Sadaf Farooqi | Academic Influence

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Sadaf Farooqi

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Philosophy

Sadaf Farooqi's Degrees

PhD Medical Sciences University of Oxford

Why Is Sadaf Farooqi Influential?

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According to Wikipedia, Ismaa Sadaf Farooqi is a Wellcome Trust Senior Research fellow in Clinical Science, professor of Metabolism and Medicine at the University of Cambridge and a consultant physician at Addenbrooke's Hospital in Cambridge, UK.

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Sadaf Farooqi's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Congenital leptin deficiency is associated with severe early-onset obesity in humans (1997) (2978)
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index (2010) (2011)
Effects of recombinant leptin therapy in a child with congenital leptin deficiency. (1999) (1870)
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation (2009) (1735)
Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene. (2003) (1511)
Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. (2002) (1459)
The Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase (2007) (1375)
Common variants near MC4R are associated with fat mass, weight and risk of obesity (2008) (1307)
Association analyses of 249,796 individuals reveal eighteen new loci associated with body mass index (2010) (1179)
A frameshift mutation in MC4R associated with dominantly inherited human obesity (1998) (1078)
The UK10K project identifies rare variants in health and disease (2015) (926)
Genetics of body-weight regulation (2000) (780)
Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency. (2000) (759)
Clinical and molecular genetic spectrum of congenital deficiency of the leptin receptor. (2007) (644)
The Hormonal Control of Food Intake (2007) (571)
Leptin Regulates Striatal Regions and Human Eating Behavior (2007) (571)
Genetics of obesity in humans. (2006) (568)
Large, rare chromosomal deletions associated with severe early-onset obesity (2010) (533)
Obesity associated genetic variation in FTO is associated with diminished satiety. (2008) (516)
A de novo mutation affecting human TrkB associated with severe obesity and developmental delay (2004) (515)
Pediatric Obesity-Assessment, Treatment, and Prevention: An Endocrine Society Clinical Practice Guideline. (2017) (486)
Obesity and the brain: how convincing is the addiction model? (2012) (447)
Hyperphagia, Severe Obesity, Impaired Cognitive Function, and Hyperactivity Associated With Functional Loss of One Copy of the Brain-Derived Neurotrophic Factor (BDNF) Gene (2006) (445)
Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension (2013) (429)
Influence of Leptin on Arterial Distensibility: A Novel Link Between Obesity and Cardiovascular Disease? (2002) (417)
Monogenic obesity in humans. (2005) (416)
Serum ghrelin levels are inversely correlated with body mass index, age, and insulin concentrations in normal children and are markedly increased in Prader-Willi syndrome. (2003) (393)
Early childhood infection and atopic disorder (1998) (393)
Metabolism: Partial leptin deficiency and human adiposity (2001) (383)
The central melanocortin system directly controls peripheral lipid metabolism. (2007) (381)
A genome-wide association meta-analysis identifies new childhood obesity loci (2012) (375)
Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations. (2009) (354)
Leptin: a pivotal regulator of human energy homeostasis. (2009) (341)
A mutation in the thyroid hormone receptor alpha gene. (2012) (341)
Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency. (2003) (313)
Safety and immunogenicity of seven COVID-19 vaccines as a third dose (booster) following two doses of ChAdOx1 nCov-19 or BNT162b2 in the UK (COV-BOOST): a blinded, multicentre, randomised, controlled, phase 2 trial (2021) (297)
Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity (2013) (296)
Improved imputation of low-frequency and rare variants using the UK10K haplotype reference panel (2015) (296)
A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism. (2002) (287)
The Hunger Genes: Pathways to Obesity (2015) (284)
Leptin Mediates the Increase in Blood Pressure Associated with Obesity (2014) (283)
Two novel missense mutations in g protein-coupled receptor 54 in a patient with hypogonadotropic hypogonadism. (2005) (275)
Congenital leptin deficiency due to homozygosity for the Delta133G mutation: report of another case and evaluation of response to four years of leptin therapy. (2004) (273)
A deletion of the HBII-85 class of small nucleolar RNAs (snoRNAs) is associated with hyperphagia, obesity and hypogonadism. (2009) (273)
