Salih J. Wakil
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Salih J. Wakilchemistry Degrees
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Chemistry
Salih J. Wakil's Degrees
- PhD Chemistry Stanford University
Why Is Salih J. Wakil Influential?
(Suggest an Edit or Addition)According to Wikipedia, Salih Jawad Wakil was an American biochemist. Wakil's laboratory discovered both Acetyl CoA Carboxylase and Fatty Acid Synthetase. Early life Wakil was born on August 16, 1927, in Karbala, Iraq to a shoemaker. After scoring in the top 5 on the national baccalaureate exam of Iraq, Wakil earned a scholarship to the American University of Beirut. Upon graduating in 1948 with a degree in chemistry, he emigrated to the United States to earn his PhD in biochemistry from the University of Washington. Upon completing his PhD, Wakil became a research associate at the Institute for Enzyme Research at the University of Wisconsin–Madison , where his research into fatty acid metabolism began.
Salih J. Wakil's Published Works
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Published Works
- Continuous Fatty Acid Oxidation and Reduced Fat Storage in Mice Lacking Acetyl-CoA Carboxylase 2 (2001) (875)
- Fatty acid synthesis and its regulation. (1983) (798)
- Fatty acid synthase, a proficient multifunctional enzyme. (1989) (777)
- THE MECHANISM OF FATTY ACID SYNTHESIS. (1960) (409)
- The subcellular localization of acetyl-CoA carboxylase 2. (2000) (398)
- Fatty acid metabolism: target for metabolic syndrome This work is supported by grants from the National Institute of Health (GM-63115), the Hefni Technical Training Foundation, and the Medallion Foundation. Published, JLR Papers in Press, December 1, 2008. (2009) (391)
- Acetyl-CoA carboxylase 2 mutant mice are protected against obesity and diabetes induced by high-fat/high-carbohydrate diets (2003) (379)
- Continuous fat oxidation in acetyl–CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity (2007) (317)
- A MALONIC ACID DERIVATIVE AS AN INTERMEDIATE IN FATTY ACID SYNTHESIS (1958) (266)
- Liver-specific deletion of acetyl-CoA carboxylase 1 reduces hepatic triglyceride accumulation without affecting glucose homeostasis. (2006) (262)
- Mutant mice lacking acetyl-CoA carboxylase 1 are embryonically lethal. (2005) (246)
- Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease (2009) (237)
- Studies on fatty acid oxidation. I. Enzymatic activation of fatty acids. (1953) (230)
- Evidence for the participation of biotin in the enzymic synthesis of fatty acids. (1958) (223)
- Fatty acid synthesis is essential in embryonic development: Fatty acid synthase null mutants and most of the heterozygotes die in utero (2003) (217)
- A small molecule that blocks fat synthesis by inhibiting the activation of SREBP. (2009) (209)
- Human fatty acid synthase: properties and molecular cloning. (1995) (204)
- Human acetyl-CoA carboxylase: characterization, molecular cloning, and evidence for two isoforms. (1995) (180)
- Structure and function of animal fatty acid synthase (2004) (176)
- Human Acetyl-CoA Carboxylase 2 (1997) (175)
- The molecular organization of lipids in the membrane of Escherichia coli: phase transitions. (1971) (161)
- Human fatty acid synthase: structure and substrate selectivity of the thioesterase domain. (2004) (159)
- Studies on the mechanism of fatty acid synthesis. V. Bicarbonate requirement for the synthesis of long-chain fatty acids. (1958) (147)
- ON THE MECHANISM OF FATTY ACID SYNTHESIS1 (1959) (144)
- Glucose and fat metabolism in adipose tissue of acetyl-CoA carboxylase 2 knockout mice. (2005) (142)
- The complete amino acid sequence of the acyl carrier protein of Escherichia coli. (1968) (136)
- Studies on the mechanism of fatty acid synthesis. II. Cofactor requirements of the soluble pigeon liver system. (1957) (132)
