Shigeru Sassa

Q: What Schools Are Affiliated With Shigeru Sassa

Shigeru Sassa is affiliated with the following schools: Tohoku University, Kansai Medical University, Rockefeller University, Cornell University, Okayama Prefectural University, Okayama University

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Shigeru Sassa

Physics

#5196

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#6993

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Biophysics

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World Rank

#193

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Physics

Shigeru Sassa's Degrees

PhD Physics University of Tokyo

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Shigeru Sassa's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Heme mediates derepression of Maf recognition element through direct binding to transcription repressor Bach1 (2001) (490)
Delta-aminolevulinic acid dehydratase assay. (1982) (422)
The porphyrias (2002) (390)
Identification of a Human Heme Exporter that Is Essential for Erythropoiesis (2004) (390)
Sequential induction of heme pathway enzymes during erythroid differentiation of mouse Friend leukemia virus-infected cells (1976) (263)
Effects by heme, insulin, and serum albumin on heme and protein synthesis in chick embryo liver cells cultured in a chemically defined medium, and a spectrofluorometric assay for porphyrin composition. (1975) (258)
Positional cloning of the zebrafish sauternes gene: a model for congenital sideroblastic anaemia (1998) (241)
Drug metabolism by the human hepatoma cell, Hep G2. (1987) (190)
Heme oxygenase-1: a novel therapeutic target in oxidative tissue injuries. (2004) (187)
Studies in lead poisoning. II. Correlation between the ratio of activated to inactivated delta-aminolevulinic acid dehydratase of whole blood and the blood lead level. (1973) (186)
Modern diagnosis and management of the porphyrias (2006) (181)
Establishment and characterization of an erythropoietin-dependent subline, UT-7/Epo, derived from human leukemia cell line, UT-7. (1993) (181)
Studies in lead poisoning. I. Microanalysis of erythrocyte protoporphyrin levels by spectrophotometry in the detection of chronic lead intoxication in the subclinical range. (1973) (163)
Lead Binding to δ-Aminolevulinic Acid Dehydratase (ALAD) in Human Erythrocytes (1997) (159)
A zebrafish model for hepatoerythropoietic porphyria (1998) (138)
Assays for porphyrins, delta-aminolevulinic-acid dehydratase, and porphyrinogen synthetase in microliter samples of whole blood: applications to metabolic defects involving the heme pathway. (1972) (135)
Purification and properties of bovine spleen heme oxygenase. Amino acid composition and sites of action of inhibitors of heme oxidation. (1982) (130)
Why Heme Needs to Be Degraded to Iron, Biliverdin IXα, and Carbon Monoxide? (2004) (125)
Induction of aminolevulinate synthase and porphyrins in cultured liver cells maintained in chemically defined medium. Permissive effects of hormones on induction process. (1977) (117)
Hereditary tyrosinemia and the heme biosynthetic pathway. Profound inhibition of delta-aminolevulinic acid dehydratase activity by succinylacetone. (1983) (115)
Purification and properties of uroporphyrinogen decarboxylase from human erythrocytes. A single enzyme catalyzing the four sequential decarboxylations of uroporphyrinogens I and III. (1983) (112)
The role of heme in gene expression. (1996) (110)
Heme deficiency in erythroid lineage causes differentiation arrest and cytoplasmic iron overload (1999) (109)
Induction of -aminolevulinic acid synthetase in chick embryo liver cells in cluture. (1970) (101)
Interleukin-6 down regulates the expression of transcripts encoding cytochrome P450 IA1, IA2 and IIIA3 in human hepatoma cells. (1992) (98)
Molecular aspects of the inherited porphyrias (2000) (92)
Heme biosynthesis in bacterium-protozoon symbioses: enzymic defects in host hemoflagellates and complemental role of their intracellular symbiotes. (1975) (91)
A microassay for uroporphyrinogen I synthase, one of three abnormal enzyme activities in acute intermittent porphyria, and its application to the study of the genetics of this disease. (1974) (89)
Porphyria cutanea tarda associated with the acquired immune deficiency syndrome (1987) (87)
Why heme needs to be degraded to iron, biliverdin IXalpha, and carbon monoxide? (2004) (83)
Genetic Rescue of Leishmania Deficiency in Porphyrin Biosynthesis Creates Mutants Suitable for Analysis of Cellular Events in Uroporphyria and for Photodynamic Therapy* (2002) (82)