Modulation of blood pressure by central melanocortinergic pathways. (2009) (261)
Mutations in ligands and receptors of the leptin–melanocortin pathway that lead to obesity (2008) (255)
Early nutrition and leptin concentrations in later life. (2002) (252)
Antidiabetic effects of IGFBP2, a leptin-regulated gene. (2010) (250)
A novel highly-penetrant form of obesity due to microdeletions on chromosome 16p11.2 (2009) (239)
Minireview: human obesity-lessons from monogenic disorders. (2003) (236)
Prevalence of Melanocortin-4 Receptor Deficiency in Europeans and Their Age-Dependent Penetrance in Multigenerational Pedigrees (2008) (235)
Proopiomelanocortin and energy balance: insights from human and murine genetics. (2004) (231)
Loss of Function of the Melanocortin 2 Receptor Accessory Protein 2 Is Associated with Mammalian Obesity (2013) (227)
A POMC variant implicates beta-melanocyte-stimulating hormone in the control of human energy balance. (2006) (222)
Mutations in the human melanocortin-4 receptor gene associated with severe familial obesity disrupts receptor function through multiple molecular mechanisms. (2003) (219)
Oral glutamine increases circulating glucagon-like peptide 1, glucagon, and insulin concentrations in lean, obese, and type 2 diabetic subjects. (2009) (218)
GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans (2019) (214)
Heterozygosity for a POMC-Null Mutation and Increased Obesity Risk in Humans (2006) (208)
Hyperphagia and early-onset obesity due to a novel homozygous missense mutation in prohormone convertase 1/3. (2007) (202)
20 years of leptin: human disorders of leptin action. (2014) (197)
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure underpinning obesity (2017) (193)
Human Obesity: A Heritable Neurobehavioral Disorder That Is Highly Sensitive to Environmental Conditions (2008) (188)
Genetic approaches to understanding human obesity. (2011) (187)
Food reward system: current perspectives and future research needs (2015) (180)
MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency (2018) (179)
Leptin predicts a worsening of the features of the metabolic syndrome independently of obesity. (2005) (168)
Evaluation of a melanocortin-4 receptor (MC4R) agonist (Setmelanotide) in MC4R deficiency (2017) (161)
KSR2 Mutations Are Associated with Obesity, Insulin Resistance, and Impaired Cellular Fuel Oxidation (2013) (158)
Obesity associated with increased brain age from midlife (2016) (156)
Rapid-Onset Obesity With Hypothalamic Dysfunction, Hypoventilation, and Autonomic Dysregulation Presenting in Childhood (2007) (156)
Human Gain-of-Function MC4R Variants Show Signaling Bias and Protect against Obesity (2019) (147)
The V103I polymorphism of the MC4R gene and obesity: population based studies and meta-analysis of 29 563 individuals (2007) (145)
Human SH2B1 mutations are associated with maladaptive behaviors and obesity. (2012) (141)
Obesity due to melanocortin 4 receptor (MC4R) deficiency is associated with increased linear growth and final height, fasting hyperinsulinemia, and incompletely suppressed growth hormone secretion. (2011) (137)
Melanocortin-4 receptor signaling is required for weight loss after gastric bypass surgery. (2012) (134)
Response to Letter: "Pediatric Obesity-Assessment, Treatment, and Prevention: An Endocrine Society Clinical Practice Guideline". (2017) (134)
Corrigendum: TCTEX1D2 mutations underlie Jeune asphyxiating thoracic dystrophy with impaired retrograde intraflagellar transport (2016) (131)
Rare variants in single-minded 1 (SIM1) are associated with severe obesity. (2013) (130)
WNT10B mutations in human obesity (2006) (129)
Recent advances in the genetics of severe childhood obesity (2000) (128)
A Quantitative Trait Locus on Chromosome 18q for Physical Activity and Dietary Intake in Hispanic Children (2006) (126)
Monogenic human obesity syndromes. (2004) (122)
The role of melanocortin signalling in the control of body weight: evidence from human and murine genetic models. (2000) (119)
Genetic factors in human obesity (2007) (119)
Genetics of obesity (2006) (119)
Novel FGF8 mutations associated with recessive holoprosencephaly, craniofacial defects, and hypothalamo-pituitary dysfunction. (2011) (117)
Amyotrophic lateral sclerosis and frontotemporal dementia: distinct and overlapping changes in eating behaviour and metabolism (2016) (113)
Genetic and hereditary aspects of childhood obesity. (2005) (113)
Prevalence of Loss-of-Function FTO Mutations in Lean and Obese Individuals (2009) (110)
Palmitic Acid Hydroxystearic Acids Activate GPR40, Which Is Involved in Their Beneficial Effects on Glucose Homeostasis. (2018) (109)
Food addiction: is there a baby in the bathwater? (2012) (107)
High protein intake stimulates postprandial GLP1 and PYY release (2013) (106)
