Shumpei Sakakibara

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Shumpei Sakakibara

Medical

#2674

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#3105

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Pharmacology

#291

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#340

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Shumpei Sakakibara's Degrees

PhD Pharmaceutical Sciences University of Tokyo

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Shumpei Sakakibara's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Primary structure, synthesis, and biological activity of rat endothelin, an endothelium-derived vasoconstrictor peptide. (1988) (524)
Cellular mechanism of action by a novel vasoconstrictor endothelin in cultured rat vascular smooth muscle cells. (1988) (378)
Use of anhydrous hydrogen fluoride in peptide synthesis. I. Behavior of various protective groups in anhydrous hydrogen fluoride. (1967) (343)
New Fluorogenic Substrates for α-Thrombin, Factor Xa, Kallikreins, and Urokinase (1977) (335)
New chromogenic substrates for X-prolyl dipeptidyl-aminopeptidase. (1976) (316)
Specific receptors for adrenomedullin in cultured rat vascular smooth muscle cells (1994) (299)
Immunoreactive adrenomedullin in human plasma (1994) (296)
Synthesis of (Pro-Hyp-Gly) n of defined molecular weights. Evidence for the stabilization of collagen triple helix by hydroxypyroline. (1973) (247)
Highly sensitive peptide-4-methylcoumaryl-7-amide substrates for blood-clotting proteases and trypsin. (1988) (233)
Structure-activity relationship of adrenomedullin, a novel vasodilatory peptide, in cultured rat vascular smooth muscle cells. (1994) (226)
Chromogenic substrates for horseshoe crab clotting enzyme. Its application for the assay of bacterial endotoxins. (1978) (209)
The complete amino acid sequence of ?-neo-endorphin (1981) (132)
Chemotactic Activity of Collagen‐Like Polypeptides for Human Peripheral Blood Neutrophils (1986) (125)
Successive cleavage of N-terminal Arg1--Pro2 and Lys3-Pro4 from substance P but no release of Arg1-Pro2 from bradykinin, by X-Pro dipeptidyl-aminopeptidase. (1978) (124)
A new method for releasing oxytocin from fully-protected nona-peptides using anhydrous hydrogen fluoride. (1965) (122)
Synthetic substrates for vertebrate collagenase. (1977) (121)
Synthesis of Poly-(L-prolyl-L-prolylglycyl) of Defined Molecular Weights (1968) (119)
Dimerization of Midkine by Tissue Transglutaminase and Its Functional Implication* (1997) (119)
Changes in Prolyl Endopeptidase During Maturation of Rat Brain and Hydrolysis of Substance P by the Purified Enzyme (1980) (117)
Enzyme-assisted semisynthesis of human insulin (1979) (115)
Crystal structure of an elastase-specific inhibitor elafin complexed with porcine pancreatic elastase determined at 1.9 A resolution. (1996) (107)
Chemical synthesis of proteins. (1995) (105)
Binding of ω-conotoxin to receptor sites associated with the voltage-sensitive calcium channel (1986) (99)
The cystine‐stabilized α‐helix: A common structural motif of ion‐channel blocking neurotoxic peptides (1991) (96)
Effects of the stereo-configuration of the hydroxyl group in 4-hydroxyproline on the triple-helical structures formed by homogenous peptides resembling collagen. (1976) (95)
Fluorescence assay of x-prolyl dipeptidyl-aminopeptidase activity with a new fluorogenic substrate. (1978) (92)
A SYNTHESIS OF OXYTOCIN. (1965) (89)
Synthesis and physical properties of (hydroxyproline-proline-glycine)10: hydroxyproline in the X-position decreases the melting temperature of the collagen triple helix. (1982) (88)
Chemical synthesis of the precursor molecule of the Aequorea green fluorescent protein, subsequent folding, and development of fluorescence. (1998) (88)
New fluorogenic peptide substrates for plasmin. (1980) (86)
β-Neo-endorphin, a new hypothalamic “big” Leu-enkephalin of porcine origin: Its purification and the complete amino acid sequence (1981) (83)
Strategy for the synthesis of large peptides: An application to the total synthesis of human parathyroid hormone [hPTH(1–84)] (1981) (76)