- Studies on the mechanism of fatty acid synthesis. XII. Acetyl coenzyme A carboxylase. (1962) (131)
- Control of Fatty Acid Metabolism I. Induction of the Enzymes of Fatty Acid Oxidation in Escherichia coli (1969) (130)
- A requirement for lipids by the microsomal stearyl coenzyme A desaturase. (1969) (127)
- The pathways of synthesis of fatty acids by mitochondria. (1962) (115)
- Studies on the mechanism of fatty acid synthesis. 9. The conversion of malonyl coenzyme A to long chain fatty acids. (1961) (114)
- Studies on the mechanism of fatty acid synthesis. XIX. Preparation and general properties of palmityl thioesterase. (1968) (111)
- SYNTHESIS OF FATTY ACIDS IN ANIMAL TISSUES. I. INCORPORATION OF C14-ACETYL COENZYME A INTO A VARIETY OF LONG CHAIN FATTY ACIDS BY SUBCELLULAR PARTICLES. (1963) (110)
- Animal fatty acid synthetase. A novel arrangement of the beta-ketoacyl synthetase sites comprising domains of the two subunits. (1981) (105)
- Cloning of the yeast FAS3 gene and primary structure of yeast acetyl-CoA carboxylase. (1992) (99)
- Studies on the mechanism of fatty acid synthesis. I. Preparation and purification of an enzymes system for reconstruction of fatty acid synthesis. (1957) (96)
- Studies on the mechanism of fatty acid synthesis. 18. Preparation and general properties of the enoyl acyl carrier protein reductases from Escherichia coli. (1968) (95)
- Primary structure of the multifunctional alpha subunit protein of yeast fatty acid synthase derived from FAS2 gene sequence. (1988) (93)
- Experimental verification of conformational variation of human fatty acid synthase as predicted by normal mode analysis. (2004) (92)
- Requirement for reduced diphosphopyridine nucleotide-cytochrome b5 reductase in stearly coenzyme A desaturation. (1970) (90)
- Studies on the mechanism of fatty acid synthesis VIII. The participation of protein-bound biotin in the biosynthesis of fatty acids (1960) (87)
- Sterol regulation of human fatty acid synthase promoter I requires nuclear factor-Y- and Sp-1-binding sites. (2000) (86)
- Human fatty acid synthase: Role of interdomain in the formation of catalytically active synthase dimer (2001) (85)
- Acute hormonal control of acetyl-CoA carboxylase. The roles of insulin, glucagon, and epinephrine. (1990) (85)
- Presence of two polypeptide chains comprising fatty acid synthetase. (1975) (84)
- Control of fatty acid composition in phospholipids of Escherichia coli: response to fatty acid supplements in a fatty acid auxotroph. (1969) (84)
- A requirement for phospholipids by the microsomal reduced diphosphopyridine nucleotide-cytochrome c reductase. (1967) (84)
- SYNTHESIS OF FATTY ACIDS IN ANIMAL TISSUES. II. THE OCCURRENCE AND BIOSYNTHESIS OF CIS-VACCENIC ACID. (1964) (78)
- ON THE BIOSYNTHESIS OF DIENOIC FATTY ACID BY ANIMAL TISSUES. (1963) (77)
- Studies on the fatty acid oxidizing system of animal tissues. VI. beta-Hydroxyacyl coenzyme A dehydrogenase. (1954) (74)
- Studies on the mechanism of fatty acid synthesis. XXVI. Purification and properties of malonyl-coenzyme A--acyl carrier protein transacylase of Escherichia coli. (1971) (74)
- Acetyl-CoA Carboxylase 2−/− Mutant Mice are Protected against Fatty Liver under High-fat, High-carbohydrate Dietary and de Novo Lipogenic Conditions* (2012) (74)
- Complementation of mutations and nucleotide sequence of FAS1 gene encoding beta subunit of yeast fatty acid synthase. (1987) (72)
- Domain movements in human fatty acid synthase by quantized elastic deformational model (2002) (69)
- Activation of acetyl-CoA carboxylase. Purification and properties of a Mn2+-dependent phosphatase. (1985) (68)
- Regulation of acetyl-coenzyme A carboxylase. I. Purification and properties of two forms of acetyl-coenzyme A carboxylase from rat liver. (1988) (66)
- The architecture of the animal fatty acid synthetase complex. IV. Mapping of active centers and model for the mechanism of action. (1983) (64)