Leptin and the onset of puberty: insights from rodent and human genetics. (2002) (105)
Resistance to thyroid hormone is associated with raised energy expenditure, muscle mitochondrial uncoupling, and hyperphagia. (2010) (101)
CNS Leptin Action Modulates Immune Response and Survival in Sepsis (2010) (99)
Efficacy and safety of setmelanotide, an MC4R agonist, in individuals with severe obesity due to LEPR or POMC deficiency: single-arm, open-label, multicentre, phase 3 trials. (2020) (98)
Increased body mass index is associated with specific regional alterations in brain structure (2016) (97)
New advances in the genetics of early onset obesity (2005) (95)
Human obesity as a heritable disorder of the central control of energy balance (2008) (94)
Sequential alterations in haemorheology, endothelial dysfunction, platelet activation and thrombogenesis in relation to prognosis following acute stroke: The West Birmingham Stroke Project (2002) (92)
Leptin regulates peripheral lipid metabolism primarily through central effects on food intake. (2008) (87)
Functional characterization of human NTRK2 mutations identified in patients with severe early-onset obesity (2007) (86)
Neural and Behavioral Effects of a Novel Mu Opioid Receptor Antagonist in Binge-Eating Obese People (2013) (85)
Functional characterization and structural modeling of obesity associated mutations in the melanocortin 4 receptor. (2009) (82)
Assessment of Eating Behavior Disturbance and Associated Neural Networks in Frontotemporal Dementia. (2016) (76)
Distinct Modulatory Effects of Satiety and Sibutramine on Brain Responses to Food Images in Humans: A Double Dissociation across Hypothalamus, Amygdala, and Ventral Striatum (2010) (73)
Contribution of variants in the small heterodimer partner gene to birthweight, adiposity, and insulin levels: mutational analysis and association studies in multiple populations. (2003) (71)
Genetic architecture of human thinness compared to severe obesity (2019) (70)
Binge eating as a phenotype of melanocortin 4 receptor gene mutations. (2003) (69)
Uncoupling protein 3 genetic variants in human obesity: the c-55t promoter polymorphism is negatively correlated with body mass index in a UK Caucasian population (2001) (69)
Ambulatory blood pressure monitoring in acute stroke. The West Birmingham Stroke Project. (1997) (68)
Insulin resistance, high prevalence of diabetes, and cardiovascular risk in immigrant Asians (1995) (66)
A Transcriptomic Signature of the Hypothalamic Response to Fasting and BDNF Deficiency in Prader-Willi Syndrome (2018) (66)
Prevalence and functionality of paucimorphic and private MC4R mutations in a large, unselected European British population, scanned by meltMADGE (2007) (65)
Human Semaphorin 3 Variants Link Melanocortin Circuit Development and Energy Balance (2019) (65)
Prolonged successful therapy for hyperinsulinaemic hypoglycaemia after gastric bypass: the pathophysiological role of GLP1 and its response to a somatostatin analogue. (2012) (65)
Mutation in human selenocysteine transfer RNA selectively disrupts selenoprotein synthesis. (2016) (64)
A Homozygous Mutation in the TUB Gene Associated with Retinal Dystrophy and Obesity (2013) (64)
Leptin Substitution Results in the Induction of Menstrual Cycles in an Adolescent with Leptin Deficiency and Hypogonadotropic Hypogonadism (2012) (63)
CNV Analysis in Tourette Syndrome Implicates Large Genomic Rearrangements in COL8A1 and NRXN1 (2013) (63)
Monogenic human obesity syndromes. (2006) (63)
Melanin-concentrating hormone receptor mutations and human obesity: functional analysis. (2004) (62)
Homozygosity for a novel missense mutation in the leptin receptor gene (P316T) in two Egyptian cousins with severe early onset obesity. (2011) (61)
Severe Early-Onset Obesity Due to Bioinactive Leptin Caused by a p.N103K Mutation in the Leptin Gene (2015) (61)
The CART gene and human obesity: mutational analysis and population genetics. (2000) (58)
Severe obesity and diabetes insipidus in a patient with PCSK1 deficiency☆ (2013) (55)
Genetic, molecular and physiological insights into human obesity (2011) (55)
Leptin therapy in a congenital leptin-deficient patient leads to acute and long-term changes in homeostatic, reward, and food-related brain areas. (2011) (55)
Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits (2020) (55)
Safety, immunogenicity, and reactogenicity of BNT162b2 and mRNA-1273 COVID-19 vaccines given as fourth-dose boosters following two doses of ChAdOx1 nCoV-19 or BNT162b2 and a third dose of BNT162b2 (COV-BOOST): a multicentre, blinded, phase 2, randomised trial (2022) (55)
ob gene mutations and human obesity (1998) (54)
TPIT mutations are associated with early-onset, but not late-onset isolated ACTH deficiency. (2004) (52)