Synthesis and disulfide structure determination of porcine endothelin: an endothelium-derived vasoconstricting peptide. (2009) (75)
A new and highly sensitive fluorescence assay for collagenase-like peptidase activity. (1979) (74)
Amino acid sequence and relative biological activity of eel atrial natriuretic peptide. (1989) (73)
Solution conformation of endothelin determined by means of 1H-NMR spectroscopy and distance geometry calculations. (1991) (69)
Carboxyl-terminal parathyroid hormone fragments stimulate osteoclast-like cell formation and osteoclastic activity. (1994) (67)
Enzyme-linked immunoassay for midkine, and its application to evaluation of midkine levels in developing mouse brain and sera from patients with hepatocellular carcinomas. (1996) (67)
Studies on protocollagen lysine hydroxylase. Hydroxylation of synthetic peptides and the stoichiometric decarboxylation of -ketoglutarate. (1972) (66)
A novel natriuretic peptide isolated from eel cardiac ventricles (1991) (66)
Synthesis of large peptides in solution (1995) (65)
Studies on the Synthesis of Histidine Peptides. I. Nim-Tosylhistidine Derivatives as Starting Materials (1974) (63)
Synthesis of a Key Fluorogenic Amide, L-Arginine-4-methylcoumaryl-7-amide (L-Arg-MCA) and Its Derivatives. Fluorescence Assays for Trypsin and Papain (1977) (63)
Powerful solvent systems useful for synthesis of sparingly-soluble peptides in solution. (2009) (63)
Primary and secondary structure of conotoxin GI, a neurotoxic tridecapeptide from a marine snail (1982) (62)
Steric structure of L‐proline oligopeptides. II. Far‐ultraviolet absorption spectra and optical rotations of L‐proline oligopeptides (1968) (62)
Localization of heparin-binding, neurite outgrowth and antigenic regions in midkine molecule. (1994) (60)
An Approach to the Specific Cleavage of Peptide Bonds. I. The Acyl Migration in Dipeptides Containing Hydroxyamino Acids in Anhydrous Hydrogen Fluoride (1962) (59)
Amino acid sequence and relative biological activity of a natriuretic peptide isolated from eel brain. (1990) (58)
The trifluoroacetate method of peptide synthesis. I. The synthesis and use of trifluoroacetate reagents. (1965) (57)
An x-ray study of the synthetic polypeptide (Pro-Pro-Gly) 10 . (1972) (57)
Midkine is a heat and acid stable polypeptide capable of enhancing plasminogen activator activity and neurite outgrowth extension. (1995) (56)
Synthesis of Endothelin‐1 Analogues, Endothelin‐3, and Sarafotoxin S6b: Structure‐Activity Relationships (1989) (56)
Single crystals of (Pro-Pro-Gly) 10, a synthetic polypeptide model of collagen. (1972) (55)
Identification of plasma inactive renin as prorenin with a site-directed antibody. (1985) (55)
Effects of synthetic ω-conotoxin on synaptic transmission (1987) (55)
Hydrolysis of synthetic peptides by collagenase. (1960) (54)
Receptor binding activity and cytosolic free calcium response by synthetic endothelin analogs in cultured rat vascular smooth muscle cells. (1989) (51)
A New Method for the Protection of the Sulfhydryl Group during Peptide Synthesis (1964) (49)
Solution synthesis of charybdotoxin (ChTX), a K+ channel blocker. (1990) (49)
Chemical structures of angiotensins formed by incubating plasma with the kidney and the corpuscles of Stannius in the chum salmon, Oncorhynchus keta. (1983) (47)
Hydroxylation of (X-Pro-Gly)n by protocollagen proline hydroxylase. Effect of chain length, helical conformation and amino acid sequence in the substrate. (1972) (46)
A membrane-bound, calcium-dependent protease in yeast alpha-cell cleaving on the carboxyl side of paired basic residues. (1987) (43)
Steric structure of L‐proline oligopeptides. I. Infrared absorption spectra of the oligopeptides and poly‐L‐proline (1968) (42)
Solution conformation of conotoxin GI determined by 1H nuclear magnetic resonance spectroscopy and distance geometry calculations. (1989) (41)
The Modification of Tryptophyl Residues during the Acidolytic Cleavage of Boc-groups. I. Studies with Boc-Tryptophan (1980) (41)
Synthesis of the mating factor of Saccharomyces cerevisiae and its truncated peptides : the structure-activity relationship. (1977) (40)
Serum glycylproline p-nitroanilidase activity in rheumatoid arthritis and systemic lupus erythematosus. (1978) (40)