- Regulation by temperature of the chain length of fatty acids in yeast. (1979) (60)
- Studies on the mechanism of fatty acid synthesis. XV. Preparation and general properties of beta-ketoacyl acyl carrier protein reductase from Escherichia coli. (1966) (59)
- In vitro synthesis of lignoceric and nervonic acids in mammalian liver and brain. (1970) (57)
- A Saccharomyces cerevisiae mutant strain defective in acetyl-CoA carboxylase arrests at the G2/M phase of the cell cycle (2003) (57)
- Animal fatty acid synthase: functional mapping and cloning and expression of the domain I constituent activities. (1997) (57)
- Human acetyl-CoA carboxylase 1 gene: Presence of three promoters and heterogeneity at the 5′-untranslated mRNA region (2003) (56)
- Studies on the mechanism of fatty acid synthesis. XVII. Preparation and general properties of acetyl coenzyme A and malonyl coenzyme A-acyl carrier protein transacylases. (1966) (56)
- Studies on the mechanism of fatty acid synthesis. XI. The product of the reaction and the role of sulfhydryl groups in the synthesis of fatty acids. (1962) (55)
- Studies on the yeast fatty acid synthetase. Subunit composition and structural organization of a large multifunctional enzyme complex. (1978) (54)
- Physicochemical studies of the rat liver and adipose fatty acid synthetases. (1979) (54)
- aP2-Cre-mediated inactivation of acetyl-CoA carboxylase 1 causes growth retardation and reduced lipid accumulation in adipose tissues (2009) (49)
- Site-directed mutagenesis studies on the recombinant thioesterase domain of chicken fatty acid synthase expressed in Escherichia coli. (1991) (48)
- On the question of half- or full-site reactivity of animal fatty acid synthetase. (1984) (48)
- Regulation of acetyl-coenzyme A carboxylase. II. Effect of fasting and refeeding on the activity, phosphate content, and aggregation state of the enzyme. (1988) (48)
- Purification and properties of a palmityl thioesterase II from Escherichia coli. (1970) (46)
- Studies on the mechanism of fatty acid synthesis VI. Spectrophotometric assay and stoichiometry of fatty acid synthesis (1959) (45)
- REQUIREMENT FOR BICARBONATE IN FATTY ACID SYNTHESIS1 (1958) (45)
- Identification of thyroid hormone response elements in the human fatty acid synthase promoter. (1998) (44)
- Studies on the fatty acid oxidizing system of animal tissues. V. Unsaturated fatty acyl coenzyme A hydrase. (1954) (44)
- [7a] Fatty acid synthase from chicken liver (1975) (44)
- Reduced Heart Size and Increased Myocardial Fuel Substrate Oxidation in ACC2 Mutant Mice (2007) (44)
- Characterization of recombinant thioesterase and acyl carrier protein domains of chicken fatty acid synthase expressed in Escherichia coli. (1989) (43)
- Positional specificities of acyl coenzyme A: glycerophosphate and acyl coenzyme A: monoacylglycerophosphate acyltransferases in Escherichia coli. (1973) (43)
- Quaternary structure of human fatty acid synthase by electron cryomicroscopy (2001) (41)
- Human Fatty-acid Synthase Gene (1996) (41)
- The architecture of the animal fatty acid synthetase. II. Separation of the core and thioesterase functions and determination of the N-C orientation of the subunit. (1983) (40)
- Roles of Ser101, Asp236, and His237 in catalysis of thioesterase II and of the C-terminal region of the enzyme in its interaction with fatty acid synthase. (1993) (39)
- Studies on the mechanism of fatty acid synthesis. X. Reduced triphosphopyridine nucleotide-acetoacetyl coenzyme A reductase. (1962) (38)
- Factors affecting the acyl selectivities of acyltransferases in Escherichia coli. (1976) (38)
- The architecture of the animal fatty acid synthetase. I. Proteolytic dissection and peptide mapping. (1983) (37)