Regulation of NF-E2 Activity in Erythroleukemia Cell Differentiation* (1998) (82)
EFFECT OF LEAD AND GENETIC FACTORS ON HEME BIOSYNTHESIS IN THE HUMAN RED CELL * (1975) (80)
Heme oxygenase is a positive acute-phase reactant in human Hep3B hepatoma cells. (1992) (80)
Erythroleukemia differentiation. Distinctive responses of the erythroid-specific and the nonspecific delta-aminolevulinate synthase mRNA. (1991) (80)
Heme biosynthesis and drug metabolism in mice with hereditary hemolytic anemia. Heme oxygenase induction as an adaptive response for maintaining cytochrome P-450 in chronic hemolysis. (1979) (78)
Interaction between succinyl CoA synthetase and the heme-biosynthetic enzyme ALAS-E is disrupted in sideroblastic anemia. (2000) (78)
The potent heme oxygenase inducing action of arsenic and parasiticidal arsenicals. (1981) (78)
Heme oxygenase-1: a fundamental guardian against oxidative tissue injuries in acute inflammation. (2007) (76)
The molecular defect of ferrochelatase in a patient with erythropoietic protoporphyria. (1992) (74)
Complementation analysis of mutants of nitric oxide synthase reveals that the active site requires two hemes. (1996) (72)
CHAPTER 4 – δ-Aminolevulinic Acid Synthetase and the Control of Heme and Chlorophyll Synthesis*† (1971) (72)
Studies in porphyria. IV. Expression of the gene defect of acute intermittent porphyria in cultured human skin fibroblasts and amniotic cells: prenatal diagnosis of the porphyric trait (1975) (71)
Inducible nitric oxide synthase: identification of amino acid residues essential for dimerization and binding of tetrahydrobiopterin. (1995) (70)
Protective role of heme oxygenase-1 in the intestinal tissue injury in an experimental model of sepsis (2003) (69)
Hemin control of heme biosynthesis in mouse Friend virus-transformed erythroleukemia cells in culture. (1978) (68)
Inhibition of dimethyl sulfoxide-stimulated Friend cell erythrodifferentiation by hydrocortisone and other steroids. (1978) (66)
Heme binding to murine erythroleukemia cells. Evidence for a heme receptor. (1985) (65)
The lower intestinal tract-specific induction of heme oxygenase-1 by glutamine protects against endotoxemic intestinal injury* (2005) (65)
Suppression of cytochrome P450IA1 by interleukin-6 in human HepG2 hepatoma cells. (1994) (65)
Lead intoxication: Effects on cytochrome P‐450‐mediated hepatic oxidations (1976) (63)
Acylpeptide hydrolase: inhibitors and some active site residues of the human enzyme. (1992) (61)
The role of inorganic metals and metalloporphyrins in the induction of haem oxygenase and heat-shock protein 70 in human hepatoma cells. (1993) (61)
Increased erythrocyte uroporphyrinogen-l-synthetase, delta-aminolevulinic acid dehydratase and protoporphyrin in hemolytic anemias. (1977) (61)
Protective role of heme oxygenase-1 in renal ischemia. (2004) (60)
Lead binding to delta-aminolevulinic acid dehydratase (ALAD) in human erythrocytes. (1997) (60)
The liver excretes large amounts of heme into bile when heme oxygenase is inhibited competitively by Sn-protoporphyrin. (1985) (60)
Prevention of cyclical attacks of acute intermittent porphyria with a long-acting agonist of luteinizing hormone-releasing hormone. (1984) (59)
Tumor promoter-mediated inhibition of cell differentiation: suppression of the expression of erythroid functions in murine erythroleukemia cells. (1979) (58)
Studies on the inheritance of human erythrocyte delta-aminolevulinate dehydratase and uroporphyrinogen synthetase. (1973) (57)
Heat shock induction of heme oxygenase mRNA in human Hep 3B hepatoma cells. (1989) (56)
Cytoprotective effects of heme oxygenase in acute renal failure. (2005) (56)
Sequential activation of genes for heme pathway enzymes during erythroid differentiation of mouse Friend virus-transformed erythroleukemia cells. (1991) (54)
Cloning and expression of the defective genes from a patient with delta-aminolevulinate dehydratase porphyria. (1992) (53)
Deficiency of acylpeptide hydrolase in small-cell lung carcinoma cell lines. (1992) (52)
A comparative study of heme degradation by NADPH-cytochrome c reductase alone and by the complete heme oxygenase system. Distinctive aspects of heme degradation by NADPH-cytochrome c reductase. (1982) (51)
Toxic Effects of Lead, with Particular Reference to Porphyrin and Heme Metabolism (1978) (51)
Biological Implications of Heme Metabolism (2006) (49)
Aberrant iron accumulation and oxidized status of erythroid-specific delta-aminolevulinate synthase (ALAS2)-deficient definitive erythroblasts. (2003) (49)
Metal ion-mediated regulation of heme oxygenase induction in cultured avian liver cells. (1982) (47)