Synthetic ω-conotoxin: a potent calcium channel blocking neurotoxin (1987) (40)
A new fluorogenic peptide substrate for vitamin K-dependent blood coagulation factor, bovine protein C. (1981) (39)
The 69-84 amino acid region of the parathyroid hormone molecule is essential for the interaction of the hormone with the binding sites with carboxyl-terminal specificity. (1996) (38)
A New Reagent for the p-Nitrophenylation of Carboxylic Acids (1964) (37)
Conformations of yeast α‐mating factor and analog peptides as bound to phospholipid bilayer (1987) (37)
Receptor binding and vasoconstrictor activity of big endothelin. (1990) (37)
Synthetic peptides derived from midkine enhance plasminogen activator activity in bovine aortic endothelial cells. (1995) (37)
Fluorogenic Peptide Substrates for Proteases in Blood Coagulation, Kallikrein-Kinin and Fibrinolysis Systems: Substrate for Plasmin and Factor XIa (1979) (37)
Solution Structure of ω-Conotoxin MVIIC Determinined by NMR (1995) (37)
Synthesis and structure-activity relationships of elafin, an elastase-specific inhibitor. (1992) (36)
1,6-Aminosuberic acid analogs of lysine- and arginine-vasopressin and -vasotocin. Synthesis and biological properties. (1972) (36)
A new fluorogenic substrate method for the estimation of kallikrein in urine. (1980) (36)
New fluorogenic substrates for renin. (1981) (35)
Synthesis and secondary-structure determination of omega-conotoxin GVIA: a 27-peptide with three intramolecular disulfide bonds. (1986) (35)
Chemical synthesis of proteins in solution. (1999) (34)
Serum glycylproline p-nitroanilidase activity in blood cancers. (1977) (34)
A model for the triple-helical structure of (Pro-Hyp-Gly)10 involving a cis peptide bond and inter-chain hydrogen-bonding to the hydroxyl group of hydroxyproline. (1973) (32)
Individual and combined effects of intact PTH, amino-terminal, and a series of truncated carboxyl-terminal PTH fragments on alkaline phosphatase activity in dexamethasone-treated rat osteoblastic osteosarcoma cells, ROS 17/2.8. (1993) (32)
Synthesis and use of N-im-tosyl-L-histidine. (1969) (31)
Amino acid substitution of mating factor of Saccharomyces cerevisiae structure-activity relationship. (1979) (31)
FS2. a mamba venom toxin, is a specific blocker of the L-type calcium channels. (1994) (31)
Physiological activities of peptides are correlated with the conformations of membrane‐bound molecules (1983) (31)
t-Amyloxycarbonyl as a new protecting group in peptide synthesis. I. The synthesis and properties of N-t-amyloxy- carbonylamino acids and related compounds. (1965) (30)
t-Amyloxycarbonyl as a New Protecting Group in Peptide Synthesis. V. Direct Synthesis of t-Amyloxycarbonyl- and t-Butyloxycarbonyl-amino Acids Using the Respective t-Alkyl Chloroformates (1969) (30)
Vasopressor activities of N-terminal fragments of adrenomedullin in anesthetized rat. (1996) (30)
Calciseptine binding to a 1,4-dihydropyridine recognition site of the L-type calcium channel of rat synaptosomal membranes. (1993) (30)
The synthetic polytripeptides (Pro-Pro-Gly)10 and (Pro-Pro-Gly)20 form micro-crystalline structures similar to segmental structures formed by collagen. (1971) (29)
A sensitive and specific assay for dipeptidyl-aminopeptidase II in serum and tissues by liquid chromatography-fluorometry. (1985) (29)
Oxidative folding of ω‐conotoxin MVIIC: Effects of temperature and salt (1996) (28)
Synthesis of Poly-(L-prolyl-L-leucyl-glycyl). An Attempted Synthesis of Model Collagen (1958) (28)
Structure-activity relationships of α-human atrial natriuretic peptide (1988) (28)
Kinetic studies on surface-mediated activation of bovine factor XII and prekallikrein. Effects of kaolin and high-Mr kininogen on the activation reactions. (1985) (28)
Excretion of X-prolyl dipeptidyl-aminopeptidase in human urine as determined with a new fluorogenic substrate. (1978) (27)
A C type natriuretic peptide is a vasodilator in vivo and in vitro in the common dogfish. (1992) (27)
Determination of the optical purity of amino acids by high-performance liquid chromatography (1981) (27)