- Studies on the mechanism of fatty acid synthesis. XVI. Preparation and general properties of acyl-malonyl acyl carrier protein-condensing enzyme from Escherichia coli. (1966) (37)
- Cloning and expression of the multifunctional human fatty acid synthase and its subdomains in Escherichia coli. (1996) (37)
- Studies on the mechanism of fatty acid synthesis. 13. The role of beta-hydroxy acids in the synthesis of palmitate and cis vaccenate by the Escherichia coli enzyme system. (1966) (37)
- Studies on the control of fatty acid metabolism. 3. Incorporation of fatty acids into phospholipids and regulation of fatty acid synthetase of Escherichia coli. (1971) (37)
- On the 4'-phosphopantetheine content of chicken and rat liver fatty acid synthetases. (1976) (36)
- Studies on the mechanism of fatty acid synthesis. XXI. The role of fructose 1,6-diphosphate in the stimulation of the fatty acid synthetase from pigeon liver. (1968) (36)
- Studies on the mechanism of action of acetyl coenzyme A carboxylase. I. Effect of isocitrate on the transcarboxylation step of acetyl coenzyme A carboxylase. (1963) (35)
- The preparation of tryptic, peptic, thermolysin, and cyanogen bromide peptides from the acyl carrier protein of Escherichia coli. (1968) (35)
- Studies on the control of fatty acid metabolism. II. The inhibition of fatty acid synthesis in Lactobacillus plantarum by exogenous fatty acid. (1970) (34)
- Yeast fatty acid synthase: structure to function relationship. (1985) (33)
- Isolation and chromosomal mapping of genomic clones encoding the human fatty acid synthase gene. (1994) (33)
- Studies on the mechanism of fatty acid synthesis. 23. The acyl binding sites of the pigeon liver fatty acid synthetase. (1970) (33)
- Studies on the fatty acid oxidizing system of animal tissues. IX. Stereospecificity of unsaturated acyl CoA hydrase. (1956) (32)
- The yeast fatty acid synthetase. Structure-function relationship and the role of the active cysteine-SH and pantetheine-SH. (1981) (32)
- Molecular organization of lipids in Escherichia coli membranes. II. Effect of phospholipids on succinic-ubiquinone reductase activity. (1972) (32)
- Crystal structure of FAS thioesterase domain with polyunsaturated fatty acyl adduct and inhibition by dihomo-γ-linolenic acid (2011) (31)
- The reconstruction of the fatty acid oxidizing system of animal tissues. (1953) (30)
- Further evidence for the multifunctional enzyme characteristic of the fatty acid synthetases of animal tissues. (1978) (30)
- d(−)β-hydroxybutyryl CoA dehydrogenase☆ (1955) (29)
- Small-angle neutron-scattering and electron microscope studies of the chicken liver fatty acid synthase. (1987) (29)
- Separation of dimethylaminoazobenzenethiohydantoin amino acids by high-performance liquid chromatography at low picomole concentrations. (1984) (28)
- Quantitative Determination of Coenzyme A by Sorbyl Coenzyme A Formation (1960) (27)
- Structure-function relationships of the yeast fatty acid synthase: negative-stain, cryo-electron microscopy, and image analysis studies of the end views of the structure. (1992) (27)
- A novel cDNA extension procedure. Isolation of chicken fatty acid synthase cDNA clones. (1989) (27)
- Synthesis and evaluation of diarylthiazole derivatives that inhibit activation of sterol regulatory element-binding proteins. (2011) (27)
- The isolation and characterization of fatty-acid synthetase mRNA from rat mammary gland. (1981) (27)
- The architecture of the animal fatty acid synthetase. III. Isolation and characterization of beta-ketoacyl reductase. (1983) (26)
- Fatty Acid Metabolism (1971) (26)
- Animal fatty acid synthetase. Identification of the residues comprising the novel arrangement of the beta-ketoacyl synthetase site and their role in its cold inactivation. (1982) (26)
- 2-MERCAPTOETHYLAMINE AND BETA-ALANINE AS COMPONENTS OF ACYL CARRIER PROTEIN. (1964) (25)