Genetic, metabolic, and biochemical aspects of the porphyrias. (1981) (46)
Hepatoerythropoietic porphyria: clinical, biochemical, and enzymatic studies in a three-generation family lineage. (1987) (46)
Expression of cytochrome P450 mRNAs in the colon and the rectum in normal human subjects. (1995) (45)
The occurrence of molecular interactions among NADPH-cytochrome c reductase, heme oxygenase, and biliverdin reductase in heme degradation. (1982) (45)
Effects of polychlorinated biphenyl compounds, 2,3,7,8-tetrachlorodibenzo-p-dioxin, phenobarbital and iron on hepatic uroporphyrinogen decarboxylase. Implications for the pathogenesis of porphyria. (1983) (44)
A Protective Role of Interleukin 11 on Hepatic Injury in Acute Endotoxemia (2004) (44)
Deficient heme and globin synthesis in embryonic stem cells lacking the erythroid-specific delta-aminolevulinate synthase gene. (1998) (43)
Activation of heme oxygenase and heat shock protein 70 genes by stress in human hepatoma cells. (1990) (42)
Steroid induction of delta-aminolevulinic acid synthase and porphyrins in liver. Structure-activity studies and the permissive effects of hormones on the induction process. (1979) (41)
Some biochemical and clinical aspects of lead intoxication. (1978) (41)
Studies in porphyria. VIII. Relationship of the 5 alpha-reductive metabolism of steroid hormones to clinical expression of the genetic defect in acute intermittent porphyria. (1979) (40)
Fundamental role of heme oxygenase in the protection against ischemic acute renal failure. (2002) (40)
Heme stimulation of cellular growth and differentiation. (1988) (39)
Studies in porphyria; v. Drug oxidation rates in hereditary hepatic porphyria (1976) (39)
Tin-protoporphyrin suppression of hyperbilirubinemia in mutant mice with severe hemolytic anemia. (1983) (38)
Marked developmental changes in heme oxygenase-1 (HO-1) expression in the mouse placenta: correlation between HO-1 expression and placental development. (2004) (37)
Five new mutations in the uroporphyrinogen decarboxylase gene identified in families with cutaneous porphyria. (1996) (37)
Erythrocyte uroporphyrinogen decarboxylase activity in porphyria cutanea tarda: a study of 40 consecutive patients. (1989) (37)
Regulation of the genes for heme pathway enzymes in erythroid and in non-erythroid cells. (1990) (36)
delta-Aminolaevulinate synthase in human HepG2 hepatoma cells. Repression by haemin and induction by chemicals. (1989) (36)
Effects of metalloporphyrins on hemoglobin formation in mouse Friend virus-transformed erythroleukemia cells. Stimulation of heme biosynthesis by cobalt protoporphyrin. (1982) (36)
Biochemical Studies of a Patient with Hereditary Hepatorenal Tyrosinemia: Evidence of Glutathione Deficiency (1984) (36)
Diagnosis and therapy of acute intermittent porphyria. (1996) (36)
Regulation of erythropoiesis in the Friend leukemia mouse. (1968) (36)
The influence of steroid hormone metabolites on the in vitro development of erythroid colonies derived from human bone marrow (1979) (36)
Hereditary tyrosinemia. Formation of succinylacetone-amino acid adducts (1985) (35)
The origin of the increased protoporphyrin in erythrocytes of mice with experimentally induced porphyria. (1967) (35)
The oxidative degradation of heme c by the microsomal heme oxygenase system. (1982) (34)
Effect of interleukin-11 on the levels of mRNAs encoding heme oxygenase and haptoglobin in human HepG2 hepatoma cells. (1993) (33)
Analysis of porphyrin carboxylic acids in biological fluids by high-performance liquid chromatography. (1982) (33)
Studies on porphyrin-heme biosynthesis in organotypic cultures of chick dorsal root ganglion. I. Observations on neuronal and non-neuronal elements. (1978) (33)
The role of the erythroid-specific delta-aminolevulinate synthase gene expression in erythroid heme synthesis. (1995) (32)
Highly heterogeneous nature of delta-aminolevulinate dehydratase (ALAD) deficiencies in ALAD porphyria. (2001) (32)
Flavohemoglobin: a semisynthetic hydroxylase acting in the absence of reductase (1987) (32)
Lead poisoning from "do-it-yourself" heat guns for removing lead-based paint: Report of two cases (1981) (31)
Late-onset X-linked sideroblastic anemia following hemodialysis. (2003) (31)
The third case of Doss porphyria (δ-amino-levulinic acid dehydratase deficiency) in Germany (2004) (31)
delta-Aminolevulinate dehydratase (ALAD) porphyria: the first case in North America with two novel ALAD mutations. (2006) (31)
Photosensitivity, abnormal porphyrin profile, and sideroblastic anemia. (1992) (31)