Monogenic human obesity. (2008) (51)
Does physical activity energy expenditure explain the between-individual variation in plasma leptin concentrations after adjusting for differences in body composition? (2003) (50)
Monogenic Human Obesity (2008) (50)
Mutations in the amino-terminal region of proopiomelanocortin (POMC) in patients with early-onset obesity impair POMC sorting to the regulated secretory pathway. (2008) (50)
Studies of the peptide YY and neuropeptide Y2 receptor genes in relation to human obesity and obesity-related traits. (2004) (47)
Lipid Metabolism and Survival Across the Frontotemporal Dementia-Amyotrophic Lateral Sclerosis Spectrum: Relationships to Eating Behavior and Cognition. (2017) (46)
Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (2019) (45)
Energy expenditure in frontotemporal dementia: a behavioural and imaging study (2017) (44)
Rare Variant Analysis of Human and Rodent Obesity Genes in Individuals with Severe Childhood Obesity (2017) (43)
A Metabolomic Signature of Acute Caloric Restriction (2017) (43)
Studies of the SIM1 gene in relation to human obesity and obesity-related traits (2007) (43)
Molecular Genetic Analysis of Normosmic Hypogonadotropic Hypogonadism in a Turkish Population: Identification and Detailed Functional Characterization of a Novel Mutation in the Gonadotropin-Releasing Hormone Receptor Gene (2007) (42)
Sequence variants in the melatonin-related receptor gene (GPR50) associate with circulating triglyceride and HDL levels Published, JLR Papers in Press, January 25, 2006. (2006) (41)
Functional characterization of naturally occurring pathogenic mutations in the human leptin receptor. (2008) (40)
Divergent effects of central melanocortin signalling on fat and sucrose preference in humans (2016) (40)
GDF 15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans (2019) (38)
Melanocortin receptors weigh in (2004) (38)
Loss of function mutations in the melanocortin 4 receptor in a UK birth cohort (2021) (37)
Dopamine Modulates the Neural Representation of Subjective Value of Food in Hungry Subjects (2014) (36)
Rapid Improvement of Hepatic Steatosis after Initiation of Leptin Substitution in a Leptin-Deficient Girl (2013) (36)
Genetic variation in the corticotrophin-releasing factor receptors: identification of single-nucleotide polymorphisms and association studies with obesity in UK Caucasians (2004) (36)
Insights from the Genetics of Severe Childhood Obesity (2007) (35)
Defining the neural basis of appetite and obesity: from genes to behaviour. (2014) (33)
Food images engage subliminal motivation to seek food (2011) (31)
Genetic Variance in the Spinocerebellar Ataxia Type 2 (ATXN2) Gene in Children with Severe Early Onset Obesity (2009) (31)
Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis (2019) (31)
Ethnic differences in infant-rearing practices and their possible relationship to the incidence of sudden infant death syndrome (SIDS). (1993) (30)
The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW (2017) (30)
SnapShot: The Hormonal Control of Food Intake (2008) (29)
Functional Characterization of Obesity-Associated Variants Involving the α and β Isoforms of Human SH2B1 (2014) (28)
The severely obese patient—a genetic work-up (2006) (27)
Oxytocin administration suppresses hypothalamic activation in response to visual food cues (2017) (26)
Long-Term Stabilization Effects of Leptin on Brain Functions in a Leptin-Deficient Patient (2013) (26)
Association of polymorphisms in GPR10, the gene encoding the prolactin-releasing peptide receptor with blood pressure, but not obesity, in a U.K. Caucasian population. (2003) (25)
Failure of sucrose replacement with the non-nutritive sweetener erythritol to alter GLP-1 or PYY release or test meal size in lean or obese people (2016) (25)
Genetic, molecular and physiological mechanisms involved in human obesity: Society for Endocrinology Medal Lecture 2012 (2012) (25)
Is leptin an important physiological regulator of CRP? (2007) (24)
Human MC4R variants affect endocytosis, trafficking and dimerization revealing multiple cellular mechanisms involved in weight regulation (2021) (23)
Abnormal haemorheology, endothelial function and thrombogenesis in relation to hypertension in acute (ictus < 12 h) stroke patients: the West Birmingham Stroke Project (2001) (23)
Exome Sequencing Identifies Genes and Gene Sets Contributing to Severe Childhood Obesity, Linking PHIP Variants to Repressed POMC Transcription (2020) (22)
ProxECAT: Proxy External Controls Association Test. A new case-control gene region association test using allele frequencies from public controls (2018) (22)
Low-frequency variation in TP53 has large effects on head circumference and intracranial volume (2018) (22)