- Relation Between Protein Synthesis and Phospholipid Synthesis and Turnover in Escherichia coli (1972) (23)
- Stimulation of fatty acid biosynthesis by phosphorylated sugars. (1966) (22)
- Yeast fatty acid synthetase: structure-function relationship and nature of the beta-ketoacyl synthetase site. (1980) (21)
- Isolation and mapping of the beta-hydroxyacyl dehydratase activity of chicken liver fatty acid synthase. (1988) (21)
- The Origin of Some of the Carbon Atoms of the Side Chain of C14-Ergosterol1 (1953) (21)
- Hormonal regulation of hepatic fatty acid synthetase in chick embryo. Role of insulin. (1978) (21)
- Induction of microsomal stearyl coenzyme A desaturase in the newly hatched chicks. (1976) (20)
- Regulation of fatty acid synthetase in perinatal chicks. Identification of polysomes synthesizing fatty acid synthetase. (1977) (20)
- Fatty acid metabolism and ketone body formation. (1962) (20)
- Studies on the mechanism of fatty acid synthesis. XXII. Salt activation of the fatty acid-synthesizing enzymes of Escherichia coli. (1969) (20)
- Synthesis of Fatty Acids by Mitochondria (1960) (19)
- Assay for the terminal enzyme of the stearoyl coenzyme A desaturase system using chick embryo liver microsomes. (1977) (19)
- The isolation of the two subunits of yeast fatty acid synthetase. (1978) (19)
- Studies on the mechanism of action of acetyl coenzyme A carboxylase. II. On the mechanism of action of enzyme-bound biotin. (1963) (19)
- Studies on absorption and metabolism of ergosterol-C. (1953) (18)
- Studies on the mechanism of fatty acid synthesis. XXIV. The acetyl- and malonyltransacylase activities of pigeon liver fatty acid synthetase. (1970) (18)
- Chapter I – Fatty Acid Metabolism (1970) (18)
- Molecular cloning of fatty acid synthetase genes from Saccharomyces cerevisiae. (1983) (17)
- Human fatty acid synthase: assembling recombinant halves of the fatty acid synthase subunit protein reconstitutes enzyme activity. (1997) (16)
- Studies on the mechanism of fatty acid synthesis. XX. Preparation and general properties of beta-hydroxybutyryl acyl carrier protein dehydrase. (1968) (15)
- Enzymatic synthesis of fatty acids. (1962) (15)
- Goose fatty acid synthetase mRNA. (1980) (15)
- 1 Structure and Mechanism of Fatty Acid Synthetase (1983) (14)
- Intermediate- and long-chain beta-hydroxyacyl-ACP dehydrases from E. coli fatty acid synthetase. (1968) (14)
- Biosynthesis of fatty acids by soluble enzyme fractions. (1957) (14)
- Increased synthesis and accumulation of phospholipids during differentiation of 3T3-L1 cells into adipocytes. (1983) (14)
- Isolation and characterization of a novel acetyl-CoA carboxylase kinase from rat liver. (1994) (14)
- The reaction of chicken liver fatty acid synthetase with 5,5'-dithiobis(2-nitrobenzoic acid). (1982) (14)
- Amino-terminal blocking group and sequence of the animal fatty acid synthase. (1994) (13)
- Fatty acid synthase from chicken liver. (1975) (13)
- Turnover of Phospholipids in an Unsaturated Fatty Acid Auxotroph of Escherichia coli (1972) (13)
- Comparative mitochondrial oxidation of fatty acids. (1971) (13)
- Colchicine inhibition of insulin induction of stearoyl-CoA desaturase and fatty acid synthetase in cultured avian liver explants. (1984) (13)
- Effect of lipids on the reconstitution of D-lactate oxidase in Escherichia coli membrane vesicles. (1976) (12)
- Characterization of a genomic and cDNA clone coding for the thioesterase domain and 3' noncoding region of the chicken liver fatty acid synthase gene. (1988) (12)
- A rapid purification method for rat liver pyruvate carboxylase and amino acid sequence analyses of NH2-terminal and biotin peptide. (1988) (11)
- Lipid metabolism. (1962) (11)
- The arrangement and role of some of the amino acid residues in the beta-ketoacyl synthetase site of chicken liver fatty acid synthetase. (1983) (10)