A heat-inducible nuclear factor that binds to the heat-shock element of the human haem oxygenase gene. (1991) (31)
5-Aminolevulinic acid dehydratase deficiency porphyria: a twenty-year clinical and biochemical follow-up. (1998) (30)
Studies in porphyria: functional evidence for a partial deficiency of ferrochelatase activity in mitogen-stimulated lymphocytes from patients with erythropoietic protoporphyria. (1982) (30)
Inhibition of the growth and differentiation of erythroid precursor cells by an endotoxin-induced mediator from peritoneal macrophages. (1983) (29)
Characterization and expression of cDNA encoding coproporphyrinogen oxidase from a patient with hereditary coproporphyria. (1994) (29)
Molecular basis of variegate porphyria: a de novo insertion mutation in the protoporphyrinogen oxidase gene (1996) (29)
Porphyrogenic effects and induction of heme oxygenase in vivo by δ-aminolevulinic acid (1981) (28)
A novel MPL point mutation resulting in thrombopoietin-independent activation (2002) (28)
The rapid and decremental change in haem oxygenase mRNA during erythroid differentiation of murine erythroleukaemia cells (1989) (28)
Different responses of the hepatic and erythropoietic σ-aminolevulinic acid synthetase of mice (1967) (28)
Studies of the influence of chloro-substituent sites and conformational energy in polychlorinated biphenyls on uroporphyrin formation in chick-embryo liver cell cultures. (1986) (27)
Hematologic aspects of the porphyrias. (2000) (27)
A novel mutation of the erythroid‐specific δ‐aminolaevulinate synthase gene in a patient with X‐linked sideroblastic anaemia (1999) (27)
THE EFFECT OF ALA AND RADIATION ON PORPHYRIN/HEME BIOSYNTHESIS IN ENDOTHELIAL CELLS (1995) (27)
Leishmania spp.: delta-aminolevulinate-inducible neogenesis of porphyria by genetic complementation of incomplete heme biosynthesis pathway. (2008) (27)
Hormonal regulation of heme oxygenase induction in avian hepatocyte culture. (1985) (26)
Long-term administration of massive doses of Sn-protoporphyrin in anemic mutant mice (sphha/sphha) (1985) (25)
Phenotypic variation in human HepG2 hepatoma cells: alterations in cell growth, plasma protein synthesis and heme pathway enzymes. (1990) (24)
Partial purification of cytochrome P450 from rat brain and demonstration of estradiol hydroxylation. (1987) (24)
Purification and properties of human erythrocyte uroporphyrinogen decarboxylase: immunological demonstration of the enzyme defect in porphyria cutanea tarda. (1983) (24)
Abnormal serum porphyrin levels in patients with the acquired immunodeficiency syndrome with or without hepatitis C virus infection. (1996) (24)
Porphyrias in Japan: Compilation of All Cases Reported through 2002 (2004) (24)
Porphyrin-heme biosynthesis in organotypic cultures of mouse dorsal root ganglia. Effects of heme and lead on porphyrin synthesis and peripheral myelin. (1984) (24)
Molecular analysis of delta-aminolevulinate dehydratase deficiency in a patient with an unusual late-onset porphyria. (2000) (23)
Plumbism from airborne lead in a firing range. An unusual exposure to a toxic heavy metal. (1977) (23)
Studies in porphyria. VII. Induction of uroporphyrinogen-I synthase and expression of the gene defect of acute intermittent porphyria in mitogen-stimulated human lymphocytes. (1978) (22)
Highly liver-specific heme oxygenase-1 induction by interleukin-11 prevents carbon tetrachloride-induced hepatotoxicity. (2006) (22)
Uroporphyrinogen I synthase induction in normal human bone marrow cultures: an early and quantitative response of erythroid differentiation. (1979) (22)
Regulation of beta-globin mRNA accumulation by heme in dimethyl sulfoxide (DMSO)-sensitive and DMSO-resistant murine erythroleukemia cells (1994) (22)
Transgenic Leishmania Model for Delta-Aminolevulinate-Inducible Monospecific Uroporphyria: Cytolytic Phototoxicity Initiated by Singlet Oxygen-Mediated Inactivation of Proteins and Its Ablation by Endosomal Mobilization of Cytosolic Uroporphyrin (2008) (21)
Dual gene defects involving δ‐aminolaevulinate dehydratase and coproporphyrinogen oxidase in a porphyria patient (2006) (21)
Proof that Sn-protoporphyrin inhibits the enzymatic catabolism of heme in vivo. Suppression of 14CO generation from radiolabeled endogenous and exogenous heme sources (1987) (21)
5-Aminolevulinate synthase expression and hemoglobin synthesis in a human myelogenous leukemia cell line. (1997) (20)
Induction of haem synthesis in Hep G2 human hepatoma cells by dimethyl sulphoxide. A transcriptionally activated event. (1986) (20)
delta-Aminolevulinate dehydratase in human erythroleukemia cells: an immunologically distinct enzyme. (1985) (20)