Hypothalamic Reproductive Endocrine Pulse Generator Activity Independent of Neurokinin B and Dynorphin Signaling. (2019) (21)
A New Drug Target for Type 2 Diabetes (2017) (21)
Catheter-induced left internal mammary artery bypass graft dissection. (1985) (21)
Obesity-Associated Melanocortin-4 Receptor Mutations Are Associated With Changes in the Brain Response to Food Cues (2014) (21)
A Novel Thyrotropin-Releasing Hormone Receptor Missense Mutation (P81R) in Central Congenital Hypothyroidism (2016) (20)
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (2017) (20)
Genetic aspects of severe childhood obesity. (2006) (20)
The Sleep/Wake Cycle is Directly Modulated by Changes in Energy Balance. (2016) (19)
Human BDNF/TrkB variants impair hippocampal synaptogenesis and associate with neurobehavioural abnormalities (2020) (18)
Mutational analysis of the serotonin receptor 5HT2c in severe early-onset human obesity. (2004) (17)
Bed sharing and smoking in the sudden infant death syndrome (1994) (16)
The energy balance model of obesity: beyond calories in, calories out. (2022) (16)
Quantitative mass spectrometry for human melanocortin peptides in vitro and in vivo suggests prominent roles for β-MSH and desacetyl α-MSH in energy homeostasis (2018) (16)
Human Obesity — Lessons from Monogenic Disorders (2003) (16)
Ethnic differences in infant care practices and in the incidence of sudden infant death syndrome in Birmingham. (1994) (16)
Obesity-Associated GNAS Mutations and the Melanocortin Pathway. (2021) (14)
Neural deletion of Sh2b1 results in brain growth retardation and reactive aggression (2017) (14)
Molecular characterization of an interstitial deletion of 1p31.3 in a patient with obesity and psychiatric illness and a review of the literature (2011) (14)
Leptin-Mediated Changes in the Human Metabolome (2020) (14)
Ethnic differences in sleeping position and in risk of cot death (1991) (13)
Potential role of gender specific effect of leptin receptor deficiency in an extended consanguineous family with severe early-onset obesity. (2018) (13)
Triple H syndrome: a novel autoimmune endocrinopathy characterized by dysfunction of the hippocampus, hair follicle, and hypothalamic-pituitary adrenal axis. (2000) (13)
Studies of the neuromedin U-2 receptor gene in human obesity: evidence for the existence of two ancestral forms of the receptor. (2004) (13)
Melanocortin receptors as targets in the treatment of obesity. (2007) (12)
OBEDIS Core Variables Project: European Expert Guidelines on a Minimal Core Set of Variables to Include in Randomized, Controlled Clinical Trials of Obesity Interventions (2020) (12)
Trappc9 deficiency causes parent-of-origin dependent microcephaly and obesity (2020) (11)
Postprandial total ghrelin suppression is modulated by melanocortin signaling in humans. (2013) (11)
Studying Food Reward and Motivation in Humans (2014) (10)
Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (2018) (10)
Crucial Role of the SH2B1 PH Domain for the Control of Energy Balance (2019) (10)
Characterization of human variants in obesity-related SIM1 protein identifies a hot-spot for dimerization with the partner protein ARNT2. (2014) (10)
Disruption of the homeodomain transcription factor orthopedia homeobox (Otp) is associated with obesity and anxiety (2017) (10)
Neural networks associated with body composition in frontotemporal dementia (2019) (10)
Functional characterisation of obesity-associated variants involving the alpha and beta isoforms of human SH 2 B 1 (2014) (10)
Monogenic Obesity Syndromes Provide Insights Into the Hypothalamic Regulation of Appetite and Associated Behaviors (2022) (9)
FTO and obesity: the missing link. (2011) (9)
A novel mutation in the leptin gene (W121X) in an Egyptian family (2014) (9)
Obesity genes-it's all about the parents! (2009) (9)
Investigating Halloysite Nanotubes as a Potential Platform for Oral Modified Delivery of Different BCS Class Drugs: Characterization, Optimization, and Evaluation of Drug Release Kinetics (2021) (8)
Evaluation of Prader-Willi Syndrome gene MAGEL2 in severe childhood-onset obesity. (2005) (8)
Quality by Design (QbD)-Based Numerical and Graphical Optimization Technique for the Development of Osmotic Pump Controlled-Release Metoclopramide HCl Tablets (2020) (8)
Genetics of Obesity Syndromes (2008) (8)
Treating obesity: does antagonism of NPY fit the bill? (2006) (7)
Genetic strategies to understand physiological pathways regulating body weight (2014) (7)
Natural History of Obesity Due to POMC, PCSK1, and LEPR Deficiency and the Impact of Setmelanotide (2022) (7)
Role of melanocortin signalling in the preference for dietary macronutrients in human beings (2015) (7)
The Therapeutic Value of Somatostatin and Its Analogues (1999) (7)