Nuclear-magnetic-resonance studies on the conformation of membrane-bound α-mating factor (1986) (26)
Solution synthesis of human midkine, a novel heparin-binding neurotrophic factor consisting of 121 amino acid residues with five disulphide bonds. (1996) (26)
Use of anhydrous hydrogen fluoride in peptide synthesis. II. Procedures for the syntheses of simple peptides. (1968) (26)
Synthesis and biological properties of antiparallel and parallel dimers of α-human atrial natriuretic peptide (1986) (25)
Synthesis of human osteocalcins: gamma-carboxyglutamic acid at position 17 is essential for a calcium-dependent conformational transition. (1994) (25)
Substrate specificity of vertebrate collagenase (1976) (25)
New Calcitonin Isolated from the Ray, Dasyatis akajei. (1991) (24)
Smooth muscle relaxing and hypotensive activities of synthetic calciseptine and the homologous snake venom peptide FS2. (1995) (24)
Crystalline deamino-dicarba-oxytocin. Preparation and some pharmacological properties. (1970) (24)
Hydroxylation of (Pro-Pro-Gly)5 and (Pro-Pro-Gly)10 by prolyl hydroxylase. Evidence for an asymmetric active site in the enzyme. (1977) (24)
Studies on the Synthesis of Peptides Containing Glutamine as the C-Terminal. I. Protection of Amide-nitrogen with Xanthyl Group during Peptide Synthesis (1962) (23)
Synthesis of ω-Agatoxin IVA and Its Related Peptides (1993) (23)
Nin-cyclohexyloxycarbonyl group as a new protecting group for tryptophan (1996) (22)
Goldfish calcitonin: purification, characterization, and hypocalcemic potency. (1993) (22)
Synthesis and NMR structure of p41icf, a potent inhibitor of human cathepsin L. (2003) (22)
The biological activity of endothelin-1 analogues in three different assay systems. (1991) (22)
Structure-activity relations of conotoxins at the neuromuscular junction. (1985) (22)
A neurohypophyseal hormone analog with selective oxytocin-like activities and resistance to enzymatic inactivation: an approach to the design of peptide drugs. (1974) (22)
Solution synthesis of human midkine, a novel heparin‐binding neurotrophic factor consisting of 121 amino acid residues with five disulphide bonds (1996) (22)
Asymmetry in the hydroxylation of (Pro-Pro-Gly) 5 by protocollagen proline hydroxylase. (1971) (22)
Side reaction in peptide synthesis: Modification of tryptophan during treatment with mercury(II) acetate/2-mercaptoethanol in aqueous acetic acid (1994) (21)
The trifluoroacetate method of peptide synthesis. II. An improved synthesis of bradykinin. (1966) (21)
Structural basis for the biological activity of dendrotoxin-I, a potent potassium channel blocker. (2000) (20)
Solution structure of α-conotoxin MI determined by -NMR spectroscopy and molecular dynamics simulation with the explicit solvent water (1997) (20)
Calcitonin of the stingray: comparison of the hypocalcemic activity with other calcitonins. (1992) (20)
Study of the synthesis of histidine peptides. II. Use of Nim-tosylhistidine derivatives in conventional solution synthesis of peptides. (1976) (20)
A New Protective Group Suitable for Masking Specific Amino Groups during Peptide Synthesis (1970) (20)
Synthesis of an O-palmitoylated 44-residue peptide amide (PLTX II) blocking presynaptic calcium channels in Drosophila. (1995) (19)
Interaction of synthetic sarafotoxin with rat vascular endothelin receptors. (1989) (19)
Specific pressor activity and stability of synthetic angiotensins. (1977) (19)
Effects of Endothelin‐1 and Endothelin‐3 on Blood Pressure in Conscious Hypertensive Rats (1989) (18)
A proposal for using mild bases in the preparation of optically pure peptides. (1967) (18)
Comparative biochemistry of renins and angiotensins in the vertebrates. (1978) (17)
Synthesis of an Analogue of Desamino-lysine-vasopressin Containing No Disulfide Bond (1968) (17)
t-Amyloxycarbonyl as a new protecting group in peptide synthesis. II. Synthesis of a hexapeptide amide related to eledoisin by the t-amyloxycarbonyl method. (1966) (16)
Crystallization of a complex between an elastase-specific inhibitor elafin and porcine pancreatic elastase. (1993) (16)