Cytochrome P-450C-M/F, a new constitutive form of microsomal cytochrome P-450 in male and female rat liver with estrogen 2- and 16 alpha-hydroxylase activity. (1988) (20)
Levels of delta-aminolevulinate dehydratase, uroporphyrinogen-I synthase, and protoporphyrin IX in erythrocytes from anemic mutant mice. (1977) (20)
Dimethyl sulphoxide and haemin induce ferrochelatase mRNA by different mechanisms in murine erythroleukaemia cells (1993) (19)
Multiple mechanisms for hereditary sideroblastic anemia. (2002) (19)
R411C mutation of the ALAS2 gene encodes a pyridoxine‐responsive enzyme with low activity (1998) (19)
Hypoxia decreases the expression of the two enzymes responsible for producing linear and cyclic tetrapyrroles in the heme biosynthetic pathway (2008) (19)
A novel mutation of the erythroid‐specific δ‐aminolevulinate synthase gene in a patient with non‐inherited pyridoxine‐responsive sideroblastic anemia (1999) (19)
Regulation of 5-aminolevulinate synthase in mouse erythroleukemic cells is different from that in liver. (1988) (19)
How genetic defects are identified. (1998) (19)
Enzymatic defect in a child with hereditary hepatic porphyria due to homozygous delta-aminolevulinic acid dehydratase deficiency: immunochemical studies. (1987) (19)
Adrenalectomy enhances the induction of heme oxygenase and the degradation of cytochrome P-450 in liver. (1980) (18)
Lead intoxication among demolition workers: the effect of lead on the hepatic cytochrome P-450 system in humans. (1977) (18)
Development of porphyria cutanea tarda after treatment with cyclophosphamide. (1988) (18)
Succinylacetone inhibits delta-aminolevulinate dehydratase and potentiates the drug and steroid induction of delta-aminolevulinate synthase in liver. (1982) (18)
ALAD porphyria. (1998) (18)
Effects of dimethyl sulphoxide on the synthesis of plasma proteins in the human hepatoma HepG2. Induction of an acute-phase-like reaction. (1988) (18)
Early-stage HIV infection and hepatitis C virus infection are associated with elevated serum porphyrin levels. (1998) (17)
An immunological study of delta-aminolevulinic acid dehydratase specificity consistent with the phylogeny of species. (1984) (17)
Novel effects of heme and heme-related compounds in biological systems (1996) (17)
Four species of cDNAs for cytochrome P450 isozymes immunorelated to P450C-M/F encode for members of P450IID subfamily, increasing the number of members within the subfamily. (1988) (17)
Lead poisoning in an art conservator. (1982) (17)
The occurrence of substances in human plasma capable of inducing the enzyme delta-aminolevulinate synthetase in liver cells. (1969) (17)
Accumulation of protoporphyrin IX from delta-aminolevulinic acid in bovine skin fibroblasts with hereditary erythropoietic protoporphyria. A gene-dosage effect (1981) (17)
Cimetidine in the treatment of porphyria cutanea tarda. (1996) (17)
Oxidative stress is involved in hydroxyurea‐induced erythroid differentiation (2003) (17)
Stimulators and inhibitors of hepatic porphyrin formation in human sera. (1974) (16)
Preparation and properties of a solubilized form of cytochrome P-450 from chick embryo liver microsomes. (1971) (16)
Lead poisoning from art restoration and pottery work: unusual exposure source and household risk. (1992) (16)
Metabolism of estradiol in liver cell culture. Differential responses of C-2 and C-16 oxidations to drugs and other chemicals that induce selective species of cytochrome P-450. (1983) (16)
Immunochemical study of uroporphyrinogen decarboxylase in a patient with mild hepatoerythropoietic porphyria. (1987) (16)
Fluorometric measurement of tin-protoporphyrin in biological samples. (1984) (16)
The effect of erythropoietin on human bone marrow cells in vitro. I. Studies of nine cases of bone marrow failure. (1971) (16)
Succinylacetone and delta-aminolevulinic acid dehydratase in hereditary tyrosinemia: immunochemical study of the enzyme. (1990) (16)
Novel molecular defects of the δ‐aminolevulinate dehydratase gene in a patient with inherited acute hepatic porphyria (2000) (15)
Novel regulation of δ-aminolevulinate synthase in the rat harderian gland (1997) (15)
The effect of erythropoietin on hematopoietic organs of the polycythemic mouse. (1966) (15)
Message amplification phenotyping of an inherited delta-aminolevulinate dehydratase deficiency in a family with acute hepatic porphyria. (1990) (15)
The effects of early treatment of hereditary tyrosinemia type I in infancy by orthotopic liver transplantation. (1990) (14)
Inhibition of erythroid differentiation of mouse erythroleukemia cells by a macrophage product(s). (1987) (14)