Two novel missense mutations in GPR54 in a subject with hypogonadotropic hypogonadism (2005) (6)
A comparative study of risk factors for acute myocardial infarction amongst men of Indo-origin in Trinidad and the UK. (1994) (5)
Title CNV Analysis in Tourette Syndrome Implicates Large GenomicRearrangements in COL 8 A 1 and NRXN 1 (2013) (5)
Erratum: Antidiabetic Effects of IGFBP2, a Leptin-Regulated Gene (DOI:10.1016/j.cmet.2009.11.007) (2010) (5)
Screening the human prepro-orexin gene in a single-centre narcolepsy cohort. (2007) (5)
A comparative study of risk factors for acute myocardial infarction amongst men of Indo-origin in Trinidad and the UK. (1994) (5)
Increased Soluble Adhesion Molecule P-Selectin, Von Willebrand Factor and Fibrinogen in Acute Stroke: Evidence for Early Endothelial and Haemorheological Dysfunction (1996) (5)
EJE Prize 2012: Obesity: from genes to behaviour. (2014) (5)
Monogenic human obesity syndromes. (2021) (5)
A Melanocortin-4 Receptor Agonist Induces Skin and Hair Pigmentation in Patients with Monogenic Mutations in the Leptin-Melanocortin Pathway (2021) (5)
Pharmacy Students Attitude and Stigmatization of People withSchizophrenia in Pakistan (2013) (5)
Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (2018) (4)
Murine neuronatin deficiency is associated with a hypervariable food intake and bimodal obesity (2021) (4)
Hypothalamic atrophy is related to body mass index and age at onset in amyotrophic lateral sclerosis (2017) (4)
Predicting novel candidate human obesity genes and their site of action by systematic functional screening in Drosophila (2021) (4)
Central obesity is selectively associated with cerebral gray matter atrophy in 15,634 subjects in the UK Biobank (2022) (4)
Genetic Obesity Syndromes (2019) (3)
MicroRNA-7 regulates melanocortin circuits involved in mammalian energy homeostasis (2022) (3)
Cardiovascular Disease? Influence of Leptin on Arterial Distensibility: A Novel Link Between Obesity and (2008) (3)
Iatrogenic chest pain: a case of 5-fluorouracil cardiotoxicity. (1996) (3)
Neural correlates of fat preference in frontotemporal dementia: translating insights from the obesity literature (2021) (3)
Melanocortin receptors and energy homeostasis (2005) (3)
Obesity due to melanocortin 4 receptor (MC4R) deficiency is associated with delayed gastric emptying (2021) (3)
Obesity: from genes to behaviour (2014) (3)
Blood pressure changes in acute stroke — The West Birmingham stroke project (1996) (3)
Genes and Obesity (2007) (3)
Reply to Unreliability of genotyping arrays for detecting very rare variants in human genetic studies: Example from a recent study of MC4R (2021) (2)
ESTIMATION OF MICROBIAL CONTAMINATION IN VARIOUS ACTIVE PHARMACEUTICAL INGREDIENTS AND EXCIPIENTS (2014) (2)
Weight Regulation and Monogenic Obesity (2010) (2)
Risk Factors for Acute Myocardial Infarction Amongst Asians from England and Trinidad (1994) (2)
Rare Variant Analysis of Human and Rodent Obesity Genes in Individuals with Severe Childhood Obesity (2017) (2)
Erratum: Rare variants in single-minded 1 (SIM1) are associated with severe obesity (Journal of Clinical Investigation (2013) 123:7 (3042-3050) DOI: 10.1172/JCI68016) (2013) (2)
Genetic Syndromes Associated with Obesity (2010) (2)
Sudden infant death syndrome among Asians in Britain (1994) (2)
Risk Factors for Acute Myocardial Infarction Amongst Asians from England and Trinidad (1994) (2)
Wired for Obesity? (2014) (2)
Leptin and the Onset of Puberty (2003) (2)
Genetic Evaluation of Obese Patients (2008) (2)
Making a Diagnosis in Severe Complex Obesity (2014) (1)
Scientific Business Abstracts of the 113th Annual Meeting of the Association of Physicians of Great Britain and Ireland. (2019) (1)
Chapter 28 – Genetic Syndromes Associated with Obesity∗ (2016) (1)
Visualization of sympathetic neural innervation in human white adipose tissue (2021) (1)
Eating Behaviour and Metabolic Changes across the Spectrum of Motor Neuron Disease and Frontotemporal Dementia. (I12-5E) (2015) (1)
Effects of Setmelanotide in Patients With POMC, PCSK1, or LEPR Heterozygous Deficiency Obesity in a Phase 2 Study (2021) (1)
Microbial Exposure in Childhood and Subsequent Atopy: Pertussis Immunisation and Oral Antibiotics (1998) (1)
Adiposity in the first half of life. Abstracts of the 27th Annual Meeting of the German Society for Obesity Research. October 6-8, 2011. Bochum, Germany. (2011) (1)
Low-frequency variation in TP53 has large effects on head circumference and intracranial volume (2019) (1)
Leptin replacement improves central ventilation in a patient with congenital leptin deficiency: first report in childhood (2015) (1)
Human Melanocortin 4 Receptor Deficiency (2009) (1)
Human mutations are associated withmaladaptive behaviors and obesity. (2013) (1)