Nuclear-magnetic-resonance studies on the conformations of tridecapeptide alpha-mating factor from yeast Saccharomyces cerevisiae and analog peptides in aqueous solution. Conformation-activity relationship. (1984) (16)
Total synthesis of human parathyroid hormone (1–84) (1982) (16)
Comparison of reversed-phase and cation-exchange high-performance liquid chromatography for separating closely related peptides: separation of Asp76-human parathyroid hormone (1-84) from Asn76-human parathyroid hormone (1-84). (1985) (16)
Solution synthesis of calciseptine, an L-type specific calcium channel blocker. (1992) (15)
Solution synthesis of [ASN76]-human parathyroid hormone (1-84). (1983) (15)
New angiotensin I isolated from a reptile, Alligator mississippiensis. (1993) (15)
Changes in serum dipeptidyl-aminopeptidase IV (glycylprolyl dipeptidyl-aminopeptidase) activity of patients with gastric carcinoma after surgical excision and the enzyme activity in the carcinoma tissue. (1981) (15)
Conformational study of endothelins and sarafotoxins with the cystine‐stabilized helical motif by means of CD spectra (1992) (14)
t-Amyloxycarbonyl as a new protecting group in peptide synthesis. IV. Synthesis and use of t-amyl azidoformate. (1967) (14)
The Solid-phase Synthesis of Ile5-Angiotensin II to Demonstrate the Use of Nim-Tosyl-histidine (1970) (13)
Studies on substrate specificity of X-prolyl dipeptidyl-aminopeptidase using new chromogenic substrates, X-Y-p-nitroanilides (1978) (13)
Use of anhydrous hydrogen fluoride in peptide synthesis. 3. Synthesis of Bradykinin. (1968) (13)
The N, O peptidyl shift in anhydrous hydrogen fluoride. (1962) (12)
The complete amino acid sequence of alpha-neo-endorphin. (1981) (12)
Serum glyccylproline p-nitroanilidase activity in human hypertension. (1977) (12)
Studies on Dehydroalanine Derivatives. I. Synthesis of N-Carboxy-dehydroalanine Anhydride (1959) (12)
Synthesis of DL-α-Aminosuberic Acid and Its Optical Resolution (1968) (11)
Synthesis and Use of L-Histidine Benzylester (1958) (11)
Biological activities of synthetic human parathyroid hormone (PTH) 1-84 relative to natural bovine 1-84 PTH in two different in vivo bioassay systems. (1985) (11)
Total synthesis of porcine cholecystokinin-33 (CCK-33) (1987) (10)
Synthesis of porcine C5a anaphylatoxin by the solution procedure and confirmation of the reported structure. (1988) (10)
Synthesis of Polycysteine (1956) (10)
A synthetic analogue for the active site of plant‐type ferredoxin: Two different coordination isomers by a four‐Cys‐containing [20]‐peptide (1992) (10)
Strategy for the chemical synthesis of large peptides; synthesis of angiogenin as an example. (1990) (10)
The Presence of Substance P Carboxy-Terminal Heptapeptide in Pig Brain Stem (1980) (10)
Synthesis and disulfide structure determination of agelenin: identification of the carboxy-terminus as an amide form. (1992) (10)
Unexpected racemization of proline or hydroxy-proline phenacyl ester during coupling reactions with Boc-amino acids. (2009) (9)
Comparison of X-prolyl dipeptidyl-aminopeptidase activity in human cerebrospinal fluid with that in serum (1979) (9)
Synthesis of cytochrome C type core from protoporphyrinogen. (1964) (8)
Solution structure of alpha-conotoxin MI determined by 1H-NMR spectroscopy and molecular dynamics simulation with the explicit solvent water. (1997) (8)
t-Amyloxycarbonyl as a new protecting group in peptide synthesis. 3. An unexpected side-reaction during the synthesis of t-amyloxycarbonylamino acids. (1967) (8)
Novel peptides with orally active and long-lasting antihypertensive activity. (1984) (8)
Suppression of a side reaction associated with N(im)-benzyloxymethyl group during synthesis of peptides containing cysteinyl residue at the N-terminus. (1991) (8)
Amino acid sequence of sardine calcitonin and its hypocalcemic activity in rats. (1994) (8)
A NOVEL ENZYME IN RAT BRAIN CONVERTING β‐ENDORPHIN INTO METHIONINE ENKEPHALIN: AFFINITY CHROMATOGRAPHY AND SPECIFICITY (1979) (8)
Aspartate racemization in synthetic peptides. Part 2. Tendency to racemization of aminosuccinyl residue (1991) (8)
Binding of synthetic β‐human atrial natriuretic peptide to cultured rat vascular smooth muscle cells (1987) (8)