The third case of Doss porphyria (delta-amino-levulinic acid dehydratase deficiency) in Germany. (2004) (14)
Hereditary hepatic porphyria due to homozygous δ‐aminolevulinic acid dehydratase deficiency: studies in lymphocytes and erythrocytes (1991) (14)
Late-onset porphyrias: what are they? (2002) (13)
Induction of delta-aminolevulinic acid dehydratase in mouse Friend virus-transformed erythroleukemia cells during erythroid differentiation. (1984) (13)
Arg452 substitution of the erythroid‐specific 5‐aminolaevulinate synthase, a hot spot mutation in X‐linked sideroblastic anaemia, does not itself affect enzyme activity (2006) (13)
Haem is necessary for a continued increase in ferrochelatase mRNA in murine erythroleukaemia cells during erythroid differentiation (1993) (13)
DNA fragments in Friend erythroleukemia cells induced by dimethyl sulfoxide. (1983) (13)
ADP-ribosyltransferase activity during the friend virus-induced murine erythroleukemia cell differentiation. (1983) (12)
The effects of acute-phase inducers and dimethyl sulphoxide on delta-aminolaevulinate synthase activity in human HepG2 hepatoma cells. (1989) (12)
PROFOUND INHIBITION OF 8-AMINOLEVULINIC ACID DEHYDRATASE ACTIVITY BY SUCCINYLACETONE (1983) (12)
CYP2E1 overexpression up-regulates both non-specific delta-aminolevulinate synthase and heme oxygenase-1 in the human hepatoma cell line HLE/2E1. (2003) (12)
Differential gene expression profiling between wild-type and ALAS2-null erythroblasts: identification of novel heme-regulated genes. (2006) (12)
Analysis of porphyrins and enzymes in porphyrin synthesis in Taenia solium cysticercus from man and pig. (1987) (12)
Assignment of the gene for uroporphyrinogen decarboxylase to human chromosome 1 by somatic cell hybridization and specific enzyme immunoassay (2004) (12)
Regulation of heme synthesis in HepG2 human hepatoma cells by dimethyl sulfoxide. (1988) (12)
Porphyrin synthesis by murine epidermal cells. (1993) (11)
Regulation of Heme Biosynthesis in Mouse Friend Virus-Transformed Cells in Culture (1978) (11)
Childhood-onset familial porphyria cutanea tarda: effects of therapeutic phlebotomy. (1992) (11)
Delta-Aminolevulinate-Induced Host-Parasite Porphyric Disparity for Selective Photolysis of Transgenic Leishmania in the Phagolysosomes of Mononuclear Phagocytes: a Potential Novel Platform for Vaccine Delivery (2012) (10)
Aromatization and 19-hydroxylation of androgens by rat brain cytochrome P-450. (1988) (10)
Heme oxygenase‐1: a new drug target in oxidative tissue injuries in critically ill conditions (2006) (10)
Molecular defects of the coproporphyrinogen oxidase gene in hereditary coproporphyria. (1997) (9)
Defense Against Oxidative Tissue Injury: The Essential Role Played by Heme Oxygenase-1 (2006) (9)
Differential responses to inducers of delta-aminolaevulinate synthase and haem oxygenase during pregnancy. (1981) (9)
Heme synthesis in normal and leukemic leukocytes. (1968) (9)
The effect of porphyrin and radiation on ferrochelatase and 5‐aminolevulinic acid synthase in epidermal cells (1995) (8)
Recent progress in heme synthesis and metabolism (1994) (8)
Tin-protoporphyrin inhibits heme oxygenase and prevents the decline in hepatic heme and cytochrome P-450 contents produced in nude mice by tumor transplantation. (1988) (8)
Three new mutations in the uroporphyrinogen decarboxylase gene in familial porphyria cutanea tarda (1999) (8)
Studies on porphyrin-heme biosynthesis in organotypic cultures of chick dorsal root ganglia. II. The effect of lead. (1979) (8)
Endocrine-gene interaction in the pathogenesis of acute intermittent porphyria. (1974) (7)
Inhibition of carbon monoxide production by tin-protoporphyrin. (1987) (7)
Lead hazard among ironworkers. Dismantling lead-painted elevated subway line in New York City. (1978) (7)
An acquired acute hepatic porphyria: A novel type of δ-aminolevulinate dehydratase inhibition (1992) (7)
Survival of two patients with severe δ-aminolaevulinic acid dehydratase deficiency porphyria (2001) (7)
Heme Synthesis in Friend Ascites Tumor Cells∗ (1968) (6)
Heme Oxygenase-1 (2002) (6)
Porphyrogenic effects and induction of heme oxygenase in vivo by delta-aminolevulinic acid. (1981) (6)
Semimicroassay method for hepatic delta-aminolevulinic acid synthetase activity. (1970) (6)
The effect of dimethyl sulfoxide on heme synthesis and the acute phase reaction in human HepG2 hepatoma cells. (1989) (6)
Deficient induction of uroporphyrinogen-I synthase activity in mitogen-stimulated lymphocytes from patients with acute intermittent porphyria. (1977) (6)