The impact of acute nutritional interventions on the plasma proteome. (2023) (1)
Prevalence and expressivity of loss of function mutations in the Melanocortin 4 Receptor (MC4R) in a UK birth cohort (2020) (1)
Candidate Genes for Obesity — How Might They Interact with Environment and Diet ? (2005) (1)
Drug utilization evaluation of Piperacillin/Tazobactam: A prospective and cross sectional investigation in tertiary care setup. (2019) (1)
THE FIRST REPORT OF LEPR MUTATION IN AN IRANIAN MORBID OBESE CHILD (2007) (1)
Elevated Chlamydia Pneumoniae Antibody Titres are Associated with Acute Stroke Syndromes: the West Birmingham Stroke Project (1996) (1)
Obesity Due to Steroid Receptor Coactivator-1 Deficiency Is Associated With Endocrine and Metabolic Abnormalities (2022) (1)
Society for Endocrinology Medal Lecture (2012) (1)
PHARMACY STUDENTS' PERCEPTION AND ATTITUDE TOWARDS THE SCOPE OF CLINICAL PHARMACOGNOSY COURSE IN PAKISTAN (2015) (1)
Mutations in the gene encoding the fibroblast growth factor 8 (FGF8) are associated with complex midline defects including recessive holoprosencephaly and hypothalamo-pituitary dysfunction (2011) (1)
Human BDNF/TrkB variants impair hippocampal synaptogenesis and associate with neurobehavioural abnormalities (2020) (0)
Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (2018) (0)
POMC and PC1 Mutations (2007) (0)
Lancet Diabetes & Endocrinology Commission on the Definition and Diagnosis of Clinical Obesity. (2023) (0)
ESCI Announcement (2012) (0)
A Transcriptomic Signatur e of the Hypothalamic Response to Fasting and BDNF Deficiency in Prader-Willi Syndrome Graphical (2018) (0)
and cardiovascular risk in immigrant Asians Insulin resistance, high prevalence of diabetes, (2017) (0)
Modulation of the sleep–wake cycle by changes in energy balance (2016) (0)
Universitet Low-frequency variation in TP 53 has large effects on head circumference and intracranial (2019) (0)
Erratum: Human SH2B1 mutations are associated with maladaptive behaviors and obesity (Journal of Clinical Investigation (2013) 123:1 (526) DOI: 10.1172/JCI68022) (2013) (0)
Oxytocin administration suppresses hypothalamic activation in response to visual food cues (2017) (0)
Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (2018) (0)
225 IF LEPTIN IS THE CULPRIT, IS ESTROGEN THE ANTAGONIST IN OBESITY ASSOCIATED HYPERTENSION? (2012) (0)
Hypertension does not significantly alter abnormalities of haemorheology, endothelial dysfunction and thrombogenesis in acute stroke: the West birmingham stroke project. (1999) (0)
Human Leptin and Leptin Receptor Deficiency (2009) (0)
Genes and Common Diseases: Genetics of chronic disease: obesity (2007) (0)
Obesity (2020) (0)
Exome Sequencing Identifies Multiple Genes and Gene-Sets Contributing to Severe Childhood Obesity (2019) (0)
Biallelic mutations in P4HTM cause syndromic obesity. (2023) (0)
Edinburgh Research Explorer Human Semaphorin 3 Variants Link Melanocortin Circuit Development and Energy Balance (2019) (0)
Reply to Taubes, Friedman, and Torres-Carot et al. (2022) (0)
Dataset of Study Replacing Sucrose with Erythritol (2015) (0)
Chapter 2 Genetic Obesity Syndromes (2017) (0)
Genetic Evaluation of Patients with Syndromic and Nonsyndromic Obesity (2014) (0)
Genetics of Severe Childhood Obesity (2001) (0)
1 PERTUSSIS IMMUNIZATION AND ATOPIC DISEASE (1997) (0)
A rare human variant that disrupts GPR10 signalling causes weight gain in mice (2023) (0)
Advances in our understanding of the genetic causes of obesity (2011) (0)
OBESITY AS A DISEASE STATE OR ADIPOSITY (2006) (0)
A Practical Guide to the Clinical Assessment and Investigation of Obesity (2009) (0)
ANDRE‐MAYER AWARD AW0002 The leptin‐melanocortin pathway in human physiology: insights from genetics (2006) (0)
UK 10 K Consortium (2019) (0)
MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency (2018) (0)
Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (2019) (0)
Genetic Disorders Involving Leptin and the Leptin Receptor (2006) (0)
Elucidating the aetiology of Prader-Willi syndrome (2009) (0)
Human POMC processing in vitro and in vivo revealed by quantitative peptidomics (2018) (0)
Obesity-Associated GNAS Mutations and the Melanocortin Pathway. Reply. (2022) (0)
Impact of different organic acids on solubility enhancement of cefpodxime proxetil immediate release tablet and its stability studies. (2017) (0)
RF24 | PSUN91 Body Mass Index and Weight Reduction in Patients With SH2B1 Genetic Variant Obesity After One Year of Setmelanotide (2022) (0)
Melanocortin-4-receptor gene variants: hotspot or identical by descent? (2009) (0)
STABILITY STUDY OF ANTIBIOTIC ( CEFOTAXIME ) IN PERITONEAL DIALYSIS SOLUTION WITH VALIDATION OF ANALYZING METHOD (2013) (0)