Oxidative folding of omega-conotoxin MVIIC: effects of temperature and salt. (1996) (8)
Solution synthesis of mu-conotoxin GIIIB: optimization of the oxidative folding reaction. (1993) (8)
Oxytocin Analogues Containing No Disulfide Bond. I. Synthesis of the Lactam of L-Tyrosyl-L-isoleucyl-L-glutaminyl-L-asparaginyl-L-α-aminosuberyl-L-prolyl-L-leucylglycine Amide (1969) (7)
Chemical synthesis of dendrotoxin-I: revision of the reported structure. (1996) (7)
Biological properties of synthetic human parathyroid hormone: effect of deamidation at position 76 on agonist and antagonist activity. (1991) (7)
AGELENIN, A SPIDER NEUROTOXIN: DETERMINATION OF THE C-TERMINUS AS AMIDE FORM, AND INVESTIGATION OF THE DISULFIDE BOND ARRANGEMENT (1991) (7)
Solution synthesis of Na+,K(+)-ATPase inhibitor-1 (SPAI-1). (1992) (7)
Studies on Dehydroalanine Derivatives. II. Synthesis of Polydehydroalanine (1960) (7)
Generation of two isomers with the same disulfide connectivity during disulfide bond formation of human uroguanylin (1996) (6)
Changes of X-prolyl dipeptidyl-aminopeptidase activity in developing rat brain (1979) (6)
Application of the two‐dimensional nmr techniques on a des(Ala,Gly)‐somatostatin analog (1981) (6)
Cleavage of des-Arg9-bradykinin by angiotensin I-converting enzyme from pig kidney cortex (1985) (6)
Molecular mechanism of action by atrial natriuretic peptide in rat vascular smooth muscle cells. (1988) (6)
Synthetic parathyroid hormone fragments shortened at the amino terminus stimulate glucose‐6‐phosphate dehydrogenase activity in the distal renal tubule (1987) (6)
Hydrolysis of lignin with dioxane-water, 18: Isolation of a new lignol from hardwood lignin (1979) (6)
SYNTHESIS OF A REVERSIBLY CONTRACTILE AMPHOTERIC POLYPEPTIDE (1953) (6)
Structure of potentiator A, one of the five bradykinin potentiating peptides from the venom ofAgkistrodon halys blomhoffii (1973) (6)
High Performance Liquid Chromatography of Bradykinin and Its Application to the Degradation Study of Bradykinin in Plasma (生体成分の高速液体クロマトグラフィ (1984) (5)
Binding of omega-conotoxin to receptor sites associated with the voltage-sensitive calcium channel. (1986) (5)
The Synthesis of a Series of N-t-Amyloxycarbonyl-oligo-L-proline (1970) (5)
Synthesis of Bz-Phe(p-No2)-Val-Arg-pNA-and its specificity to thrombin-like enzymes: similarity of a commercial product S-2160 to the nitrated compound. (1980) (5)
Synthetic Amphoteric Polypeptide. I. Syntheses and Some Properties of Linear Amphoteric Polypeptides (1956) (5)
Solution structure of omega-conotoxin MVIIC determined by NMR. (1995) (5)
Effects of synthetic omega-conotoxin on synaptic transmission. (1987) (5)
Polycondensation of Tripeptide with Bis-o-phenylene Pyrophosphite (1962) (5)
Synthetic Amphoteric Polypeptide. II. Synthesis and Some Properties of a Reversibly Contractile Amphoteric Polypeptide (1956) (5)
Syntheses of Peptides Containing Proline. I. Syntheses of Glycyl-L-prolyl-L-leucyl-glycyl-L-proline and its Related Compounds (1960) (5)
Cardiovascular effects of two disulfide analogues of sarafotoxin S6b. (1990) (5)
Immunological properties of synthetic human parathyroid hormone: effect of deamidation at position 76. (1987) (4)
On the Photochemical Decomposition of 2, 4-Dinitrophenyl Peptides (1959) (4)
Beta-neo-endorphin, a new hypothalamic "big" Leu-enkephalin of porcine origin: its purification and the complete amino acid sequence. (1981) (4)
Potentiating effects of bradykinin-related substances on bradykinin-induced contraction of guinea pig ileum and hypotension in rats. (1981) (4)
Solution structure of charybdotoxin determined by NMR and distance geometry calculations (1991) (4)
Synthesis and disulfide structure determination of ω-agatoxin IVA (1994) (4)
Specific pressor activity of angiotensins I and II. (1973) (4)
Binding of the carboxyl-terminal fragments of human parathyroid hormone to rat osteoblastic cells ROS 17/2.8 (1994) (3)
Collagenase-like peptidase activity in serum from patients with rheumatoid arthritis (1985) (3)
Conformational studies of oxytocin analogues with different ring sizes. I. Circular dichroism. (1979) (3)
Solution synthesis and disulfide structure determination of rat cytokine-induced neutrophil chemoattractant, a member of the interleukin-8 family (1992) (3)
