 5′ α, β methylene triphosphate (1977) (2)
- Hybrid receptors. (1991) (2)
- Irreversible stimulation of adenylate cyclase activity of fat cell membranes by phosphoramidate and phosphonate analogs of GTP (2005) (1)
- IGF I Receptor Phosphorylation (1989) (0)
- Biochemical problems in the study of the insulin receptor. (1977) (0)
- Phorbol esters stimulate thephosphorylation ofreceptors for insulin andsomatomedin C (insulin-like growth factor I/phorbol tetradecanoate acetate/phorbol dibutyrate/protein (1983) (0)
- Structure-function relations of the thyrotropin receptor - discussion (1982) (0)
- Insulin Receptor Structure and Antibodies (1982) (0)
- 1340 – PROBLEMS IN STUDYING HORMONE RECEPTOR BINDING (1978) (0)
- Monoclonal Antibodies as Probes for Insulin and Insulin-like Growth Factor-I Receptors (1984) (0)
- Monensin blocks the maturation of somatomedin C: Idetification. of -.r (receptor biosynthesis/receptor antibodies/insulin-like growth factors (2016) (0)
- Structural Similarity of Human and Bovine Somatomedin Receptors and Human Insulin Receptor: Analysis by Affinity Labeling (1981) (0)
- Activation of adenylate cyclase by guanosine 5' alpha, beta methylene triphosphate. (1977) (0)
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