- Studies on the mechanism of action of acetyl coenzyme A carboxylase. 3. Enzyme-bound 1'-N-carboxybiotin as the carboxylation intermediate. (1966) (10)
- Comparative studies on the kinetic parameters and product analyses of chicken and rat liver and yeast fatty acid synthetase. (1982) (10)
- The yeast fatty acid synthase. Pathway for transfer of the acetyl group from coenzyme A to the Cys-SH of the condensation site. (1990) (9)
- The Relationship between Structure and Function for and the Regulation of the Enzymes of Fatty Acid Synthesis a (1986) (9)
- Complete amino acid sequence of the thioesterase domain of chicken liver fatty acid synthase. (1988) (9)
- [12] Enoyl acyl carrier protein reductases from Escherichia Coli (1969) (9)
- On the mechanism of action of enzyme-bound biotin. (1962) (8)
- Studies on the mechanism of fatty acid synthesis. XIV. The prosthetic group of acyl carrier protein and the mode of its attachment to the protein. (1965) (8)
- Assembly of lipids and proteins in Escherichia coli membranes. (1974) (8)
- Complete amino acid sequence of chicken liver acyl carrier protein derived from the fatty acid synthase. (1989) (7)
- Studies on the mechanism of fatty acid synthesis. XXV. On the mechanism of beta-ketoacylacyl carrier protein reductase from Escherichia coli. (1971) (7)
- Mislocalization and inhibition of acetyl-CoA carboxylase 1 by a synthetic small molecule. (2012) (6)
- Chicken liver fatty acid synthetase: Proteolysis by subtilisin and isolation and properties of palmitoyl thioesterase (1982) (5)
- Interaction of the fluorescent analogue stearoyl-(1,N6)-etheno coenzyme A with chicken liver acetyl coenzyme A carboxylase. (1980) (5)
- Stearoyl-coenzyme a desaturase activity in the mammary gland and liver of lactating rats (1982) (5)
- David Ezra Green. (2004) (3)
- Fatty acid synthesis in aorta. Isolation of fatty acid synthetase from chicken aorta. (1977) (3)
- Radio-labeling of the PstI restriction fragments and improvement in the sequencing procedure. (1986) (3)
- The fatty acid synthetase-structure-function relationship and mechanism of palmitate synthesis. (1981) (3)
- Inactivation of yeast fatty acid synthetase by modifying the beta-ketoacyl reductase active lysine residue with pyridoxal 5'-phosphate. (1983) (2)
- Reply to Hoehn et al.: Phenotypic Discrepancies in Acetyl-CoA Carboxylase 2-deficient Mice (2012) (2)
- Reactions of hydroxylamine with acetoacetyl thioesters or ethyl acetoacetate. (1970) (2)
- The Response of Escherichia Coli to Fatty Acid Supplements and the Regulation of Membrane Lipid Synthesis (1971) (2)
- The development and application of a novel chromophoric substrate for investigation of the mechanism of yeast fatty acid synthase. (1985) (1)
- Isolation and Mapping of the @-Hydroxyacyl Dehydratase Activity of Chicken Liver Fatty Acid Synthase* (2001) (1)
- [78] Malonyl coenzyme A (1963) (1)
- D(-)beta-Hydroxybutyryl CoA dehydrogenase. (1955) (1)
- Pyruvate and fatty acid metabolism (1971) (1)
- [A thermosenitive mutant of Escherichia coli having membrane abnormalities]. (1969) (1)
- A micromethod for identification of hydroxy acids. (1968) (1)
- The role of lipids in the structure and function of E. coli membrane. (1972) (0)
- Mis-localization and inhibition of ACC1 by a synthetic small molecule. (2012) (0)
- Adipose‐specific knockout of acetyl‐CoA carboxylase 1 causes growth retardation and reduced de novo fatty acid synthesis in fat tissues (2008) (0)
- Electron microscope and small angle neutron scattering studies of chicken liver fatty acid synthase (1986) (0)
- Fatty Acid Synthetases of Eukaryotic Cells (1985) (0)
- Single Particle Reconstruction of Human Fatty Acid Synthase (2000) (0)
- Regulation of de novo lipid synthesis by small organic molecules, fatostatins (2011) (0)
- LIPID METABOLISMl.2 (1961) (0)
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