Oxytocin Analogues Containing No Disulfide Bond. III. The Synthesis of Three Analogues of 1,6-Aminosuberic Acid-Oxytocin (1974) (3)
Use of 1-Hydroxybenztriazole in Peptide Synthesis (1974) (3)
Action of fragments of human parathyroid hormone on blood pressure in rats. (1981) (3)
Studies on Dehydroalanine Derivatives. V. Radical Polymerization of N -Carboxy-dehydroalanine Anhydride and of N -Phthaloyl-dehydroalanine. Synthesis of a New Amphoteric Polymer (1961) (3)
Improvement in the oxidative folding of endothelin-1 by a Lys-Arg extension at the amino terminus: Implication of a salt bridge between Arg-1 and Asp8 (2004) (3)
Reduction of serum X-prolyl dipeptidyl-aminopeptidase activity in tumour-bearing mice and reversal of reduced enzyme activity by lentinan, an anti-tumour polysaccharide (1979) (3)
A new assay of X-prolyl dipeptidyl-aminopeptidase activity in human serum with glycylproline p-phenylazoanilide as substrate (1979) (3)
Effect of an amide group in place of the disulfide bridge in deamino-oxytocin. (1972) (3)
Studies on Dehydroalanine Derivatives. IV. Synthesis of N-PhthaloylDehydroalanine by Thermal Decomposition of Cysteine and Serine in the Presence of Phthalic Anhydride (1961) (2)
Nuclear-magnetic-resonance studies on the conformation of membrane-bound alpha-mating factor. Transferred nuclear Overhauser effect analysis. (1986) (2)
Synthesis and disulfide structure determination of conotoxin GS, a γ-carboxyglutamic acid-containing neurotoxic peptide (1995) (2)
Conformations of yeast alpha-mating factor and analog peptides as bound to phospholipid bilayer. Correlation of membrane-bound conformation with physiological activity. (1987) (2)
Synthetic omega-conotoxin: a potent calcium channel blocking neurotoxin. (1987) (2)
[Physiological and pathological chemistry of X-prolyl dipeptidyl-aminopeptidase (dipeptidyl-aminopeptidase IV)]. (1980) (2)
Synthesis of omega-agatoxin IVA and its related peptides. (1993) (2)
Total synthesis of human pleiotrophin, a 136-residue heparin-binding neurotrophic factor having five disulfide bonds (1999) (2)
Improvement in the oxidative folding of endothelin-1 by a lys-Arg extension at the amino terminus: Implication of a salt bridge between Arg−1 and Asp8 (1997) (2)
Immunoreactive AM in human plasma (1994) (2)
Synthesis of Des-Pro 2 -Bradykinin and Its Behavior in Chromatography (1981) (1)
Total synthesis of porcine and human cholecystokinin-33 (CCK-33) by the classical solution procedure (1988) (1)
Chemical Synthesis of Proteins in Solution (2010) (1)
Synthesis and biological properties of antiparallel and parallel dimers of alpha-human atrial natriuretic peptide. (1986) (1)
Substrate specificity of vetebrate collagenase. (1976) (1)
Solution syntheses of α-conotoxin SI and its biological activity (1993) (1)
Serum collagenase-like peptidase activity in rheumatoid arthritis and systemic lupus erythematosus. (1985) (1)
TOTAL SYNTHESIS OF HUMAN PARATHYROID HORMONE (1-84) (1982) (1)
The [53–63] amino acid portion of the parathyroid hormone molecule is essential for the stimulatory effect of carboxyl-terminal PTH fragments on alkaline phosphatase activity in dexamethasone-treated rat osteoblastic osteosarcoma cells, ROS 17/2.8 (1994) (1)
Anhydrous Hydrogen Fluoride as Solvent. (1967) (1)
Synthesis of γ-carboxyglutamic acid-containing peptides by Boc strategy using HF for final deprotection (1993) (1)
Studies on Dehydroalanine Derivatives. III. Formation of Amino Acids from Poly-dehydroalanine (1961) (1)
Solution structure of charybdotoxin-iberiotoxin hybrid analog (1995) (0)
Syntheses of iberiotoxin and its related peptides (1993) (0)
[Inhibition of angioten converting enzyme by phosphryl derivatives in rats (author's transl)]. (1981) (0)
Fifty years of my protein synthesis (2002) (0)
Chemical Synthesis of Proteins: Strategy, Scope, and Limitation (2000) (0)
STUDY OF THE SYNTHESIS OF HISTIDINE PEPTIDES. II. USE OF NIM‐TOSYLHISTIDINE DERIVATIVES IN CONVENTIONAL SOLUTION SYNTHESIS OF PEPTIDES (1976) (0)
Structure-activity relationships of alpha-human atrial natriuretic peptide. (1988) (0)