Gene-environmental interactions: Lessons from porphyria (2003) (5)
Disorders of heme biosynthesis — The porphyrias (1991) (5)
Regulation of beta-globin mRNA accumulation by heme in dimethyl sulfoxide (DMSO)-sensitive and DMSO-resistant murine erythroleukemia cells. (1994) (5)
Studies in porphyria IX: Detection of the gene defect of erythropoietic protoporphyria in mitogen-stimulated human lymphocytes. (1979) (5)
Novel regulation of delta-aminolevulinate synthase in the rat harderian gland. (1997) (5)
Studies of erythrocyte protoporphyrin in anemic mutant mice: use of a modified hematofluorometer for the detection of heterozygotes for hemolytic disease. (1978) (5)
Differential induction responses of δ‐aminolevulinate synthase mRNAs during erythroid differentiation: Use of nonradioactive in situ hybridization (1992) (4)
Genetic Regulation of the Heme Pathway a (1987) (4)
A comparison of the utility of Dowex resin and polybenzimidazole Aurorez resin in the determination of urinary porphobilinogen concentrations. (1987) (4)
Prenatal diagnosis of acute intermittent porphyria. (1976) (4)
Cytochrome P450CMF cDNA: nucleotide sequence of P450CMF1b. (1989) (4)
Chloro-substituent sites and probability of co-planarity in polychlorinated biphenyls in determining uroporphyrin formation in cultured liver cells. (1986) (4)
Effect of soluble complement receptor type 1 on porphyrin-induced phototoxicity in guinea pigs. (1998) (4)
Growth hormone stimulates drug-induced porphyrin formation in liver cells maintained in a serum-free medium. (1981) (4)
Akagi R, Inoue R, Muranaka S et al.Dual gene defects involving δ-aminolaevulinate dehydratase and coproporphyrinogen oxidase in a porphyria patient. Br J Haematol 132:237-243 (2006) (4)
Immunochemical detection of cytochrome P450C-M/F and NADPH-cytochrome P450 reductase in rat liver and kidney. (1988) (3)
Sequential induction of enzymes in the heme biosynthetic pathway during erythroid differentiation. (1975) (3)
Lack of effect of pregnancy or hematin therapy on erythrocyte porphobilinogen deaminase activity in acute intermittent porphyria. (1989) (3)
Three new mutations in the uroporphyrinogen decarboxylase gene in familial porphyria cutanea tarda. Mutation in brief no. 237. Online. (1999) (3)
[Gene regulation by free heme]. (2007) (3)
Heme Synthesis Pathway (2001) (2)
STUDIES OF PORPHYRIN BIOSYNTHESIS AND LEAD EFFECT IN ORGANOTYPIC CULTURES OF CHICK DORSAL ROOT GANGLION: 140 (1977) (2)
Increased lead absorption in a potter and her family members. (1991) (2)
Studies on Erythroid Differentiation in a Wild-Type and Dimethylsulfoxide-Resistant Clones of Friend Virus-Transformed Cells: Effects of Hemin, Hemoglobin, Erythropoietin (1978) (2)
Survival of two patients with severe delta-aminolaevulinic acid dehydratase deficiency porphyria. (2001) (2)
Induction of Uroporphyrinogen-I Synthase Activity in Mitogen-Stimulated Lymphocytes: Deficient Induction in Acute Intermittent Porphyria Cells (1978) (1)
[The busulfan therapy of chronic granulocytic leukemia]. (1969) (1)
Different responses of the hepatic and erythropoietic delta-aminolevulinic acid synthetase of mice. (1967) (1)
Levels of 6-aminolevulinate dehydratase , uroporphyrinogen-I synthase , and protoporphyrin IX in erythrocytes from anemic mutant mice ( hemolytic disease / reticulocytosis / heme biosynthesis / development ) (1)
Transcriptional Activation of the Human Heme Oxygenase-1 Gene during Acute-Phase Reaction (1996) (1)
Expression of the Gene Defects of Acute Intermittent Porphyria (AIP) and Erythropoietic Protoporphyria (EPP) in Mitogen-Stimulated Lymphocytes (1978) (1)
046 Serum porphyrin study in patients with HIV infection (1995) (1)
STUDIES ON EFFECTS OF CHRONIC LEAD EXPOSURE UPON PORPHYRIN BIOSYNTHESIS AND MYELIN IN CULTURE OF MOUSE DORSAL, ROOT GANGLIA (DRG): 142 (1979) (1)
Cloning and expression of the defective genes in delta-aminolevulinate dehydratase porphyria: compound heterozygosity in this hereditary liver disease. (1992) (1)
[CASE OF DISSEMINATED EOSINOPHILIC COLLAGENOSIS]. (1964) (0)
Hepatic drug oxidations in expressed and latent forms of acute intermittent porphyria (1975) (0)
[Significance of porphobilinogen deaminase analysis in clinical tests]. (1989) (0)
[Significance of delta-aminolevulinic acid dehydratase analysis in clinical tests]. (1989) (0)
-aminolevulinate synthase (ALAS2)-deficient definitive erythroblasts δ Aberrant iron accumulation and oxidized status of erythroid-specific (2013) (0)