Effect of starch, cellulose and povidone based superdisintegrants in a QbD-based approach for the development and optimization of Nitazoxanide orodispersible tablets: Physicochemical characterization, compaction behavior and in-silico PBPK modeling of its active metabolite Tizoxanide (2022) (0)
The clinical and molecular spectrum associated with obesity-associated GNAS1 mutations (2017) (0)
Eating behaviour and metabolism in amyotrophic lateral sclerosis and frontotemporal dementia: providing insights for neurodegeneration (2016) (0)
Biological bases of eating behavior disturbance in frontotemporal dementia (2016) (0)
013 Lipid metabolism and body composition in frontotemporal dementia-amyotrophic lateral sclerosis spectrum: effect on survival and disease progression (2018) (0)
Growth retardation and severe constipation due to the first human, dominant negative thyroid hormone receptor [alpha] mutation (2012) (0)
Elucidating the aetiology of Prader-Willi syndrome: deletion of the HBII-85 class of snoRNA is associated with hyperphagia, obesity and hypogonadism (2009) (0)
HISTORICAL NEWS AND VIEWS: Melanocortin receptors weigh in (2004) (0)
Design of a phase 2, double-Blind, placebo-controlled trial of setmelanotide in patients with genetic variants in the melanocortin-4 receptor pathway (2022) (0)
Tackling obesity: lessons from genetics (2012) (0)
Title Page / Table of Contents (2010) (0)
Molecular defects in leptin and their implications for pregnancy and fetal growth (2001) (0)
Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis (2019) (0)
Skeletal changes in pre-pubertal children with loss of function mutations in the melanocortin-4 receptor (2015) (0)
ODP605 Body Mass Index and Weight Reductions in Patients With SRC1 Genetic Variant Obesity After 1 Year of Setmelanotide (2022) (0)
Genetic strategies to understand physiological pathways regulating body weight (2014) (0)
Title : Six new loci associated with body mass index highlight a neuronal influence on body weight regulation (0)
Glycated haemoglobin association with severity of thrombus burden in non-diabetic versus diabetic patients with ST-elevation myocardial infarction. (2021) (0)
Acute energy balance alteration modifies sleep organization in healthy men (2017) (0)
Resistance to thyroid hormone alpha: molecular, biochemical and physiological approach to diagnosis and therapy (2022) (0)
Melanocortin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database (2019) (0)
OR10-1 Body Mass Index and Weight Reductions in Patients With Obesity Due to Heterozygous Variants in POMC, PCSK1, and LEPR After 1 Year of Setmelanotide (2022) (0)
Towards a Greater Understanding of the Pathophysiology of Obesity: Hypothalamic Obesity as a Model of Dysregulation of Appetite and Metabolic Homeostasis (2018) (0)
Modification and validation of liquid chromatographic method for the quantification of ciprofloxacin in human plasma and its application to a bioavailability study. (2021) (0)
RF24 | PSUN96 Setmelanotide in Patients With Heterozygous POMC, LEPR, SRC1, or SH2B1 Obesity: Design of EMANATE – A Placebo-Controlled Phase 3 Trial (2022) (0)
01-P010 Prader–Willi Syndrome and small nucleolar RNAs (2009) (0)
Subject Index Vol. 68, Suppl. 5, 2007 (2007) (0)
Quantification of appetite-regulating hormones in hypothalamic and simple obesity (2017) (0)
Editorial Board (2011) (0)
The effect of devaluation on food related motivation (2011) (0)
Proceedings of the annual meeting of the European Consortium of Lipodystrophies (ECLip) Cambridge, UK, 7-8 April 2022. (2022) (0)
Neuro-Hormonal Regulation of Immune and Metabolic Function (2005) (0)
Frequency and impact of slow flow / no flow in primary percutaneous coronary intervention. (2021) (0)
Severe Early-Onset Obesity Caused By Bioinactive Leptin due to a N103K Mutation (2015) (0)
A novel, missense, mutation (P81R) in the TRH receptor gene in congenital central hypothyroidism (2015) (0)
Putting a brake on hunger (2021) (0)
Melanocortin receptors in GtoPdb v.2021.3 (2021) (0)
Crohn’s Disease with Pyoderma Gangrenosum: A Sign of Severity of Disease (2013) (0)
Faculty Opinions recommendation of Neurogenesis in the hypothalamus of adult mice: potential role in energy balance. (2006) (0)
What have we learnt from the GOOS study (2015) (0)
Teaching vaginal examination. (1992) (0)
Faculty Opinions recommendation of NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates. (2005) (0)
Learning from experiments of nature (2004) (0)
THE IN VITRO-INDUCTIONOF TYPE II COLLAGEN-SPECIFICIMMUNE TOLERANCEIN BALB/C MICE (2013) (0)
Assessment of Obesity in Children (2021) (0)
Do cardiologists and non-cardiologists vary in their management of patients with atrial fibrillation? (1996) (0)

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