Syntheses of peptides containing proline,pt.1. (1961) (0)
Synthesis of γ-carboxyglutamic acid-containing peptides by the Boc strategy (2009) (0)
Total Synthesis of Porcine Cholecystokinin-33 (CCK-33). (1987) (0)
[Clinical application of an angiotension II analogue]. (1973) (0)
Binding of synthetic beta-human atrial natriuretic peptide to cultured rat vascular smooth muscle cells. (1987) (0)
[New endogenous "big" enkephalins (author's transl)]. (1981) (0)
Directions for solving the remaining problems in the synthesis of large peptides (1999) (0)
Polypeptide, and method for its preparation (1976) (0)
New peptide derivatives and methods for measurement of collagenaseaktivitaet using these compounds (1977) (0)
A new orally active hypotensive peptide, N-(dibenzyloxyphosphinoyl)-L-alanyl-L-prolyl-L-proline (PAPP). (1984) (0)
STUDIES ON THE SYNTHESIS OF HISTIDINE PEPTIDES PART 1, N(IM)‐TOSYLHISTIDINE DERIVATIVES AS STARTING MATERIALS (1975) (0)
Application of N^ -Cyclohexyloxycarbonyltryptophan to Peptide Synthesis (1995) (0)
Nin-Cyclohexyloxycarbonyl Group as a New Protecting Group for Tryptophan. (1997) (0)
Solution synthesis of human midkine, a 121-residue peptide with five disulfide bonds (1995) (0)
Aspartate Racemization in Synthetic Peptides. Part 2. Tendency to Racemization of Aminosuccinyl Residue. (1992) (0)
Changes in Urinary Activity of Dipeptidyl-Aminopeptidase IV:X-Prolyl Dipeptidyl-Aminopeptidase in Renal Diseases (1979) (0)
[Chemical synthesis of proteins]. (1995) (0)
OXYTOCIN ANALOGUES CONTAINING NO DISULFIDE BAND PART 3, THE SYNTHESIS OF THREE ANALOGUES OF 1,6‐AMINOSUBERIC ACID‐OXYTOCIN (1974) (0)
Vasopressor effects of Arg-Phe-containing peptides and N-terminal fragments of human adrenomedullin (1998) (0)
The conformation of conotoxin MI and related peptides (1991) (0)
Nimベンジルオキシメチル(BOM)基の除去過程における副反応 (1991) (0)
[Determination and clinical application of the lecithin/sphingomyelin ratio in amniotic fluid by high performance liquid chromatography]. (1988) (0)
Derivatives of amino acids and antihypertensive drug containing them. (1983) (0)
Solution Synthesis of Calcicludine (CaC) : A Potent Blocker of an L-subtype of Neuronal Ca^ Channels (1995) (0)
Side Reaction in Peptide Synthesis: Modification of Tryptophan During Treatment with Mercury(II) Acetate/2-Mercaptoethanol in Aqueous Acetic Acid. (1994) (0)
Biological activities of endothelin and related peptides (1989) (0)
Solution-phase synthesis of the K+ channel blocker, charybdotoxin (1991) (0)
[Synthesis of peptides by solid phase method. 1]. (1971) (0)
Combined solid-phase and solution approach to protein synthesis (1999) (0)
Biological activities of α-human atrial natriuretic polypeptide (α-hANP)analogs (1986) (0)
An Infrared Absorption Study of Powerful Solvent Systems Useful for the Solution Synthesis of Sparingly Soluble Peptides (1995) (0)
New dipeptide derivatives and their salts, as well as methods for measurement of enzymaktivitaet using these dipeptide derivatives (1976) (0)
Solution synthesis of the L-type specific calcium channel blocker, calciseptine (1993) (0)
Solution synthesis and structure revision of dendrotoxin I (2002) (0)
Studies on dehydroalanine derivatives,pt.3〜5. (1961) (0)
Biological activities of (α-human atrial natriuretic polypeptide (α-hANP) and related peptides. (1985) (0)
Peptide derivatives of 7-amino-4methylcumarins (1979) (0)
Synthesis of gamma-carboxyglutamic acid-containing peptides by the Boc strategy. (1993) (0)
[Synthesis of peptides by the solid phase method. 2]. (1971) (0)
Editorial: Chemical synthesis of proteins (1999) (0)
Toward the Total Synthesis of Proteins (1995) (0)
Book Review: Peptides: Chemistry and Biology. By Norbert Sewald and Hans‐Dieter Jakubke (2003) (0)
On the Synthesis of a Hemopeptide (1964) (0)
Total Synthesis of Aequorea Green Fluorescent Protein (1998) (0)
Solution synthesis of peptides (1999) (0)
Solution Structure of α-Conotoxin SI Determined by Two-Dimensional NMR Spectroscopy (1996) (0)
CRYSTAL STRUCTURE OF ELAFIN COMPLEXED WITH PORCINE PANCREATIC ELASTASE (1997) (0)
Solution conformation of conotoxin gi (1987) (0)

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