Inhibition of the growth and differentiation of erythroid precursor cells by an endotoxin-induced mediator from peritoneal macrophages ( cell differentiation / growth inhibition / erythropoiesis / macrophage product ( s ) / murine erythroleukemia cells ) (0)
Tumorpromoter-mediated inhibition ofcell differentiation: Suppression oftheexpression oferythroid functions inmurineerythroleukemia cells (1979) (0)
A Microassay for Uroporphyrinogen I Syl Enzyme Activities in Acute Intermittent P to the Study of the Genetics of this Diseas (2016) (0)
ReviewArtiele Gene-EnvironmentalInteractions : Lessons from Porphyria (2018) (0)
[Significance of porphyrin analysis in clinical tests]. (1989) (0)
[STUDIES ON ERYTHROPOIETIN. 23. EFFECT OF ERYTHROPOIETIN ON HEME SYNTHESIS IN THE SPLEEN]. (1965) (0)
[Autoimmune hemolytic anemia terminating in the aplasia of bone marrow associated with agranulocytosis and leukemoid reaction]. (1967) (0)
[Heme biosynthesis and iron metabolism]. (2003) (0)
Three new mutations in the uroporphyrinogen decarboxylase gene in familial porphyria cutanea tarda Communicated by: Haig H. Kazazian, Jr. Online Citation: Human Mutation, Mutation in Brief #237 (1999) Online http://journals.wiley.com/1059-7794/pdf/mutation/237.pdf (1999) (0)
Novel Effects of Heme Biological Systemst and Heme-related Compounds in Biological Systems (1996) (0)
Acute intermittent porphyria. (1981) (0)
An acquired acute hepatic porphyria: a novel type of delta-aminolevulinate dehydratase inhibition. (1992) (0)
Absence of close linkage between acute intermittent porphyria and the ABO, Rh, P, acid phosphatase, Pr, orosmucoid and pepsinogen loci. (1982) (0)
THE OCCURRENCE OF SUBSTANCES IN HUMAN PLASMl 1 A CAPABLE OF INDUCING THE ENZYMl 4 E 6-AMINOLEVULINA TE SYNTHETASE IN LIVER CELLS (0)
[Significance of delta-aminolevulinic acid synthase analysis in clinical tests]. (1989) (0)
Absence of C282Y and H63D mutations of the hemochromatosis gene in Japanese patients with sideroblastic anemia (1999) (0)
hepatoma cells Heme oxygenase is a positive acute-phase reactant in human Hep 3 (2003) (0)
deficiencies in ALAD porphyria -aminolevulinate dehydratase (ALAD) δ Highly heterogeneous nature of (2013) (0)
[Contribution of Japanese researchers to progress in the field of hematology in the last 100 years: Porphyria/congenital heme synthetase deficiency]. (2002) (0)
Binding of LabeledThyroxin Analogto SerumProteinsEvaluated afterRadloimmunoassay of FreeThyroxin (1989) (0)
“Affenmensch” defect defined (2001) (0)
Stimulation of hepatic porphyrin synthesis in tissue culture by sera of patients with acute porphyria. (1969) (0)
Preface (1999) (0)
A CASE OF “LA COLLAGÉNOSE DISSÉMINEE ÉOSINOPHILIQUE” (1964) (0)
Heme biosynthesis in bacterium-pr defects in host hemoflagellates and intracellular symbiotes (uroporphyrinogen I synthase/isotope incorporation/hemin nutr (1975) (0)
The porphyrias: genetic and acquired aspects. (2001) (0)
[Significance of delta-aminolevulinic acid analysis in clinical tests]. (1989) (0)
Identification of Novel Heme-Regulated Genes during Erythroid Differentiation. (2004) (0)
PROOF THAT Sn-PROTOPORPHYRIN INHIBITS THE ENZYMATIC CATABOLISM OF HEME IN VIVO Suppression of"CO Generation from Radiolabeled Endogenous and (1987) (0)
[Heme synthesis and its abnormality]. (1997) (0)
Evaluation and Comparison of a RadiativeEnergyAttenuation Methodfor Determining Cholesterol in Serum (1985) (0)
1183 GLUTATHIONE IS DEFICIENT IN HEREDITARY TYROSINEMIA (1981) (0)
A Microassay forUroporphyrinogen ISynthase, OneofThreeAbnormal EnzymeActivities inAcuteIntermittent Porphyria, anditsApplication totheStudyoftheGenetics ofthis Disease* (spectrofluorimetry/erythrocytes) (1974) (0)
Suppression of Erythroid-Specific 5-Aminolevulinate Synthase Using Short-Interfering RNA Alters Iron Metabolism and Inhibits Terminal Differentiation of Human Erythroleukemia Cells. (2004) (0)
Inhibition of the growth and differ( cells by an endotoxin-induced medi peritoneal macrophages (cell differentiation/growth inhibition/erythropoiesis/macrophage pl (2016) (0)
Hereditary tyrosinemia is an inborn error of tyrosine metabolism due to an inherited deficiency of fumarylacetoacetate hydrolase activity transmitted in an autosomal recessive fashion (1). This disease is characterized by multiple renal tubular defects accompanied with aminoaciduria and proteinuria, (2003) (0)
Preface (1994) (0)
The porphyrias: genetic and acquired aspects (第42回日本臨床血液学会総会) (2001) (0)
Permissive Effects of Hormones on the Induction of δ-Aminolevulinic Acid Synthase in Cultured Chick-Embryo Liver Cells (1978) (0)
Analyses of Heme-Regulated Genes during Erythoid Differentiation. (2007) (0)

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